"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "WikiPathways" "Reactome Pathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 37C) / (126, 37C)" "Abundance Ratio: (127C, 37C) / (126, 37C)" "Abundance Ratio: (128N, 37C) / (126, 37C)" "Abundance Ratio: (128C, 37C) / (126, 37C)" "Abundance Ratio: (129N, 37C) / (126, 37C)" "Abundance Ratio: (129C, 37C) / (126, 37C)" "Abundance Ratio: (130N, 37C) / (126, 37C)" "Abundance Ratio: (130C, 37C) / (126, 37C)" "Abundance Ratio: (131, 37C) / (126, 37C)" "Abundances (Grouped): 126, 37C" "Abundances (Grouped): 127N, 37C" "Abundances (Grouped): 127C, 37C" "Abundances (Grouped): 128N, 37C" "Abundances (Grouped): 128C, 37C" "Abundances (Grouped): 129N, 37C" "Abundances (Grouped): 129C, 37C" "Abundances (Grouped): 130N, 37C" "Abundances (Grouped): 130C, 37C" "Abundances (Grouped): 131, 37C" "Abundances (Grouped) CV [%]: 126, 37C" "Abundances (Grouped) CV [%]: 127N, 37C" "Abundances (Grouped) CV [%]: 127C, 37C" "Abundances (Grouped) CV [%]: 128N, 37C" "Abundances (Grouped) CV [%]: 128C, 37C" "Abundances (Grouped) CV [%]: 129N, 37C" "Abundances (Grouped) CV [%]: 129C, 37C" "Abundances (Grouped) CV [%]: 130N, 37C" "Abundances (Grouped) CV [%]: 130C, 37C" "Abundances (Grouped) CV [%]: 131, 37C" "Abundance: F19: 126, Sample, 37C" "Abundance: F19: 127N, Sample, 37C" "Abundance: F19: 127C, Sample, 37C" "Abundance: F19: 128N, Sample, 37C" "Abundance: F19: 128C, Sample, 37C" "Abundance: F19: 129N, Sample, 37C" "Abundance: F19: 129C, Sample, 37C" "Abundance: F19: 130N, Sample, 37C" "Abundance: F19: 130C, Sample, 37C" "Abundance: F19: 131, Sample, 37C" "Abundances Count: F19: 126, Sample, 37C" "Abundances Count: F19: 127N, Sample, 37C" "Abundances Count: F19: 127C, Sample, 37C" "Abundances Count: F19: 128N, Sample, 37C" "Abundances Count: F19: 128C, Sample, 37C" "Abundances Count: F19: 129N, Sample, 37C" "Abundances Count: F19: 129C, Sample, 37C" "Abundances Count: F19: 130N, Sample, 37C" "Abundances Count: F19: 130C, Sample, 37C" "Abundances Count: F19: 131, Sample, 37C" "Found in Sample: [S61] F19: 126, Sample, 37C" "Found in Sample: [S62] F19: 127N, Sample, 37C" "Found in Sample: [S63] F19: 127C, Sample, 37C" "Found in Sample: [S64] F19: 128N, Sample, 37C" "Found in Sample: [S65] F19: 128C, Sample, 37C" "Found in Sample: [S66] F19: 129N, Sample, 37C" "Found in Sample: [S67] F19: 129C, Sample, 37C" "Found in Sample: [S68] F19: 130N, Sample, 37C" "Found in Sample: [S69] F19: 130C, Sample, 37C" "Found in Sample: [S70] F19: 131, Sample, 37C" "# Protein Groups" "Modifications" "-880435081762619547" "False" "High" "IsMasterProtein" "Q09666" "Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2" "0.000" "False" "709.356" "39" "118" "239" "118" "5890" "628.7" "6.15" "753.05" "118" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "79026" "ENSG00000124942" "AHNAK" "A1A586; hsa:79026; Q09666" "" "" "0" "0" "0.942" "0.955" "1.025" "0.986" "0.968" "1.052" "0.986" "0.904" "0.968" "13430.6" "12656.7" "12822.8" "13769.9" "13247.7" "12996.7" "14135.4" "13238.5" "12134.9" "13005.4" "" "" "" "" "" "" "" "" "" "" "13430.6" "10707.9" "8108.0" "10040.3" "10854.0" "10093.0" "10896.1" "11382.4" "9472.0" "11692.6" "96" "96" "96" "96" "96" "96" "96" "96" "96" "96" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "647.401" "45" "77" "273" "64" "1960" "226.4" "5.60" "976.95" "77" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "17" "11" "1.106" "1.001" "1.089" "1.126" "0.988" "1.109" "1.078" "0.971" "1.049" "15243.1" "16861.6" "15250.9" "16599.0" "17168.1" "15058.5" "16905.6" "16434.5" "14795.4" "15983.9" "" "" "" "" "" "" "" "" "" "" "15243.1" "14265.3" "9643.2" "12103.1" "14065.9" "11694.1" "13031.5" "14130.3" "11548.8" "14370.3" "81" "81" "81" "81" "81" "81" "81" "81" "81" "81" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "466.874" "20" "92" "149" "92" "4646" "532.1" "6.40" "494.81" "92" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Neutrophil degranulation; HCMV Early Events; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "24" "0" "1.006" "0.950" "1.027" "1.008" "0.963" "1.026" "1.024" "0.945" "1.006" "8255.7" "8308.2" "7843.3" "8478.2" "8325.5" "7949.4" "8468.1" "8454.9" "7800.1" "8301.8" "" "" "" "" "" "" "" "" "" "" "8255.7" "7028.9" "4959.4" "6181.8" "6821.1" "6173.3" "6527.6" "7269.5" "6088.5" "7463.8" "71" "71" "71" "71" "71" "71" "71" "71" "71" "71" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "447.265" "31" "64" "179" "64" "2511" "273.3" "6.44" "617.77" "64" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "18" "0" "0.963" "0.940" "0.992" "0.978" "0.956" "0.965" "0.976" "0.945" "0.976" "8726.1" "8403.1" "8204.5" "8654.8" "8536.8" "8341.4" "8421.9" "8516.1" "8242.8" "8520.0" "" "" "" "" "" "" "" "" "" "" "8726.1" "7109.2" "5187.7" "6310.6" "6994.3" "6477.8" "6491.9" "7322.2" "6434.0" "7660.0" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "434.440" "35" "72" "155" "64" "2541" "269.6" "6.07" "512.36" "72" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "18" "5" "1.008" "1.066" "1.030" "0.974" "1.045" "0.993" "0.999" "1.072" "1.024" "6352.5" "6406.0" "6769.3" "6543.9" "6186.3" "6641.4" "6306.6" "6344.4" "6812.4" "6505.7" "" "" "" "" "" "" "" "" "" "" "6352.5" "5419.6" "4280.3" "4771.5" "5068.5" "5157.6" "4861.4" "5454.9" "5317.5" "5849.0" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "386.125" "29" "62" "116" "56" "2647" "280.6" "6.06" "424.63" "62" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "14" "4" "1.003" "0.973" "0.967" "0.979" "0.971" "0.982" "0.985" "0.962" "0.995" "6503.7" "6521.9" "6326.8" "6291.0" "6366.7" "6314.6" "6385.5" "6406.5" "6258.6" "6472.4" "" "" "" "" "" "" "" "" "" "" "6503.7" "5517.7" "4000.5" "4587.0" "5216.2" "4903.8" "4922.2" "5508.3" "4885.3" "5819.1" "52" "52" "52" "52" "52" "52" "52" "52" "52" "52" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "378.381" "22" "83" "131" "83" "4128" "468.8" "7.12" "428.72" "83" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "13" "0" "1.035" "0.852" "1.002" "1.008" "0.879" "0.993" "0.995" "0.861" "0.971" "7910.3" "8184.3" "6737.3" "7923.7" "7976.5" "6956.0" "7855.0" "7868.4" "6808.0" "7677.7" "" "" "" "" "" "" "" "" "" "" "7910.3" "6924.1" "4260.0" "5777.5" "6535.2" "5401.9" "6055.0" "6765.3" "5314.0" "6902.6" "62" "62" "62" "62" "62" "62" "62" "62" "62" "62" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "355.642" "19" "84" "96" "83" "4684" "531.5" "5.96" "321.22" "84" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Envelope proteins and their potential roles in EDMD physiopathology" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "4" "0" "1.091" "1.177" "1.148" "1.117" "1.181" "1.169" "1.096" "1.187" "1.139" "3299.9" "3598.8" "3884.3" "3788.2" "3685.1" "3896.6" "3856.4" "3616.8" "3918.2" "3757.1" "" "" "" "" "" "" "" "" "" "" "3299.9" "3044.7" "2456.1" "2762.2" "3019.3" "3026.1" "2972.7" "3109.7" "3058.4" "3377.8" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "340.690" "51" "32" "327" "19" "724" "83.2" "5.03" "1099.60" "32" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Potential therapeutics for SARS; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Neutrophil degranulation; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "25" "14" "1.000" "1.036" "0.982" "0.999" "1.034" "0.983" "1.007" "1.006" "1.020" "16879.1" "16875.1" "17485.5" "16581.8" "16858.6" "17458.3" "16584.6" "16994.9" "16981.1" "17215.2" "" "" "" "" "" "" "" "" "" "" "16879.1" "14276.8" "11056.2" "12090.5" "13812.4" "13557.8" "12784.0" "14612.2" "13254.8" "15477.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "328.091" "34" "47" "106" "45" "1657" "189.1" "6.48" "379.76" "47" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "25" "2" "0.961" "1.053" "0.967" "0.943" "1.017" "0.954" "0.983" "0.993" "0.999" "6104.5" "5865.3" "6428.4" "5905.4" "5759.3" "6210.5" "5823.2" "6002.2" "6061.2" "6096.7" "" "" "" "" "" "" "" "" "" "" "6104.5" "4962.2" "4064.7" "4305.9" "4718.6" "4822.9" "4488.8" "5160.7" "4731.1" "5481.2" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "313.454" "58" "27" "313" "27" "531" "57.9" "7.84" "1037.94" "27" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation" "10" "0" "1.002" "1.103" "1.027" "0.991" "1.044" "0.971" "0.982" "1.089" "1.050" "12738.8" "12769.6" "14052.2" "13088.7" "12620.5" "13305.2" "12363.7" "12515.5" "13866.5" "13381.5" "" "" "" "" "" "" "" "" "" "" "12738.8" "10803.4" "8885.3" "9543.6" "10340.1" "10332.6" "9530.4" "10760.8" "10823.6" "12030.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "287.888" "47" "33" "112" "33" "840" "94.3" "5.19" "398.09" "33" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response" "3" "0" "1.016" "1.058" "0.983" "0.989" "1.015" "0.947" "0.985" "1.041" "1.018" "6741.0" "6847.9" "7130.0" "6623.8" "6665.0" "6842.8" "6384.2" "6642.9" "7018.9" "6865.5" "" "" "" "" "" "" "" "" "" "" "6741.0" "5793.5" "4508.4" "4829.7" "5460.7" "5314.0" "4921.2" "5711.5" "5478.7" "6172.4" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "287.349" "25" "55" "97" "54" "2363" "267.1" "5.02" "335.93" "55" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "29" "1" "1.022" "1.004" "1.058" "1.032" "1.037" "1.081" "1.032" "1.006" "1.004" "5331.2" "5446.1" "5352.6" "5638.6" "5499.8" "5530.8" "5765.3" "5500.0" "5361.7" "5353.9" "" "" "" "" "" "" "" "" "" "" "5331.2" "4607.5" "3384.5" "4111.4" "4506.0" "4295.1" "4444.1" "4728.9" "4185.1" "4813.5" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "281.976" "47" "30" "252" "16" "732" "84.6" "5.02" "857.29" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "71" "2" "0.986" "1.202" "0.953" "0.969" "1.135" "0.945" "0.982" "1.129" "1.011" "6639.3" "6545.1" "7978.2" "6327.5" "6432.2" "7532.5" "6274.5" "6522.8" "7496.1" "6710.1" "" "" "" "" "" "" "" "" "" "" "6639.3" "5537.3" "5044.6" "4613.7" "5270.0" "5849.6" "4836.7" "5608.3" "5851.2" "6032.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "277.788" "28" "40" "95" "40" "1675" "191.5" "5.69" "336.96" "40" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "25" "0" "1.067" "1.168" "1.006" "1.082" "1.145" "1.062" "1.050" "1.168" "1.122" "3566.7" "3804.7" "4164.8" "3586.4" "3859.0" "4082.4" "3786.5" "3744.0" "4165.6" "4002.3" "" "" "" "" "" "" "" "" "" "" "3566.7" "3218.9" "2633.4" "2615.0" "3161.7" "3170.3" "2918.8" "3219.1" "3251.5" "3598.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "272.092" "50" "26" "270" "21" "627" "70.2" "5.43" "838.63" "26" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "6" "1.053" "1.122" "1.063" "1.043" "1.079" "1.010" "1.041" "1.096" "1.082" "10528.3" "11087.2" "11816.3" "11194.1" "10983.7" "11356.3" "10631.5" "10956.6" "11539.2" "11386.5" "" "" "" "" "" "" "" "" "" "" "10528.3" "9380.1" "7471.5" "8162.2" "8999.0" "8819.1" "8195.2" "9420.5" "9007.1" "10237.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "265.211" "40" "40" "117" "40" "1101" "120.8" "7.33" "373.26" "40" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "10" "0" "0.994" "1.044" "0.965" "0.978" "0.964" "0.934" "0.992" "1.006" "1.007" "7762.7" "7714.1" "8106.3" "7494.1" "7591.5" "7482.6" "7253.4" "7704.0" "7809.4" "7816.7" "" "" "" "" "" "" "" "" "" "" "7762.7" "6526.3" "5125.7" "5464.3" "6219.8" "5810.9" "5591.2" "6623.9" "6095.7" "7027.7" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "260.440" "47" "26" "176" "16" "646" "70.9" "5.52" "596.52" "26" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Clathrin-mediated endocytosis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "27" "10" "1.002" "1.035" "0.974" "0.940" "1.010" "0.935" "0.959" "1.003" "0.990" "8690.4" "8711.9" "8991.4" "8464.6" "8168.7" "8774.1" "8122.8" "8335.5" "8713.1" "8599.2" "" "" "" "" "" "" "" "" "" "" "8690.4" "7370.5" "5685.3" "6171.9" "6692.7" "6813.8" "6261.4" "7166.8" "6801.1" "7731.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "255.050" "24" "42" "82" "42" "2225" "242.8" "6.46" "302.37" "42" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "Pyrimidine biosynthesis" "4" "0" "1.045" "0.781" "1.056" "1.025" "0.797" "1.024" "1.040" "0.778" "0.954" "4298.9" "4493.0" "3357.0" "4540.5" "4408.1" "3427.0" "4401.6" "4471.6" "3345.2" "4103.2" "" "" "" "" "" "" "" "" "" "" "4298.9" "3801.2" "2122.6" "3310.7" "3611.6" "2661.4" "3392.9" "3844.7" "2611.1" "3689.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "243.429" "42" "31" "143" "30" "803" "92.4" "4.84" "496.72" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "11" "0" "1.036" "1.039" "0.978" "1.017" "0.992" "1.009" "0.986" "0.993" "1.020" "8462.4" "8766.2" "8792.4" "8275.8" "8609.8" "8398.5" "8542.6" "8343.1" "8405.8" "8630.4" "" "" "" "" "" "" "" "" "" "" "8462.4" "7416.4" "5559.5" "6034.2" "7054.1" "6522.1" "6585.0" "7173.4" "6561.3" "7759.2" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "243.361" "50" "24" "134" "24" "573" "61.0" "5.87" "462.78" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "6" "0" "1.003" "1.068" "0.963" "0.974" "1.014" "0.961" "0.956" "1.013" "0.972" "8686.1" "8713.1" "9278.4" "8361.1" "8464.5" "8809.5" "8344.5" "8302.4" "8798.3" "8441.3" "" "" "" "" "" "" "" "" "" "" "8686.1" "7371.5" "5866.8" "6096.5" "6935.0" "6841.3" "6432.3" "7138.4" "6867.6" "7589.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "229.599" "21" "49" "57" "49" "2472" "284.4" "5.35" "198.58" "49" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Fas ligand pathway and stress induction of heat shock proteins" "RAF/MAP kinase cascade; Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "12" "0" "1.039" "1.210" "1.071" "1.036" "1.243" "1.047" "1.024" "1.241" "1.098" "3708.5" "3851.5" "4485.5" "3970.9" "3843.3" "4610.4" "3881.3" "3797.8" "4603.6" "4072.2" "" "" "" "" "" "" "" "" "" "" "3708.5" "3258.5" "2836.2" "2895.4" "3148.8" "3580.3" "2991.9" "3265.4" "3593.4" "3661.1" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "228.192" "19" "47" "61" "45" "3224" "358.0" "6.20" "212.67" "47" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "" "RHO GTPases Activate Formins; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Signaling by ALK fusions and activated point mutants" "35" "0" "0.983" "0.909" "1.062" "1.021" "0.918" "1.064" "1.061" "0.867" "0.961" "4018.4" "3949.8" "3652.4" "4267.8" "4101.4" "3689.1" "4275.0" "4265.1" "3484.6" "3863.6" "" "" "" "" "" "" "" "" "" "" "4018.4" "3341.6" "2309.4" "3111.8" "3360.3" "2864.9" "3295.3" "3667.1" "2719.9" "3473.6" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "220.480" "32" "44" "95" "44" "1394" "157.8" "6.13" "291.83" "44" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Ciliary landscape" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "5" "0" "1.025" "0.880" "1.034" "1.011" "0.822" "0.990" "0.989" "0.866" "0.966" "5976.9" "6127.7" "5258.6" "6180.6" "6039.8" "4911.4" "5916.6" "5908.3" "5176.5" "5771.2" "" "" "" "" "" "" "" "" "" "" "5976.9" "5184.2" "3325.0" "4506.5" "4948.4" "3814.1" "4560.8" "5079.9" "4040.6" "5188.6" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "216.748" "50" "17" "296" "7" "375" "41.7" "5.48" "1024.89" "17" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; RHO GTPases Activate Formins; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "157" "13" "1.026" "1.192" "1.027" "1.019" "1.164" "0.991" "1.026" "1.105" "1.018" "11684.0" "11991.0" "13928.5" "12000.3" "11910.2" "13605.8" "11573.6" "11990.7" "12912.1" "11895.0" "" "" "" "" "" "" "" "" "" "" "11684.0" "10144.7" "8807.1" "8750.0" "9758.1" "10566.0" "8921.4" "10309.6" "10078.7" "10694.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "212.531" "11" "42" "60" "42" "4374" "481.6" "5.22" "207.26" "42" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.037" "0.916" "1.058" "1.071" "0.918" "1.078" "1.089" "0.939" "0.986" "2636.9" "2733.3" "2416.5" "2789.8" "2825.0" "2421.4" "2841.5" "2872.7" "2476.3" "2599.0" "" "" "" "" "" "" "" "" "" "" "2636.9" "2312.5" "1528.0" "2034.2" "2314.5" "1880.4" "2190.3" "2469.9" "1932.9" "2336.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "211.637" "57" "28" "107" "28" "548" "59.6" "5.60" "371.50" "28" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "1.009" "1.025" "0.980" "0.956" "0.987" "0.963" "0.984" "0.991" "0.990" "6379.8" "6439.1" "6539.5" "6252.1" "6099.2" "6293.9" "6140.7" "6276.0" "6323.0" "6313.4" "" "" "" "" "" "" "" "" "" "" "6379.8" "5447.7" "4135.0" "4558.7" "4997.1" "4887.8" "4733.5" "5396.1" "4935.5" "5676.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "210.834" "50" "27" "83" "27" "645" "72.9" "5.07" "249.31" "27" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "1.001" "1.071" "0.981" "1.006" "1.024" "0.963" "0.985" "1.024" "0.999" "4334.1" "4336.8" "4641.0" "4252.5" "4360.6" "4440.2" "4171.5" "4269.7" "4436.5" "4330.5" "" "" "" "" "" "" "" "" "" "" "4334.1" "3669.0" "2934.5" "3100.7" "3572.7" "3448.2" "3215.6" "3671.1" "3463.0" "3893.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "209.137" "17" "43" "67" "43" "2671" "292.5" "7.43" "214.86" "43" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "1.027" "0.856" "1.030" "1.025" "0.850" "1.018" "1.043" "0.845" "0.976" "2617.1" "2686.6" "2241.5" "2695.5" "2681.6" "2224.6" "2664.5" "2729.9" "2210.4" "2555.1" "" "" "" "" "" "" "" "" "" "" "2617.1" "2272.9" "1417.3" "1965.4" "2197.1" "1727.6" "2053.9" "2347.1" "1725.4" "2297.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "208.544" "30" "25" "77" "25" "968" "106.7" "5.53" "249.44" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "IL-18 signaling pathway" "Cytosolic tRNA aminoacylation" "2" "0" "1.027" "0.967" "1.040" "1.013" "0.957" "0.978" "1.017" "0.936" "1.004" "3660.8" "3758.6" "3540.5" "3806.3" "3706.8" "3504.8" "3578.6" "3721.9" "3427.9" "3674.9" "" "" "" "" "" "" "" "" "" "" "3660.8" "3179.8" "2238.7" "2775.4" "3037.0" "2721.7" "2758.5" "3200.1" "2675.7" "3303.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "206.559" "55" "24" "80" "24" "592" "64.6" "6.71" "285.94" "24" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "One-carbon metabolism" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "3" "0" "1.026" "1.079" "1.047" "1.043" "1.101" "0.986" "1.015" "1.072" "1.071" "3992.4" "4094.6" "4306.8" "4178.7" "4165.6" "4394.1" "3935.4" "4053.4" "4279.9" "4275.4" "" "" "" "" "" "" "" "" "" "" "3992.4" "3464.1" "2723.2" "3046.9" "3412.9" "3412.4" "3033.5" "3485.1" "3340.8" "3843.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "206.239" "38" "26" "87" "26" "806" "89.3" "5.26" "311.51" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; E3 ubiquitin ligases ubiquitinate target proteins; Aggrephagy; Neutrophil degranulation; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; RHOH GTPase cycle; HSF1 activation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "21" "0" "1.029" "1.123" "1.026" "1.038" "1.083" "1.016" "1.026" "1.110" "1.083" "4195.8" "4316.5" "4713.2" "4304.4" "4357.2" "4545.5" "4264.9" "4306.2" "4657.5" "4542.9" "" "" "" "" "" "" "" "" "" "" "4195.8" "3651.8" "2980.2" "3138.5" "3569.9" "3529.9" "3287.5" "3702.5" "3635.4" "4084.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "205.764" "46" "24" "94" "21" "654" "72.3" "5.16" "324.53" "24" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "14" "0" "1.047" "1.114" "1.032" "1.100" "1.102" "1.039" "1.039" "1.091" "1.068" "4301.2" "4501.2" "4793.2" "4439.7" "4730.5" "4741.6" "4467.8" "4467.5" "4694.1" "4592.4" "" "" "" "" "" "" "" "" "" "" "4301.2" "3808.1" "3030.8" "3237.2" "3875.7" "3682.3" "3444.0" "3841.1" "3664.0" "4128.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "205.330" "24" "39" "81" "34" "1599" "175.4" "5.33" "243.14" "39" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Ribosomal scanning and start codon recognition; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "20" "4" "1.019" "1.042" "0.991" "1.032" "0.979" "1.011" "0.999" "0.988" "1.022" "3911.3" "3983.8" "4074.7" "3876.0" "4037.4" "3829.5" "3955.6" "3907.5" "3862.5" "3996.2" "" "" "" "" "" "" "" "" "" "" "3911.3" "3370.4" "2576.5" "2826.2" "3307.8" "2973.9" "3049.2" "3359.7" "3014.9" "3592.8" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "203.625" "18" "41" "62" "35" "2602" "278.0" "5.73" "213.52" "41" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "ISG15 antiviral mechanism" "6" "0" "0.958" "0.969" "0.989" "0.958" "0.956" "0.994" "0.993" "0.932" "0.983" "1626.1" "1557.1" "1575.3" "1608.3" "1557.9" "1554.1" "1616.4" "1615.0" "1515.2" "1598.2" "" "" "" "" "" "" "" "" "" "" "1626.1" "1317.4" "996.1" "1172.7" "1276.4" "1206.9" "1246.0" "1388.6" "1182.7" "1436.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "201.969" "37" "31" "75" "30" "935" "101.5" "7.30" "254.11" "31" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "Metabolism of folate and pterines" "6" "0" "0.995" "0.995" "1.069" "1.013" "1.001" "0.994" "0.944" "1.017" "0.988" "4741.9" "4717.6" "4717.7" "5069.9" "4804.2" "4746.7" "4714.4" "4476.5" "4823.7" "4683.9" "" "" "" "" "" "" "" "" "" "" "4741.9" "3991.2" "2983.0" "3696.7" "3936.1" "3686.2" "3634.0" "3848.9" "3765.2" "4211.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "201.900" "43" "29" "68" "29" "808" "90.9" "5.77" "234.48" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.009" "0.872" "0.973" "0.996" "0.891" "1.008" "1.029" "0.872" "0.983" "4009.4" "4045.7" "3497.7" "3900.7" "3991.3" "3574.0" "4042.3" "4126.7" "3497.3" "3943.2" "" "" "" "" "" "" "" "" "" "" "4009.4" "3422.8" "2211.6" "2844.2" "3270.1" "2775.5" "3115.9" "3548.1" "2729.9" "3545.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "201.750" "57" "19" "160" "16" "434" "47.1" "7.39" "535.25" "19" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "9" "3" "0.993" "1.078" "1.000" "0.956" "1.040" "0.941" "0.980" "1.073" "1.059" "8171.2" "8116.9" "8809.3" "8167.9" "7815.5" "8499.8" "7687.2" "8003.7" "8770.9" "8651.8" "" "" "" "" "" "" "" "" "" "" "8171.2" "6867.1" "5570.2" "5955.6" "6403.3" "6600.8" "5925.6" "6881.5" "6846.2" "7778.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "201.115" "55" "22" "72" "22" "535" "57.5" "6.46" "239.53" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "10" "0" "0.972" "1.004" "0.964" "0.936" "0.960" "0.946" "0.981" "0.953" "0.943" "4526.0" "4400.3" "4546.0" "4364.9" "4234.2" "4347.0" "4280.5" "4439.0" "4311.2" "4267.5" "" "" "" "" "" "" "" "" "" "" "4526.0" "3722.8" "2874.5" "3182.7" "3469.1" "3375.8" "3299.6" "3816.6" "3365.1" "3836.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "199.590" "9" "44" "61" "44" "5183" "573.5" "6.04" "200.72" "44" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.025" "1.011" "1.022" "1.030" "1.022" "1.047" "1.008" "0.984" "1.013" "2689.4" "2755.3" "2719.6" "2749.0" "2771.3" "2748.0" "2815.7" "2710.1" "2646.2" "2724.5" "" "" "" "" "" "" "" "" "" "" "2689.4" "2331.1" "1719.6" "2004.4" "2270.6" "2134.1" "2170.5" "2330.1" "2065.5" "2449.5" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "198.344" "42" "26" "58" "23" "644" "66.0" "8.12" "199.90" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Neutrophil degranulation" "4" "3" "0.309" "0.458" "0.243" "0.196" "0.266" "0.140" "0.188" "0.744" "0.148" "12939.0" "3995.0" "5928.1" "3148.2" "2532.7" "3447.9" "1808.1" "2436.0" "9629.2" "1921.1" "" "" "" "" "" "" "" "" "" "" "12939.0" "3379.8" "3748.4" "2295.5" "2075.0" "2677.6" "1393.8" "2094.5" "7516.2" "1727.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "197.054" "28" "33" "68" "33" "1197" "135.6" "8.43" "238.85" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Retinoblastoma gene in cancer" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "0.997" "0.802" "0.965" "0.987" "0.809" "0.966" "1.002" "0.807" "0.954" "4782.9" "4766.8" "3833.9" "4617.5" "4722.9" "3869.9" "4617.9" "4794.1" "3859.3" "4564.1" "" "" "" "" "" "" "" "" "" "" "4782.9" "4032.9" "2424.2" "3366.9" "3869.5" "3005.3" "3559.6" "4122.0" "3012.4" "4103.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "190.218" "28" "35" "86" "35" "1265" "147.8" "6.64" "258.32" "35" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "30" "0" "0.986" "0.973" "1.011" "1.020" "0.945" "0.969" "0.993" "0.982" "0.996" "4214.9" "4154.7" "4101.3" "4260.2" "4297.3" "3983.9" "4084.3" "4184.0" "4140.7" "4196.1" "" "" "" "" "" "" "" "" "" "" "4214.9" "3515.0" "2593.2" "3106.3" "3520.8" "3093.8" "3148.3" "3597.4" "3232.0" "3772.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5594688980084840223" "False" "High" "IsMasterProtein" "Q63HN8" "E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3" "0.000" "False" "187.213" "9" "44" "54" "44" "5207" "591.0" "6.48" "162.56" "44" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf20173" "57674" "ENSG00000173821" "RNF213" "C9JCP4; D6RI12; F8WKS1; hsa:57674; Q63HN8; Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; Q9H6C9; Q9H6H9; Q9H6P3; Q9H8A9; Q9HCF4; Q9HCL8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Signaling by ALK fusions and activated point mutants; Suppression of apoptosis" "3" "0" "1.044" "0.844" "1.048" "1.048" "0.886" "1.038" "1.024" "0.857" "0.999" "2025.8" "2115.1" "1709.1" "2123.7" "2122.1" "1794.9" "2101.9" "2074.2" "1736.3" "2024.2" "" "" "" "" "" "" "" "" "" "" "2025.8" "1789.4" "1080.6" "1548.5" "1738.7" "1393.9" "1620.2" "1783.4" "1355.3" "1819.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "184.828" "21" "21" "64" "21" "1332" "141.7" "8.06" "237.45" "21" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "" "Other interleukin signaling" "1" "0" "1.042" "1.063" "1.038" "0.991" "0.986" "0.968" "1.008" "1.027" "1.037" "2596.5" "2706.7" "2759.2" "2695.8" "2573.6" "2561.0" "2512.3" "2617.8" "2666.4" "2692.5" "" "" "" "" "" "" "" "" "" "" "2596.5" "2289.9" "1744.7" "1965.6" "2108.6" "1988.8" "1936.6" "2250.8" "2081.3" "2420.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "183.397" "20" "39" "56" "39" "2115" "238.1" "5.78" "189.68" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "5" "0" "0.991" "1.124" "1.010" "1.025" "1.156" "1.020" "1.063" "1.140" "1.034" "2813.5" "2787.0" "3161.8" "2840.8" "2882.6" "3252.0" "2870.4" "2989.4" "3207.3" "2909.0" "" "" "" "" "" "" "" "" "" "" "2813.5" "2357.9" "1999.2" "2071.3" "2361.7" "2525.4" "2212.6" "2570.3" "2503.5" "2615.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "181.607" "38" "29" "59" "19" "911" "104.8" "5.44" "197.50" "29" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "Platelet degranulation ; Nephrin family interactions" "9" "8" "1.008" "1.142" "1.027" "1.021" "1.092" "1.006" "0.994" "1.110" "1.061" "2661.6" "2683.9" "3038.2" "2734.1" "2717.9" "2906.4" "2676.8" "2645.5" "2953.1" "2823.5" "" "" "" "" "" "" "" "" "" "" "2661.6" "2270.6" "1921.1" "1993.5" "2226.8" "2257.1" "2063.4" "2274.6" "2305.1" "2538.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "179.953" "35" "22" "74" "21" "679" "73.6" "6.16" "271.81" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "7" "0" "1.026" "1.072" "0.953" "1.035" "0.999" "0.995" "1.013" "0.976" "0.990" "5530.6" "5675.0" "5926.6" "5269.1" "5726.6" "5527.1" "5500.7" "5600.9" "5400.0" "5475.6" "" "" "" "" "" "" "" "" "" "" "5530.6" "4801.2" "3747.4" "3841.9" "4691.8" "4292.3" "4240.2" "4815.6" "4215.0" "4922.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "179.179" "31" "24" "64" "22" "858" "96.8" "5.39" "212.45" "24" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "2" "2" "1.002" "0.902" "1.005" "0.992" "0.893" "0.962" "1.002" "0.906" "0.954" "3860.9" "3867.3" "3484.0" "3881.4" "3829.3" "3447.7" "3714.7" "3868.7" "3498.2" "3682.4" "" "" "" "" "" "" "" "" "" "" "3860.9" "3271.8" "2203.0" "2830.1" "3137.4" "2677.4" "2863.4" "3326.3" "2730.6" "3310.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "178.964" "59" "20" "98" "16" "417" "44.6" "8.10" "348.97" "20" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "13" "4" "0.972" "1.097" "1.014" "0.972" "1.041" "0.971" "0.947" "1.059" "1.025" "5300.7" "5151.6" "5813.1" "5374.2" "5151.8" "5519.5" "5149.6" "5022.2" "5611.8" "5432.7" "" "" "" "" "" "" "" "" "" "" "5300.7" "4358.4" "3675.6" "3918.6" "4220.9" "4286.3" "3969.5" "4318.1" "4380.4" "4884.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "175.572" "44" "24" "72" "24" "545" "60.5" "6.49" "236.55" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "1.000" "0.994" "1.010" "0.997" "0.953" "0.981" "1.006" "0.970" "0.991" "4893.5" "4893.9" "4864.8" "4941.2" "4879.8" "4664.4" "4801.9" "4921.8" "4746.8" "4850.0" "" "" "" "" "" "" "" "" "" "" "4893.5" "4140.4" "3076.0" "3602.9" "3998.0" "3622.3" "3701.5" "4231.8" "3705.1" "4360.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "174.079" "31" "25" "113" "24" "858" "95.3" "6.83" "338.87" "25" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "9" "1" "1.052" "1.069" "1.009" "1.006" "1.050" "1.005" "0.999" "1.056" "1.050" "6140.3" "6461.5" "6563.3" "6195.3" "6180.0" "6447.8" "6172.0" "6132.6" "6482.9" "6445.6" "" "" "" "" "" "" "" "" "" "" "6140.3" "5466.6" "4150.0" "4517.3" "5063.3" "5007.2" "4757.6" "5272.8" "5060.3" "5794.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "173.886" "25" "28" "50" "28" "1262" "144.4" "6.15" "171.49" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.025" "0.934" "1.023" "1.049" "0.944" "1.035" "1.053" "0.967" "1.047" "2287.9" "2346.0" "2137.0" "2341.3" "2399.8" "2160.6" "2368.8" "2409.1" "2213.5" "2395.9" "" "" "" "" "" "" "" "" "" "" "2287.9" "1984.7" "1351.2" "1707.2" "1966.2" "1677.9" "1826.0" "2071.4" "1727.8" "2154.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "173.656" "21" "30" "62" "29" "1512" "170.5" "7.33" "212.42" "30" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "6" "1" "0.976" "0.943" "0.980" "0.991" "0.935" "0.982" "1.001" "0.891" "0.963" "4382.6" "4277.9" "4131.3" "4296.1" "4344.2" "4098.4" "4305.1" "4387.8" "3902.9" "4222.5" "" "" "" "" "" "" "" "" "" "" "4382.6" "3619.2" "2612.3" "3132.5" "3559.2" "3182.8" "3318.5" "3772.6" "3046.5" "3796.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "173.640" "30" "35" "49" "35" "1217" "141.5" "7.18" "167.85" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "15" "0" "1.077" "0.851" "0.963" "1.058" "0.901" "0.950" "0.997" "0.868" "0.960" "2840.5" "3059.2" "2417.5" "2736.5" "3006.3" "2559.8" "2699.6" "2832.2" "2465.9" "2726.1" "" "" "" "" "" "" "" "" "" "" "2840.5" "2588.2" "1528.6" "1995.3" "2463.1" "1987.9" "2081.0" "2435.2" "1924.8" "2450.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "172.858" "43" "20" "81" "20" "543" "59.3" "7.65" "264.48" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "9" "0" "1.008" "1.044" "0.999" "1.014" "1.045" "1.019" "1.011" "1.029" "1.024" "3844.4" "3876.0" "4012.9" "3841.1" "3897.6" "4018.2" "3915.5" "3887.3" "3956.8" "3937.5" "" "" "" "" "" "" "" "" "" "" "3844.4" "3279.2" "2537.4" "2800.7" "3193.3" "3120.4" "3018.3" "3342.3" "3088.5" "3540.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "171.989" "26" "28" "66" "28" "1264" "140.4" "7.59" "222.81" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Amino acid metabolism" "Cytosolic tRNA aminoacylation" "2" "0" "1.019" "0.977" "1.008" "0.969" "0.963" "0.976" "0.991" "0.964" "0.991" "3794.8" "3866.6" "3709.2" "3824.7" "3677.8" "3654.8" "3704.0" "3760.7" "3658.5" "3760.2" "" "" "" "" "" "" "" "" "" "" "3794.8" "3271.2" "2345.4" "2788.8" "3013.3" "2838.3" "2855.2" "3233.4" "2855.7" "3380.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "171.840" "32" "24" "51" "24" "904" "101.8" "5.52" "180.02" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.049" "0.998" "0.995" "0.982" "1.018" "1.022" "0.995" "1.002" "0.980" "2509.3" "2631.5" "2505.3" "2497.5" "2464.8" "2555.0" "2563.5" "2498.0" "2515.1" "2458.1" "" "" "" "" "" "" "" "" "" "" "2509.3" "2226.4" "1584.1" "1821.1" "2019.5" "1984.2" "1976.0" "2147.8" "1963.2" "2210.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "169.734" "40" "21" "40" "16" "639" "65.4" "8.00" "149.80" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "" "Formation of the cornified envelope" "2" "3" "0.223" "0.219" "0.237" "0.189" "0.202" "0.156" "0.163" "0.960" "0.141" "6679.1" "1487.6" "1463.3" "1581.5" "1261.8" "1349.4" "1040.9" "1090.2" "6409.9" "942.5" "" "" "" "" "" "" "" "" "" "" "6679.1" "1258.5" "925.2" "1153.1" "1033.8" "1048.0" "802.3" "937.3" "5003.3" "847.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "169.601" "28" "25" "66" "25" "1058" "117.8" "5.76" "240.87" "25" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.012" "1.090" "1.009" "1.052" "1.027" "0.993" "1.087" "1.081" "1.064" "2654.4" "2686.6" "2893.9" "2679.4" "2792.8" "2727.3" "2634.7" "2886.6" "2869.6" "2825.1" "" "" "" "" "" "" "" "" "" "" "2654.4" "2272.9" "1829.8" "1953.7" "2288.1" "2117.9" "2030.9" "2481.9" "2239.9" "2539.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "167.416" "72" "16" "109" "13" "255" "29.2" "4.74" "333.46" "16" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RAB GEFs exchange GTP for GDP on RABs; Regulation of HSF1-mediated heat shock response; Signaling by Hippo; HSF1 activation; NADE modulates death signalling" "26" "4" "1.028" "1.067" "0.977" "1.019" "1.045" "0.992" "1.014" "1.041" "1.039" "4245.9" "4363.4" "4532.5" "4149.3" "4325.3" "4436.0" "4210.3" "4306.3" "4419.2" "4411.8" "" "" "" "" "" "" "" "" "" "" "4245.9" "3691.6" "2865.9" "3025.4" "3543.8" "3444.9" "3245.4" "3702.5" "3449.4" "3966.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "167.245" "25" "30" "52" "30" "1288" "147.1" "6.79" "189.38" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Ciliary landscape" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.008" "0.774" "1.011" "0.986" "0.813" "1.002" "1.042" "0.786" "0.959" "2992.8" "3017.1" "2316.5" "3025.1" "2951.7" "2433.9" "2998.4" "3119.3" "2352.6" "2869.4" "" "" "" "" "" "" "" "" "" "" "2992.8" "2552.5" "1464.7" "2205.8" "2418.3" "1890.1" "2311.3" "2682.0" "1836.4" "2579.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "162.084" "36" "33" "71" "28" "866" "101.2" "7.42" "212.28" "33" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "5" "1.013" "1.025" "1.012" "1.020" "1.013" "1.002" "1.019" "1.036" "1.044" "3740.6" "3788.0" "3834.1" "3786.0" "3817.0" "3787.8" "3749.2" "3813.4" "3875.8" "3906.1" "" "" "" "" "" "" "" "" "" "" "3740.6" "3204.8" "2424.3" "2760.6" "3127.3" "2941.5" "2890.1" "3278.8" "3025.3" "3511.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "160.745" "30" "27" "75" "27" "910" "101.9" "7.17" "252.57" "27" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "VEGFA-VEGFR2 signaling" "Signaling by BRAF and RAF1 fusions" "2" "0" "1.125" "1.143" "1.036" "1.102" "1.152" "1.015" "1.074" "1.180" "1.092" "3867.7" "4350.6" "4420.5" "4006.3" "4261.7" "4454.6" "3926.3" "4152.5" "4563.0" "4222.1" "" "" "" "" "" "" "" "" "" "" "3867.7" "3680.8" "2795.1" "2921.2" "3491.7" "3459.3" "3026.5" "3570.3" "3561.7" "3795.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "160.713" "47" "16" "150" "1" "451" "50.1" "5.06" "515.91" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; COPI-mediated anterograde transport; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "1" "1.017" "0.987" "1.059" "1.072" "1.060" "1.103" "1.102" "0.935" "1.096" "396.1" "403.0" "390.9" "419.7" "424.7" "420.0" "437.0" "436.6" "370.4" "434.0" "" "" "" "" "" "" "" "" "" "" "396.1" "340.9" "247.2" "306.0" "348.0" "326.2" "336.9" "375.4" "289.1" "390.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "160.118" "49" "21" "69" "21" "505" "56.7" "6.35" "225.46" "21" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "Prion disease pathway" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "4" "0" "0.995" "1.088" "0.984" "1.003" "1.040" "0.943" "1.018" "1.073" "1.054" "4498.0" "4476.2" "4894.9" "4425.8" "4512.0" "4676.1" "4241.0" "4581.2" "4825.8" "4742.4" "" "" "" "" "" "" "" "" "" "" "4498.0" "3787.0" "3095.1" "3227.1" "3696.7" "3631.3" "3269.1" "3938.9" "3766.8" "4263.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "160.039" "29" "21" "62" "21" "876" "97.1" "4.78" "201.92" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Apoptosis induced DNA fragmentation; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "15" "0" "1.006" "0.992" "1.010" "0.997" "0.947" "1.005" "1.054" "0.948" "0.987" "2906.8" "2923.8" "2884.3" "2936.8" "2898.7" "2753.0" "2920.8" "3064.6" "2755.9" "2868.2" "" "" "" "" "" "" "" "" "" "" "2906.8" "2473.6" "1823.7" "2141.4" "2374.9" "2138.0" "2251.5" "2635.0" "2151.1" "2578.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "159.166" "24" "29" "60" "29" "1230" "136.3" "5.78" "189.61" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Endoderm differentiation" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "4" "0" "1.011" "1.026" "1.025" "0.999" "1.009" "0.978" "1.006" "1.007" "1.078" "2154.0" "2178.7" "2210.3" "2208.0" "2152.2" "2172.6" "2105.9" "2166.8" "2168.6" "2321.2" "" "" "" "" "" "" "" "" "" "" "2154.0" "1843.3" "1397.6" "1609.9" "1763.3" "1687.2" "1623.3" "1863.0" "1692.7" "2086.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "158.552" "52" "20" "58" "20" "463" "51.1" "5.64" "192.29" "20" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "" "HATs acetylate histones; Telomere Extension By Telomerase" "2" "0" "1.020" "0.984" "0.986" "1.018" "0.942" "0.983" "1.023" "0.934" "0.965" "2446.3" "2494.9" "2407.6" "2413.1" "2490.7" "2305.5" "2405.7" "2502.8" "2284.3" "2359.6" "" "" "" "" "" "" "" "" "" "" "2446.3" "2110.8" "1522.3" "1759.5" "2040.7" "1790.4" "1854.4" "2151.9" "1783.0" "2121.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "155.678" "23" "28" "49" "28" "1309" "146.6" "6.13" "173.33" "28" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "Translation factors" "" "1" "0" "1.051" "1.008" "1.053" "1.048" "0.973" "1.058" "1.057" "1.001" "1.069" "2442.4" "2566.4" "2462.8" "2571.5" "2558.8" "2377.6" "2583.6" "2581.0" "2443.9" "2609.9" "" "" "" "" "" "" "" "" "" "" "2442.4" "2171.2" "1557.2" "1875.0" "2096.5" "1846.4" "1991.6" "2219.2" "1907.6" "2346.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "155.607" "24" "34" "57" "34" "1312" "153.8" "6.89" "186.90" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Sensing of DNA Double Strand Breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ)" "29" "0" "1.010" "0.761" "0.971" "0.988" "0.795" "0.943" "1.001" "0.766" "0.937" "4340.3" "4381.8" "3304.8" "4213.4" "4288.6" "3450.8" "4093.3" "4344.5" "3322.8" "4068.8" "" "" "" "" "" "" "" "" "" "" "4340.3" "3707.1" "2089.7" "3072.2" "3513.7" "2679.9" "3155.2" "3735.4" "2593.7" "3658.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "155.096" "44" "14" "133" "1" "445" "49.8" "4.89" "382.91" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "MHC class II antigen presentation; COPI-mediated anterograde transport; PKR-mediated signaling; Neutrophil degranulation; HCMV Early Events; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; Recycling pathway of L1; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Post-chaperonin tubulin folding pathway; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "42" "18" "1.017" "0.949" "1.023" "1.015" "0.939" "1.000" "1.000" "0.900" "0.931" "5370.9" "5462.5" "5098.8" "5496.0" "5449.6" "5044.5" "5372.9" "5368.8" "4831.5" "5001.5" "" "" "" "" "" "" "" "" "" "" "5370.9" "4621.4" "3224.0" "4007.4" "4464.9" "3917.4" "4141.6" "4616.0" "3771.3" "4496.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "154.727" "26" "24" "55" "24" "1014" "113.0" "8.88" "191.10" "24" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "25" "0" "1.030" "1.379" "1.020" "1.030" "1.360" "1.008" "1.064" "1.371" "1.170" "2715.1" "2796.7" "3742.8" "2770.2" "2796.3" "3693.6" "2737.1" "2888.9" "3721.5" "3175.4" "" "" "" "" "" "" "" "" "" "" "2715.1" "2366.1" "2366.6" "2019.9" "2291.0" "2868.4" "2109.9" "2483.8" "2904.8" "2854.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "151.823" "34" "23" "65" "23" "788" "85.2" "4.30" "217.19" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "0.990" "1.013" "1.026" "1.043" "1.007" "1.025" "1.009" "1.001" "1.016" "3846.3" "3806.8" "3896.3" "3944.4" "4010.9" "3873.1" "3942.1" "3881.9" "3851.6" "3909.4" "" "" "" "" "" "" "" "" "" "" "3846.3" "3220.7" "2463.6" "2876.1" "3286.2" "3007.8" "3038.7" "3337.7" "3006.4" "3514.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "151.046" "44" "14" "142" "3" "444" "49.6" "4.89" "430.05" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Potential therapeutics for SARS; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "57" "2" "1.038" "0.962" "0.931" "1.037" "0.996" "0.977" "1.024" "0.933" "1.016" "2381.4" "2472.7" "2291.1" "2218.0" "2468.6" "2372.7" "2326.2" "2437.5" "2222.8" "2419.8" "" "" "" "" "" "" "" "" "" "" "2381.4" "2091.9" "1448.7" "1617.3" "2022.6" "1842.6" "1793.1" "2095.7" "1735.0" "2175.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "148.333" "11" "28" "36" "28" "3051" "330.3" "5.08" "128.37" "28" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.009" "0.951" "1.000" "1.006" "1.019" "1.039" "0.975" "0.985" "0.977" "1721.4" "1737.7" "1636.3" "1721.9" "1731.8" "1754.1" "1788.9" "1678.4" "1694.8" "1681.9" "" "" "" "" "" "" "" "" "" "" "1721.4" "1470.2" "1034.6" "1255.5" "1418.9" "1362.2" "1379.0" "1443.0" "1322.9" "1512.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "148.214" "19" "26" "35" "26" "1972" "213.4" "4.70" "125.50" "26" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "ATM signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "0.989" "0.947" "1.019" "1.042" "1.023" "1.068" "1.023" "0.952" "1.026" "1204.5" "1191.6" "1141.0" "1226.9" "1255.6" "1232.3" "1286.9" "1232.6" "1147.2" "1235.8" "" "" "" "" "" "" "" "" "" "" "1204.5" "1008.1" "721.4" "894.6" "1028.7" "957.0" "992.0" "1059.8" "895.4" "1111.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "148.155" "47" "16" "140" "2" "449" "49.9" "5.10" "479.45" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; HCMV Early Events; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "37" "14" "1.012" "0.968" "0.969" "1.008" "0.938" "0.968" "1.008" "0.915" "0.985" "6241.2" "6316.4" "6043.8" "6047.8" "6292.4" "5854.7" "6040.0" "6293.6" "5713.3" "6144.6" "" "" "" "" "" "" "" "" "" "" "6241.2" "5343.9" "3821.5" "4409.8" "5155.4" "4546.7" "4655.9" "5411.2" "4459.6" "5524.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "146.651" "33" "18" "89" "18" "609" "69.8" "6.64" "327.18" "18" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "1.035" "1.060" "1.015" "1.050" "1.003" "1.000" "1.017" "1.016" "1.064" "4619.8" "4781.6" "4897.9" "4687.5" "4849.6" "4633.9" "4617.7" "4698.2" "4694.7" "4915.8" "" "" "" "" "" "" "" "" "" "" "4619.8" "4045.4" "3097.0" "3417.9" "3973.3" "3598.6" "3559.5" "4039.5" "3664.5" "4419.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "145.012" "41" "20" "42" "16" "584" "58.8" "5.21" "158.06" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "" "Formation of the cornified envelope" "2" "3" "0.208" "0.198" "0.231" "0.198" "0.225" "0.147" "0.168" "1.068" "0.122" "7120.2" "1479.7" "1410.8" "1644.2" "1412.2" "1604.2" "1049.6" "1195.6" "7601.2" "871.5" "" "" "" "" "" "" "" "" "" "" "7120.2" "1251.8" "892.1" "1198.8" "1157.0" "1245.8" "809.1" "1027.9" "5933.2" "783.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "142.096" "23" "23" "51" "23" "1152" "120.9" "5.43" "166.96" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "" "2" "0" "0.975" "1.023" "0.984" "0.987" "0.981" "1.010" "1.001" "0.940" "0.946" "3189.5" "3110.6" "3261.4" "3138.3" "3147.6" "3127.6" "3222.5" "3191.2" "2999.4" "3016.6" "" "" "" "" "" "" "" "" "" "" "3189.5" "2631.6" "2062.2" "2288.3" "2578.8" "2428.9" "2484.1" "2743.7" "2341.2" "2712.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "141.513" "46" "26" "67" "26" "543" "62.6" "6.80" "200.42" "26" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "VEGFA-VEGFR2 signaling" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "3" "0" "0.991" "1.064" "0.953" "0.979" "1.046" "0.973" "0.982" "1.008" "0.983" "5143.7" "5096.6" "5474.9" "4904.4" "5035.1" "5381.0" "5003.3" "5052.4" "5184.7" "5054.7" "" "" "" "" "" "" "" "" "" "" "5143.7" "4311.8" "3461.8" "3576.0" "4125.3" "4178.8" "3856.7" "4344.1" "4047.0" "4544.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "141.247" "31" "25" "101" "25" "710" "76.6" "4.70" "301.18" "25" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "4" "0" "1.034" "1.202" "0.987" "0.986" "1.158" "1.000" "0.926" "1.175" "1.110" "6263.3" "6478.9" "7528.6" "6183.8" "6177.2" "7255.9" "6266.1" "5798.8" "7362.3" "6950.6" "" "" "" "" "" "" "" "" "" "" "6263.3" "5481.3" "4760.4" "4508.9" "5061.0" "5634.8" "4830.1" "4985.8" "5746.8" "6249.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "141.231" "16" "26" "43" "22" "1912" "217.9" "5.86" "140.98" "26" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Rett syndrome; Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "9" "2" "1.013" "0.860" "1.003" "1.058" "0.898" "1.043" "1.039" "0.886" "0.913" "2516.6" "2548.1" "2165.4" "2525.3" "2663.7" "2259.0" "2624.4" "2614.3" "2228.7" "2298.3" "" "" "" "" "" "" "" "" "" "" "2516.6" "2155.7" "1369.2" "1841.3" "2182.4" "1754.3" "2023.0" "2247.8" "1739.6" "2066.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "140.865" "38" "17" "66" "17" "548" "62.9" "6.25" "220.84" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Photodynamic therapy-induced unfolded protein response" "Cytosolic tRNA aminoacylation" "2" "0" "1.079" "1.148" "1.005" "1.008" "0.989" "0.920" "1.009" "1.077" "1.064" "2754.0" "2970.5" "3161.2" "2767.3" "2775.3" "2722.7" "2532.9" "2779.3" "2966.6" "2929.7" "" "" "" "" "" "" "" "" "" "" "2754.0" "2513.1" "1998.9" "2017.7" "2273.9" "2114.4" "1952.5" "2389.7" "2315.6" "2634.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "139.947" "40" "22" "71" "21" "704" "80.1" "8.21" "265.71" "22" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "Respiratory electron transport" "4" "0" "1.017" "1.053" "1.017" "0.976" "1.025" "0.985" "0.980" "1.023" "1.022" "1965.1" "1998.6" "2069.7" "1998.0" "1917.4" "2014.0" "1934.8" "1924.8" "2009.4" "2008.2" "" "" "" "" "" "" "" "" "" "" "1965.1" "1690.9" "1308.7" "1456.9" "1570.9" "1564.1" "1491.4" "1655.0" "1568.5" "1805.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "138.429" "45" "14" "116" "3" "444" "49.6" "4.88" "319.01" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "41" "0" "0.986" "1.019" "0.928" "0.970" "0.968" "0.938" "1.006" "0.928" "0.933" "572.9" "564.7" "583.9" "531.9" "555.5" "554.8" "537.6" "576.4" "531.5" "534.7" "" "" "" "" "" "" "" "" "" "" "572.9" "477.7" "369.2" "387.8" "455.1" "430.8" "414.4" "495.6" "414.9" "480.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "137.948" "30" "20" "44" "20" "780" "85.4" "7.61" "150.15" "20" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.986" "1.056" "0.989" "0.994" "1.065" "0.979" "0.996" "1.049" "1.041" "1901.2" "1874.9" "2007.6" "1880.5" "1890.1" "2024.1" "1861.7" "1892.9" "1995.2" "1980.0" "" "" "" "" "" "" "" "" "" "" "1901.2" "1586.2" "1269.4" "1371.1" "1548.6" "1571.9" "1435.1" "1627.5" "1557.4" "1780.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "137.462" "43" "18" "96" "18" "463" "50.9" "5.54" "276.57" "18" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; HCMV Late Events; SUMOylation of RNA binding proteins; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "1.058" "0.975" "1.007" "1.024" "0.950" "1.001" "0.999" "0.924" "0.967" "5187.2" "5489.8" "5058.2" "5224.1" "5310.7" "4927.5" "5191.5" "5182.6" "4791.8" "5015.8" "" "" "" "" "" "" "" "" "" "" "5187.2" "4644.5" "3198.4" "3809.1" "4351.1" "3826.6" "4001.8" "4456.0" "3740.3" "4509.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "137.285" "21" "22" "39" "22" "1462" "165.8" "5.85" "139.92" "22" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "0.966" "0.775" "0.961" "0.965" "0.822" "0.951" "0.952" "0.769" "0.879" "2477.8" "2392.7" "1919.1" "2380.5" "2392.2" "2036.5" "2355.7" "2358.2" "1906.1" "2177.4" "" "" "" "" "" "" "" "" "" "" "2477.8" "2024.3" "1213.5" "1735.8" "1960.0" "1581.5" "1815.8" "2027.5" "1487.8" "1957.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "136.220" "24" "29" "47" "29" "1268" "141.4" "6.87" "150.91" "29" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "2q37 copy number variation syndrome" "HDL clearance" "2" "0" "1.045" "0.845" "1.055" "1.088" "0.890" "1.011" "1.075" "0.841" "0.977" "2354.7" "2460.3" "1988.7" "2483.8" "2562.4" "2095.1" "2381.3" "2531.5" "1980.8" "2300.8" "" "" "" "" "" "" "" "" "" "" "2354.7" "2081.4" "1257.5" "1811.1" "2099.4" "1627.0" "1835.6" "2176.6" "1546.1" "2068.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "135.855" "52" "25" "61" "24" "539" "57.9" "7.83" "201.69" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "1" "1.001" "1.006" "0.996" "0.964" "0.978" "0.963" "0.966" "1.015" "1.012" "2942.4" "2945.6" "2961.2" "2930.3" "2835.6" "2879.1" "2835.0" "2841.4" "2985.9" "2977.2" "" "" "" "" "" "" "" "" "" "" "2942.4" "2492.1" "1872.4" "2136.6" "2323.2" "2235.9" "2185.3" "2443.1" "2330.7" "2676.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361994698644895597" "False" "High" "IsMasterProtein" "P07355" "Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2" "0.000" "False" "135.700" "52" "17" "65" "17" "339" "38.6" "7.75" "227.56" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "302" "ENSG00000182718" "ANXA2" "hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8" "Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot" "7" "0" "1.091" "1.103" "1.014" "1.048" "1.082" "0.960" "1.047" "1.091" "1.094" "3062.7" "3341.2" "3379.0" "3105.3" "3209.2" "3313.4" "2940.0" "3206.5" "3340.3" "3350.1" "" "" "" "" "" "" "" "" "" "" "3062.7" "2826.7" "2136.6" "2264.2" "2629.3" "2573.1" "2266.3" "2757.0" "2607.3" "3011.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "135.567" "26" "32" "42" "32" "1233" "143.1" "7.64" "134.38" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "Estrogen-dependent gene expression; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "22" "0" "1.066" "0.899" "0.962" "1.031" "0.890" "0.933" "1.022" "0.895" "0.919" "2088.1" "2226.5" "1877.4" "2008.4" "2153.2" "1859.2" "1948.6" "2134.2" "1868.6" "1919.4" "" "" "" "" "" "" "" "" "" "" "2088.1" "1883.7" "1187.1" "1464.4" "1764.2" "1443.8" "1502.0" "1835.0" "1458.6" "1725.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "134.520" "27" "20" "63" "20" "835" "88.5" "5.77" "213.53" "20" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "SUMOylation of transcription cofactors; Generic Transcription Pathway; HCMV Early Events" "6" "0" "1.027" "0.838" "1.006" "0.998" "0.795" "0.981" "0.995" "0.831" "0.923" "3202.2" "3288.8" "2683.8" "3222.8" "3194.5" "2545.3" "3139.9" "3184.9" "2660.6" "2955.3" "" "" "" "" "" "" "" "" "" "" "3202.2" "2782.4" "1697.0" "2349.9" "2617.2" "1976.7" "2420.4" "2738.4" "2076.8" "2657.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "134.224" "39" "17" "97" "16" "461" "51.0" "6.68" "324.13" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "16p11.2 proximal deletion syndrome" "Prevention of phagosomal-lysosomal fusion" "2" "0" "1.021" "1.043" "1.036" "0.993" "0.999" "0.962" "0.998" "1.032" "1.068" "6113.6" "6244.0" "6376.8" "6334.4" "6069.7" "6107.1" "5880.2" "6100.3" "6309.0" "6530.3" "" "" "" "" "" "" "" "" "" "" "6113.6" "5282.6" "4032.1" "4618.7" "4972.9" "4742.6" "4532.7" "5245.0" "4924.6" "5871.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "134.049" "23" "33" "44" "33" "1488" "152.0" "9.04" "142.87" "33" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "1.029" "1.161" "0.972" "0.978" "1.095" "0.972" "0.955" "1.132" "1.031" "2250.8" "2315.0" "2612.9" "2187.5" "2202.2" "2464.9" "2188.9" "2149.4" "2548.2" "2321.1" "" "" "" "" "" "" "" "" "" "" "2250.8" "1958.5" "1652.2" "1595.0" "1804.3" "1914.2" "1687.3" "1848.0" "1989.1" "2086.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "134.019" "26" "22" "44" "22" "1010" "107.7" "6.70" "152.24" "22" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "4" "0" "1.035" "0.884" "0.989" "0.963" "0.877" "0.938" "0.969" "0.911" "0.989" "3167.5" "3278.7" "2799.0" "3132.0" "3048.9" "2777.8" "2970.4" "3070.0" "2885.2" "3132.0" "" "" "" "" "" "" "" "" "" "" "3167.5" "2773.8" "1769.9" "2283.7" "2498.0" "2157.2" "2289.7" "2639.6" "2252.1" "2815.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "134.004" "36" "16" "87" "16" "417" "48.1" "4.44" "288.36" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "13" "0" "1.042" "1.002" "1.041" "0.936" "0.987" "0.875" "0.951" "1.001" "0.988" "5869.8" "6116.6" "5879.7" "6111.6" "5496.0" "5793.5" "5138.9" "5585.1" "5873.2" "5797.4" "" "" "" "" "" "" "" "" "" "" "5869.8" "5174.8" "3717.8" "4456.2" "4502.9" "4499.1" "3961.3" "4802.1" "4584.4" "5212.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "133.897" "42" "18" "48" "18" "572" "62.3" "6.38" "168.26" "18" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "Recycling pathway of L1; CRMPs in Sema3A signaling" "4" "0" "0.953" "1.081" "0.947" "0.993" "0.997" "0.933" "0.966" "1.013" "0.997" "2161.0" "2059.4" "2335.0" "2045.9" "2146.4" "2153.5" "2016.7" "2087.7" "2189.0" "2153.6" "" "" "" "" "" "" "" "" "" "" "2161.0" "1742.3" "1476.4" "1491.8" "1758.6" "1672.4" "1554.6" "1795.0" "1708.7" "1936.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "133.850" "31" "12" "44" "12" "529" "56.5" "5.40" "149.11" "12" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "8" "0" "1.141" "1.249" "1.156" "1.125" "1.305" "1.213" "1.186" "1.217" "1.152" "1630.7" "1861.5" "2037.3" "1884.6" "1835.2" "2128.3" "1977.8" "1933.4" "1984.6" "1878.1" "" "" "" "" "" "" "" "" "" "" "1630.7" "1574.9" "1288.2" "1374.2" "1503.6" "1652.8" "1524.6" "1662.4" "1549.1" "1688.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "133.062" "23" "27" "67" "27" "1140" "126.9" "5.26" "196.51" "27" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Formation of TC-NER Pre-Incision Complex; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "14" "0" "1.025" "1.029" "0.984" "0.987" "0.987" "0.993" "1.014" "0.995" "0.988" "3242.0" "3322.6" "3335.3" "3190.3" "3199.5" "3201.2" "3218.9" "3286.2" "3225.1" "3203.0" "" "" "" "" "" "" "" "" "" "" "3242.0" "2811.0" "2108.9" "2326.2" "2621.3" "2486.0" "2481.3" "2825.5" "2517.4" "2879.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "133.050" "17" "20" "35" "20" "1393" "154.2" "7.88" "122.10" "20" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "0.975" "0.990" "1.037" "0.982" "0.979" "1.055" "1.039" "0.955" "0.995" "1614.5" "1573.8" "1598.9" "1674.3" "1586.1" "1580.1" "1703.2" "1676.8" "1542.3" "1606.2" "" "" "" "" "" "" "" "" "" "" "1614.5" "1331.4" "1011.0" "1220.8" "1299.5" "1227.1" "1312.9" "1441.7" "1203.9" "1444.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "132.987" "17" "19" "29" "17" "1337" "150.7" "7.91" "122.50" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "2" "1.071" "0.799" "1.004" "1.053" "0.846" "0.969" "0.970" "0.839" "0.959" "1199.1" "1284.5" "958.6" "1204.4" "1262.5" "1014.0" "1162.4" "1163.0" "1006.0" "1150.5" "" "" "" "" "" "" "" "" "" "" "1199.1" "1086.7" "606.1" "878.2" "1034.4" "787.5" "896.0" "1000.0" "785.3" "1034.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "132.963" "28" "24" "44" "24" "868" "96.0" "6.52" "135.52" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "5" "0" "0.993" "0.969" "0.985" "0.958" "0.999" "0.957" "0.960" "1.029" "0.993" "1944.2" "1930.1" "1884.1" "1915.2" "1862.7" "1941.5" "1860.4" "1866.4" "2000.3" "1930.5" "" "" "" "" "" "" "" "" "" "" "1944.2" "1632.9" "1191.3" "1396.5" "1526.1" "1507.7" "1434.1" "1604.7" "1561.3" "1735.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "132.481" "28" "22" "43" "21" "900" "96.7" "6.25" "150.47" "22" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "PKMTs methylate histone lysines; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "43" "1" "0.993" "0.781" "0.961" "0.966" "0.787" "0.973" "1.024" "0.750" "0.916" "2732.2" "2712.3" "2133.3" "2625.0" "2638.1" "2151.2" "2657.7" "2796.4" "2049.6" "2502.7" "" "" "" "" "" "" "" "" "" "" "2732.2" "2294.6" "1348.9" "1914.0" "2161.4" "1670.6" "2048.6" "2404.3" "1599.9" "2250.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "132.399" "37" "19" "59" "19" "556" "60.3" "6.11" "181.23" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "1.004" "0.992" "1.048" "0.947" "0.980" "0.998" "0.978" "1.004" "0.997" "2640.3" "2651.9" "2619.0" "2767.4" "2500.8" "2587.7" "2634.9" "2583.3" "2651.2" "2631.8" "" "" "" "" "" "" "" "" "" "" "2640.3" "2243.6" "1656.0" "2017.9" "2048.9" "2009.5" "2031.1" "2221.1" "2069.4" "2366.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "132.299" "31" "21" "45" "14" "729" "80.2" "8.27" "157.82" "21" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "Novel intracellular components of RIG-I-like receptor pathway" "SUMOylation of transcription cofactors" "2" "5" "1.093" "1.260" "1.012" "1.112" "1.309" "1.054" "1.070" "1.251" "1.119" "2116.8" "2313.5" "2667.4" "2143.2" "2354.6" "2771.5" "2230.5" "2266.0" "2648.1" "2368.9" "" "" "" "" "" "" "" "" "" "" "2116.8" "1957.3" "1686.6" "1562.7" "1929.1" "2152.3" "1719.3" "1948.3" "2067.0" "2129.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "132.235" "13" "27" "39" "27" "2032" "225.4" "7.80" "128.77" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "4p16.3 copy number variation" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "1.000" "1.085" "0.963" "0.974" "1.070" "0.933" "0.956" "1.056" "0.992" "2149.8" "2150.9" "2332.4" "2071.2" "2093.2" "2300.3" "2005.0" "2055.1" "2269.5" "2131.7" "" "" "" "" "" "" "" "" "" "" "2149.8" "1819.7" "1474.8" "1510.2" "1715.0" "1786.3" "1545.5" "1767.0" "1771.5" "1916.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "132.195" "39" "15" "80" "7" "406" "46.1" "5.48" "249.70" "15" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "10" "1.016" "0.902" "0.960" "0.970" "0.839" "0.973" "1.010" "0.831" "0.953" "4406.2" "4478.5" "3976.4" "4231.1" "4275.8" "3696.7" "4287.9" "4448.8" "3659.7" "4199.2" "" "" "" "" "" "" "" "" "" "" "4406.2" "3788.9" "2514.3" "3085.1" "3503.2" "2870.8" "3305.3" "3825.1" "2856.6" "3775.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "132.114" "16" "29" "53" "29" "1830" "211.8" "6.87" "146.41" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Chemokine signaling pathway" "Neutrophil degranulation; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "8" "0" "1.032" "0.841" "1.013" "1.041" "0.849" "1.057" "1.042" "0.800" "0.920" "1893.1" "1952.8" "1592.5" "1918.1" "1970.7" "1607.0" "2000.5" "1972.6" "1513.7" "1742.6" "" "" "" "" "" "" "" "" "" "" "1893.1" "1652.1" "1006.9" "1398.6" "1614.6" "1248.0" "1542.1" "1696.1" "1181.6" "1566.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8201100139023696608" "False" "High" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "0.000" "False" "132.030" "16" "23" "31" "23" "1782" "191.4" "4.41" "109.84" "23" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "G protein signaling pathways" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "0.974" "0.996" "0.974" "0.936" "0.957" "0.984" "0.975" "0.967" "0.932" "1681.1" "1637.2" "1675.1" "1636.8" "1573.9" "1608.4" "1654.4" "1639.4" "1625.5" "1567.6" "" "" "" "" "" "" "" "" "" "" "1681.1" "1385.1" "1059.2" "1193.5" "1289.5" "1249.1" "1275.2" "1409.5" "1268.8" "1409.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "131.084" "23" "23" "36" "23" "1129" "124.3" "6.61" "125.28" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Pathophysiological roles of DUX4 in FSHD1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "3" "0" "1.025" "0.942" "0.951" "0.979" "0.938" "0.986" "0.955" "0.966" "0.938" "2192.2" "2247.3" "2065.0" "2085.7" "2146.9" "2056.0" "2162.6" "2093.3" "2117.6" "2057.3" "" "" "" "" "" "" "" "" "" "" "2192.2" "1901.2" "1305.7" "1520.8" "1759.0" "1596.6" "1667.0" "1799.8" "1653.0" "1849.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "130.746" "13" "30" "42" "30" "2376" "266.8" "7.11" "122.41" "30" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.057" "0.933" "1.075" "1.069" "0.998" "1.035" "1.061" "1.021" "1.038" "1132.7" "1197.3" "1056.6" "1217.1" "1211.0" "1130.6" "1171.9" "1202.1" "1156.6" "1176.2" "" "" "" "" "" "" "" "" "" "" "1132.7" "1013.0" "668.1" "887.4" "992.2" "878.0" "903.3" "1033.5" "902.8" "1057.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5003304044033613110" "False" "High" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "0.000" "False" "129.901" "33" "14" "46" "14" "533" "56.6" "6.71" "176.58" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "5" "0" "0.994" "0.817" "1.025" "1.010" "0.848" "1.012" "1.022" "0.841" "0.996" "2171.2" "2158.8" "1773.6" "2225.3" "2193.3" "1841.9" "2197.9" "2220.0" "1826.3" "2163.6" "" "" "" "" "" "" "" "" "" "" "2171.2" "1826.4" "1121.5" "1622.5" "1797.0" "1430.4" "1694.2" "1908.8" "1425.6" "1945.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "129.650" "31" "26" "51" "26" "821" "92.8" "5.41" "171.32" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.034" "1.020" "0.989" "0.990" "0.979" "1.001" "0.996" "0.981" "1.014" "3227.9" "3338.8" "3294.0" "3193.7" "3194.7" "3160.0" "3229.7" "3215.3" "3167.0" "3273.0" "" "" "" "" "" "" "" "" "" "" "3227.9" "2824.7" "2082.8" "2328.7" "2617.4" "2454.0" "2489.6" "2764.6" "2472.1" "2942.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7883409800749118824" "False" "High" "IsMasterProtein" "Q7KZ85" "Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2" "0.000" "False" "129.271" "16" "20" "37" "20" "1726" "198.9" "4.91" "126.20" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674" "6830" "ENSG00000109111" "SUPT6H" "A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "1.052" "0.986" "1.130" "1.088" "1.058" "1.097" "1.065" "1.027" "1.002" "1290.0" "1357.5" "1271.8" "1457.8" "1403.0" "1365.4" "1415.1" "1373.8" "1325.3" "1292.4" "" "" "" "" "" "" "" "" "" "" "1290.0" "1148.5" "804.2" "1063.0" "1149.5" "1060.4" "1090.8" "1181.2" "1034.5" "1161.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "128.466" "33" "19" "42" "19" "737" "82.5" "5.10" "155.03" "19" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "" "Neddylation; KEAP1-NFE2L2 pathway" "2" "0" "1.031" "1.085" "1.039" "0.990" "1.076" "0.979" "1.022" "1.085" "1.074" "2757.7" "2842.8" "2993.3" "2864.0" "2729.7" "2967.2" "2700.1" "2818.1" "2992.1" "2961.8" "" "" "" "" "" "" "" "" "" "" "2757.7" "2405.1" "1892.7" "2088.3" "2236.4" "2304.3" "2081.3" "2423.0" "2335.5" "2662.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "128.268" "24" "26" "34" "26" "1134" "123.7" "5.66" "119.36" "26" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "1.019" "1.087" "1.048" "1.001" "1.044" "0.993" "1.012" "1.110" "1.051" "1507.3" "1536.4" "1637.7" "1578.9" "1508.3" "1573.4" "1497.4" "1524.6" "1672.7" "1584.1" "" "" "" "" "" "" "" "" "" "" "1507.3" "1299.8" "1035.5" "1151.2" "1235.8" "1221.9" "1154.2" "1310.9" "1305.6" "1424.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "128.160" "13" "27" "35" "25" "2364" "274.4" "5.57" "111.02" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RHOV GTPase cycle; RHOU GTPase cycle; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "12" "1" "1.049" "1.188" "1.143" "1.167" "1.223" "1.134" "1.085" "1.204" "1.125" "901.1" "944.9" "1070.6" "1029.8" "1051.2" "1102.3" "1022.1" "978.0" "1085.0" "1013.6" "" "" "" "" "" "" "" "" "" "" "901.1" "799.4" "677.0" "750.9" "861.3" "856.0" "787.8" "840.8" "846.9" "911.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "127.876" "44" "26" "53" "25" "607" "69.2" "6.18" "163.11" "26" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "0" "0.689" "0.688" "0.753" "0.644" "0.867" "0.601" "0.594" "1.013" "0.733" "3823.9" "2633.7" "2631.5" "2878.8" "2464.2" "3314.5" "2297.2" "2273.1" "3873.7" "2802.7" "" "" "" "" "" "" "" "" "" "" "3823.9" "2228.2" "1663.9" "2099.0" "2018.9" "2574.0" "1770.8" "1954.4" "3023.7" "2519.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "127.800" "47" "17" "91" "14" "364" "39.4" "8.09" "327.31" "17" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "11" "3" "1.020" "1.135" "1.088" "1.017" "1.132" "0.998" "1.030" "1.138" "1.064" "5475.8" "5583.3" "6216.7" "5959.2" "5569.0" "6196.8" "5465.8" "5637.4" "6233.5" "5828.5" "" "" "" "" "" "" "" "" "" "" "5475.8" "4723.6" "3930.8" "4345.1" "4562.7" "4812.3" "4213.3" "4847.1" "4865.6" "5240.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "127.245" "42" "15" "79" "5" "448" "49.9" "5.06" "265.69" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; RHO GTPases Activate Formins; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "160" "0" "0.951" "0.891" "1.007" "0.953" "0.833" "0.970" "0.943" "0.868" "0.932" "1123.4" "1068.3" "1001.3" "1131.4" "1070.1" "935.4" "1090.2" "1059.5" "974.8" "1047.0" "" "" "" "" "" "" "" "" "" "" "1123.4" "903.8" "633.1" "824.9" "876.8" "726.4" "840.4" "911.0" "760.9" "941.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "127.095" "20" "24" "44" "24" "1224" "138.3" "7.66" "143.99" "24" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.999" "0.962" "0.976" "1.018" "0.972" "0.960" "0.987" "0.928" "0.993" "2963.6" "2962.1" "2850.4" "2894.0" "3017.3" "2881.0" "2845.3" "2925.5" "2751.3" "2942.2" "" "" "" "" "" "" "" "" "" "" "2963.6" "2506.0" "1802.3" "2110.1" "2472.1" "2237.3" "2193.2" "2515.3" "2147.6" "2645.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "126.782" "26" "26" "49" "26" "971" "110.3" "5.77" "166.55" "26" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "0.967" "0.963" "0.948" "0.940" "0.921" "0.955" "0.968" "0.918" "0.959" "3405.7" "3293.2" "3278.5" "3228.6" "3200.2" "3138.0" "3250.9" "3295.4" "3127.4" "3267.4" "" "" "" "" "" "" "" "" "" "" "3405.7" "2786.1" "2073.0" "2354.1" "2622.0" "2436.9" "2505.9" "2833.4" "2441.1" "2937.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "126.764" "39" "26" "50" "26" "730" "77.5" "8.70" "144.01" "26" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.030" "0.853" "1.031" "1.026" "0.815" "1.070" "1.028" "0.801" "0.879" "2536.7" "2613.1" "2163.1" "2615.5" "2602.3" "2068.7" "2714.7" "2607.9" "2031.7" "2230.5" "" "" "" "" "" "" "" "" "" "" "2536.7" "2210.8" "1367.7" "1907.1" "2132.1" "1606.5" "2092.6" "2242.3" "1585.9" "2005.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "125.928" "24" "27" "41" "26" "1189" "133.2" "7.59" "132.79" "27" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "13" "1" "1.018" "0.849" "1.010" "1.010" "0.849" "1.016" "1.034" "0.827" "0.955" "2097.0" "2134.7" "1781.0" "2118.3" "2117.0" "1781.0" "2131.0" "2169.2" "1735.1" "2003.3" "" "" "" "" "" "" "" "" "" "" "2097.0" "1806.0" "1126.1" "1544.5" "1734.5" "1383.1" "1642.7" "1865.1" "1354.3" "1801.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "125.556" "39" "24" "66" "18" "577" "67.8" "6.40" "210.97" "24" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "10" "5" "1.027" "1.274" "1.037" "1.052" "1.168" "0.988" "1.010" "1.235" "1.119" "3298.7" "3386.7" "4203.9" "3421.2" "3469.3" "3852.6" "3258.6" "3330.9" "4073.2" "3690.8" "" "" "" "" "" "" "" "" "" "" "3298.7" "2865.2" "2658.2" "2494.6" "2842.5" "2991.9" "2511.9" "2863.9" "3179.3" "3318.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "125.029" "32" "20" "39" "20" "693" "76.7" "6.87" "132.57" "20" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "2" "0" "1.031" "1.085" "0.939" "0.994" "0.945" "0.943" "0.981" "1.019" "1.027" "2868.4" "2957.6" "3113.0" "2693.8" "2852.0" "2711.1" "2704.7" "2814.9" "2923.5" "2945.0" "" "" "" "" "" "" "" "" "" "" "2868.4" "2502.2" "1968.3" "1964.2" "2336.7" "2105.4" "2084.9" "2420.2" "2281.9" "2647.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "125.019" "47" "13" "129" "13" "335" "36.0" "8.46" "432.49" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glycolysis; Gluconeogenesis" "16" "0" "1.022" "1.118" "0.981" "0.962" "1.037" "0.895" "0.963" "1.061" "0.985" "5369.9" "5490.6" "6002.9" "5269.2" "5166.8" "5567.3" "4807.8" "5168.7" "5695.0" "5291.6" "" "" "" "" "" "" "" "" "" "" "5369.9" "4645.2" "3795.7" "3842.0" "4233.2" "4323.5" "3706.0" "4444.1" "4445.3" "4757.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "124.824" "47" "19" "71" "19" "459" "51.8" "5.43" "214.12" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Androgen receptor signaling pathway" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "6" "0" "0.959" "1.010" "0.991" "0.941" "0.992" "0.956" "0.965" "0.991" "0.970" "3557.3" "3413.0" "3594.6" "3525.6" "3346.2" "3527.6" "3401.5" "3433.5" "3525.4" "3451.6" "" "" "" "" "" "" "" "" "" "" "3557.3" "2887.5" "2272.9" "2570.7" "2741.5" "2739.5" "2622.0" "2952.1" "2751.8" "3103.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "124.214" "68" "14" "80" "14" "249" "26.7" "6.90" "294.45" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "10" "0" "0.977" "1.117" "1.027" "0.992" "1.052" "0.980" "0.979" "1.109" "1.070" "2945.8" "2878.8" "3291.4" "3025.5" "2922.5" "3100.4" "2886.2" "2884.8" "3266.4" "3152.6" "" "" "" "" "" "" "" "" "" "" "2945.8" "2435.5" "2081.2" "2206.0" "2394.4" "2407.7" "2224.8" "2480.4" "2549.6" "2834.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "123.582" "38" "14" "63" "6" "407" "46.4" "5.48" "191.79" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Z-decay: degradation of maternal mRNAs by zygotically expressed factors; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "11" "0" "0.950" "1.008" "0.918" "1.014" "1.007" "0.913" "0.984" "0.903" "1.019" "599.3" "569.4" "604.1" "549.9" "607.6" "603.6" "546.9" "589.7" "541.0" "610.8" "" "" "" "" "" "" "" "" "" "" "599.3" "481.8" "382.0" "401.0" "497.8" "468.7" "421.5" "507.0" "422.3" "549.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "123.533" "22" "35" "63" "35" "1382" "166.5" "6.79" "184.53" "35" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.018" "1.149" "1.010" "1.070" "1.155" "1.071" "1.104" "1.115" "1.015" "2126.1" "2164.6" "2443.0" "2147.6" "2274.0" "2456.0" "2276.1" "2347.7" "2370.1" "2158.6" "" "" "" "" "" "" "" "" "" "" "2126.1" "1831.3" "1544.7" "1565.9" "1863.1" "1907.2" "1754.5" "2018.5" "1850.0" "1940.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "123.388" "23" "17" "41" "17" "953" "105.8" "5.39" "126.88" "17" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Downstream TCR signaling; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "64" "0" "1.012" "0.992" "1.027" "1.001" "0.959" "1.026" "0.996" "0.932" "0.946" "2252.9" "2281.0" "2235.5" "2312.6" "2255.0" "2161.0" "2310.4" "2245.0" "2100.4" "2131.1" "" "" "" "" "" "" "" "" "" "" "2252.9" "1929.8" "1413.5" "1686.2" "1847.5" "1678.2" "1781.0" "1930.2" "1639.5" "1916.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "122.480" "37" "16" "46" "15" "504" "56.0" "8.53" "155.25" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "13" "0" "1.062" "1.138" "0.935" "0.984" "1.098" "0.994" "1.006" "1.092" "1.035" "1706.4" "1812.8" "1941.7" "1595.3" "1678.4" "1873.3" "1695.4" "1717.4" "1863.5" "1765.5" "" "" "" "" "" "" "" "" "" "" "1706.4" "1533.7" "1227.8" "1163.2" "1375.1" "1454.8" "1306.9" "1476.6" "1454.6" "1587.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "122.147" "24" "20" "32" "20" "963" "109.6" "6.51" "113.19" "20" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "11" "0" "1.038" "0.967" "0.980" "0.963" "0.953" "0.991" "1.005" "0.958" "0.992" "1285.9" "1335.3" "1244.0" "1259.5" "1238.7" "1225.8" "1274.5" "1291.9" "1232.3" "1275.2" "" "" "" "" "" "" "" "" "" "" "1285.9" "1129.7" "786.6" "918.4" "1014.9" "951.9" "982.5" "1110.8" "961.9" "1146.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "121.852" "41" "16" "61" "12" "445" "50.6" "6.47" "182.29" "16" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "2" "4" "1.012" "1.139" "0.985" "1.024" "1.068" "0.947" "1.031" "1.099" "1.060" "3798.1" "3843.0" "4325.1" "3740.3" "3888.1" "4056.0" "3597.7" "3914.6" "4172.9" "4025.9" "" "" "" "" "" "" "" "" "" "" "3798.1" "3251.3" "2734.8" "2727.2" "3185.5" "3149.8" "2773.3" "3365.7" "3257.2" "3619.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "121.810" "33" "16" "34" "16" "649" "71.4" "4.45" "136.62" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "5q35 copy number variation" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5" "0" "1.044" "1.040" "1.051" "1.108" "1.037" "1.072" "1.130" "1.015" "1.068" "1971.7" "2058.8" "2049.8" "2072.7" "2183.9" "2045.5" "2112.8" "2227.8" "2000.6" "2105.8" "" "" "" "" "" "" "" "" "" "" "1971.7" "1741.8" "1296.1" "1511.3" "1789.3" "1588.5" "1628.7" "1915.4" "1561.6" "1893.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "121.694" "35" "21" "43" "14" "614" "69.1" "8.92" "144.05" "21" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "Ciliary landscape" "Estrogen-dependent gene expression; SUMOylation of transcription cofactors; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "6" "0" "1.045" "1.040" "0.994" "1.068" "1.146" "1.084" "1.090" "1.133" "1.073" "1289.9" "1348.4" "1341.3" "1282.2" "1377.8" "1478.7" "1397.8" "1406.1" "1460.8" "1384.1" "" "" "" "" "" "" "" "" "" "" "1289.9" "1140.8" "848.1" "934.9" "1128.8" "1148.3" "1077.5" "1209.0" "1140.3" "1244.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "121.666" "33" "11" "42" "11" "440" "48.1" "5.08" "150.08" "11" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "1.005" "1.057" "1.061" "1.101" "1.032" "1.014" "1.057" "1.063" "1.121" "1625.8" "1633.9" "1718.8" "1724.6" "1790.3" "1678.3" "1647.8" "1718.3" "1727.6" "1821.8" "" "" "" "" "" "" "" "" "" "" "1625.8" "1382.3" "1086.8" "1257.5" "1466.8" "1303.3" "1270.2" "1477.4" "1348.5" "1637.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "121.087" "19" "9" "218" "9" "653" "68.1" "7.24" "805.60" "9" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "1.046" "1.208" "1.266" "1.053" "1.559" "1.143" "1.076" "1.259" "1.027" "7500.7" "7848.3" "9063.6" "9493.5" "7899.6" "11690.5" "8571.8" "8073.5" "9444.0" "7703.7" "" "" "" "" "" "" "" "" "" "" "7500.7" "6639.9" "5731.0" "6922.2" "6472.2" "9078.6" "6607.5" "6941.6" "7371.6" "6926.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "120.843" "73" "15" "48" "14" "240" "26.8" "4.73" "178.09" "15" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes" "2" "1" "0.983" "1.140" "0.964" "0.995" "1.108" "1.033" "0.946" "1.071" "1.038" "3404.7" "3347.3" "3880.8" "3282.1" "3386.8" "3772.7" "3518.7" "3219.4" "3645.6" "3535.7" "" "" "" "" "" "" "" "" "" "" "3404.7" "2831.9" "2453.9" "2393.1" "2774.8" "2929.8" "2712.4" "2768.0" "2845.6" "3178.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "120.639" "46" "19" "46" "19" "491" "55.5" "7.15" "167.45" "19" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "9" "0" "1.021" "1.105" "1.033" "1.003" "1.033" "0.956" "0.990" "1.053" "1.057" "3417.4" "3488.2" "3775.0" "3531.0" "3427.5" "3529.8" "3265.9" "3384.6" "3598.4" "3613.7" "" "" "" "" "" "" "" "" "" "" "3417.4" "2951.1" "2387.0" "2574.6" "2808.2" "2741.2" "2517.5" "2910.1" "2808.8" "3248.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "120.622" "9" "26" "35" "26" "3184" "353.4" "6.32" "118.09" "26" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "1.020" "0.840" "1.011" "1.006" "0.824" "0.932" "1.008" "0.823" "0.936" "1189.7" "1214.1" "999.1" "1203.3" "1197.0" "979.9" "1109.3" "1199.4" "979.7" "1113.3" "" "" "" "" "" "" "" "" "" "" "1189.7" "1027.2" "631.7" "877.4" "980.7" "761.0" "855.1" "1031.2" "764.7" "1000.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "120.538" "25" "18" "38" "18" "814" "92.4" "5.00" "137.12" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.030" "1.117" "1.059" "1.029" "1.084" "1.061" "1.070" "1.090" "1.109" "1755.8" "1808.8" "1960.8" "1858.8" "1807.4" "1903.8" "1862.4" "1878.7" "1914.2" "1948.1" "" "" "" "" "" "" "" "" "" "" "1755.8" "1530.3" "1239.8" "1355.3" "1480.8" "1478.4" "1435.6" "1615.3" "1494.2" "1751.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "120.412" "33" "19" "38" "17" "699" "78.8" "7.11" "128.70" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "UDP-derived sugars synthesis in fibroblasts" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "4" "2" "1.032" "0.973" "1.032" "1.046" "0.962" "1.000" "1.047" "0.920" "1.061" "1366.9" "1411.0" "1329.5" "1411.1" "1429.2" "1315.5" "1367.4" "1431.2" "1257.1" "1450.9" "" "" "" "" "" "" "" "" "" "" "1366.9" "1193.7" "840.7" "1028.9" "1171.0" "1021.6" "1054.0" "1230.6" "981.3" "1304.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "120.302" "36" "21" "61" "20" "541" "59.6" "5.66" "196.27" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.984" "1.037" "1.003" "0.949" "0.985" "0.961" "0.960" "0.977" "0.959" "4371.7" "4302.9" "4532.8" "4385.9" "4150.3" "4305.2" "4199.0" "4195.8" "4269.9" "4192.9" "" "" "" "" "" "" "" "" "" "" "4371.7" "3640.4" "2866.1" "3197.9" "3400.3" "3343.4" "3236.7" "3607.5" "3332.9" "3769.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "120.300" "34" "25" "38" "25" "755" "85.8" "4.40" "131.46" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "" "mRNA Splicing - Major Pathway" "1" "0" "1.088" "1.019" "0.990" "1.111" "0.993" "1.062" "1.066" "1.003" "1.046" "2804.6" "3052.3" "2857.9" "2777.9" "3116.9" "2783.6" "2979.5" "2990.7" "2812.0" "2934.8" "" "" "" "" "" "" "" "" "" "" "2804.6" "2582.3" "1807.0" "2025.5" "2553.7" "2161.7" "2296.7" "2571.4" "2194.9" "2638.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "119.563" "19" "22" "40" "22" "1272" "141.3" "5.41" "129.34" "22" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "14" "0" "1.029" "1.005" "0.980" "0.999" "0.967" "0.974" "1.008" "0.991" "0.972" "2239.4" "2305.5" "2250.3" "2195.6" "2236.5" "2166.4" "2181.1" "2257.6" "2218.8" "2176.7" "" "" "" "" "" "" "" "" "" "" "2239.4" "1950.5" "1422.9" "1600.9" "1832.3" "1682.4" "1681.2" "1941.1" "1731.9" "1957.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "119.366" "23" "23" "33" "23" "1249" "138.3" "6.32" "113.28" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.985" "1.050" "1.029" "1.011" "0.999" "0.988" "0.984" "0.999" "1.016" "1677.0" "1651.7" "1760.2" "1726.4" "1695.2" "1675.6" "1657.3" "1650.5" "1675.2" "1704.2" "" "" "" "" "" "" "" "" "" "" "1677.0" "1397.3" "1113.0" "1258.8" "1388.9" "1301.2" "1277.5" "1419.1" "1307.6" "1532.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "118.886" "23" "23" "37" "23" "1176" "134.4" "7.30" "117.22" "23" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.013" "0.927" "0.981" "0.995" "0.945" "0.996" "1.023" "0.932" "0.982" "1497.3" "1517.2" "1388.0" "1469.5" "1489.4" "1414.8" "1491.5" "1532.5" "1395.3" "1470.3" "" "" "" "" "" "" "" "" "" "" "1497.3" "1283.6" "877.6" "1071.5" "1220.3" "1098.7" "1149.7" "1317.6" "1089.1" "1321.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "118.758" "14" "23" "45" "13" "1976" "228.9" "5.54" "160.01" "23" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "Regulation of actin cytoskeleton" "EPHA-mediated growth cone collapse; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "7" "0" "1.076" "0.931" "1.156" "1.159" "1.002" "1.218" "1.147" "0.935" "1.057" "661.4" "711.9" "615.7" "764.5" "766.4" "662.6" "805.5" "758.8" "618.2" "699.3" "" "" "" "" "" "" "" "" "" "" "661.4" "602.3" "389.3" "557.4" "627.9" "514.6" "620.9" "652.4" "482.5" "628.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "118.546" "47" "22" "50" "22" "501" "57.1" "6.55" "166.93" "22" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Alanine and aspartate metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.045" "0.979" "1.044" "1.038" "0.999" "0.999" "1.036" "1.000" "1.024" "2510.8" "2623.1" "2457.2" "2620.5" "2606.8" "2508.7" "2507.2" "2601.9" "2510.9" "2570.6" "" "" "" "" "" "" "" "" "" "" "2510.8" "2219.2" "1553.7" "1910.7" "2135.8" "1948.2" "1932.7" "2237.1" "1959.9" "2311.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "118.510" "15" "24" "32" "24" "1616" "183.1" "7.75" "109.04" "24" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "13" "0" "1.025" "0.905" "1.042" "1.030" "0.840" "1.019" "1.049" "0.892" "0.969" "1727.9" "1771.8" "1564.0" "1800.5" "1778.9" "1452.2" "1761.5" "1811.9" "1540.8" "1674.1" "" "" "" "" "" "" "" "" "" "" "1727.9" "1499.0" "988.9" "1312.8" "1457.5" "1127.7" "1357.8" "1557.9" "1202.7" "1505.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "118.349" "32" "22" "58" "19" "711" "73.1" "7.30" "179.70" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "Pre-implantation embryo" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "3" "2" "1.047" "0.980" "0.994" "1.008" "0.931" "0.975" "0.963" "0.944" "1.012" "3120.8" "3267.4" "3058.0" "3101.9" "3146.9" "2904.4" "3042.8" "3006.8" "2946.2" "3159.2" "" "" "" "" "" "" "" "" "" "" "3120.8" "2764.3" "1933.6" "2261.8" "2578.3" "2255.5" "2345.5" "2585.2" "2299.7" "2840.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "118.206" "23" "17" "28" "17" "1087" "120.9" "5.06" "106.14" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "20" "0" "1.011" "1.005" "1.042" "1.025" "1.003" "1.023" "1.033" "0.970" "1.009" "954.7" "965.4" "959.5" "995.0" "979.0" "958.0" "977.1" "986.0" "926.1" "962.9" "" "" "" "" "" "" "" "" "" "" "954.7" "816.7" "606.7" "725.5" "802.1" "744.0" "753.2" "847.8" "722.9" "865.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "118.071" "22" "21" "32" "21" "1304" "145.7" "7.09" "125.39" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "5" "0" "0.986" "1.195" "0.985" "0.930" "1.169" "1.009" "0.996" "1.086" "1.019" "1617.5" "1595.2" "1932.3" "1592.5" "1503.7" "1890.3" "1632.3" "1610.9" "1757.4" "1648.1" "" "" "" "" "" "" "" "" "" "" "1617.5" "1349.6" "1221.8" "1161.1" "1232.0" "1468.0" "1258.3" "1385.0" "1371.7" "1481.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "117.936" "23" "24" "42" "17" "1105" "122.8" "5.76" "144.43" "24" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "3" "1.024" "0.939" "1.009" "0.985" "0.953" "1.003" "1.023" "0.927" "0.949" "2966.9" "3038.5" "2785.2" "2992.4" "2923.2" "2826.4" "2977.2" "3036.0" "2751.4" "2815.9" "" "" "" "" "" "" "" "" "" "" "2966.9" "2570.7" "1761.1" "2181.9" "2395.0" "2194.9" "2295.0" "2610.4" "2147.7" "2531.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "117.883" "27" "21" "40" "21" "999" "111.3" "5.22" "136.74" "21" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "3" "0" "1.054" "0.847" "1.005" "0.991" "0.872" "0.978" "0.991" "0.852" "0.986" "1863.9" "1965.0" "1578.0" "1872.8" "1847.7" "1625.1" "1823.6" "1846.2" "1587.6" "1837.0" "" "" "" "" "" "" "" "" "" "" "1863.9" "1662.5" "997.8" "1365.6" "1513.8" "1262.0" "1405.7" "1587.4" "1239.2" "1651.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "117.231" "35" "15" "50" "15" "455" "49.8" "7.61" "184.61" "15" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "16p11.2 distal deletion syndrome" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "3" "0" "1.046" "0.959" "0.975" "1.055" "0.953" "1.031" "1.015" "0.913" "1.013" "2973.7" "3110.3" "2851.5" "2899.1" "3136.0" "2834.3" "3065.7" "3018.0" "2715.9" "3012.7" "" "" "" "" "" "" "" "" "" "" "2973.7" "2631.4" "1803.0" "2113.9" "2569.4" "2201.0" "2363.2" "2594.9" "2120.0" "2708.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "117.170" "62" "12" "100" "8" "245" "27.7" "4.79" "301.61" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "40" "2" "0.996" "1.078" "1.022" "0.978" "1.103" "0.991" "1.029" "1.094" "1.079" "2892.8" "2880.6" "3118.2" "2956.9" "2828.1" "3190.9" "2866.3" "2977.2" "3164.4" "3121.6" "" "" "" "" "" "" "" "" "" "" "2892.8" "2437.1" "1971.7" "2156.0" "2317.1" "2478.0" "2209.4" "2559.8" "2470.0" "2806.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "116.892" "37" "19" "47" "19" "534" "60.9" "8.44" "139.53" "19" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.040" "0.989" "1.007" "1.011" "0.985" "1.038" "1.013" "0.976" "0.986" "2552.5" "2655.4" "2524.3" "2570.3" "2581.1" "2515.1" "2649.8" "2585.0" "2492.2" "2516.3" "" "" "" "" "" "" "" "" "" "" "2552.5" "2246.5" "1596.1" "1874.2" "2114.7" "1953.2" "2042.6" "2222.6" "1945.3" "2262.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "116.627" "33" "11" "84" "3" "450" "50.4" "4.93" "240.62" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Hedgehog 'off' state; Post-chaperonin tubulin folding pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC" "38" "0" "1.079" "1.139" "1.094" "0.972" "0.994" "0.956" "0.892" "1.083" "1.058" "150.9" "162.9" "171.9" "165.1" "146.7" "150.0" "144.3" "134.6" "163.4" "159.6" "" "" "" "" "" "" "" "" "" "" "150.9" "137.8" "108.7" "120.3" "120.2" "116.5" "111.3" "115.7" "127.5" "143.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "116.184" "32" "11" "116" "1" "445" "49.9" "4.89" "336.65" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Hedgehog 'off' state" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250102899765152791" "False" "High" "IsMasterProtein" "Q9BVA1" "Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1" "0.000" "False" "115.878" "32" "11" "116" "1" "445" "49.9" "4.89" "335.73" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347733" "ENSG00000137285" "TUBB2B" "A8K068; hsa:347733; Q9BVA1" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Recruitment of NuMA to mitotic centrosomes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recycling pathway of L1; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "35" "0" "0.671" "0.740" "0.563" "0.668" "1.014" "0.586" "0.591" "0.737" "0.922" "24.5" "16.5" "18.2" "13.8" "16.4" "24.9" "14.4" "14.5" "18.1" "22.6" "" "" "" "" "" "" "" "" "" "" "24.5" "13.9" "11.5" "10.1" "13.4" "19.3" "11.1" "12.5" "14.1" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "115.531" "33" "25" "41" "25" "736" "81.8" "6.81" "131.66" "25" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Synaptic vesicle pathway; CAMKK2 pathway" "Apoptotic execution phase" "3" "0" "0.996" "1.055" "1.034" "1.003" "0.986" "1.018" "1.017" "1.045" "1.007" "1756.6" "1749.7" "1854.0" "1817.1" "1761.4" "1732.4" "1787.6" "1785.6" "1836.2" "1768.9" "" "" "" "" "" "" "" "" "" "" "1756.6" "1480.3" "1172.3" "1324.9" "1443.1" "1345.3" "1378.0" "1535.3" "1433.3" "1590.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "114.277" "25" "20" "37" "19" "874" "97.7" "5.47" "128.91" "20" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "1" "1.025" "1.025" "1.006" "1.043" "0.956" "1.049" "1.010" "0.927" "0.964" "1798.9" "1844.7" "1844.7" "1809.9" "1876.6" "1718.9" "1887.8" "1817.7" "1667.2" "1733.3" "" "" "" "" "" "" "" "" "" "" "1798.9" "1560.7" "1166.4" "1319.7" "1537.5" "1334.9" "1455.2" "1562.9" "1301.3" "1558.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "113.869" "20" "22" "39" "22" "1217" "135.5" "5.26" "121.41" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.027" "0.980" "1.038" "1.002" "1.018" "1.016" "1.016" "0.986" "0.982" "2222.7" "2283.2" "2177.1" "2307.1" "2226.4" "2263.3" "2257.5" "2258.5" "2191.0" "2183.1" "" "" "" "" "" "" "" "" "" "" "2222.7" "1931.6" "1376.6" "1682.2" "1824.1" "1757.6" "1740.2" "1941.9" "1710.2" "1962.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "113.664" "27" "19" "43" "19" "760" "84.8" "6.61" "145.19" "19" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "21" "0" "0.973" "0.826" "0.977" "0.924" "0.782" "0.885" "0.975" "0.788" "0.951" "3408.0" "3316.5" "2815.7" "3331.2" "3150.1" "2666.4" "3017.4" "3321.8" "2684.6" "3239.6" "" "" "" "" "" "" "" "" "" "" "3408.0" "2805.8" "1780.4" "2429.0" "2580.9" "2070.7" "2325.9" "2856.1" "2095.5" "2912.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "113.515" "29" "24" "42" "24" "919" "103.2" "5.72" "134.86" "24" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.018" "1.053" "1.032" "0.978" "1.029" "0.956" "1.020" "1.033" "1.059" "2175.7" "2214.1" "2291.0" "2246.2" "2128.2" "2238.9" "2080.8" "2220.1" "2247.0" "2303.6" "" "" "" "" "" "" "" "" "" "" "2175.7" "1873.2" "1448.6" "1637.8" "1743.7" "1738.7" "1604.0" "1908.9" "1753.9" "2071.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "113.383" "37" "21" "50" "21" "585" "69.0" "5.87" "161.66" "21" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "3" "0" "1.009" "1.025" "1.024" "0.989" "1.045" "0.986" "1.017" "1.004" "0.970" "2798.9" "2825.4" "2869.7" "2865.2" "2769.2" "2924.0" "2758.9" "2846.4" "2808.8" "2714.9" "" "" "" "" "" "" "" "" "" "" "2798.9" "2390.4" "1814.5" "2089.1" "2268.8" "2270.7" "2126.7" "2447.4" "2192.4" "2440.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "113.363" "35" "22" "36" "18" "784" "85.5" "7.55" "116.81" "22" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "1" "1.024" "1.031" "1.012" "0.992" "0.989" "0.927" "1.001" "1.049" "1.019" "1334.9" "1366.4" "1375.6" "1350.3" "1324.8" "1320.9" "1237.1" "1336.3" "1400.7" "1359.7" "" "" "" "" "" "" "" "" "" "" "1334.9" "1156.0" "869.8" "984.6" "1085.4" "1025.8" "953.6" "1148.9" "1093.3" "1222.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "113.122" "46" "10" "46" "10" "289" "32.1" "6.95" "165.06" "10" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "6" "0" "0.986" "1.086" "1.047" "0.983" "1.094" "0.991" "0.978" "1.064" "1.031" "1757.0" "1733.0" "1908.9" "1839.7" "1727.3" "1923.0" "1741.1" "1718.7" "1869.5" "1810.9" "" "" "" "" "" "" "" "" "" "" "1757.0" "1466.1" "1207.0" "1341.4" "1415.2" "1493.4" "1342.1" "1477.7" "1459.2" "1628.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "113.070" "21" "19" "53" "18" "1097" "123.6" "4.94" "161.89" "19" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "" "vRNP Assembly" "1" "1" "0.992" "1.041" "1.001" "0.964" "0.974" "0.951" "0.987" "0.999" "1.010" "1774.5" "1759.6" "1846.7" "1775.9" "1710.9" "1727.6" "1687.6" "1752.1" "1772.1" "1792.7" "" "" "" "" "" "" "" "" "" "" "1774.5" "1488.7" "1167.7" "1294.9" "1401.7" "1341.6" "1300.9" "1506.4" "1383.2" "1611.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "112.396" "18" "17" "32" "16" "1101" "118.5" "4.81" "102.98" "17" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "" "RHOU GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "1" "1.017" "1.048" "1.031" "1.066" "1.130" "1.121" "1.135" "1.083" "1.005" "993.9" "1010.8" "1042.0" "1024.9" "1059.5" "1123.1" "1114.2" "1127.9" "1076.4" "998.4" "" "" "" "" "" "" "" "" "" "" "993.9" "855.1" "658.9" "747.3" "868.1" "872.2" "858.9" "969.8" "840.2" "897.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "112.177" "32" "18" "56" "17" "508" "57.1" "4.87" "173.82" "18" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling; Chylomicron assembly; VLDL assembly; LDL remodeling" "13" "0" "1.012" "1.073" "1.003" "1.047" "1.026" "1.008" "1.000" "0.995" "1.023" "3343.9" "3384.4" "3589.1" "3355.6" "3502.7" "3431.0" "3371.4" "3345.2" "3326.6" "3420.0" "" "" "" "" "" "" "" "" "" "" "3343.9" "2863.3" "2269.4" "2446.7" "2869.7" "2664.4" "2598.8" "2876.2" "2596.6" "3074.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "111.935" "26" "21" "41" "21" "863" "96.5" "6.74" "124.83" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.054" "0.989" "1.023" "1.008" "0.974" "0.991" "1.048" "0.941" "1.002" "1610.3" "1696.8" "1592.7" "1646.8" "1622.9" "1568.2" "1596.6" "1687.4" "1515.7" "1613.4" "" "" "" "" "" "" "" "" "" "" "1610.3" "1435.5" "1007.1" "1200.8" "1329.6" "1217.9" "1230.7" "1450.8" "1183.1" "1450.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "111.324" "13" "26" "33" "26" "2136" "244.4" "6.06" "101.58" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "2q11.2 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.977" "0.991" "0.960" "0.995" "0.974" "1.022" "1.006" "0.948" "0.979" "1691.1" "1652.9" "1676.4" "1623.1" "1682.0" "1646.5" "1727.8" "1700.6" "1603.4" "1655.1" "" "" "" "" "" "" "" "" "" "" "1691.1" "1398.4" "1060.0" "1183.5" "1378.1" "1278.7" "1331.9" "1462.1" "1251.5" "1488.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "110.154" "16" "21" "33" "21" "1508" "168.5" "6.62" "118.22" "21" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.015" "1.026" "0.985" "1.027" "1.000" "1.023" "1.059" "0.998" "1.057" "1428.0" "1449.0" "1465.9" "1406.2" "1466.4" "1427.6" "1461.2" "1512.0" "1424.5" "1509.4" "" "" "" "" "" "" "" "" "" "" "1428.0" "1225.9" "926.9" "1025.3" "1201.4" "1108.6" "1126.4" "1300.0" "1111.9" "1357.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "109.982" "18" "20" "32" "19" "1220" "138.7" "5.49" "110.79" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "Translation factors; Ciliary landscape" "GTP hydrolysis and joining of the 60S ribosomal subunit" "3" "0" "1.041" "1.097" "0.961" "0.993" "1.120" "0.975" "0.988" "1.124" "1.015" "2331.1" "2426.5" "2556.3" "2240.3" "2315.4" "2610.3" "2272.4" "2302.6" "2619.1" "2365.7" "" "" "" "" "" "" "" "" "" "" "2331.1" "2052.9" "1616.4" "1633.5" "1897.0" "2027.1" "1751.6" "1979.8" "2044.3" "2126.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534557055474382647" "False" "High" "IsMasterProtein" "P63267" "Actin, gamma-enteric smooth muscle OS=Homo sapiens OX=9606 GN=ACTG2 PE=1 SV=1" "0.000" "True" "109.743" "28" "11" "192" "2" "376" "41.9" "5.48" "596.29" "11" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "72" "ENSG00000163017" "ACTG2" "B2R7E7; B4E315; D6W5H8; E9PG30; hsa:72; P12718; P63267; Q504R1; Q6FI22" "Common pathways underlying drug addiction; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "Smooth Muscle Contraction" "4" "0" "0.993" "1.168" "0.964" "0.971" "1.047" "0.934" "1.016" "1.014" "0.951" "1284.7" "1276.2" "1500.7" "1238.5" "1247.0" "1345.7" "1199.9" "1305.6" "1302.6" "1222.0" "" "" "" "" "" "" "" "" "" "" "1284.7" "1079.7" "948.9" "903.0" "1021.7" "1045.0" "924.9" "1122.5" "1016.7" "1098.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "109.491" "33" "17" "34" "17" "617" "68.3" "5.52" "118.37" "17" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.001" "1.030" "0.979" "0.936" "0.942" "0.912" "0.982" "1.025" "0.965" "1582.8" "1584.9" "1630.6" "1549.6" "1482.0" "1490.3" "1443.3" "1554.3" "1622.3" "1526.9" "" "" "" "" "" "" "" "" "" "" "1582.8" "1340.8" "1031.0" "1129.9" "1214.2" "1157.3" "1112.6" "1336.4" "1266.3" "1372.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "109.310" "18" "22" "32" "21" "1401" "157.1" "6.61" "117.58" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "" "Condensation of Prometaphase Chromosomes" "1" "1" "0.969" "0.721" "0.982" "0.970" "0.738" "0.972" "1.008" "0.711" "0.895" "1509.7" "1462.5" "1089.2" "1482.0" "1465.2" "1114.2" "1467.5" "1521.4" "1073.4" "1351.7" "" "" "" "" "" "" "" "" "" "" "1509.7" "1237.3" "688.7" "1080.6" "1200.4" "865.2" "1131.2" "1308.1" "837.8" "1215.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "109.143" "44" "13" "47" "13" "338" "35.5" "8.68" "159.10" "13" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "Gluconeogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "10" "0" "0.883" "0.992" "0.896" "0.854" "0.959" "0.810" "0.869" "1.111" "0.899" "3743.7" "3306.3" "3714.9" "3352.8" "3198.6" "3591.9" "3033.0" "3253.2" "4159.3" "3364.2" "" "" "" "" "" "" "" "" "" "" "3743.7" "2797.2" "2349.0" "2444.7" "2620.6" "2789.4" "2338.0" "2797.1" "3246.6" "3024.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3264594850844257822" "False" "High" "IsMasterProtein" "P50440" "Glycine amidinotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GATM PE=1 SV=1" "0.000" "False" "109.136" "35" "13" "34" "13" "423" "48.4" "8.05" "114.67" "13" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "2628" "ENSG00000171766" "GATM" "B4DH99; B4DPI3; hsa:2628; P50440; Q53EQ4" "Creatine pathway" "Creatine metabolism" "2" "0" "0.971" "1.032" "0.935" "0.932" "0.990" "0.910" "0.932" "1.008" "1.041" "1683.0" "1633.4" "1736.3" "1574.4" "1569.1" "1665.8" "1532.3" "1568.9" "1696.9" "1752.4" "" "" "" "" "" "" "" "" "" "" "1683.0" "1381.9" "1097.9" "1148.0" "1285.6" "1293.6" "1181.2" "1349.0" "1324.5" "1575.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "108.952" "26" "13" "29" "13" "587" "63.5" "4.68" "104.34" "13" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "12" "0" "1.052" "1.020" "1.052" "1.032" "0.979" "1.073" "1.065" "0.977" "1.059" "1575.3" "1657.6" "1607.2" "1656.8" "1626.0" "1542.2" "1690.0" "1677.8" "1539.4" "1668.7" "" "" "" "" "" "" "" "" "" "" "1575.3" "1402.3" "1016.2" "1208.1" "1332.2" "1197.6" "1302.7" "1442.6" "1201.6" "1500.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "108.798" "29" "24" "35" "24" "819" "93.4" "5.72" "113.04" "24" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "" "ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; HCMV Early Events; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.985" "0.837" "0.962" "0.966" "0.786" "0.992" "0.988" "0.795" "0.913" "1347.3" "1326.7" "1127.6" "1296.0" "1301.6" "1058.9" "1336.4" "1331.0" "1070.8" "1230.3" "" "" "" "" "" "" "" "" "" "" "1347.3" "1122.4" "713.0" "945.0" "1066.4" "822.3" "1030.1" "1144.4" "835.9" "1106.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.000" "False" "108.670" "35" "23" "42" "23" "645" "73.4" "6.37" "135.33" "23" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "" "RAC1 GTPase cycle" "1" "0" "0.978" "0.974" "0.998" "0.994" "0.944" "1.015" "0.977" "0.930" "0.984" "3265.5" "3192.0" "3182.1" "3257.7" "3245.0" "3082.9" "3314.6" "3190.2" "3037.0" "3214.6" "" "" "" "" "" "" "" "" "" "" "3265.5" "2700.5" "2012.1" "2375.3" "2658.6" "2394.1" "2555.1" "2742.9" "2370.6" "2890.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "108.638" "26" "15" "35" "15" "732" "81.2" "5.48" "123.68" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "" "Neutrophil degranulation; Eukaryotic Translation Termination" "2" "0" "0.983" "1.003" "1.025" "0.947" "0.992" "0.945" "0.966" "1.082" "1.023" "1510.2" "1485.1" "1515.4" "1547.3" "1430.5" "1497.9" "1427.6" "1458.2" "1634.7" "1544.3" "" "" "" "" "" "" "" "" "" "" "1510.2" "1256.5" "958.2" "1128.2" "1172.0" "1163.2" "1100.5" "1253.8" "1276.0" "1388.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "108.636" "22" "22" "37" "22" "963" "109.9" "5.57" "110.36" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.018" "0.820" "1.007" "0.988" "0.814" "0.997" "0.973" "0.817" "0.905" "2395.1" "2438.2" "1964.6" "2412.2" "2365.6" "1950.3" "2387.6" "2329.8" "1957.5" "2168.6" "" "" "" "" "" "" "" "" "" "" "2395.1" "2062.8" "1242.3" "1758.9" "1938.2" "1514.6" "1840.4" "2003.1" "1527.9" "1949.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "108.438" "35" "11" "83" "10" "334" "36.6" "6.05" "283.49" "11" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Pyruvate metabolism" "5" "0" "0.987" "1.040" "0.952" "0.939" "1.036" "0.888" "0.969" "1.051" "1.089" "6404.9" "6324.2" "6662.9" "6098.2" "6013.7" "6634.0" "5688.4" "6207.6" "6732.7" "6972.9" "" "" "" "" "" "" "" "" "" "" "6404.9" "5350.4" "4213.0" "4446.5" "4927.0" "5151.9" "4384.8" "5337.3" "5255.3" "6269.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "108.408" "25" "16" "30" "16" "734" "82.2" "8.37" "109.04" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "10" "0" "1.082" "0.900" "1.057" "1.048" "0.922" "1.026" "1.028" "0.921" "0.957" "1377.0" "1489.6" "1239.6" "1455.2" "1443.5" "1269.9" "1413.2" "1415.2" "1268.3" "1317.7" "" "" "" "" "" "" "" "" "" "" "1377.0" "1260.2" "783.8" "1061.0" "1182.6" "986.2" "1089.3" "1216.8" "990.0" "1184.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "107.201" "18" "15" "20" "15" "968" "105.3" "5.40" "78.91" "15" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; Activation of NF-kappaB in B cells; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "151" "0" "1.005" "0.837" "0.970" "0.964" "0.875" "0.989" "1.007" "0.873" "0.948" "1203.6" "1209.8" "1007.2" "1167.1" "1160.5" "1053.0" "1190.7" "1211.9" "1050.6" "1140.9" "" "" "" "" "" "" "" "" "" "" "1203.6" "1023.5" "636.9" "851.0" "950.8" "817.7" "917.9" "1042.0" "820.1" "1025.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9009655612245832545" "False" "High" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "0.000" "False" "106.594" "9" "21" "34" "12" "2542" "271.4" "5.57" "112.04" "21" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf09379, Pf16511, Pf21692" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "Focal adhesion" "" "1" "0" "1.002" "0.944" "1.064" "1.044" "1.050" "1.071" "1.082" "0.999" "1.013" "414.8" "415.5" "391.4" "441.4" "433.0" "435.6" "444.3" "448.6" "414.5" "420.0" "" "" "" "" "" "" "" "" "" "" "414.8" "351.5" "247.5" "321.9" "354.8" "338.3" "342.5" "385.7" "323.5" "377.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "105.729" "36" "13" "41" "13" "475" "52.8" "5.97" "142.67" "13" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "" "Glutathione synthesis and recycling; Paracetamol ADME" "2" "0" "0.985" "1.123" "0.976" "0.979" "1.092" "0.994" "1.008" "1.085" "1.070" "2669.3" "2628.0" "2996.8" "2605.4" "2612.6" "2914.3" "2653.3" "2690.0" "2896.2" "2855.3" "" "" "" "" "" "" "" "" "" "" "2669.3" "2223.3" "1894.9" "1899.7" "2140.6" "2263.2" "2045.3" "2312.8" "2260.7" "2567.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "105.354" "51" "15" "35" "15" "333" "38.4" "5.80" "134.21" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "16" "0" "1.018" "0.957" "0.983" "1.029" "0.990" "0.998" "1.014" "0.941" "0.978" "3327.8" "3389.0" "3186.1" "3269.8" "3423.5" "3294.0" "3322.7" "3373.5" "3132.8" "3253.4" "" "" "" "" "" "" "" "" "" "" "3327.8" "2867.2" "2014.6" "2384.2" "2804.9" "2558.1" "2561.2" "2900.5" "2445.3" "2925.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236879561052220613" "False" "High" "IsMasterProtein" "Q9NX02" "NACHT, LRR and PYD domains-containing protein 2 OS=Homo sapiens OX=9606 GN=NLRP2 PE=1 SV=1" "0.000" "False" "105.313" "21" "23" "37" "23" "1062" "120.4" "6.07" "118.81" "23" "stress response;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02758, Pf05729, Pf13516, Pf17776, Pf17779" "55655" "ENSG00000022556; ENSG00000273992; ENSG00000274638; ENSG00000275082; ENSG00000275399; ENSG00000275796; ENSG00000275843; ENSG00000278682; ENSG00000278789" "NLRP2" "B4DZL7; hsa:55655; I3L0G4; Q53FL5; Q59G09; Q8IXT0; Q9BVN5; Q9H6G6; Q9HAV9; Q9NWK3; Q9NX02" "Nucleotide-binding oligomerization domain (NOD) pathway" "" "1" "0" "1.045" "0.800" "1.053" "1.047" "0.805" "1.017" "1.040" "0.784" "0.950" "1690.1" "1766.7" "1352.7" "1779.5" "1769.2" "1360.7" "1719.4" "1757.8" "1325.6" "1606.3" "" "" "" "" "" "" "" "" "" "" "1690.1" "1494.6" "855.3" "1297.5" "1449.5" "1056.7" "1325.3" "1511.3" "1034.7" "1444.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "104.982" "36" "16" "30" "14" "514" "55.8" "6.90" "109.40" "16" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Rett syndrome" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "5" "1" "0.983" "0.835" "1.002" "0.993" "0.836" "0.976" "1.009" "0.818" "0.977" "1395.0" "1371.0" "1165.1" "1397.5" "1385.2" "1166.0" "1361.2" "1408.1" "1141.5" "1363.4" "" "" "" "" "" "" "" "" "" "" "1395.0" "1159.9" "736.7" "1018.9" "1134.9" "905.5" "1049.3" "1210.7" "891.0" "1225.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "104.972" "30" "13" "51" "13" "450" "50.7" "7.06" "155.84" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Negative regulation of FLT3; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; GAB1 signalosome; Integrin signaling; RHOH GTPase cycle" "18" "0" "1.018" "0.901" "0.976" "1.022" "0.882" "0.956" "1.004" "0.875" "1.008" "4095.7" "4170.5" "3691.7" "3999.1" "4186.7" "3613.2" "3915.7" "4113.1" "3584.9" "4126.9" "" "" "" "" "" "" "" "" "" "" "4095.7" "3528.4" "2334.3" "2915.9" "3430.2" "2805.9" "3018.4" "3536.4" "2798.3" "3710.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "104.497" "23" "17" "38" "17" "795" "90.9" "7.46" "111.19" "17" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.030" "1.072" "0.969" "1.016" "1.070" "0.993" "0.997" "1.043" "1.049" "1857.9" "1913.7" "1992.4" "1800.3" "1888.2" "1988.2" "1845.7" "1851.6" "1937.1" "1949.5" "" "" "" "" "" "" "" "" "" "" "1857.9" "1619.1" "1259.8" "1312.6" "1547.0" "1544.0" "1422.8" "1592.0" "1512.0" "1752.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "104.262" "31" "20" "29" "20" "808" "89.2" "4.65" "103.75" "20" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "5" "0" "0.939" "0.996" "1.000" "1.079" "1.022" "1.205" "0.995" "0.954" "1.034" "897.6" "843.0" "894.2" "897.4" "968.6" "917.1" "1081.8" "893.4" "856.0" "927.8" "" "" "" "" "" "" "" "" "" "" "897.6" "713.2" "565.4" "654.3" "793.6" "712.2" "833.9" "768.2" "668.1" "834.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "104.236" "32" "17" "38" "17" "606" "66.2" "6.65" "129.06" "17" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Hypertrophy model" "Platelet degranulation" "2" "0" "0.961" "1.043" "0.930" "0.960" "1.028" "0.925" "0.982" "1.041" "1.014" "2526.1" "2428.8" "2635.1" "2348.7" "2424.5" "2598.0" "2337.1" "2480.1" "2629.7" "2561.6" "" "" "" "" "" "" "" "" "" "" "2526.1" "2054.8" "1666.2" "1712.6" "1986.4" "2017.6" "1801.5" "2132.4" "2052.7" "2303.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "104.217" "31" "16" "35" "9" "623" "69.6" "8.59" "126.65" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "0" "1.038" "1.125" "0.964" "1.022" "1.175" "0.932" "1.011" "1.101" "1.042" "1083.3" "1124.4" "1218.7" "1043.9" "1106.8" "1272.7" "1009.7" "1095.2" "1192.3" "1128.3" "" "" "" "" "" "" "" "" "" "" "1083.3" "951.2" "770.6" "761.2" "906.8" "988.3" "778.3" "941.6" "930.7" "1014.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "103.724" "31" "23" "39" "23" "798" "88.8" "6.25" "121.24" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "0.990" "0.832" "1.007" "0.989" "0.798" "1.011" "1.018" "0.813" "0.924" "2717.5" "2689.1" "2261.7" "2737.3" "2686.9" "2169.5" "2747.6" "2767.4" "2209.4" "2511.9" "" "" "" "" "" "" "" "" "" "" "2717.5" "2275.0" "1430.1" "1995.9" "2201.4" "1684.8" "2118.0" "2379.4" "1724.6" "2258.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "103.573" "57" "11" "82" "6" "246" "28.1" "4.83" "248.11" "11" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "33" "0" "0.980" "1.044" "0.952" "1.030" "1.073" "0.966" "0.990" "1.053" "1.021" "1406.4" "1378.8" "1468.8" "1338.5" "1447.9" "1508.7" "1358.2" "1392.1" "1480.2" "1436.0" "" "" "" "" "" "" "" "" "" "" "1406.4" "1166.5" "928.7" "975.9" "1186.3" "1171.6" "1047.0" "1196.9" "1155.4" "1291.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "103.284" "17" "21" "30" "14" "1214" "132.8" "5.69" "97.03" "21" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "7" "0" "1.001" "0.960" "0.996" "1.072" "0.976" "1.025" "1.034" "0.937" "1.015" "1248.2" "1249.7" "1198.2" "1242.9" "1337.7" "1217.9" "1279.9" "1291.0" "1169.8" "1266.5" "" "" "" "" "" "" "" "" "" "" "1248.2" "1057.3" "757.6" "906.3" "1096.0" "945.8" "986.6" "1110.0" "913.1" "1138.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "102.938" "33" "21" "48" "21" "660" "75.3" "6.68" "149.26" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.991" "1.015" "1.017" "1.030" "1.012" "1.025" "1.016" "0.987" "1.005" "2884.4" "2858.6" "2926.9" "2934.7" "2970.1" "2918.6" "2956.4" "2929.7" "2848.3" "2897.7" "" "" "" "" "" "" "" "" "" "" "2884.4" "2418.4" "1850.7" "2139.8" "2433.4" "2266.5" "2278.9" "2518.9" "2223.3" "2605.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "102.422" "8" "23" "33" "22" "2896" "316.7" "9.13" "105.41" "23" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "VEGFA-VEGFR2 signaling" "" "1" "1" "0.971" "1.081" "0.962" "1.005" "1.103" "1.046" "1.013" "1.079" "1.017" "1934.8" "1878.5" "2091.7" "1860.6" "1944.7" "2133.9" "2024.6" "1959.4" "2088.5" "1967.8" "" "" "" "" "" "" "" "" "" "" "1934.8" "1589.3" "1322.6" "1356.6" "1593.3" "1657.2" "1560.6" "1684.7" "1630.2" "1769.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "102.412" "45" "14" "34" "14" "456" "50.2" "6.42" "116.48" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "Formation of the beta-catenin:TCF transactivating complex; Ub-specific processing proteases; UCH proteinases; Deposition of new CENPA-containing nucleosomes at the centromere; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "9" "0" "0.999" "0.975" "0.991" "0.992" "0.957" "1.010" "1.024" "0.895" "0.959" "1515.0" "1512.8" "1477.3" "1501.0" "1503.6" "1449.6" "1529.7" "1550.8" "1355.8" "1452.3" "" "" "" "" "" "" "" "" "" "" "1515.0" "1279.9" "934.1" "1094.5" "1231.9" "1125.7" "1179.1" "1333.4" "1058.3" "1305.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "102.089" "42" "14" "45" "14" "418" "47.3" "5.88" "146.49" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Physico-chemical features and toxicity-associated pathways" "EPHB-mediated forward signaling; FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis" "6" "0" "1.040" "1.077" "0.998" "1.010" "1.067" "0.954" "1.044" "1.066" "1.106" "3136.9" "3262.5" "3379.7" "3130.5" "3166.7" "3346.0" "2992.7" "3274.1" "3343.1" "3470.7" "" "" "" "" "" "" "" "" "" "" "3136.9" "2760.1" "2137.0" "2282.6" "2594.5" "2598.5" "2306.9" "2815.0" "2609.5" "3120.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "101.654" "31" "13" "57" "12" "432" "47.7" "6.34" "172.16" "13" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "11" "1" "1.006" "1.112" "1.006" "0.984" "1.076" "0.970" "0.996" "1.042" "1.043" "3618.8" "3640.3" "4025.4" "3640.2" "3561.1" "3895.2" "3509.5" "3604.4" "3769.2" "3775.8" "" "" "" "" "" "" "" "" "" "" "3618.8" "3079.8" "2545.3" "2654.2" "2917.6" "3025.0" "2705.3" "3099.0" "2942.1" "3394.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "101.575" "39" "20" "36" "20" "528" "59.1" "7.05" "117.65" "20" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Nephrotic syndrome" "Cytosolic tRNA aminoacylation" "2" "0" "0.976" "0.870" "0.931" "0.970" "0.831" "0.911" "1.002" "0.850" "0.954" "2436.5" "2377.5" "2119.0" "2268.2" "2363.8" "2025.0" "2220.1" "2441.8" "2070.9" "2325.3" "" "" "" "" "" "" "" "" "" "" "2436.5" "2011.4" "1339.8" "1653.8" "1936.6" "1572.6" "1711.3" "2099.5" "1616.4" "2090.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "101.375" "20" "19" "30" "19" "1031" "117.3" "9.29" "104.06" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "" "mRNA Splicing - Major Pathway" "1" "0" "0.994" "1.030" "0.987" "0.969" "1.009" "1.059" "1.062" "0.922" "1.046" "1289.6" "1281.5" "1328.5" "1272.5" "1249.9" "1301.0" "1365.9" "1369.3" "1189.7" "1348.5" "" "" "" "" "" "" "" "" "" "" "1289.6" "1084.2" "840.0" "927.9" "1024.0" "1010.3" "1052.9" "1177.3" "928.6" "1212.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "101.298" "49" "8" "93" "8" "210" "23.3" "5.64" "322.43" "8" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "11" "0" "1.016" "1.065" "1.033" "0.990" "1.009" "0.968" "1.005" "1.036" "1.094" "3441.0" "3496.3" "3664.9" "3553.4" "3408.0" "3473.7" "3330.9" "3459.8" "3563.6" "3764.8" "" "" "" "" "" "" "" "" "" "" "3441.0" "2958.0" "2317.4" "2590.9" "2792.2" "2697.6" "2567.6" "2974.7" "2781.6" "3384.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "101.295" "33" "14" "37" "14" "456" "52.9" "7.65" "118.01" "14" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.049" "0.973" "1.019" "1.015" "0.952" "1.001" "1.030" "0.934" "1.006" "1913.1" "2007.6" "1860.7" "1949.2" "1940.8" "1821.2" "1915.4" "1969.9" "1786.3" "1924.9" "" "" "" "" "" "" "" "" "" "" "1913.1" "1698.4" "1176.5" "1421.2" "1590.1" "1414.3" "1476.4" "1693.7" "1394.3" "1730.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "101.294" "22" "17" "29" "17" "864" "94.2" "5.11" "104.60" "17" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "4" "0" "0.995" "1.038" "1.009" "1.054" "1.052" "1.029" "1.017" "1.045" "1.028" "1611.3" "1603.0" "1672.8" "1625.7" "1698.8" "1695.6" "1657.7" "1638.0" "1683.0" "1656.7" "" "" "" "" "" "" "" "" "" "" "1611.3" "1356.2" "1057.7" "1185.4" "1391.9" "1316.8" "1277.8" "1408.4" "1313.7" "1489.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "100.481" "28" "16" "50" "16" "597" "68.0" "6.35" "163.02" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.005" "1.022" "1.070" "1.022" "0.954" "1.038" "1.004" "0.980" "0.981" "1971.4" "1981.7" "2015.2" "2110.3" "2015.7" "1880.1" "2046.3" "1979.4" "1932.0" "1933.3" "" "" "" "" "" "" "" "" "" "" "1971.4" "1676.6" "1274.2" "1538.7" "1651.5" "1460.1" "1577.4" "1701.9" "1508.0" "1738.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "100.439" "8" "22" "28" "22" "2799" "309.2" "5.85" "91.78" "22" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "Mesodermal commitment pathway" "" "1" "0" "1.027" "0.842" "1.048" "1.065" "0.858" "1.077" "1.094" "0.831" "0.996" "1253.6" "1287.1" "1055.3" "1313.3" "1334.9" "1075.6" "1349.6" "1371.9" "1041.7" "1249.2" "" "" "" "" "" "" "" "" "" "" "1253.6" "1088.9" "667.2" "957.6" "1093.7" "835.3" "1040.3" "1179.5" "813.1" "1123.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "100.392" "58" "13" "79" "9" "247" "28.3" "4.89" "214.91" "13" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "22" "0" "0.998" "1.070" "0.963" "0.997" "1.084" "0.993" "1.039" "1.073" "1.063" "2355.5" "2351.7" "2520.4" "2267.4" "2348.5" "2552.7" "2338.9" "2448.1" "2526.7" "2504.4" "" "" "" "" "" "" "" "" "" "" "2355.5" "1989.6" "1593.6" "1653.2" "1924.1" "1982.4" "1802.9" "2104.9" "1972.2" "2251.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "100.251" "40" "13" "84" "12" "332" "36.7" "8.27" "282.26" "13" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "Pyruvate metabolism" "20" "1" "0.979" "1.044" "0.987" "0.957" "1.079" "0.946" "0.963" "1.033" "1.059" "5775.4" "5655.1" "6029.1" "5698.5" "5526.1" "6231.1" "5462.2" "5563.2" "5968.0" "6116.6" "" "" "" "" "" "" "" "" "" "" "5775.4" "4784.3" "3812.2" "4155.0" "4527.6" "4838.9" "4210.5" "4783.2" "4658.4" "5499.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "100.049" "22" "12" "41" "12" "611" "69.1" "5.73" "142.80" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "16" "0" "0.958" "1.130" "1.027" "1.019" "1.228" "1.207" "0.987" "1.141" "1.028" "1913.0" "1832.5" "2162.5" "1964.1" "1949.0" "2350.0" "2309.7" "1887.8" "2182.5" "1967.3" "" "" "" "" "" "" "" "" "" "" "1913.0" "1550.3" "1367.3" "1432.1" "1596.8" "1824.9" "1780.4" "1623.1" "1703.5" "1768.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "100.002" "33" "14" "40" "14" "430" "47.5" "9.01" "127.98" "14" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "11" "0" "0.974" "1.096" "0.919" "0.950" "1.025" "0.907" "0.978" "1.039" "0.991" "2132.0" "2077.0" "2335.8" "1958.5" "2025.6" "2184.7" "1933.7" "2085.9" "2214.2" "2112.0" "" "" "" "" "" "" "" "" "" "" "2132.0" "1757.2" "1477.0" "1428.0" "1659.6" "1696.6" "1490.6" "1793.4" "1728.3" "1898.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "99.968" "16" "17" "26" "17" "1270" "140.9" "6.84" "96.47" "17" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "MECP2 and associated Rett syndrome; mRNA processing" "PKR-mediated signaling; mRNA Splicing - Major Pathway; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "6" "0" "1.059" "1.566" "1.064" "1.108" "1.650" "1.078" "1.149" "1.675" "1.251" "887.6" "939.7" "1390.2" "944.0" "983.2" "1464.2" "957.1" "1019.8" "1486.8" "1110.7" "" "" "" "" "" "" "" "" "" "" "887.6" "795.0" "879.0" "688.3" "805.6" "1137.1" "737.8" "876.9" "1160.5" "998.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "99.847" "43" "14" "48" "14" "331" "38.2" "5.38" "166.28" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Ciliary landscape; PAFAH1B1 copy number variation" "RND2 GTPase cycle; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.000" "1.055" "1.012" "0.983" "1.012" "1.012" "0.997" "0.977" "0.955" "3622.3" "3622.2" "3821.3" "3663.9" "3560.4" "3667.0" "3667.0" "3612.1" "3538.6" "3459.6" "" "" "" "" "" "" "" "" "" "" "3622.3" "3064.5" "2416.2" "2671.6" "2917.1" "2847.8" "2826.7" "3105.7" "2762.1" "3110.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "99.282" "46" "13" "29" "13" "370" "40.5" "5.10" "114.36" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "Alstrom syndrome" "RHOH GTPase cycle" "2" "0" "0.992" "1.108" "1.041" "1.043" "1.127" "1.036" "1.008" "1.108" "1.054" "1553.2" "1541.1" "1721.2" "1617.5" "1620.0" "1750.1" "1609.5" "1565.7" "1720.9" "1636.4" "" "" "" "" "" "" "" "" "" "" "1553.2" "1303.8" "1088.3" "1179.4" "1327.3" "1359.1" "1240.7" "1346.2" "1343.3" "1471.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "99.057" "14" "29" "32" "26" "2099" "238.4" "6.87" "102.73" "29" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "" "CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "4" "3" "1.004" "0.913" "0.989" "0.967" "0.951" "0.989" "0.980" "0.929" "0.968" "1795.9" "1802.7" "1639.4" "1775.4" "1736.6" "1707.7" "1776.0" "1759.4" "1667.6" "1738.7" "" "" "" "" "" "" "" "" "" "" "1795.9" "1525.2" "1036.6" "1294.5" "1422.8" "1326.2" "1369.0" "1512.7" "1301.6" "1563.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "98.738" "11" "25" "32" "25" "2554" "290.3" "5.80" "100.22" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ciliopathies; Bardet-Biedl syndrome" "Ub-specific processing proteases; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "0.986" "0.977" "1.061" "1.026" "0.964" "1.023" "0.997" "0.936" "1.045" "1361.7" "1342.9" "1330.1" "1444.3" "1396.4" "1313.1" "1392.7" "1357.1" "1273.9" "1423.2" "" "" "" "" "" "" "" "" "" "" "1361.7" "1136.1" "841.0" "1053.1" "1144.1" "1019.7" "1073.6" "1166.9" "994.4" "1279.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "98.603" "68" "12" "65" "11" "199" "22.4" "8.25" "197.12" "12" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "" "Platelet degranulation" "1" "1" "0.995" "1.040" "1.088" "0.977" "1.094" "1.070" "0.994" "1.100" "1.022" "2869.7" "2855.9" "2984.3" "3123.1" "2804.8" "3138.6" "3071.1" "2852.4" "3156.4" "2932.4" "" "" "" "" "" "" "" "" "" "" "2869.7" "2416.1" "1887.0" "2277.2" "2298.0" "2437.4" "2367.3" "2452.5" "2463.8" "2636.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "98.305" "16" "18" "25" "18" "1269" "144.7" "6.05" "88.89" "18" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.069" "1.056" "1.026" "1.052" "0.969" "1.012" "1.045" "1.029" "1.051" "1500.1" "1602.9" "1583.9" "1539.0" "1577.8" "1453.6" "1518.0" "1567.4" "1543.6" "1576.9" "" "" "" "" "" "" "" "" "" "" "1500.1" "1356.1" "1001.5" "1122.2" "1292.7" "1128.9" "1170.2" "1347.7" "1204.9" "1417.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "98.213" "35" "11" "48" "8" "364" "39.4" "6.87" "178.45" "11" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "6" "0" "1.044" "1.155" "1.095" "1.076" "1.124" "1.064" "1.037" "1.154" "1.160" "1815.2" "1894.5" "2096.3" "1988.3" "1953.9" "2039.9" "1931.0" "1881.8" "2095.4" "2105.6" "" "" "" "" "" "" "" "" "" "" "1815.2" "1602.8" "1325.5" "1449.7" "1600.9" "1584.2" "1488.5" "1617.9" "1635.6" "1893.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "98.153" "26" "18" "32" "18" "719" "81.3" "6.46" "113.35" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.098" "1.021" "1.063" "1.073" "0.986" "1.056" "1.108" "0.966" "1.025" "1998.7" "2193.7" "2041.4" "2124.5" "2145.4" "1970.9" "2110.3" "2215.5" "1930.7" "2049.4" "" "" "" "" "" "" "" "" "" "" "1998.7" "1856.0" "1290.8" "1549.1" "1757.7" "1530.6" "1626.7" "1904.9" "1507.0" "1842.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "98.018" "34" "13" "34" "13" "437" "49.0" "5.71" "111.88" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "6" "0" "0.970" "1.080" "0.964" "0.981" "0.984" "0.959" "0.977" "0.994" "1.013" "2211.2" "2144.0" "2387.8" "2132.0" "2170.0" "2176.9" "2119.8" "2160.3" "2198.2" "2240.3" "" "" "" "" "" "" "" "" "" "" "2211.2" "1813.9" "1509.8" "1554.5" "1777.9" "1690.5" "1634.1" "1857.4" "1715.8" "2014.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "97.965" "17" "22" "30" "22" "1360" "152.7" "6.90" "87.03" "22" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "8" "0" "1.079" "0.821" "1.012" "1.068" "0.849" "1.033" "0.969" "0.796" "1.001" "1655.1" "1785.4" "1358.3" "1675.6" "1768.3" "1404.5" "1709.3" "1603.4" "1318.0" "1656.1" "" "" "" "" "" "" "" "" "" "" "1655.1" "1510.5" "858.9" "1221.7" "1448.8" "1090.7" "1317.6" "1378.6" "1028.8" "1488.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "97.957" "24" "17" "35" "17" "900" "101.1" "6.16" "115.18" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.015" "0.896" "1.025" "0.999" "0.866" "0.935" "0.972" "0.869" "0.980" "1759.8" "1786.7" "1575.9" "1803.2" "1758.4" "1523.2" "1644.7" "1710.2" "1529.3" "1724.8" "" "" "" "" "" "" "" "" "" "" "1759.8" "1511.6" "996.5" "1314.8" "1440.6" "1182.9" "1267.8" "1470.4" "1193.7" "1550.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "97.877" "21" "20" "36" "20" "1052" "117.9" "6.14" "117.18" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.005" "0.939" "1.000" "0.973" "0.965" "0.931" "1.001" "0.973" "1.004" "2030.4" "2040.5" "1906.3" "2029.8" "1974.7" "1958.6" "1889.4" "2032.0" "1975.4" "2038.9" "" "" "" "" "" "" "" "" "" "" "2030.4" "1726.3" "1205.3" "1480.0" "1617.9" "1521.0" "1456.4" "1747.1" "1541.9" "1833.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "97.605" "21" "25" "27" "22" "1354" "158.1" "5.90" "84.70" "25" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "RND3 GTPase cycle; RHOBTB1 GTPase cycle; Neutrophil degranulation; VEGFA-VEGFR2 Pathway; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "35" "0" "1.012" "1.041" "1.049" "1.028" "1.028" "1.065" "1.075" "1.005" "1.052" "1120.9" "1134.4" "1167.1" "1176.1" "1151.9" "1152.1" "1193.2" "1204.5" "1126.8" "1179.5" "" "" "" "" "" "" "" "" "" "" "1120.9" "959.8" "737.9" "857.6" "943.7" "894.7" "919.8" "1035.6" "879.5" "1060.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "97.574" "32" "19" "50" "15" "644" "67.5" "7.61" "165.35" "19" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "2" "1.038" "1.045" "1.017" "1.044" "1.044" "0.976" "0.997" "1.071" "1.070" "2996.3" "3109.6" "3130.9" "3047.5" "3129.0" "3127.8" "2924.3" "2987.8" "3207.6" "3207.0" "" "" "" "" "" "" "" "" "" "" "2996.3" "2630.8" "1979.7" "2222.0" "2563.6" "2429.0" "2254.2" "2568.9" "2503.8" "2883.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "97.182" "26" "12" "37" "12" "528" "59.4" "4.41" "136.20" "12" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "7" "0" "1.042" "1.086" "1.116" "1.102" "1.058" "1.058" "1.052" "1.067" "1.073" "2051.6" "2138.3" "2228.2" "2289.6" "2259.9" "2170.1" "2171.0" "2158.0" "2188.2" "2200.7" "" "" "" "" "" "" "" "" "" "" "2051.6" "1809.0" "1408.9" "1669.5" "1851.6" "1685.3" "1673.5" "1855.4" "1708.0" "1978.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "96.774" "36" "17" "48" "17" "437" "50.1" "6.67" "160.27" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Translation factors" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "3" "0" "1.021" "1.129" "1.034" "1.006" "1.059" "0.988" "1.027" "1.028" "1.045" "2774.0" "2832.3" "3130.6" "2869.0" "2790.6" "2938.5" "2740.7" "2849.7" "2851.0" "2897.8" "" "" "" "" "" "" "" "" "" "" "2774.0" "2396.2" "1979.5" "2091.9" "2286.4" "2282.0" "2112.6" "2450.2" "2225.4" "2605.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "96.673" "31" "16" "42" "16" "553" "59.7" "9.13" "148.24" "16" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "7" "0" "1.080" "1.253" "1.048" "1.112" "1.177" "1.112" "1.109" "1.208" "1.102" "1355.2" "1463.4" "1697.5" "1420.1" "1506.5" "1595.4" "1506.7" "1502.7" "1636.7" "1492.8" "" "" "" "" "" "" "" "" "" "" "1355.2" "1238.0" "1073.3" "1035.4" "1234.3" "1238.9" "1161.4" "1292.0" "1277.5" "1342.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "96.505" "58" "16" "46" "15" "320" "35.9" "5.05" "153.50" "16" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "Platelet degranulation" "4" "1" "0.958" "1.014" "0.924" "0.917" "0.962" "0.905" "0.934" "1.043" "0.990" "2598.6" "2488.9" "2635.0" "2400.3" "2383.7" "2498.6" "2352.6" "2427.7" "2711.6" "2572.9" "" "" "" "" "" "" "" "" "" "" "2598.6" "2105.7" "1666.1" "1750.2" "1953.0" "1940.4" "1813.5" "2087.4" "2116.6" "2313.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "96.320" "24" "16" "30" "16" "763" "82.9" "9.04" "113.83" "16" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "13" "0" "0.995" "0.967" "0.939" "0.995" "0.930" "0.990" "0.995" "0.931" "0.975" "1770.8" "1761.4" "1711.7" "1661.9" "1762.3" "1647.7" "1752.2" "1761.2" "1648.1" "1726.6" "" "" "" "" "" "" "" "" "" "" "1770.8" "1490.2" "1082.3" "1211.8" "1443.9" "1279.6" "1350.7" "1514.3" "1286.5" "1552.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "95.704" "22" "13" "27" "13" "694" "75.4" "7.66" "98.00" "13" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.011" "1.162" "1.055" "1.131" "1.262" "1.071" "1.071" "1.173" "1.104" "1426.9" "1442.7" "1657.4" "1506.1" "1614.4" "1800.3" "1528.0" "1527.7" "1673.2" "1574.8" "" "" "" "" "" "" "" "" "" "" "1426.9" "1220.5" "1048.0" "1098.1" "1322.7" "1398.1" "1177.8" "1313.6" "1306.0" "1415.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "95.556" "16" "16" "28" "16" "1081" "118.6" "4.96" "98.80" "16" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.011" "0.802" "0.930" "0.976" "0.810" "0.955" "0.993" "0.879" "1.004" "1410.8" "1425.7" "1131.8" "1312.2" "1376.9" "1143.0" "1347.9" "1401.5" "1240.4" "1416.5" "" "" "" "" "" "" "" "" "" "" "1410.8" "1206.2" "715.6" "956.8" "1128.1" "887.6" "1039.0" "1205.0" "968.2" "1273.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "95.372" "20" "18" "27" "18" "961" "104.3" "5.27" "91.46" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "1.034" "0.911" "1.026" "1.034" "0.935" "1.027" "1.013" "0.925" "0.986" "1244.4" "1286.8" "1133.8" "1276.4" "1286.2" "1163.8" "1278.1" "1260.0" "1151.1" "1227.3" "" "" "" "" "" "" "" "" "" "" "1244.4" "1088.7" "716.9" "930.7" "1053.8" "903.8" "985.2" "1083.4" "898.5" "1103.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "95.134" "25" "14" "35" "14" "640" "71.2" "5.29" "114.34" "14" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "1.006" "1.120" "1.013" "1.020" "1.055" "1.001" "1.005" "1.125" "1.062" "1823.5" "1833.9" "2041.8" "1847.5" "1860.2" "1923.8" "1826.1" "1832.0" "2050.8" "1937.0" "" "" "" "" "" "" "" "" "" "" "1823.5" "1551.5" "1291.1" "1347.1" "1524.1" "1494.0" "1407.6" "1575.2" "1600.8" "1741.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "95.016" "58" "14" "33" "14" "246" "27.4" "6.76" "105.79" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.962" "1.051" "0.952" "0.868" "0.981" "0.898" "0.946" "0.993" "1.052" "2027.6" "1950.8" "2131.2" "1930.3" "1760.7" "1988.1" "1820.1" "1917.1" "2014.2" "2132.5" "" "" "" "" "" "" "" "" "" "" "2027.6" "1650.4" "1347.6" "1407.5" "1442.6" "1543.9" "1403.0" "1648.3" "1572.2" "1917.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "95.005" "57" "11" "94" "6" "245" "27.7" "4.78" "263.28" "11" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "19" "0" "1.011" "1.010" "1.032" "1.034" "1.050" "1.011" "1.060" "1.021" "1.107" "1000.1" "1011.1" "1009.7" "1031.9" "1034.5" "1049.9" "1011.6" "1060.3" "1021.0" "1106.8" "" "" "" "" "" "" "" "" "" "" "1000.1" "855.4" "638.4" "752.4" "847.6" "815.3" "779.8" "911.7" "797.0" "995.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "94.854" "32" "17" "43" "17" "531" "58.0" "6.68" "134.11" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "7" "0" "1.029" "1.114" "1.026" "1.035" "1.053" "0.999" "1.032" "1.022" "1.084" "1789.1" "1840.7" "1992.8" "1835.0" "1852.0" "1884.1" "1788.1" "1846.5" "1828.8" "1940.1" "" "" "" "" "" "" "" "" "" "" "1789.1" "1557.3" "1260.0" "1338.0" "1517.4" "1463.2" "1378.3" "1587.6" "1427.5" "1744.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "94.618" "29" "12" "30" "6" "487" "55.6" "5.07" "97.41" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "Signaling by Hippo" "4" "4" "1.066" "0.846" "0.996" "1.030" "0.889" "0.989" "0.988" "0.839" "0.887" "1362.5" "1452.5" "1152.9" "1357.1" "1402.8" "1211.8" "1347.9" "1345.8" "1142.5" "1208.5" "" "" "" "" "" "" "" "" "" "" "1362.5" "1228.9" "729.0" "989.5" "1149.3" "941.1" "1039.0" "1157.1" "891.8" "1086.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "94.291" "23" "12" "44" "12" "584" "65.4" "7.61" "156.57" "12" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "TCA cycle in senescence" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "3" "0" "1.033" "1.093" "0.961" "1.008" "1.063" "0.951" "1.009" "1.071" "1.038" "2756.7" "2846.9" "3014.1" "2649.6" "2778.7" "2931.7" "2620.4" "2781.9" "2952.7" "2862.5" "" "" "" "" "" "" "" "" "" "" "2756.7" "2408.5" "1905.8" "1932.0" "2276.6" "2276.7" "2019.9" "2391.8" "2304.8" "2573.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "94.170" "12" "23" "27" "23" "1970" "217.0" "7.37" "83.44" "23" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "1.033" "1.041" "1.024" "1.063" "1.003" "1.013" "1.046" "0.960" "1.033" "1039.7" "1074.6" "1081.9" "1064.3" "1105.4" "1042.9" "1053.7" "1087.5" "997.8" "1074.0" "" "" "" "" "" "" "" "" "" "" "1039.7" "909.1" "684.1" "776.0" "905.6" "809.9" "812.3" "935.0" "778.9" "965.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "94.010" "20" "18" "32" "18" "981" "108.8" "6.40" "103.81" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "Non-small cell lung cancer" "Signaling by ALK fusions and activated point mutants; EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs" "4" "0" "0.966" "0.952" "0.972" "1.002" "0.950" "0.980" "1.016" "0.909" "0.994" "1618.4" "1563.4" "1541.1" "1573.0" "1622.2" "1537.2" "1586.2" "1643.7" "1471.1" "1608.1" "" "" "" "" "" "" "" "" "" "" "1618.4" "1322.7" "974.5" "1146.9" "1329.1" "1193.7" "1222.7" "1413.2" "1148.3" "1445.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "93.529" "29" "9" "46" "8" "355" "38.4" "7.81" "166.00" "9" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "1" "0.993" "1.101" "0.964" "1.003" "1.071" "1.026" "0.938" "1.063" "1.114" "2499.3" "2481.0" "2750.9" "2408.5" "2507.5" "2676.4" "2565.1" "2343.5" "2657.0" "2784.4" "" "" "" "" "" "" "" "" "" "" "2499.3" "2099.0" "1739.4" "1756.2" "2054.4" "2078.4" "1977.3" "2014.9" "2073.9" "2503.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "93.434" "33" "19" "35" "19" "589" "66.1" "6.84" "111.63" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "1.008" "0.957" "0.963" "0.987" "0.973" "0.925" "0.952" "0.959" "0.958" "2130.6" "2147.9" "2039.2" "2051.8" "2103.9" "2072.2" "1971.7" "2028.0" "2043.2" "2040.6" "" "" "" "" "" "" "" "" "" "" "2130.6" "1817.1" "1289.4" "1496.1" "1723.7" "1609.3" "1519.9" "1743.7" "1594.8" "1834.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "93.361" "42" "9" "32" "8" "281" "31.1" "5.01" "135.50" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Translation factors" "Eukaryotic Translation Elongation" "2" "1" "0.964" "1.000" "0.994" "0.963" "0.957" "1.018" "0.987" "0.967" "0.993" "2374.2" "2287.9" "2374.4" "2359.4" "2285.9" "2272.7" "2417.1" "2342.6" "2295.3" "2358.7" "" "" "" "" "" "" "" "" "" "" "2374.2" "1935.6" "1501.4" "1720.3" "1872.9" "1764.9" "1863.2" "2014.2" "1791.6" "2120.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "93.357" "27" "11" "40" "10" "452" "50.9" "8.69" "139.13" "11" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "7" "1" "1.055" "1.042" "1.039" "0.990" "1.031" "0.977" "0.998" "1.049" "1.090" "1859.7" "1961.2" "1937.4" "1932.6" "1841.3" "1918.0" "1817.4" "1856.2" "1950.8" "2026.6" "" "" "" "" "" "" "" "" "" "" "1859.7" "1659.2" "1225.0" "1409.1" "1508.6" "1489.5" "1400.9" "1596.0" "1522.7" "1822.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "93.348" "20" "19" "24" "14" "913" "103.9" "7.37" "84.18" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "5" "0.958" "0.949" "0.878" "0.907" "0.869" "0.861" "0.899" "0.906" "0.948" "1956.9" "1874.5" "1857.0" "1718.6" "1775.1" "1699.6" "1684.5" "1759.7" "1772.2" "1854.6" "" "" "" "" "" "" "" "" "" "" "1956.9" "1585.8" "1174.2" "1253.1" "1454.3" "1319.9" "1298.5" "1513.0" "1383.3" "1667.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5793722554403523201" "False" "High" "IsMasterProtein" "Q14764" "Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4" "0.000" "False" "93.287" "20" "16" "22" "16" "893" "99.3" "5.48" "84.77" "16" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01505, Pf11978, Pf17794, Pf17795, Pf17796" "9961" "ENSG00000013364" "MVP" "hsa:9961; Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation" "2" "0" "1.003" "1.148" "1.091" "1.052" "1.145" "1.024" "1.048" "1.159" "1.102" "1102.2" "1106.0" "1265.3" "1202.9" "1159.2" "1261.7" "1128.7" "1155.1" "1277.5" "1214.6" "" "" "" "" "" "" "" "" "" "" "1102.2" "935.7" "800.1" "877.1" "949.8" "979.8" "870.0" "993.1" "997.1" "1092.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "93.208" "33" "12" "45" "12" "425" "47.0" "7.23" "156.74" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "2" "0" "0.986" "0.969" "0.990" "0.934" "0.948" "0.922" "0.956" "0.943" "0.981" "2769.9" "2729.8" "2684.3" "2741.8" "2585.8" "2624.8" "2553.2" "2648.8" "2612.4" "2716.3" "" "" "" "" "" "" "" "" "" "" "2769.9" "2309.5" "1697.3" "1999.2" "2118.5" "2038.3" "1968.1" "2277.5" "2039.2" "2442.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "93.157" "31" "17" "29" "17" "667" "75.9" "6.98" "90.40" "17" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Leukocyte-intrinsic Hippo pathway functions" "Platelet degranulation" "2" "0" "1.074" "0.970" "1.035" "0.992" "0.956" "0.991" "1.060" "1.000" "1.054" "653.1" "701.3" "633.7" "675.7" "648.1" "624.3" "647.5" "692.5" "652.8" "688.2" "" "" "" "" "" "" "" "" "" "" "653.1" "593.3" "400.7" "492.7" "531.0" "484.8" "499.1" "595.5" "509.6" "618.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "92.901" "27" "16" "34" "9" "633" "70.9" "8.13" "120.60" "16" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "6" "1.020" "1.188" "0.918" "0.974" "1.208" "0.956" "1.010" "1.213" "1.064" "2924.4" "2981.9" "3473.3" "2685.1" "2847.8" "3532.7" "2796.7" "2954.7" "3547.4" "3111.5" "" "" "" "" "" "" "" "" "" "" "2924.4" "2522.8" "2196.2" "1957.8" "2333.2" "2743.4" "2155.8" "2540.5" "2768.9" "2797.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "92.785" "49" "12" "44" "8" "356" "37.5" "7.09" "138.93" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "Ferroptosis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "5" "1.005" "0.874" "1.030" "0.982" "0.846" "1.017" "1.008" "0.831" "0.918" "1926.1" "1935.0" "1683.2" "1983.9" "1891.9" "1628.9" "1958.3" "1942.3" "1601.4" "1767.6" "" "" "" "" "" "" "" "" "" "" "1926.1" "1637.1" "1064.3" "1446.6" "1550.0" "1265.0" "1509.5" "1670.0" "1250.0" "1589.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "92.653" "4" "26" "28" "25" "7388" "837.8" "5.39" "81.27" "26" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "0" "0.993" "1.071" "1.018" "0.998" "1.013" "0.982" "1.018" "1.016" "0.997" "1270.6" "1261.5" "1360.4" "1294.0" "1268.0" "1287.1" "1247.4" "1293.0" "1291.5" "1267.2" "" "" "" "" "" "" "" "" "" "" "1270.6" "1067.3" "860.2" "943.5" "1038.9" "999.5" "961.5" "1111.7" "1008.1" "1139.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "92.261" "38" "13" "38" "13" "346" "38.4" "5.30" "139.87" "13" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.986" "1.001" "0.998" "0.983" "0.992" "0.960" "0.967" "0.986" "1.021" "2251.4" "2220.7" "2253.3" "2247.6" "2212.6" "2234.1" "2162.0" "2176.3" "2220.1" "2298.9" "" "" "" "" "" "" "" "" "" "" "2251.4" "1878.7" "1424.8" "1638.9" "1812.8" "1735.0" "1666.6" "1871.2" "1732.9" "2066.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "92.022" "19" "15" "27" "15" "923" "102.8" "5.22" "92.80" "15" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "TAR syndrome" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.989" "0.864" "0.993" "0.988" "0.899" "1.007" "1.046" "0.847" "0.949" "2151.9" "2129.1" "1859.3" "2137.2" "2126.2" "1934.6" "2167.6" "2250.9" "1822.2" "2041.9" "" "" "" "" "" "" "" "" "" "" "2151.9" "1801.2" "1175.6" "1558.4" "1742.0" "1502.4" "1670.9" "1935.3" "1422.4" "1835.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "92.008" "20" "23" "28" "23" "1321" "146.1" "5.15" "87.12" "23" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "" "Myogenesis" "1" "0" "0.995" "0.984" "1.003" "1.104" "1.020" "1.031" "1.053" "0.981" "1.029" "1387.0" "1379.5" "1365.4" "1391.5" "1531.6" "1414.2" "1429.4" "1460.2" "1360.1" "1426.8" "" "" "" "" "" "" "" "" "" "" "1387.0" "1167.1" "863.3" "1014.6" "1254.9" "1098.2" "1101.8" "1255.5" "1061.6" "1282.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "91.926" "13" "17" "26" "17" "1393" "155.9" "5.62" "87.16" "17" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.029" "0.832" "1.058" "1.006" "0.834" "0.993" "1.068" "0.809" "0.949" "1557.0" "1602.7" "1295.3" "1646.7" "1567.1" "1298.6" "1545.9" "1663.1" "1259.6" "1477.0" "" "" "" "" "" "" "" "" "" "" "1557.0" "1355.9" "819.0" "1200.7" "1283.9" "1008.5" "1191.7" "1429.9" "983.2" "1327.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "91.905" "18" "15" "29" "15" "959" "106.4" "6.39" "101.89" "15" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "Mitochondrial protein degradation" "1" "0" "1.036" "1.037" "1.007" "1.034" "1.037" "0.983" "1.055" "1.015" "1.045" "1754.4" "1816.8" "1819.1" "1766.9" "1813.2" "1820.0" "1724.4" "1850.8" "1781.6" "1833.3" "" "" "" "" "" "" "" "" "" "" "1754.4" "1537.1" "1150.2" "1288.3" "1485.6" "1413.4" "1329.3" "1591.3" "1390.6" "1648.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "91.859" "19" "13" "27" "13" "785" "88.2" "9.28" "93.74" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "" "IRF3-mediated induction of type I IFN" "2" "0" "1.112" "0.880" "0.993" "1.150" "0.955" "0.972" "0.977" "0.907" "0.967" "1273.2" "1415.5" "1120.0" "1264.0" "1464.2" "1215.8" "1237.2" "1244.3" "1155.1" "1231.3" "" "" "" "" "" "" "" "" "" "" "1273.2" "1197.5" "708.2" "921.6" "1199.6" "944.2" "953.6" "1069.9" "901.6" "1107.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "91.320" "39" "15" "44" "15" "395" "43.6" "6.48" "146.92" "15" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "Methylation" "5" "0" "0.977" "0.983" "0.916" "0.926" "0.967" "0.970" "0.983" "0.981" "0.979" "3647.8" "3562.4" "3587.6" "3343.0" "3379.6" "3525.9" "3537.5" "3584.7" "3578.9" "3569.9" "" "" "" "" "" "" "" "" "" "" "3647.8" "3013.9" "2268.5" "2437.5" "2768.9" "2738.2" "2726.8" "3082.1" "2793.5" "3209.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "91.186" "21" "15" "29" "15" "873" "97.6" "4.60" "92.58" "15" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "0.946" "0.844" "0.972" "0.985" "0.838" "1.004" "0.956" "0.835" "0.888" "1356.4" "1282.6" "1144.6" "1317.8" "1335.8" "1137.1" "1361.2" "1297.0" "1132.4" "1205.1" "" "" "" "" "" "" "" "" "" "" "1356.4" "1085.1" "723.7" "960.9" "1094.4" "883.0" "1049.3" "1115.2" "883.9" "1083.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "91.049" "18" "16" "26" "16" "962" "107.8" "4.91" "92.06" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "3" "0" "1.066" "1.086" "1.012" "1.031" "0.966" "1.013" "1.041" "1.034" "1.025" "876.8" "935.0" "951.7" "887.0" "903.9" "846.9" "888.0" "912.3" "906.7" "898.4" "" "" "" "" "" "" "" "" "" "" "876.8" "791.0" "601.8" "646.7" "740.5" "657.7" "684.5" "784.4" "707.7" "807.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "91.035" "36" "17" "33" "17" "519" "56.1" "7.93" "109.35" "17" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "0.954" "1.054" "1.017" "0.981" "1.068" "1.029" "0.989" "1.057" "1.068" "2068.5" "1973.8" "2180.4" "2103.1" "2029.4" "2209.3" "2129.2" "2046.5" "2187.3" "2208.7" "" "" "" "" "" "" "" "" "" "" "2068.5" "1669.9" "1378.7" "1533.5" "1662.7" "1715.7" "1641.3" "1759.6" "1707.3" "1985.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "90.613" "20" "19" "33" "18" "913" "105.3" "5.68" "108.76" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "1" "0.943" "1.068" "0.997" "1.034" "1.060" "1.038" "1.051" "1.008" "1.026" "1615.5" "1523.6" "1726.1" "1610.2" "1670.1" "1713.1" "1677.1" "1697.6" "1628.1" "1658.0" "" "" "" "" "" "" "" "" "" "" "1615.5" "1289.0" "1091.4" "1174.1" "1368.3" "1330.4" "1292.8" "1459.6" "1270.8" "1490.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "90.074" "23" "19" "24" "19" "906" "102.4" "5.27" "85.86" "19" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.968" "0.958" "0.981" "0.934" "0.911" "0.962" "0.967" "0.909" "0.938" "2120.3" "2052.1" "2031.4" "2080.9" "1979.8" "1931.4" "2039.3" "2051.1" "1927.8" "1988.1" "" "" "" "" "" "" "" "" "" "" "2120.3" "1736.1" "1284.4" "1517.3" "1622.0" "1499.9" "1572.0" "1763.5" "1504.8" "1787.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "90.057" "25" "14" "26" "13" "623" "62.0" "5.24" "93.43" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "" "Formation of the cornified envelope" "2" "0" "0.438" "0.273" "0.307" "0.224" "0.319" "0.124" "0.246" "0.753" "0.171" "4174.4" "1827.0" "1139.5" "1280.3" "934.5" "1332.4" "518.5" "1025.0" "3141.3" "712.5" "" "" "" "" "" "" "" "" "" "" "4174.4" "1545.7" "720.5" "933.6" "765.6" "1034.7" "399.7" "881.3" "2452.0" "640.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "90.035" "23" "16" "35" "16" "793" "88.8" "5.22" "111.47" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.067" "1.258" "1.122" "1.080" "1.233" "1.097" "1.088" "1.210" "1.109" "1948.3" "2079.6" "2450.7" "2186.0" "2104.9" "2401.8" "2137.0" "2120.1" "2357.1" "2160.5" "" "" "" "" "" "" "" "" "" "" "1948.3" "1759.4" "1549.6" "1593.9" "1724.6" "1865.2" "1647.2" "1822.9" "1839.9" "1942.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "90.024" "19" "20" "38" "20" "1071" "123.3" "6.06" "113.42" "20" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "19" "0" "1.010" "0.953" "0.943" "0.916" "0.897" "0.949" "0.987" "0.953" "0.949" "1772.9" "1790.7" "1689.0" "1671.9" "1624.9" "1590.9" "1683.4" "1749.8" "1689.4" "1683.4" "" "" "" "" "" "" "" "" "" "" "1772.9" "1515.0" "1067.9" "1219.1" "1331.3" "1235.5" "1297.6" "1504.5" "1318.7" "1513.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "89.846" "38" "15" "33" "15" "433" "48.6" "5.95" "113.12" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of expression of SLITs and ROBOs; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Downstream TCR signaling; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.015" "0.955" "1.035" "0.987" "0.972" "0.973" "1.026" "0.974" "0.979" "2041.7" "2072.5" "1950.7" "2113.7" "2015.4" "1984.7" "1987.0" "2095.8" "1987.6" "1998.0" "" "" "" "" "" "" "" "" "" "" "2041.7" "1753.4" "1233.4" "1541.2" "1651.2" "1541.3" "1531.6" "1801.9" "1551.4" "1796.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "89.545" "28" "16" "29" "16" "595" "67.5" "7.78" "99.96" "16" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "Neutrophil degranulation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PD-1 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "33" "0" "1.015" "0.999" "0.980" "0.996" "0.971" "0.965" "1.044" "0.935" "0.967" "2074.3" "2106.4" "2071.9" "2032.0" "2065.5" "2014.3" "2002.5" "2165.2" "1938.8" "2005.7" "" "" "" "" "" "" "" "" "" "" "2074.3" "1782.0" "1310.1" "1481.6" "1692.3" "1564.3" "1543.6" "1861.7" "1513.4" "1803.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "89.398" "37" "13" "21" "13" "432" "46.5" "6.39" "73.53" "13" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "5" "0" "1.052" "1.091" "1.019" "0.984" "1.033" "1.006" "0.973" "1.041" "1.006" "1620.2" "1704.4" "1767.3" "1651.8" "1594.0" "1673.8" "1630.4" "1577.2" "1686.1" "1630.0" "" "" "" "" "" "" "" "" "" "" "1620.2" "1442.0" "1117.4" "1204.4" "1306.0" "1299.8" "1256.8" "1356.0" "1316.1" "1465.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "88.644" "27" "15" "22" "15" "633" "69.2" "7.58" "77.16" "15" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "" "Mitochondrial protein degradation" "1" "0" "0.932" "0.805" "0.980" "1.011" "0.854" "0.988" "0.971" "0.846" "0.898" "871.5" "812.1" "701.7" "853.8" "880.8" "744.0" "861.4" "846.3" "737.4" "782.6" "" "" "" "" "" "" "" "" "" "" "871.5" "687.1" "443.7" "622.5" "721.7" "577.8" "664.0" "727.6" "575.6" "703.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "88.582" "26" "19" "30" "18" "775" "87.7" "7.15" "102.36" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.007" "0.992" "1.028" "1.010" "1.013" "1.028" "1.007" "0.956" "1.041" "1547.3" "1558.5" "1534.4" "1591.3" "1563.2" "1567.8" "1590.4" "1557.5" "1479.5" "1611.4" "" "" "" "" "" "" "" "" "" "" "1547.3" "1318.5" "970.2" "1160.3" "1280.7" "1217.5" "1225.9" "1339.1" "1154.8" "1448.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "88.225" "29" "15" "45" "12" "558" "63.1" "8.32" "142.59" "15" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "13" "3" "0.981" "1.108" "0.979" "0.968" "0.999" "0.943" "0.979" "1.023" "1.014" "2636.9" "2586.2" "2922.3" "2582.7" "2552.4" "2634.3" "2487.2" "2581.3" "2697.1" "2672.9" "" "" "" "" "" "" "" "" "" "" "2636.9" "2188.0" "1847.8" "1883.1" "2091.2" "2045.8" "1917.2" "2219.4" "2105.2" "2403.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "88.003" "27" "13" "30" "12" "541" "61.1" "6.76" "93.20" "13" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "2" "1.027" "0.947" "1.082" "1.052" "0.941" "1.013" "1.004" "0.906" "0.984" "1518.4" "1559.8" "1437.8" "1642.4" "1596.9" "1428.2" "1538.0" "1524.1" "1375.8" "1493.5" "" "" "" "" "" "" "" "" "" "" "1518.4" "1319.6" "909.2" "1197.6" "1308.3" "1109.1" "1185.5" "1310.4" "1073.9" "1342.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "87.914" "29" "13" "28" "13" "567" "60.2" "4.78" "86.29" "13" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.042" "1.152" "1.048" "1.075" "1.031" "1.017" "1.031" "1.072" "1.087" "1076.3" "1121.5" "1239.8" "1127.6" "1157.5" "1109.9" "1094.1" "1109.9" "1154.3" "1170.1" "" "" "" "" "" "" "" "" "" "" "1076.3" "948.8" "783.9" "822.2" "948.3" "862.0" "843.4" "954.3" "901.0" "1052.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "87.885" "30" "12" "26" "12" "478" "52.9" "5.82" "98.52" "12" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "0.998" "1.095" "1.016" "1.078" "1.173" "1.081" "0.999" "1.086" "1.050" "1188.6" "1186.6" "1300.9" "1207.1" "1281.5" "1394.6" "1284.6" "1187.9" "1291.2" "1248.1" "" "" "" "" "" "" "" "" "" "" "1188.6" "1003.9" "822.6" "880.2" "1049.9" "1083.0" "990.2" "1021.3" "1007.9" "1122.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "87.810" "37" "16" "41" "16" "475" "51.9" "8.06" "131.02" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "7" "0" "0.974" "1.070" "1.011" "0.939" "1.033" "0.921" "0.959" "1.089" "0.984" "2361.8" "2300.8" "2527.7" "2387.9" "2217.8" "2438.5" "2175.0" "2264.1" "2571.5" "2323.1" "" "" "" "" "" "" "" "" "" "" "2361.8" "1946.5" "1598.3" "1741.1" "1817.1" "1893.7" "1676.6" "1946.6" "2007.2" "2088.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "87.726" "13" "14" "19" "14" "1227" "140.4" "6.54" "76.05" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "1.054" "0.917" "1.002" "1.080" "1.002" "1.045" "1.090" "0.922" "0.997" "832.5" "877.0" "763.0" "834.4" "899.1" "834.1" "869.9" "907.2" "767.8" "829.8" "" "" "" "" "" "" "" "" "" "" "832.5" "742.0" "482.4" "608.4" "736.7" "647.7" "670.5" "780.0" "599.3" "746.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "87.701" "48" "15" "61" "13" "353" "37.4" "8.95" "177.11" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA processing" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "2" "1.076" "1.314" "0.997" "1.062" "1.313" "1.070" "1.039" "1.360" "1.129" "2523.4" "2715.0" "3315.2" "2516.4" "2680.5" "3314.3" "2700.8" "2622.8" "3432.1" "2849.1" "" "" "" "" "" "" "" "" "" "" "2523.4" "2297.0" "2096.2" "1834.8" "2196.1" "2573.8" "2081.9" "2255.1" "2679.0" "2561.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "87.007" "30" "15" "109" "15" "462" "50.1" "9.01" "313.98" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Peptide chain elongation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; SARS-CoV-1 modulates host translation machinery" "20" "0" "0.928" "0.964" "0.858" "0.916" "0.961" "0.872" "0.929" "0.894" "0.900" "6157.6" "5714.1" "5935.3" "5281.7" "5638.6" "5917.6" "5367.6" "5719.9" "5502.3" "5541.7" "" "" "" "" "" "" "" "" "" "" "6157.6" "4834.3" "3752.9" "3851.1" "4619.8" "4595.5" "4137.5" "4918.0" "4294.9" "4982.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "86.971" "19" "14" "35" "11" "894" "95.3" "8.76" "115.23" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "2" "2" "1.052" "1.290" "1.116" "1.082" "1.270" "1.098" "1.054" "1.296" "1.129" "1166.7" "1227.2" "1504.6" "1302.4" "1262.2" "1481.4" "1281.2" "1229.9" "1511.8" "1316.7" "" "" "" "" "" "" "" "" "" "" "1166.7" "1038.3" "951.4" "949.6" "1034.1" "1150.4" "987.6" "1057.5" "1180.1" "1183.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "86.887" "24" "15" "36" "12" "636" "70.6" "9.50" "109.57" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "4" "1.067" "1.033" "1.041" "1.009" "1.000" "1.017" "1.027" "1.010" "0.987" "2318.0" "2472.5" "2394.4" "2413.4" "2337.9" "2317.1" "2356.7" "2381.0" "2340.2" "2287.6" "" "" "" "" "" "" "" "" "" "" "2318.0" "2091.8" "1514.0" "1759.7" "1915.4" "1799.4" "1816.6" "2047.1" "1826.7" "2056.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "86.886" "24" "14" "33" "14" "611" "69.2" "6.18" "105.18" "14" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "12" "0" "1.010" "1.064" "1.006" "0.988" "1.051" "0.950" "1.003" "1.110" "1.069" "1357.7" "1371.7" "1443.9" "1365.9" "1342.0" "1426.4" "1290.0" "1361.6" "1506.7" "1451.1" "" "" "" "" "" "" "" "" "" "" "1357.7" "1160.5" "913.0" "996.0" "1099.5" "1107.7" "994.4" "1170.7" "1176.1" "1304.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "86.837" "26" "19" "35" "19" "723" "83.4" "6.67" "103.01" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.995" "1.037" "1.002" "0.998" "1.077" "1.004" "0.988" "1.022" "1.076" "2209.1" "2197.5" "2290.5" "2213.8" "2204.9" "2378.9" "2217.7" "2183.4" "2257.1" "2376.3" "" "" "" "" "" "" "" "" "" "" "2209.1" "1859.1" "1448.3" "1614.2" "1806.5" "1847.4" "1709.5" "1877.3" "1761.8" "2136.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "86.834" "17" "17" "26" "17" "1292" "141.2" "5.12" "94.84" "17" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.990" "1.014" "1.018" "1.023" "0.974" "1.099" "1.022" "0.975" "1.026" "602.1" "596.1" "610.5" "612.9" "616.2" "586.7" "661.8" "615.5" "586.9" "617.5" "" "" "" "" "" "" "" "" "" "" "602.1" "504.3" "386.0" "446.9" "504.8" "455.6" "510.2" "529.2" "458.1" "555.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "86.609" "22" "17" "21" "16" "917" "102.3" "6.05" "74.33" "17" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis" "7" "1" "1.008" "0.999" "1.055" "1.037" "0.977" "1.066" "1.035" "0.959" "1.013" "1247.4" "1257.5" "1246.6" "1316.5" "1293.2" "1219.3" "1329.5" "1290.5" "1196.4" "1264.2" "" "" "" "" "" "" "" "" "" "" "1247.4" "1063.9" "788.3" "960.0" "1059.5" "946.9" "1024.8" "1109.6" "933.9" "1136.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "86.290" "18" "16" "22" "16" "934" "104.7" "5.77" "81.99" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "12" "0" "1.042" "0.847" "0.972" "1.021" "0.873" "1.024" "1.029" "0.821" "1.025" "1953.4" "2034.7" "1654.4" "1899.1" "1994.7" "1706.3" "1999.9" "2009.6" "1603.0" "2001.8" "" "" "" "" "" "" "" "" "" "" "1953.4" "1721.4" "1046.1" "1384.7" "1634.3" "1325.0" "1541.6" "1727.9" "1251.2" "1799.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "86.115" "18" "16" "24" "16" "944" "103.0" "6.07" "76.47" "16" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.019" "0.919" "1.024" "0.989" "0.851" "0.981" "1.034" "0.842" "0.931" "1349.3" "1374.9" "1239.7" "1381.8" "1334.3" "1148.1" "1323.4" "1395.8" "1135.9" "1255.6" "" "" "" "" "" "" "" "" "" "" "1349.3" "1163.2" "783.9" "1007.5" "1093.2" "891.6" "1020.2" "1200.1" "886.6" "1128.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "86.028" "36" "23" "42" "15" "586" "69.4" "6.27" "132.89" "23" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "11" "1" "0.997" "1.193" "1.024" "1.002" "1.187" "0.983" "0.977" "1.218" "1.057" "1969.6" "1964.2" "2350.0" "2016.7" "1974.5" "2337.9" "1935.8" "1925.1" "2399.0" "2081.7" "" "" "" "" "" "" "" "" "" "" "1969.6" "1661.8" "1485.9" "1470.5" "1617.7" "1815.6" "1492.2" "1655.2" "1872.6" "1871.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "85.915" "40" "16" "30" "16" "376" "42.9" "5.81" "101.70" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "ER-Phagosome pathway; Neutrophil degranulation; Downstream TCR signaling; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; Regulation of RUNX2 expression and activity; Separation of Sister Chromatids; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.961" "0.965" "0.926" "0.925" "0.880" "0.933" "0.988" "0.881" "0.964" "1436.2" "1379.7" "1386.0" "1330.3" "1329.0" "1264.4" "1340.2" "1419.0" "1266.0" "1384.1" "" "" "" "" "" "" "" "" "" "" "1436.2" "1167.3" "876.4" "970.0" "1088.9" "981.9" "1033.1" "1220.0" "988.2" "1244.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "85.771" "16" "23" "26" "23" "1411" "162.4" "5.68" "90.71" "23" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "VEGFA-VEGFR2 signaling" "Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "1.034" "1.047" "1.082" "1.020" "1.077" "1.075" "1.037" "1.035" "1.043" "1479.3" "1530.1" "1549.1" "1600.0" "1509.0" "1593.3" "1590.1" "1534.5" "1531.1" "1542.8" "" "" "" "" "" "" "" "" "" "" "1479.3" "1294.5" "979.5" "1166.6" "1236.3" "1237.3" "1225.7" "1319.3" "1195.1" "1387.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "85.451" "30" "9" "29" "3" "449" "49.2" "6.30" "97.66" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "6" "6" "1.084" "0.953" "1.102" "1.051" "0.904" "1.055" "1.028" "0.999" "1.112" "1002.4" "1086.8" "955.5" "1105.1" "1053.5" "906.0" "1057.9" "1030.1" "1001.0" "1114.3" "" "" "" "" "" "" "" "" "" "" "1002.4" "919.4" "604.2" "805.7" "863.1" "703.6" "815.5" "885.6" "781.3" "1001.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "84.992" "9" "21" "27" "21" "2346" "265.4" "6.37" "89.46" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "24" "0" "0.987" "0.792" "0.994" "0.990" "0.834" "0.975" "0.991" "0.835" "0.889" "1057.0" "1042.9" "836.8" "1051.1" "1046.8" "881.6" "1030.1" "1047.7" "882.3" "940.0" "" "" "" "" "" "" "" "" "" "" "1057.0" "882.3" "529.1" "766.4" "857.6" "684.6" "794.0" "900.8" "688.7" "845.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8002824658858050550" "False" "High" "IsMasterProtein" "Q13087" "Protein disulfide-isomerase A2 OS=Homo sapiens OX=9606 GN=PDIA2 PE=1 SV=2" "0.000" "False" "84.872" "31" "15" "21" "15" "525" "58.2" "4.98" "77.63" "15" "cell adhesion;protein metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf13848" "64714" "ENSG00000185615" "PDIA2" "A6ZJ64; B4DI27; hsa:64714; Q13087; Q2WGM4; Q4TT67; Q6B010; Q96KJ6; Q9BW95" "Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "" "2" "0" "1.094" "1.073" "1.041" "1.067" "1.082" "1.080" "1.062" "1.108" "1.147" "1024.9" "1121.2" "1099.8" "1067.2" "1093.6" "1108.5" "1107.2" "1088.7" "1135.5" "1175.1" "" "" "" "" "" "" "" "" "" "" "1024.9" "948.6" "695.4" "778.2" "896.0" "860.8" "853.4" "936.0" "886.3" "1056.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "84.795" "25" "15" "23" "15" "741" "82.5" "5.06" "76.34" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "2q11.2 copy number variation syndrome" "Condensation of Prometaphase Chromosomes" "2" "0" "0.976" "0.731" "1.019" "0.995" "0.753" "0.993" "0.977" "0.736" "0.943" "1590.7" "1552.1" "1162.2" "1621.0" "1582.4" "1197.9" "1579.1" "1554.7" "1171.3" "1499.8" "" "" "" "" "" "" "" "" "" "" "1590.7" "1313.1" "734.8" "1181.9" "1296.5" "930.3" "1217.3" "1336.7" "914.2" "1348.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "84.583" "38" "11" "27" "11" "350" "38.4" "5.12" "101.33" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "Downregulation of TGF-beta receptor signaling" "3" "0" "0.957" "0.922" "0.992" "0.922" "0.890" "0.947" "0.979" "0.860" "0.957" "1936.6" "1853.6" "1784.8" "1921.5" "1786.5" "1723.8" "1833.6" "1896.5" "1665.3" "1853.8" "" "" "" "" "" "" "" "" "" "" "1936.6" "1568.2" "1128.5" "1401.1" "1463.7" "1338.6" "1413.4" "1630.6" "1299.8" "1666.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "84.555" "36" "13" "34" "9" "447" "50.6" "5.14" "104.63" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "Ciliary landscape; Airway smooth muscle cell contraction" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "1.100" "1.191" "1.069" "1.065" "1.165" "1.024" "1.036" "1.133" "1.090" "704.5" "775.0" "838.8" "753.3" "750.5" "820.9" "721.2" "730.0" "797.9" "768.1" "" "" "" "" "" "" "" "" "" "" "704.5" "655.6" "530.4" "549.3" "614.9" "637.5" "555.9" "627.6" "622.8" "690.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "84.457" "29" "13" "35" "13" "486" "54.0" "4.81" "129.67" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "" "3" "0" "0.972" "0.974" "0.962" "0.981" "0.925" "0.999" "1.012" "0.888" "0.927" "2755.7" "2677.5" "2685.0" "2650.5" "2704.0" "2548.2" "2753.6" "2788.7" "2447.1" "2555.2" "" "" "" "" "" "" "" "" "" "" "2755.7" "2265.3" "1697.7" "1932.6" "2215.4" "1978.9" "2122.6" "2397.7" "1910.1" "2297.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "84.186" "20" "21" "30" "21" "1102" "128.2" "5.55" "93.31" "21" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Regulation of TP53 Degradation; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of PTEN localization" "10" "0" "1.011" "0.923" "1.019" "1.020" "0.943" "1.006" "1.058" "0.935" "0.996" "2291.8" "2316.7" "2114.6" "2336.1" "2338.2" "2160.9" "2305.3" "2425.1" "2143.8" "2283.8" "" "" "" "" "" "" "" "" "" "" "2291.8" "1960.0" "1337.1" "1703.3" "1915.7" "1678.1" "1777.0" "2085.1" "1673.4" "2053.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "84.120" "31" "13" "29" "13" "472" "51.1" "8.40" "94.74" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "14" "0" "1.029" "0.937" "0.987" "0.966" "0.924" "0.950" "0.974" "0.914" "0.976" "1782.8" "1834.2" "1669.8" "1759.1" "1722.9" "1646.8" "1693.8" "1735.6" "1629.6" "1740.6" "" "" "" "" "" "" "" "" "" "" "1782.8" "1551.7" "1055.8" "1282.6" "1411.6" "1278.9" "1305.7" "1492.3" "1272.0" "1564.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "83.875" "21" "16" "25" "14" "925" "100.1" "7.28" "79.82" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "21" "1" "1.085" "0.844" "1.105" "1.062" "0.845" "1.103" "1.156" "0.990" "0.960" "431.2" "467.8" "364.1" "476.6" "457.9" "364.5" "475.4" "498.4" "426.7" "414.0" "" "" "" "" "" "" "" "" "" "" "431.2" "395.8" "230.2" "347.5" "375.2" "283.1" "366.5" "428.5" "333.1" "372.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "83.721" "36" "18" "29" "18" "511" "57.2" "6.21" "86.66" "18" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "miR-517 relationship with ARCN1 and USP1" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "0.976" "1.012" "0.990" "0.969" "0.970" "0.957" "0.972" "0.986" "0.982" "1853.3" "1809.0" "1874.8" "1835.5" "1796.7" "1797.4" "1773.1" "1801.9" "1827.1" "1819.6" "" "" "" "" "" "" "" "" "" "" "1853.3" "1530.5" "1185.4" "1338.3" "1472.0" "1395.8" "1366.8" "1549.3" "1426.2" "1635.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "83.664" "48" "17" "34" "15" "406" "45.6" "7.55" "100.19" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; UCH proteinases; Ub-specific processing proteases; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.032" "0.970" "1.011" "1.026" "0.982" "1.028" "0.998" "0.956" "1.032" "1403.9" "1449.4" "1361.5" "1419.9" "1440.9" "1378.4" "1443.8" "1400.7" "1342.1" "1449.2" "" "" "" "" "" "" "" "" "" "" "1403.9" "1226.2" "860.9" "1035.3" "1180.5" "1070.4" "1112.9" "1204.3" "1047.6" "1302.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "83.446" "32" "14" "39" "14" "483" "53.1" "7.23" "129.32" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "7" "0" "0.981" "1.031" "1.021" "0.984" "0.978" "1.000" "0.977" "1.006" "1.022" "2296.9" "2252.4" "2368.4" "2344.3" "2261.0" "2246.1" "2297.4" "2243.0" "2311.6" "2347.4" "" "" "" "" "" "" "" "" "" "" "2296.9" "1905.6" "1497.5" "1709.3" "1852.4" "1744.3" "1770.9" "1928.5" "1804.3" "2110.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1891313115093296053" "False" "High" "IsMasterProtein" "P21980" "Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens OX=9606 GN=TGM2 PE=1 SV=2" "0.000" "False" "83.418" "28" "16" "33" "16" "687" "77.3" "5.22" "102.68" "16" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00868, Pf00927, Pf01841" "7052" "ENSG00000198959" "TGM2" "E1P5V9; hsa:7052; P21980; Q16436; Q6B838; Q9BTN7; Q9H035; Q9UH35" "IL-18 signaling pathway" "" "1" "0" "1.002" "1.061" "0.975" "1.030" "1.017" "0.944" "1.014" "1.000" "1.044" "1433.8" "1437.0" "1520.9" "1398.2" "1477.0" "1457.8" "1354.0" "1454.1" "1434.0" "1496.5" "" "" "" "" "" "" "" "" "" "" "1433.8" "1215.8" "961.7" "1019.5" "1210.1" "1132.1" "1043.7" "1250.3" "1119.3" "1345.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "83.346" "37" "11" "32" "11" "397" "41.9" "8.09" "120.76" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Fatty acid biosynthesis" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.985" "1.021" "0.951" "1.016" "0.982" "0.961" "0.956" "1.000" "1.008" "1504.8" "1482.4" "1536.5" "1431.8" "1528.4" "1478.4" "1446.8" "1439.3" "1505.4" "1517.1" "" "" "" "" "" "" "" "" "" "" "1504.8" "1254.1" "971.6" "1044.0" "1252.2" "1148.1" "1115.3" "1237.5" "1175.1" "1364.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "83.278" "24" "15" "30" "13" "780" "85.1" "7.99" "97.34" "15" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "0" "1.018" "1.019" "1.032" "0.961" "1.043" "0.927" "0.963" "1.103" "1.014" "1069.8" "1089.1" "1090.0" "1104.3" "1028.2" "1116.4" "991.8" "1030.1" "1180.2" "1084.8" "" "" "" "" "" "" "" "" "" "" "1069.8" "921.4" "689.2" "805.2" "842.4" "866.9" "764.5" "885.7" "921.2" "975.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "83.211" "28" "14" "25" "12" "522" "59.0" "5.15" "83.61" "14" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "2" "1.011" "0.984" "0.983" "0.976" "0.984" "0.945" "0.977" "0.972" "1.012" "2135.1" "2157.6" "2100.1" "2098.4" "2083.6" "2101.7" "2018.4" "2084.9" "2076.0" "2160.1" "" "" "" "" "" "" "" "" "" "" "2135.1" "1825.4" "1327.9" "1530.0" "1707.1" "1632.2" "1555.9" "1792.6" "1620.5" "1942.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "83.104" "11" "17" "24" "10" "1647" "184.5" "7.88" "74.58" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "13" "4" "1.068" "0.847" "1.112" "1.049" "0.851" "1.129" "1.058" "0.888" "0.970" "837.8" "894.4" "710.0" "931.7" "878.4" "712.8" "945.7" "886.5" "743.6" "812.3" "" "" "" "" "" "" "" "" "" "" "837.8" "756.7" "448.9" "679.3" "719.7" "553.6" "729.0" "762.2" "580.4" "730.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "83.093" "22" "21" "31" "21" "986" "111.5" "7.27" "100.57" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "Pathogenic Escherichia coli infection" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "5" "0" "1.032" "0.842" "1.048" "1.071" "0.861" "1.059" "1.107" "0.806" "0.889" "1722.4" "1777.6" "1450.2" "1805.0" "1844.6" "1482.4" "1823.7" "1905.9" "1388.6" "1531.8" "" "" "" "" "" "" "" "" "" "" "1722.4" "1503.9" "917.0" "1316.1" "1511.3" "1151.2" "1405.8" "1638.7" "1083.9" "1377.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "83.034" "24" "17" "23" "17" "768" "88.9" "8.48" "78.93" "17" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "16" "0" "0.972" "0.969" "0.981" "0.956" "0.924" "0.936" "0.941" "0.931" "0.957" "1431.4" "1390.8" "1386.8" "1404.4" "1368.4" "1322.1" "1340.5" "1347.5" "1333.3" "1370.1" "" "" "" "" "" "" "" "" "" "" "1431.4" "1176.7" "876.9" "1024.0" "1121.1" "1026.7" "1033.3" "1158.5" "1040.7" "1231.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "82.985" "28" "12" "33" "12" "508" "57.5" "7.80" "102.04" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.938" "1.008" "0.995" "1.009" "1.017" "0.993" "0.895" "0.982" "1.085" "929.3" "871.9" "937.1" "924.5" "938.0" "944.8" "922.4" "832.1" "912.9" "1008.6" "" "" "" "" "" "" "" "" "" "" "929.3" "737.6" "592.5" "674.1" "768.5" "733.7" "711.0" "715.4" "712.6" "906.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "82.704" "28" "16" "25" "16" "564" "66.7" "6.34" "86.84" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "0.995" "1.101" "1.005" "1.051" "1.063" "1.013" "1.026" "1.042" "1.005" "1866.3" "1856.1" "2054.5" "1876.2" "1961.3" "1983.1" "1891.3" "1914.6" "1944.0" "1876.5" "" "" "" "" "" "" "" "" "" "" "1866.3" "1570.3" "1299.1" "1368.0" "1606.9" "1540.1" "1457.9" "1646.2" "1517.4" "1687.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "82.636" "27" "16" "22" "16" "708" "79.8" "5.74" "79.17" "16" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "1.035" "0.878" "1.103" "1.068" "0.906" "1.071" "1.083" "0.926" "1.025" "949.7" "982.6" "833.8" "1048.0" "1014.7" "860.3" "1017.2" "1028.8" "879.6" "973.5" "" "" "" "" "" "" "" "" "" "" "949.7" "831.3" "527.2" "764.2" "831.3" "668.1" "784.1" "884.5" "686.6" "875.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "82.466" "42" "11" "35" "11" "324" "36.7" "6.06" "122.50" "11" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "" "Platelet degranulation" "1" "0" "1.072" "1.127" "1.011" "1.055" "1.091" "0.997" "1.050" "1.130" "1.095" "2015.9" "2160.3" "2271.8" "2037.4" "2127.4" "2200.1" "2010.0" "2116.1" "2278.5" "2207.4" "" "" "" "" "" "" "" "" "" "" "2015.9" "1827.7" "1436.5" "1485.5" "1743.0" "1708.6" "1549.4" "1819.4" "1778.5" "1984.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "82.394" "16" "12" "25" "12" "938" "102.9" "7.02" "98.35" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.045" "1.009" "0.995" "1.088" "1.066" "1.021" "1.034" "1.063" "1.104" "1276.9" "1334.0" "1287.8" "1270.3" "1389.6" "1361.5" "1303.1" "1320.2" "1356.7" "1409.8" "" "" "" "" "" "" "" "" "" "" "1276.9" "1128.6" "814.3" "926.2" "1138.5" "1057.3" "1004.4" "1135.1" "1059.0" "1267.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3092870897652950663" "False" "High" "IsMasterProtein" "O14841" "5-oxoprolinase OS=Homo sapiens OX=9606 GN=OPLAH PE=1 SV=3" "0.000" "False" "82.388" "13" "14" "19" "14" "1288" "137.4" "6.58" "72.52" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf01968, Pf02538, Pf05378, Pf19278" "26873" "ENSG00000178814" "OPLAH" "A5PKY8; hsa:26873; O14841; Q75W65; Q9Y4Q0" "Glutathione metabolism" "Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD" "3" "0" "1.031" "1.071" "1.066" "1.054" "1.013" "1.034" "1.053" "1.071" "1.097" "911.9" "940.2" "976.7" "972.5" "960.7" "923.6" "942.6" "960.6" "976.9" "1000.0" "" "" "" "" "" "" "" "" "" "" "911.9" "795.4" "617.6" "709.1" "787.1" "717.2" "726.6" "825.9" "762.5" "899.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915222884888566270" "False" "High" "IsMasterProtein" "O15020" "Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3" "0.000" "False" "81.855" "9" "25" "26" "23" "2390" "271.2" "6.11" "80.99" "25" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "6712" "ENSG00000173898" "SPTBN2" "hsa:6712; O14872; O14873; O15020" "" "MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "5" "0" "1.080" "1.234" "1.110" "1.125" "1.308" "1.120" "1.074" "1.287" "1.169" "1491.2" "1610.2" "1839.7" "1655.7" "1676.9" "1950.9" "1669.7" "1600.9" "1919.9" "1743.3" "" "" "" "" "" "" "" "" "" "" "1491.2" "1362.2" "1163.3" "1207.3" "1373.9" "1515.0" "1287.1" "1376.4" "1498.6" "1567.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "81.820" "30" "11" "28" "11" "394" "43.8" "6.55" "99.79" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "" "Neutrophil degranulation" "1" "0" "1.030" "1.410" "1.007" "1.060" "1.533" "1.017" "0.985" "1.574" "1.164" "1474.8" "1518.6" "2080.0" "1484.7" "1562.9" "2261.0" "1499.9" "1453.1" "2321.8" "1716.4" "" "" "" "" "" "" "" "" "" "" "1474.8" "1284.8" "1315.2" "1082.5" "1280.5" "1755.8" "1156.2" "1249.4" "1812.3" "1543.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "81.802" "13" "21" "25" "21" "1824" "206.7" "6.47" "78.89" "21" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "" "3" "0" "1.026" "1.086" "0.996" "0.942" "1.077" "0.976" "1.013" "1.111" "0.977" "768.7" "789.0" "834.9" "765.6" "723.8" "827.9" "750.4" "778.7" "854.0" "751.2" "" "" "" "" "" "" "" "" "" "" "768.7" "667.5" "527.9" "558.3" "593.0" "642.9" "578.4" "669.5" "666.6" "675.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "81.459" "20" "14" "25" "13" "845" "95.9" "6.80" "85.20" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "IL-18 signaling pathway" "ABC-family proteins mediated transport" "2" "1" "1.129" "1.187" "1.004" "1.069" "1.155" "0.970" "0.982" "1.146" "1.053" "1128.2" "1273.9" "1339.0" "1132.7" "1205.8" "1303.5" "1094.5" "1108.3" "1292.7" "1188.4" "" "" "" "" "" "" "" "" "" "" "1128.2" "1077.8" "846.7" "825.9" "987.9" "1012.3" "843.7" "952.9" "1009.0" "1068.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "81.373" "29" "17" "29" "11" "509" "57.4" "5.88" "85.19" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Allograft rejection" "Cytosolic tRNA aminoacylation" "2" "2" "0.986" "1.030" "1.006" "1.000" "1.006" "0.990" "1.005" "1.074" "1.040" "1540.1" "1519.2" "1586.5" "1549.5" "1540.0" "1549.2" "1525.4" "1547.4" "1654.9" "1601.6" "" "" "" "" "" "" "" "" "" "" "1540.1" "1285.3" "1003.1" "1129.8" "1261.8" "1203.1" "1175.8" "1330.5" "1291.7" "1439.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "81.164" "59" "15" "33" "15" "243" "26.7" "9.66" "105.55" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.984" "1.220" "1.010" "1.091" "1.261" "1.073" "1.242" "1.240" "1.129" "1283.7" "1263.0" "1565.9" "1296.0" "1401.1" "1619.3" "1377.3" "1594.3" "1592.0" "1449.2" "" "" "" "" "" "" "" "" "" "" "1283.7" "1068.6" "990.1" "945.0" "1147.9" "1257.5" "1061.7" "1370.8" "1242.7" "1302.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "81.090" "33" "10" "21" "10" "370" "40.4" "7.66" "74.74" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "7" "0" "1.048" "0.970" "0.993" "0.988" "1.035" "0.927" "0.963" "1.058" "1.081" "666.0" "697.7" "645.8" "661.3" "657.7" "689.1" "617.7" "641.1" "704.7" "720.0" "" "" "" "" "" "" "" "" "" "" "666.0" "590.3" "408.3" "482.2" "538.8" "535.1" "476.1" "551.2" "550.0" "647.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "80.753" "45" "7" "20" "7" "227" "22.7" "4.63" "78.70" "7" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "" "RHOF GTPase cycle" "1" "0" "0.984" "1.160" "0.955" "0.970" "1.173" "1.109" "0.972" "1.144" "1.040" "1261.3" "1240.5" "1463.0" "1204.0" "1223.6" "1479.3" "1399.1" "1225.6" "1443.5" "1311.5" "" "" "" "" "" "" "" "" "" "" "1261.3" "1049.5" "925.1" "877.9" "1002.5" "1148.8" "1078.5" "1053.8" "1126.8" "1179.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "80.739" "59" "7" "84" "7" "140" "15.0" "8.27" "252.73" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "9" "0" "1.008" "1.072" "0.979" "1.010" "1.090" "0.968" "0.979" "1.081" "1.037" "3171.7" "3198.5" "3399.0" "3103.5" "3202.2" "3455.9" "3068.9" "3104.7" "3428.6" "3288.6" "" "" "" "" "" "" "" "" "" "" "3171.7" "2706.0" "2149.2" "2262.9" "2623.6" "2683.8" "2365.6" "2669.4" "2676.2" "2956.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "80.635" "31" "13" "22" "11" "519" "58.4" "5.12" "80.39" "13" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.029" "0.994" "1.057" "0.974" "1.012" "1.007" "1.060" "1.037" "1.014" "770.6" "792.9" "765.9" "814.3" "750.5" "779.5" "776.3" "817.0" "799.1" "781.6" "" "" "" "" "" "" "" "" "" "" "770.6" "670.8" "484.3" "593.7" "614.9" "605.3" "598.4" "702.4" "623.7" "702.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6719730535871434509" "False" "High" "IsMasterProtein" "P16989" "Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4" "0.000" "False" "80.487" "34" "8" "16" "6" "372" "40.1" "9.77" "70.61" "8" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00313" "8531" "ENSG00000060138" "YBX3" "B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76" "RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "2" "0.909" "0.918" "0.861" "0.887" "0.942" "0.899" "0.856" "0.983" "0.934" "862.6" "784.3" "791.4" "742.9" "765.3" "813.0" "775.6" "738.6" "848.1" "805.9" "" "" "" "" "" "" "" "" "" "" "862.6" "663.6" "500.4" "541.7" "627.0" "631.4" "597.9" "635.0" "662.0" "724.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "80.433" "17" "15" "24" "15" "998" "112.3" "6.39" "83.20" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "" "3" "0" "0.967" "0.815" "0.971" "0.989" "0.784" "1.001" "0.992" "0.773" "0.918" "1278.7" "1236.2" "1042.4" "1241.6" "1265.0" "1002.4" "1279.6" "1268.9" "988.7" "1173.7" "" "" "" "" "" "" "" "" "" "" "1278.7" "1045.8" "659.1" "905.3" "1036.4" "778.4" "986.3" "1091.0" "771.8" "1055.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "80.349" "16" "14" "29" "14" "953" "107.1" "6.05" "87.16" "14" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport" "3" "0" "1.027" "1.013" "1.062" "1.065" "0.972" "0.996" "1.043" "0.974" "0.968" "1032.2" "1059.6" "1045.6" "1096.5" "1099.1" "1003.3" "1028.2" "1076.2" "1005.2" "999.2" "" "" "" "" "" "" "" "" "" "" "1032.2" "896.4" "661.1" "799.5" "900.5" "779.2" "792.6" "925.3" "784.6" "898.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "80.269" "27" "12" "32" "12" "510" "54.6" "8.76" "104.82" "12" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.976" "1.064" "0.976" "0.968" "1.046" "0.917" "0.975" "1.017" "1.000" "2080.0" "2029.1" "2212.8" "2030.5" "2013.8" "2175.0" "1907.6" "2028.5" "2114.7" "2079.6" "" "" "" "" "" "" "" "" "" "" "2080.0" "1716.7" "1399.1" "1480.6" "1649.9" "1689.1" "1470.5" "1744.1" "1650.6" "1869.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.000" "False" "80.158" "14" "21" "25" "21" "1476" "164.7" "5.11" "77.92" "21" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "1.070" "0.908" "1.048" "1.013" "0.875" "1.115" "1.064" "0.896" "0.999" "619.3" "662.5" "562.4" "648.7" "627.6" "542.1" "690.7" "659.2" "554.7" "618.8" "" "" "" "" "" "" "" "" "" "" "619.3" "560.5" "355.6" "473.0" "514.2" "421.0" "532.4" "566.8" "433.0" "556.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "80.125" "15" "14" "24" "14" "1012" "113.7" "7.20" "81.79" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "2" "0" "0.965" "1.027" "0.964" "0.967" "1.020" "0.954" "0.965" "0.998" "1.014" "1819.4" "1755.6" "1869.1" "1753.7" "1760.3" "1856.5" "1735.5" "1756.4" "1816.4" "1844.5" "" "" "" "" "" "" "" "" "" "" "1819.4" "1485.2" "1181.9" "1278.7" "1442.2" "1441.7" "1337.8" "1510.1" "1417.8" "1658.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "80.038" "20" "18" "21" "18" "1011" "111.8" "8.75" "69.33" "18" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "1.054" "0.940" "1.029" "1.114" "0.937" "1.113" "1.123" "0.886" "0.988" "601.7" "633.9" "565.4" "619.3" "670.0" "563.7" "669.8" "675.6" "532.8" "594.6" "" "" "" "" "" "" "" "" "" "" "601.7" "536.3" "357.5" "451.6" "548.9" "437.8" "516.3" "580.8" "415.9" "534.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "79.974" "27" "12" "23" "12" "461" "49.9" "4.82" "82.21" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "0.980" "0.880" "0.983" "0.991" "0.912" "0.939" "1.030" "0.896" "0.988" "1119.1" "1096.5" "985.0" "1100.2" "1109.2" "1020.2" "1050.6" "1152.5" "1002.6" "1105.7" "" "" "" "" "" "" "" "" "" "" "1119.1" "927.7" "622.8" "802.2" "908.8" "792.2" "809.9" "991.0" "782.6" "994.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "79.744" "47" "9" "30" "9" "244" "25.9" "8.10" "100.75" "9" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "" "Formation of xylulose-5-phosphate; Essential pentosuria" "2" "0" "0.978" "0.998" "1.060" "1.031" "1.021" "1.035" "0.998" "0.981" "1.033" "659.8" "645.5" "658.6" "699.6" "680.3" "673.6" "682.6" "658.5" "647.5" "681.8" "" "" "" "" "" "" "" "" "" "" "659.8" "546.1" "416.4" "510.1" "557.4" "523.1" "526.2" "566.1" "505.4" "613.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "79.597" "20" "17" "22" "15" "975" "113.6" "5.94" "77.49" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "3" "2" "1.034" "0.875" "1.034" "1.042" "0.904" "1.006" "1.039" "0.904" "1.013" "981.6" "1014.6" "859.1" "1015.1" "1022.8" "887.8" "987.9" "1020.2" "887.5" "994.1" "" "" "" "" "" "" "" "" "" "" "981.6" "858.4" "543.2" "740.2" "838.0" "689.4" "761.5" "877.2" "692.7" "893.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "79.383" "32" "10" "30" "10" "380" "42.6" "8.62" "106.83" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "Base excision repair; DNA repair pathways, full network" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "8" "0" "0.999" "0.951" "1.022" "0.980" "1.002" "0.935" "0.959" "1.008" "0.985" "1432.7" "1430.6" "1362.3" "1464.3" "1403.5" "1436.0" "1339.3" "1374.6" "1444.4" "1411.1" "" "" "" "" "" "" "" "" "" "" "1432.7" "1210.3" "861.4" "1067.7" "1149.9" "1115.1" "1032.4" "1181.9" "1127.5" "1268.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "79.114" "33" "9" "30" "9" "318" "35.5" "8.12" "110.06" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "1.008" "1.062" "1.005" "1.020" "1.091" "0.953" "1.028" "1.061" "1.076" "1877.3" "1892.0" "1992.8" "1885.8" "1915.3" "2048.9" "1789.7" "1930.4" "1992.0" "2019.6" "" "" "" "" "" "" "" "" "" "" "1877.3" "1600.7" "1260.1" "1375.1" "1569.2" "1591.1" "1379.6" "1659.7" "1554.9" "1815.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "79.109" "50" "8" "39" "8" "189" "19.9" "6.79" "140.92" "8" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "8" "0" "0.976" "1.126" "1.010" "1.005" "1.039" "0.993" "0.981" "1.047" "1.004" "1979.9" "1931.4" "2229.1" "2000.5" "1989.2" "2056.5" "1966.1" "1941.7" "2072.9" "1987.9" "" "" "" "" "" "" "" "" "" "" "1979.9" "1634.0" "1409.5" "1458.6" "1629.8" "1597.0" "1515.5" "1669.5" "1618.1" "1787.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "79.057" "22" "14" "27" "14" "767" "86.4" "6.77" "80.58" "14" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.983" "0.746" "0.965" "0.986" "0.736" "0.916" "1.003" "0.734" "0.916" "1289.8" "1267.5" "961.7" "1245.1" "1271.3" "949.3" "1181.7" "1293.2" "946.9" "1181.0" "" "" "" "" "" "" "" "" "" "" "1289.8" "1072.3" "608.1" "907.8" "1041.6" "737.2" "910.9" "1111.9" "739.1" "1061.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "78.695" "36" "15" "25" "15" "422" "47.4" "6.48" "80.76" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.953" "0.934" "1.015" "1.000" "0.967" "0.951" "0.988" "0.913" "0.972" "1182.7" "1126.9" "1104.8" "1200.4" "1182.7" "1143.9" "1125.1" "1167.9" "1080.2" "1150.1" "" "" "" "" "" "" "" "" "" "" "1182.7" "953.4" "698.6" "875.3" "969.0" "888.4" "867.3" "1004.2" "843.1" "1034.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "78.692" "24" "16" "25" "15" "662" "73.2" "7.18" "84.90" "16" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "Neutrophil degranulation" "3" "0" "0.986" "0.829" "0.919" "0.958" "0.861" "0.913" "0.932" "0.850" "0.896" "1969.0" "1942.3" "1632.6" "1809.9" "1887.3" "1694.5" "1798.1" "1834.8" "1672.7" "1763.4" "" "" "" "" "" "" "" "" "" "" "1969.0" "1643.2" "1032.3" "1319.7" "1546.2" "1316.0" "1386.1" "1577.6" "1305.7" "1585.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "78.607" "19" "16" "30" "16" "908" "100.1" "5.20" "100.89" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; Neutrophil degranulation; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.990" "0.934" "0.969" "0.970" "0.907" "0.930" "0.995" "0.921" "0.974" "2532.9" "2508.6" "2364.7" "2455.1" "2456.6" "2298.3" "2354.7" "2519.3" "2333.7" "2468.1" "" "" "" "" "" "" "" "" "" "" "2532.9" "2122.3" "1495.2" "1790.1" "2012.7" "1784.8" "1815.1" "2166.1" "1821.6" "2219.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "78.334" "58" "13" "65" "9" "246" "28.2" "4.84" "177.25" "13" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "11" "1" "0.984" "1.046" "1.049" "0.976" "1.047" "1.012" "0.958" "1.036" "1.014" "1302.8" "1282.2" "1362.2" "1366.6" "1271.0" "1364.6" "1318.3" "1248.3" "1349.1" "1320.8" "" "" "" "" "" "" "" "" "" "" "1302.8" "1084.8" "861.4" "996.5" "1041.4" "1059.7" "1016.2" "1073.3" "1053.1" "1187.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "78.111" "7" "18" "23" "18" "2382" "250.6" "6.34" "72.98" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Ciliary landscape" "Stimuli-sensing channels" "2" "0" "0.993" "1.023" "1.030" "1.040" "1.049" "0.976" "1.015" "1.001" "1.008" "833.2" "827.3" "852.0" "858.1" "866.4" "874.0" "813.1" "845.8" "833.8" "839.6" "" "" "" "" "" "" "" "" "" "" "833.2" "699.9" "538.7" "625.6" "709.9" "678.7" "626.7" "727.3" "650.8" "754.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "78.103" "27" "11" "26" "11" "471" "53.1" "6.23" "83.28" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "1.022" "0.914" "0.927" "0.915" "0.916" "0.912" "1.021" "0.943" "0.955" "1336.5" "1366.5" "1221.4" "1238.4" "1223.0" "1224.0" "1218.8" "1364.1" "1259.7" "1276.2" "" "" "" "" "" "" "" "" "" "" "1336.5" "1156.1" "772.3" "903.0" "1002.0" "950.5" "939.5" "1172.8" "983.3" "1147.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "77.985" "16" "14" "23" "14" "1219" "133.5" "5.20" "72.93" "14" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "TYROBP causal network in microglia" "" "1" "0" "1.030" "0.997" "1.016" "1.042" "0.957" "1.078" "1.061" "0.975" "1.027" "832.7" "857.8" "830.3" "846.1" "867.8" "796.8" "897.6" "883.3" "812.2" "854.9" "" "" "" "" "" "" "" "" "" "" "832.7" "725.7" "525.0" "617.0" "711.0" "618.8" "691.9" "759.4" "634.0" "768.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "77.980" "50" "9" "25" "9" "261" "26.9" "7.78" "83.94" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "8" "0" "1.073" "1.091" "1.096" "1.090" "1.097" "1.090" "1.088" "1.048" "1.105" "889.3" "954.7" "970.3" "974.7" "969.3" "976.0" "969.1" "967.4" "931.7" "982.6" "" "" "" "" "" "" "" "" "" "" "889.3" "807.7" "613.5" "710.7" "794.2" "758.0" "747.0" "831.8" "727.2" "883.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "77.945" "17" "14" "34" "14" "944" "106.8" "6.14" "108.63" "14" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "N-glycan biosynthesis" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "5" "0" "0.981" "1.058" "1.026" "1.062" "1.035" "1.029" "1.025" "1.032" "1.006" "1729.3" "1697.0" "1829.8" "1774.5" "1836.6" "1790.1" "1779.0" "1771.7" "1784.5" "1740.0" "" "" "" "" "" "" "" "" "" "" "1729.3" "1435.7" "1157.0" "1293.9" "1504.8" "1390.2" "1371.3" "1523.3" "1392.9" "1564.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "77.669" "32" "10" "69" "7" "372" "38.7" "9.13" "211.58" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "6" "1" "1.058" "1.215" "0.944" "0.990" "1.230" "1.010" "0.994" "1.235" "1.144" "1999.1" "2114.8" "2428.5" "1886.9" "1979.4" "2458.5" "2018.7" "1988.0" "2468.1" "2287.5" "" "" "" "" "" "" "" "" "" "" "1999.1" "1789.1" "1535.6" "1375.8" "1621.7" "1909.2" "1556.1" "1709.3" "1926.5" "2056.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "77.552" "11" "22" "26" "22" "2005" "226.2" "7.30" "77.60" "22" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "1.044" "0.812" "1.061" "1.080" "0.854" "1.034" "1.033" "0.854" "1.061" "1113.4" "1162.8" "903.8" "1180.9" "1202.9" "950.8" "1151.7" "1150.0" "951.1" "1181.5" "" "" "" "" "" "" "" "" "" "" "1113.4" "983.7" "571.5" "861.0" "985.5" "738.4" "887.8" "988.8" "742.4" "1062.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "77.518" "27" "16" "33" "13" "589" "65.3" "5.11" "100.12" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; RAF activation; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "50" "3" "1.043" "1.017" "1.063" "1.016" "0.974" "0.996" "1.001" "1.015" "1.053" "2102.3" "2192.7" "2137.6" "2234.4" "2135.6" "2047.4" "2093.4" "2104.9" "2134.0" "2213.7" "" "" "" "" "" "" "" "" "" "" "2102.3" "1855.1" "1351.6" "1629.2" "1749.7" "1589.9" "1613.7" "1809.8" "1665.7" "1990.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "77.407" "25" "12" "25" "12" "505" "54.4" "7.65" "85.67" "12" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.049" "1.105" "1.093" "1.037" "1.092" "1.065" "1.064" "1.280" "1.057" "810.9" "850.6" "896.0" "886.0" "840.7" "885.5" "864.0" "862.7" "1037.8" "857.4" "" "" "" "" "" "" "" "" "" "" "810.9" "719.6" "566.5" "646.0" "688.8" "687.7" "666.0" "741.8" "810.1" "770.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115328096255325213" "False" "High" "IsMasterProtein" "P29966" "Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4" "0.000" "False" "77.314" "30" "7" "16" "7" "332" "31.5" "4.45" "76.53" "7" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "4082" "ENSG00000277443" "MARCKS" "E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Acetylcholine regulates insulin secretion" "2" "0" "0.932" "1.119" "1.061" "0.973" "1.124" "1.150" "0.980" "1.072" "1.091" "959.8" "894.6" "1073.9" "1018.8" "933.9" "1079.3" "1104.0" "940.5" "1028.8" "1047.6" "" "" "" "" "" "" "" "" "" "" "959.8" "756.8" "679.0" "742.8" "765.2" "838.2" "851.0" "808.7" "803.0" "941.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "77.130" "25" "17" "22" "17" "795" "87.1" "6.37" "77.64" "17" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "0.972" "0.881" "0.955" "0.986" "0.933" "0.983" "0.980" "0.894" "0.923" "1586.7" "1542.3" "1397.6" "1515.4" "1564.6" "1480.7" "1559.3" "1554.7" "1418.3" "1465.1" "" "" "" "" "" "" "" "" "" "" "1586.7" "1304.8" "883.7" "1104.9" "1281.9" "1149.9" "1202.0" "1336.7" "1107.1" "1317.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "77.100" "8" "18" "22" "18" "2472" "274.3" "5.52" "70.67" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.049" "0.891" "1.012" "0.997" "1.028" "1.006" "1.004" "0.961" "1.012" "876.1" "918.9" "780.8" "886.5" "873.3" "900.8" "881.8" "879.9" "842.3" "886.2" "" "" "" "" "" "" "" "" "" "" "876.1" "777.4" "493.7" "646.4" "715.5" "699.6" "679.7" "756.5" "657.5" "796.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "77.067" "26" "11" "14" "11" "580" "61.1" "9.01" "57.44" "11" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "1.028" "1.081" "1.005" "1.044" "1.060" "1.007" "1.041" "1.077" "1.044" "1058.1" "1087.5" "1143.9" "1063.6" "1104.7" "1121.8" "1065.5" "1101.2" "1139.8" "1104.9" "" "" "" "" "" "" "" "" "" "" "1058.1" "920.0" "723.3" "775.5" "905.1" "871.2" "821.3" "946.8" "889.7" "993.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "77.004" "21" "13" "21" "13" "710" "80.6" "5.86" "74.89" "13" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "1.019" "1.033" "0.934" "0.962" "0.978" "0.913" "1.008" "0.996" "1.023" "1582.5" "1613.1" "1635.2" "1477.3" "1522.6" "1547.6" "1444.1" "1595.9" "1575.8" "1619.0" "" "" "" "" "" "" "" "" "" "" "1582.5" "1364.7" "1034.0" "1077.2" "1247.5" "1201.8" "1113.2" "1372.1" "1230.0" "1455.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "76.898" "27" "9" "38" "9" "369" "41.3" "5.27" "122.90" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.997" "1.128" "0.981" "0.950" "1.084" "1.008" "0.974" "1.044" "0.972" "2547.7" "2540.7" "2873.6" "2500.2" "2420.5" "2763.0" "2568.4" "2482.4" "2658.7" "2475.8" "" "" "" "" "" "" "" "" "" "" "2547.7" "2149.5" "1817.0" "1823.0" "1983.1" "2145.7" "1979.8" "2134.4" "2075.3" "2225.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5876331061237715446" "False" "High" "IsMasterProtein" "Q14247" "Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2" "0.000" "False" "76.823" "25" "13" "21" "13" "550" "61.5" "5.40" "75.56" "13" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf02218, Pf14604" "2017" "ENSG00000085733; ENSG00000288401" "CTTN" "hsa:2017; Q14247; Q8N707; Q96H99" "Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "Clathrin-mediated endocytosis; RHO GTPases activate PAKs" "6" "0" "0.962" "0.832" "0.962" "0.956" "0.873" "1.011" "0.995" "0.840" "0.936" "1248.3" "1201.4" "1038.6" "1200.5" "1193.1" "1089.8" "1262.0" "1242.0" "1048.7" "1168.0" "" "" "" "" "" "" "" "" "" "" "1248.3" "1016.4" "656.7" "875.4" "977.5" "846.3" "972.8" "1067.9" "818.6" "1050.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "76.713" "17" "13" "35" "13" "825" "90.5" "6.00" "116.83" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.059" "1.019" "0.956" "1.016" "0.997" "0.969" "1.063" "1.011" "1.056" "1925.2" "2038.4" "1961.8" "1839.6" "1955.3" "1919.7" "1865.3" "2046.1" "1946.1" "2033.2" "" "" "" "" "" "" "" "" "" "" "1925.2" "1724.5" "1240.4" "1341.4" "1602.0" "1490.8" "1437.9" "1759.2" "1519.1" "1827.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1518063030880020019" "False" "High" "IsMasterProtein" "P12814" "Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2" "0.000" "False" "76.709" "15" "12" "25" "2" "892" "103.0" "5.41" "81.87" "12" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "87" "ENSG00000072110" "ACTN1" "B3V8S3; B4DHH3; B7TY16; hsa:87; P12814; Q1HE25; Q9BTN1" "Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Ebola virus infection in host; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Regulation of actin cytoskeleton" "RHOD GTPase cycle; RHOF GTPase cycle; Platelet degranulation ; Nephrin family interactions; Syndecan interactions; RHOBTB2 GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "12" "0" "1.028" "1.104" "1.149" "1.089" "1.137" "1.110" "1.079" "1.113" "1.148" "178.6" "183.7" "197.2" "205.3" "194.5" "203.1" "198.3" "192.7" "198.8" "205.0" "" "" "" "" "" "" "" "" "" "" "178.6" "155.4" "124.7" "149.7" "159.3" "157.8" "152.8" "165.7" "155.2" "184.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1392727006884078861" "False" "High" "IsMasterProtein" "P51692" "Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2" "0.000" "False" "76.403" "18" "13" "24" "2" "787" "89.8" "6.05" "84.27" "13" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6777" "ENSG00000173757" "STAT5B" "hsa:6777; P51692; Q8WWS8" "IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; ErbB signaling pathway" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "51" "0" "0.960" "0.780" "0.903" "0.745" "0.820" "0.892" "0.961" "0.808" "1.059" "55.5" "53.2" "43.2" "50.1" "41.3" "45.5" "49.5" "53.3" "44.8" "58.8" "" "" "" "" "" "" "" "" "" "" "55.5" "45.0" "27.3" "36.5" "33.8" "35.3" "38.1" "45.8" "35.0" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "76.369" "27" "13" "30" "13" "505" "55.2" "7.23" "92.65" "13" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "Unfolded protein response" "tRNA processing in the nucleus" "2" "0" "0.982" "0.972" "0.938" "0.975" "1.023" "0.942" "1.009" "0.965" "0.975" "2082.4" "2045.4" "2024.7" "1952.4" "2029.5" "2130.8" "1961.8" "2100.3" "2009.2" "2031.2" "" "" "" "" "" "" "" "" "" "" "2082.4" "1730.5" "1280.2" "1423.6" "1662.8" "1654.7" "1512.2" "1805.8" "1568.3" "1826.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "76.353" "29" "17" "27" "16" "591" "66.6" "6.46" "96.08" "17" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "1" "0.955" "0.918" "0.935" "0.956" "0.923" "0.971" "0.931" "0.924" "0.965" "1572.3" "1502.3" "1443.7" "1470.3" "1503.0" "1451.3" "1526.2" "1463.6" "1452.9" "1517.4" "" "" "" "" "" "" "" "" "" "" "1572.3" "1271.0" "912.9" "1072.0" "1231.4" "1127.0" "1176.5" "1258.4" "1134.1" "1364.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "76.332" "16" "10" "76" "1" "639" "70.0" "5.74" "232.10" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Meiotic synapsis; PKR-mediated signaling; Attenuation phase" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "76.297" "22" "16" "29" "16" "748" "85.4" "6.76" "91.82" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "2" "0" "0.925" "0.936" "0.971" "0.948" "0.956" "0.961" "0.952" "0.947" "0.951" "1542.7" "1427.6" "1443.3" "1497.4" "1462.6" "1474.8" "1483.0" "1468.0" "1460.9" "1467.4" "" "" "" "" "" "" "" "" "" "" "1542.7" "1207.8" "912.6" "1091.8" "1198.3" "1145.3" "1143.2" "1262.2" "1140.4" "1319.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "76.292" "15" "21" "23" "21" "1478" "164.9" "5.22" "71.33" "21" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "2" "0" "0.975" "0.977" "0.982" "1.049" "0.964" "0.987" "0.999" "0.975" "0.990" "1037.2" "1011.1" "1013.8" "1018.5" "1087.9" "999.9" "1024.1" "1036.4" "1011.6" "1027.3" "" "" "" "" "" "" "" "" "" "" "1037.2" "855.5" "641.0" "742.7" "891.4" "776.5" "789.4" "891.1" "789.6" "923.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "76.226" "20" "22" "29" "22" "1056" "119.1" "5.64" "94.82" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "3" "0" "0.977" "0.666" "1.022" "1.007" "0.701" "1.019" "1.013" "0.684" "0.895" "1243.0" "1214.6" "827.7" "1270.4" "1252.3" "870.8" "1267.0" "1259.7" "850.3" "1112.6" "" "" "" "" "" "" "" "" "" "" "1243.0" "1027.6" "523.4" "926.3" "1026.0" "676.3" "976.7" "1083.1" "663.7" "1000.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "76.175" "40" "8" "37" "8" "254" "28.8" "7.18" "138.99" "8" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "8" "0" "1.057" "1.107" "1.041" "0.984" "1.070" "0.920" "0.989" "1.103" "1.031" "2624.0" "2772.5" "2905.4" "2731.8" "2582.0" "2808.0" "2413.4" "2595.2" "2895.2" "2705.0" "" "" "" "" "" "" "" "" "" "" "2624.0" "2345.6" "1837.1" "1991.9" "2115.5" "2180.6" "1860.3" "2231.4" "2259.9" "2432.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "76.090" "25" "13" "27" "13" "562" "61.4" "6.76" "85.48" "13" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Galactose catabolism; Defective PGM1 causes PGM1-CDG" "13" "0" "1.008" "1.136" "1.047" "1.024" "1.070" "0.977" "1.017" "1.097" "1.056" "1093.0" "1101.4" "1241.6" "1144.5" "1119.4" "1169.7" "1068.4" "1111.6" "1199.6" "1154.1" "" "" "" "" "" "" "" "" "" "" "1093.0" "931.8" "785.1" "834.5" "917.1" "908.4" "823.6" "955.8" "936.3" "1037.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "76.070" "26" "11" "26" "9" "471" "54.2" "8.95" "84.58" "11" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "mRNA processing" "" "1" "1" "1.137" "1.087" "1.016" "1.123" "1.162" "1.014" "1.044" "1.162" "1.024" "877.8" "998.3" "954.1" "892.3" "986.2" "1019.8" "890.5" "916.8" "1020.3" "898.5" "" "" "" "" "" "" "" "" "" "" "877.8" "844.6" "603.3" "650.6" "808.0" "792.0" "686.4" "788.3" "796.4" "807.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "75.987" "25" "14" "19" "14" "659" "76.2" "7.77" "71.58" "14" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "FCGR3A-mediated phagocytosis; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "20" "0" "0.949" "0.732" "0.890" "0.887" "0.733" "0.875" "0.973" "0.735" "0.918" "1335.1" "1267.6" "977.7" "1188.9" "1184.7" "978.5" "1167.8" "1299.7" "981.2" "1226.1" "" "" "" "" "" "" "" "" "" "" "1335.1" "1072.4" "618.2" "866.9" "970.6" "759.9" "900.2" "1117.5" "765.9" "1102.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "75.858" "15" "11" "28" "9" "898" "102.3" "4.98" "95.03" "11" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "22q11.2 copy number variation syndrome" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "4" "0" "1.010" "0.878" "0.997" "1.013" "0.896" "1.023" "1.063" "0.908" "1.010" "919.2" "928.3" "807.5" "916.9" "931.5" "823.9" "940.5" "977.4" "835.1" "928.5" "" "" "" "" "" "" "" "" "" "" "919.2" "785.3" "510.6" "668.5" "763.2" "639.8" "725.0" "840.3" "651.8" "834.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "75.388" "28" "12" "37" "12" "408" "46.8" "7.12" "114.52" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "0.993" "0.954" "1.002" "0.999" "0.917" "0.974" "0.992" "0.916" "0.999" "3298.7" "3274.8" "3148.5" "3305.9" "3294.2" "3025.9" "3213.0" "3273.2" "3022.1" "3296.5" "" "" "" "" "" "" "" "" "" "" "3298.7" "2770.6" "1990.8" "2410.5" "2699.0" "2349.8" "2476.7" "2814.3" "2358.9" "2963.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "75.370" "63" "11" "24" "11" "207" "23.5" "6.70" "78.24" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "20" "0" "1.015" "1.176" "1.008" "0.965" "1.191" "1.052" "0.992" "1.139" "1.113" "731.3" "742.2" "860.1" "737.3" "706.0" "870.7" "769.5" "725.3" "832.9" "814.1" "" "" "" "" "" "" "" "" "" "" "731.3" "627.9" "543.9" "537.6" "578.4" "676.2" "593.1" "623.6" "650.2" "732.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "75.255" "54" "15" "25" "15" "315" "36.1" "5.08" "95.91" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "21" "0" "1.023" "0.962" "1.025" "1.011" "0.931" "0.983" "1.017" "0.930" "0.983" "1521.5" "1556.1" "1463.7" "1560.2" "1537.8" "1417.0" "1495.2" "1546.9" "1415.0" "1495.4" "" "" "" "" "" "" "" "" "" "" "1521.5" "1316.5" "925.5" "1137.6" "1259.9" "1100.4" "1152.6" "1330.0" "1104.5" "1344.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "75.171" "18" "14" "24" "14" "912" "102.4" "5.66" "80.01" "14" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOA GTPase cycle; RHOC GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "9" "0" "1.061" "0.904" "1.090" "1.087" "0.932" "1.047" "1.068" "0.969" "1.051" "745.5" "791.2" "674.3" "812.6" "810.4" "694.7" "780.3" "795.9" "722.7" "783.6" "" "" "" "" "" "" "" "" "" "" "745.5" "669.4" "426.3" "592.5" "664.0" "539.5" "601.5" "684.4" "564.1" "704.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "75.170" "25" "17" "28" "17" "689" "78.8" "6.05" "92.61" "17" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.011" "1.061" "1.008" "1.009" "1.032" "0.996" "0.991" "1.024" "1.038" "1983.3" "2005.2" "2104.0" "2000.0" "2001.6" "2046.5" "1975.2" "1965.9" "2030.3" "2059.0" "" "" "" "" "" "" "" "" "" "" "1983.3" "1696.4" "1330.4" "1458.3" "1639.9" "1589.3" "1522.5" "1690.3" "1584.8" "1851.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "75.111" "16" "13" "24" "13" "1038" "119.4" "4.82" "83.34" "13" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "0.923" "0.875" "0.939" "0.905" "0.854" "0.911" "0.945" "0.832" "0.950" "1477.0" "1363.4" "1291.7" "1387.6" "1336.1" "1262.1" "1346.2" "1395.8" "1228.4" "1403.0" "" "" "" "" "" "" "" "" "" "" "1477.0" "1153.4" "816.7" "1011.7" "1094.7" "980.1" "1037.7" "1200.1" "958.8" "1261.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "75.037" "28" "9" "51" "7" "378" "39.6" "9.01" "148.36" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.048" "1.166" "0.974" "1.105" "1.223" "1.044" "1.039" "1.166" "1.111" "1382.3" "1448.1" "1611.2" "1346.2" "1527.7" "1690.1" "1443.2" "1435.6" "1612.4" "1536.1" "" "" "" "" "" "" "" "" "" "" "1382.3" "1225.1" "1018.8" "981.6" "1251.7" "1312.5" "1112.5" "1234.4" "1258.6" "1381.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "74.768" "31" "10" "30" "10" "371" "42.4" "5.35" "93.12" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Extra-nuclear estrogen signaling; Estrogen-dependent gene expression; RMTs methylate histone arginines; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "11" "0" "0.935" "0.987" "0.902" "0.911" "0.918" "0.875" "0.899" "0.950" "0.978" "1310.8" "1226.1" "1293.3" "1182.9" "1194.7" "1203.3" "1147.5" "1178.6" "1245.5" "1282.5" "" "" "" "" "" "" "" "" "" "" "1310.8" "1037.3" "817.7" "862.5" "978.8" "934.5" "884.5" "1013.4" "972.2" "1153.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "74.648" "24" "10" "23" "10" "559" "59.8" "5.29" "81.81" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.948" "1.105" "0.944" "1.009" "1.079" "0.969" "1.026" "1.064" "1.037" "845.8" "801.8" "934.3" "798.5" "853.2" "912.8" "819.2" "867.5" "900.2" "877.2" "" "" "" "" "" "" "" "" "" "" "845.8" "678.4" "590.8" "582.3" "699.0" "708.9" "631.5" "745.9" "702.6" "788.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "73.867" "10" "16" "20" "16" "1845" "204.2" "7.12" "66.14" "16" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "1.000" "1.043" "1.044" "0.977" "1.016" "0.976" "1.019" "1.032" "1.026" "1226.4" "1225.8" "1279.2" "1280.9" "1198.1" "1246.2" "1197.4" "1249.4" "1265.8" "1258.4" "" "" "" "" "" "" "" "" "" "" "1226.4" "1037.1" "808.8" "934.0" "981.6" "967.8" "923.0" "1074.2" "988.1" "1131.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "73.832" "22" "12" "33" "12" "623" "67.8" "7.66" "106.62" "12" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "7" "0" "0.996" "1.042" "1.003" "0.971" "1.042" "0.947" "0.999" "1.052" "1.045" "1343.6" "1338.7" "1400.1" "1347.0" "1304.6" "1400.2" "1272.8" "1341.8" "1414.0" "1403.6" "" "" "" "" "" "" "" "" "" "" "1343.6" "1132.6" "885.3" "982.1" "1068.9" "1087.3" "981.2" "1153.7" "1103.7" "1261.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "73.744" "11" "16" "20" "16" "1849" "206.8" "6.52" "65.89" "16" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "1.016" "0.835" "1.045" "1.015" "0.894" "0.960" "1.003" "0.870" "0.981" "812.9" "826.0" "678.9" "849.5" "825.3" "727.0" "780.0" "815.5" "706.9" "797.6" "" "" "" "" "" "" "" "" "" "" "812.9" "698.8" "429.3" "619.4" "676.1" "564.6" "601.3" "701.1" "551.8" "717.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123184333862718981" "False" "High" "IsMasterProtein" "Q96BY6" "Dedicator of cytokinesis protein 10 OS=Homo sapiens OX=9606 GN=DOCK10 PE=1 SV=3" "0.000" "False" "73.641" "8" "16" "18" "16" "2186" "249.4" "7.14" "59.56" "16" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "55619" "ENSG00000135905" "DOCK10" "B3FL70; hsa:55619; O75178; Q68DA4; Q96BY6; Q9NW06; Q9NXI8" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "5" "0" "1.077" "1.035" "1.087" "1.012" "1.082" "1.048" "1.083" "0.996" "1.067" "783.7" "843.9" "810.8" "852.2" "793.5" "848.2" "821.0" "848.4" "780.8" "836.0" "" "" "" "" "" "" "" "" "" "" "783.7" "714.0" "512.7" "621.4" "650.1" "658.7" "632.9" "729.5" "609.5" "751.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "73.612" "17" "13" "19" "13" "953" "106.3" "8.32" "64.21" "13" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "0.977" "1.477" "1.033" "0.973" "1.449" "0.998" "0.973" "1.461" "1.156" "975.3" "953.0" "1440.7" "1007.0" "948.6" "1413.0" "973.1" "948.8" "1425.2" "1127.7" "" "" "" "" "" "" "" "" "" "" "975.3" "806.2" "911.0" "734.2" "777.2" "1097.3" "750.1" "815.8" "1112.4" "1013.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "73.604" "13" "11" "24" "11" "1087" "114.5" "7.11" "88.26" "11" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.946" "0.988" "0.930" "0.952" "0.960" "0.969" "0.943" "0.985" "0.895" "2329.4" "2204.3" "2302.3" "2166.6" "2217.5" "2236.5" "2257.7" "2197.3" "2295.1" "2084.2" "" "" "" "" "" "" "" "" "" "" "2329.4" "1864.9" "1455.7" "1579.8" "1816.8" "1736.8" "1740.4" "1889.2" "1791.5" "1873.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "73.521" "42" "8" "50" "8" "252" "26.5" "9.36" "176.15" "8" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "Pyrimidine metabolism" "" "1" "0" "1.017" "1.120" "1.106" "1.087" "1.132" "1.120" "1.062" "1.143" "1.140" "1755.0" "1784.0" "1965.3" "1941.5" "1906.9" "1986.0" "1965.2" "1863.1" "2005.5" "2001.0" "" "" "" "" "" "" "" "" "" "" "1755.0" "1509.3" "1242.7" "1415.7" "1562.3" "1542.3" "1514.8" "1601.9" "1565.4" "1799.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "73.514" "39" "10" "35" "10" "294" "32.6" "4.78" "121.65" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "10" "0" "1.081" "1.332" "1.035" "1.145" "1.272" "1.071" "0.985" "1.351" "1.148" "1519.6" "1643.1" "2023.8" "1572.2" "1740.2" "1932.6" "1627.7" "1496.7" "2052.7" "1745.1" "" "" "" "" "" "" "" "" "" "" "1519.6" "1390.1" "1279.7" "1146.4" "1425.7" "1500.8" "1254.7" "1286.9" "1602.3" "1569.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "73.488" "6" "19" "21" "19" "3753" "422.1" "6.83" "68.32" "19" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.056" "0.970" "1.107" "1.020" "0.977" "1.144" "1.076" "0.927" "1.010" "736.0" "776.9" "713.8" "814.6" "750.5" "719.0" "842.2" "792.0" "682.3" "743.1" "" "" "" "" "" "" "" "" "" "" "736.0" "657.3" "451.3" "593.9" "614.9" "558.3" "649.2" "681.0" "532.6" "668.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "73.159" "28" "14" "26" "14" "494" "56.4" "6.96" "80.58" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Regulation of HSF1-mediated heat shock response" "4" "0" "0.948" "0.807" "0.958" "0.989" "0.827" "0.928" "1.033" "0.789" "0.859" "1167.1" "1106.2" "942.1" "1118.2" "1154.5" "965.2" "1083.6" "1205.9" "920.7" "1002.9" "" "" "" "" "" "" "" "" "" "" "1167.1" "935.9" "595.7" "815.3" "945.9" "749.5" "835.2" "1036.8" "718.6" "901.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "73.044" "35" "12" "19" "12" "401" "44.2" "5.21" "70.73" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "0.961" "1.098" "1.185" "1.052" "1.030" "1.085" "1.150" "1.063" "1.175" "378.3" "363.6" "415.4" "448.3" "398.1" "389.6" "410.4" "435.0" "402.1" "444.5" "" "" "" "" "" "" "" "" "" "" "378.3" "307.6" "262.7" "326.8" "326.1" "302.5" "316.4" "374.1" "313.9" "399.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "506200805167063951" "False" "High" "IsMasterProtein" "P42229" "Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1" "0.000" "False" "72.947" "19" "15" "25" "4" "794" "90.6" "6.39" "87.83" "15" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6776" "ENSG00000126561" "STAT5A" "hsa:6776; P42229; Q1KLZ6" "IL-5 signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Puberty (Stage 2 of 4); Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; TYROBP causal network in microglia; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; Interferon type I signaling pathways; ErbB signaling pathway" "Signaling by cytosolic FGFR1 fusion mutants; Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; Nuclear events stimulated by ALK signaling in cancer; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "54" "7" "1.027" "0.834" "0.977" "0.948" "0.797" "0.962" "1.002" "0.830" "0.932" "1709.7" "1756.5" "1425.6" "1670.2" "1621.5" "1362.2" "1645.3" "1713.6" "1419.4" "1593.2" "" "" "" "" "" "" "" "" "" "" "1709.7" "1486.1" "901.4" "1217.8" "1328.5" "1057.9" "1268.3" "1473.3" "1107.9" "1432.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "72.912" "24" "9" "26" "9" "456" "50.1" "6.55" "91.29" "9" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "1.031" "1.157" "1.046" "1.023" "1.082" "1.031" "1.042" "1.077" "1.131" "956.7" "986.1" "1107.0" "1000.9" "978.5" "1035.3" "986.6" "997.1" "1030.6" "1081.6" "" "" "" "" "" "" "" "" "" "" "956.7" "834.3" "700.0" "729.8" "801.7" "804.0" "760.5" "857.3" "804.5" "972.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "72.821" "41" "10" "35" "10" "261" "28.8" "4.69" "126.35" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "47" "0" "0.998" "1.108" "0.980" "0.965" "1.003" "0.919" "0.991" "1.033" "1.017" "3061.0" "3056.3" "3392.8" "2999.5" "2953.9" "3071.0" "2812.5" "3034.3" "3162.5" "3112.0" "" "" "" "" "" "" "" "" "" "" "3061.0" "2585.7" "2145.3" "2187.0" "2420.1" "2384.9" "2168.0" "2608.9" "2468.5" "2797.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3370309329751245495" "False" "High" "IsMasterProtein" "Q96RQ9" "L-amino-acid oxidase OS=Homo sapiens OX=9606 GN=IL4I1 PE=1 SV=1" "0.000" "False" "72.804" "25" "13" "35" "13" "567" "62.8" "8.68" "92.89" "13" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01593" "259307" "ENSG00000104951" "IL4I1" "hsa:259307; Q1WMJ3; Q4GZN1; Q4GZN2; Q6P2Q3; Q8TEM5; Q96RQ8; Q96RQ9" "Methionine de novo and salvage pathway" "Phenylalanine metabolism" "2" "0" "1.013" "0.988" "1.004" "1.046" "0.996" "1.061" "0.997" "0.957" "0.987" "1804.8" "1827.7" "1782.8" "1812.7" "1888.5" "1798.2" "1914.9" "1799.1" "1726.7" "1781.8" "" "" "" "" "" "" "" "" "" "" "1804.8" "1546.3" "1127.3" "1321.8" "1547.3" "1396.4" "1476.1" "1546.8" "1347.8" "1601.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "72.751" "21" "14" "25" "14" "747" "85.1" "4.91" "76.28" "14" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "1.073" "1.151" "1.015" "1.038" "1.137" "1.061" "1.116" "1.189" "1.085" "1582.6" "1698.7" "1822.3" "1605.9" "1642.4" "1798.9" "1678.7" "1765.8" "1881.6" "1716.7" "" "" "" "" "" "" "" "" "" "" "1582.6" "1437.2" "1152.3" "1171.0" "1345.6" "1397.0" "1294.0" "1518.2" "1468.7" "1543.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "72.479" "17" "17" "21" "17" "1030" "115.2" "5.40" "75.01" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "1.069" "1.083" "1.109" "1.101" "1.168" "1.115" "1.080" "1.115" "1.052" "1344.1" "1436.9" "1455.3" "1491.0" "1479.7" "1569.9" "1498.5" "1452.3" "1498.7" "1414.4" "" "" "" "" "" "" "" "" "" "" "1344.1" "1215.6" "920.2" "1087.2" "1212.3" "1219.1" "1155.1" "1248.7" "1169.8" "1271.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "72.430" "15" "16" "22" "16" "1204" "136.2" "5.80" "72.15" "16" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "MicroRNA (miRNA) biogenesis" "4" "0" "1.073" "0.957" "1.021" "1.021" "0.948" "1.020" "1.071" "0.906" "1.011" "1049.6" "1125.7" "1004.4" "1071.5" "1071.3" "994.8" "1070.4" "1124.6" "950.9" "1060.9" "" "" "" "" "" "" "" "" "" "" "1049.6" "952.3" "635.1" "781.3" "877.7" "772.6" "825.1" "966.9" "742.3" "953.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "72.272" "24" "11" "22" "11" "527" "58.0" "6.43" "86.97" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "1.029" "0.869" "1.076" "1.029" "0.881" "1.021" "1.030" "0.877" "0.995" "818.9" "842.6" "712.0" "881.0" "842.4" "721.3" "835.9" "843.4" "718.2" "814.8" "" "" "" "" "" "" "" "" "" "" "818.9" "712.9" "450.2" "642.4" "690.2" "560.1" "644.4" "725.1" "560.6" "732.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "72.084" "13" "17" "24" "17" "1278" "141.6" "5.81" "73.53" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Signaling by ALK fusions and activated point mutants; XBP1(S) activates chaperone genes" "8" "0" "1.059" "1.035" "1.083" "1.028" "1.004" "1.052" "1.047" "1.003" "0.977" "889.6" "942.3" "920.6" "963.7" "914.6" "893.1" "936.1" "931.0" "891.8" "869.4" "" "" "" "" "" "" "" "" "" "" "889.6" "797.2" "582.1" "702.7" "749.4" "693.6" "721.6" "800.5" "696.1" "781.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "71.902" "8" "15" "18" "15" "2285" "241.9" "6.70" "64.29" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "0" "1.057" "1.093" "1.051" "1.133" "1.074" "1.097" "1.144" "0.993" "1.029" "673.5" "711.8" "736.4" "707.8" "763.0" "723.0" "738.9" "770.2" "668.8" "692.7" "" "" "" "" "" "" "" "" "" "" "673.5" "602.2" "465.6" "516.1" "625.2" "561.5" "569.6" "662.2" "522.1" "622.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "71.564" "16" "16" "26" "5" "949" "104.5" "5.06" "86.29" "16" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "9" "1.094" "1.074" "1.025" "1.048" "1.105" "1.055" "1.061" "1.071" "1.053" "1416.6" "1549.4" "1521.0" "1452.4" "1484.5" "1564.8" "1494.5" "1503.6" "1517.2" "1491.5" "" "" "" "" "" "" "" "" "" "" "1416.6" "1310.9" "961.7" "1059.0" "1216.2" "1215.2" "1152.0" "1292.8" "1184.3" "1340.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "71.224" "27" "12" "21" "12" "488" "52.7" "5.68" "69.75" "12" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.087" "1.086" "1.004" "0.968" "1.084" "0.987" "1.040" "1.065" "1.037" "602.5" "654.8" "654.5" "604.8" "583.0" "653.0" "594.8" "626.8" "641.9" "624.5" "" "" "" "" "" "" "" "" "" "" "602.5" "554.0" "413.8" "441.0" "477.6" "507.1" "458.5" "538.9" "501.0" "561.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "71.126" "24" "10" "22" "10" "524" "59.0" "7.34" "74.83" "10" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "0.985" "1.008" "0.939" "0.944" "1.039" "0.920" "0.999" "1.008" "0.973" "1036.7" "1020.8" "1045.5" "973.6" "978.9" "1077.1" "954.2" "1035.2" "1044.8" "1009.0" "" "" "" "" "" "" "" "" "" "" "1036.7" "863.7" "661.1" "709.9" "802.0" "836.4" "735.6" "890.1" "815.5" "907.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "70.937" "29" "15" "29" "15" "515" "59.2" "6.84" "87.93" "15" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "16" "0" "1.008" "1.007" "0.977" "0.991" "1.023" "0.939" "0.974" "1.016" "1.030" "1335.4" "1346.0" "1345.1" "1305.1" "1323.4" "1366.4" "1254.4" "1300.9" "1357.1" "1375.3" "" "" "" "" "" "" "" "" "" "" "1335.4" "1138.8" "850.5" "951.6" "1084.3" "1061.1" "966.9" "1118.5" "1059.3" "1236.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.000" "False" "70.755" "29" "12" "22" "12" "435" "49.9" "6.27" "73.57" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Insulin receptor recycling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "14" "0" "0.995" "0.872" "0.912" "0.943" "0.806" "0.962" "0.997" "0.793" "0.905" "1497.6" "1490.2" "1305.8" "1365.9" "1411.5" "1206.4" "1440.1" "1493.2" "1187.7" "1355.7" "" "" "" "" "" "" "" "" "" "" "1497.6" "1260.7" "825.6" "995.9" "1156.5" "936.9" "1110.1" "1283.9" "927.1" "1218.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "70.438" "37" "15" "27" "15" "389" "45.5" "5.62" "88.63" "15" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ABC-family proteins mediated transport; Neutrophil degranulation; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.039" "0.987" "1.050" "1.021" "0.989" "1.063" "1.100" "1.000" "0.980" "2093.1" "2175.1" "2065.9" "2198.7" "2137.4" "2070.8" "2224.4" "2303.1" "2092.9" "2052.0" "" "" "" "" "" "" "" "" "" "" "2093.1" "1840.2" "1306.3" "1603.1" "1751.2" "1608.1" "1714.7" "1980.2" "1633.6" "1844.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "70.430" "34" "8" "44" "7" "391" "45.3" "4.46" "169.37" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "0.934" "1.008" "0.983" "1.016" "0.971" "0.979" "0.991" "0.952" "1.004" "1667.4" "1557.8" "1680.3" "1638.7" "1693.8" "1619.3" "1632.6" "1651.9" "1587.2" "1674.9" "" "" "" "" "" "" "" "" "" "" "1667.4" "1317.9" "1062.5" "1194.8" "1387.7" "1257.5" "1258.4" "1420.3" "1238.9" "1505.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "70.344" "28" "8" "24" "8" "328" "35.6" "7.39" "80.67" "8" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.022" "1.062" "0.948" "1.034" "1.063" "0.998" "1.075" "1.054" "1.079" "1052.9" "1076.5" "1117.9" "998.1" "1088.8" "1119.2" "1051.4" "1132.0" "1109.6" "1136.6" "" "" "" "" "" "" "" "" "" "" "1052.9" "910.8" "706.9" "727.8" "892.0" "869.2" "810.4" "973.3" "866.1" "1021.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "70.321" "32" "7" "30" "5" "324" "35.9" "9.88" "114.82" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Noncanonical activation of NOTCH3" "10" "0" "1.068" "1.186" "1.021" "1.060" "1.078" "1.014" "0.916" "1.059" "1.173" "916.9" "978.8" "1087.3" "936.3" "972.0" "988.6" "929.3" "839.6" "970.7" "1075.0" "" "" "" "" "" "" "" "" "" "" "916.9" "828.1" "687.5" "682.7" "796.3" "767.7" "716.3" "721.9" "757.7" "966.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "70.222" "15" "13" "20" "8" "915" "102.6" "5.47" "70.37" "13" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "Interleukin-1 (IL-1) structural pathway" "SUMOylation of transcription cofactors" "2" "5" "1.047" "1.383" "1.061" "1.123" "1.439" "1.087" "1.098" "1.418" "1.152" "816.9" "855.5" "1129.4" "866.7" "917.6" "1175.9" "887.7" "897.1" "1158.3" "941.1" "" "" "" "" "" "" "" "" "" "" "816.9" "723.7" "714.2" "631.9" "751.8" "913.2" "684.3" "771.3" "904.1" "846.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "70.159" "25" "14" "19" "14" "617" "71.3" "5.72" "70.73" "14" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "" "Clathrin-mediated endocytosis; CDC42 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "5" "0" "0.982" "1.101" "0.991" "0.938" "1.009" "0.952" "0.969" "1.025" "0.959" "1602.2" "1573.5" "1764.2" "1587.3" "1503.6" "1616.1" "1525.0" "1552.0" "1641.6" "1536.1" "" "" "" "" "" "" "" "" "" "" "1602.2" "1331.2" "1115.5" "1157.4" "1231.9" "1255.1" "1175.5" "1334.4" "1281.4" "1381.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "70.093" "30" "10" "34" "8" "434" "47.2" "5.03" "137.11" "10" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "0" "1.020" "1.082" "1.151" "1.040" "1.057" "0.992" "1.053" "1.453" "1.119" "610.2" "622.6" "660.0" "702.2" "634.5" "644.7" "605.1" "642.8" "886.4" "682.6" "" "" "" "" "" "" "" "" "" "" "610.2" "526.7" "417.3" "512.0" "519.8" "500.7" "466.4" "552.7" "691.9" "613.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "70.002" "20" "12" "19" "12" "661" "75.0" "6.37" "63.39" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.989" "0.926" "0.969" "0.975" "1.002" "0.959" "1.033" "0.971" "1.017" "1291.7" "1278.0" "1196.2" "1252.1" "1258.9" "1294.1" "1238.9" "1334.3" "1254.0" "1314.3" "" "" "" "" "" "" "" "" "" "" "1291.7" "1081.2" "756.3" "913.0" "1031.5" "1005.0" "955.0" "1147.2" "978.8" "1181.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "69.978" "37" "10" "37" "6" "365" "38.6" "6.79" "114.67" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "7" "0" "1.031" "0.832" "1.035" "0.994" "0.844" "1.057" "1.008" "0.857" "0.983" "971.0" "1001.2" "808.3" "1005.4" "964.9" "819.6" "1026.5" "978.9" "832.4" "954.8" "" "" "" "" "" "" "" "" "" "" "971.0" "847.0" "511.1" "733.0" "790.6" "636.5" "791.3" "841.7" "649.8" "858.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.000" "False" "69.968" "18" "15" "19" "15" "946" "105.0" "6.34" "67.12" "15" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "Clock-controlled autophagy in bone metabolism" "RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "4" "0" "1.030" "0.786" "1.040" "1.049" "0.791" "1.007" "1.084" "0.794" "0.975" "675.8" "695.8" "531.0" "702.5" "709.0" "534.8" "680.6" "732.4" "536.3" "658.7" "" "" "" "" "" "" "" "" "" "" "675.8" "588.7" "335.8" "512.2" "580.9" "415.3" "524.6" "629.7" "418.6" "592.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "High" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.000" "False" "69.821" "5" "13" "19" "13" "3142" "347.4" "6.20" "60.66" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "Regulation of MECP2 expression and activity" "7" "0" "1.076" "0.902" "1.061" "1.095" "0.916" "0.993" "1.060" "0.908" "1.077" "719.5" "774.2" "649.2" "763.5" "787.6" "658.8" "714.7" "762.4" "653.6" "774.6" "" "" "" "" "" "" "" "" "" "" "719.5" "655.0" "410.5" "556.7" "645.3" "511.6" "550.9" "655.5" "510.2" "696.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "69.808" "20" "11" "21" "11" "616" "68.1" "7.21" "72.07" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "0.978" "0.990" "0.986" "0.974" "0.985" "0.996" "0.978" "0.999" "0.976" "1665.7" "1628.2" "1649.3" "1641.8" "1621.7" "1639.9" "1659.7" "1629.5" "1663.8" "1625.9" "" "" "" "" "" "" "" "" "" "" "1665.7" "1377.5" "1042.8" "1197.1" "1328.6" "1273.5" "1279.4" "1401.0" "1298.7" "1461.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "69.760" "13" "19" "20" "17" "1575" "180.5" "5.64" "66.73" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Ciliary landscape; G13 signaling pathway" "Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate IQGAPs" "7" "0" "1.050" "0.887" "1.091" "1.050" "0.888" "1.024" "1.070" "0.862" "0.948" "1034.3" "1086.2" "917.2" "1128.4" "1085.6" "918.1" "1059.0" "1106.3" "891.6" "980.4" "" "" "" "" "" "" "" "" "" "" "1034.3" "918.9" "580.0" "822.8" "889.5" "713.0" "816.3" "951.2" "695.9" "881.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "69.565" "46" "11" "23" "11" "276" "30.6" "7.21" "68.82" "11" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "" "Neutrophil degranulation" "1" "0" "0.910" "1.029" "0.897" "0.899" "0.993" "0.865" "0.916" "1.005" "0.991" "1817.4" "1654.5" "1869.4" "1631.1" "1634.5" "1805.5" "1571.7" "1664.1" "1826.3" "1801.9" "" "" "" "" "" "" "" "" "" "" "1817.4" "1399.7" "1182.0" "1189.3" "1339.1" "1402.1" "1211.5" "1430.8" "1425.5" "1620.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "69.374" "39" "8" "25" "8" "261" "29.0" "7.31" "85.33" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "0.938" "1.042" "0.908" "0.974" "1.053" "0.970" "0.937" "0.974" "0.976" "1959.5" "1837.6" "2041.9" "1779.0" "1908.8" "2062.7" "1901.7" "1836.8" "1909.1" "1911.7" "" "" "" "" "" "" "" "" "" "" "1959.5" "1554.7" "1291.1" "1297.2" "1563.9" "1601.9" "1465.9" "1579.3" "1490.2" "1718.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "69.319" "29" "14" "18" "14" "546" "61.9" "6.52" "73.28" "14" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "" "Other interleukin signaling" "1" "0" "0.991" "0.853" "1.030" "1.033" "0.931" "1.113" "1.037" "0.917" "0.968" "1410.7" "1398.0" "1203.1" "1453.2" "1457.5" "1313.1" "1569.5" "1462.9" "1294.1" "1365.3" "" "" "" "" "" "" "" "" "" "" "1410.7" "1182.8" "760.7" "1059.6" "1194.1" "1019.7" "1209.8" "1257.8" "1010.2" "1227.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "69.186" "20" "15" "18" "10" "759" "87.6" "8.13" "61.18" "15" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of Incision Complex in GG-NER; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "0" "1.076" "1.059" "1.075" "0.993" "1.052" "1.031" "1.091" "1.063" "1.106" "431.1" "464.1" "456.7" "463.3" "428.0" "453.4" "444.3" "470.5" "458.1" "476.7" "" "" "" "" "" "" "" "" "" "" "431.1" "392.6" "288.8" "337.8" "350.6" "352.1" "342.5" "404.6" "357.6" "428.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "69.110" "31" "14" "31" "13" "419" "48.1" "6.68" "100.67" "14" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "1" "1.040" "1.084" "1.039" "0.996" "1.037" "0.997" "1.005" "1.049" "1.018" "2095.0" "2178.3" "2271.9" "2177.0" "2087.1" "2172.6" "2089.3" "2105.5" "2197.4" "2132.1" "" "" "" "" "" "" "" "" "" "" "2095.0" "1842.9" "1436.5" "1587.4" "1710.0" "1687.2" "1610.5" "1810.3" "1715.2" "1916.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "69.107" "25" "8" "18" "8" "433" "45.5" "8.69" "69.97" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "" "tRNA processing in the nucleus" "1" "0" "1.062" "0.997" "1.025" "1.090" "1.029" "1.028" "1.043" "0.995" "1.094" "624.1" "662.8" "622.6" "639.7" "680.2" "642.0" "641.3" "651.1" "621.1" "682.9" "" "" "" "" "" "" "" "" "" "" "624.1" "560.7" "393.7" "466.4" "557.3" "498.6" "494.4" "559.8" "484.8" "614.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "69.034" "16" "12" "32" "12" "732" "82.7" "5.81" "107.23" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.976" "0.944" "0.994" "1.012" "0.938" "0.975" "0.976" "0.961" "0.991" "1058.6" "1033.1" "999.3" "1051.9" "1071.7" "992.8" "1032.6" "1033.4" "1017.9" "1048.8" "" "" "" "" "" "" "" "" "" "" "1058.6" "874.0" "631.9" "767.0" "878.1" "771.0" "796.0" "888.5" "794.5" "942.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "69.005" "8" "19" "28" "19" "2335" "273.4" "8.84" "80.15" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.056" "0.988" "1.128" "1.040" "1.038" "1.083" "1.081" "1.008" "1.028" "707.6" "746.9" "699.4" "798.1" "736.0" "734.2" "766.2" "765.0" "713.4" "727.5" "" "" "" "" "" "" "" "" "" "" "707.6" "631.9" "442.2" "581.9" "603.0" "570.2" "590.6" "657.7" "556.9" "654.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "68.632" "11" "15" "20" "8" "1590" "181.2" "7.20" "62.66" "15" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "8" "0" "1.126" "0.935" "0.974" "1.053" "0.950" "1.083" "1.050" "0.794" "0.982" "359.9" "405.1" "336.4" "350.5" "379.2" "341.9" "389.7" "377.8" "285.8" "353.5" "" "" "" "" "" "" "" "" "" "" "359.9" "342.7" "212.7" "255.6" "310.6" "265.5" "300.4" "324.8" "223.1" "317.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "68.478" "13" "16" "25" "16" "1338" "144.6" "5.76" "79.19" "16" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "1.057" "1.064" "1.090" "1.076" "1.059" "1.055" "1.060" "1.140" "1.109" "1130.5" "1194.8" "1202.5" "1232.4" "1216.6" "1197.6" "1192.6" "1198.6" "1288.8" "1253.9" "" "" "" "" "" "" "" "" "" "" "1130.5" "1010.8" "760.4" "898.6" "996.7" "930.0" "919.3" "1030.6" "1006.0" "1127.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "68.475" "40" "12" "52" "8" "248" "28.5" "4.69" "174.00" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Striated muscle contraction pathway" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "5" "1" "1.004" "1.113" "1.056" "1.016" "1.126" "1.163" "1.029" "1.135" "1.056" "2072.5" "2081.3" "2307.0" "2189.1" "2106.3" "2334.7" "2411.3" "2132.4" "2351.5" "2189.0" "" "" "" "" "" "" "" "" "" "" "2072.5" "1760.8" "1458.7" "1596.2" "1725.7" "1813.1" "1858.7" "1833.4" "1835.5" "1968.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "68.384" "15" "16" "27" "16" "1098" "123.8" "8.65" "78.51" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.072" "1.027" "1.079" "1.084" "1.120" "1.090" "1.083" "1.023" "1.033" "1462.3" "1567.8" "1501.6" "1577.4" "1585.8" "1638.1" "1593.3" "1584.3" "1496.0" "1510.0" "" "" "" "" "" "" "" "" "" "" "1462.3" "1326.4" "949.5" "1150.2" "1299.2" "1272.1" "1228.1" "1362.2" "1167.7" "1357.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "68.312" "41" "8" "102" "8" "165" "18.0" "7.81" "275.79" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Prolactin signaling pathway" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "16" "0" "1.016" "1.057" "1.000" "1.003" "1.000" "0.982" "0.999" "1.023" "1.033" "5817.1" "5908.6" "6146.9" "5816.8" "5832.1" "5814.4" "5715.1" "5813.0" "5950.1" "6007.8" "" "" "" "" "" "" "" "" "" "" "5817.1" "4998.8" "3886.7" "4241.3" "4778.3" "4515.3" "4405.4" "4998.0" "4644.5" "5401.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "68.289" "25" "12" "23" "12" "609" "67.3" "6.57" "68.96" "12" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "Phosphodiesterases in neuronal function" "OAS antiviral response" "2" "0" "1.036" "0.998" "0.998" "1.014" "0.955" "0.986" "0.995" "0.993" "0.932" "793.3" "821.5" "791.5" "791.5" "804.7" "757.9" "781.9" "789.7" "787.5" "739.7" "" "" "" "" "" "" "" "" "" "" "793.3" "695.0" "500.5" "577.1" "659.3" "588.6" "602.7" "679.0" "614.7" "665.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "67.969" "35" "12" "30" "12" "337" "37.5" "6.81" "95.04" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "9" "0" "1.008" "1.102" "1.011" "1.019" "1.059" "1.007" "1.010" "1.082" "1.082" "2216.3" "2234.6" "2443.0" "2240.4" "2258.9" "2347.1" "2231.3" "2237.9" "2399.0" "2398.4" "" "" "" "" "" "" "" "" "" "" "2216.3" "1890.5" "1544.7" "1633.6" "1850.8" "1822.7" "1720.0" "1924.1" "1872.6" "2156.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "67.818" "32" "12" "22" "12" "434" "47.0" "5.44" "77.75" "12" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "6" "0" "1.023" "1.035" "1.048" "1.008" "0.971" "0.996" "0.989" "1.052" "1.013" "981.3" "1004.3" "1016.0" "1028.8" "989.4" "953.0" "977.4" "970.2" "1032.5" "993.6" "" "" "" "" "" "" "" "" "" "" "981.3" "849.6" "642.4" "750.1" "810.6" "740.1" "753.4" "834.2" "805.9" "893.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "67.700" "8" "15" "20" "15" "2157" "243.2" "8.75" "59.82" "15" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Vitamin D receptor pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "10" "0" "1.028" "0.816" "0.992" "1.058" "0.882" "1.071" "1.128" "0.880" "1.038" "818.3" "841.0" "667.9" "811.6" "866.1" "721.6" "876.7" "923.3" "719.8" "849.8" "" "" "" "" "" "" "" "" "" "" "818.3" "711.5" "422.3" "591.8" "709.6" "560.4" "675.8" "793.9" "561.9" "764.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "67.575" "19" "15" "33" "15" "795" "87.2" "7.12" "99.84" "15" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Amino acid metabolism" "Mitochondrial protein degradation" "2" "0" "1.031" "1.040" "0.987" "1.061" "1.020" "1.047" "1.018" "1.040" "1.028" "1563.7" "1612.2" "1625.8" "1543.6" "1659.7" "1595.7" "1637.9" "1591.2" "1626.5" "1607.9" "" "" "" "" "" "" "" "" "" "" "1563.7" "1364.0" "1028.0" "1125.5" "1359.8" "1239.2" "1262.5" "1368.1" "1269.6" "1445.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "67.516" "14" "18" "21" "18" "1274" "141.1" "6.13" "66.11" "18" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.019" "0.993" "0.965" "1.025" "0.943" "0.978" "1.034" "0.999" "0.995" "1041.6" "1061.7" "1034.4" "1005.5" "1067.8" "982.4" "1018.8" "1076.8" "1040.4" "1036.8" "" "" "" "" "" "" "" "" "" "" "1041.6" "898.2" "654.1" "733.1" "874.8" "762.9" "785.4" "925.8" "812.1" "932.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "67.501" "20" "16" "26" "11" "727" "83.8" "6.28" "77.33" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Chemokine signaling pathway; CCL18 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "7" "2" "1.017" "0.993" "1.026" "0.998" "1.001" "0.964" "1.014" "0.991" "0.908" "1617.3" "1645.2" "1605.6" "1659.0" "1614.0" "1619.0" "1559.4" "1640.3" "1602.5" "1469.2" "" "" "" "" "" "" "" "" "" "" "1617.3" "1391.9" "1015.2" "1209.7" "1322.4" "1257.3" "1202.0" "1410.4" "1250.8" "1320.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "67.487" "17" "15" "26" "15" "870" "98.0" "7.44" "76.59" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "14" "0" "1.067" "0.996" "1.052" "1.048" "0.985" "1.108" "1.044" "0.974" "1.042" "1343.9" "1433.5" "1338.0" "1414.0" "1408.6" "1323.4" "1488.9" "1402.6" "1309.5" "1400.6" "" "" "" "" "" "" "" "" "" "" "1343.9" "1212.8" "846.0" "1031.0" "1154.1" "1027.7" "1147.7" "1205.9" "1022.1" "1259.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "67.442" "12" "16" "20" "16" "1328" "149.2" "6.74" "68.76" "16" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "5" "0" "0.996" "0.667" "0.972" "1.029" "0.698" "0.954" "0.990" "0.695" "0.871" "1855.5" "1848.7" "1236.9" "1802.6" "1908.9" "1294.5" "1770.4" "1837.2" "1289.6" "1615.5" "" "" "" "" "" "" "" "" "" "" "1855.5" "1564.1" "782.1" "1314.4" "1564.0" "1005.3" "1364.7" "1579.6" "1006.6" "1452.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "67.366" "16" "14" "24" "14" "876" "100.6" "5.96" "75.85" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "2" "0" "0.996" "1.115" "1.042" "1.030" "1.076" "1.057" "1.016" "1.073" "1.022" "2015.9" "2007.9" "2247.1" "2099.8" "2076.4" "2169.6" "2130.8" "2048.1" "2164.0" "2060.8" "" "" "" "" "" "" "" "" "" "" "2015.9" "1698.7" "1420.8" "1531.0" "1701.2" "1684.9" "1642.5" "1760.9" "1689.1" "1852.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "67.313" "43" "9" "30" "9" "248" "27.9" "8.46" "97.97" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.060" "1.018" "0.954" "0.998" "1.055" "0.981" "0.948" "1.040" "1.041" "2134.7" "2263.4" "2172.6" "2035.9" "2130.1" "2251.6" "2093.6" "2023.9" "2221.0" "2222.2" "" "" "" "" "" "" "" "" "" "" "2134.7" "1914.9" "1373.8" "1484.5" "1745.2" "1748.5" "1613.8" "1740.2" "1733.6" "1997.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "67.191" "18" "19" "27" "19" "1052" "121.8" "8.09" "84.89" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "10q11.21q11.23 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "5" "0" "1.022" "0.935" "0.998" "1.061" "0.950" "1.013" "1.014" "0.904" "0.972" "1424.7" "1456.1" "1331.6" "1421.6" "1511.8" "1353.1" "1443.9" "1445.1" "1288.6" "1385.4" "" "" "" "" "" "" "" "" "" "" "1424.7" "1231.9" "842.0" "1036.6" "1238.6" "1050.8" "1113.0" "1242.5" "1005.8" "1245.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "67.167" "25" "8" "19" "8" "328" "35.8" "8.00" "63.80" "8" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Fatty acid biosynthesis; IL-18 signaling pathway" "Peroxisomal protein import; Mitochondrial protein degradation" "4" "0" "1.133" "1.186" "0.979" "1.054" "1.071" "0.948" "1.045" "1.134" "1.123" "842.0" "953.9" "998.4" "824.4" "887.7" "902.0" "798.6" "879.8" "954.6" "945.8" "" "" "" "" "" "" "" "" "" "" "842.0" "807.1" "631.3" "601.1" "727.3" "700.5" "615.6" "756.4" "745.1" "850.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "67.133" "24" "13" "18" "13" "607" "66.3" "5.31" "56.62" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "2" "0" "0.929" "0.859" "1.001" "0.973" "0.899" "0.986" "0.935" "0.844" "1.009" "604.3" "561.6" "519.2" "604.9" "587.7" "543.4" "596.0" "565.0" "510.1" "609.7" "" "" "" "" "" "" "" "" "" "" "604.3" "475.1" "328.3" "441.1" "481.5" "422.0" "459.4" "485.7" "398.2" "548.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "67.133" "44" "8" "35" "7" "225" "24.7" "4.67" "126.62" "8" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.970" "1.166" "1.016" "0.989" "1.205" "1.028" "1.027" "1.194" "1.151" "1583.0" "1535.9" "1845.2" "1608.4" "1566.2" "1907.8" "1627.8" "1626.0" "1889.7" "1821.8" "" "" "" "" "" "" "" "" "" "" "1583.0" "1299.4" "1166.7" "1172.7" "1283.2" "1481.5" "1254.7" "1398.0" "1475.1" "1637.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "67.035" "19" "8" "22" "6" "524" "58.0" "5.96" "66.58" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; RHOV GTPase cycle; Smooth Muscle Contraction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Ephrin signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "45" "1" "0.977" "0.852" "0.992" "0.966" "0.854" "0.971" "1.005" "0.902" "0.973" "921.7" "900.5" "785.3" "914.4" "890.5" "787.4" "894.9" "926.6" "831.5" "897.0" "" "" "" "" "" "" "" "" "" "" "921.7" "761.8" "496.5" "666.8" "729.6" "611.5" "689.8" "796.7" "649.0" "806.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "67.021" "31" "9" "22" "9" "330" "37.4" "10.01" "71.54" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "1.029" "0.975" "0.961" "1.071" "0.993" "1.063" "1.069" "0.945" "0.970" "1772.1" "1823.9" "1727.1" "1703.6" "1897.9" "1759.9" "1883.9" "1893.5" "1675.3" "1719.3" "" "" "" "" "" "" "" "" "" "" "1772.1" "1543.1" "1092.1" "1242.2" "1555.0" "1366.7" "1452.2" "1628.0" "1307.6" "1545.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "66.992" "19" "14" "20" "14" "751" "83.4" "7.01" "65.14" "14" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "" "Mitochondrial translation elongation" "1" "0" "1.052" "0.952" "1.000" "0.956" "0.970" "0.941" "1.041" "0.899" "1.024" "1066.4" "1121.8" "1015.5" "1066.1" "1019.4" "1034.4" "1003.2" "1110.6" "958.2" "1092.5" "" "" "" "" "" "" "" "" "" "" "1066.4" "949.1" "642.1" "777.4" "835.2" "803.3" "773.3" "954.9" "748.0" "982.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "66.977" "22" "15" "24" "15" "740" "82.4" "7.23" "76.55" "15" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "tRNA processing in the nucleus" "3" "0" "1.201" "0.952" "1.047" "1.031" "1.079" "0.991" "0.962" "1.087" "1.052" "1076.5" "1293.2" "1025.0" "1126.8" "1110.3" "1161.2" "1066.5" "1035.7" "1170.4" "1132.2" "" "" "" "" "" "" "" "" "" "" "1076.5" "1094.1" "648.1" "821.6" "909.7" "901.8" "822.1" "890.5" "913.6" "1017.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "66.770" "18" "15" "19" "15" "958" "108.9" "7.14" "63.03" "15" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.042" "0.877" "0.981" "1.001" "0.888" "0.979" "1.030" "0.858" "1.028" "721.5" "751.7" "632.7" "707.5" "722.2" "640.9" "706.1" "743.2" "618.7" "742.0" "" "" "" "" "" "" "" "" "" "" "721.5" "636.0" "400.1" "515.9" "591.7" "497.7" "544.3" "639.0" "482.9" "667.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "66.704" "9" "12" "18" "12" "1761" "191.5" "7.18" "57.32" "12" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "Thermogenesis" "HDMs demethylate histones" "2" "0" "1.051" "0.883" "1.017" "1.014" "0.892" "1.084" "1.110" "0.863" "0.969" "800.7" "841.9" "707.2" "814.0" "811.6" "714.4" "867.8" "888.8" "691.2" "775.6" "" "" "" "" "" "" "" "" "" "" "800.7" "712.3" "447.2" "593.5" "665.0" "554.8" "668.9" "764.2" "539.5" "697.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "66.670" "40" "8" "15" "8" "271" "31.3" "4.94" "64.39" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "" "Ub-specific processing proteases; Ovarian tumor domain proteases" "2" "0" "1.009" "1.235" "0.985" "1.038" "1.082" "1.020" "1.121" "1.161" "1.216" "556.7" "562.0" "687.7" "548.2" "577.9" "602.2" "567.8" "624.0" "646.6" "676.8" "" "" "" "" "" "" "" "" "" "" "556.7" "475.5" "434.8" "399.7" "473.5" "467.6" "437.7" "536.6" "504.7" "608.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "66.649" "13" "9" "18" "9" "704" "80.6" "6.64" "65.89" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "" "Peptide ligand-binding receptors" "1" "0" "0.981" "1.042" "0.978" "0.978" "1.000" "0.958" "0.975" "1.022" "1.094" "1557.8" "1527.6" "1622.7" "1523.7" "1523.1" "1557.6" "1492.5" "1518.5" "1591.5" "1704.7" "" "" "" "" "" "" "" "" "" "" "1557.8" "1292.4" "1026.0" "1111.0" "1247.9" "1209.6" "1150.4" "1305.6" "1242.2" "1532.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "66.541" "15" "15" "24" "14" "1075" "113.3" "8.59" "82.17" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "16p11.2 distal deletion syndrome" "" "1" "1" "0.967" "0.967" "0.952" "0.988" "1.004" "0.957" "0.997" "1.035" "1.002" "1293.4" "1251.2" "1251.1" "1231.2" "1278.5" "1298.5" "1238.2" "1289.0" "1338.7" "1296.6" "" "" "" "" "" "" "" "" "" "" "1293.4" "1058.5" "791.1" "897.7" "1047.5" "1008.4" "954.4" "1108.3" "1045.0" "1165.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "66.474" "16" "16" "23" "16" "1041" "115.9" "4.81" "69.40" "16" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.015" "0.958" "0.978" "1.003" "0.990" "0.995" "1.047" "0.942" "1.042" "956.6" "971.0" "916.1" "935.4" "959.4" "947.0" "952.1" "1001.3" "901.1" "996.6" "" "" "" "" "" "" "" "" "" "" "956.6" "821.4" "579.2" "682.0" "786.0" "735.5" "733.9" "861.0" "703.3" "896.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "66.427" "22" "10" "28" "10" "499" "56.8" "6.28" "91.66" "10" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "MAPK signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "5" "0" "1.001" "1.009" "0.965" "1.015" "1.009" "1.010" "1.000" "1.039" "1.073" "1196.2" "1198.0" "1207.4" "1154.5" "1214.4" "1206.9" "1208.4" "1195.8" "1242.4" "1283.2" "" "" "" "" "" "" "" "" "" "" "1196.2" "1013.5" "763.4" "841.8" "995.0" "937.2" "931.5" "1028.2" "969.8" "1153.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "66.393" "22" "14" "21" "7" "590" "62.3" "7.74" "66.69" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "" "Formation of the cornified envelope; Type I hemidesmosome assembly" "3" "3" "0.308" "0.198" "0.294" "0.217" "0.292" "0.256" "0.183" "0.679" "0.168" "2832.6" "872.2" "561.1" "834.2" "616.1" "828.0" "725.9" "518.0" "1922.4" "476.6" "" "" "" "" "" "" "" "" "" "" "2832.6" "737.9" "354.8" "608.2" "504.7" "643.0" "559.6" "445.4" "1500.6" "428.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "66.337" "21" "14" "31" "14" "708" "76.5" "5.07" "94.66" "14" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "2" "0" "1.058" "1.135" "1.035" "1.122" "1.098" "1.128" "0.966" "1.122" "1.089" "1261.8" "1335.6" "1432.0" "1306.4" "1415.8" "1385.9" "1423.7" "1219.4" "1415.5" "1373.6" "" "" "" "" "" "" "" "" "" "" "1261.8" "1129.9" "905.4" "952.6" "1160.0" "1076.3" "1097.5" "1048.4" "1104.9" "1234.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8085176480319598229" "False" "High" "IsMasterProtein" "Q08188" "Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4" "0.000" "False" "66.078" "17" "10" "19" "10" "693" "76.6" "5.86" "66.47" "10" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00868, Pf00927, Pf01841" "7053" "ENSG00000125780" "TGM3" "A8K5N6; B2RCR6; D3DVX1; O95933; Q08188; Q32ML9; Q32MM0" "" "" "0" "0" "0.915" "1.008" "0.989" "0.958" "1.027" "0.995" "0.939" "1.026" "0.946" "1042.7" "953.9" "1050.9" "1031.6" "999.0" "1070.6" "1037.8" "979.2" "1069.4" "985.9" "" "" "" "" "" "" "" "" "" "" "1042.7" "807.0" "664.5" "752.2" "818.5" "831.4" "800.0" "841.9" "834.8" "886.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "66.004" "35" "13" "26" "11" "440" "49.2" "6.21" "68.70" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "64" "0" "0.945" "0.882" "0.953" "0.986" "0.906" "0.976" "0.945" "0.921" "0.991" "1487.2" "1405.7" "1312.0" "1416.8" "1466.2" "1346.9" "1452.0" "1405.3" "1369.7" "1474.1" "" "" "" "" "" "" "" "" "" "" "1487.2" "1189.2" "829.6" "1033.0" "1201.3" "1046.0" "1119.3" "1208.3" "1069.1" "1325.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "65.974" "27" "11" "25" "11" "445" "52.2" "6.04" "74.76" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.992" "1.040" "0.994" "0.988" "1.041" "0.999" "1.020" "1.049" "1.044" "1538.6" "1525.8" "1599.6" "1528.9" "1519.5" "1602.4" "1536.9" "1569.3" "1614.7" "1606.7" "" "" "" "" "" "" "" "" "" "" "1538.6" "1290.9" "1011.4" "1114.8" "1244.9" "1244.4" "1184.7" "1349.3" "1260.4" "1444.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "65.972" "51" "12" "29" "12" "255" "27.8" "8.10" "88.69" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "" "Respiratory electron transport; Protein methylation" "2" "0" "1.057" "1.005" "1.023" "1.061" "0.995" "1.014" "1.016" "1.050" "1.029" "1172.6" "1239.9" "1178.9" "1199.4" "1243.6" "1166.6" "1188.6" "1191.1" "1231.0" "1207.0" "" "" "" "" "" "" "" "" "" "" "1172.6" "1049.0" "745.5" "874.5" "1018.9" "905.9" "916.2" "1024.1" "960.9" "1085.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "65.969" "20" "10" "30" "10" "520" "57.3" "5.41" "99.70" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "13" "0" "1.003" "1.025" "0.967" "1.024" "0.998" "0.947" "0.993" "1.012" "1.036" "1768.6" "1773.6" "1813.5" "1710.6" "1810.3" "1764.5" "1675.5" "1755.9" "1789.6" "1832.4" "" "" "" "" "" "" "" "" "" "" "1768.6" "1500.5" "1146.7" "1247.3" "1483.2" "1370.3" "1291.6" "1509.7" "1396.9" "1647.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "65.968" "18" "13" "29" "13" "739" "83.1" "7.03" "87.77" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "HDAC6 interactions in the central nervous system" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.012" "0.996" "1.022" "0.970" "0.959" "0.972" "0.974" "0.938" "1.009" "1644.3" "1663.6" "1638.3" "1681.0" "1595.7" "1577.1" "1598.8" "1601.4" "1542.7" "1659.1" "" "" "" "" "" "" "" "" "" "" "1644.3" "1407.5" "1035.9" "1225.7" "1307.3" "1224.8" "1232.4" "1376.9" "1204.2" "1491.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "65.885" "16" "12" "19" "12" "923" "104.1" "5.57" "61.75" "12" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "1.029" "0.989" "1.067" "0.989" "0.899" "1.063" "1.055" "0.987" "0.978" "475.9" "489.8" "470.6" "507.6" "470.6" "427.7" "505.7" "502.0" "469.6" "465.7" "" "" "" "" "" "" "" "" "" "" "475.9" "414.4" "297.5" "370.1" "385.6" "332.1" "389.8" "431.7" "366.5" "418.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "65.866" "22" "7" "23" "7" "466" "52.1" "5.52" "91.58" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "3" "0" "1.080" "1.220" "1.057" "1.094" "1.253" "1.072" "1.006" "1.291" "1.158" "1081.1" "1167.3" "1319.4" "1142.2" "1183.1" "1354.9" "1159.3" "1087.3" "1396.2" "1251.6" "" "" "" "" "" "" "" "" "" "" "1081.1" "987.6" "834.2" "832.8" "969.4" "1052.2" "893.6" "934.8" "1089.8" "1125.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "65.779" "19" "17" "23" "17" "928" "106.1" "7.94" "76.04" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "51" "0" "0.921" "0.747" "1.017" "1.002" "0.745" "1.000" "0.961" "0.692" "0.886" "940.2" "866.1" "702.1" "955.7" "941.9" "700.2" "939.7" "903.6" "650.4" "832.8" "" "" "" "" "" "" "" "" "" "" "940.2" "732.7" "443.9" "696.9" "771.7" "543.8" "724.4" "776.9" "507.7" "748.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "65.687" "8" "17" "18" "17" "2813" "307.4" "5.24" "56.59" "17" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "8" "0" "1.017" "0.852" "1.083" "1.107" "0.933" "1.083" "1.056" "0.845" "0.962" "877.5" "892.9" "747.4" "950.8" "971.2" "818.4" "950.2" "926.7" "741.9" "844.0" "" "" "" "" "" "" "" "" "" "" "877.5" "755.4" "472.6" "693.2" "795.7" "635.5" "732.5" "796.7" "579.1" "758.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "65.512" "24" "13" "23" "13" "644" "74.4" "5.53" "78.55" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.036" "0.924" "1.001" "0.980" "0.851" "0.936" "0.980" "0.963" "1.031" "1063.9" "1102.0" "982.6" "1065.0" "1042.3" "904.9" "996.1" "1042.6" "1024.8" "1096.3" "" "" "" "" "" "" "" "" "" "" "1063.9" "932.3" "621.3" "776.6" "853.9" "702.7" "767.9" "896.4" "799.9" "985.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "65.462" "16" "15" "20" "12" "1094" "121.2" "6.04" "62.62" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "2" "3" "1.010" "0.956" "0.988" "1.027" "0.956" "1.013" "1.042" "0.969" "0.964" "917.5" "926.5" "876.8" "906.2" "942.6" "877.1" "929.8" "955.9" "888.8" "884.7" "" "" "" "" "" "" "" "" "" "" "917.5" "783.8" "554.4" "660.8" "772.3" "681.1" "716.7" "821.9" "693.7" "795.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "65.454" "12" "11" "18" "11" "1015" "114.3" "5.59" "56.10" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "" "Condensation of Prometaphase Chromosomes" "1" "0" "0.987" "0.681" "0.938" "0.942" "0.676" "1.002" "0.973" "0.733" "0.852" "828.5" "817.5" "564.0" "777.3" "780.2" "560.1" "830.5" "806.0" "606.9" "706.2" "" "" "" "" "" "" "" "" "" "" "828.5" "691.7" "356.6" "566.7" "639.2" "435.0" "640.2" "693.0" "473.7" "634.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "65.439" "29" "14" "21" "14" "514" "58.7" "6.43" "68.15" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "VEGFA-VEGFR2 signaling" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "3" "0" "1.113" "1.051" "1.070" "1.042" "1.098" "0.998" "1.013" "1.101" "1.092" "965.8" "1074.9" "1014.6" "1033.2" "1006.8" "1060.6" "964.3" "978.1" "1063.2" "1054.8" "" "" "" "" "" "" "" "" "" "" "965.8" "909.4" "641.6" "753.4" "824.9" "823.6" "743.3" "840.9" "829.9" "948.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "65.404" "26" "13" "17" "13" "659" "72.2" "7.64" "57.37" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.040" "0.973" "1.054" "1.068" "0.984" "1.008" "1.004" "1.013" "1.038" "614.1" "638.8" "597.4" "647.3" "655.8" "604.2" "619.1" "616.8" "622.2" "637.2" "" "" "" "" "" "" "" "" "" "" "614.1" "540.4" "377.8" "471.9" "537.3" "469.2" "477.2" "530.3" "485.7" "572.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "65.357" "35" "6" "89" "6" "231" "24.4" "7.18" "282.40" "6" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "0" "1.122" "1.210" "1.450" "1.053" "1.706" "1.175" "1.021" "1.297" "0.942" "3779.2" "4241.7" "4573.2" "5479.4" "3980.3" "6447.8" "4439.7" "3859.9" "4901.9" "3560.4" "" "" "" "" "" "" "" "" "" "" "3779.2" "3588.6" "2891.6" "3995.3" "3261.1" "5007.2" "3422.3" "3318.8" "3826.2" "3201.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "65.322" "18" "15" "21" "14" "972" "109.4" "5.00" "73.14" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "0.952" "0.898" "0.955" "0.923" "0.938" "0.989" "1.019" "0.921" "0.990" "667.4" "635.3" "599.1" "637.6" "616.1" "625.7" "659.9" "680.3" "614.4" "660.4" "" "" "" "" "" "" "" "" "" "" "667.4" "537.5" "378.8" "464.9" "504.8" "485.9" "508.7" "584.9" "479.5" "593.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3676506683142235675" "False" "High" "IsMasterProtein" "Q9NZN3" "EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2" "0.000" "False" "65.257" "18" "10" "30" "5" "535" "60.8" "6.57" "94.44" "10" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30845" "ENSG00000013016" "EHD3" "B4DFR5; D6W574; hsa:30845; Q8N514; Q9NZB3; Q9NZN3" "Ciliary landscape" "Factors involved in megakaryocyte development and platelet production" "2" "4" "1.018" "0.986" "1.057" "1.063" "0.987" "1.025" "1.051" "0.971" "0.989" "948.3" "965.5" "935.0" "1002.5" "1007.9" "935.6" "971.9" "996.3" "920.7" "938.0" "" "" "" "" "" "" "" "" "" "" "948.3" "816.8" "591.2" "731.0" "825.8" "726.6" "749.2" "856.6" "718.6" "843.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "65.202" "32" "11" "20" "6" "434" "49.7" "6.67" "66.57" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "2q37 copy number variation syndrome" "" "1" "6" "1.015" "1.045" "1.091" "1.067" "1.063" "1.024" "1.044" "1.069" "1.079" "1029.4" "1044.7" "1075.9" "1123.2" "1098.8" "1094.2" "1053.7" "1074.9" "1100.9" "1110.8" "" "" "" "" "" "" "" "" "" "" "1029.4" "883.8" "680.3" "819.0" "900.2" "849.7" "812.2" "924.2" "859.4" "998.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "65.185" "19" "10" "21" "10" "677" "73.3" "4.84" "74.70" "10" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "0.980" "0.750" "1.096" "1.040" "0.763" "1.013" "1.051" "0.791" "0.922" "1026.1" "1005.3" "769.4" "1124.4" "1067.4" "783.1" "1039.0" "1078.3" "812.0" "946.4" "" "" "" "" "" "" "" "" "" "" "1026.1" "850.5" "486.5" "819.8" "874.6" "608.1" "800.9" "927.2" "633.8" "850.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "65.154" "21" "12" "18" "11" "586" "66.4" "5.16" "64.92" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "RHOD GTPase cycle; RHOF GTPase cycle; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Meiotic synapsis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "14" "0" "0.923" "2.811" "1.030" "1.009" "2.905" "1.065" "0.959" "2.779" "1.434" "467.5" "431.4" "1314.1" "481.5" "471.8" "1357.8" "497.9" "448.1" "1299.0" "670.3" "" "" "" "" "" "" "" "" "" "" "467.5" "365.0" "830.9" "351.1" "386.6" "1054.5" "383.8" "385.3" "1013.9" "602.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "65.130" "7" "18" "20" "18" "2620" "294.2" "6.14" "65.80" "18" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "" "Ub-specific processing proteases" "1" "0" "1.039" "0.953" "1.019" "0.961" "0.924" "1.006" "0.997" "0.991" "1.015" "1162.4" "1207.4" "1107.6" "1184.0" "1117.2" "1074.4" "1169.4" "1158.5" "1152.5" "1180.2" "" "" "" "" "" "" "" "" "" "" "1162.4" "1021.5" "700.3" "863.3" "915.4" "834.4" "901.4" "996.1" "899.6" "1061.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "64.960" "10" "12" "18" "12" "1475" "153.8" "8.73" "61.78" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "TGF-beta signaling pathway" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "0.961" "0.883" "1.044" "1.016" "0.917" "1.107" "1.044" "0.900" "0.973" "539.4" "518.5" "476.5" "562.9" "547.8" "494.7" "597.2" "563.1" "485.5" "524.9" "" "" "" "" "" "" "" "" "" "" "539.4" "438.7" "301.3" "410.5" "448.9" "384.2" "460.3" "484.2" "378.9" "471.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "64.951" "7" "18" "23" "18" "2863" "318.9" "5.60" "67.34" "18" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "1.081" "0.974" "1.069" "1.031" "0.979" "1.086" "1.114" "0.968" "1.029" "1202.3" "1299.6" "1171.1" "1285.5" "1239.4" "1176.6" "1305.8" "1339.0" "1164.4" "1236.6" "" "" "" "" "" "" "" "" "" "" "1202.3" "1099.5" "740.5" "937.3" "1015.5" "913.7" "1006.6" "1151.3" "908.9" "1111.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.000" "False" "64.897" "17" "12" "26" "12" "770" "88.0" "6.30" "84.20" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "Signaling by ALK fusions and activated point mutants; Senescence-Associated Secretory Phenotype (SASP); Downstream signal transduction; Transcriptional regulation of granulopoiesis; PKR-mediated signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "119" "0" "0.963" "0.804" "1.006" "0.974" "0.804" "1.009" "1.005" "0.808" "0.930" "1441.4" "1387.4" "1159.4" "1449.7" "1404.5" "1158.6" "1453.7" "1448.4" "1165.1" "1339.9" "" "" "" "" "" "" "" "" "" "" "1441.4" "1173.8" "733.1" "1057.0" "1150.7" "899.8" "1120.5" "1245.3" "909.4" "1204.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "64.769" "36" "9" "26" "9" "254" "29.5" "5.95" "86.15" "9" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Proteasome degradation" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling" "60" "0" "0.984" "0.963" "0.979" "1.026" "0.965" "1.016" "1.012" "0.930" "0.987" "1299.5" "1278.9" "1250.8" "1272.3" "1332.7" "1253.9" "1320.7" "1315.6" "1208.7" "1282.3" "" "" "" "" "" "" "" "" "" "" "1299.5" "1082.0" "790.9" "927.7" "1091.9" "973.7" "1018.0" "1131.2" "943.5" "1152.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "64.728" "17" "12" "18" "8" "833" "95.3" "4.94" "60.93" "12" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "16p11.2 proximal deletion syndrome" "" "1" "3" "1.051" "0.899" "0.992" "1.003" "1.031" "0.949" "0.993" "0.908" "0.997" "501.8" "527.1" "451.1" "497.6" "503.5" "517.4" "476.2" "498.3" "455.7" "500.5" "" "" "" "" "" "" "" "" "" "" "501.8" "446.0" "285.2" "362.8" "412.6" "401.8" "367.1" "428.5" "355.7" "450.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "64.632" "22" "13" "20" "13" "637" "72.6" "6.29" "64.37" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "5" "0" "0.953" "0.983" "0.934" "0.929" "0.960" "0.919" "1.005" "0.952" "0.961" "1006.3" "958.6" "989.0" "940.2" "934.7" "966.2" "925.1" "1011.5" "958.2" "966.8" "" "" "" "" "" "" "" "" "" "" "1006.3" "811.0" "625.4" "685.5" "765.8" "750.4" "713.1" "869.7" "748.0" "869.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "64.558" "18" "13" "26" "13" "708" "80.5" "5.90" "69.97" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "HDR through MMEJ (alt-NHEJ); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "31" "0" "0.992" "0.910" "1.022" "1.026" "0.909" "0.989" "0.979" "0.885" "0.932" "871.9" "864.5" "793.0" "890.6" "894.3" "792.7" "861.9" "853.2" "771.4" "812.6" "" "" "" "" "" "" "" "" "" "" "871.9" "731.4" "501.4" "649.4" "732.7" "615.6" "664.4" "733.6" "602.1" "730.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "64.302" "23" "8" "22" "6" "415" "45.6" "5.58" "68.69" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.013" "0.853" "0.974" "1.003" "0.898" "1.038" "1.024" "0.844" "0.955" "991.1" "1003.7" "845.4" "965.7" "993.7" "890.3" "1028.7" "1015.0" "836.3" "946.9" "" "" "" "" "" "" "" "" "" "" "991.1" "849.2" "534.5" "704.1" "814.2" "691.4" "793.0" "872.7" "652.8" "851.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "64.016" "23" "12" "17" "12" "621" "68.8" "6.07" "60.86" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "1.103" "0.973" "1.092" "1.130" "0.965" "1.072" "1.141" "0.908" "1.065" "572.0" "631.0" "556.5" "624.7" "646.5" "551.9" "612.9" "652.7" "519.4" "609.0" "" "" "" "" "" "" "" "" "" "" "572.0" "533.8" "351.9" "455.5" "529.7" "428.6" "472.5" "561.2" "405.4" "547.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "63.892" "4" "19" "21" "19" "4678" "513.3" "7.02" "62.28" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "3q29 copy number variation syndrome" "" "1" "0" "1.092" "0.893" "1.037" "1.108" "0.918" "1.079" "1.088" "0.859" "1.042" "765.8" "836.2" "684.0" "793.8" "848.2" "702.8" "826.2" "833.2" "658.0" "797.7" "" "" "" "" "" "" "" "" "" "" "765.8" "707.4" "432.5" "578.8" "694.9" "545.8" "636.9" "716.4" "513.6" "717.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "63.862" "22" "16" "22" "16" "714" "81.8" "5.67" "71.54" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "7" "0" "0.992" "1.037" "0.980" "0.984" "1.047" "1.007" "1.041" "0.996" "1.014" "1066.1" "1057.4" "1105.1" "1044.2" "1048.7" "1115.7" "1073.4" "1110.2" "1062.1" "1080.8" "" "" "" "" "" "" "" "" "" "" "1066.1" "894.6" "698.7" "761.4" "859.2" "866.4" "827.4" "954.5" "829.1" "971.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "63.679" "36" "13" "23" "13" "366" "39.6" "6.92" "73.40" "13" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "5" "0" "0.982" "0.954" "0.848" "0.831" "0.825" "0.756" "0.829" "0.888" "0.901" "1274.5" "1250.9" "1215.9" "1080.6" "1059.7" "1051.1" "964.0" "1056.4" "1132.2" "1148.8" "" "" "" "" "" "" "" "" "" "" "1274.5" "1058.3" "768.8" "787.9" "868.2" "816.3" "743.1" "908.3" "883.8" "1032.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "63.661" "12" "14" "18" "14" "1192" "132.5" "6.19" "65.16" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.029" "0.902" "1.135" "1.044" "0.989" "1.051" "0.992" "0.981" "1.054" "1079.0" "1110.1" "973.8" "1225.0" "1127.0" "1066.7" "1134.4" "1070.3" "1058.7" "1137.0" "" "" "" "" "" "" "" "" "" "" "1079.0" "939.2" "615.7" "893.2" "923.3" "828.4" "874.4" "920.2" "826.4" "1022.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "63.637" "22" "11" "22" "6" "577" "60.9" "6.83" "69.56" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; tRNA processing in the nucleus; Processing of Intronless Pre-mRNAs" "6" "4" "0.975" "0.977" "0.992" "0.970" "1.063" "1.063" "0.933" "1.049" "0.998" "1353.6" "1319.3" "1322.1" "1342.8" "1313.2" "1438.3" "1438.7" "1263.5" "1420.1" "1351.5" "" "" "" "" "" "" "" "" "" "" "1353.6" "1116.2" "836.0" "979.1" "1075.9" "1116.9" "1109.0" "1086.3" "1108.5" "1215.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "63.390" "45" "9" "51" "6" "199" "22.1" "8.13" "156.66" "9" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "9" "3" "1.007" "1.051" "0.938" "0.983" "1.010" "0.981" "1.023" "0.984" "1.057" "3309.9" "3333.4" "3479.3" "3105.2" "3253.0" "3344.5" "3247.5" "3387.6" "3256.1" "3497.8" "" "" "" "" "" "" "" "" "" "" "3309.9" "2820.2" "2200.0" "2264.1" "2665.2" "2597.3" "2503.3" "2912.6" "2541.6" "3144.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "63.370" "29" "9" "22" "9" "380" "39.8" "8.94" "68.22" "9" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Integrin-mediated cell adhesion; Focal adhesion" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "5" "0" "0.982" "1.047" "0.989" "0.980" "1.016" "1.041" "0.983" "0.981" "0.982" "769.0" "755.4" "805.2" "760.5" "753.4" "781.1" "800.4" "756.0" "754.7" "755.4" "" "" "" "" "" "" "" "" "" "" "769.0" "639.1" "509.1" "554.5" "617.2" "606.6" "617.0" "650.0" "589.1" "679.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "63.217" "11" "10" "18" "10" "962" "109.9" "5.39" "57.65" "10" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "" "tRNA processing in the nucleus" "1" "0" "1.034" "1.090" "1.086" "1.048" "1.052" "1.027" "1.019" "1.110" "1.127" "555.6" "574.2" "605.6" "603.4" "582.2" "584.3" "570.6" "566.3" "616.7" "625.9" "" "" "" "" "" "" "" "" "" "" "555.6" "485.8" "382.9" "440.0" "477.0" "453.8" "439.8" "486.9" "481.3" "562.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "63.135" "52" "9" "24" "9" "241" "26.9" "5.17" "101.15" "9" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.984" "1.040" "1.070" "0.977" "1.049" "1.000" "0.966" "1.044" "1.178" "944.3" "928.8" "982.2" "1010.3" "922.8" "990.8" "944.1" "912.4" "985.6" "1112.6" "" "" "" "" "" "" "" "" "" "" "944.3" "785.8" "621.0" "736.6" "756.0" "769.5" "727.8" "784.5" "769.4" "1000.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "63.090" "38" "9" "35" "9" "289" "32.2" "4.96" "117.00" "9" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "1.035" "0.990" "1.099" "1.076" "0.976" "1.052" "1.024" "0.973" "1.020" "2428.9" "2512.7" "2404.3" "2670.3" "2613.6" "2371.7" "2554.2" "2486.5" "2364.5" "2476.6" "" "" "" "" "" "" "" "" "" "" "2428.9" "2125.8" "1520.2" "1947.0" "2141.3" "1841.8" "1968.9" "2137.9" "1845.7" "2226.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "63.071" "16" "9" "26" "9" "669" "73.4" "7.77" "81.27" "9" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "8" "0" "1.035" "1.058" "1.015" "1.035" "1.075" "0.988" "1.021" "1.017" "1.013" "1120.7" "1159.8" "1185.3" "1137.7" "1159.9" "1204.9" "1107.0" "1143.7" "1139.8" "1135.0" "" "" "" "" "" "" "" "" "" "" "1120.7" "981.2" "749.5" "829.5" "950.3" "935.7" "853.3" "983.4" "889.7" "1020.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "62.990" "25" "12" "19" "10" "522" "58.7" "6.33" "68.04" "12" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "1" "1.014" "1.134" "0.998" "1.032" "1.076" "1.064" "1.041" "1.045" "1.106" "697.5" "707.2" "790.7" "696.1" "720.0" "750.2" "741.9" "726.4" "728.7" "771.4" "" "" "" "" "" "" "" "" "" "" "697.5" "598.3" "500.0" "507.6" "589.9" "582.6" "571.9" "624.6" "568.8" "693.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "62.881" "20" "14" "23" "14" "858" "95.7" "5.03" "75.94" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "IL-18 signaling pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "3" "0" "1.002" "0.879" "1.002" "0.982" "0.884" "0.991" "1.005" "0.836" "0.924" "1485.2" "1488.0" "1305.2" "1488.3" "1458.7" "1312.5" "1471.8" "1492.7" "1241.7" "1372.7" "" "" "" "" "" "" "" "" "" "" "1485.2" "1258.9" "825.3" "1085.2" "1195.1" "1019.3" "1134.5" "1283.4" "969.2" "1234.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "62.851" "38" "12" "19" "2" "364" "40.3" "7.08" "63.44" "12" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "" "Circadian Clock" "1" "7" "1.048" "0.814" "0.984" "1.048" "0.894" "0.995" "1.069" "0.861" "0.938" "1104.7" "1157.4" "899.3" "1086.9" "1157.6" "987.6" "1099.2" "1181.1" "950.9" "1036.4" "" "" "" "" "" "" "" "" "" "" "1104.7" "979.2" "568.6" "792.5" "948.4" "767.0" "847.3" "1015.5" "742.2" "931.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "62.809" "39" "11" "23" "11" "326" "37.8" "8.84" "73.48" "11" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "Pleural mesothelioma" "" "1" "0" "1.047" "0.747" "1.019" "1.035" "0.743" "1.008" "1.040" "0.735" "0.924" "999.0" "1045.5" "745.9" "1017.8" "1033.6" "742.3" "1007.3" "1038.5" "734.2" "923.1" "" "" "" "" "" "" "" "" "" "" "999.0" "884.5" "471.6" "742.2" "846.9" "576.5" "776.5" "892.9" "573.1" "829.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "62.672" "32" "13" "20" "12" "404" "46.8" "6.76" "70.90" "13" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "" "Golgi Associated Vesicle Biogenesis" "1" "2" "0.978" "1.001" "0.993" "0.953" "0.949" "0.997" "0.991" "0.923" "0.922" "1954.5" "1911.2" "1956.8" "1940.9" "1862.0" "1855.5" "1949.1" "1936.3" "1803.8" "1801.1" "" "" "" "" "" "" "" "" "" "" "1954.5" "1617.0" "1237.3" "1415.2" "1525.5" "1440.9" "1502.5" "1664.9" "1408.0" "1619.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "62.648" "20" "7" "22" "7" "429" "47.4" "5.60" "62.90" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; HATs acetylate histones; DNA Damage Recognition in GG-NER" "10" "0" "0.967" "0.908" "0.978" "0.991" "0.891" "1.023" "0.991" "0.913" "0.949" "1002.5" "969.2" "909.8" "980.5" "993.0" "893.3" "1025.6" "993.1" "915.0" "951.6" "" "" "" "" "" "" "" "" "" "" "1002.5" "820.0" "575.3" "714.9" "813.6" "693.7" "790.5" "853.9" "714.2" "855.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "62.643" "15" "15" "16" "15" "1050" "119.5" "5.27" "55.83" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "1.013" "0.747" "1.000" "1.003" "0.740" "0.969" "1.040" "0.731" "0.966" "674.1" "683.1" "503.4" "673.8" "676.1" "498.7" "653.4" "701.3" "492.5" "651.5" "" "" "" "" "" "" "" "" "" "" "674.1" "577.9" "318.3" "491.3" "553.9" "387.3" "503.7" "603.0" "384.4" "585.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "62.439" "21" "12" "20" "12" "558" "61.4" "7.80" "72.28" "12" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "9" "0" "1.021" "1.397" "0.958" "1.148" "1.386" "1.012" "1.065" "1.292" "1.186" "1694.5" "1729.6" "2367.7" "1624.0" "1944.9" "2348.7" "1714.8" "1805.2" "2189.9" "2010.4" "" "" "" "" "" "" "" "" "" "" "1694.5" "1463.3" "1497.1" "1184.1" "1593.5" "1824.0" "1321.8" "1552.1" "1709.3" "1807.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "62.204" "38" "13" "47" "13" "334" "36.4" "7.36" "131.73" "13" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "Gluconeogenesis" "10" "0" "1.019" "1.042" "0.955" "0.971" "0.988" "0.942" "0.980" "1.039" "0.991" "3054.3" "3113.6" "3184.0" "2916.5" "2964.7" "3017.5" "2878.1" "2993.0" "3173.6" "3025.6" "" "" "" "" "" "" "" "" "" "" "3054.3" "2634.1" "2013.3" "2126.6" "2429.0" "2343.4" "2218.5" "2573.4" "2477.2" "2720.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "62.196" "7" "13" "16" "13" "3256" "358.5" "9.45" "57.11" "13" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "Primary focal segmental glomerulosclerosis (FSGS)" "" "1" "0" "1.048" "2.059" "1.040" "1.119" "2.081" "1.153" "0.936" "2.106" "1.272" "534.6" "560.2" "1100.8" "555.9" "598.1" "1112.7" "616.7" "500.2" "1125.7" "680.1" "" "" "" "" "" "" "" "" "" "" "534.6" "474.0" "696.0" "405.3" "490.0" "864.1" "475.4" "430.1" "878.7" "611.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "62.138" "23" "13" "22" "13" "650" "72.5" "5.74" "68.72" "13" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "0.989" "1.023" "1.044" "1.005" "1.022" "1.002" "0.997" "1.002" "1.046" "1128.5" "1116.3" "1154.3" "1177.8" "1134.0" "1153.5" "1130.3" "1125.3" "1130.2" "1180.0" "" "" "" "" "" "" "" "" "" "" "1128.5" "944.4" "729.9" "858.8" "929.1" "895.8" "871.3" "967.6" "882.2" "1060.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "62.114" "13" "13" "16" "11" "1001" "113.6" "6.29" "55.37" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "1.059" "0.915" "1.040" "1.111" "0.930" "1.057" "1.084" "0.930" "1.009" "889.4" "942.2" "814.2" "925.2" "987.9" "827.0" "939.8" "963.7" "827.1" "897.8" "" "" "" "" "" "" "" "" "" "" "889.4" "797.1" "514.8" "674.6" "809.4" "642.3" "724.4" "828.6" "645.6" "807.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "62.050" "32" "7" "12" "7" "377" "40.7" "4.79" "46.92" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.055" "0.940" "1.089" "0.972" "0.960" "0.982" "1.025" "0.993" "1.026" "638.6" "673.9" "600.5" "695.5" "620.8" "613.1" "627.2" "654.8" "634.5" "655.4" "" "" "" "" "" "" "" "" "" "" "638.6" "570.1" "379.7" "507.1" "508.6" "476.1" "483.5" "563.0" "495.2" "589.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "61.997" "22" "11" "32" "11" "494" "56.0" "5.30" "107.45" "11" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "2" "0" "1.007" "1.011" "1.005" "0.973" "0.955" "0.977" "0.985" "0.980" "0.943" "1741.6" "1753.8" "1760.4" "1750.8" "1694.0" "1662.4" "1700.8" "1715.2" "1707.6" "1642.0" "" "" "" "" "" "" "" "" "" "" "1741.6" "1483.7" "1113.1" "1276.6" "1387.9" "1291.0" "1311.0" "1474.8" "1332.9" "1476.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "61.910" "41" "10" "23" "10" "263" "29.6" "10.15" "80.17" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.951" "1.056" "1.042" "0.999" "1.049" "1.018" "1.119" "1.098" "1.044" "1124.0" "1068.8" "1186.7" "1171.0" "1123.2" "1179.3" "1144.8" "1257.7" "1234.7" "1174.0" "" "" "" "" "" "" "" "" "" "" "1124.0" "904.2" "750.4" "853.8" "920.3" "915.8" "882.4" "1081.4" "963.7" "1055.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "61.869" "11" "13" "17" "13" "1220" "132.9" "6.89" "62.64" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "6" "0" "1.057" "1.010" "1.048" "1.026" "1.001" "1.115" "1.097" "0.998" "1.019" "1054.0" "1114.1" "1064.5" "1104.3" "1081.5" "1055.1" "1174.8" "1156.1" "1052.3" "1074.2" "" "" "" "" "" "" "" "" "" "" "1054.0" "942.6" "673.1" "805.2" "886.1" "819.4" "905.6" "994.0" "821.4" "965.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "61.718" "30" "12" "28" "12" "439" "49.2" "5.24" "84.92" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.078" "1.012" "1.058" "1.091" "1.022" "1.060" "1.102" "0.978" "1.019" "1032.2" "1113.0" "1044.1" "1092.3" "1126.2" "1054.9" "1094.1" "1137.1" "1009.9" "1051.7" "" "" "" "" "" "" "" "" "" "" "1032.2" "941.6" "660.2" "796.4" "922.7" "819.2" "843.4" "977.7" "788.3" "945.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "61.662" "39" "10" "24" "10" "249" "28.7" "6.02" "80.58" "10" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.913" "1.018" "0.955" "0.922" "1.008" "0.968" "0.937" "0.961" "0.972" "1252.4" "1143.1" "1275.2" "1196.1" "1154.2" "1262.9" "1211.7" "1173.6" "1203.0" "1217.2" "" "" "" "" "" "" "" "" "" "" "1252.4" "967.1" "806.3" "872.1" "945.7" "980.7" "934.1" "1009.0" "939.0" "1094.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "61.578" "13" "12" "15" "11" "981" "112.3" "5.22" "51.72" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "" "Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "1" "0.961" "0.952" "0.980" "0.950" "0.893" "0.954" "0.986" "0.962" "0.969" "728.0" "699.8" "692.9" "713.1" "691.6" "650.4" "694.6" "717.8" "700.3" "705.2" "" "" "" "" "" "" "" "" "" "" "728.0" "592.1" "438.1" "520.0" "566.7" "505.1" "535.5" "617.2" "546.7" "634.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "61.517" "28" "10" "27" "10" "361" "41.5" "6.60" "94.93" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "2q37 copy number variation syndrome" "Anchoring of the basal body to the plasma membrane" "2" "0" "1.023" "1.069" "1.078" "1.009" "1.138" "1.050" "0.983" "1.170" "1.121" "1132.7" "1159.1" "1210.6" "1221.6" "1142.4" "1288.6" "1188.8" "1113.2" "1324.8" "1269.3" "" "" "" "" "" "" "" "" "" "" "1132.7" "980.6" "765.4" "890.7" "936.0" "1000.7" "916.4" "957.2" "1034.1" "1141.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "61.281" "30" "10" "23" "10" "430" "48.2" "5.05" "77.49" "10" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "T-cell receptor signaling pathway" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "4" "0" "0.998" "0.974" "1.003" "1.070" "1.021" "1.039" "1.036" "0.974" "1.006" "950.2" "947.9" "925.1" "953.0" "1016.8" "970.3" "987.2" "984.1" "925.4" "956.0" "" "" "" "" "" "" "" "" "" "" "950.2" "801.9" "584.9" "694.9" "833.1" "753.5" "760.9" "846.2" "722.3" "859.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "61.182" "35" "15" "24" "7" "472" "51.5" "5.16" "64.54" "15" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Type I hemidesmosome assembly" "4" "3" "0.380" "0.236" "0.349" "0.282" "0.329" "0.398" "0.226" "0.576" "0.243" "1045.5" "397.4" "246.6" "365.3" "295.1" "343.6" "415.7" "235.9" "602.5" "254.2" "" "" "" "" "" "" "" "" "" "" "1045.5" "336.2" "155.9" "266.4" "241.7" "266.8" "320.5" "202.8" "470.3" "228.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "61.093" "11" "16" "19" "13" "1388" "160.8" "6.02" "54.84" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "27" "0" "1.018" "1.027" "1.086" "1.074" "1.051" "1.074" "1.101" "1.056" "1.028" "704.9" "717.6" "724.1" "765.3" "756.8" "740.8" "757.2" "776.1" "744.5" "724.6" "" "" "" "" "" "" "" "" "" "" "704.9" "607.1" "457.9" "558.0" "620.0" "575.3" "583.7" "667.3" "581.1" "651.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "61.014" "18" "10" "14" "10" "635" "72.0" "8.25" "53.45" "10" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Integrin signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "30" "0" "1.055" "0.930" "1.040" "0.994" "0.949" "1.001" "0.966" "0.860" "0.976" "477.8" "504.0" "444.2" "497.1" "474.8" "453.2" "478.2" "461.6" "411.0" "466.5" "" "" "" "" "" "" "" "" "" "" "477.8" "426.4" "280.9" "362.5" "389.0" "352.0" "368.6" "396.9" "320.8" "419.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "60.987" "46" "12" "32" "12" "263" "29.5" "6.61" "92.45" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neddylation; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.011" "1.066" "1.024" "1.009" "1.093" "0.994" "0.990" "1.082" "0.997" "1144.8" "1157.1" "1220.6" "1172.4" "1155.5" "1251.7" "1138.0" "1133.8" "1238.2" "1141.5" "" "" "" "" "" "" "" "" "" "" "1144.8" "979.0" "771.8" "854.9" "946.7" "972.0" "877.2" "974.8" "966.5" "1026.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "60.966" "7" "12" "17" "12" "2090" "213.5" "7.47" "61.58" "12" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "TGF-beta signaling pathway" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; HuR (ELAVL1) binds and stabilizes mRNA" "30" "0" "0.988" "0.955" "1.017" "1.027" "0.960" "1.063" "1.011" "0.925" "0.954" "1143.5" "1129.5" "1092.2" "1162.7" "1174.3" "1097.9" "1216.1" "1156.5" "1057.8" "1091.3" "" "" "" "" "" "" "" "" "" "" "1143.5" "955.6" "690.6" "847.8" "962.1" "852.6" "937.4" "994.3" "825.7" "981.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "60.899" "16" "17" "17" "17" "1107" "123.6" "7.03" "55.13" "17" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "27" "0" "1.060" "0.853" "1.108" "1.061" "0.892" "1.068" "0.962" "0.924" "0.985" "796.1" "844.0" "679.3" "882.1" "844.5" "710.1" "850.3" "765.6" "735.2" "784.0" "" "" "" "" "" "" "" "" "" "" "796.1" "714.0" "429.5" "643.2" "691.9" "551.5" "655.5" "658.3" "573.9" "704.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "60.817" "29" "8" "20" "8" "352" "39.9" "6.54" "69.12" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "10" "0" "0.952" "1.093" "0.936" "0.976" "1.032" "0.961" "0.982" "0.979" "0.924" "1383.4" "1317.1" "1512.4" "1294.7" "1349.6" "1427.7" "1329.3" "1358.9" "1353.9" "1277.6" "" "" "" "" "" "" "" "" "" "" "1383.4" "1114.3" "956.3" "944.0" "1105.7" "1108.7" "1024.7" "1168.4" "1056.8" "1148.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "60.775" "31" "8" "25" "7" "375" "42.8" "4.69" "75.36" "8" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "0" "1.055" "1.105" "1.103" "1.060" "1.066" "1.042" "1.012" "1.094" "1.031" "1314.7" "1387.5" "1452.2" "1450.8" "1393.0" "1402.1" "1369.8" "1331.0" "1438.9" "1355.8" "" "" "" "" "" "" "" "" "" "" "1314.7" "1173.9" "918.2" "1057.9" "1141.3" "1088.9" "1055.9" "1144.4" "1123.2" "1218.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "60.768" "27" "6" "13" "6" "308" "33.4" "5.69" "53.83" "6" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "" "Cytosolic sulfonation of small molecules" "1" "0" "1.010" "0.975" "0.976" "0.943" "1.022" "0.909" "0.958" "1.001" "1.013" "338.5" "341.9" "330.2" "330.5" "319.3" "345.8" "307.6" "324.2" "339.0" "342.9" "" "" "" "" "" "" "" "" "" "" "338.5" "289.2" "208.8" "240.9" "261.6" "268.6" "237.1" "278.8" "264.6" "308.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "60.728" "12" "12" "17" "12" "1007" "113.5" "9.16" "60.65" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "1.001" "0.993" "1.051" "1.009" "1.060" "1.062" "1.045" "1.037" "0.997" "1035.0" "1036.4" "1028.0" "1088.2" "1044.3" "1097.6" "1099.3" "1081.1" "1073.3" "1031.9" "" "" "" "" "" "" "" "" "" "" "1035.0" "876.8" "650.0" "793.5" "855.6" "852.3" "847.4" "929.6" "837.8" "927.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.000" "False" "60.714" "18" "12" "15" "12" "709" "79.7" "6.34" "53.13" "12" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "1.046" "0.802" "1.049" "1.046" "0.832" "1.042" "1.074" "0.836" "0.958" "919.3" "961.5" "737.2" "964.3" "961.2" "765.2" "958.2" "986.9" "768.5" "881.1" "" "" "" "" "" "" "" "" "" "" "919.3" "813.5" "466.2" "703.1" "787.5" "594.2" "738.6" "848.5" "599.8" "792.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "60.575" "19" "11" "17" "11" "641" "70.0" "8.38" "56.42" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.992" "1.209" "0.984" "0.940" "1.223" "1.007" "0.994" "1.107" "1.005" "898.8" "891.9" "1086.6" "884.3" "845.2" "1099.1" "905.3" "893.4" "994.6" "903.1" "" "" "" "" "" "" "" "" "" "" "898.8" "754.5" "687.1" "644.8" "692.5" "853.6" "697.8" "768.1" "776.4" "811.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "60.560" "14" "9" "15" "9" "740" "81.5" "7.66" "54.91" "9" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "Nucleotide-binding oligomerization domain (NOD) pathway" "" "1" "0" "1.112" "0.900" "1.139" "1.009" "1.007" "1.160" "1.113" "0.958" "1.075" "394.6" "438.9" "355.1" "449.5" "398.3" "397.4" "457.8" "439.1" "378.0" "424.4" "" "" "" "" "" "" "" "" "" "" "394.6" "371.3" "224.5" "327.8" "326.3" "308.6" "352.9" "377.5" "295.1" "381.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120903851432865653" "False" "High" "IsMasterProtein" "P01889" "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" "0.000" "False" "60.555" "23" "7" "19" "3" "362" "40.4" "5.85" "71.41" "7" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3106" "ENSG00000234745" "HLA-B" "A0A2I6Q7B5; B0V0B8; G3GN01; hsa:3106; O02862; O02956; O02957; O02960; O19555; O19556; O19595; O19615; O19624; O19625; O19627; O19641; O19651; O19675; O19692; O19758; O19779; O19783; O46702; O62897; O62901; O62915; O62917; O62919; O77933; O77959; O78053; O78138; O78160; O78163; O78172; O78173; O78180; O78217; O95730; O98140; P01889; P01890; P03989; P10317; P10318; P10319; P10320; P18463; P18464; P18465; P19373; P30460; P30461; P30462; P30463; P30464; P30465; P30466; P30467; P30468; P30469; P30470; P30471; P30472; P30473; P30474; P30475; P30476; P30477; P30478; P30479; P30480; P30481; P30482; P30483; P30484; P30485; P30486; P30487; P30488; P30489; P30490; P30491; P30492; P30493; P30494; P30495; P30496; P30497; P30498; P30513; P30685; P79489; P79490; P79496; P79504; P79523; P79524; P79542; P79555; Q04826; Q08136; Q29633; Q29636; Q29638; Q29661; Q29665; Q29678; Q29679; Q29681; Q29693; Q29695; Q29697; Q29718; Q29742; Q29749; Q29762; Q29764; Q29829; Q29836; Q29842; Q29845; Q29846; Q29847; Q29848; Q29850; Q29851; Q29852; Q29854; Q29855; Q29857; Q29858; Q29861; Q29924; Q29925; Q29933; Q29935; Q29936; Q29940; Q29953; Q29961; Q29982; Q30173; Q30198; Q31603; Q31610; Q31612; Q31613; Q546L8; Q546M4; Q5JP37; Q5QT24; Q5RIP1; Q5SRJ2; Q5TK76; Q5TK77; Q860I4; Q861B5; Q8HWF0; Q8MGQ3; Q8MHN4; Q8SNC5; Q95343; Q95344; Q95365; Q95369; Q95392; Q95HA3; Q95HA8; Q95HM9; Q95IA6; Q95IB8; Q95IH5; Q95J00; Q96IT9; Q9BCM6; Q9BCM7; Q9BCM8; Q9BD06; Q9BD38; Q9BD43; Q9GIL3; Q9GIM3; Q9GIX1; Q9GIY5; Q9GIZ0; Q9GIZ9; Q9GJ00; Q9GJ17; Q9GJ20; Q9GJ23; Q9GJ31; Q9GJF0; Q9GJM7; Q9MX21; Q9MY37; Q9MY42; Q9MY43; Q9MY61; Q9MY75; Q9MY78; Q9MY79; Q9MY84; Q9MY92; Q9MY93; Q9MY94; Q9MYB8; Q9MYC3; Q9MYC7; Q9MYF4; Q9MYG1; Q9TP35; Q9TP36; Q9TP37; Q9TP95; Q9TPQ7; Q9TPQ9; Q9TPR2; Q9TPR4; Q9TPS6; Q9TPT2; Q9TPT4; Q9TPT6; Q9TPV2; Q9TQG1; Q9TQH3; Q9TQH6; Q9TQH7; Q9TQH8; Q9TQH9; Q9TQM2; Q9TQN4; Q9TQN6; Q9UQS8; Q9UQT0" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome; Type II interferon signaling" "DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "14" "4" "1.060" "1.046" "1.081" "1.134" "1.010" "1.217" "1.175" "1.009" "1.092" "752.6" "798.0" "786.9" "813.4" "853.5" "760.2" "916.2" "884.2" "759.4" "821.7" "" "" "" "" "" "" "" "" "" "" "752.6" "675.1" "497.6" "593.1" "699.3" "590.4" "706.3" "760.3" "592.7" "738.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "60.382" "21" "9" "19" "9" "546" "59.2" "4.36" "68.32" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "VEGFA-VEGFR2 signaling; mRNA processing" "" "2" "0" "1.004" "1.092" "1.053" "1.024" "1.021" "1.043" "1.012" "0.993" "1.049" "1039.2" "1042.9" "1134.4" "1094.8" "1064.4" "1060.9" "1083.6" "1051.3" "1031.4" "1090.4" "" "" "" "" "" "" "" "" "" "" "1039.2" "882.3" "717.3" "798.3" "872.1" "823.8" "835.3" "903.9" "805.1" "980.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "60.375" "48" "10" "27" "10" "197" "22.6" "7.11" "83.08" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.938" "1.015" "0.927" "0.968" "1.020" "1.018" "0.960" "1.013" "1.001" "1594.9" "1496.5" "1618.4" "1479.0" "1543.9" "1626.2" "1623.6" "1531.5" "1615.3" "1596.4" "" "" "" "" "" "" "" "" "" "" "1594.9" "1266.1" "1023.3" "1078.4" "1265.0" "1262.9" "1251.6" "1316.8" "1260.9" "1435.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "60.358" "20" "12" "23" "12" "640" "70.7" "7.62" "65.75" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "Gluconeogenesis" "7" "0" "1.056" "1.040" "1.041" "1.013" "1.021" "1.011" "1.062" "1.063" "1.029" "1022.0" "1079.3" "1062.9" "1064.2" "1035.7" "1043.2" "1033.4" "1085.6" "1086.8" "1051.5" "" "" "" "" "" "" "" "" "" "" "1022.0" "913.1" "672.0" "775.9" "848.5" "810.1" "796.6" "933.4" "848.3" "945.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "60.304" "24" "9" "25" "9" "378" "44.4" "5.25" "82.44" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "RHOBTB2 GTPase cycle; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "27" "0" "0.973" "1.040" "1.013" "1.028" "1.012" "1.026" "1.036" "0.989" "0.970" "1523.8" "1482.8" "1584.9" "1544.2" "1567.3" "1542.0" "1563.2" "1578.8" "1507.6" "1478.5" "" "" "" "" "" "" "" "" "" "" "1523.8" "1254.5" "1002.1" "1125.9" "1284.1" "1197.5" "1205.0" "1357.4" "1176.8" "1329.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "60.285" "31" "11" "23" "11" "406" "46.2" "5.83" "72.23" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle" "6" "0" "1.012" "1.105" "1.062" "1.011" "1.099" "1.016" "1.013" "1.039" "1.036" "963.9" "975.1" "1064.8" "1023.8" "974.4" "1059.2" "979.4" "976.0" "1001.9" "999.0" "" "" "" "" "" "" "" "" "" "" "963.9" "825.0" "673.3" "746.5" "798.3" "822.5" "755.0" "839.1" "782.0" "898.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "60.259" "22" "11" "16" "11" "563" "61.3" "7.68" "54.48" "11" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Branched-chain amino acid catabolism" "3" "0" "1.078" "1.099" "0.958" "1.010" "1.108" "0.979" "1.058" "1.139" "1.088" "682.4" "735.4" "749.9" "653.9" "689.2" "756.4" "668.4" "721.7" "777.4" "742.4" "" "" "" "" "" "" "" "" "" "" "682.4" "622.1" "474.2" "476.8" "564.7" "587.4" "515.2" "620.5" "606.8" "667.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "59.950" "45" "6" "20" "6" "187" "21.0" "7.53" "79.91" "6" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "9" "0" "0.949" "1.077" "0.955" "0.993" "1.078" "0.984" "0.951" "1.106" "1.084" "1750.9" "1660.9" "1884.8" "1672.8" "1738.1" "1886.7" "1723.0" "1664.5" "1936.9" "1898.5" "" "" "" "" "" "" "" "" "" "" "1750.9" "1405.2" "1191.8" "1219.7" "1424.0" "1465.2" "1328.2" "1431.2" "1511.8" "1706.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "59.937" "37" "9" "21" "9" "244" "27.3" "5.15" "71.41" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.023" "1.030" "0.997" "0.981" "1.070" "0.994" "0.997" "1.043" "1.047" "749.1" "766.2" "771.4" "746.9" "735.2" "801.4" "744.6" "747.2" "781.5" "784.4" "" "" "" "" "" "" "" "" "" "" "749.1" "648.2" "487.8" "544.6" "602.4" "622.4" "574.0" "642.5" "610.0" "705.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6544422487784178027" "False" "High" "IsMasterProtein" "Q8IVW6" "AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2" "0.000" "False" "59.846" "27" "12" "16" "12" "561" "60.6" "7.52" "54.49" "12" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01388" "10620" "ENSG00000179361" "ARID3B" "hsa:10620; O95443; Q59HC9; Q6P9C9; Q8IVW6" "" "" "0" "0" "0.976" "0.882" "1.042" "0.969" "0.885" "1.009" "1.055" "0.858" "0.919" "960.7" "937.7" "847.0" "1000.7" "931.2" "850.4" "969.8" "1013.9" "824.0" "882.6" "" "" "" "" "" "" "" "" "" "" "960.7" "793.3" "535.6" "729.6" "763.0" "660.4" "747.6" "871.8" "643.2" "793.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "59.819" "16" "13" "15" "13" "919" "101.7" "5.62" "51.02" "13" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "14" "0" "0.959" "0.807" "0.941" "0.981" "0.865" "0.929" "0.948" "0.877" "0.923" "880.0" "843.6" "710.2" "828.3" "863.4" "761.2" "817.4" "834.2" "772.1" "812.5" "" "" "" "" "" "" "" "" "" "" "880.0" "713.7" "449.0" "604.0" "707.4" "591.1" "630.1" "717.2" "602.7" "730.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "59.814" "17" "12" "21" "12" "776" "89.6" "8.00" "68.96" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "Iron uptake and transport; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "41" "0" "1.001" "1.067" "0.993" "1.004" "1.096" "0.956" "0.996" "1.014" "1.030" "1500.2" "1501.3" "1601.2" "1490.1" "1505.7" "1644.5" "1434.3" "1494.8" "1521.3" "1544.9" "" "" "" "" "" "" "" "" "" "" "1500.2" "1270.2" "1012.4" "1086.5" "1233.6" "1277.1" "1105.6" "1285.2" "1187.5" "1389.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "59.813" "24" "13" "18" "10" "622" "68.9" "7.15" "60.40" "13" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "6" "0" "0.995" "1.012" "1.042" "1.071" "1.108" "1.053" "1.032" "0.958" "1.008" "757.3" "753.8" "766.2" "789.3" "811.0" "839.0" "797.4" "781.7" "725.3" "763.6" "" "" "" "" "" "" "" "" "" "" "757.3" "637.8" "484.5" "575.5" "664.4" "651.5" "614.7" "672.1" "566.1" "686.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "59.737" "12" "10" "12" "10" "985" "107.3" "6.27" "49.01" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "1.067" "0.865" "1.053" "1.081" "0.965" "1.064" "1.053" "0.881" "1.034" "747.3" "797.7" "646.5" "786.6" "807.9" "720.9" "795.0" "786.8" "658.6" "772.7" "" "" "" "" "" "" "" "" "" "" "747.3" "674.9" "408.8" "573.6" "661.9" "559.8" "612.8" "676.5" "514.0" "694.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "59.644" "40" "11" "18" "11" "334" "37.5" "7.36" "58.83" "11" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "Ub-specific processing proteases; Methylation" "8" "0" "0.994" "0.952" "0.938" "0.900" "0.941" "0.920" "0.999" "0.955" "0.960" "827.9" "822.9" "788.0" "776.6" "745.1" "778.8" "762.0" "827.1" "790.8" "794.6" "" "" "" "" "" "" "" "" "" "" "827.9" "696.2" "498.3" "566.3" "610.5" "604.8" "587.3" "711.2" "617.2" "714.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "59.574" "11" "10" "30" "10" "881" "95.4" "7.62" "102.17" "10" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "6" "0" "1.037" "0.963" "1.005" "0.981" "0.912" "0.978" "0.994" "0.945" "0.928" "2398.8" "2487.2" "2309.3" "2409.9" "2352.3" "2187.9" "2347.1" "2384.5" "2267.1" "2225.8" "" "" "" "" "" "" "" "" "" "" "2398.8" "2104.2" "1460.2" "1757.2" "1927.2" "1699.1" "1809.2" "2050.2" "1769.6" "2001.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "59.551" "21" "16" "21" "16" "724" "84.0" "5.83" "62.19" "16" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "2" "0" "1.004" "0.728" "1.055" "1.042" "0.778" "1.091" "1.052" "0.741" "0.913" "1349.3" "1355.0" "982.7" "1423.1" "1406.0" "1049.1" "1471.7" "1419.8" "999.6" "1232.1" "" "" "" "" "" "" "" "" "" "" "1349.3" "1146.4" "621.4" "1037.7" "1151.9" "814.7" "1134.4" "1220.7" "780.3" "1107.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "59.351" "15" "13" "15" "13" "845" "98.3" "6.62" "51.33" "13" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "38" "0" "1.046" "0.770" "1.009" "0.990" "0.740" "0.955" "1.037" "0.774" "0.977" "1132.2" "1184.6" "871.9" "1142.4" "1120.9" "838.3" "1081.6" "1174.4" "876.9" "1106.1" "" "" "" "" "" "" "" "" "" "" "1132.2" "1002.2" "551.3" "833.0" "918.4" "651.0" "833.8" "1009.7" "684.4" "994.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "59.284" "23" "6" "18" "6" "359" "39.2" "6.65" "58.65" "6" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "8" "0" "1.040" "1.022" "1.015" "1.109" "1.064" "0.997" "1.087" "1.034" "1.122" "583.6" "606.8" "596.2" "592.1" "647.3" "620.9" "581.7" "634.5" "603.3" "654.6" "" "" "" "" "" "" "" "" "" "" "583.6" "513.4" "377.0" "431.7" "530.4" "482.2" "448.4" "545.5" "470.9" "588.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "59.253" "10" "13" "13" "13" "1498" "167.3" "5.44" "48.50" "13" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "" "RND2 GTPase cycle" "1" "0" "1.023" "0.972" "1.136" "1.048" "1.036" "1.187" "1.051" "1.020" "1.137" "469.6" "480.5" "456.3" "533.3" "492.0" "486.7" "557.3" "493.7" "479.2" "533.9" "" "" "" "" "" "" "" "" "" "" "469.6" "406.5" "288.5" "388.9" "403.1" "377.9" "429.6" "424.4" "374.0" "480.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "59.245" "46" "7" "56" "6" "166" "18.5" "8.09" "201.54" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "15" "1" "0.920" "1.095" "0.904" "0.927" "1.060" "0.895" "0.972" "1.081" "1.060" "3952.5" "3636.7" "4327.1" "3572.6" "3665.8" "4191.2" "3537.9" "3841.0" "4273.1" "4191.2" "" "" "" "" "" "" "" "" "" "" "3952.5" "3076.7" "2736.0" "2604.9" "3003.4" "3254.8" "2727.1" "3302.5" "3335.4" "3768.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "59.230" "16" "13" "15" "13" "904" "98.6" "8.40" "47.68" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "1.025" "0.920" "1.065" "1.064" "1.084" "1.050" "1.058" "1.041" "1.011" "633.3" "649.2" "582.6" "674.7" "673.8" "686.8" "665.1" "669.8" "659.4" "640.3" "" "" "" "" "" "" "" "" "" "" "633.3" "549.2" "368.4" "491.9" "552.1" "533.4" "512.7" "575.9" "514.7" "575.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "59.209" "19" "12" "16" "12" "704" "77.7" "7.08" "60.80" "12" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "0.832" "0.900" "0.824" "0.787" "1.087" "0.787" "0.771" "1.141" "0.890" "977.3" "813.4" "879.1" "805.4" "768.7" "1062.4" "768.6" "753.1" "1115.2" "869.9" "" "" "" "" "" "" "" "" "" "" "977.3" "688.2" "555.9" "587.2" "629.8" "825.0" "592.5" "647.5" "870.5" "782.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "59.191" "11" "11" "19" "11" "1046" "116.9" "6.70" "62.35" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "8" "0" "1.021" "0.853" "1.072" "1.083" "1.012" "1.033" "1.033" "0.941" "0.995" "557.5" "569.2" "475.6" "597.6" "603.5" "564.0" "575.7" "575.9" "524.4" "554.5" "" "" "" "" "" "" "" "" "" "" "557.5" "481.6" "300.7" "435.8" "494.5" "438.0" "443.7" "495.2" "409.3" "498.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "59.188" "16" "12" "15" "12" "902" "101.4" "8.40" "55.90" "12" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.977" "0.892" "0.990" "1.021" "0.909" "0.978" "1.052" "0.860" "0.971" "734.6" "717.5" "655.0" "726.9" "749.9" "668.1" "718.7" "773.2" "631.9" "713.2" "" "" "" "" "" "" "" "" "" "" "734.6" "607.0" "414.1" "530.0" "614.4" "518.8" "554.0" "664.8" "493.2" "641.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "59.140" "22" "9" "27" "8" "437" "50.6" "8.63" "80.15" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "" "MAPK6/MAPK4 signaling" "1" "0" "1.031" "1.053" "1.030" "1.020" "1.086" "1.008" "1.005" "1.089" "1.005" "1479.2" "1525.0" "1557.9" "1523.7" "1508.6" "1606.2" "1491.4" "1487.3" "1611.1" "1486.1" "" "" "" "" "" "" "" "" "" "" "1479.2" "1290.2" "985.1" "1111.0" "1236.0" "1247.3" "1149.6" "1278.8" "1257.6" "1336.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6096160842803463632" "False" "High" "IsMasterProtein" "Q9NQX3" "Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1" "0.000" "False" "59.077" "18" "12" "17" "12" "736" "79.7" "5.43" "62.19" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00994, Pf03453, Pf03454" "10243" "ENSG00000171723" "GPHN" "hsa:10243; Q96KU4; Q9H4E9; Q9NQX3; Q9P2G2" "Splicing factor NOVA regulated synaptic proteins; GABA receptor signaling; Fragile X syndrome; Metabolic Epileptic Disorders; Cell lineage map for neuronal differentiation" "Molybdenum cofactor biosynthesis" "6" "0" "0.974" "0.988" "1.006" "0.995" "0.980" "1.018" "1.017" "0.938" "0.980" "865.4" "843.3" "855.0" "870.9" "861.3" "848.4" "880.8" "880.2" "812.0" "847.7" "" "" "" "" "" "" "" "" "" "" "865.4" "713.4" "540.6" "635.0" "705.6" "658.8" "678.9" "756.8" "633.8" "762.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "58.958" "19" "8" "19" "8" "548" "63.9" "6.05" "70.12" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "0.985" "1.084" "0.964" "0.997" "1.070" "0.964" "1.008" "1.024" "1.025" "1051.2" "1034.9" "1139.2" "1013.4" "1047.9" "1125.1" "1013.4" "1059.7" "1076.0" "1077.3" "" "" "" "" "" "" "" "" "" "" "1051.2" "875.6" "720.3" "738.9" "858.5" "873.7" "781.2" "911.1" "839.9" "968.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "58.906" "25" "12" "26" "12" "478" "53.9" "6.58" "88.65" "12" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "0" "0.955" "0.862" "0.994" "0.978" "0.837" "0.937" "0.984" "0.833" "0.965" "1442.4" "1377.0" "1243.4" "1434.1" "1410.5" "1207.2" "1351.3" "1419.5" "1201.8" "1392.6" "" "" "" "" "" "" "" "" "" "" "1442.4" "1165.0" "786.2" "1045.7" "1155.6" "937.5" "1041.7" "1220.5" "938.1" "1252.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "58.882" "25" "11" "25" "11" "511" "56.5" "5.81" "67.28" "11" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "1.078" "1.159" "1.042" "1.116" "1.096" "1.035" "1.054" "1.043" "0.989" "1004.8" "1083.3" "1164.6" "1046.7" "1121.6" "1101.0" "1039.7" "1059.3" "1048.5" "994.2" "" "" "" "" "" "" "" "" "" "" "1004.8" "916.5" "736.4" "763.2" "919.0" "855.0" "801.5" "910.8" "818.4" "893.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "58.655" "10" "10" "14" "10" "1303" "140.2" "6.27" "51.18" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "0.927" "1.172" "1.012" "1.031" "1.232" "1.045" "1.001" "1.119" "1.050" "933.4" "865.0" "1094.0" "944.3" "962.2" "1149.6" "975.9" "934.5" "1044.1" "979.9" "" "" "" "" "" "" "" "" "" "" "933.4" "731.8" "691.7" "688.5" "788.3" "892.8" "752.2" "803.5" "815.0" "881.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "58.500" "32" "13" "19" "13" "457" "51.2" "5.90" "70.69" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "7" "0" "0.978" "0.875" "0.966" "0.922" "0.818" "0.910" "0.930" "0.846" "0.931" "1593.0" "1558.2" "1393.8" "1538.5" "1469.4" "1302.9" "1450.3" "1482.1" "1347.9" "1482.7" "" "" "" "" "" "" "" "" "" "" "1593.0" "1318.2" "881.3" "1121.8" "1203.9" "1011.8" "1117.9" "1274.3" "1052.1" "1333.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "58.376" "19" "8" "38" "8" "419" "48.2" "6.15" "123.11" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "9" "0" "0.968" "1.112" "1.053" "0.997" "1.064" "0.996" "1.049" "1.070" "1.078" "3733.6" "3612.7" "4150.8" "3931.1" "3722.7" "3973.1" "3720.3" "3917.3" "3993.5" "4026.6" "" "" "" "" "" "" "" "" "" "" "3733.6" "3056.4" "2624.6" "2866.4" "3050.0" "3085.4" "2867.7" "3368.1" "3117.1" "3620.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "58.116" "16" "8" "13" "8" "631" "71.6" "4.65" "50.43" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "13" "0" "0.964" "0.814" "0.960" "0.998" "0.862" "0.935" "0.952" "0.793" "0.888" "565.8" "545.4" "460.7" "543.0" "564.8" "487.7" "528.9" "538.7" "448.9" "502.4" "" "" "" "" "" "" "" "" "" "" "565.8" "461.5" "291.3" "395.9" "462.7" "378.8" "407.7" "463.2" "350.4" "451.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "58.047" "17" "14" "28" "14" "847" "94.6" "6.25" "83.17" "14" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.021" "1.552" "1.021" "1.118" "1.648" "1.136" "1.200" "1.481" "1.210" "931.8" "951.1" "1446.0" "951.1" "1042.0" "1535.2" "1058.5" "1118.0" "1379.6" "1127.8" "" "" "" "" "" "" "" "" "" "" "931.8" "804.6" "914.3" "693.5" "853.7" "1192.2" "816.0" "961.2" "1076.8" "1013.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "58.015" "27" "15" "20" "12" "573" "65.3" "6.20" "59.13" "15" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; RHO GTPases activate KTN1" "8" "1" "1.060" "0.917" "0.964" "0.999" "1.016" "1.061" "1.071" "0.976" "1.027" "713.8" "756.9" "654.7" "687.8" "713.2" "725.2" "757.7" "764.5" "696.7" "733.4" "" "" "" "" "" "" "" "" "" "" "713.8" "640.3" "414.0" "501.5" "584.3" "563.2" "584.0" "657.3" "543.8" "659.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "57.975" "46" "12" "28" "12" "264" "29.9" "9.73" "84.93" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.983" "1.054" "0.961" "0.981" "1.065" "1.043" "1.107" "1.122" "1.006" "1528.1" "1502.8" "1610.1" "1468.1" "1499.8" "1628.0" "1593.9" "1691.3" "1713.9" "1537.3" "" "" "" "" "" "" "" "" "" "" "1528.1" "1271.4" "1018.1" "1070.5" "1228.8" "1264.3" "1228.7" "1454.2" "1337.8" "1382.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "57.960" "16" "10" "22" "10" "701" "75.7" "6.77" "68.86" "10" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "" "RAC1 GTPase cycle" "1" "0" "0.980" "0.867" "1.023" "1.014" "0.898" "1.005" "1.051" "0.811" "0.936" "1452.3" "1423.1" "1258.6" "1485.2" "1472.7" "1304.3" "1459.8" "1526.0" "1177.7" "1359.9" "" "" "" "" "" "" "" "" "" "" "1452.3" "1204.0" "795.8" "1082.9" "1206.6" "1012.9" "1125.3" "1312.1" "919.3" "1222.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "57.957" "33" "7" "23" "7" "240" "26.7" "5.20" "90.42" "7" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "" "RHOD GTPase cycle" "1" "0" "0.976" "1.029" "0.986" "0.952" "1.040" "0.982" "0.989" "1.010" "1.038" "1621.3" "1583.0" "1667.8" "1598.4" "1544.3" "1686.3" "1592.9" "1602.7" "1638.0" "1683.1" "" "" "" "" "" "" "" "" "" "" "1621.3" "1339.3" "1054.6" "1165.5" "1265.2" "1309.5" "1227.8" "1378.0" "1278.6" "1513.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "57.950" "42" "9" "31" "9" "224" "25.0" "6.38" "96.97" "9" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "5" "0" "0.967" "1.032" "0.990" "0.978" "1.009" "0.973" "1.010" "0.993" "1.064" "1748.7" "1691.5" "1804.4" "1730.9" "1710.5" "1763.7" "1702.0" "1766.5" "1735.7" "1860.8" "" "" "" "" "" "" "" "" "" "" "1748.7" "1431.1" "1140.9" "1262.1" "1401.4" "1369.7" "1311.9" "1518.8" "1354.8" "1672.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "57.923" "22" "11" "21" "11" "525" "58.2" "6.92" "65.61" "11" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "1.082" "1.108" "1.066" "1.052" "1.046" "1.027" "1.055" "1.131" "1.082" "926.2" "1002.4" "1025.8" "987.7" "974.0" "968.9" "951.3" "976.8" "1047.5" "1002.4" "" "" "" "" "" "" "" "" "" "" "926.2" "848.0" "648.6" "720.1" "798.0" "752.5" "733.3" "839.9" "817.7" "901.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "57.913" "27" "6" "30" "6" "204" "23.2" "5.11" "99.98" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "12" "0" "0.981" "1.103" "0.967" "0.979" "1.095" "1.067" "1.005" "1.007" "1.015" "2225.1" "2183.8" "2454.8" "2152.5" "2177.5" "2437.1" "2373.4" "2235.8" "2241.1" "2257.9" "" "" "" "" "" "" "" "" "" "" "2225.1" "1847.5" "1552.2" "1569.5" "1784.0" "1892.6" "1829.5" "1922.4" "1749.3" "2030.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "57.873" "14" "12" "23" "12" "950" "108.5" "7.47" "73.37" "12" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "mRNA processing" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "0.991" "1.087" "1.032" "0.957" "1.071" "1.020" "0.995" "1.092" "0.952" "1075.2" "1065.5" "1168.3" "1109.1" "1029.0" "1151.5" "1096.3" "1070.1" "1174.0" "1023.2" "" "" "" "" "" "" "" "" "" "" "1075.2" "901.4" "738.7" "808.7" "843.0" "894.3" "845.1" "920.1" "916.4" "919.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "57.744" "28" "8" "14" "8" "352" "39.9" "4.53" "54.52" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "0.923" "0.877" "1.043" "0.988" "0.966" "1.127" "1.036" "0.804" "0.901" "781.5" "721.7" "685.0" "814.8" "772.2" "754.9" "881.1" "810.0" "628.6" "703.8" "" "" "" "" "" "" "" "" "" "" "781.5" "610.6" "433.1" "594.1" "632.7" "586.3" "679.2" "696.4" "490.6" "632.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "57.728" "61" "8" "26" "8" "170" "18.7" "5.03" "91.37" "8" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.998" "1.137" "1.035" "1.088" "1.195" "1.183" "1.009" "1.151" "1.144" "812.6" "811.0" "924.1" "841.3" "884.5" "970.7" "961.6" "819.7" "935.6" "929.8" "" "" "" "" "" "" "" "" "" "" "812.6" "686.1" "584.3" "613.4" "724.6" "753.8" "741.2" "704.8" "730.3" "835.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.000" "False" "57.725" "13" "11" "13" "11" "1164" "126.5" "6.39" "51.82" "11" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.106" "0.935" "1.125" "1.095" "0.956" "1.111" "1.058" "0.912" "0.988" "351.2" "388.5" "328.4" "395.1" "384.4" "335.8" "390.0" "371.6" "320.2" "346.9" "" "" "" "" "" "" "" "" "" "" "351.2" "328.7" "207.6" "288.1" "315.0" "260.8" "300.7" "319.5" "249.9" "311.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "57.689" "26" "7" "15" "7" "399" "44.5" "5.05" "58.71" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.047" "1.059" "1.095" "1.079" "1.076" "1.029" "1.083" "1.041" "1.042" "692.4" "724.9" "733.5" "758.3" "747.1" "745.2" "712.4" "749.6" "720.7" "721.2" "" "" "" "" "" "" "" "" "" "" "692.4" "613.3" "463.8" "552.9" "612.1" "578.7" "549.1" "644.5" "562.6" "648.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "57.676" "32" "8" "18" "8" "333" "35.1" "8.38" "66.55" "8" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "" "Respiratory electron transport" "1" "0" "0.976" "0.964" "1.021" "0.998" "0.975" "0.953" "0.970" "0.979" "1.049" "1772.8" "1729.7" "1708.5" "1809.7" "1768.8" "1729.2" "1690.2" "1718.8" "1735.9" "1859.2" "" "" "" "" "" "" "" "" "" "" "1772.8" "1463.3" "1080.3" "1319.6" "1449.2" "1342.9" "1302.9" "1477.8" "1354.9" "1671.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7983353042055504763" "False" "High" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "0.000" "False" "57.634" "19" "11" "14" "11" "724" "79.3" "6.55" "48.96" "11" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "1.041" "0.878" "1.019" "1.010" "0.874" "1.103" "1.026" "0.852" "0.954" "617.9" "642.9" "542.4" "629.4" "624.0" "539.8" "681.4" "634.0" "526.5" "589.5" "" "" "" "" "" "" "" "" "" "" "617.9" "543.9" "342.9" "458.9" "511.2" "419.2" "525.3" "545.1" "410.9" "530.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "57.571" "17" "13" "20" "13" "826" "92.2" "7.90" "60.35" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "4" "0" "1.113" "1.112" "1.055" "1.046" "1.136" "1.123" "1.106" "1.053" "1.085" "429.6" "478.2" "477.7" "453.3" "449.3" "488.1" "482.6" "475.2" "452.2" "466.0" "" "" "" "" "" "" "" "" "" "" "429.6" "404.6" "302.1" "330.5" "368.1" "379.0" "372.0" "408.6" "353.0" "418.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "57.554" "20" "12" "18" "1" "564" "60.0" "8.00" "58.47" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "" "Formation of the cornified envelope" "2" "0" "0.469" "0.501" "0.339" "0.281" "0.594" "0.841" "0.291" "0.496" "0.305" "103.9" "48.7" "52.0" "35.2" "29.2" "61.7" "87.4" "30.3" "51.5" "31.7" "" "" "" "" "" "" "" "" "" "" "103.9" "41.2" "32.9" "25.7" "23.9" "47.9" "67.4" "26.0" "40.2" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "57.479" "34" "10" "23" "10" "306" "33.7" "5.08" "71.31" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "mRNA processing" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "6" "0" "1.100" "1.195" "0.967" "0.961" "1.125" "1.015" "1.029" "1.196" "1.085" "675.2" "742.5" "806.6" "653.0" "648.9" "759.8" "685.2" "694.8" "807.4" "732.5" "" "" "" "" "" "" "" "" "" "" "675.2" "628.2" "510.0" "476.1" "531.6" "590.0" "528.2" "597.4" "630.3" "658.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "57.418" "9" "10" "16" "10" "1132" "119.3" "5.60" "54.78" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.057" "0.880" "1.021" "1.248" "0.901" "0.998" "0.969" "0.888" "0.950" "633.4" "669.8" "557.6" "646.8" "790.6" "570.5" "632.5" "613.9" "562.5" "602.0" "" "" "" "" "" "" "" "" "" "" "633.4" "566.7" "352.6" "471.6" "647.8" "443.1" "487.5" "527.8" "439.0" "541.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "57.408" "47" "6" "34" "3" "147" "16.5" "7.93" "94.14" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "19" "5" "0.961" "1.096" "1.020" "0.956" "1.079" "1.050" "0.987" "1.031" "1.057" "739.0" "710.3" "809.6" "753.8" "706.7" "797.5" "775.7" "729.0" "762.1" "780.8" "" "" "" "" "" "" "" "" "" "" "739.0" "600.9" "511.9" "549.6" "579.0" "619.3" "597.9" "626.8" "594.9" "702.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "57.407" "32" "11" "24" "8" "381" "43.0" "5.35" "79.50" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "0" "0.989" "0.958" "1.012" "1.042" "0.936" "1.056" "1.038" "0.996" "1.089" "934.5" "924.1" "895.5" "945.5" "973.5" "874.8" "986.9" "970.4" "930.5" "1017.5" "" "" "" "" "" "" "" "" "" "" "934.5" "781.8" "566.2" "689.4" "797.6" "679.4" "760.8" "834.3" "726.4" "914.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "57.386" "15" "15" "18" "15" "1042" "117.7" "6.52" "60.20" "15" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.043" "1.013" "1.002" "0.997" "1.044" "0.963" "1.016" "1.039" "0.980" "1576.5" "1644.8" "1596.5" "1579.4" "1571.2" "1645.9" "1517.8" "1602.2" "1637.6" "1545.7" "" "" "" "" "" "" "" "" "" "" "1576.5" "1391.5" "1009.5" "1151.6" "1287.3" "1278.2" "1170.0" "1377.6" "1278.2" "1389.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "57.241" "24" "10" "20" "10" "529" "57.8" "5.40" "74.27" "10" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "8" "0" "1.062" "0.861" "1.095" "0.979" "0.930" "1.043" "1.052" "0.931" "1.008" "842.3" "894.6" "725.0" "922.1" "825.0" "783.2" "878.6" "886.1" "784.6" "849.3" "" "" "" "" "" "" "" "" "" "" "842.3" "756.8" "458.4" "672.3" "675.9" "608.2" "677.3" "761.8" "612.4" "763.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "57.055" "15" "12" "19" "12" "838" "90.3" "5.05" "57.65" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "4p16.3 copy number variation" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "3" "0" "0.983" "0.935" "1.098" "1.040" "0.929" "1.096" "1.040" "0.885" "1.023" "677.1" "665.7" "633.2" "743.7" "704.4" "628.9" "742.2" "704.1" "599.0" "692.7" "" "" "" "" "" "" "" "" "" "" "677.1" "563.2" "400.4" "542.2" "577.1" "488.4" "572.1" "605.4" "467.5" "622.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "56.948" "29" "10" "20" "8" "389" "44.8" "5.38" "67.89" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "8" "2" "0.976" "0.952" "1.017" "0.982" "1.009" "1.063" "1.036" "0.961" "0.908" "1007.4" "983.4" "958.6" "1024.8" "989.6" "1016.7" "1071.0" "1043.3" "967.6" "914.3" "" "" "" "" "" "" "" "" "" "" "1007.4" "832.0" "606.1" "747.2" "810.8" "789.5" "825.6" "897.0" "755.3" "822.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "56.724" "30" "8" "21" "8" "330" "37.6" "6.42" "66.58" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "0.980" "0.957" "1.011" "1.014" "0.959" "1.036" "1.002" "0.889" "1.009" "973.2" "953.7" "931.5" "983.7" "986.7" "933.5" "1008.2" "975.5" "865.0" "981.7" "" "" "" "" "" "" "" "" "" "" "973.2" "806.9" "589.0" "717.3" "808.4" "724.9" "777.2" "838.8" "675.2" "882.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "56.721" "42" "10" "24" "10" "261" "29.7" "7.05" "76.32" "10" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "17q12 copy number variation syndrome" "" "1" "0" "0.959" "1.109" "0.994" "0.952" "1.047" "1.108" "0.940" "0.999" "0.987" "1203.6" "1154.5" "1335.2" "1196.8" "1146.2" "1260.4" "1334.2" "1131.7" "1202.5" "1188.0" "" "" "" "" "" "" "" "" "" "" "1203.6" "976.7" "844.3" "872.6" "939.1" "978.8" "1028.4" "973.1" "938.6" "1068.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8565814559741767915" "False" "High" "IsMasterProtein" "Q16566" "Calcium/calmodulin-dependent protein kinase type IV OS=Homo sapiens OX=9606 GN=CAMK4 PE=1 SV=1" "0.000" "False" "56.706" "25" "10" "13" "10" "473" "51.9" "5.82" "45.26" "10" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "814" "ENSG00000152495" "CAMK4" "D3DSZ7; hsa:814; Q16566" "Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Hippocampal synaptogenesis and neurogenesis; Calcium regulation in cardiac cells" "Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308" "17" "0" "1.044" "0.970" "0.985" "0.931" "0.931" "0.939" "1.000" "0.905" "0.926" "615.9" "642.8" "597.4" "606.4" "573.3" "573.7" "578.5" "615.9" "557.4" "570.2" "" "" "" "" "" "" "" "" "" "" "615.9" "543.8" "377.8" "442.1" "469.7" "445.5" "445.9" "529.5" "435.1" "512.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "56.636" "39" "7" "18" "7" "208" "24.2" "10.32" "66.42" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.944" "1.040" "0.946" "0.997" "1.093" "0.999" "1.120" "1.130" "1.034" "927.4" "875.5" "964.5" "877.6" "924.6" "1013.9" "926.6" "1038.8" "1047.6" "958.8" "" "" "" "" "" "" "" "" "" "" "927.4" "740.7" "609.8" "639.9" "757.5" "787.4" "714.3" "893.1" "817.7" "862.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "56.576" "44" "12" "20" "12" "317" "35.1" "7.69" "72.53" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "10" "0" "1.008" "1.111" "1.034" "0.975" "1.119" "1.040" "1.086" "1.248" "1.032" "1408.2" "1419.0" "1565.2" "1456.5" "1373.2" "1575.3" "1463.9" "1529.3" "1757.2" "1453.3" "" "" "" "" "" "" "" "" "" "" "1408.2" "1200.5" "989.7" "1062.0" "1125.1" "1223.4" "1128.4" "1314.9" "1371.6" "1306.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "56.523" "10" "6" "57" "1" "630" "70.8" "5.60" "171.30" "6" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "56.520" "6" "12" "14" "12" "2002" "224.2" "5.55" "48.05" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "1.113" "0.988" "1.039" "1.084" "1.048" "1.091" "1.123" "1.039" "0.976" "428.9" "477.2" "423.6" "445.8" "464.9" "449.5" "468.1" "481.5" "445.6" "418.4" "" "" "" "" "" "" "" "" "" "" "428.9" "403.8" "267.9" "325.1" "380.9" "349.1" "360.8" "414.0" "347.8" "376.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465801585106187641" "False" "High" "IsMasterProtein" "P52735" "Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2" "0.000" "False" "56.444" "16" "14" "22" "14" "878" "101.2" "7.08" "70.51" "14" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "7410" "ENSG00000160293" "VAV2" "A2RUM4; A8MQ12; B6ZDF5; hsa:7410; P52735; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317" "Integrin-mediated cell adhesion; Prolactin signaling pathway; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Focal adhesion; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Ebola virus infection in host; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; GDNF signaling" "EPH-ephrin mediated repulsion of cells; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; Signal transduction by L1; Azathioprine ADME; VEGFR2 mediated vascular permeability" "34" "0" "1.017" "0.888" "1.009" "1.008" "0.905" "0.938" "1.036" "0.893" "0.959" "1427.9" "1452.2" "1267.6" "1441.1" "1439.9" "1292.1" "1339.0" "1479.3" "1275.5" "1369.1" "" "" "" "" "" "" "" "" "" "" "1427.9" "1228.6" "801.5" "1050.7" "1179.7" "1003.4" "1032.2" "1271.9" "995.6" "1230.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "56.412" "14" "11" "15" "11" "717" "82.9" "8.12" "56.39" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.051" "1.364" "1.028" "1.013" "1.304" "1.061" "1.071" "1.378" "1.095" "753.2" "791.9" "1027.0" "774.1" "762.8" "982.5" "798.7" "806.4" "1037.7" "824.6" "" "" "" "" "" "" "" "" "" "" "753.2" "669.9" "649.4" "564.4" "624.9" "763.0" "615.7" "693.4" "810.0" "741.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "56.288" "32" "10" "31" "10" "300" "34.3" "7.36" "87.88" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.992" "1.064" "0.970" "0.979" "1.019" "0.982" "0.990" "1.010" "0.980" "1876.7" "1861.2" "1995.9" "1819.5" "1837.7" "1912.8" "1842.1" "1858.8" "1895.4" "1839.3" "" "" "" "" "" "" "" "" "" "" "1876.7" "1574.6" "1262.0" "1326.7" "1505.6" "1485.5" "1419.9" "1598.2" "1479.5" "1653.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "56.241" "18" "16" "19" "16" "882" "97.5" "6.21" "58.98" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "13" "0" "1.040" "1.018" "1.127" "1.061" "1.033" "1.123" "1.083" "1.048" "1.054" "1081.8" "1125.5" "1101.8" "1219.0" "1148.3" "1117.2" "1215.4" "1171.5" "1134.0" "1140.2" "" "" "" "" "" "" "" "" "" "" "1081.8" "952.2" "696.6" "888.8" "940.8" "867.6" "936.9" "1007.2" "885.2" "1025.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "56.237" "37" "7" "15" "7" "219" "24.3" "4.94" "58.74" "7" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "0.947" "1.024" "0.953" "0.905" "1.014" "0.964" "0.944" "0.969" "0.970" "1189.0" "1125.6" "1217.9" "1132.6" "1076.2" "1205.1" "1146.3" "1122.2" "1152.2" "1153.3" "" "" "" "" "" "" "" "" "" "" "1189.0" "952.3" "770.1" "825.8" "881.7" "935.9" "883.6" "964.9" "899.4" "1036.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "56.218" "17" "12" "15" "12" "718" "81.0" "7.30" "52.34" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.136" "0.850" "1.129" "1.015" "0.855" "1.021" "1.049" "0.869" "0.976" "517.2" "587.3" "439.5" "583.8" "525.0" "442.3" "528.0" "542.6" "449.7" "505.0" "" "" "" "" "" "" "" "" "" "" "517.2" "496.9" "277.9" "425.7" "430.1" "343.5" "407.0" "466.5" "351.0" "454.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "56.216" "58" "8" "44" "8" "142" "15.9" "5.67" "133.61" "8" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "" "Neutrophil degranulation" "1" "0" "0.999" "1.135" "1.009" "0.933" "1.013" "0.930" "0.918" "1.011" "0.918" "2802.0" "2800.1" "3179.0" "2826.8" "2614.2" "2837.5" "2607.1" "2571.4" "2833.6" "2572.3" "" "" "" "" "" "" "" "" "" "" "2802.0" "2368.9" "2010.1" "2061.1" "2141.8" "2203.5" "2009.6" "2210.9" "2211.8" "2312.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "56.077" "32" "9" "41" "6" "249" "28.6" "4.09" "131.66" "9" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "IL-18 signaling pathway" "HuR (ELAVL1) binds and stabilizes mRNA" "2" "3" "0.980" "1.125" "1.006" "0.970" "0.996" "0.958" "0.952" "1.053" "1.094" "1823.6" "1787.6" "2050.7" "1834.7" "1768.7" "1817.0" "1746.6" "1735.7" "1920.0" "1994.6" "" "" "" "" "" "" "" "" "" "" "1823.6" "1512.4" "1296.7" "1337.8" "1449.1" "1411.0" "1346.4" "1492.3" "1498.7" "1793.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "56.021" "13" "13" "17" "13" "972" "112.2" "6.64" "56.68" "13" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "1.079" "1.087" "1.011" "1.250" "1.067" "1.002" "1.056" "1.050" "1.068" "1200.4" "1294.8" "1304.8" "1213.4" "1500.9" "1281.3" "1202.8" "1267.5" "1260.3" "1281.5" "" "" "" "" "" "" "" "" "" "" "1200.4" "1095.4" "825.0" "884.8" "1229.7" "995.0" "927.2" "1089.8" "983.7" "1152.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "55.928" "41" "6" "37" "3" "152" "17.1" "6.19" "115.67" "6" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "4" "0" "0.946" "1.090" "1.014" "0.957" "1.055" "0.953" "0.955" "1.005" "0.943" "1221.0" "1154.8" "1331.3" "1237.9" "1168.4" "1288.0" "1163.1" "1166.4" "1227.0" "1151.4" "" "" "" "" "" "" "" "" "" "" "1221.0" "977.0" "841.8" "902.6" "957.3" "1000.2" "896.6" "1002.9" "957.8" "1035.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "55.852" "13" "11" "18" "11" "981" "110.5" "5.55" "58.75" "11" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "0.985" "0.941" "1.005" "1.011" "0.932" "0.985" "1.060" "0.910" "0.969" "825.6" "812.9" "776.9" "829.3" "834.3" "769.1" "813.5" "875.5" "751.7" "800.3" "" "" "" "" "" "" "" "" "" "" "825.6" "687.7" "491.3" "604.7" "683.5" "597.2" "627.1" "752.7" "586.7" "719.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "55.745" "41" "11" "18" "9" "301" "33.9" "8.38" "60.54" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "15" "2" "1.033" "1.121" "1.059" "1.054" "1.088" "1.064" "1.016" "1.081" "1.075" "713.8" "737.4" "800.5" "756.1" "752.5" "776.6" "759.1" "725.4" "771.4" "767.0" "" "" "" "" "" "" "" "" "" "" "713.8" "623.8" "506.1" "551.3" "616.5" "603.1" "585.2" "623.7" "602.1" "689.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "55.653" "33" "10" "25" "10" "309" "34.5" "8.98" "75.96" "10" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.057" "0.862" "1.024" "1.060" "0.871" "1.016" "1.032" "0.894" "0.967" "1584.5" "1674.5" "1365.4" "1622.0" "1679.3" "1379.9" "1609.3" "1634.8" "1417.3" "1531.5" "" "" "" "" "" "" "" "" "" "" "1584.5" "1416.7" "863.4" "1182.6" "1375.9" "1071.6" "1240.5" "1405.6" "1106.3" "1376.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "55.589" "23" "7" "20" "7" "380" "41.8" "8.54" "67.76" "7" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.062" "1.092" "1.103" "1.020" "1.094" "1.021" "0.966" "1.092" "1.057" "744.9" "790.7" "813.5" "821.6" "759.9" "815.2" "760.5" "719.6" "813.4" "787.4" "" "" "" "" "" "" "" "" "" "" "744.9" "669.0" "514.4" "599.1" "622.6" "633.0" "586.2" "618.7" "634.9" "707.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "55.581" "27" "12" "17" "7" "499" "55.7" "5.62" "53.55" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "4" "3" "0.988" "0.935" "0.937" "0.928" "0.911" "0.977" "0.961" "0.875" "0.881" "1032.3" "1019.7" "965.5" "967.7" "958.0" "940.9" "1008.7" "992.5" "903.5" "909.3" "" "" "" "" "" "" "" "" "" "" "1032.3" "862.7" "610.5" "705.6" "784.9" "730.7" "777.5" "853.3" "705.2" "817.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "55.502" "16" "14" "16" "13" "917" "102.4" "6.80" "49.18" "14" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "12" "0" "1.056" "1.167" "1.121" "1.103" "1.208" "1.107" "1.090" "1.139" "1.123" "779.9" "823.7" "910.2" "874.2" "860.1" "942.1" "863.2" "850.3" "888.4" "876.1" "" "" "" "" "" "" "" "" "" "" "779.9" "696.9" "575.5" "637.4" "704.7" "731.6" "665.4" "731.1" "693.4" "787.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "55.490" "11" "10" "15" "10" "1067" "117.8" "6.40" "46.40" "10" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "0.813" "1.005" "0.853" "0.822" "0.803" "0.733" "0.855" "0.913" "0.888" "292.5" "237.9" "293.8" "249.6" "240.5" "234.9" "214.4" "250.1" "266.9" "259.7" "" "" "" "" "" "" "" "" "" "" "292.5" "201.2" "185.8" "182.0" "197.0" "182.4" "165.3" "215.1" "208.3" "233.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "55.487" "34" "11" "17" "11" "360" "41.5" "4.91" "46.90" "11" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "2q37 copy number variation syndrome" "" "1" "0" "1.065" "1.148" "1.102" "1.035" "1.153" "0.994" "1.000" "1.194" "1.127" "446.2" "475.2" "512.1" "491.8" "462.0" "514.3" "443.7" "446.2" "532.8" "502.7" "" "" "" "" "" "" "" "" "" "" "446.2" "402.1" "323.8" "358.6" "378.5" "399.4" "342.1" "383.7" "415.9" "451.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "55.486" "13" "9" "23" "8" "707" "76.1" "9.44" "74.24" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "mRNA processing; Type 2 papillary renal cell carcinoma" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "4" "0" "1.164" "1.338" "0.967" "1.121" "1.504" "0.991" "0.971" "1.323" "1.142" "1409.2" "1640.6" "1885.2" "1363.1" "1579.3" "2118.9" "1396.3" "1368.0" "1864.4" "1609.4" "" "" "" "" "" "" "" "" "" "" "1409.2" "1388.0" "1192.0" "993.9" "1293.9" "1645.5" "1076.4" "1176.2" "1455.3" "1447.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "55.243" "17" "14" "18" "14" "837" "91.7" "5.76" "57.08" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "0.970" "0.804" "1.067" "1.024" "0.802" "1.006" "1.034" "0.777" "0.935" "555.5" "538.7" "446.8" "592.9" "569.1" "445.6" "559.1" "574.7" "431.8" "519.3" "" "" "" "" "" "" "" "" "" "" "555.5" "455.8" "282.5" "432.3" "466.2" "346.0" "431.0" "494.1" "337.0" "466.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "55.243" "11" "12" "16" "12" "1523" "161.8" "4.83" "46.08" "12" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "1.039" "0.922" "1.098" "1.110" "1.010" "1.110" "1.091" "0.999" "1.055" "499.2" "518.7" "460.1" "548.2" "554.3" "504.5" "554.0" "544.4" "498.9" "526.9" "" "" "" "" "" "" "" "" "" "" "499.2" "438.8" "291.0" "399.7" "454.2" "391.8" "427.0" "468.1" "389.4" "473.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "55.202" "6" "13" "17" "9" "2542" "269.3" "5.73" "57.57" "13" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "3" "1.013" "0.837" "1.015" "1.027" "0.805" "1.038" "1.018" "0.823" "0.934" "985.3" "997.8" "825.2" "999.9" "1012.4" "793.6" "1022.9" "1003.4" "810.8" "920.4" "" "" "" "" "" "" "" "" "" "" "985.3" "844.2" "521.8" "729.1" "829.5" "616.3" "788.5" "862.7" "632.9" "827.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.000" "False" "55.197" "15" "12" "15" "12" "970" "106.6" "5.72" "50.19" "12" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "" "CDC42 GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle" "3" "0" "1.010" "0.905" "0.963" "0.897" "0.862" "0.988" "0.967" "0.863" "0.914" "718.8" "725.9" "650.7" "692.1" "644.7" "619.6" "710.4" "695.1" "620.4" "657.1" "" "" "" "" "" "" "" "" "" "" "718.8" "614.1" "411.5" "504.6" "528.2" "481.2" "547.6" "597.6" "484.3" "590.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "54.999" "17" "7" "12" "7" "499" "55.4" "5.78" "42.26" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "" "mRNA Splicing - Major Pathway" "1" "0" "0.993" "0.838" "0.932" "0.943" "0.922" "0.973" "1.006" "0.914" "0.889" "429.3" "426.4" "359.8" "399.9" "404.8" "395.7" "417.9" "431.7" "392.3" "381.5" "" "" "" "" "" "" "" "" "" "" "429.3" "360.7" "227.5" "291.6" "331.6" "307.3" "322.1" "371.1" "306.2" "343.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "54.948" "16" "11" "17" "11" "798" "87.1" "5.31" "56.34" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "VEGFA-VEGFR2 signaling" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "3" "0" "1.015" "1.152" "0.993" "0.994" "1.232" "1.022" "1.003" "1.194" "1.096" "748.2" "759.1" "862.0" "743.1" "743.5" "922.1" "764.4" "750.6" "892.9" "820.2" "" "" "" "" "" "" "" "" "" "" "748.2" "642.2" "545.1" "541.9" "609.1" "716.1" "589.3" "645.4" "697.0" "737.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "54.903" "45" "5" "15" "5" "153" "16.9" "6.60" "64.74" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "" "2" "0" "1.115" "0.907" "1.096" "1.161" "1.039" "1.320" "1.071" "0.924" "1.120" "390.2" "435.0" "353.7" "427.6" "453.1" "405.3" "514.9" "417.8" "360.5" "436.8" "" "" "" "" "" "" "" "" "" "" "390.2" "368.1" "223.6" "311.8" "371.2" "314.7" "396.9" "359.3" "281.4" "392.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "54.789" "39" "10" "13" "10" "296" "31.7" "6.55" "48.46" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "1.039" "1.028" "1.106" "1.068" "1.013" "1.035" "1.007" "1.084" "1.017" "498.1" "517.6" "512.0" "551.0" "531.8" "504.8" "515.4" "501.4" "540.0" "506.8" "" "" "" "" "" "" "" "" "" "" "498.1" "437.9" "323.7" "401.8" "435.7" "392.0" "397.3" "431.1" "421.5" "455.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "54.727" "42" "7" "22" "7" "206" "22.2" "5.36" "79.77" "7" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "0.963" "0.883" "1.041" "1.027" "0.940" "1.115" "0.980" "0.807" "0.988" "1062.4" "1022.9" "938.4" "1106.5" "1091.4" "998.7" "1184.9" "1041.4" "857.4" "1050.2" "" "" "" "" "" "" "" "" "" "" "1062.4" "865.4" "593.4" "806.8" "894.2" "775.5" "913.4" "895.4" "669.3" "944.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "54.566" "40" "6" "10" "6" "204" "22.6" "9.45" "39.21" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "TAR syndrome" "" "1" "0" "0.911" "0.972" "0.921" "0.956" "1.089" "1.098" "0.908" "0.945" "1.019" "502.9" "458.4" "489.1" "463.2" "480.6" "547.6" "552.1" "456.6" "475.1" "512.4" "" "" "" "" "" "" "" "" "" "" "502.9" "387.8" "309.3" "337.7" "393.7" "425.2" "425.6" "392.6" "370.8" "460.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "54.505" "23" "8" "17" "8" "357" "38.3" "7.97" "57.40" "8" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Disorders of fructose metabolism; Polyol pathway" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "4" "0" "1.054" "1.076" "1.120" "1.026" "1.067" "1.053" "1.097" "1.103" "1.088" "813.0" "856.8" "874.7" "910.6" "834.3" "867.6" "855.7" "891.8" "896.5" "884.5" "" "" "" "" "" "" "" "" "" "" "813.0" "724.8" "553.1" "663.9" "683.5" "673.7" "659.6" "766.7" "699.7" "795.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "54.501" "12" "15" "18" "15" "1299" "150.0" "5.54" "58.24" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.956" "0.977" "0.999" "1.045" "1.016" "1.039" "1.109" "0.948" "0.914" "872.9" "834.7" "853.0" "871.7" "912.6" "886.9" "907.2" "967.7" "827.9" "797.9" "" "" "" "" "" "" "" "" "" "" "872.9" "706.2" "539.3" "635.6" "747.7" "688.7" "699.3" "832.0" "646.2" "717.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "54.458" "19" "12" "18" "12" "699" "73.6" "9.47" "56.52" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "1.200" "1.604" "1.108" "1.203" "1.883" "1.065" "1.012" "1.780" "1.286" "667.5" "801.1" "1070.7" "739.4" "802.9" "1257.2" "711.2" "675.5" "1188.2" "858.6" "" "" "" "" "" "" "" "" "" "" "667.5" "677.7" "677.0" "539.2" "657.9" "976.3" "548.2" "580.8" "927.4" "771.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "54.437" "41" "9" "17" "9" "227" "25.6" "9.16" "57.96" "9" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "1.021" "1.132" "1.039" "1.032" "1.059" "1.010" "1.030" "1.064" "1.045" "875.0" "893.5" "990.7" "909.4" "902.9" "926.3" "883.8" "900.9" "930.9" "914.7" "" "" "" "" "" "" "" "" "" "" "875.0" "755.9" "626.4" "663.1" "739.8" "719.3" "681.3" "774.6" "726.6" "822.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469585503029869905" "False" "High" "IsMasterProtein" "Q96PU5" "E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2" "0.000" "False" "54.304" "13" "13" "18" "12" "975" "111.9" "5.82" "54.67" "13" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "23327" "ENSG00000049759" "NEDD4L" "hsa:23327; O43165; Q3LSM7; Q7Z5F1; Q7Z5F2; Q7Z5N3; Q8N5A7; Q8WUU9; Q96PU5; Q9BW58; Q9H2W4; Q9NT88" "TGF-beta signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Stimuli-sensing channels; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "6" "1" "1.077" "0.985" "1.087" "1.106" "0.959" "1.091" "1.106" "1.019" "1.096" "865.9" "932.6" "852.9" "941.3" "957.6" "830.4" "944.9" "957.9" "882.8" "949.1" "" "" "" "" "" "" "" "" "" "" "865.9" "789.0" "539.3" "686.3" "784.5" "644.8" "728.4" "823.6" "689.0" "853.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "54.185" "35" "9" "24" "9" "258" "29.0" "4.83" "72.27" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.978" "1.116" "1.009" "1.055" "1.183" "1.158" "0.977" "1.054" "1.066" "1845.0" "1804.6" "2058.1" "1862.2" "1947.2" "2182.7" "2136.7" "1802.0" "1945.3" "1966.2" "" "" "" "" "" "" "" "" "" "" "1845.0" "1526.7" "1301.3" "1357.8" "1595.4" "1695.1" "1647.1" "1549.3" "1518.5" "1767.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "54.142" "19" "11" "14" "11" "626" "72.2" "7.14" "49.84" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "" "Interferon alpha/beta signaling; Nucleotide catabolism" "2" "0" "1.016" "0.874" "1.113" "1.010" "0.879" "1.059" "1.010" "0.910" "1.000" "655.7" "666.0" "572.8" "729.9" "662.2" "576.1" "694.5" "662.0" "596.9" "655.5" "" "" "" "" "" "" "" "" "" "" "655.7" "563.4" "362.2" "532.2" "542.6" "447.4" "535.3" "569.2" "465.9" "589.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "54.114" "40" "9" "23" "9" "235" "26.4" "5.64" "76.95" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "1.049" "1.040" "1.025" "1.049" "1.123" "1.022" "1.041" "1.049" "1.013" "1502.6" "1575.9" "1562.9" "1539.4" "1575.8" "1687.5" "1535.2" "1563.9" "1575.9" "1522.3" "" "" "" "" "" "" "" "" "" "" "1502.6" "1333.3" "988.3" "1122.4" "1291.0" "1310.5" "1183.4" "1344.7" "1230.1" "1368.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.000" "False" "54.040" "3" "16" "16" "16" "5596" "632.4" "5.68" "48.57" "16" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "1.063" "0.889" "1.107" "1.135" "0.866" "1.107" "1.097" "0.929" "0.986" "385.9" "410.1" "343.1" "427.3" "437.9" "334.2" "427.3" "423.4" "358.6" "380.4" "" "" "" "" "" "" "" "" "" "" "385.9" "347.0" "217.0" "311.6" "358.8" "259.5" "329.4" "364.1" "279.9" "342.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "54.018" "14" "14" "19" "9" "977" "107.5" "7.03" "56.51" "14" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "21" "3" "1.106" "1.253" "1.045" "1.078" "1.272" "1.076" "1.137" "1.275" "1.154" "731.1" "808.8" "916.1" "764.0" "788.3" "929.9" "786.5" "831.5" "931.9" "843.8" "" "" "" "" "" "" "" "" "" "" "731.1" "684.3" "579.2" "557.1" "645.9" "722.1" "606.3" "714.9" "727.4" "758.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "54.009" "16" "14" "18" "14" "1023" "115.9" "6.86" "52.44" "14" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "1.048" "1.041" "1.007" "1.050" "1.035" "1.000" "1.023" "0.997" "1.066" "778.6" "816.1" "810.3" "784.4" "817.4" "805.8" "778.3" "796.1" "776.7" "830.2" "" "" "" "" "" "" "" "" "" "" "778.6" "690.4" "512.3" "571.9" "669.7" "625.8" "600.0" "684.5" "606.2" "746.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "54.003" "11" "16" "17" "16" "1584" "175.2" "7.11" "52.20" "16" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "Ciliary landscape" "" "1" "0" "0.985" "0.957" "1.077" "1.079" "1.032" "1.086" "1.030" "1.041" "0.979" "948.3" "934.3" "907.2" "1021.6" "1023.5" "978.7" "1029.9" "976.9" "987.0" "928.2" "" "" "" "" "" "" "" "" "" "" "948.3" "790.5" "573.6" "744.9" "838.5" "760.0" "793.9" "840.0" "770.4" "834.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "54.000" "22" "11" "16" "11" "585" "64.9" "8.87" "50.77" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "" "3" "0" "1.033" "1.009" "0.988" "1.000" "0.980" "0.946" "1.001" "1.020" "1.027" "801.2" "827.5" "808.1" "791.2" "801.0" "785.0" "758.2" "801.9" "817.4" "823.2" "" "" "" "" "" "" "" "" "" "" "801.2" "700.1" "511.0" "576.9" "656.2" "609.6" "584.5" "689.5" "638.1" "740.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "53.953" "26" "8" "18" "8" "359" "38.4" "5.50" "61.15" "8" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "0.584" "0.665" "0.660" "0.584" "0.834" "0.599" "0.547" "0.898" "0.648" "1058.7" "618.8" "704.4" "698.8" "618.1" "883.0" "634.0" "578.7" "951.0" "686.0" "" "" "" "" "" "" "" "" "" "" "1058.7" "523.5" "445.4" "509.5" "506.4" "685.8" "488.7" "497.6" "742.3" "616.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "53.841" "19" "12" "17" "1" "564" "60.0" "8.00" "54.08" "12" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "Formation of the cornified envelope" "5" "3" "0.692" "0.453" "0.558" "0.500" "0.828" "1.021" "0.323" "0.624" "0.400" "494.2" "342.0" "224.0" "275.9" "247.3" "409.4" "504.7" "159.5" "308.2" "197.8" "" "" "" "" "" "" "" "" "" "" "494.2" "289.4" "141.6" "201.2" "202.6" "317.9" "389.1" "137.1" "240.6" "177.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "53.829" "24" "9" "20" "4" "429" "49.4" "6.81" "58.44" "9" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "22q11.2 copy number variation syndrome" "" "1" "0" "0.983" "0.933" "1.004" "1.029" "0.978" "1.037" "1.018" "1.086" "1.070" "358.8" "352.7" "334.9" "360.2" "369.3" "351.0" "371.9" "365.3" "389.8" "383.8" "" "" "" "" "" "" "" "" "" "" "358.8" "298.4" "211.8" "262.6" "302.5" "272.6" "286.7" "314.1" "304.2" "345.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "53.769" "17" "9" "14" "9" "588" "68.0" "7.33" "48.20" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.976" "0.841" "0.946" "0.969" "0.825" "0.999" "0.953" "0.820" "0.894" "930.0" "907.3" "781.8" "879.7" "901.4" "767.6" "929.4" "886.0" "762.6" "831.9" "" "" "" "" "" "" "" "" "" "" "930.0" "767.6" "494.3" "641.5" "738.5" "596.1" "716.4" "761.8" "595.3" "747.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "53.721" "34" "8" "23" "8" "295" "32.8" "4.87" "72.83" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.017" "1.295" "1.059" "1.095" "1.272" "1.228" "1.177" "1.276" "1.141" "921.6" "937.3" "1193.0" "975.5" "1009.0" "1172.6" "1131.8" "1084.6" "1175.8" "1051.2" "" "" "" "" "" "" "" "" "" "" "921.6" "793.0" "754.3" "711.3" "826.7" "910.6" "872.5" "932.5" "917.8" "945.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "53.562" "25" "6" "32" "3" "251" "28.8" "4.06" "101.28" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.991" "1.146" "0.999" "1.032" "0.991" "1.060" "0.980" "1.055" "1.069" "558.7" "553.9" "640.2" "558.1" "576.5" "553.5" "592.3" "547.3" "589.7" "597.0" "" "" "" "" "" "" "" "" "" "" "558.7" "468.6" "404.8" "406.9" "472.3" "429.9" "456.6" "470.6" "460.3" "536.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "53.515" "18" "9" "21" "5" "534" "60.6" "6.83" "71.78" "9" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Insulin signaling" "Factors involved in megakaryocyte development and platelet production" "2" "0" "1.050" "1.008" "1.064" "1.036" "1.057" "1.052" "1.033" "0.980" "1.083" "457.6" "480.3" "461.1" "486.9" "473.8" "483.5" "481.3" "472.9" "448.3" "495.5" "" "" "" "" "" "" "" "" "" "" "457.6" "406.3" "291.6" "355.0" "388.2" "375.5" "371.0" "406.6" "349.9" "445.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "53.512" "14" "7" "20" "5" "519" "57.5" "6.58" "75.29" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "1" "1.081" "0.890" "1.098" "1.151" "0.940" "1.157" "1.092" "0.900" "0.986" "1708.1" "1846.4" "1519.5" "1875.5" "1965.2" "1604.8" "1975.8" "1865.5" "1537.9" "1684.0" "" "" "" "" "" "" "" "" "" "" "1708.1" "1562.1" "960.8" "1367.5" "1610.1" "1246.3" "1523.0" "1604.0" "1200.4" "1514.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "53.511" "31" "12" "19" "11" "340" "38.0" "8.63" "61.01" "12" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "Nuclear receptors meta-pathway; NRF2 pathway" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "7" "1" "1.006" "1.006" "0.967" "0.995" "1.023" "0.981" "1.005" "0.979" "0.943" "1350.6" "1358.3" "1358.4" "1305.4" "1343.6" "1382.2" "1325.6" "1356.9" "1322.0" "1273.1" "" "" "" "" "" "" "" "" "" "" "1350.6" "1149.2" "858.9" "951.8" "1100.8" "1073.4" "1021.8" "1166.7" "1031.9" "1144.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "53.481" "11" "12" "16" "12" "1087" "123.8" "6.32" "55.11" "12" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "0.959" "0.985" "1.002" "1.014" "1.021" "0.992" "1.009" "1.022" "0.993" "1012.3" "970.7" "996.7" "1014.5" "1026.2" "1033.6" "1004.4" "1020.9" "1034.1" "1005.4" "" "" "" "" "" "" "" "" "" "" "1012.3" "821.2" "630.2" "739.7" "840.8" "802.6" "774.2" "877.8" "807.2" "903.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "53.335" "11" "11" "17" "11" "1151" "131.6" "4.98" "60.04" "11" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "0.991" "1.024" "1.049" "1.029" "1.006" "0.984" "0.989" "1.061" "1.100" "917.2" "909.0" "939.0" "961.9" "944.2" "922.6" "902.3" "907.1" "973.0" "1009.2" "" "" "" "" "" "" "" "" "" "" "917.2" "769.1" "593.7" "701.4" "773.6" "716.4" "695.5" "779.9" "759.5" "907.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "53.333" "32" "7" "12" "7" "277" "30.2" "5.26" "45.80" "7" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "0.994" "1.063" "1.042" "0.986" "1.076" "1.153" "1.017" "1.020" "0.993" "821.0" "815.9" "873.1" "855.2" "809.6" "883.6" "946.7" "834.8" "837.6" "815.5" "" "" "" "" "" "" "" "" "" "" "821.0" "690.2" "552.1" "623.6" "663.3" "686.2" "729.8" "717.8" "653.8" "733.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "53.324" "13" "11" "15" "11" "875" "100.6" "5.22" "49.30" "11" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.009" "0.892" "0.976" "1.003" "0.894" "0.985" "1.025" "0.901" "1.014" "1160.9" "1171.4" "1035.4" "1133.6" "1164.4" "1037.3" "1143.5" "1189.8" "1046.2" "1176.9" "" "" "" "" "" "" "" "" "" "" "1160.9" "991.1" "654.7" "826.5" "954.0" "805.5" "881.4" "1023.0" "816.6" "1058.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "53.294" "48" "6" "31" "3" "145" "16.4" "8.09" "85.19" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "1.043" "1.084" "1.056" "1.002" "1.071" "1.116" "0.976" "1.065" "1.036" "366.9" "382.8" "397.6" "387.4" "367.6" "393.2" "409.5" "358.2" "390.7" "380.1" "" "" "" "" "" "" "" "" "" "" "366.9" "323.9" "251.4" "282.4" "301.2" "305.3" "315.7" "308.0" "304.9" "341.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "53.291" "37" "10" "19" "10" "315" "37.1" "4.64" "60.93" "10" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "1.008" "1.007" "1.033" "1.010" "1.025" "1.201" "0.983" "1.006" "1.012" "758.7" "764.5" "764.0" "784.0" "766.3" "777.7" "911.0" "745.7" "763.6" "768.1" "" "" "" "" "" "" "" "" "" "" "758.7" "646.8" "483.1" "571.7" "627.8" "604.0" "702.2" "641.1" "596.0" "690.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "53.291" "25" "9" "14" "9" "392" "42.2" "6.46" "51.31" "9" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Disorders of galactose metabolism" "Galactose catabolism; Defective GALK1 causes GALCT2" "3" "0" "1.079" "0.999" "1.039" "1.085" "1.023" "1.106" "1.109" "1.031" "1.059" "700.7" "756.3" "700.0" "727.9" "760.2" "716.6" "775.2" "776.8" "722.4" "742.3" "" "" "" "" "" "" "" "" "" "" "700.7" "639.8" "442.6" "530.8" "622.8" "556.5" "597.6" "667.9" "563.9" "667.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3084811773954898757" "False" "High" "IsMasterProtein" "Q6BCY4" "NADH-cytochrome b5 reductase 2 OS=Homo sapiens OX=9606 GN=CYB5R2 PE=1 SV=1" "0.000" "False" "53.225" "35" "10" "21" "10" "276" "31.4" "8.50" "64.12" "10" "other metabolic processes;transport" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00175, Pf00970" "51700" "ENSG00000166394" "CYB5R2" "hsa:51700; Q6BCY4; Q9BVA3; Q9UF68; Q9UHJ0" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "0.991" "1.058" "1.012" "0.988" "1.108" "0.988" "0.953" "1.123" "1.059" "828.6" "821.3" "876.5" "838.6" "818.7" "918.1" "818.5" "789.7" "930.5" "877.6" "" "" "" "" "" "" "" "" "" "" "828.6" "694.8" "554.2" "611.5" "670.7" "713.0" "631.0" "679.0" "726.3" "789.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "53.223" "17" "13" "17" "13" "807" "89.4" "7.30" "55.06" "13" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "2" "0" "0.964" "0.941" "0.997" "0.979" "0.841" "0.965" "0.983" "0.859" "0.897" "977.3" "941.6" "919.9" "974.5" "956.5" "821.5" "942.7" "960.8" "839.5" "876.9" "" "" "" "" "" "" "" "" "" "" "977.3" "796.6" "581.6" "710.5" "783.7" "637.9" "726.7" "826.1" "655.3" "788.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "53.136" "25" "7" "19" "2" "309" "35.6" "5.54" "66.16" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "53" "0" "1.094" "1.084" "1.062" "1.029" "1.071" "1.087" "1.075" "1.040" "0.918" "275.5" "301.6" "298.8" "292.6" "283.5" "295.1" "299.5" "296.2" "286.5" "253.1" "" "" "" "" "" "" "" "" "" "" "275.5" "255.1" "188.9" "213.3" "232.2" "229.2" "230.9" "254.7" "223.6" "227.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "53.122" "26" "8" "14" "8" "344" "37.4" "6.24" "48.71" "8" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.015" "1.023" "1.046" "1.082" "1.027" "1.074" "1.021" "1.053" "1.021" "531.7" "539.7" "543.8" "555.9" "575.5" "546.0" "571.3" "542.7" "560.1" "542.7" "" "" "" "" "" "" "" "" "" "" "531.7" "456.6" "343.8" "405.4" "471.5" "424.0" "440.4" "466.6" "437.2" "487.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "53.058" "13" "14" "25" "3" "937" "104.5" "5.38" "79.13" "14" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "MHC class II antigen presentation; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; Recycling pathway of L1; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2" "20" "0" "1.112" "1.202" "1.111" "1.080" "1.254" "1.063" "1.166" "1.135" "1.136" "150.1" "166.9" "180.4" "166.7" "162.1" "188.2" "159.5" "175.0" "170.3" "170.5" "" "" "" "" "" "" "" "" "" "" "150.1" "141.2" "114.1" "121.5" "132.8" "146.1" "123.0" "150.5" "133.0" "153.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "53.047" "33" "6" "14" "6" "261" "29.8" "5.55" "54.38" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "1.002" "1.476" "1.017" "1.037" "1.567" "1.162" "0.991" "1.528" "1.246" "609.6" "610.8" "899.6" "619.8" "632.1" "955.0" "708.6" "604.2" "931.3" "759.3" "" "" "" "" "" "" "" "" "" "" "609.6" "516.7" "568.8" "452.0" "517.9" "741.6" "546.2" "519.5" "726.9" "682.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "52.820" "26" "8" "21" "7" "367" "40.5" "8.90" "87.61" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "Protein hydroxylation" "1" "1" "1.035" "0.944" "0.995" "0.999" "0.915" "0.993" "1.045" "0.904" "1.005" "1343.0" "1389.5" "1267.8" "1335.8" "1341.0" "1228.5" "1334.0" "1402.9" "1214.6" "1349.2" "" "" "" "" "" "" "" "" "" "" "1343.0" "1175.5" "801.7" "974.0" "1098.7" "954.1" "1028.3" "1206.2" "948.1" "1213.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "52.813" "25" "6" "28" "6" "290" "33.5" "4.32" "114.28" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "Histone modifications; VEGFA-VEGFR2 signaling" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "4" "0" "0.992" "1.055" "1.053" "1.039" "1.084" "1.074" "0.967" "1.211" "1.146" "1456.0" "1444.1" "1536.4" "1533.4" "1513.0" "1577.7" "1563.7" "1408.5" "1762.6" "1668.9" "" "" "" "" "" "" "" "" "" "" "1456.0" "1221.8" "971.5" "1118.1" "1239.6" "1225.2" "1205.4" "1211.0" "1375.8" "1500.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "52.724" "25" "7" "19" "2" "309" "35.6" "5.43" "65.91" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "45" "6" "1.001" "1.038" "0.957" "0.998" "1.104" "0.957" "1.004" "0.994" "1.035" "874.9" "875.7" "908.0" "837.7" "873.0" "965.5" "837.5" "878.8" "870.1" "905.7" "" "" "" "" "" "" "" "" "" "" "874.9" "740.9" "574.1" "610.8" "715.2" "749.8" "645.6" "755.6" "679.1" "814.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "52.720" "8" "10" "14" "10" "1306" "147.4" "6.15" "51.43" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "9" "0" "1.100" "1.124" "1.118" "1.082" "1.158" "1.093" "1.135" "1.112" "1.137" "721.2" "793.1" "810.8" "806.4" "780.0" "834.8" "788.0" "818.7" "801.8" "820.0" "" "" "" "" "" "" "" "" "" "" "721.2" "671.0" "512.7" "588.0" "639.1" "648.3" "607.4" "703.9" "625.8" "737.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "52.613" "23" "12" "15" "11" "623" "69.9" "5.67" "51.02" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "1" "1.056" "1.028" "1.043" "1.003" "1.077" "0.998" "1.030" "1.100" "1.052" "725.8" "766.1" "746.0" "757.0" "728.3" "781.5" "724.5" "747.5" "798.4" "763.3" "" "" "" "" "" "" "" "" "" "" "725.8" "648.2" "471.7" "552.0" "596.7" "606.9" "558.5" "642.7" "623.2" "686.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "52.597" "10" "11" "14" "8" "1294" "141.0" "8.40" "44.49" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "8" "0" "1.132" "1.109" "1.118" "1.218" "1.209" "1.235" "1.162" "1.112" "1.069" "299.2" "338.7" "331.8" "334.5" "364.4" "361.9" "369.5" "347.8" "332.7" "319.9" "" "" "" "" "" "" "" "" "" "" "299.2" "286.5" "209.8" "243.9" "298.6" "281.0" "284.8" "299.1" "259.7" "287.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "52.461" "53" "10" "20" "2" "205" "22.7" "6.21" "68.12" "10" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "7" "0.978" "1.154" "0.938" "0.935" "1.125" "0.967" "1.009" "1.117" "1.047" "1789.4" "1749.2" "2065.0" "1679.3" "1672.5" "2013.6" "1730.7" "1805.2" "1998.3" "1873.1" "" "" "" "" "" "" "" "" "" "" "1789.4" "1479.9" "1305.7" "1224.4" "1370.3" "1563.7" "1334.1" "1552.1" "1559.8" "1684.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "52.428" "33" "8" "38" "8" "216" "23.7" "9.41" "111.51" "8" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "4" "0" "0.974" "1.004" "0.929" "0.993" "0.963" "0.987" "0.967" "0.949" "0.968" "2507.6" "2443.7" "2516.6" "2330.2" "2491.0" "2416.1" "2474.3" "2425.1" "2380.6" "2426.2" "" "" "" "" "" "" "" "" "" "" "2507.6" "2067.4" "1591.3" "1699.1" "2040.9" "1876.3" "1907.3" "2085.1" "1858.2" "2181.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "52.393" "16" "11" "13" "11" "782" "84.8" "5.57" "46.14" "11" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "Focal adhesion" "" "1" "0" "0.991" "0.826" "1.137" "1.015" "0.837" "0.959" "1.015" "0.883" "0.999" "280.1" "277.5" "231.4" "318.6" "284.4" "234.6" "268.8" "284.4" "247.4" "280.0" "" "" "" "" "" "" "" "" "" "" "280.1" "234.8" "146.3" "232.3" "233.0" "182.2" "207.2" "244.5" "193.1" "251.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7906499553592381403" "False" "High" "IsMasterProtein" "Q7Z5L9" "Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2" "0.000" "False" "52.343" "24" "12" "13" "10" "587" "61.0" "8.69" "46.68" "12" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf11261" "359948" "ENSG00000168264" "IRF2BP2" "B1AM35; B1AM36; hsa:359948; Q6P083; Q7Z5L8; Q7Z5L9; Q8N351; Q8WUH8" "" "" "0" "2" "1.006" "0.916" "0.989" "1.021" "0.979" "1.089" "1.018" "0.923" "0.998" "904.4" "909.9" "828.2" "894.4" "923.1" "885.0" "984.6" "920.5" "834.6" "903.0" "" "" "" "" "" "" "" "" "" "" "904.4" "769.8" "523.7" "652.1" "756.3" "687.3" "759.0" "791.4" "651.4" "811.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "52.237" "17" "14" "20" "14" "907" "102.3" "7.14" "58.21" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "ISG15 antiviral mechanism" "4" "0" "0.968" "0.789" "0.983" "1.004" "0.837" "1.007" "1.022" "0.784" "0.884" "1156.2" "1119.8" "912.2" "1136.6" "1161.1" "967.2" "1164.4" "1181.8" "905.9" "1022.2" "" "" "" "" "" "" "" "" "" "" "1156.2" "947.4" "576.8" "828.7" "951.3" "751.1" "897.5" "1016.1" "707.1" "919.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8641441660686703988" "False" "High" "IsMasterProtein" "O94868" "F-BAR and double SH3 domains protein 2 OS=Homo sapiens OX=9606 GN=FCHSD2 PE=1 SV=3" "0.000" "False" "52.192" "19" "13" "18" "13" "740" "84.2" "5.77" "54.78" "13" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611, Pf14604" "9873" "ENSG00000137478" "FCHSD2" "B4DNI3; hsa:9873; O94868; Q7L8J9; Q8WVM2; Q96FV7; Q9UF77" "" "" "0" "0" "0.955" "0.864" "0.917" "0.959" "0.883" "0.951" "1.032" "0.833" "0.907" "1174.4" "1121.6" "1014.7" "1077.4" "1126.1" "1037.6" "1116.8" "1212.0" "978.8" "1065.4" "" "" "" "" "" "" "" "" "" "" "1174.4" "948.9" "641.6" "785.6" "922.6" "805.8" "860.9" "1042.1" "764.0" "957.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "52.099" "16" "5" "16" "5" "419" "49.5" "5.69" "54.40" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "Ethanol effects on histone modifications" "HATs acetylate histones" "2" "0" "1.057" "1.044" "1.063" "1.090" "1.054" "0.981" "1.030" "1.046" "1.030" "782.1" "826.7" "816.9" "831.3" "852.8" "824.5" "767.6" "805.8" "818.4" "805.7" "" "" "" "" "" "" "" "" "" "" "782.1" "699.4" "516.5" "606.1" "698.7" "640.3" "591.7" "692.9" "638.8" "724.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "52.067" "10" "15" "19" "15" "1555" "177.1" "5.63" "57.17" "15" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "IL-18 signaling pathway" "ER Quality Control Compartment (ERQC)" "2" "0" "1.045" "0.983" "1.061" "1.080" "1.038" "1.059" "1.030" "1.064" "1.043" "732.3" "765.5" "719.7" "776.7" "791.2" "759.9" "775.3" "754.7" "779.5" "763.7" "" "" "" "" "" "" "" "" "" "" "732.3" "647.6" "455.0" "566.3" "648.3" "590.1" "597.6" "648.9" "608.4" "686.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "52.053" "18" "14" "20" "14" "745" "86.9" "6.92" "61.01" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Regulation of expression of SLITs and ROBOs" "6" "0" "0.918" "1.040" "0.904" "0.946" "0.937" "0.928" "0.970" "0.910" "0.953" "884.7" "811.8" "920.1" "800.1" "837.4" "828.7" "820.7" "858.3" "805.4" "843.5" "" "" "" "" "" "" "" "" "" "" "884.7" "686.8" "581.8" "583.4" "686.1" "643.5" "632.6" "738.0" "628.7" "758.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "52.016" "7" "14" "19" "14" "2035" "208.6" "7.46" "56.17" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "Mitochondrial gene expression; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "6" "0" "1.039" "1.045" "1.082" "0.980" "1.052" "1.039" "0.942" "1.007" "1.022" "711.6" "739.3" "743.7" "770.1" "697.1" "748.3" "739.1" "670.4" "716.4" "727.3" "" "" "" "" "" "" "" "" "" "" "711.6" "625.5" "470.2" "561.5" "571.1" "581.2" "569.7" "576.4" "559.2" "653.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "51.978" "30" "13" "17" "13" "474" "53.3" "7.34" "56.75" "13" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "" "3" "0" "1.037" "1.052" "1.154" "1.066" "1.063" "1.118" "1.036" "0.999" "1.047" "499.2" "517.9" "525.1" "576.1" "532.2" "530.9" "558.3" "517.4" "498.8" "522.9" "" "" "" "" "" "" "" "" "" "" "499.2" "438.2" "332.0" "420.1" "436.0" "412.3" "430.4" "444.9" "389.3" "470.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "51.968" "20" "6" "22" "5" "332" "36.2" "8.21" "85.17" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "Pre-implantation embryo; mRNA processing" "" "2" "0" "1.170" "1.233" "1.020" "1.075" "1.195" "1.033" "0.932" "1.107" "1.122" "536.5" "627.8" "661.6" "547.2" "577.0" "641.2" "554.3" "500.1" "593.9" "601.8" "" "" "" "" "" "" "" "" "" "" "536.5" "531.1" "418.3" "399.0" "472.7" "497.9" "427.2" "430.0" "463.6" "541.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "51.945" "19" "12" "14" "11" "620" "69.9" "5.59" "48.74" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "" "6" "0" "1.053" "2.873" "1.137" "1.092" "2.867" "1.194" "1.031" "2.858" "1.676" "490.3" "516.1" "1408.8" "557.5" "535.3" "1405.7" "585.2" "505.5" "1401.5" "821.8" "" "" "" "" "" "" "" "" "" "" "490.3" "436.7" "890.8" "406.5" "438.5" "1091.6" "451.1" "434.6" "1094.0" "738.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "High" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.000" "False" "51.865" "16" "9" "16" "9" "593" "62.9" "4.91" "52.50" "9" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "HDAC6 interactions in the central nervous system" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "2" "0" "1.036" "0.909" "1.090" "1.020" "0.953" "1.039" "1.020" "0.845" "0.927" "585.9" "606.9" "532.5" "638.6" "597.6" "558.4" "608.5" "597.5" "494.9" "542.9" "" "" "" "" "" "" "" "" "" "" "585.9" "513.4" "336.7" "465.6" "489.6" "433.7" "469.0" "513.7" "386.3" "488.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "51.790" "10" "12" "14" "5" "1253" "145.1" "6.90" "46.42" "12" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "15" "0" "0.915" "0.772" "0.870" "0.894" "0.861" "0.873" "0.968" "0.765" "0.893" "397.0" "363.1" "306.3" "345.5" "355.1" "341.8" "346.6" "384.2" "303.7" "354.4" "" "" "" "" "" "" "" "" "" "" "397.0" "307.2" "193.7" "251.9" "290.9" "265.4" "267.2" "330.4" "237.1" "318.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "51.743" "19" "10" "19" "9" "523" "58.7" "6.67" "64.57" "10" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "1.108" "1.124" "1.051" "1.069" "1.161" "1.075" "1.017" "1.139" "1.045" "986.9" "1093.8" "1109.5" "1036.8" "1055.2" "1145.5" "1060.6" "1003.5" "1123.7" "1031.1" "" "" "" "" "" "" "" "" "" "" "986.9" "925.4" "701.6" "756.0" "864.5" "889.6" "817.6" "862.8" "877.2" "927.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "51.660" "10" "10" "17" "9" "1094" "118.2" "7.06" "60.38" "10" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "1.092" "1.002" "1.140" "1.075" "1.013" "1.155" "1.049" "1.027" "1.059" "1072.9" "1171.8" "1074.6" "1222.7" "1153.0" "1086.4" "1238.9" "1125.9" "1101.3" "1135.9" "" "" "" "" "" "" "" "" "" "" "1072.9" "991.3" "679.5" "891.5" "944.7" "843.7" "955.0" "968.1" "859.6" "1021.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119671646432562357" "False" "High" "IsMasterProtein" "P13929" "Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5" "0.000" "False" "51.646" "18" "5" "30" "2" "434" "47.0" "7.71" "123.42" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00113, Pf03952" "2027" "ENSG00000108515" "ENO3" "B4DUI6; B4DUM6; D3DTL2; E7ENK8; hsa:2027; P13929; Q96AE2" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "0" "1.055" "0.994" "1.099" "1.029" "1.012" "1.033" "0.933" "1.040" "1.057" "79.5" "83.9" "79.1" "87.4" "81.8" "80.5" "82.2" "74.2" "82.8" "84.1" "" "" "" "" "" "" "" "" "" "" "79.5" "71.0" "50.0" "63.8" "67.0" "62.5" "63.4" "63.8" "64.6" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "51.646" "8" "7" "12" "7" "1323" "142.8" "4.86" "51.15" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "2q37 copy number variation syndrome" "" "1" "0" "0.965" "0.823" "1.056" "1.121" "0.892" "1.081" "1.108" "0.843" "1.086" "404.1" "390.0" "332.4" "426.8" "452.8" "360.3" "436.9" "447.7" "340.7" "438.9" "" "" "" "" "" "" "" "" "" "" "404.1" "329.9" "210.2" "311.2" "371.0" "279.8" "336.8" "384.9" "265.9" "394.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6937145884149963662" "False" "High" "IsMasterProtein" "Q15306" "Interferon regulatory factor 4 OS=Homo sapiens OX=9606 GN=IRF4 PE=1 SV=1" "0.000" "False" "51.610" "21" "9" "23" "9" "451" "51.7" "6.86" "69.56" "9" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3662" "ENSG00000137265" "IRF4" "hsa:3662; Q15306; Q5VUI7; Q99660" "B cell receptor signaling pathway; Apoptosis; Vitamin D receptor pathway; Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets; Prion disease pathway; White fat cell differentiation; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Type II interferon signaling; T-cell receptor signaling pathway" "Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Interferon alpha/beta signaling; Nuclear events stimulated by ALK signaling in cancer" "15" "0" "1.001" "0.844" "0.954" "1.066" "0.869" "1.036" "1.008" "0.814" "0.972" "1490.7" "1491.5" "1258.5" "1422.4" "1589.2" "1296.1" "1543.8" "1502.8" "1213.3" "1449.0" "" "" "" "" "" "" "" "" "" "" "1490.7" "1261.9" "795.8" "1037.1" "1302.1" "1006.5" "1190.0" "1292.1" "947.0" "1302.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "51.581" "18" "9" "11" "9" "642" "72.9" "5.87" "41.33" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "1.067" "0.834" "0.964" "1.010" "0.863" "0.960" "1.013" "0.899" "0.914" "217.3" "231.9" "181.2" "209.5" "219.4" "187.6" "208.6" "220.1" "195.3" "198.6" "" "" "" "" "" "" "" "" "" "" "217.3" "196.2" "114.6" "152.7" "179.8" "145.7" "160.8" "189.3" "152.5" "178.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2954674220390740852" "False" "High" "IsMasterProtein" "P41218" "Myeloid cell nuclear differentiation antigen OS=Homo sapiens OX=9606 GN=MNDA PE=1 SV=1" "0.000" "False" "51.542" "21" "8" "16" "8" "407" "45.8" "9.76" "58.56" "8" "stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf02758, Pf02760" "4332" "ENSG00000163563" "MNDA" "P41218" "" "Neutrophil degranulation" "1" "0" "1.014" "1.302" "0.944" "1.020" "1.277" "0.960" "0.970" "1.300" "1.124" "696.4" "706.5" "906.5" "657.4" "710.7" "889.3" "668.4" "675.8" "905.3" "783.1" "" "" "" "" "" "" "" "" "" "" "696.4" "597.7" "573.2" "479.4" "582.3" "690.6" "515.2" "581.0" "706.7" "704.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815926444524445653" "False" "High" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "0.000" "False" "51.529" "4" "7" "18" "1" "1995" "227.7" "5.60" "65.43" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "6" "0" "1.285" "1.151" "1.426" "1.319" "1.310" "1.687" "1.498" "1.012" "1.229" "47.0" "60.4" "54.1" "67.0" "62.0" "61.6" "79.3" "70.4" "47.6" "57.8" "" "" "" "" "" "" "" "" "" "" "47.0" "51.1" "34.2" "48.9" "50.8" "47.8" "61.1" "60.6" "37.1" "51.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "51.509" "28" "8" "16" "6" "298" "33.9" "8.68" "59.20" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "47" "2" "0.910" "0.881" "0.897" "0.930" "0.903" "0.930" "0.979" "0.892" "0.991" "1013.0" "921.7" "892.6" "908.4" "942.5" "915.1" "941.9" "991.4" "903.5" "1004.4" "" "" "" "" "" "" "" "" "" "" "1013.0" "779.8" "564.4" "662.4" "772.2" "710.7" "726.1" "852.4" "705.2" "903.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "51.330" "32" "9" "21" "8" "271" "31.5" "6.87" "65.50" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "" "PI and PC transport between ER and Golgi membranes" "1" "0" "0.947" "1.052" "0.947" "0.938" "0.983" "0.940" "0.962" "1.022" "0.967" "1309.5" "1240.4" "1377.3" "1239.6" "1228.3" "1287.9" "1230.9" "1259.6" "1338.5" "1266.3" "" "" "" "" "" "" "" "" "" "" "1309.5" "1049.4" "870.9" "903.8" "1006.4" "1000.1" "948.8" "1083.0" "1044.8" "1138.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "51.288" "46" "7" "19" "7" "145" "16.1" "10.32" "55.26" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Complement system; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.056" "1.208" "1.135" "1.081" "1.303" "1.028" "1.129" "1.373" "1.096" "622.6" "657.8" "752.0" "706.6" "672.9" "811.2" "640.3" "703.0" "855.1" "682.5" "" "" "" "" "" "" "" "" "" "" "622.6" "556.5" "475.5" "515.2" "551.4" "630.0" "493.6" "604.5" "667.5" "613.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "51.116" "20" "10" "17" "10" "509" "54.1" "7.85" "53.45" "10" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "19" "0" "1.002" "1.073" "0.973" "1.032" "1.047" "0.950" "0.972" "1.011" "1.075" "1223.8" "1226.8" "1313.8" "1190.7" "1263.4" "1280.8" "1163.1" "1189.5" "1236.8" "1316.1" "" "" "" "" "" "" "" "" "" "" "1223.8" "1037.9" "830.7" "868.2" "1035.1" "994.7" "896.5" "1022.7" "965.4" "1183.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "51.077" "33" "7" "23" "7" "243" "27.3" "5.08" "84.70" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "1.063" "1.541" "0.990" "1.037" "1.293" "0.931" "0.947" "1.364" "1.109" "1471.3" "1564.4" "2267.2" "1456.3" "1525.3" "1901.9" "1369.1" "1393.3" "2006.6" "1631.3" "" "" "" "" "" "" "" "" "" "" "1471.3" "1323.5" "1433.6" "1061.9" "1249.7" "1477.0" "1055.4" "1197.9" "1566.2" "1466.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "51.074" "21" "10" "17" "5" "616" "64.4" "7.25" "57.79" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.169" "0.933" "1.221" "1.222" "1.128" "1.294" "1.001" "0.918" "1.089" "104.8" "122.5" "97.8" "127.9" "128.1" "118.3" "135.6" "104.8" "96.2" "114.2" "" "" "" "" "" "" "" "" "" "" "104.8" "103.6" "61.8" "93.3" "104.9" "91.8" "104.5" "90.1" "75.1" "102.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "51.026" "18" "11" "14" "11" "684" "75.4" "6.61" "50.28" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.059" "0.999" "0.980" "0.972" "1.018" "0.961" "0.946" "0.994" "1.013" "651.7" "690.4" "651.2" "638.8" "633.2" "663.2" "626.2" "616.7" "647.6" "660.1" "" "" "" "" "" "" "" "" "" "" "651.7" "584.1" "411.7" "465.8" "518.8" "515.0" "482.7" "530.3" "505.5" "593.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "50.970" "28" "12" "23" "4" "427" "49.1" "5.68" "63.66" "12" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "7" "0.987" "0.864" "0.957" "0.961" "0.869" "0.905" "0.958" "0.821" "0.978" "1400.3" "1381.9" "1209.7" "1340.2" "1345.5" "1217.0" "1266.7" "1341.1" "1149.7" "1369.4" "" "" "" "" "" "" "" "" "" "" "1400.3" "1169.1" "764.9" "977.2" "1102.3" "945.1" "976.4" "1153.1" "897.4" "1231.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "50.855" "24" "9" "13" "9" "389" "44.1" "7.49" "46.88" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "65" "0" "0.998" "0.916" "0.986" "0.975" "0.909" "0.999" "0.981" "0.909" "1.005" "694.7" "693.2" "636.6" "684.9" "677.4" "631.8" "694.1" "681.7" "631.7" "698.0" "" "" "" "" "" "" "" "" "" "" "694.7" "586.4" "402.5" "499.4" "555.0" "490.6" "535.1" "586.1" "493.1" "627.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892947756111346869" "False" "High" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.000" "False" "50.819" "6" "16" "17" "16" "2549" "288.7" "7.17" "52.64" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; HSF1-dependent transactivation" "92" "0" "1.156" "0.975" "1.015" "1.105" "1.001" "1.080" "1.061" "1.025" "1.107" "479.5" "554.4" "467.5" "486.8" "529.7" "479.9" "518.1" "508.8" "491.5" "531.0" "" "" "" "" "" "" "" "" "" "" "479.5" "469.0" "295.6" "354.9" "434.0" "372.7" "399.4" "437.5" "383.7" "477.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "50.795" "19" "9" "18" "9" "474" "51.3" "9.41" "55.36" "9" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "12" "0" "1.001" "0.978" "0.915" "0.981" "0.926" "0.896" "0.956" "0.893" "0.944" "801.0" "802.0" "783.2" "733.2" "786.0" "742.0" "717.7" "766.1" "715.1" "756.1" "" "" "" "" "" "" "" "" "" "" "801.0" "678.5" "495.2" "534.6" "644.0" "576.2" "553.2" "658.6" "558.2" "679.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1831156275587946455" "False" "High" "IsMasterProtein" "Q7Z401" "C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2" "0.000" "False" "50.772" "8" "13" "16" "12" "1863" "209.1" "7.31" "47.84" "13" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf02141, Pf03455, Pf03456" "10260" "ENSG00000174485" "DENND4A" "E7EPL3; hsa:10260; Q14655; Q7Z401; Q86T77; Q8IVX2; Q8NB93" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.005" "0.851" "1.133" "0.988" "0.869" "1.040" "1.073" "0.898" "0.932" "517.0" "519.3" "439.9" "585.6" "510.7" "449.1" "537.9" "554.7" "464.4" "481.9" "" "" "" "" "" "" "" "" "" "" "517.0" "439.4" "278.1" "427.0" "418.4" "348.7" "414.6" "476.9" "362.5" "433.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "50.731" "15" "11" "18" "10" "815" "92.5" "5.31" "55.89" "11" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "1" "1.029" "0.992" "1.010" "0.996" "1.002" "1.016" "1.030" "0.990" "0.989" "759.0" "781.2" "753.1" "766.3" "755.6" "760.8" "770.9" "781.8" "751.6" "750.3" "" "" "" "" "" "" "" "" "" "" "759.0" "660.9" "476.2" "558.8" "619.1" "590.9" "594.2" "672.2" "586.7" "674.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "50.497" "22" "8" "17" "7" "406" "46.9" "5.26" "61.19" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "" "Neutrophil degranulation" "1" "0" "0.992" "0.973" "1.116" "1.006" "1.055" "1.034" "1.034" "1.041" "1.108" "515.3" "511.4" "501.4" "575.2" "518.3" "543.5" "532.9" "532.7" "536.7" "570.8" "" "" "" "" "" "" "" "" "" "" "515.3" "432.6" "317.0" "419.4" "424.6" "422.1" "410.8" "458.0" "418.9" "513.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "50.460" "27" "7" "24" "5" "297" "34.1" "8.40" "74.28" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "50" "0" "1.041" "0.766" "1.043" "1.112" "0.865" "0.979" "0.984" "0.767" "0.920" "728.8" "758.6" "558.0" "760.5" "810.4" "630.5" "713.3" "716.9" "559.4" "670.6" "" "" "" "" "" "" "" "" "" "" "728.8" "641.8" "352.8" "554.5" "664.0" "489.6" "549.8" "616.3" "436.6" "602.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "50.367" "17" "10" "13" "10" "669" "69.4" "9.67" "46.36" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "Ciliary landscape" "RUNX2 regulates bone development" "2" "0" "1.035" "0.939" "1.006" "1.031" "1.017" "1.046" "1.030" "0.993" "1.069" "680.0" "704.0" "638.3" "684.1" "701.2" "691.5" "711.2" "700.6" "675.1" "726.8" "" "" "" "" "" "" "" "" "" "" "680.0" "595.6" "403.6" "498.8" "574.5" "537.0" "548.2" "602.4" "526.9" "653.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7100532501288988865" "False" "High" "IsMasterProtein" "P55795" "Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1" "0.000" "False" "50.357" "17" "6" "19" "1" "449" "49.2" "6.30" "55.30" "6" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00076, Pf08080" "3188" "ENSG00000126945" "HNRNPH2" "A1L400; P55795; Q9HHA7" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "50.265" "7" "11" "13" "11" "1636" "178.9" "6.92" "39.03" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "" "Interleukin-37 signaling" "1" "0" "0.955" "0.944" "1.056" "0.960" "0.953" "1.047" "1.059" "0.920" "0.991" "439.2" "419.3" "414.6" "463.6" "421.6" "418.5" "460.0" "465.0" "404.1" "435.0" "" "" "" "" "" "" "" "" "" "" "439.2" "354.8" "262.1" "338.1" "345.4" "325.0" "354.6" "399.8" "315.5" "391.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "50.252" "13" "10" "15" "10" "796" "91.6" "5.49" "51.88" "10" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.085" "1.028" "1.084" "1.068" "0.988" "1.039" "1.080" "1.062" "1.078" "608.3" "659.8" "625.4" "659.3" "649.5" "600.9" "631.8" "657.0" "645.7" "655.9" "" "" "" "" "" "" "" "" "" "" "608.3" "558.2" "395.5" "480.7" "532.2" "466.6" "487.0" "564.9" "504.0" "589.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "50.225" "23" "7" "15" "7" "397" "41.3" "6.92" "57.77" "7" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "6" "0" "0.958" "0.981" "1.062" "0.897" "1.015" "0.932" "0.975" "1.077" "1.004" "564.7" "541.2" "553.9" "599.8" "506.4" "572.9" "526.1" "550.8" "608.3" "567.1" "" "" "" "" "" "" "" "" "" "" "564.7" "457.8" "350.2" "437.4" "414.9" "444.9" "405.6" "473.5" "474.8" "509.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "50.222" "21" "9" "15" "3" "491" "56.3" "5.24" "49.28" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "Signaling by Hippo" "9" "0" "0.987" "0.848" "0.896" "1.010" "0.677" "0.791" "0.872" "0.594" "0.690" "85.3" "84.2" "72.3" "76.4" "86.1" "57.7" "67.5" "74.3" "50.6" "58.8" "" "" "" "" "" "" "" "" "" "" "85.3" "71.2" "45.7" "55.7" "70.6" "44.8" "52.0" "63.9" "39.5" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "50.219" "34" "13" "20" "12" "370" "40.7" "7.21" "63.21" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "ESR-mediated signaling" "4" "0" "0.959" "0.856" "1.047" "0.985" "0.922" "1.011" "1.015" "0.879" "1.004" "695.7" "667.3" "595.6" "728.7" "685.0" "641.7" "703.3" "706.2" "611.5" "698.4" "" "" "" "" "" "" "" "" "" "" "695.7" "564.6" "376.6" "531.3" "561.2" "498.3" "542.1" "607.2" "477.3" "627.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.000" "False" "50.170" "17" "7" "11" "5" "515" "58.2" "9.25" "45.43" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "6" "2" "1.025" "0.999" "1.066" "0.993" "0.943" "1.055" "1.021" "0.940" "1.006" "447.7" "458.7" "447.4" "477.4" "444.5" "422.1" "472.3" "457.1" "420.7" "450.4" "" "" "" "" "" "" "" "" "" "" "447.7" "388.1" "282.9" "348.1" "364.2" "327.8" "364.1" "393.0" "328.4" "404.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "50.168" "17" "10" "18" "9" "612" "68.2" "6.73" "56.38" "10" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Clear cell renal cell carcinoma pathways; Glucuronidation" "Neutrophil degranulation; Pentose phosphate pathway" "4" "0" "1.045" "1.014" "1.020" "1.023" "1.104" "0.963" "1.013" "1.078" "1.027" "885.4" "925.2" "897.8" "903.5" "905.4" "977.4" "853.0" "896.8" "954.5" "909.4" "" "" "" "" "" "" "" "" "" "" "885.4" "782.7" "567.7" "658.8" "741.8" "759.0" "657.5" "771.0" "745.0" "817.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "50.149" "20" "8" "22" "7" "420" "46.4" "9.57" "73.63" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "1.046" "1.198" "0.924" "1.001" "1.085" "0.914" "0.802" "1.173" "1.154" "1031.8" "1078.8" "1235.7" "953.2" "1032.6" "1119.9" "942.8" "827.7" "1210.0" "1191.0" "" "" "" "" "" "" "" "" "" "" "1031.8" "912.7" "781.3" "695.0" "846.0" "869.7" "726.7" "711.6" "944.5" "1070.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "50.148" "21" "8" "20" "3" "425" "47.6" "4.89" "67.00" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "Potential therapeutics for SARS; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "28" "0" "1.002" "1.095" "0.961" "0.924" "0.975" "1.055" "1.026" "0.931" "1.000" "477.8" "478.9" "523.3" "459.0" "441.4" "465.8" "503.9" "490.4" "444.7" "477.9" "" "" "" "" "" "" "" "" "" "" "477.8" "405.1" "330.9" "334.6" "361.7" "361.7" "388.4" "421.6" "347.1" "429.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "50.141" "50" "9" "23" "9" "183" "20.9" "7.69" "70.48" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; TGF-beta receptor signaling activates SMADs" "5" "0" "0.960" "1.056" "0.948" "0.972" "1.024" "0.884" "0.939" "0.999" "1.026" "1258.0" "1207.3" "1328.0" "1192.6" "1222.8" "1288.2" "1111.7" "1181.0" "1257.2" "1290.8" "" "" "" "" "" "" "" "" "" "" "1258.0" "1021.4" "839.7" "869.6" "1001.9" "1000.4" "857.0" "1015.4" "981.4" "1160.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "50.113" "12" "10" "21" "10" "932" "97.3" "8.63" "60.25" "10" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.055" "1.038" "1.071" "1.007" "1.053" "1.010" "1.013" "0.998" "1.020" "1054.0" "1112.3" "1094.3" "1128.5" "1061.2" "1109.7" "1064.2" "1067.9" "1051.7" "1075.4" "" "" "" "" "" "" "" "" "" "" "1054.0" "941.0" "691.9" "822.8" "869.5" "861.8" "820.3" "918.2" "820.9" "966.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "50.111" "16" "8" "17" "8" "522" "56.2" "8.50" "53.88" "8" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "" "11" "0" "0.991" "0.992" "1.000" "0.935" "1.006" "0.982" "1.013" "1.026" "1.012" "795.3" "787.8" "789.0" "795.5" "743.3" "800.0" "781.0" "805.4" "815.9" "805.0" "" "" "" "" "" "" "" "" "" "" "795.3" "666.5" "498.9" "580.1" "609.0" "621.3" "602.0" "692.5" "636.9" "723.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "50.106" "47" "7" "13" "7" "193" "20.6" "8.57" "51.56" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "MTF1 activates gene expression" "3" "0" "0.918" "1.026" "0.893" "0.933" "1.041" "0.960" "0.942" "0.990" "0.961" "1286.5" "1181.5" "1320.3" "1149.4" "1200.6" "1339.7" "1234.4" "1211.9" "1274.2" "1236.8" "" "" "" "" "" "" "" "" "" "" "1286.5" "999.6" "834.8" "838.1" "983.7" "1040.4" "951.5" "1042.0" "994.6" "1112.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "50.096" "2" "3" "12" "3" "2078" "205.3" "9.58" "49.11" "3" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "0.978" "0.931" "1.016" "0.905" "0.892" "0.914" "0.945" "0.921" "0.985" "997.5" "976.0" "928.3" "1013.6" "902.8" "889.5" "911.8" "942.5" "918.5" "983.0" "" "" "" "" "" "" "" "" "" "" "997.5" "825.8" "586.9" "739.0" "739.7" "690.8" "702.9" "810.4" "716.9" "883.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "50.059" "15" "7" "15" "7" "638" "71.4" "5.20" "55.42" "7" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "23" "0" "0.983" "0.978" "1.013" "0.993" "0.947" "0.993" "1.035" "1.034" "0.996" "613.0" "602.4" "599.5" "621.3" "608.5" "580.7" "608.6" "634.7" "633.9" "610.4" "" "" "" "" "" "" "" "" "" "" "613.0" "509.6" "379.1" "453.0" "498.5" "450.9" "469.1" "545.7" "494.8" "548.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "49.944" "19" "8" "14" "8" "534" "60.2" "5.40" "52.36" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "Neddylation" "4" "0" "1.035" "1.081" "1.001" "1.052" "1.081" "1.022" "1.087" "1.047" "1.079" "796.2" "823.7" "860.4" "797.0" "837.8" "860.6" "814.1" "865.1" "834.0" "858.7" "" "" "" "" "" "" "" "" "" "" "796.2" "696.9" "544.0" "581.2" "686.4" "668.3" "627.5" "743.8" "651.0" "772.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2779381262289932464" "False" "High" "IsMasterProtein" "P17655" "Calpain-2 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN2 PE=1 SV=6" "0.000" "False" "49.810" "17" "10" "13" "10" "700" "79.9" "4.98" "52.89" "10" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00648, Pf01067, Pf13833" "824" "ENSG00000162909" "CAPN2" "A6NDG7; B7ZA96; E7ES58; hsa:824; P17655; Q16738; Q6PJT3; Q8WU26; Q9HBB1" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Focal adhesion; VEGFA-VEGFR2 signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "8" "0" "0.972" "1.115" "1.011" "0.958" "1.023" "0.983" "1.021" "1.017" "1.012" "1260.5" "1225.1" "1405.0" "1274.1" "1207.5" "1289.7" "1239.0" "1286.6" "1282.3" "1275.3" "" "" "" "" "" "" "" "" "" "" "1260.5" "1036.5" "888.4" "929.0" "989.3" "1001.5" "955.1" "1106.2" "1000.9" "1146.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "49.808" "24" "11" "19" "11" "528" "60.5" "7.52" "57.88" "11" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "0.982" "0.916" "1.035" "1.005" "0.959" "1.107" "1.005" "0.910" "0.995" "813.6" "798.8" "745.6" "842.2" "817.9" "780.0" "901.0" "817.5" "740.6" "809.5" "" "" "" "" "" "" "" "" "" "" "813.6" "675.8" "471.5" "614.1" "670.1" "605.8" "694.5" "702.9" "578.1" "727.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "49.742" "12" "10" "18" "10" "895" "100.2" "5.67" "60.21" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.081" "1.083" "0.965" "1.023" "1.014" "1.021" "1.007" "1.064" "1.015" "1263.6" "1366.0" "1367.8" "1219.7" "1293.2" "1281.7" "1289.7" "1272.6" "1344.5" "1282.2" "" "" "" "" "" "" "" "" "" "" "1263.6" "1155.6" "864.9" "889.4" "1059.5" "995.3" "994.2" "1094.2" "1049.5" "1152.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "49.712" "25" "12" "21" "11" "419" "48.0" "5.92" "66.52" "12" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.984" "0.969" "0.983" "0.933" "0.972" "0.921" "0.970" "0.945" "1.032" "935.4" "920.7" "906.2" "919.1" "872.8" "909.4" "861.5" "907.7" "884.1" "965.4" "" "" "" "" "" "" "" "" "" "" "935.4" "778.9" "573.0" "670.2" "715.1" "706.2" "664.1" "780.4" "690.1" "868.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755296670490160775" "False" "High" "IsMasterProtein" "Q96SB3" "Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3" "0.000" "False" "49.691" "11" "9" "15" "9" "817" "89.3" "4.97" "47.55" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00595, Pf17817" "84687" "ENSG00000108819" "PPP1R9B" "D3DTX6; hsa:84687; Q8TCR9; Q96SB3" "" "" "0" "0" "1.012" "1.360" "1.089" "1.153" "1.418" "1.170" "1.080" "1.397" "1.204" "279.5" "282.8" "380.3" "304.3" "322.4" "396.4" "327.0" "301.8" "390.5" "336.6" "" "" "" "" "" "" "" "" "" "" "279.5" "239.3" "240.5" "221.9" "264.2" "307.9" "252.0" "259.5" "304.8" "302.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "49.666" "26" "9" "16" "9" "376" "42.4" "5.86" "46.38" "9" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "0.961" "1.146" "1.091" "0.908" "1.114" "0.944" "0.884" "1.084" "1.057" "397.5" "382.0" "455.6" "433.7" "360.9" "442.7" "375.3" "351.6" "430.8" "420.3" "" "" "" "" "" "" "" "" "" "" "397.5" "323.2" "288.1" "316.2" "295.7" "343.8" "289.3" "302.3" "336.3" "377.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "49.609" "53" "6" "28" "6" "135" "15.2" "7.01" "104.10" "6" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "PPAR signaling pathway; Fatty acid transporters" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "5" "0" "0.996" "1.111" "0.992" "0.990" "0.995" "0.954" "0.974" "1.059" "1.057" "2709.2" "2698.3" "3010.6" "2688.9" "2683.4" "2694.8" "2583.8" "2637.7" "2868.2" "2864.5" "" "" "" "" "" "" "" "" "" "" "2709.2" "2282.8" "1903.6" "1960.6" "2198.5" "2092.8" "1991.7" "2267.9" "2238.8" "2575.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "49.605" "13" "7" "42" "2" "641" "70.3" "6.02" "138.83" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "8" "0" "0.882" "0.868" "0.918" "0.836" "0.868" "0.875" "0.988" "0.940" "1.119" "186.1" "164.1" "161.5" "170.9" "155.5" "161.5" "162.8" "183.8" "174.9" "208.3" "" "" "" "" "" "" "" "" "" "" "186.1" "138.8" "102.1" "124.6" "127.4" "125.4" "125.5" "158.0" "136.5" "187.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "49.572" "5" "11" "12" "11" "2012" "227.8" "6.19" "41.95" "11" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "29" "0" "1.068" "0.795" "1.045" "1.009" "0.834" "1.013" "1.013" "0.832" "0.995" "687.5" "733.9" "546.5" "718.4" "693.9" "573.1" "696.7" "696.6" "571.9" "683.7" "" "" "" "" "" "" "" "" "" "" "687.5" "620.9" "345.5" "523.8" "568.5" "445.0" "537.0" "598.9" "446.4" "614.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "49.570" "22" "14" "23" "12" "572" "61.6" "8.38" "67.81" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.060" "0.973" "1.023" "1.003" "0.952" "0.979" "0.949" "0.943" "0.918" "1032.9" "1094.3" "1005.2" "1056.4" "1035.5" "982.8" "1011.5" "979.8" "974.1" "948.5" "" "" "" "" "" "" "" "" "" "" "1032.9" "925.8" "635.6" "770.3" "848.4" "763.2" "779.7" "842.4" "760.3" "852.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "49.554" "14" "6" "8" "6" "623" "65.7" "6.07" "35.22" "6" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "1.116" "0.910" "1.081" "1.070" "0.998" "1.019" "1.159" "0.921" "1.017" "261.7" "292.1" "238.3" "282.8" "280.1" "261.2" "266.7" "303.3" "241.0" "266.2" "" "" "" "" "" "" "" "" "" "" "261.7" "247.2" "150.7" "206.2" "229.5" "202.8" "205.6" "260.8" "188.1" "239.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "49.496" "31" "8" "24" "8" "272" "30.6" "6.00" "69.72" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "VEGFA-VEGFR2 signaling" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "9" "0" "1.037" "1.177" "1.047" "1.010" "1.080" "1.003" "1.053" "1.101" "1.045" "1337.9" "1387.1" "1574.5" "1401.1" "1351.4" "1444.3" "1341.7" "1408.5" "1473.7" "1398.8" "" "" "" "" "" "" "" "" "" "" "1337.9" "1173.5" "995.5" "1021.6" "1107.2" "1121.6" "1034.3" "1211.1" "1150.3" "1257.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "49.452" "39" "10" "29" "9" "289" "32.6" "5.86" "82.86" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "1" "0.993" "1.099" "0.960" "0.952" "1.108" "1.022" "0.933" "1.055" "1.092" "872.5" "866.8" "959.0" "837.2" "830.7" "967.0" "891.4" "813.7" "920.4" "953.2" "" "" "" "" "" "" "" "" "" "" "872.5" "733.3" "606.4" "610.5" "680.6" "750.9" "687.2" "699.7" "718.4" "857.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "49.400" "23" "9" "16" "9" "426" "48.6" "5.31" "62.48" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "VEGFA-VEGFR2 signaling" "Protein hydroxylation" "2" "0" "1.031" "0.943" "1.072" "1.011" "0.873" "1.051" "1.031" "0.867" "1.013" "815.2" "840.9" "769.0" "874.0" "824.0" "711.4" "857.1" "840.1" "706.7" "826.2" "" "" "" "" "" "" "" "" "" "" "815.2" "711.4" "486.3" "637.3" "675.1" "552.4" "660.6" "722.3" "551.6" "742.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "49.338" "13" "8" "16" "8" "759" "85.2" "6.84" "49.82" "8" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "0" "1.004" "0.996" "1.069" "1.023" "1.042" "1.029" "0.993" "0.995" "0.958" "698.6" "701.6" "695.9" "746.5" "714.8" "728.0" "718.8" "693.8" "694.8" "669.2" "" "" "" "" "" "" "" "" "" "" "698.6" "593.5" "440.1" "544.3" "585.6" "565.3" "554.1" "596.5" "542.3" "601.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "49.267" "24" "10" "15" "10" "491" "55.5" "6.74" "48.43" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "5" "0" "1.101" "1.087" "1.023" "0.991" "1.004" "0.965" "1.002" "1.084" "1.079" "894.7" "985.1" "972.9" "915.8" "887.0" "898.6" "863.4" "896.4" "969.5" "965.6" "" "" "" "" "" "" "" "" "" "" "894.7" "833.4" "615.2" "667.7" "726.7" "697.9" "665.5" "770.7" "756.8" "868.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "49.232" "12" "12" "22" "12" "1037" "117.3" "6.92" "67.82" "12" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "" "Mitochondrial protein import" "1" "0" "1.003" "0.959" "0.971" "1.026" "1.013" "0.984" "0.997" "1.115" "1.005" "1023.9" "1027.2" "981.8" "994.7" "1050.1" "1037.4" "1007.5" "1020.8" "1141.8" "1029.5" "" "" "" "" "" "" "" "" "" "" "1023.9" "869.0" "620.8" "725.3" "860.4" "805.6" "776.6" "877.7" "891.3" "925.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "49.164" "33" "8" "14" "8" "263" "28.5" "6.92" "46.81" "8" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.995" "1.001" "0.957" "0.941" "1.042" "0.893" "0.975" "1.043" "1.089" "660.7" "657.4" "661.7" "632.3" "621.9" "688.4" "589.7" "644.4" "688.9" "719.6" "" "" "" "" "" "" "" "" "" "" "660.7" "556.2" "418.4" "461.0" "509.6" "534.6" "454.6" "554.1" "537.7" "646.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "49.133" "31" "4" "12" "4" "237" "26.2" "4.11" "48.47" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "" "snRNP Assembly" "1" "0" "1.003" "1.043" "1.056" "0.993" "1.047" "0.993" "0.996" "1.070" "1.108" "382.2" "383.2" "398.8" "403.7" "379.7" "400.1" "379.4" "380.6" "409.0" "423.5" "" "" "" "" "" "" "" "" "" "" "382.2" "324.2" "252.2" "294.3" "311.0" "310.7" "292.5" "327.2" "319.2" "380.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "49.124" "19" "9" "16" "9" "463" "50.3" "7.42" "54.68" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "" "Citric acid cycle (TCA cycle)" "1" "0" "1.013" "1.026" "0.973" "0.981" "0.995" "0.951" "0.964" "0.962" "0.953" "882.2" "893.3" "905.5" "858.0" "865.5" "877.7" "839.3" "850.7" "848.8" "841.1" "" "" "" "" "" "" "" "" "" "" "882.2" "755.8" "572.5" "625.6" "709.1" "681.6" "647.0" "731.4" "662.5" "756.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "48.999" "17" "12" "19" "7" "689" "79.5" "7.28" "62.93" "12" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "Cargo recognition for clathrin-mediated endocytosis; G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Calmodulin induced events" "9" "3" "1.069" "0.915" "1.086" "1.040" "0.925" "1.051" "1.068" "0.917" "1.026" "1088.9" "1163.9" "996.3" "1182.6" "1132.7" "1007.2" "1144.2" "1162.5" "998.4" "1116.7" "" "" "" "" "" "" "" "" "" "" "1088.9" "984.7" "630.0" "862.3" "928.0" "782.1" "882.0" "999.5" "779.3" "1003.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "48.910" "23" "12" "23" "12" "522" "56.0" "8.78" "75.54" "12" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.057" "1.036" "0.954" "0.967" "0.940" "0.859" "0.913" "0.974" "1.031" "1796.5" "1899.3" "1862.0" "1713.0" "1737.0" "1689.0" "1543.6" "1640.4" "1750.6" "1853.0" "" "" "" "" "" "" "" "" "" "" "1796.5" "1606.9" "1177.4" "1249.0" "1423.2" "1311.6" "1189.9" "1410.4" "1366.5" "1665.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "48.889" "16" "10" "21" "10" "599" "67.3" "8.34" "63.20" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "1.012" "0.994" "1.026" "1.005" "1.091" "0.987" "1.057" "1.025" "1.045" "998.9" "1010.5" "993.0" "1025.4" "1004.0" "1090.2" "985.8" "1056.2" "1023.8" "1044.2" "" "" "" "" "" "" "" "" "" "" "998.9" "854.9" "627.9" "747.7" "822.6" "846.6" "759.9" "908.1" "799.1" "938.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "48.855" "10" "13" "16" "6" "1278" "148.3" "7.31" "48.27" "13" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "Fragile X syndrome; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "7" "5" "1.010" "0.876" "1.062" "1.026" "0.897" "1.074" "1.023" "0.921" "0.959" "973.8" "983.7" "852.7" "1034.4" "999.0" "873.1" "1046.0" "996.3" "896.5" "934.3" "" "" "" "" "" "" "" "" "" "" "973.8" "832.3" "539.2" "754.2" "818.5" "678.0" "806.3" "856.6" "699.8" "840.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "48.832" "24" "10" "20" "9" "414" "46.6" "7.01" "59.36" "10" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "8" "0" "0.994" "1.040" "0.954" "0.928" "1.043" "0.969" "0.989" "1.064" "1.009" "1001.3" "994.8" "1041.6" "955.6" "929.4" "1043.9" "970.4" "990.1" "1065.8" "1010.7" "" "" "" "" "" "" "" "" "" "" "1001.3" "841.6" "658.6" "696.7" "761.5" "810.7" "748.0" "851.3" "831.9" "908.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "48.804" "13" "11" "16" "11" "783" "85.9" "7.77" "55.31" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Pyrimidine metabolism; miRNA degrading enzymes" "Mitochondrial RNA degradation" "3" "0" "1.036" "1.103" "0.994" "1.080" "1.100" "1.028" "1.047" "1.062" "1.049" "890.1" "922.2" "981.9" "884.9" "961.7" "979.5" "915.1" "932.3" "945.7" "934.1" "" "" "" "" "" "" "" "" "" "" "890.1" "780.2" "620.8" "645.2" "788.0" "760.7" "705.4" "801.6" "738.2" "839.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "48.742" "10" "8" "10" "8" "979" "107.1" "5.74" "42.79" "8" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "Ciliopathies" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "4" "0" "1.055" "1.032" "1.030" "1.125" "1.087" "1.065" "1.090" "1.050" "1.101" "670.2" "707.1" "691.7" "690.2" "753.8" "728.6" "714.1" "730.3" "703.7" "737.8" "" "" "" "" "" "" "" "" "" "" "670.2" "598.2" "437.4" "503.2" "617.6" "565.8" "550.5" "627.9" "549.3" "663.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "48.708" "16" "8" "15" "8" "575" "58.9" "7.49" "48.37" "8" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "5" "0" "1.060" "1.014" "1.086" "1.090" "1.053" "1.014" "0.969" "1.046" "1.019" "859.0" "910.9" "871.2" "932.9" "936.0" "904.4" "870.9" "832.4" "898.7" "875.2" "" "" "" "" "" "" "" "" "" "" "859.0" "770.6" "550.9" "680.2" "766.9" "702.3" "671.3" "715.7" "701.5" "786.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "48.701" "18" "8" "26" "6" "409" "43.1" "4.84" "76.18" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "8" "2" "0.971" "1.027" "1.064" "1.009" "1.063" "1.077" "0.975" "1.067" "1.000" "2326.1" "2257.6" "2389.4" "2475.2" "2347.6" "2471.5" "2506.0" "2267.9" "2482.6" "2327.0" "" "" "" "" "" "" "" "" "" "" "2326.1" "1910.0" "1510.8" "1804.8" "1923.4" "1919.3" "1931.7" "1950.0" "1937.8" "2092.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "48.572" "31" "12" "16" "12" "427" "47.4" "8.41" "44.39" "12" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "1.005" "0.927" "1.004" "0.989" "0.889" "1.011" "1.004" "0.938" "1.010" "924.8" "929.5" "857.5" "928.4" "914.3" "822.2" "934.8" "928.4" "867.1" "933.8" "" "" "" "" "" "" "" "" "" "" "924.8" "786.4" "542.2" "677.0" "749.1" "638.5" "720.6" "798.3" "676.8" "839.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "48.466" "41" "9" "15" "9" "211" "23.8" "6.70" "53.81" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Pleural mesothelioma" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.003" "0.960" "1.039" "1.005" "0.961" "1.075" "1.071" "0.919" "0.965" "1136.6" "1140.2" "1090.7" "1180.8" "1141.8" "1092.4" "1222.0" "1217.5" "1044.9" "1096.7" "" "" "" "" "" "" "" "" "" "" "1136.6" "964.6" "689.7" "861.0" "935.5" "848.3" "941.9" "1046.8" "815.6" "986.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "48.439" "13" "15" "17" "14" "1096" "123.4" "8.82" "51.85" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "4" "0" "1.032" "1.484" "1.016" "1.048" "1.529" "1.058" "1.130" "1.522" "1.157" "529.1" "546.1" "785.0" "537.4" "554.4" "808.9" "559.9" "597.8" "805.1" "612.3" "" "" "" "" "" "" "" "" "" "" "529.1" "462.0" "496.4" "391.8" "454.3" "628.2" "431.6" "513.9" "628.4" "550.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "48.316" "21" "6" "14" "6" "339" "39.2" "5.38" "48.14" "6" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.018" "0.946" "1.108" "1.038" "0.935" "1.071" "1.106" "0.954" "0.962" "480.0" "488.6" "454.0" "532.0" "498.2" "449.0" "514.0" "531.0" "457.7" "461.9" "" "" "" "" "" "" "" "" "" "" "480.0" "413.4" "287.0" "387.9" "408.2" "348.7" "396.2" "456.5" "357.2" "415.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "48.202" "14" "8" "10" "6" "621" "69.7" "6.15" "38.91" "8" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Bile acids synthesis and enterohepatic circulation" "Signaling by BRAF and RAF1 fusions" "2" "1" "1.196" "1.089" "1.182" "1.102" "1.143" "1.181" "1.101" "1.130" "1.028" "279.6" "334.4" "304.5" "330.5" "308.2" "319.7" "330.1" "308.0" "316.0" "287.4" "" "" "" "" "" "" "" "" "" "" "279.6" "282.9" "192.5" "241.0" "252.5" "248.3" "254.4" "264.8" "246.6" "258.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "48.123" "5" "8" "11" "7" "2157" "228.7" "9.45" "36.96" "8" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "1.092" "1.091" "1.033" "1.076" "1.173" "1.065" "1.076" "1.139" "1.010" "615.7" "672.2" "671.5" "635.9" "662.4" "722.0" "655.8" "662.8" "701.4" "621.8" "" "" "" "" "" "" "" "" "" "" "615.7" "568.7" "424.6" "463.7" "542.7" "560.7" "505.5" "569.8" "547.5" "559.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "48.034" "18" "8" "28" "3" "425" "47.8" "5.05" "88.28" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "Transcriptional Regulation by E2F6; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "20" "5" "0.951" "1.001" "1.060" "0.926" "1.028" "1.041" "0.995" "0.976" "1.046" "2240.9" "2131.3" "2243.0" "2376.1" "2074.6" "2303.8" "2332.7" "2230.1" "2186.1" "2344.6" "" "" "" "" "" "" "" "" "" "" "2240.9" "1803.1" "1418.3" "1732.5" "1699.7" "1789.1" "1798.1" "1917.5" "1706.4" "2107.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "48.015" "5" "11" "15" "11" "2752" "299.4" "12.06" "52.43" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "" "mRNA Splicing - Major Pathway" "1" "0" "0.987" "1.301" "1.083" "1.072" "1.270" "1.082" "1.113" "1.247" "1.081" "569.4" "562.0" "741.1" "616.6" "610.7" "723.2" "616.2" "633.9" "710.3" "615.4" "" "" "" "" "" "" "" "" "" "" "569.4" "475.5" "468.6" "449.6" "500.3" "561.6" "475.0" "545.0" "554.4" "553.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "48.007" "68" "8" "47" "8" "102" "10.9" "8.92" "139.37" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "" "RHOG GTPase cycle" "1" "0" "0.977" "1.076" "0.919" "0.956" "1.014" "1.009" "0.886" "1.020" "0.983" "2581.7" "2521.5" "2777.8" "2372.0" "2468.8" "2617.8" "2604.4" "2286.9" "2634.1" "2536.6" "" "" "" "" "" "" "" "" "" "" "2581.7" "2133.3" "1756.4" "1729.6" "2022.7" "2032.9" "2007.6" "1966.3" "2056.1" "2280.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "47.999" "17" "12" "14" "12" "710" "80.3" "8.15" "48.35" "12" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "Endoderm differentiation" "RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex" "5" "0" "1.048" "0.939" "0.968" "1.010" "0.969" "1.069" "1.017" "0.866" "0.927" "784.3" "822.0" "736.7" "759.2" "791.9" "759.9" "838.2" "797.3" "679.1" "726.8" "" "" "" "" "" "" "" "" "" "" "784.3" "695.4" "465.8" "553.6" "648.8" "590.1" "646.1" "685.5" "530.1" "653.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "47.968" "18" "9" "14" "9" "509" "54.8" "5.59" "49.97" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Parkin-ubiquitin proteasomal system pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.022" "0.838" "0.990" "0.966" "0.795" "0.959" "0.974" "0.822" "0.953" "973.1" "994.4" "815.8" "963.6" "940.2" "773.7" "932.8" "947.7" "800.1" "927.3" "" "" "" "" "" "" "" "" "" "" "973.1" "841.3" "515.8" "702.6" "770.3" "600.8" "719.1" "814.9" "624.5" "833.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "47.961" "25" "5" "30" "5" "216" "24.4" "7.49" "103.21" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "11" "0" "0.915" "1.023" "0.914" "0.875" "1.016" "0.937" "0.949" "1.027" "1.056" "2053.3" "1879.6" "2100.8" "1877.2" "1796.7" "2086.2" "1924.5" "1947.7" "2109.0" "2168.6" "" "" "" "" "" "" "" "" "" "" "2053.3" "1590.2" "1328.4" "1368.7" "1472.0" "1620.1" "1483.4" "1674.6" "1646.2" "1949.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "47.953" "11" "8" "11" "7" "863" "98.2" "6.46" "41.00" "8" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "Lung fibrosis" "" "1" "1" "1.067" "1.092" "1.053" "1.123" "1.040" "0.991" "1.023" "1.090" "1.092" "351.0" "374.4" "383.2" "369.6" "394.0" "365.2" "348.0" "359.2" "382.5" "383.2" "" "" "" "" "" "" "" "" "" "" "351.0" "316.8" "242.3" "269.5" "322.8" "283.6" "268.3" "308.8" "298.6" "344.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "47.877" "29" "9" "20" "9" "329" "37.6" "5.33" "65.73" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "TGF-beta signaling pathway" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "1.068" "0.922" "0.967" "1.045" "0.884" "0.978" "1.063" "0.871" "1.035" "1011.3" "1079.9" "932.0" "978.4" "1057.0" "894.0" "989.5" "1075.5" "880.7" "1046.3" "" "" "" "" "" "" "" "" "" "" "1011.3" "913.6" "589.3" "713.4" "866.0" "694.3" "762.8" "924.7" "687.5" "940.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "47.861" "25" "6" "20" "6" "249" "28.7" "10.84" "67.46" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "49" "0" "1.030" "1.118" "0.979" "1.045" "1.132" "1.035" "1.192" "1.145" "1.047" "1236.6" "1273.4" "1382.4" "1210.3" "1291.8" "1400.1" "1279.6" "1474.3" "1415.9" "1294.7" "" "" "" "" "" "" "" "" "" "" "1236.6" "1077.4" "874.1" "882.5" "1058.4" "1087.3" "986.4" "1267.6" "1105.2" "1164.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "47.858" "8" "9" "15" "9" "1127" "128.1" "6.86" "50.83" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "11" "0" "0.976" "0.835" "0.994" "0.957" "0.918" "0.966" "0.984" "0.877" "0.935" "672.2" "656.2" "561.4" "668.3" "643.4" "617.2" "649.6" "661.4" "589.6" "628.3" "" "" "" "" "" "" "" "" "" "" "672.2" "555.2" "355.0" "487.3" "527.2" "479.3" "500.8" "568.6" "460.2" "564.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "47.849" "16" "11" "16" "11" "699" "78.7" "6.73" "50.14" "11" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "1.045" "0.881" "0.944" "1.015" "0.877" "1.020" "1.060" "0.830" "0.996" "590.2" "616.8" "519.9" "556.9" "599.4" "517.5" "602.1" "625.9" "489.7" "588.1" "" "" "" "" "" "" "" "" "" "" "590.2" "521.9" "328.7" "406.0" "491.1" "401.9" "464.1" "538.1" "382.2" "528.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "47.790" "14" "9" "12" "9" "729" "79.5" "5.22" "41.29" "9" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "1.077" "1.047" "1.069" "1.072" "1.000" "1.106" "1.043" "1.023" "1.019" "706.5" "761.2" "739.6" "754.9" "757.3" "706.2" "781.1" "737.0" "722.5" "719.6" "" "" "" "" "" "" "" "" "" "" "706.5" "644.0" "467.6" "550.5" "620.5" "548.4" "602.1" "633.7" "564.0" "647.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "47.782" "19" "7" "15" "7" "501" "58.8" "5.38" "54.07" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "Exercise-induced circadian regulation; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.142" "1.239" "1.078" "0.998" "1.281" "1.143" "1.054" "1.223" "1.121" "402.5" "459.5" "498.5" "433.9" "401.5" "515.7" "460.0" "424.4" "492.1" "451.3" "" "" "" "" "" "" "" "" "" "" "402.5" "388.7" "315.2" "316.4" "329.0" "400.5" "354.6" "364.9" "384.1" "405.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "47.757" "26" "6" "24" "5" "305" "30.8" "9.29" "67.74" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "0.981" "0.923" "1.079" "1.058" "0.897" "0.971" "0.926" "0.948" "0.927" "602.9" "591.6" "556.7" "650.5" "638.0" "540.9" "585.6" "558.3" "571.8" "558.7" "" "" "" "" "" "" "" "" "" "" "602.9" "500.5" "352.0" "474.3" "522.7" "420.0" "451.4" "480.0" "446.3" "502.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "47.751" "14" "5" "100" "1" "376" "42.0" "5.59" "313.81" "5" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "47.716" "6" "11" "13" "11" "2240" "243.7" "7.88" "43.49" "11" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "1.091" "1.141" "1.098" "1.114" "1.277" "1.081" "1.132" "1.230" "1.079" "677.0" "738.4" "772.3" "743.5" "754.1" "864.6" "732.1" "766.5" "832.8" "730.8" "" "" "" "" "" "" "" "" "" "" "677.0" "624.7" "488.3" "542.1" "617.9" "671.5" "564.3" "659.1" "650.0" "657.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "47.700" "26" "12" "16" "12" "474" "52.4" "5.92" "53.62" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "8" "0" "1.037" "1.112" "1.117" "1.035" "1.094" "1.075" "1.056" "1.070" "1.057" "855.2" "886.5" "950.7" "955.5" "884.8" "935.5" "919.6" "903.4" "915.3" "903.8" "" "" "" "" "" "" "" "" "" "" "855.2" "750.0" "601.2" "696.7" "724.9" "726.5" "708.9" "776.7" "714.5" "812.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "47.474" "27" "8" "37" "4" "285" "32.9" "4.72" "112.45" "8" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "7" "0" "1.025" "1.107" "1.158" "1.055" "1.156" "1.230" "1.072" "1.129" "1.201" "642.0" "657.9" "710.7" "743.3" "677.2" "742.3" "789.7" "688.5" "724.8" "770.8" "" "" "" "" "" "" "" "" "" "" "642.0" "556.6" "449.4" "541.9" "554.9" "576.4" "608.7" "592.0" "565.7" "693.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "47.436" "10" "14" "16" "13" "1341" "151.8" "6.43" "52.21" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "2" "1" "1.135" "1.713" "1.080" "1.116" "1.584" "1.134" "1.087" "1.655" "1.251" "774.7" "879.1" "1327.1" "836.6" "864.3" "1227.4" "878.7" "842.3" "1281.8" "969.1" "" "" "" "" "" "" "" "" "" "" "774.7" "743.8" "839.1" "610.0" "708.1" "953.1" "677.4" "724.2" "1000.5" "871.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "47.328" "28" "8" "12" "8" "421" "44.9" "7.52" "39.80" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "4" "0" "0.990" "0.957" "1.012" "0.999" "0.912" "1.009" "0.944" "0.928" "0.953" "478.9" "474.2" "458.2" "484.9" "478.6" "436.6" "483.4" "452.3" "444.4" "456.4" "" "" "" "" "" "" "" "" "" "" "478.9" "401.2" "289.8" "353.5" "392.1" "339.1" "372.6" "388.9" "346.9" "410.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "47.295" "21" "9" "15" "9" "483" "54.4" "8.66" "51.28" "9" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.080" "1.078" "1.001" "0.958" "0.996" "0.926" "0.924" "0.975" "1.059" "887.8" "958.8" "957.3" "888.4" "850.1" "884.3" "822.0" "820.2" "865.7" "940.2" "" "" "" "" "" "" "" "" "" "" "887.8" "811.2" "605.3" "647.8" "696.5" "686.7" "633.7" "705.2" "675.7" "845.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "47.282" "12" "13" "16" "13" "1019" "117.9" "6.61" "45.82" "13" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Peroxisomal protein import; Ub-specific processing proteases; Insulin receptor recycling" "5" "0" "1.001" "1.066" "1.006" "1.004" "1.048" "0.995" "1.034" "1.066" "1.049" "901.4" "902.2" "960.9" "907.2" "905.3" "945.0" "897.3" "932.1" "961.3" "945.3" "" "" "" "" "" "" "" "" "" "" "901.4" "763.3" "607.6" "661.5" "741.7" "733.9" "691.7" "801.4" "750.3" "849.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "47.129" "35" "7" "26" "6" "198" "21.9" "5.97" "87.51" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "6" "0" "1.036" "1.118" "0.963" "1.017" "1.031" "1.017" "1.017" "1.033" "1.028" "1360.1" "1408.8" "1520.8" "1310.3" "1382.9" "1402.1" "1383.7" "1383.0" "1405.5" "1397.8" "" "" "" "" "" "" "" "" "" "" "1360.1" "1191.9" "961.6" "955.4" "1133.0" "1088.9" "1066.6" "1189.1" "1097.0" "1256.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "46.990" "17" "9" "12" "9" "607" "70.3" "6.11" "45.06" "9" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "1.215" "0.760" "1.201" "1.045" "1.010" "1.115" "1.187" "0.786" "0.936" "134.5" "163.4" "102.3" "161.5" "140.5" "135.8" "149.9" "159.6" "105.7" "125.9" "" "" "" "" "" "" "" "" "" "" "134.5" "138.2" "64.7" "117.8" "115.2" "105.5" "115.6" "137.2" "82.5" "113.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746028524908130600" "False" "High" "IsMasterProtein" "P16070" "CD44 antigen OS=Homo sapiens OX=9606 GN=CD44 PE=1 SV=3" "0.000" "False" "46.981" "13" "8" "17" "8" "742" "81.5" "5.33" "52.17" "8" "cell adhesion;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00193" "960" "ENSG00000026508" "CD44" "A5YRN9; B6EAT9; D3DR12; D3DR13; hsa:960; O95370; P16070; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; Q13960; Q13961; Q13967; Q13968; Q13980; Q15861; Q16064; Q16065; Q16066; Q16208; Q16522; Q86T72; Q86Z27; Q8N694; Q92493; Q96J24; Q9H5A5; Q9UC28; Q9UC29; Q9UC30; Q9UCB0; Q9UJ36" "Hepatitis C and hepatocellular carcinoma; Wnt signaling pathway and pluripotency; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Pleural mesothelioma; CCL18 signaling pathway" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Degradation of the extracellular matrix; Integrin cell surface interactions; Interferon gamma signaling; Hyaluronan uptake and degradation" "12" "0" "0.909" "1.009" "1.031" "0.954" "0.997" "1.072" "1.031" "0.926" "0.968" "906.4" "824.2" "914.6" "934.9" "864.6" "903.4" "971.4" "934.4" "839.0" "877.0" "" "" "" "" "" "" "" "" "" "" "906.4" "697.3" "578.3" "681.7" "708.3" "701.6" "748.8" "803.4" "654.9" "788.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "46.946" "27" "11" "23" "3" "428" "49.0" "5.67" "63.94" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "" "mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "1.074" "0.881" "1.162" "1.003" "1.282" "1.056" "1.030" "1.205" "1.161" "71.1" "76.4" "62.6" "82.6" "71.3" "91.1" "75.0" "73.2" "85.6" "82.6" "" "" "" "" "" "" "" "" "" "" "71.1" "64.6" "39.6" "60.2" "58.4" "70.8" "57.8" "63.0" "66.9" "74.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "46.927" "20" "6" "13" "6" "374" "42.5" "5.63" "51.35" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "0.962" "0.928" "0.991" "0.918" "0.949" "0.950" "1.005" "1.025" "0.990" "468.6" "451.0" "434.7" "464.4" "430.2" "444.6" "445.1" "470.8" "480.3" "463.8" "" "" "" "" "" "" "" "" "" "" "468.6" "381.6" "274.9" "338.6" "352.5" "345.2" "343.1" "404.8" "374.9" "417.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170052287552769839" "False" "High" "IsMasterProtein" "Q13905" "Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3" "0.000" "False" "46.876" "11" "10" "14" "10" "1077" "120.5" "5.92" "44.36" "10" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "2889" "ENSG00000107263" "RAPGEF1" "hsa:2889; Q13905; Q5JUE4; Q68DL3; Q8IV73" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MET in type 1 papillary renal cell carcinoma; Insulin signaling; Interferon type I signaling pathways" "MET activates RAP1 and RAC1; RAC3 GTPase cycle; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation" "17" "0" "1.003" "0.900" "1.014" "1.018" "0.976" "1.001" "1.077" "0.969" "0.970" "634.6" "636.8" "571.1" "643.8" "646.0" "619.1" "635.4" "683.4" "614.7" "615.4" "" "" "" "" "" "" "" "" "" "" "634.6" "538.8" "361.1" "469.4" "529.3" "480.8" "489.8" "587.6" "479.8" "553.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.000" "False" "46.858" "7" "11" "15" "8" "1538" "169.3" "9.03" "44.89" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "17" "3" "1.036" "0.972" "1.056" "1.129" "1.087" "1.100" "1.169" "0.999" "0.987" "824.8" "854.8" "801.7" "870.6" "931.0" "896.1" "907.5" "964.0" "823.9" "814.2" "" "" "" "" "" "" "" "" "" "" "824.8" "723.2" "506.9" "634.8" "762.8" "695.9" "699.6" "828.8" "643.1" "732.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "46.715" "24" "9" "18" "9" "427" "45.2" "8.85" "60.74" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "7" "0" "0.949" "1.082" "0.846" "0.909" "1.095" "0.902" "0.960" "1.032" "1.061" "1201.3" "1140.5" "1300.2" "1016.4" "1091.6" "1315.6" "1083.6" "1153.4" "1240.2" "1274.5" "" "" "" "" "" "" "" "" "" "" "1201.3" "964.9" "822.1" "741.1" "894.4" "1021.7" "835.3" "991.7" "968.1" "1145.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "46.573" "19" "11" "20" "11" "531" "60.5" "9.61" "61.55" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Endoderm differentiation" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "7" "0" "0.995" "0.843" "1.011" "1.011" "0.913" "1.070" "1.001" "0.849" "0.968" "900.1" "895.6" "758.9" "910.2" "910.1" "822.2" "963.0" "901.1" "764.2" "871.1" "" "" "" "" "" "" "" "" "" "" "900.1" "757.7" "479.9" "663.6" "745.7" "638.5" "742.3" "774.8" "596.5" "783.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "46.457" "41" "7" "15" "7" "264" "29.2" "5.97" "54.02" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.963" "1.062" "0.992" "0.984" "1.006" "0.977" "0.962" "0.974" "0.972" "943.9" "908.5" "1002.4" "936.1" "928.7" "949.2" "921.7" "907.7" "919.0" "917.1" "" "" "" "" "" "" "" "" "" "" "943.9" "768.6" "633.8" "682.5" "760.9" "737.2" "710.5" "780.5" "717.3" "824.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "46.453" "22" "9" "16" "9" "475" "53.5" "5.25" "56.23" "9" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "Ciliopathies" "" "1" "0" "0.955" "0.824" "1.010" "0.975" "0.945" "1.005" "0.970" "0.897" "1.027" "699.2" "667.6" "576.2" "706.0" "681.6" "660.7" "702.8" "678.1" "627.5" "718.2" "" "" "" "" "" "" "" "" "" "" "699.2" "564.8" "364.3" "514.8" "558.4" "513.1" "541.7" "583.0" "489.8" "645.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "46.328" "17" "12" "18" "11" "668" "75.0" "9.66" "56.29" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "1" "1.066" "0.989" "1.022" "1.001" "0.942" "1.017" "1.039" "0.977" "1.021" "1241.5" "1323.2" "1228.1" "1269.1" "1243.1" "1170.0" "1262.1" "1289.5" "1212.7" "1267.4" "" "" "" "" "" "" "" "" "" "" "1241.5" "1119.5" "776.5" "925.3" "1018.4" "908.6" "972.9" "1108.7" "946.6" "1139.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "46.279" "18" "7" "14" "7" "514" "55.6" "5.55" "54.61" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Rett syndrome" "Heme signaling; Transcriptional activation of mitochondrial biogenesis; HCMV Early Events; HDACs deacetylate histones; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "20" "0" "1.022" "1.051" "0.944" "0.961" "1.078" "0.940" "0.997" "1.134" "1.017" "1264.0" "1292.1" "1328.3" "1193.1" "1214.6" "1362.6" "1188.3" "1260.8" "1433.5" "1285.5" "" "" "" "" "" "" "" "" "" "" "1264.0" "1093.2" "839.9" "869.9" "995.1" "1058.2" "916.0" "1084.1" "1118.9" "1155.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "46.243" "11" "8" "14" "8" "1023" "112.8" "5.49" "49.32" "8" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "6" "0" "1.065" "1.075" "1.137" "1.036" "1.042" "1.291" "1.101" "1.014" "1.174" "127.3" "135.6" "136.9" "144.8" "131.9" "132.6" "164.4" "140.2" "129.1" "149.4" "" "" "" "" "" "" "" "" "" "" "127.3" "114.7" "86.6" "105.5" "108.1" "103.0" "126.7" "120.5" "100.8" "134.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "46.208" "8" "12" "16" "12" "1507" "168.9" "5.06" "48.06" "12" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Hippo-Merlin signaling dysregulation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.118" "0.913" "1.099" "1.016" "0.951" "1.048" "1.055" "1.032" "1.021" "835.8" "934.1" "762.8" "918.7" "849.1" "794.7" "876.1" "881.6" "862.5" "853.3" "" "" "" "" "" "" "" "" "" "" "835.8" "790.3" "482.3" "669.9" "695.7" "617.2" "675.3" "758.0" "673.2" "767.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "46.142" "44" "5" "21" "5" "154" "15.9" "6.13" "76.27" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "17" "0" "0.938" "1.090" "0.977" "0.988" "1.112" "1.073" "0.936" "1.048" "0.994" "847.0" "794.5" "922.9" "827.3" "836.5" "941.8" "909.3" "792.9" "887.5" "842.2" "" "" "" "" "" "" "" "" "" "" "847.0" "672.2" "583.6" "603.2" "685.3" "731.3" "700.9" "681.7" "692.7" "757.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.000" "False" "46.141" "11" "11" "14" "11" "1047" "119.8" "5.66" "44.46" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "12" "0" "1.013" "1.398" "1.028" "1.182" "1.479" "1.103" "1.119" "1.382" "1.126" "659.3" "668.0" "921.5" "677.7" "779.5" "975.3" "727.1" "737.6" "911.2" "742.5" "" "" "" "" "" "" "" "" "" "" "659.3" "565.2" "582.7" "494.1" "638.7" "757.4" "560.5" "634.2" "711.3" "667.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "46.139" "25" "7" "14" "7" "349" "39.5" "6.84" "56.34" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "0.971" "1.031" "0.962" "0.925" "1.085" "0.903" "0.995" "1.038" "1.045" "622.6" "604.6" "641.9" "598.8" "575.7" "675.9" "562.0" "619.4" "646.5" "650.6" "" "" "" "" "" "" "" "" "" "" "622.6" "511.5" "405.9" "436.6" "471.6" "524.9" "433.2" "532.6" "504.6" "584.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "46.124" "34" "8" "13" "8" "339" "37.2" "4.74" "48.70" "8" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "1.044" "1.324" "1.051" "1.027" "1.307" "1.128" "1.068" "1.217" "1.084" "735.2" "767.2" "973.6" "772.9" "754.9" "961.3" "829.2" "785.3" "894.5" "797.0" "" "" "" "" "" "" "" "" "" "" "735.2" "649.1" "615.6" "563.5" "618.5" "746.5" "639.2" "675.2" "698.2" "716.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "46.103" "42" "6" "36" "6" "149" "16.8" "4.22" "123.34" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "" "17" "0" "0.928" "1.020" "0.919" "0.893" "1.014" "1.104" "0.902" "1.042" "0.904" "3022.2" "2803.3" "3082.8" "2776.4" "2700.2" "3064.7" "3335.5" "2725.4" "3150.2" "2732.2" "" "" "" "" "" "" "" "" "" "" "3022.2" "2371.7" "1949.3" "2024.4" "2212.3" "2380.0" "2571.1" "2343.3" "2458.9" "2456.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "45.970" "6" "10" "12" "7" "1785" "201.9" "6.33" "34.75" "10" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "2" "1.039" "0.931" "1.050" "0.979" "0.880" "1.008" "0.950" "0.861" "0.991" "633.8" "658.5" "590.0" "665.2" "620.8" "557.6" "639.0" "602.1" "545.8" "627.8" "" "" "" "" "" "" "" "" "" "" "633.8" "557.1" "373.1" "485.1" "508.6" "433.0" "492.6" "517.7" "426.0" "564.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "45.952" "25" "4" "18" "4" "282" "31.3" "4.84" "75.31" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "8" "0" "0.924" "1.076" "0.954" "0.971" "1.029" "1.068" "0.941" "1.038" "1.031" "1508.4" "1393.8" "1623.4" "1438.9" "1465.3" "1551.7" "1610.9" "1418.7" "1565.2" "1555.1" "" "" "" "" "" "" "" "" "" "" "1508.4" "1179.2" "1026.5" "1049.2" "1200.5" "1205.0" "1241.7" "1219.8" "1221.7" "1398.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "45.917" "48" "9" "19" "1" "201" "22.2" "5.73" "62.98" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "45.839" "13" "9" "10" "9" "793" "89.8" "7.56" "38.98" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "4" "0" "1.116" "0.876" "1.134" "1.127" "1.003" "1.161" "0.992" "1.034" "1.048" "343.8" "383.7" "301.0" "389.7" "387.6" "344.8" "399.1" "340.9" "355.3" "360.2" "" "" "" "" "" "" "" "" "" "" "343.8" "324.6" "190.3" "284.1" "317.5" "267.8" "307.7" "293.1" "277.3" "323.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "45.796" "14" "11" "15" "10" "864" "97.0" "5.58" "45.70" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "Neurexins and neuroligins" "4" "1" "1.094" "1.062" "1.084" "1.043" "1.065" "1.070" "1.072" "1.073" "1.097" "610.2" "667.9" "648.3" "661.2" "636.2" "650.1" "652.8" "654.1" "654.8" "669.5" "" "" "" "" "" "" "" "" "" "" "610.2" "565.1" "409.9" "482.1" "521.2" "504.9" "503.2" "562.4" "511.1" "601.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "45.686" "12" "7" "17" "4" "644" "70.7" "9.26" "56.56" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "0.908" "0.749" "0.961" "0.971" "0.703" "0.916" "0.968" "0.814" "0.915" "398.8" "362.1" "298.7" "383.4" "387.1" "280.2" "365.5" "386.2" "324.8" "365.1" "" "" "" "" "" "" "" "" "" "" "398.8" "306.3" "188.9" "279.6" "317.2" "217.6" "281.7" "332.1" "253.5" "328.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "45.621" "37" "13" "20" "13" "341" "39.8" "6.89" "59.93" "13" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "6" "0" "0.996" "0.992" "1.000" "0.974" "1.061" "0.955" "0.944" "1.025" "0.978" "1496.2" "1490.1" "1484.0" "1495.5" "1457.5" "1588.0" "1428.1" "1412.0" "1533.0" "1462.7" "" "" "" "" "" "" "" "" "" "" "1496.2" "1260.6" "938.4" "1090.4" "1194.1" "1233.2" "1100.9" "1214.0" "1196.6" "1315.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "45.594" "18" "7" "16" "7" "463" "51.8" "6.99" "57.21" "7" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "" "Neutrophil degranulation; COPII-mediated vesicle transport; Cargo concentration in the ER; MHC class II antigen presentation" "4" "0" "0.976" "1.074" "0.909" "0.968" "1.005" "0.869" "0.922" "1.100" "1.129" "542.2" "529.3" "582.5" "492.8" "524.9" "544.8" "470.9" "499.9" "596.1" "612.0" "" "" "" "" "" "" "" "" "" "" "542.2" "447.8" "368.3" "359.3" "430.1" "423.0" "363.0" "429.8" "465.3" "550.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "45.528" "37" "11" "15" "10" "325" "36.6" "6.79" "45.37" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Formation of xylulose-5-phosphate" "4" "0" "0.972" "0.967" "0.896" "0.954" "0.964" "0.905" "0.848" "0.928" "1.018" "964.7" "937.6" "933.0" "864.6" "920.5" "930.1" "872.6" "817.7" "895.5" "981.7" "" "" "" "" "" "" "" "" "" "" "964.7" "793.2" "590.0" "630.4" "754.2" "722.3" "672.6" "703.1" "699.0" "882.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "45.525" "13" "13" "18" "13" "903" "101.9" "8.22" "56.43" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "4" "0" "1.042" "0.975" "0.956" "1.021" "0.948" "0.972" "0.992" "1.002" "1.000" "1333.0" "1388.3" "1299.2" "1274.1" "1360.5" "1263.6" "1296.1" "1322.3" "1335.8" "1332.3" "" "" "" "" "" "" "" "" "" "" "1333.0" "1174.6" "821.5" "929.0" "1114.7" "981.3" "999.1" "1136.9" "1042.7" "1197.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "45.515" "11" "10" "14" "9" "978" "105.7" "8.06" "41.88" "10" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "3" "0" "1.106" "1.060" "1.013" "1.119" "1.101" "1.150" "1.127" "1.059" "1.146" "347.2" "384.1" "368.2" "351.6" "388.4" "382.3" "399.3" "391.2" "367.5" "397.7" "" "" "" "" "" "" "" "" "" "" "347.2" "325.0" "232.8" "256.3" "318.2" "296.9" "307.8" "336.4" "286.9" "357.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "45.476" "19" "10" "11" "10" "608" "68.1" "6.38" "40.87" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "" "Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "3" "0" "1.051" "1.039" "1.007" "0.951" "1.028" "0.963" "0.990" "1.075" "0.994" "871.5" "915.9" "905.3" "877.5" "828.5" "895.6" "839.5" "862.6" "937.2" "866.2" "" "" "" "" "" "" "" "" "" "" "871.5" "774.8" "572.4" "639.8" "678.8" "695.5" "647.1" "741.7" "731.5" "778.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "45.469" "22" "9" "15" "8" "410" "46.6" "7.37" "46.95" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "18" "0" "0.961" "0.976" "0.921" "0.938" "1.004" "0.929" "0.952" "0.991" "0.959" "853.6" "820.2" "832.9" "786.0" "800.7" "856.7" "793.3" "812.5" "845.5" "818.3" "" "" "" "" "" "" "" "" "" "" "853.6" "693.9" "526.7" "573.1" "656.0" "665.3" "611.5" "698.6" "660.0" "735.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "45.361" "28" "11" "16" "11" "396" "44.7" "7.81" "58.06" "11" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "" "Platelet degranulation" "1" "0" "0.921" "1.014" "0.902" "0.948" "0.978" "0.852" "0.952" "0.988" "0.919" "1162.0" "1070.1" "1177.9" "1048.0" "1101.3" "1136.2" "990.4" "1106.7" "1148.5" "1067.8" "" "" "" "" "" "" "" "" "" "" "1162.0" "905.4" "744.8" "764.2" "902.3" "882.3" "763.4" "951.5" "896.4" "960.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "45.355" "27" "10" "13" "10" "399" "44.2" "4.73" "42.32" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Telomere Extension By Telomerase; Removal of the Flap Intermediate from the C-strand" "16" "0" "1.039" "0.829" "1.041" "1.053" "0.911" "1.040" "0.997" "0.886" "0.990" "658.8" "684.3" "546.1" "685.9" "693.9" "600.3" "685.3" "656.7" "583.4" "652.0" "" "" "" "" "" "" "" "" "" "" "658.8" "578.9" "345.3" "500.1" "568.5" "466.2" "528.3" "564.6" "455.4" "586.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "45.353" "14" "8" "15" "8" "583" "63.4" "8.28" "44.98" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "1.040" "0.900" "1.039" "0.990" "0.970" "0.992" "1.004" "1.043" "1.005" "250.4" "260.5" "225.4" "260.1" "247.8" "242.9" "248.3" "251.5" "261.1" "251.6" "" "" "" "" "" "" "" "" "" "" "250.4" "220.4" "142.5" "189.7" "203.0" "188.7" "191.4" "216.2" "203.8" "226.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "45.329" "31" "6" "11" "6" "218" "24.6" "6.68" "39.00" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Mesodermal commitment pathway" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "4" "0" "1.026" "1.103" "1.035" "0.984" "1.057" "0.959" "0.997" "1.016" "1.006" "611.2" "627.1" "674.1" "632.4" "601.2" "646.2" "586.0" "609.4" "620.8" "615.0" "" "" "" "" "" "" "" "" "" "" "611.2" "530.5" "426.2" "461.1" "492.6" "501.8" "451.7" "524.0" "484.6" "552.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "45.322" "15" "11" "22" "7" "780" "85.0" "7.50" "65.68" "11" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Neutrophil degranulation" "9" "0" "1.115" "1.096" "1.067" "1.064" "1.090" "1.059" "1.044" "1.103" "1.088" "575.9" "642.4" "631.5" "614.4" "612.8" "627.7" "609.8" "601.4" "635.0" "626.9" "" "" "" "" "" "" "" "" "" "" "575.9" "543.5" "399.3" "448.0" "502.1" "487.5" "470.0" "517.1" "495.7" "563.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "45.244" "14" "10" "13" "9" "724" "83.5" "6.16" "43.39" "10" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; G alpha (q) signalling events; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "154" "1" "1.029" "0.994" "1.047" "1.079" "1.022" "1.006" "1.062" "1.028" "1.056" "609.7" "627.2" "606.1" "638.6" "657.9" "623.4" "613.2" "647.3" "627.1" "644.1" "" "" "" "" "" "" "" "" "" "" "609.7" "530.6" "383.3" "465.6" "539.0" "484.1" "472.7" "556.5" "489.5" "579.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "45.214" "4" "7" "9" "7" "1843" "211.2" "6.90" "33.37" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "" "Regulation of expression of SLITs and ROBOs; UCH proteinases; Ub-specific processing proteases; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "52" "0" "1.095" "1.079" "1.071" "0.990" "1.044" "1.072" "1.040" "1.045" "1.106" "241.4" "264.2" "260.4" "258.6" "239.0" "252.0" "258.8" "251.1" "252.2" "266.9" "" "" "" "" "" "" "" "" "" "" "241.4" "223.5" "164.6" "188.6" "195.8" "195.7" "199.5" "215.9" "196.8" "240.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "45.198" "17" "8" "10" "8" "584" "64.7" "7.65" "38.23" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "1.024" "0.892" "1.045" "1.028" "0.895" "0.963" "1.020" "0.896" "0.976" "527.8" "540.4" "470.7" "551.7" "542.8" "472.3" "508.1" "538.2" "473.0" "514.9" "" "" "" "" "" "" "" "" "" "" "527.8" "457.2" "297.6" "402.3" "444.8" "366.8" "391.7" "462.7" "369.2" "463.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "45.083" "8" "9" "11" "9" "1443" "160.8" "6.40" "37.62" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "7" "0" "1.003" "1.174" "0.935" "1.040" "1.211" "0.992" "1.032" "1.225" "0.959" "165.1" "165.6" "193.8" "154.3" "171.7" "199.9" "163.8" "170.4" "202.1" "158.3" "" "" "" "" "" "" "" "" "" "" "165.1" "140.1" "122.5" "112.5" "140.7" "155.2" "126.3" "146.5" "157.8" "142.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "45.081" "38" "8" "21" "7" "215" "23.9" "6.21" "67.81" "8" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "7" "0" "1.030" "1.192" "1.102" "1.014" "1.097" "1.028" "1.011" "1.147" "1.085" "805.2" "829.5" "959.7" "887.4" "816.5" "882.9" "827.4" "814.0" "923.4" "873.5" "" "" "" "" "" "" "" "" "" "" "805.2" "701.7" "606.8" "647.0" "669.0" "685.7" "637.8" "699.9" "720.8" "785.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "45.042" "13" "8" "11" "8" "800" "90.2" "6.13" "36.92" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.102" "1.235" "1.100" "1.098" "1.345" "1.259" "1.179" "1.280" "1.132" "520.7" "574.0" "643.2" "572.9" "571.9" "700.6" "655.8" "614.1" "666.6" "589.5" "" "" "" "" "" "" "" "" "" "" "520.7" "485.6" "406.7" "417.7" "468.6" "544.1" "505.5" "528.0" "520.3" "530.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "45.030" "11" "11" "17" "11" "1000" "111.0" "5.54" "51.80" "11" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "" "COPII-mediated vesicle transport" "1" "0" "1.088" "1.019" "1.060" "1.037" "0.967" "1.076" "1.039" "1.001" "1.026" "691.8" "752.8" "705.2" "733.3" "717.0" "668.9" "744.5" "718.9" "692.4" "709.9" "" "" "" "" "" "" "" "" "" "" "691.8" "636.9" "445.9" "534.7" "587.5" "519.5" "573.9" "618.1" "540.5" "638.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "44.974" "15" "10" "13" "10" "649" "70.6" "6.32" "43.87" "10" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "0.963" "1.035" "1.065" "1.071" "1.047" "0.966" "1.037" "1.120" "1.102" "735.1" "707.8" "761.0" "782.7" "787.6" "769.8" "710.2" "762.0" "823.3" "809.8" "" "" "" "" "" "" "" "" "" "" "735.1" "598.8" "481.2" "570.7" "645.3" "597.8" "547.4" "655.2" "642.6" "728.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "44.895" "31" "8" "22" "8" "261" "29.5" "7.72" "71.18" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.976" "1.007" "1.067" "0.981" "1.009" "0.960" "0.984" "0.976" "1.058" "574.7" "560.6" "578.5" "612.9" "563.8" "580.0" "551.9" "565.2" "560.9" "607.9" "" "" "" "" "" "" "" "" "" "" "574.7" "474.3" "365.8" "446.9" "461.9" "450.4" "425.5" "485.9" "437.8" "546.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "44.857" "13" "6" "7" "6" "582" "63.8" "9.32" "30.87" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "" "3" "0" "0.971" "1.706" "0.983" "0.997" "1.769" "1.071" "0.979" "1.683" "1.194" "687.3" "667.1" "1172.7" "675.8" "685.4" "1215.8" "735.9" "672.7" "1156.9" "820.9" "" "" "" "" "" "" "" "" "" "" "687.3" "564.4" "741.5" "492.8" "561.5" "944.2" "567.3" "578.4" "903.0" "738.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "44.832" "11" "11" "14" "2" "1341" "147.1" "4.81" "40.51" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "0.970" "0.885" "1.543" "1.087" "1.380" "1.157" "1.348" "0.857" "0.939" "30.5" "29.6" "27.0" "47.0" "33.1" "42.1" "35.3" "41.1" "26.1" "28.6" "" "" "" "" "" "" "" "" "" "" "30.5" "25.0" "17.1" "34.3" "27.1" "32.7" "27.2" "35.3" "20.4" "25.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "44.817" "22" "11" "18" "10" "411" "46.8" "6.73" "56.32" "11" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "0.986" "1.172" "0.958" "1.033" "1.172" "1.020" "1.007" "1.196" "1.085" "877.2" "865.2" "1028.5" "840.5" "905.7" "1028.0" "894.7" "883.4" "1049.5" "951.9" "" "" "" "" "" "" "" "" "" "" "877.2" "732.0" "650.3" "612.8" "742.0" "798.4" "689.7" "759.5" "819.2" "855.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "44.804" "21" "7" "9" "7" "380" "43.2" "9.33" "35.40" "7" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.046" "0.880" "1.006" "1.016" "1.021" "1.055" "1.012" "0.908" "1.012" "335.6" "351.1" "295.5" "337.7" "340.9" "342.5" "354.2" "339.7" "304.6" "339.8" "" "" "" "" "" "" "" "" "" "" "335.6" "297.0" "186.8" "246.3" "279.3" "266.0" "273.0" "292.1" "237.8" "305.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "44.776" "20" "7" "13" "7" "413" "46.2" "7.01" "49.75" "7" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "11" "0" "1.145" "1.157" "1.158" "1.114" "1.109" "1.105" "1.115" "1.147" "1.181" "329.3" "377.2" "381.2" "381.3" "366.9" "365.3" "364.0" "367.3" "377.9" "389.0" "" "" "" "" "" "" "" "" "" "" "329.3" "319.1" "241.0" "278.0" "300.6" "283.7" "280.6" "315.8" "295.0" "349.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "44.755" "40" "5" "17" "5" "151" "16.3" "5.67" "70.60" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "1.036" "0.989" "1.035" "0.994" "1.014" "1.057" "1.004" "1.081" "1.089" "978.9" "1014.1" "968.4" "1013.3" "972.5" "992.5" "1035.0" "982.7" "1058.4" "1066.2" "" "" "" "" "" "" "" "" "" "" "978.9" "858.0" "612.3" "738.9" "796.8" "770.8" "797.8" "844.9" "826.2" "958.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "44.693" "26" "6" "11" "6" "260" "30.5" "5.21" "43.65" "6" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "Pyrimidine salvage; Purine salvage" "4" "0" "1.027" "0.988" "1.005" "1.014" "0.974" "1.005" "1.029" "1.128" "1.082" "536.3" "551.0" "529.7" "538.9" "543.6" "522.2" "538.9" "551.7" "604.9" "580.2" "" "" "" "" "" "" "" "" "" "" "536.3" "466.1" "334.9" "393.0" "445.4" "405.6" "415.4" "474.4" "472.1" "521.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "44.648" "44" "6" "14" "6" "192" "21.2" "5.22" "39.09" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Release of apoptotic factors from the mitochondria; Pyroptosis; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "48" "0" "1.049" "0.818" "1.103" "1.127" "0.850" "1.044" "0.984" "0.835" "0.932" "475.9" "499.2" "389.1" "524.8" "536.1" "404.4" "496.7" "468.1" "397.5" "443.3" "" "" "" "" "" "" "" "" "" "" "475.9" "422.4" "246.0" "382.6" "439.3" "314.1" "382.9" "402.5" "310.3" "398.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "44.641" "10" "13" "15" "13" "1375" "157.2" "5.08" "43.77" "13" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "" "Ub-specific processing proteases" "1" "0" "1.141" "0.821" "1.115" "1.084" "0.902" "0.989" "1.035" "0.938" "1.049" "441.5" "503.9" "362.6" "492.4" "478.4" "398.2" "436.8" "457.1" "414.3" "462.9" "" "" "" "" "" "" "" "" "" "" "441.5" "426.3" "229.3" "359.0" "392.0" "309.2" "336.7" "393.0" "323.4" "416.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "44.578" "25" "9" "22" "9" "338" "38.3" "5.53" "71.30" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "" "1" "0" "0.951" "0.950" "0.871" "0.953" "0.895" "0.902" "0.966" "0.910" "0.885" "949.0" "902.5" "901.3" "826.9" "904.2" "849.6" "856.4" "916.2" "863.7" "840.3" "" "" "" "" "" "" "" "" "" "" "949.0" "763.6" "569.9" "602.9" "740.8" "659.8" "660.1" "787.8" "674.2" "755.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "44.530" "32" "6" "12" "6" "303" "33.8" "6.74" "47.25" "6" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "22" "0" "0.992" "0.947" "1.048" "0.983" "1.045" "1.047" "1.002" "0.968" "1.029" "470.0" "466.1" "445.1" "492.6" "461.8" "490.9" "492.2" "470.7" "454.8" "483.8" "" "" "" "" "" "" "" "" "" "" "470.0" "394.4" "281.4" "359.2" "378.3" "381.3" "379.4" "404.7" "355.0" "434.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563724113440254403" "False" "High" "IsMasterProtein" "Q7Z6J4" "FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1" "0.000" "False" "44.476" "15" "9" "14" "9" "655" "74.8" "6.93" "44.65" "9" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "221472" "ENSG00000146192" "FGD2" "hsa:221472; Q5T8I1; Q6P6A8; Q6ZNL5; Q7Z6J4; Q8IZ32; Q8N868; Q9H7M2" "" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "3" "0" "1.050" "0.860" "1.029" "1.056" "0.756" "0.933" "1.081" "0.817" "0.926" "421.7" "442.8" "362.6" "433.7" "445.3" "318.9" "393.2" "455.8" "344.7" "390.3" "" "" "" "" "" "" "" "" "" "" "421.7" "374.6" "229.3" "316.2" "364.9" "247.6" "303.1" "391.9" "269.1" "350.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "44.458" "45" "6" "21" "6" "172" "19.8" "4.84" "57.92" "6" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "9" "0" "1.067" "1.079" "1.061" "1.137" "1.084" "1.349" "1.027" "1.025" "1.059" "930.7" "993.1" "1004.0" "987.2" "1058.1" "1008.9" "1255.8" "956.3" "953.6" "986.1" "" "" "" "" "" "" "" "" "" "" "930.7" "840.2" "634.8" "719.8" "866.9" "783.5" "968.0" "822.2" "744.3" "886.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "44.455" "21" "8" "10" "8" "489" "54.3" "6.83" "36.08" "8" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "" "Mitochondrial protein import; Processing of SMDT1" "2" "0" "1.136" "1.193" "1.106" "1.176" "1.244" "1.124" "1.089" "1.062" "1.076" "244.4" "277.7" "291.5" "270.3" "287.3" "304.1" "274.8" "266.1" "259.4" "262.9" "" "" "" "" "" "" "" "" "" "" "244.4" "234.9" "184.3" "197.1" "235.4" "236.1" "211.8" "228.8" "202.5" "236.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "44.431" "26" "6" "26" "6" "239" "27.4" "5.73" "87.91" "6" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Proteasome degradation" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Interleukin-1 signaling; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of RUNX3 expression and activity" "61" "0" "0.966" "1.046" "0.951" "0.972" "0.934" "0.945" "0.924" "0.959" "0.915" "1806.6" "1744.7" "1888.9" "1718.6" "1755.4" "1688.0" "1706.4" "1670.0" "1731.7" "1652.3" "" "" "" "" "" "" "" "" "" "" "1806.6" "1476.1" "1194.4" "1253.1" "1438.2" "1310.9" "1315.3" "1435.9" "1351.7" "1485.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "44.411" "33" "6" "18" "5" "180" "20.5" "7.14" "54.92" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium" "4" "1" "0.990" "0.947" "1.065" "0.963" "0.927" "0.988" "1.053" "0.931" "0.953" "807.2" "799.3" "764.5" "859.5" "777.2" "748.3" "797.3" "850.0" "751.9" "768.9" "" "" "" "" "" "" "" "" "" "" "807.2" "676.2" "483.4" "626.7" "636.8" "581.1" "614.6" "730.8" "586.9" "691.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "44.354" "20" "9" "12" "9" "523" "56.5" "6.42" "40.24" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MHC class II antigen presentation; Neutrophil degranulation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy" "16" "0" "0.960" "0.924" "1.047" "1.011" "1.046" "1.064" "1.019" "0.958" "1.064" "673.1" "646.4" "622.0" "704.6" "680.6" "704.3" "716.2" "686.0" "644.9" "716.4" "" "" "" "" "" "" "" "" "" "" "673.1" "546.9" "393.3" "513.7" "557.6" "547.0" "552.1" "589.8" "503.4" "644.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "44.222" "40" "6" "20" "4" "151" "16.9" "4.65" "56.85" "6" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Ciliary landscape" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "2" "1.081" "1.067" "1.028" "1.161" "1.088" "1.274" "1.076" "0.986" "1.136" "680.1" "734.9" "725.5" "699.2" "789.7" "739.8" "866.7" "732.1" "670.7" "772.5" "" "" "" "" "" "" "" "" "" "" "680.1" "621.7" "458.8" "509.8" "647.0" "574.5" "668.1" "629.5" "523.5" "694.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "44.177" "9" "8" "10" "8" "1318" "145.6" "6.28" "33.50" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "1.003" "0.961" "1.172" "1.069" "0.932" "1.078" "1.053" "0.920" "0.978" "264.0" "264.7" "253.7" "309.4" "282.3" "246.0" "284.7" "278.1" "242.8" "258.2" "" "" "" "" "" "" "" "" "" "" "264.0" "223.9" "160.4" "225.6" "231.3" "191.1" "219.4" "239.1" "189.5" "232.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "44.175" "5" "12" "12" "7" "2603" "274.1" "6.52" "39.10" "12" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "1.095" "0.955" "1.135" "1.140" "0.843" "1.143" "1.055" "0.965" "1.097" "270.0" "295.7" "257.9" "306.5" "307.6" "227.6" "308.5" "284.8" "260.4" "296.2" "" "" "" "" "" "" "" "" "" "" "270.0" "250.2" "163.1" "223.5" "252.1" "176.7" "237.8" "244.9" "203.3" "266.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "44.131" "12" "14" "15" "14" "1174" "133.8" "6.87" "44.36" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "1.029" "0.912" "1.021" "1.017" "0.910" "1.052" "1.017" "0.931" "0.991" "1135.1" "1167.6" "1035.1" "1158.7" "1154.8" "1033.0" "1194.2" "1154.7" "1056.3" "1125.2" "" "" "" "" "" "" "" "" "" "" "1135.1" "987.8" "654.5" "844.8" "946.1" "802.2" "920.5" "992.8" "824.5" "1011.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "44.060" "26" "8" "13" "8" "292" "33.5" "4.84" "50.51" "8" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "0.993" "1.033" "0.929" "0.999" "1.020" "1.135" "1.011" "0.966" "0.966" "1008.0" "1000.6" "1040.8" "936.2" "1006.9" "1027.9" "1144.5" "1018.7" "974.0" "973.5" "" "" "" "" "" "" "" "" "" "" "1008.0" "846.5" "658.1" "682.6" "825.0" "798.2" "882.2" "875.9" "760.3" "875.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "43.945" "22" "8" "14" "8" "350" "37.9" "8.73" "50.54" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "4" "0" "1.027" "1.030" "1.066" "1.060" "1.002" "1.051" "1.035" "1.004" "1.017" "835.8" "858.7" "860.7" "890.7" "885.9" "837.3" "878.4" "865.0" "839.3" "850.4" "" "" "" "" "" "" "" "" "" "" "835.8" "726.5" "544.2" "649.4" "725.9" "650.2" "677.1" "743.7" "655.1" "764.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.000" "False" "43.876" "8" "9" "16" "9" "1450" "162.1" "6.23" "51.03" "9" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "1.106" "0.856" "1.076" "1.181" "0.910" "1.024" "1.120" "0.937" "1.005" "218.1" "241.1" "186.7" "234.7" "257.5" "198.4" "223.3" "244.3" "204.4" "219.3" "" "" "" "" "" "" "" "" "" "" "218.1" "204.0" "118.1" "171.2" "211.0" "154.1" "172.1" "210.1" "159.5" "197.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "43.852" "14" "8" "10" "8" "805" "90.3" "5.40" "35.83" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "6" "0" "1.164" "0.751" "1.011" "1.009" "0.792" "1.009" "0.897" "0.795" "0.954" "343.1" "399.4" "257.7" "347.1" "346.3" "271.8" "346.2" "307.8" "272.8" "327.5" "" "" "" "" "" "" "" "" "" "" "343.1" "337.9" "162.9" "253.1" "283.8" "211.1" "266.9" "264.7" "212.9" "294.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "43.792" "29" "6" "15" "6" "342" "36.7" "5.17" "49.25" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "" "RMTs methylate histone arginines; snRNP Assembly" "2" "0" "0.991" "0.921" "1.027" "1.034" "0.891" "0.990" "0.978" "0.871" "0.998" "484.4" "480.1" "446.1" "497.6" "501.0" "431.6" "479.3" "473.8" "421.8" "483.6" "" "" "" "" "" "" "" "" "" "" "484.4" "406.2" "282.1" "362.8" "410.4" "335.2" "369.5" "407.3" "329.2" "434.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "43.722" "18" "5" "10" "5" "335" "37.4" "5.39" "35.05" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "" "Iron uptake and transport" "1" "0" "0.944" "0.932" "0.998" "0.953" "0.880" "0.966" "0.923" "0.864" "0.990" "764.8" "722.2" "712.9" "763.5" "729.0" "673.0" "738.9" "705.5" "660.9" "757.2" "" "" "" "" "" "" "" "" "" "" "764.8" "611.0" "450.8" "556.7" "597.3" "522.6" "569.6" "606.6" "515.9" "680.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "43.577" "11" "14" "19" "14" "1150" "132.7" "5.76" "56.54" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.953" "1.108" "1.008" "1.007" "1.085" "1.050" "1.042" "1.103" "0.992" "594.4" "566.4" "658.7" "599.3" "598.6" "645.0" "623.9" "619.6" "655.6" "589.5" "" "" "" "" "" "" "" "" "" "" "594.4" "479.2" "416.5" "437.0" "490.4" "500.9" "480.9" "532.7" "511.7" "530.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "43.523" "17" "7" "13" "7" "523" "57.5" "9.38" "46.14" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.997" "0.989" "0.917" "1.126" "0.963" "1.104" "1.023" "0.939" "1.026" "223.9" "223.2" "221.4" "205.2" "252.1" "215.6" "247.2" "228.9" "210.3" "229.8" "" "" "" "" "" "" "" "" "" "" "223.9" "188.8" "140.0" "149.7" "206.5" "167.4" "190.5" "196.8" "164.1" "206.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "43.500" "24" "10" "19" "10" "431" "49.2" "5.58" "52.30" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "4" "0" "1.052" "1.015" "1.040" "1.018" "1.001" "1.020" "1.023" "0.970" "1.011" "1284.5" "1351.0" "1303.6" "1335.7" "1307.2" "1285.8" "1310.4" "1314.1" "1245.7" "1298.0" "" "" "" "" "" "" "" "" "" "" "1284.5" "1143.0" "824.3" "973.9" "1071.0" "998.5" "1010.1" "1129.8" "972.3" "1167.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "43.480" "23" "9" "16" "9" "480" "53.1" "6.19" "49.51" "9" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "VEGFA-VEGFR2 signaling" "Viral mRNA Translation; Mitochondrial RNA degradation" "3" "0" "1.039" "0.854" "0.974" "1.084" "0.825" "0.945" "1.026" "0.900" "1.021" "665.7" "691.7" "568.6" "648.7" "721.7" "549.5" "629.3" "683.3" "599.4" "679.6" "" "" "" "" "" "" "" "" "" "" "665.7" "585.2" "359.5" "473.0" "591.3" "426.7" "485.1" "587.5" "467.9" "611.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "43.401" "8" "6" "8" "6" "1129" "125.9" "5.62" "32.47" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "Mesodermal commitment pathway" "" "1" "0" "1.020" "0.886" "0.989" "1.003" "0.860" "0.981" "0.914" "0.871" "0.990" "622.3" "635.0" "551.2" "615.2" "623.8" "535.1" "610.4" "569.0" "541.8" "615.9" "" "" "" "" "" "" "" "" "" "" "622.3" "537.2" "348.5" "448.6" "511.1" "415.6" "470.5" "489.2" "422.9" "553.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "43.370" "9" "12" "14" "12" "1290" "148.4" "6.05" "46.92" "12" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; ISG15 antiviral mechanism; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "76" "0" "1.018" "0.877" "1.019" "1.021" "0.965" "0.979" "1.033" "0.924" "0.999" "609.8" "620.6" "534.6" "621.2" "622.7" "588.8" "596.8" "630.0" "563.4" "609.3" "" "" "" "" "" "" "" "" "" "" "609.8" "525.1" "338.0" "452.9" "510.2" "457.2" "460.0" "541.7" "439.7" "547.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8283014115765105916" "False" "High" "IsMasterProtein" "Q9UP83" "Conserved oligomeric Golgi complex subunit 5 OS=Homo sapiens OX=9606 GN=COG5 PE=1 SV=4" "0.000" "False" "43.326" "13" "10" "10" "10" "860" "94.8" "6.60" "33.05" "10" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf10392, Pf20649" "10466" "ENSG00000164597" "COG5" "A4D0R6; A4D0R7; hsa:10466; O14555; O95008; Q6NUL5; Q9UP83" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport" "3" "0" "1.031" "0.846" "1.054" "1.081" "0.850" "1.041" "1.046" "0.843" "0.978" "507.3" "522.8" "429.1" "534.6" "548.4" "431.0" "527.8" "530.6" "427.8" "495.9" "" "" "" "" "" "" "" "" "" "" "507.3" "442.3" "271.3" "389.8" "449.3" "334.7" "406.9" "456.2" "334.0" "445.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "43.319" "15" "7" "11" "7" "527" "59.7" "7.39" "35.61" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "12" "0" "1.033" "1.042" "1.131" "1.079" "1.030" "1.093" "1.076" "1.081" "1.083" "514.8" "531.7" "536.3" "582.3" "555.5" "530.4" "562.9" "554.1" "556.5" "557.5" "" "" "" "" "" "" "" "" "" "" "514.8" "449.8" "339.1" "424.6" "455.1" "411.9" "433.9" "476.4" "434.4" "501.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "43.290" "21" "5" "13" "4" "307" "35.1" "5.06" "43.91" "5" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "1.066" "1.139" "1.034" "1.033" "1.126" "1.197" "1.101" "0.980" "1.052" "139.7" "148.9" "159.1" "144.4" "144.4" "157.4" "167.2" "153.7" "136.8" "146.9" "" "" "" "" "" "" "" "" "" "" "139.7" "126.0" "100.6" "105.3" "118.3" "122.2" "128.9" "132.2" "106.8" "132.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "43.223" "7" "12" "14" "12" "1817" "197.5" "6.40" "43.72" "12" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "" "1" "0" "1.026" "0.895" "1.044" "1.047" "1.003" "1.075" "1.094" "0.942" "0.991" "972.2" "997.5" "869.8" "1014.7" "1017.5" "975.2" "1045.0" "1064.0" "915.9" "963.4" "" "" "" "" "" "" "" "" "" "" "972.2" "843.9" "550.0" "739.9" "833.6" "757.3" "805.5" "914.8" "714.9" "866.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "43.161" "27" "7" "12" "7" "293" "32.8" "7.50" "39.65" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Ciliary landscape" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.110" "1.071" "1.003" "0.945" "0.946" "0.888" "0.919" "1.043" "0.983" "559.4" "621.0" "599.3" "561.1" "528.4" "529.2" "497.0" "513.9" "583.6" "549.8" "" "" "" "" "" "" "" "" "" "" "559.4" "525.4" "378.9" "409.2" "432.9" "410.9" "383.1" "441.9" "455.5" "494.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "43.161" "20" "6" "17" "6" "357" "37.5" "5.45" "62.82" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "0.984" "1.045" "1.047" "1.013" "1.027" "1.010" "1.078" "1.068" "1.008" "888.2" "873.6" "928.2" "929.7" "899.5" "912.5" "896.9" "957.6" "948.4" "895.5" "" "" "" "" "" "" "" "" "" "" "888.2" "739.1" "586.9" "677.9" "737.0" "708.6" "691.4" "823.3" "740.3" "805.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "43.081" "11" "8" "13" "8" "802" "92.2" "8.18" "43.95" "8" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "" "mRNA Splicing - Major Pathway" "1" "0" "1.044" "1.245" "1.033" "1.003" "1.275" "1.021" "1.081" "1.203" "1.126" "407.8" "425.5" "507.6" "421.4" "409.1" "519.8" "416.4" "440.8" "490.4" "459.2" "" "" "" "" "" "" "" "" "" "" "407.8" "360.0" "321.0" "307.3" "335.2" "403.6" "321.0" "379.0" "382.8" "412.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "43.056" "38" "5" "106" "5" "128" "14.7" "9.83" "326.62" "5" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "DNA replication; Cytoplasmic ribosomal proteins" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); FCERI mediated NF-kB activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); Signaling by CSF1 (M-CSF) in myeloid cells; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "199" "0" "0.936" "1.045" "0.936" "0.979" "1.055" "1.120" "0.933" "0.979" "0.998" "5442.2" "5092.8" "5688.7" "5095.9" "5327.7" "5742.1" "6095.0" "5080.3" "5329.5" "5433.4" "" "" "" "" "" "" "" "" "" "" "5442.2" "4308.7" "3597.0" "3715.6" "4365.0" "4459.2" "4698.3" "4368.0" "4160.0" "4884.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "43.045" "36" "4" "9" "4" "183" "20.3" "4.72" "37.79" "4" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "1.021" "1.248" "1.006" "1.068" "1.139" "1.080" "1.058" "1.053" "0.935" "419.8" "428.6" "524.0" "422.5" "448.3" "478.4" "453.6" "444.2" "441.9" "392.5" "" "" "" "" "" "" "" "" "" "" "419.8" "362.6" "331.3" "308.1" "367.3" "371.5" "349.6" "381.9" "344.9" "352.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "43.032" "24" "7" "14" "7" "361" "40.8" "5.25" "51.35" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "1.012" "1.001" "1.081" "1.036" "1.001" "1.035" "1.005" "0.994" "1.032" "467.7" "473.4" "468.0" "505.6" "484.7" "468.3" "483.9" "470.0" "465.1" "482.8" "" "" "" "" "" "" "" "" "" "" "467.7" "400.5" "295.9" "368.6" "397.1" "363.6" "373.0" "404.1" "363.1" "434.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "42.974" "14" "7" "15" "3" "524" "59.0" "5.91" "47.36" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "16" "0" "1.298" "0.983" "1.251" "1.140" "1.035" "1.116" "1.220" "1.050" "1.131" "148.1" "192.3" "145.6" "185.3" "168.9" "153.3" "165.3" "180.6" "155.5" "167.5" "" "" "" "" "" "" "" "" "" "" "148.1" "162.7" "92.1" "135.1" "138.4" "119.0" "127.4" "155.3" "121.4" "150.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "42.966" "5" "14" "14" "14" "2610" "289.2" "5.35" "41.36" "14" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.950" "0.789" "0.939" "0.983" "0.796" "1.011" "0.978" "0.796" "0.854" "548.7" "521.5" "432.9" "515.3" "539.6" "436.9" "554.9" "536.6" "436.5" "468.7" "" "" "" "" "" "" "" "" "" "" "548.7" "441.2" "273.7" "375.7" "442.1" "339.3" "427.7" "461.4" "340.8" "421.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "42.924" "14" "10" "13" "9" "761" "84.3" "6.80" "44.63" "10" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOJ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "12" "0" "0.846" "0.927" "0.840" "0.870" "0.927" "0.871" "0.891" "0.866" "0.884" "598.4" "506.1" "554.7" "502.7" "520.3" "554.9" "521.4" "533.2" "518.4" "528.9" "" "" "" "" "" "" "" "" "" "" "598.4" "428.2" "350.7" "366.6" "426.3" "430.9" "401.9" "458.5" "404.7" "475.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "42.924" "21" "10" "21" "10" "466" "51.7" "8.32" "63.93" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "1.056" "1.200" "1.021" "1.036" "1.023" "0.956" "1.027" "1.098" "1.066" "845.5" "893.2" "1014.6" "863.5" "875.8" "865.1" "807.9" "868.3" "928.5" "901.7" "" "" "" "" "" "" "" "" "" "" "845.5" "755.7" "641.6" "629.6" "717.5" "671.8" "622.8" "746.5" "724.7" "810.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "42.895" "22" "7" "9" "7" "412" "45.5" "6.42" "35.42" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.026" "0.897" "1.106" "1.072" "0.912" "1.090" "1.082" "0.914" "1.022" "632.2" "648.7" "567.2" "699.4" "677.7" "576.7" "689.3" "684.1" "577.7" "646.2" "" "" "" "" "" "" "" "" "" "" "632.2" "548.8" "358.6" "509.9" "555.3" "447.8" "531.4" "588.2" "450.9" "580.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "42.892" "35" "7" "12" "7" "282" "31.4" "7.02" "45.43" "7" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Phase I biotransformations, non-P450" "Glutathione conjugation" "2" "0" "0.854" "0.929" "0.883" "0.920" "1.006" "0.838" "0.881" "1.014" "0.981" "981.4" "837.8" "911.8" "866.1" "902.9" "987.2" "822.4" "864.9" "994.9" "963.2" "" "" "" "" "" "" "" "" "" "" "981.4" "708.8" "576.5" "631.5" "739.7" "766.7" "634.0" "743.7" "776.6" "865.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "42.882" "8" "9" "11" "9" "1273" "145.1" "7.25" "38.85" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; Regulation of lipid metabolism by PPARalpha; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "19" "0" "0.945" "0.931" "0.982" "1.004" "0.916" "1.033" "1.061" "0.967" "0.968" "400.7" "378.4" "373.1" "393.5" "402.3" "367.1" "413.7" "425.2" "387.5" "387.7" "" "" "" "" "" "" "" "" "" "" "400.7" "320.2" "235.9" "286.9" "329.6" "285.0" "318.9" "365.6" "302.4" "348.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "42.840" "9" "6" "12" "6" "709" "78.3" "5.25" "40.59" "6" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "0.896" "1.177" "0.953" "0.980" "1.223" "1.039" "0.911" "1.193" "1.096" "879.3" "787.4" "1035.2" "837.7" "862.1" "1075.6" "913.8" "801.3" "1049.1" "964.1" "" "" "" "" "" "" "" "" "" "" "879.3" "666.2" "654.6" "610.8" "706.3" "835.3" "704.4" "688.9" "818.9" "866.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "42.806" "38" "8" "13" "8" "222" "25.1" "4.70" "49.45" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "" "HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.963" "0.975" "1.041" "1.040" "1.023" "1.150" "1.040" "0.969" "1.001" "1279.1" "1232.2" "1246.8" "1331.8" "1330.3" "1308.7" "1470.7" "1329.7" "1239.2" "1280.9" "" "" "" "" "" "" "" "" "" "" "1279.1" "1042.5" "788.4" "971.1" "1089.9" "1016.3" "1133.7" "1143.3" "967.3" "1151.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "42.787" "25" "8" "15" "8" "358" "40.5" "6.18" "48.01" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "Photodynamic therapy-induced unfolded protein response" "XBP1(S) activates chaperone genes" "2" "0" "1.073" "0.944" "1.053" "1.156" "0.966" "1.158" "1.270" "0.924" "1.063" "383.7" "411.8" "362.2" "404.2" "443.7" "370.6" "444.3" "487.4" "354.6" "407.8" "" "" "" "" "" "" "" "" "" "" "383.7" "348.4" "229.0" "294.7" "363.5" "287.8" "342.5" "419.0" "276.8" "366.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "42.784" "18" "10" "17" "10" "563" "65.1" "5.05" "54.07" "10" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.142" "1.113" "1.021" "1.059" "0.965" "0.916" "0.952" "1.056" "1.014" "979.5" "1118.6" "1090.5" "999.9" "1036.9" "945.4" "897.3" "932.7" "1033.9" "992.7" "" "" "" "" "" "" "" "" "" "" "979.5" "946.4" "689.5" "729.1" "849.5" "734.2" "691.6" "801.9" "807.0" "892.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "42.772" "18" "8" "10" "8" "517" "57.4" "6.76" "37.57" "8" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "3" "0" "1.167" "1.114" "1.162" "1.058" "1.166" "1.078" "1.143" "1.083" "1.125" "435.3" "507.8" "484.9" "505.9" "460.8" "507.6" "469.4" "497.6" "471.5" "489.9" "" "" "" "" "" "" "" "" "" "" "435.3" "429.6" "306.6" "368.9" "377.5" "394.2" "361.8" "427.8" "368.0" "440.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "42.746" "43" "5" "13" "5" "158" "18.0" "6.74" "56.19" "5" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.084" "0.966" "1.074" "1.055" "0.913" "1.099" "1.023" "0.980" "1.046" "640.2" "693.8" "618.5" "687.4" "675.1" "584.5" "703.8" "655.0" "627.2" "670.0" "" "" "" "" "" "" "" "" "" "" "640.2" "587.0" "391.1" "501.2" "553.2" "453.9" "542.5" "563.2" "489.6" "602.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "42.741" "9" "9" "13" "9" "1060" "118.6" "9.19" "45.38" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "1.120" "1.100" "1.046" "1.221" "1.096" "1.166" "1.099" "1.124" "1.122" "433.0" "485.2" "476.3" "453.1" "528.9" "474.7" "505.0" "475.7" "486.8" "485.9" "" "" "" "" "" "" "" "" "" "" "433.0" "410.5" "301.2" "330.4" "433.4" "368.7" "389.3" "409.0" "380.0" "436.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "42.646" "33" "8" "21" "8" "248" "27.7" "10.36" "63.73" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.017" "1.144" "0.956" "1.101" "1.298" "1.191" "1.129" "1.199" "1.163" "1211.6" "1232.5" "1386.2" "1158.5" "1334.4" "1573.1" "1443.2" "1367.5" "1453.1" "1409.2" "" "" "" "" "" "" "" "" "" "" "1211.6" "1042.7" "876.5" "844.7" "1093.2" "1221.6" "1112.4" "1175.7" "1134.3" "1266.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "42.624" "25" "9" "16" "8" "432" "47.6" "5.97" "57.21" "9" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis" "4" "0" "1.055" "1.015" "1.018" "1.077" "1.035" "1.018" "1.037" "1.001" "1.096" "852.8" "899.4" "865.4" "868.1" "918.1" "882.9" "868.4" "884.7" "853.6" "934.8" "" "" "" "" "" "" "" "" "" "" "852.8" "761.0" "547.2" "632.9" "752.2" "685.7" "669.4" "760.7" "666.3" "840.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "42.571" "21" "10" "15" "9" "476" "54.8" "6.61" "45.86" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "mRNA processing; 15q25 copy number variation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "1.065" "1.065" "0.952" "1.033" "1.063" "1.029" "1.040" "1.078" "1.027" "624.4" "664.7" "665.2" "594.2" "644.9" "663.8" "642.4" "649.1" "672.9" "641.2" "" "" "" "" "" "" "" "" "" "" "624.4" "562.3" "420.6" "433.2" "528.4" "515.5" "495.2" "558.1" "525.2" "576.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "42.488" "14" "14" "17" "14" "843" "96.6" "6.86" "49.69" "14" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "IL-18 signaling pathway; Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "4" "0" "0.986" "0.990" "1.020" "0.999" "1.064" "1.041" "1.037" "1.051" "1.038" "1005.4" "991.2" "995.2" "1025.7" "1004.5" "1069.6" "1046.4" "1042.7" "1057.0" "1043.7" "" "" "" "" "" "" "" "" "" "" "1005.4" "838.5" "629.3" "747.9" "823.0" "830.7" "806.6" "896.5" "825.0" "938.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3013944943172909164" "False" "High" "IsMasterProtein" "A0MZ66" "Shootin-1 OS=Homo sapiens OX=9606 GN=SHTN1 PE=1 SV=4" "0.000" "False" "42.432" "17" "10" "14" "10" "631" "71.6" "5.33" "37.55" "10" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "57698" "ENSG00000187164" "SHTN1" "A0MZ66; A8MYU7; B3KRD3; B3KRH2; B3KTE0; B3KTJ7; B3KTJ8; B4E3U1; B7Z7Z9; hsa:57698; Q68DG1; Q6PIM5; Q9HCH4; Q9NUV0" "" "Recycling pathway of L1" "1" "0" "1.043" "0.899" "1.067" "0.992" "0.921" "1.078" "1.025" "0.924" "0.980" "595.1" "620.9" "535.0" "635.0" "590.2" "548.2" "641.7" "610.1" "549.7" "583.4" "" "" "" "" "" "" "" "" "" "" "595.1" "525.3" "338.3" "463.0" "483.5" "425.7" "494.6" "524.5" "429.0" "524.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "42.423" "20" "9" "15" "9" "452" "51.3" "8.32" "47.10" "9" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "" "Mitochondrial protein import" "1" "0" "0.930" "0.991" "1.004" "0.985" "0.948" "1.030" "1.030" "0.938" "0.918" "928.9" "864.1" "920.6" "932.8" "914.8" "880.7" "956.4" "956.6" "870.9" "852.8" "" "" "" "" "" "" "" "" "" "" "928.9" "731.1" "582.1" "680.1" "749.5" "684.0" "737.2" "822.5" "679.8" "766.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "42.401" "24" "12" "15" "12" "521" "56.7" "7.99" "42.85" "12" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "IL-18 signaling pathway; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "5" "0" "0.984" "0.902" "0.953" "0.974" "0.883" "1.005" "0.997" "0.894" "0.887" "810.5" "797.5" "730.8" "772.7" "789.4" "715.5" "814.9" "808.1" "724.9" "718.7" "" "" "" "" "" "" "" "" "" "" "810.5" "674.7" "462.1" "563.4" "646.7" "555.7" "628.2" "694.8" "565.9" "646.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "42.395" "14" "9" "11" "9" "625" "68.2" "6.42" "37.64" "9" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.972" "1.071" "1.000" "1.071" "1.079" "1.077" "1.071" "1.005" "0.897" "570.1" "554.1" "610.5" "569.9" "610.4" "615.0" "614.2" "610.5" "573.2" "511.1" "" "" "" "" "" "" "" "" "" "" "570.1" "468.8" "386.0" "415.5" "500.1" "477.6" "473.4" "524.9" "447.4" "459.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "42.380" "21" "8" "15" "5" "416" "46.5" "5.29" "48.90" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "" "Apoptotic cleavage of cellular proteins" "1" "3" "0.972" "0.926" "1.000" "1.039" "0.942" "0.991" "1.044" "0.957" "0.980" "1187.8" "1154.1" "1100.4" "1187.5" "1233.8" "1118.5" "1177.4" "1240.6" "1136.3" "1163.7" "" "" "" "" "" "" "" "" "" "" "1187.8" "976.4" "695.8" "865.8" "1010.8" "868.6" "907.6" "1066.7" "887.0" "1046.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "42.353" "21" "6" "16" "6" "313" "34.0" "4.87" "61.86" "6" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.970" "0.948" "0.899" "0.947" "0.985" "0.950" "0.932" "0.944" "0.937" "1102.8" "1070.0" "1045.0" "991.8" "1044.4" "1085.9" "1047.9" "1028.3" "1040.5" "1033.3" "" "" "" "" "" "" "" "" "" "" "1102.8" "905.3" "660.8" "723.1" "855.7" "843.3" "807.8" "884.1" "812.2" "929.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "42.283" "29" "4" "10" "3" "191" "21.3" "8.12" "40.84" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "8" "0" "1.031" "0.860" "1.084" "1.040" "0.973" "1.000" "1.002" "0.948" "0.974" "223.4" "230.4" "192.1" "242.2" "232.4" "217.4" "223.4" "223.9" "211.9" "217.7" "" "" "" "" "" "" "" "" "" "" "223.4" "194.9" "121.5" "176.6" "190.4" "168.9" "172.2" "192.5" "165.4" "195.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "42.231" "23" "10" "19" "10" "390" "43.3" "8.06" "57.29" "10" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "17" "0" "1.102" "1.090" "0.935" "1.112" "1.096" "0.984" "1.115" "1.100" "1.163" "960.9" "1059.1" "1047.2" "898.8" "1068.4" "1053.4" "945.4" "1071.8" "1057.4" "1117.5" "" "" "" "" "" "" "" "" "" "" "960.9" "896.0" "662.1" "655.4" "875.3" "818.0" "728.8" "921.5" "825.4" "1004.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "42.213" "11" "12" "16" "12" "1156" "128.9" "5.10" "41.30" "12" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "Ciliary landscape" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Early Events; tRNA processing in the nucleus; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "36" "0" "0.976" "0.815" "1.030" "1.037" "0.878" "1.130" "1.051" "0.767" "0.924" "955.0" "931.9" "778.4" "983.5" "990.5" "838.9" "1079.0" "1003.9" "732.3" "882.3" "" "" "" "" "" "" "" "" "" "" "955.0" "788.4" "492.2" "717.1" "811.5" "651.4" "831.7" "863.2" "571.6" "793.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "42.206" "37" "6" "18" "6" "219" "23.3" "5.03" "53.40" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Proteasome degradation; Type II interferon signaling" "Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.106" "1.150" "1.065" "1.025" "1.081" "1.015" "1.063" "1.113" "1.107" "481.6" "532.6" "553.9" "513.1" "493.7" "520.8" "488.7" "512.0" "535.9" "533.0" "" "" "" "" "" "" "" "" "" "" "481.6" "450.6" "350.2" "374.1" "404.5" "404.5" "376.7" "440.2" "418.3" "479.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "42.204" "28" "9" "14" "9" "293" "31.3" "10.24" "48.65" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; RMTs methylate histone arginines; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein methylation; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "22" "0" "0.950" "1.078" "0.981" "1.005" "1.122" "1.003" "1.112" "1.097" "1.021" "1426.8" "1355.0" "1538.4" "1400.1" "1434.2" "1600.8" "1430.7" "1586.5" "1565.7" "1457.5" "" "" "" "" "" "" "" "" "" "" "1426.8" "1146.3" "972.7" "1020.9" "1175.1" "1243.1" "1102.9" "1364.1" "1222.1" "1310.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "42.200" "28" "9" "12" "9" "358" "38.8" "5.77" "40.41" "9" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "TAR syndrome" "" "1" "0" "1.026" "1.206" "1.122" "1.044" "1.182" "1.092" "0.961" "1.295" "1.184" "309.3" "317.2" "372.8" "347.1" "322.9" "365.5" "337.6" "297.1" "400.6" "366.2" "" "" "" "" "" "" "" "" "" "" "309.3" "268.4" "235.7" "253.1" "264.6" "283.8" "260.3" "255.4" "312.7" "329.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "42.189" "18" "8" "16" "8" "416" "46.1" "6.52" "49.28" "8" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Complement and coagulation cascades; NRF2 pathway" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "8" "0" "0.749" "0.792" "0.755" "0.763" "1.036" "0.730" "0.653" "1.085" "0.832" "627.4" "469.6" "496.8" "473.9" "478.8" "649.9" "457.9" "409.6" "681.0" "522.2" "" "" "" "" "" "" "" "" "" "" "627.4" "397.3" "314.1" "345.5" "392.3" "504.7" "352.9" "352.2" "531.6" "469.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "42.158" "12" "8" "15" "8" "623" "71.2" "7.37" "42.35" "8" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "VEGFA-VEGFR2 signaling" "NFE2L2 regulating MDR associated enzymes" "2" "0" "1.102" "0.844" "0.985" "1.078" "0.913" "1.025" "1.088" "0.937" "0.958" "893.7" "985.1" "754.7" "880.3" "963.5" "816.3" "916.4" "972.2" "837.8" "855.8" "" "" "" "" "" "" "" "" "" "" "893.7" "833.4" "477.2" "641.8" "789.4" "634.0" "706.4" "835.9" "653.9" "769.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "42.120" "30" "4" "7" "4" "224" "24.3" "4.83" "33.56" "4" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.941" "0.987" "0.928" "1.013" "0.987" "1.087" "0.944" "0.924" "1.011" "608.3" "572.6" "600.6" "564.4" "616.3" "600.5" "661.3" "574.1" "562.4" "615.2" "" "" "" "" "" "" "" "" "" "" "608.3" "484.5" "379.8" "411.5" "505.0" "466.3" "509.8" "493.7" "439.0" "553.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "42.098" "16" "11" "13" "11" "805" "87.7" "4.88" "39.54" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.005" "1.121" "1.150" "1.111" "1.213" "1.263" "1.123" "1.179" "1.043" "187.6" "188.6" "210.2" "215.6" "208.3" "227.5" "236.8" "210.6" "221.1" "195.7" "" "" "" "" "" "" "" "" "" "" "187.6" "159.5" "132.9" "157.2" "170.7" "176.7" "182.6" "181.1" "172.6" "175.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "42.051" "23" "10" "13" "10" "463" "51.8" "5.45" "36.55" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "5" "0" "1.025" "0.924" "1.064" "0.961" "1.004" "0.913" "1.000" "1.089" "1.085" "565.8" "579.7" "522.7" "602.0" "544.0" "568.3" "516.9" "565.6" "616.0" "613.9" "" "" "" "" "" "" "" "" "" "" "565.8" "490.5" "330.5" "439.0" "445.7" "441.3" "398.4" "486.3" "480.8" "551.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "41.898" "44" "7" "35" "7" "149" "17.3" "5.97" "110.30" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "Nuclear signaling by ERBB4" "7" "0" "0.968" "1.108" "1.011" "0.930" "1.041" "1.073" "0.935" "1.058" "0.984" "2279.9" "2206.9" "2525.0" "2304.4" "2120.1" "2374.4" "2447.5" "2132.6" "2413.2" "2242.8" "" "" "" "" "" "" "" "" "" "" "2279.9" "1867.1" "1596.6" "1680.3" "1737.0" "1843.9" "1886.6" "1833.6" "1883.7" "2016.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "41.865" "24" "10" "16" "10" "408" "45.9" "6.18" "52.11" "10" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Thyroxine (thyroid hormone) production" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "4" "0" "0.989" "1.063" "1.037" "1.014" "1.079" "1.026" "1.056" "1.026" "0.987" "663.9" "656.5" "706.0" "688.7" "673.0" "716.0" "681.0" "701.0" "681.4" "655.3" "" "" "" "" "" "" "" "" "" "" "663.9" "555.4" "446.4" "502.1" "551.4" "556.1" "524.9" "602.7" "531.8" "589.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "41.847" "12" "9" "13" "7" "767" "86.4" "6.89" "44.39" "9" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "2" "1.077" "1.002" "1.120" "1.072" "0.983" "1.093" "1.077" "1.035" "1.034" "854.3" "920.5" "856.3" "956.5" "915.5" "839.4" "933.8" "920.5" "884.0" "883.8" "" "" "" "" "" "" "" "" "" "" "854.3" "778.7" "541.5" "697.4" "750.1" "651.9" "719.8" "791.4" "690.0" "794.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6592618097650740774" "False" "High" "IsMasterProtein" "Q9UDY2" "Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2" "0.000" "False" "41.771" "11" "14" "14" "14" "1190" "133.9" "7.40" "37.55" "14" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00595, Pf00625, Pf07653" "9414" "ENSG00000119139" "TJP2" "A2A3H9; B7Z2R8; B7Z7T6; F5H301; F5H886; hsa:9414; Q15883; Q5VXL0; Q5VXL1; Q8N756; Q8NI14; Q99839; Q9UDY0; Q9UDY1; Q9UDY2" "1q21.1 copy number variation syndrome; 15q11q13 copy number variation" "RHOA GTPase cycle; RHOC GTPase cycle; RHOB GTPase cycle; Signaling by Hippo; Apoptotic cleavage of cell adhesion proteins" "7" "0" "0.989" "1.088" "1.036" "1.038" "1.104" "1.077" "1.055" "1.054" "1.062" "709.2" "701.7" "771.6" "735.1" "736.5" "783.0" "763.9" "748.6" "747.8" "753.1" "" "" "" "" "" "" "" "" "" "" "709.2" "593.7" "487.9" "536.0" "603.4" "608.1" "588.9" "643.6" "583.7" "677.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "41.760" "13" "9" "10" "9" "783" "87.3" "9.28" "32.87" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "1.003" "1.513" "1.008" "1.034" "1.513" "1.015" "1.096" "1.440" "1.101" "387.1" "388.3" "585.6" "390.2" "400.1" "585.7" "392.9" "424.4" "557.5" "426.3" "" "" "" "" "" "" "" "" "" "" "387.1" "328.6" "370.3" "284.5" "327.8" "454.8" "302.9" "364.9" "435.2" "383.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483705117675463598" "False" "High" "IsMasterProtein" "P10321" "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" "0.000" "False" "41.758" "16" "5" "15" "1" "366" "40.6" "6.04" "58.07" "5" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3107" "ENSG00000204525" "HLA-C" "hsa:3107; O02863; O02864; O02865; O02866; O02958; O19505; O19652; O19676; O62879; O62882; O62883; O62888; O78060; O78061; O78062; O78063; O78067; O78068; O78069; O78072; O78083; O78090; O78091; O78149; O78165; O78166; O78178; O78202; O78203; O78211; O78214; P04222; P10321; P30499; P30500; P30501; P30502; P30503; P30504; P30505; P30506; P30507; P30508; P30509; P30510; P79498; Q07000; Q29631; Q29641; Q29643; Q29652; Q29743; Q29768; Q29862; Q29864; Q29865; Q29867; Q29921; Q29959; Q29960; Q29963; Q29986; Q29989; Q29990; Q29991; Q29992; Q29993; Q30192; Q31605; Q31627; Q860R1; Q860R2; Q95463; Q95603; Q95604; Q99528; Q9BD28; Q9GIK4; Q9GIK8; Q9GJ33; Q9MY30; Q9MY31; Q9MY35; Q9MY49; Q9MY74; Q9MYI3; Q9TNN7; Q9TNZ8; Q9TPS4; Q9TPV8; Q9TPX2; Q9TQB4; Q9TQJ5; Q9TQP9; Q9UM32; Q9UM33; Q9UM42; Q9UQS9" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "13" "0" "1.075" "1.119" "1.061" "1.066" "1.110" "1.160" "1.144" "0.937" "1.258" "89.3" "96.0" "99.9" "94.7" "95.2" "99.1" "103.6" "102.1" "83.7" "112.4" "" "" "" "" "" "" "" "" "" "" "89.3" "81.2" "63.2" "69.1" "78.0" "77.0" "79.9" "87.8" "65.3" "101.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "41.710" "5" "11" "15" "11" "2357" "251.7" "5.80" "50.67" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "" "COPII-mediated vesicle transport" "1" "0" "1.053" "1.031" "1.091" "1.111" "1.043" "1.163" "1.107" "1.041" "1.060" "557.9" "587.5" "575.0" "608.6" "620.1" "581.9" "649.1" "617.8" "580.8" "591.4" "" "" "" "" "" "" "" "" "" "" "557.9" "497.0" "363.6" "443.8" "508.1" "451.9" "500.3" "531.2" "453.4" "531.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "41.606" "21" "9" "13" "9" "426" "48.3" "6.77" "41.69" "9" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "7" "0" "1.026" "0.784" "0.957" "0.957" "0.769" "0.994" "1.027" "0.778" "0.847" "812.7" "834.0" "637.0" "778.1" "777.9" "624.8" "808.3" "834.4" "632.7" "688.1" "" "" "" "" "" "" "" "" "" "" "812.7" "705.6" "402.8" "567.3" "637.3" "485.2" "623.0" "717.4" "493.8" "618.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528417393103392868" "False" "High" "IsMasterProtein" "Q9BQ04" "RNA-binding protein 4B OS=Homo sapiens OX=9606 GN=RBM4B PE=1 SV=1" "0.000" "False" "41.593" "31" "11" "16" "1" "359" "40.1" "6.74" "44.09" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf00098" "83759" "ENSG00000173914" "RBM4B" "B3KT83; hsa:83759; Q9BQ04" "" "" "0" "0" "1.181" "0.648" "1.416" "1.120" "1.008" "1.010" "1.263" "1.017" "1.446" "11.7" "13.8" "7.6" "16.5" "13.1" "11.7" "11.8" "14.7" "11.8" "16.8" "" "" "" "" "" "" "" "" "" "" "11.7" "11.6" "4.8" "12.0" "10.7" "9.1" "9.1" "12.7" "9.2" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "41.581" "17" "9" "16" "9" "561" "64.3" "6.86" "43.02" "9" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "6" "0" "0.955" "0.892" "0.963" "0.984" "0.923" "0.951" "0.983" "0.894" "0.985" "632.4" "604.2" "564.0" "608.8" "622.2" "583.4" "601.3" "621.5" "565.1" "622.9" "" "" "" "" "" "" "" "" "" "" "632.4" "511.2" "356.6" "443.9" "509.8" "453.1" "463.5" "534.4" "441.1" "560.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "41.556" "26" "6" "12" "6" "258" "27.5" "6.05" "41.88" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate metabolism" "Pentose phosphate pathway" "2" "0" "1.011" "1.030" "1.091" "1.054" "0.965" "1.071" "1.053" "1.020" "1.054" "475.6" "480.9" "489.9" "518.9" "501.2" "459.1" "509.3" "500.6" "485.1" "501.1" "" "" "" "" "" "" "" "" "" "" "475.6" "406.8" "309.8" "378.3" "410.6" "356.5" "392.6" "430.4" "378.7" "450.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "41.498" "28" "6" "24" "6" "239" "26.5" "7.81" "74.68" "6" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.047" "1.141" "1.057" "1.077" "1.126" "1.014" "0.982" "1.093" "1.028" "1224.9" "1282.6" "1398.2" "1294.2" "1319.2" "1379.7" "1242.4" "1203.2" "1339.3" "1259.5" "" "" "" "" "" "" "" "" "" "" "1224.9" "1085.1" "884.1" "943.7" "1080.8" "1071.4" "957.7" "1034.5" "1045.4" "1132.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "41.458" "11" "11" "15" "2" "1341" "147.1" "4.81" "39.09" "11" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "2" "0.910" "0.971" "1.146" "0.981" "0.908" "1.031" "0.902" "1.061" "0.892" "188.4" "171.4" "182.9" "215.8" "184.8" "171.1" "194.2" "169.9" "199.8" "168.1" "" "" "" "" "" "" "" "" "" "" "188.4" "145.0" "115.6" "157.3" "151.4" "132.9" "149.7" "146.1" "155.9" "151.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "41.452" "18" "12" "16" "12" "639" "71.4" "6.40" "48.63" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "Nephrin family interactions" "5" "0" "0.957" "0.989" "1.009" "0.954" "1.010" "0.979" "0.981" "0.959" "0.928" "1169.0" "1118.3" "1156.4" "1180.1" "1115.1" "1180.2" "1144.2" "1146.7" "1121.2" "1085.3" "" "" "" "" "" "" "" "" "" "" "1169.0" "946.1" "731.2" "860.4" "913.6" "916.5" "882.0" "985.9" "875.2" "975.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "41.420" "38" "9" "15" "9" "218" "24.5" "5.94" "48.83" "9" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "0.910" "1.099" "0.864" "0.945" "1.147" "0.962" "0.992" "1.085" "1.081" "814.7" "741.0" "895.4" "704.0" "769.9" "934.4" "783.6" "808.0" "883.7" "880.4" "" "" "" "" "" "" "" "" "" "" "814.7" "626.9" "566.2" "513.3" "630.8" "725.6" "604.0" "694.7" "689.8" "791.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "41.375" "37" "8" "41" "8" "201" "23.0" "5.21" "131.62" "8" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "9" "0" "0.929" "0.915" "0.993" "0.925" "0.936" "1.021" "0.993" "0.879" "0.924" "2571.9" "2390.5" "2353.5" "2553.8" "2377.9" "2406.5" "2625.7" "2555.0" "2260.5" "2377.1" "" "" "" "" "" "" "" "" "" "" "2571.9" "2022.4" "1488.2" "1862.1" "1948.2" "1868.8" "2024.0" "2196.8" "1764.5" "2137.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "41.374" "48" "5" "11" "4" "121" "13.4" "7.24" "40.21" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "" "MASTL Facilitates Mitotic Progression" "1" "2" "0.882" "0.916" "0.890" "0.875" "0.878" "1.049" "0.865" "0.874" "0.827" "1034.4" "912.1" "947.6" "920.3" "905.5" "908.0" "1085.4" "894.5" "903.9" "855.3" "" "" "" "" "" "" "" "" "" "" "1034.4" "771.7" "599.2" "671.0" "741.9" "705.1" "836.7" "769.1" "705.6" "768.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "41.366" "18" "6" "16" "6" "394" "44.7" "6.74" "51.06" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "0.995" "1.048" "1.019" "0.980" "0.968" "0.945" "0.997" "0.976" "0.964" "659.7" "656.2" "691.2" "672.4" "646.5" "638.3" "623.1" "657.5" "643.6" "635.9" "" "" "" "" "" "" "" "" "" "" "659.7" "555.2" "437.0" "490.3" "529.7" "495.7" "480.3" "565.3" "502.4" "571.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "High" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.000" "False" "41.287" "15" "10" "14" "10" "750" "87.3" "6.05" "44.37" "10" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "Growth hormone receptor signaling; PKR-mediated signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of RUNX2 expression and activity; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Downstream signal transduction; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "83" "0" "1.055" "0.820" "1.008" "0.992" "0.830" "0.991" "1.056" "0.781" "0.948" "631.3" "665.8" "517.5" "636.1" "626.4" "523.9" "625.3" "666.6" "493.1" "598.6" "" "" "" "" "" "" "" "" "" "" "631.3" "563.3" "327.2" "463.8" "513.2" "406.8" "482.0" "573.1" "384.9" "538.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "41.260" "15" "8" "17" "4" "521" "58.7" "5.86" "52.45" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "26" "3" "0.988" "1.001" "0.988" "1.020" "1.045" "1.099" "1.053" "0.969" "1.040" "724.2" "715.3" "724.7" "715.8" "739.0" "756.6" "796.0" "762.5" "701.8" "753.3" "" "" "" "" "" "" "" "" "" "" "724.2" "605.1" "458.2" "521.9" "605.5" "587.6" "613.6" "655.6" "547.8" "677.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "41.231" "29" "8" "14" "8" "228" "26.2" "6.44" "48.97" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "0.989" "1.104" "0.995" "1.000" "1.069" "1.049" "0.976" "1.021" "1.040" "733.4" "725.7" "809.6" "729.6" "733.2" "784.3" "769.2" "715.7" "749.0" "762.5" "" "" "" "" "" "" "" "" "" "" "733.4" "614.0" "511.9" "532.0" "600.7" "609.1" "592.9" "615.3" "584.6" "685.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "41.199" "15" "9" "11" "9" "780" "86.1" "5.27" "36.74" "9" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "MET in type 1 papillary renal cell carcinoma" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "8" "0" "0.988" "0.969" "0.976" "1.060" "1.031" "1.082" "1.122" "1.042" "0.997" "458.5" "453.1" "444.3" "447.6" "486.2" "472.5" "496.1" "514.3" "477.7" "457.3" "" "" "" "" "" "" "" "" "" "" "458.5" "383.4" "280.9" "326.4" "398.3" "366.9" "382.4" "442.2" "372.9" "411.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "41.197" "21" "5" "11" "5" "321" "34.0" "6.14" "38.78" "5" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "" "Glycolysis" "1" "0" "1.143" "1.208" "1.261" "1.122" "1.251" "1.182" "1.141" "1.155" "1.271" "274.9" "314.3" "331.9" "346.7" "308.4" "343.7" "324.9" "313.5" "317.4" "349.3" "" "" "" "" "" "" "" "" "" "" "274.9" "265.9" "209.9" "252.8" "252.7" "266.9" "250.5" "269.6" "247.7" "314.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "41.050" "13" "11" "13" "11" "855" "99.9" "6.23" "43.17" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "7" "0" "1.196" "1.084" "1.271" "1.198" "0.981" "1.192" "1.183" "1.071" "1.220" "327.3" "391.5" "354.6" "415.9" "392.1" "321.0" "390.2" "387.0" "350.6" "399.2" "" "" "" "" "" "" "" "" "" "" "327.3" "331.2" "224.2" "303.3" "321.2" "249.3" "300.8" "332.8" "273.7" "358.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "41.039" "21" "13" "19" "5" "583" "68.5" "6.37" "58.25" "13" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "4" "0" "1.051" "1.285" "1.120" "1.127" "1.247" "1.033" "1.034" "1.246" "1.106" "314.6" "330.7" "404.3" "352.3" "354.7" "392.3" "325.0" "325.4" "392.0" "347.9" "" "" "" "" "" "" "" "" "" "" "314.6" "279.7" "255.6" "256.9" "290.6" "304.6" "250.5" "279.8" "306.0" "312.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "40.986" "21" "6" "11" "6" "326" "36.9" "5.97" "41.20" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "Modulators of TCR signaling and T cell activation" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.987" "1.129" "0.986" "1.033" "1.038" "1.067" "1.079" "0.995" "0.975" "865.4" "854.0" "977.3" "853.6" "894.0" "898.6" "923.1" "933.7" "861.3" "843.7" "" "" "" "" "" "" "" "" "" "" "865.4" "722.5" "617.9" "622.4" "732.5" "697.9" "711.5" "802.8" "672.3" "758.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "40.950" "39" "7" "18" "7" "195" "21.6" "6.34" "56.23" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "13" "0" "0.981" "1.063" "0.932" "0.977" "1.002" "0.892" "0.912" "1.066" "1.003" "1043.0" "1023.6" "1109.0" "971.7" "1018.6" "1045.3" "930.8" "950.7" "1111.8" "1045.9" "" "" "" "" "" "" "" "" "" "" "1043.0" "866.0" "701.2" "708.5" "834.6" "811.8" "717.5" "817.4" "867.8" "940.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "40.911" "14" "9" "10" "9" "896" "98.6" "4.64" "32.06" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "8" "0" "0.999" "1.008" "1.105" "0.964" "1.059" "1.043" "1.056" "0.981" "1.046" "413.6" "413.1" "417.1" "456.9" "398.8" "438.0" "431.3" "436.7" "405.9" "432.7" "" "" "" "" "" "" "" "" "" "" "413.6" "349.5" "263.7" "333.2" "326.8" "340.1" "332.4" "375.5" "316.8" "389.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "40.858" "16" "6" "18" "6" "400" "43.4" "7.23" "52.60" "6" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "11" "0" "1.058" "1.054" "1.048" "1.058" "0.990" "1.029" "1.030" "1.036" "1.021" "742.6" "785.6" "782.3" "778.4" "785.6" "735.1" "764.0" "764.7" "769.6" "758.4" "" "" "" "" "" "" "" "" "" "" "742.6" "664.6" "494.7" "567.6" "643.7" "570.8" "588.9" "657.5" "600.7" "681.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "40.819" "19" "7" "13" "7" "468" "50.1" "7.06" "43.86" "7" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "" "Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Early Events; snRNP Assembly; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "0.950" "1.093" "0.969" "1.040" "1.061" "1.081" "1.061" "1.075" "1.098" "897.1" "852.2" "980.8" "869.1" "933.2" "951.8" "969.9" "951.5" "964.2" "984.8" "" "" "" "" "" "" "" "" "" "" "897.1" "721.0" "620.1" "633.7" "764.6" "739.1" "747.7" "818.1" "752.6" "885.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "40.800" "6" "10" "10" "9" "1909" "212.6" "6.83" "35.94" "10" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.038" "0.913" "1.064" "1.145" "0.977" "1.090" "1.033" "0.986" "1.006" "476.0" "494.0" "434.7" "506.3" "545.2" "465.0" "519.0" "491.9" "469.3" "479.0" "" "" "" "" "" "" "" "" "" "" "476.0" "417.9" "274.9" "369.2" "446.7" "361.1" "400.1" "422.9" "366.3" "430.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "40.800" "7" "11" "15" "10" "1438" "162.1" "5.36" "44.25" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "1" "0.997" "1.037" "1.007" "1.004" "1.033" "1.014" "1.005" "0.971" "1.042" "660.3" "658.2" "684.6" "664.8" "662.9" "682.2" "669.9" "663.8" "641.3" "688.2" "" "" "" "" "" "" "" "" "" "" "660.3" "556.8" "432.9" "484.7" "543.1" "529.8" "516.3" "570.7" "500.5" "618.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "40.745" "38" "6" "18" "6" "177" "19.5" "7.71" "57.36" "6" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "0.862" "1.046" "0.861" "0.918" "1.000" "1.025" "0.944" "1.002" "0.925" "823.7" "709.8" "861.8" "709.5" "756.2" "823.5" "844.6" "777.6" "825.2" "761.7" "" "" "" "" "" "" "" "" "" "" "823.7" "600.5" "544.9" "517.3" "619.5" "639.5" "651.0" "668.6" "644.1" "684.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "40.700" "30" "8" "16" "8" "306" "32.7" "5.06" "59.61" "8" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "7" "0" "1.261" "1.347" "1.178" "1.143" "1.455" "1.083" "1.009" "1.493" "1.237" "359.8" "453.6" "484.7" "423.9" "411.1" "523.4" "389.8" "363.1" "537.3" "445.0" "" "" "" "" "" "" "" "" "" "" "359.8" "383.8" "306.5" "309.1" "336.9" "406.5" "300.5" "312.2" "419.4" "400.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "40.696" "18" "8" "9" "8" "650" "72.5" "8.05" "36.94" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "1.135" "0.837" "1.195" "1.185" "0.873" "1.176" "1.124" "0.974" "1.143" "198.7" "225.6" "166.4" "237.6" "235.5" "173.6" "233.8" "223.3" "193.5" "227.2" "" "" "" "" "" "" "" "" "" "" "198.7" "190.9" "105.2" "173.2" "192.9" "134.8" "180.2" "192.0" "151.0" "204.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540404723274759842" "False" "High" "IsMasterProtein" "P52333" "Tyrosine-protein kinase JAK3 OS=Homo sapiens OX=9606 GN=JAK3 PE=1 SV=2" "0.000" "False" "40.629" "9" "10" "14" "9" "1124" "125.0" "7.18" "40.02" "10" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "3718" "ENSG00000105639" "JAK3" "hsa:3718; P52333; Q13259; Q13260; Q13611; Q8N1E8; Q99699; Q9Y6S2" "IL-7 signaling pathway; IL-9 signaling pathway; Oncostatin M signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway" "Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-7 signaling; Signaling by ALK; Interleukin-4 and Interleukin-13 signaling; Interleukin-20 family signaling; Interleukin-2 signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "24" "1" "1.142" "0.820" "1.105" "1.042" "0.789" "1.086" "1.104" "0.838" "0.985" "499.4" "570.2" "409.7" "552.1" "520.2" "394.3" "542.2" "551.6" "418.5" "492.1" "" "" "" "" "" "" "" "" "" "" "499.4" "482.4" "259.1" "402.6" "426.2" "306.2" "418.0" "474.2" "326.7" "442.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "40.614" "28" "8" "17" "2" "323" "37.0" "6.54" "60.12" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "17" "0" "1.023" "1.058" "1.087" "1.004" "1.156" "1.116" "1.017" "1.106" "1.035" "287.2" "293.7" "303.9" "312.2" "288.4" "332.1" "320.5" "292.0" "317.7" "297.2" "" "" "" "" "" "" "" "" "" "" "287.2" "248.5" "192.2" "227.7" "236.3" "257.9" "247.0" "251.1" "248.0" "267.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "40.458" "24" "12" "20" "12" "480" "52.2" "7.24" "59.71" "12" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine biosynthesis" "3" "0" "1.077" "0.969" "1.060" "1.030" "0.934" "1.021" "1.082" "0.934" "1.072" "719.8" "775.6" "697.3" "762.7" "741.7" "672.3" "735.0" "779.0" "672.6" "771.8" "" "" "" "" "" "" "" "" "" "" "719.8" "656.1" "440.9" "556.1" "607.7" "522.1" "566.6" "669.8" "525.0" "693.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "40.436" "26" "7" "15" "7" "248" "27.4" "7.23" "44.91" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "Translation factors; 7q11.23 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "7" "0" "0.984" "0.744" "0.938" "1.009" "0.824" "1.113" "0.991" "0.810" "0.956" "787.0" "774.5" "585.6" "738.6" "793.9" "648.9" "876.2" "779.8" "637.6" "752.3" "" "" "" "" "" "" "" "" "" "" "787.0" "655.2" "370.2" "538.5" "650.4" "503.9" "675.4" "670.5" "497.7" "676.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "40.392" "36" "7" "12" "7" "197" "22.5" "7.99" "40.51" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "3" "0" "1.070" "0.974" "1.021" "1.141" "0.960" "1.022" "1.133" "1.054" "1.058" "216.9" "232.1" "211.3" "221.5" "247.6" "208.2" "221.7" "245.7" "228.5" "229.6" "" "" "" "" "" "" "" "" "" "" "216.9" "196.3" "133.6" "161.5" "202.8" "161.7" "170.9" "211.3" "178.4" "206.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "40.309" "31" "6" "12" "6" "222" "23.8" "8.38" "45.06" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.971" "0.804" "1.038" "1.064" "0.855" "0.956" "1.040" "0.862" "1.025" "566.5" "549.9" "455.3" "588.2" "603.0" "484.6" "541.4" "589.4" "488.4" "580.6" "" "" "" "" "" "" "" "" "" "" "566.5" "465.2" "287.9" "428.9" "494.1" "376.3" "417.3" "506.7" "381.2" "522.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "40.289" "10" "9" "13" "9" "974" "110.4" "6.49" "44.93" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.019" "0.883" "0.946" "1.020" "0.912" "1.109" "1.140" "0.917" "1.030" "739.8" "753.7" "653.4" "699.6" "754.9" "674.7" "820.2" "843.2" "678.6" "761.6" "" "" "" "" "" "" "" "" "" "" "739.8" "637.7" "413.1" "510.1" "618.5" "523.9" "632.3" "725.0" "529.7" "684.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2475503787040523239" "False" "High" "IsMasterProtein" "Q9UM54" "Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4" "0.000" "False" "40.209" "9" "10" "12" "10" "1294" "149.6" "8.53" "38.48" "10" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf16521, Pf21521" "4646" "ENSG00000196586" "MYO6" "A6H8V4; E1P540; hsa:4646; Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; Q9UM54" "VEGFA-VEGFR2 signaling; Joubert syndrome" "RHOU GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Trafficking of AMPA receptors; Gap junction degradation" "7" "0" "1.086" "1.072" "1.154" "1.128" "1.088" "1.084" "1.069" "1.153" "1.159" "431.7" "468.9" "462.6" "498.0" "487.1" "469.5" "467.8" "461.2" "497.6" "500.3" "" "" "" "" "" "" "" "" "" "" "431.7" "396.7" "292.5" "363.1" "399.0" "364.6" "360.6" "396.6" "388.4" "449.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "40.119" "22" "7" "11" "4" "318" "34.7" "6.61" "38.52" "7" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "0" "1.067" "1.068" "0.943" "0.950" "1.008" "0.984" "0.988" "1.055" "1.012" "513.2" "547.8" "548.0" "484.0" "487.6" "517.1" "505.1" "507.3" "541.3" "519.4" "" "" "" "" "" "" "" "" "" "" "513.2" "463.4" "346.5" "352.9" "399.5" "401.6" "389.3" "436.2" "422.5" "467.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "40.104" "18" "9" "12" "8" "517" "57.2" "6.99" "43.66" "9" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "" "Mitochondrial protein degradation; Ethanol oxidation" "2" "1" "1.004" "1.022" "0.943" "1.000" "1.015" "0.912" "0.949" "1.018" "1.033" "1033.7" "1038.1" "1056.5" "975.0" "1033.6" "1048.8" "942.5" "981.3" "1052.4" "1067.6" "" "" "" "" "" "" "" "" "" "" "1033.7" "878.3" "668.0" "710.9" "846.9" "814.5" "726.5" "843.7" "821.4" "959.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "40.083" "30" "5" "16" "5" "182" "21.5" "6.60" "59.31" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Transcriptional regulation of granulopoiesis; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "27" "0" "1.037" "0.881" "1.092" "1.041" "0.921" "1.124" "1.108" "0.916" "1.022" "782.4" "811.1" "689.2" "854.1" "814.6" "720.9" "879.3" "867.1" "716.4" "799.6" "" "" "" "" "" "" "" "" "" "" "782.4" "686.2" "435.8" "622.8" "667.4" "559.8" "677.8" "745.5" "559.2" "718.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552754402547085825" "False" "High" "IsMasterProtein" "Q5MIZ7" "Serine/threonine-protein phosphatase 4 regulatory subunit 3B OS=Homo sapiens OX=9606 GN=PPP4R3B PE=1 SV=2" "0.000" "False" "40.073" "9" "6" "10" "2" "849" "97.4" "4.96" "30.68" "6" "other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "57223" "ENSG00000275052" "PPP4R3B" "hsa:57223; Q5MIZ7; Q6P9B0; Q86XB8; Q9BQJ0; Q9BRK2; Q9H913; Q9P2G0" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.056" "1.320" "1.217" "1.009" "1.288" "1.074" "1.173" "1.012" "1.150" "39.3" "41.4" "51.8" "47.8" "39.6" "50.5" "42.2" "46.0" "39.7" "45.1" "" "" "" "" "" "" "" "" "" "" "39.3" "35.1" "32.8" "34.8" "32.5" "39.3" "32.5" "39.6" "31.0" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "39.984" "18" "10" "10" "10" "594" "67.2" "5.96" "35.45" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "1.089" "1.086" "1.059" "1.077" "1.120" "1.087" "1.087" "1.058" "1.097" "420.0" "457.4" "456.3" "445.0" "452.4" "470.4" "456.7" "456.6" "444.2" "460.7" "" "" "" "" "" "" "" "" "" "" "420.0" "387.0" "288.5" "324.4" "370.6" "365.3" "352.0" "392.6" "346.7" "414.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "39.950" "17" "8" "13" "8" "437" "51.5" "9.94" "37.72" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.969" "1.184" "0.952" "0.977" "1.145" "0.985" "0.994" "1.077" "0.972" "821.8" "796.4" "973.1" "782.5" "802.5" "940.9" "809.4" "816.8" "884.8" "798.6" "" "" "" "" "" "" "" "" "" "" "821.8" "673.8" "615.3" "570.5" "657.5" "730.7" "623.9" "702.3" "690.6" "718.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5626917880360896955" "False" "High" "IsMasterProtein" "Q8N201" "Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2" "0.000" "False" "39.945" "5" "10" "13" "10" "2190" "244.1" "6.13" "40.52" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus" "" "Pf12432" "26173" "ENSG00000164880" "INTS1" "A6NJ44; hsa:26173; Q6NT70; Q6UX74; Q8N201; Q8WV40; Q96D36; Q9NTD1; Q9P2A8; Q9Y3W8" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.077" "0.882" "1.042" "1.049" "0.886" "0.960" "0.998" "0.963" "0.984" "780.4" "840.7" "688.6" "813.4" "818.4" "691.3" "749.5" "778.6" "751.4" "767.6" "" "" "" "" "" "" "" "" "" "" "780.4" "711.2" "435.4" "593.1" "670.5" "536.9" "577.7" "669.5" "586.6" "690.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "39.896" "16" "8" "10" "8" "669" "72.4" "8.34" "31.57" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "0.930" "0.867" "1.085" "1.048" "0.989" "1.032" "0.971" "0.899" "1.038" "295.9" "275.1" "256.6" "321.0" "310.2" "292.7" "305.5" "287.4" "266.1" "307.3" "" "" "" "" "" "" "" "" "" "" "295.9" "232.7" "162.2" "234.1" "254.1" "227.3" "235.5" "247.1" "207.7" "276.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "39.751" "12" "10" "12" "10" "706" "79.9" "6.68" "39.23" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.084" "0.857" "1.087" "1.083" "0.917" "1.058" "1.046" "0.899" "1.010" "768.0" "832.8" "658.0" "834.7" "831.4" "704.2" "812.7" "803.2" "690.5" "775.8" "" "" "" "" "" "" "" "" "" "" "768.0" "704.6" "416.1" "608.6" "681.2" "546.9" "626.5" "690.6" "539.0" "697.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "39.686" "12" "9" "10" "9" "778" "88.0" "6.80" "34.75" "9" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "0.993" "0.980" "0.985" "0.926" "0.970" "1.046" "1.024" "0.943" "0.998" "569.2" "565.3" "557.8" "560.5" "527.2" "552.0" "595.5" "583.1" "537.0" "567.9" "" "" "" "" "" "" "" "" "" "" "569.2" "478.2" "352.7" "408.7" "431.9" "428.7" "459.0" "501.4" "419.1" "510.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "39.657" "35" "6" "13" "6" "199" "21.5" "5.24" "39.46" "6" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "0.928" "0.928" "1.005" "0.984" "0.989" "1.095" "1.002" "1.001" "0.995" "652.4" "605.6" "605.4" "655.6" "642.1" "645.5" "714.5" "653.4" "653.1" "649.0" "" "" "" "" "" "" "" "" "" "" "652.4" "512.3" "382.8" "478.0" "526.1" "501.3" "550.8" "561.8" "509.8" "583.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "39.651" "12" "12" "12" "12" "1058" "120.0" "6.04" "40.12" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "1.113" "0.859" "0.989" "1.036" "0.843" "1.115" "1.043" "0.789" "0.952" "372.4" "414.5" "320.0" "368.4" "385.8" "313.8" "415.3" "388.6" "294.0" "354.7" "" "" "" "" "" "" "" "" "" "" "372.4" "350.6" "202.4" "268.6" "316.1" "243.7" "320.1" "334.1" "229.5" "318.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "39.644" "37" "6" "17" "6" "160" "18.7" "4.54" "50.71" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "12" "0" "1.027" "0.865" "0.964" "0.939" "0.844" "0.951" "0.980" "0.845" "0.891" "859.5" "882.4" "743.1" "828.5" "807.4" "725.5" "817.7" "842.2" "726.1" "765.4" "" "" "" "" "" "" "" "" "" "" "859.5" "746.5" "469.9" "604.1" "661.5" "563.4" "630.3" "724.1" "566.8" "688.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "39.599" "9" "8" "13" "8" "1074" "116.9" "9.04" "47.70" "8" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "Exercise-induced circadian regulation" "" "1" "0" "0.955" "0.953" "1.009" "1.028" "0.994" "0.997" "1.039" "0.946" "0.996" "664.8" "635.1" "633.7" "670.9" "683.6" "660.6" "662.6" "690.9" "628.7" "662.2" "" "" "" "" "" "" "" "" "" "" "664.8" "537.3" "400.7" "489.2" "560.1" "513.0" "510.8" "594.1" "490.7" "595.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3548704678811192106" "False" "High" "IsMasterProtein" "Q8ND30" "Liprin-beta-2 OS=Homo sapiens OX=9606 GN=PPFIBP2 PE=1 SV=3" "0.000" "False" "39.514" "14" "11" "13" "11" "876" "98.5" "6.27" "41.10" "11" "cell organization and biogenesis" "cytosol;other cell component" "other molecular function" "Pf00536, Pf07647" "8495" "ENSG00000166387" "PPFIBP2" "B7Z433; E9PK77; hsa:8495; O75337; Q8ND30; Q8WW26" "Ectoderm differentiation" "Receptor-type tyrosine-protein phosphatases" "2" "0" "0.966" "0.901" "1.081" "0.976" "0.931" "0.978" "1.002" "0.937" "0.956" "315.0" "304.4" "283.9" "340.4" "307.3" "293.1" "307.9" "315.6" "295.2" "301.0" "" "" "" "" "" "" "" "" "" "" "315.0" "257.5" "179.5" "248.2" "251.8" "227.6" "237.4" "271.4" "230.4" "270.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3240734639385883819" "False" "High" "IsMasterProtein" "P53004" "Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2" "0.000" "False" "39.500" "24" "7" "12" "7" "296" "33.4" "6.44" "38.16" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf01408, Pf09166" "644" "ENSG00000106605" "BLVRA" "A8K747; hsa:644; O95019; P53004; Q86UX0; Q96QL4; Q9BRW8" "IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "3" "0" "0.959" "0.924" "0.965" "0.959" "0.936" "0.937" "0.939" "0.944" "1.035" "890.8" "854.2" "823.5" "859.9" "854.3" "833.9" "834.9" "836.6" "840.6" "921.6" "" "" "" "" "" "" "" "" "" "" "890.8" "722.7" "520.7" "627.0" "699.9" "647.6" "643.6" "719.3" "656.2" "828.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "39.434" "23" "11" "19" "8" "444" "49.3" "7.23" "49.84" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "3" "0.944" "0.850" "0.951" "0.967" "0.838" "0.962" "0.981" "0.821" "0.898" "1234.2" "1164.6" "1049.7" "1173.7" "1193.4" "1033.9" "1187.0" "1210.7" "1013.8" "1108.0" "" "" "" "" "" "" "" "" "" "" "1234.2" "985.3" "663.7" "855.8" "977.7" "802.9" "915.0" "1041.0" "791.3" "996.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "39.411" "17" "8" "18" "8" "551" "59.2" "7.15" "50.48" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.075" "1.012" "1.003" "1.077" "0.938" "1.094" "1.010" "1.052" "0.998" "342.6" "368.2" "346.8" "343.7" "368.9" "321.3" "374.8" "346.1" "360.5" "341.9" "" "" "" "" "" "" "" "" "" "" "342.6" "311.5" "219.3" "250.6" "302.3" "249.5" "288.9" "297.5" "281.4" "307.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "High" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.000" "False" "39.402" "7" "9" "12" "9" "1232" "139.8" "6.27" "35.52" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Retinoblastoma gene in cancer" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "5" "0" "1.067" "0.833" "1.040" "1.054" "0.916" "1.077" "1.032" "0.869" "0.931" "541.1" "577.6" "450.8" "562.7" "570.4" "495.5" "582.5" "558.2" "470.2" "503.5" "" "" "" "" "" "" "" "" "" "" "541.1" "488.7" "285.1" "410.3" "467.3" "384.8" "449.0" "480.0" "367.1" "452.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "39.372" "8" "13" "15" "8" "1585" "176.5" "5.38" "39.70" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "ISG15 antiviral mechanism" "3" "0" "0.996" "0.959" "1.063" "1.124" "1.042" "1.046" "1.054" "0.935" "0.977" "555.3" "553.3" "532.7" "590.1" "624.5" "578.4" "581.1" "585.1" "519.2" "542.4" "" "" "" "" "" "" "" "" "" "" "555.3" "468.1" "336.8" "430.3" "511.6" "449.2" "447.9" "503.1" "405.3" "487.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "39.314" "15" "7" "11" "7" "530" "59.3" "10.10" "32.76" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "VEGFA-VEGFR2 signaling; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.082" "1.012" "1.023" "1.015" "1.021" "1.135" "1.068" "0.955" "0.981" "654.0" "707.8" "661.8" "668.9" "663.8" "667.4" "742.5" "698.5" "624.4" "641.7" "" "" "" "" "" "" "" "" "" "" "654.0" "598.8" "418.5" "487.7" "543.8" "518.3" "572.3" "600.6" "487.4" "576.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "39.281" "7" "7" "13" "7" "1119" "117.0" "7.34" "45.27" "7" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "1.016" "0.965" "1.008" "1.029" "1.071" "1.017" "0.997" "1.005" "1.021" "753.5" "765.7" "726.9" "759.9" "775.0" "806.7" "766.0" "751.6" "757.3" "769.3" "" "" "" "" "" "" "" "" "" "" "753.5" "647.8" "459.6" "554.1" "635.0" "626.5" "590.5" "646.2" "591.1" "691.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "39.258" "12" "8" "11" "8" "802" "85.1" "6.79" "35.65" "8" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "1.015" "0.907" "1.006" "0.954" "0.966" "0.999" "0.959" "0.984" "1.019" "445.6" "452.1" "404.0" "448.4" "424.9" "430.4" "445.0" "427.3" "438.7" "454.2" "" "" "" "" "" "" "" "" "" "" "445.6" "382.5" "255.5" "327.0" "348.1" "334.2" "343.0" "367.4" "342.4" "408.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "39.220" "20" "7" "9" "7" "389" "43.8" "6.92" "31.78" "7" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "1.031" "1.035" "0.994" "1.030" "1.044" "0.996" "1.047" "1.033" "1.046" "769.6" "793.7" "796.4" "764.8" "792.9" "803.7" "766.3" "805.5" "794.9" "805.2" "" "" "" "" "" "" "" "" "" "" "769.6" "671.5" "503.6" "557.6" "649.6" "624.1" "590.7" "692.6" "620.4" "724.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "39.166" "28" "4" "10" "3" "183" "20.8" "5.33" "38.12" "4" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "6" "0" "1.019" "1.087" "0.922" "1.026" "1.032" "1.047" "0.993" "1.064" "0.954" "798.6" "813.5" "868.4" "736.7" "819.0" "823.9" "835.8" "792.7" "850.0" "762.0" "" "" "" "" "" "" "" "" "" "" "798.6" "688.3" "549.1" "537.2" "671.0" "639.8" "644.3" "681.5" "663.5" "685.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "39.141" "23" "6" "21" "5" "268" "30.0" "5.14" "68.77" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "16" "1" "0.979" "1.060" "0.977" "0.991" "1.009" "1.041" "1.020" "0.974" "1.006" "867.1" "848.9" "919.4" "846.8" "859.2" "874.7" "902.7" "884.0" "844.9" "872.3" "" "" "" "" "" "" "" "" "" "" "867.1" "718.2" "581.4" "617.4" "703.9" "679.3" "695.8" "760.1" "659.5" "784.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "39.114" "16" "12" "12" "12" "756" "84.5" "5.72" "32.82" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "12" "0" "0.987" "0.806" "1.026" "1.032" "0.813" "1.104" "1.028" "0.792" "0.914" "604.8" "597.0" "487.7" "620.5" "624.0" "491.5" "667.6" "621.5" "479.0" "552.8" "" "" "" "" "" "" "" "" "" "" "604.8" "505.1" "308.4" "452.4" "511.2" "381.7" "514.6" "534.4" "373.9" "497.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "39.107" "9" "10" "11" "10" "1124" "124.1" "8.07" "37.35" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "Retinoblastoma gene in cancer; Nephrotic syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "5" "0" "1.080" "0.817" "1.102" "0.971" "0.758" "1.045" "1.092" "0.810" "0.927" "220.2" "237.8" "179.8" "242.6" "213.9" "166.9" "230.0" "240.5" "178.4" "204.1" "" "" "" "" "" "" "" "" "" "" "220.2" "201.2" "113.7" "176.9" "175.2" "129.6" "177.3" "206.8" "139.3" "183.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "39.088" "14" "9" "12" "8" "649" "73.4" "7.88" "35.23" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "Progeria-associated lipodystrophy" "" "1" "0" "1.078" "0.989" "0.978" "1.057" "1.009" "0.987" "1.041" "0.946" "1.031" "624.3" "672.7" "617.2" "610.3" "659.6" "630.2" "616.3" "649.7" "590.4" "643.9" "" "" "" "" "" "" "" "" "" "" "624.3" "569.2" "390.2" "445.0" "540.4" "489.4" "475.1" "558.7" "460.8" "578.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "38.991" "31" "9" "18" "2" "330" "37.5" "6.33" "59.97" "9" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "15" "7" "0.984" "1.045" "0.936" "0.947" "1.142" "1.055" "1.045" "1.038" "1.089" "996.7" "980.8" "1041.6" "933.1" "944.1" "1138.6" "1051.2" "1041.9" "1034.8" "1085.0" "" "" "" "" "" "" "" "" "" "" "996.7" "829.8" "658.6" "680.4" "773.5" "884.2" "810.3" "895.8" "807.7" "975.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "38.922" "18" "6" "10" "6" "369" "40.9" "7.44" "37.43" "6" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "0" "1.057" "1.045" "1.094" "1.123" "0.973" "1.090" "1.135" "1.021" "0.997" "340.4" "359.8" "355.6" "372.3" "382.3" "331.2" "371.1" "386.3" "347.7" "339.4" "" "" "" "" "" "" "" "" "" "" "340.4" "304.4" "224.9" "271.4" "313.2" "257.2" "286.0" "332.1" "271.4" "305.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965361047709710571" "False" "High" "IsMasterProtein" "Q58FG1" "Putative heat shock protein HSP 90-alpha A4 OS=Homo sapiens OX=9606 GN=HSP90AA4P PE=5 SV=1" "0.000" "False" "38.909" "10" "4" "48" "1" "418" "47.7" "5.19" "154.86" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00183, Pf13589" "" "" "HSP90AA4P" "Q58FG1" "" "" "0" "0" "1.160" "1.248" "1.363" "1.214" "1.250" "1.077" "1.310" "1.362" "1.337" "103.2" "119.6" "128.8" "140.6" "125.2" "129.0" "111.1" "135.2" "140.6" "137.9" "" "" "" "" "" "" "" "" "" "" "103.2" "101.2" "81.4" "102.5" "102.6" "100.2" "85.7" "116.2" "109.7" "124.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "38.903" "18" "6" "12" "6" "408" "44.9" "8.65" "41.26" "6" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "1" "0" "0.921" "1.699" "1.075" "1.230" "2.054" "1.324" "1.337" "1.889" "1.265" "653.5" "601.9" "1110.4" "702.4" "804.1" "1342.2" "865.3" "873.7" "1234.5" "826.9" "" "" "" "" "" "" "" "" "" "" "653.5" "509.2" "702.1" "512.1" "658.8" "1042.4" "667.0" "751.2" "963.6" "743.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "38.902" "31" "9" "15" "9" "305" "33.7" "7.33" "44.62" "9" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Translation factors" "Recycling of eIF2:GDP" "2" "0" "0.987" "0.941" "0.977" "0.939" "0.874" "0.874" "0.926" "0.902" "0.906" "388.8" "383.6" "365.7" "379.9" "365.1" "339.6" "339.6" "359.9" "350.7" "352.1" "" "" "" "" "" "" "" "" "" "" "388.8" "324.5" "231.3" "277.0" "299.1" "263.7" "261.8" "309.5" "273.8" "316.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "38.896" "15" "7" "10" "4" "521" "57.8" "4.94" "37.31" "7" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "3" "0.962" "0.896" "0.943" "0.949" "0.913" "0.985" "1.047" "0.837" "0.940" "698.5" "671.6" "626.0" "658.7" "662.7" "637.4" "688.0" "731.5" "584.5" "656.3" "" "" "" "" "" "" "" "" "" "" "698.5" "568.2" "395.8" "480.3" "542.9" "495.0" "530.4" "628.9" "456.3" "590.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "38.870" "13" "12" "15" "12" "822" "91.3" "6.80" "50.19" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "0.991" "1.072" "0.994" "0.989" "1.016" "1.069" "1.012" "0.972" "0.952" "572.6" "567.5" "614.1" "569.1" "566.3" "581.7" "612.0" "579.7" "556.6" "545.1" "" "" "" "" "" "" "" "" "" "" "572.6" "480.1" "388.3" "414.9" "464.0" "451.8" "471.8" "498.4" "434.5" "490.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "38.846" "16" "12" "13" "11" "718" "83.1" "5.17" "41.52" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "1.093" "0.994" "1.088" "1.118" "0.968" "1.146" "1.164" "1.006" "1.125" "372.3" "406.8" "369.9" "405.1" "416.3" "360.5" "426.8" "433.5" "374.6" "419.1" "" "" "" "" "" "" "" "" "" "" "372.3" "344.2" "233.9" "295.4" "341.0" "280.0" "329.0" "372.7" "292.4" "376.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "38.807" "5" "12" "12" "11" "2440" "270.0" "7.11" "35.85" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "30" "1" "1.039" "0.941" "1.129" "1.076" "1.012" "1.156" "1.069" "0.938" "1.046" "639.8" "664.5" "602.1" "722.0" "688.3" "647.5" "739.9" "684.2" "599.9" "669.3" "" "" "" "" "" "" "" "" "" "" "639.8" "562.2" "380.7" "526.5" "563.9" "502.9" "570.4" "588.2" "468.3" "601.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "38.740" "10" "10" "12" "10" "1153" "130.1" "8.48" "39.57" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "0.979" "0.885" "0.930" "0.959" "1.001" "1.036" "0.968" "0.883" "0.948" "769.6" "753.7" "681.1" "715.7" "738.2" "770.6" "797.0" "745.3" "679.9" "729.6" "" "" "" "" "" "" "" "" "" "" "769.6" "637.6" "430.7" "521.8" "604.8" "598.4" "614.3" "640.8" "530.7" "655.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "38.727" "52" "4" "53" "4" "105" "11.7" "4.92" "180.41" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "20" "0" "0.937" "1.031" "0.976" "1.002" "1.043" "1.142" "0.972" "1.030" "1.034" "3627.4" "3398.4" "3740.8" "3539.1" "3635.7" "3784.6" "4143.7" "3526.3" "3737.4" "3750.5" "" "" "" "" "" "" "" "" "" "" "3627.4" "2875.1" "2365.4" "2580.5" "2978.8" "2939.0" "3194.1" "3031.9" "2917.3" "3371.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "38.677" "8" "8" "9" "8" "1250" "141.0" "5.31" "32.25" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.956" "0.673" "0.985" "0.974" "0.811" "0.961" "1.015" "0.782" "0.985" "523.6" "500.7" "352.5" "515.9" "509.8" "424.5" "503.2" "531.6" "409.5" "516.0" "" "" "" "" "" "" "" "" "" "" "523.6" "423.6" "222.9" "376.2" "417.7" "329.6" "387.9" "457.1" "319.7" "463.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "38.665" "10" "4" "13" "4" "656" "68.4" "9.33" "51.86" "4" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.957" "1.059" "0.974" "1.022" "1.042" "1.120" "0.963" "0.973" "0.966" "742.4" "710.8" "785.9" "723.1" "758.6" "773.5" "831.6" "714.8" "722.2" "717.0" "" "" "" "" "" "" "" "" "" "" "742.4" "601.3" "496.9" "527.2" "621.5" "600.7" "641.1" "614.6" "563.7" "644.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "38.649" "16" "9" "12" "9" "567" "65.0" "5.67" "37.14" "9" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.009" "1.102" "1.043" "1.037" "1.021" "0.945" "1.013" "1.075" "1.052" "817.6" "824.6" "901.2" "853.0" "847.6" "834.4" "772.7" "828.4" "878.5" "859.9" "" "" "" "" "" "" "" "" "" "" "817.6" "697.6" "569.8" "622.0" "694.4" "648.0" "595.6" "712.3" "685.7" "773.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "38.620" "37" "7" "15" "7" "192" "22.0" "5.73" "53.30" "7" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.045" "0.857" "1.041" "1.048" "0.855" "1.059" "1.067" "0.803" "0.944" "913.5" "954.2" "782.6" "951.3" "957.7" "780.9" "967.4" "974.7" "733.3" "862.6" "" "" "" "" "" "" "" "" "" "" "913.5" "807.3" "494.8" "693.7" "784.6" "606.5" "745.7" "838.1" "572.4" "775.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6134268530089920080" "False" "High" "IsMasterProtein" "P09668" "Pro-cathepsin H OS=Homo sapiens OX=9606 GN=CTSH PE=1 SV=4" "0.000" "False" "38.611" "20" "6" "13" "6" "335" "37.4" "8.07" "43.14" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1512" "ENSG00000103811" "CTSH" "B2RBK0; hsa:1512; P09668; Q96NY6; Q9BUM7" "" "MHC class II antigen presentation; Neutrophil degranulation; Surfactant metabolism" "3" "0" "0.902" "1.194" "0.940" "0.961" "1.102" "0.929" "0.931" "0.978" "0.947" "699.9" "631.0" "835.4" "658.1" "672.8" "771.6" "650.2" "651.7" "684.4" "662.5" "" "" "" "" "" "" "" "" "" "" "699.9" "533.8" "528.2" "479.8" "551.3" "599.2" "501.2" "560.4" "534.2" "595.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "38.587" "8" "9" "10" "9" "1151" "130.1" "5.05" "31.59" "9" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "eIF5A regulation in response to inhibition of the nuclear export system" "" "1" "0" "1.109" "1.072" "0.983" "1.004" "0.959" "1.058" "1.078" "1.004" "1.028" "299.4" "332.0" "320.9" "294.4" "300.5" "287.0" "316.7" "322.8" "300.7" "307.8" "" "" "" "" "" "" "" "" "" "" "299.4" "280.9" "202.9" "214.6" "246.2" "222.9" "244.1" "277.5" "234.7" "276.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "38.521" "31" "7" "8" "7" "272" "28.2" "6.28" "32.29" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.007" "1.018" "1.055" "1.064" "1.058" "0.980" "1.008" "1.059" "1.007" "387.1" "389.9" "394.2" "408.3" "412.1" "409.6" "379.3" "390.1" "410.2" "389.8" "" "" "" "" "" "" "" "" "" "" "387.1" "329.9" "249.3" "297.7" "337.6" "318.1" "292.3" "335.4" "320.2" "350.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "38.503" "12" "8" "11" "8" "746" "83.6" "6.19" "35.42" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.053" "1.122" "1.181" "1.072" "1.129" "1.088" "1.068" "1.035" "0.953" "365.2" "384.4" "409.6" "431.3" "391.4" "412.2" "397.4" "390.0" "377.9" "347.9" "" "" "" "" "" "" "" "" "" "" "365.2" "325.2" "259.0" "314.5" "320.7" "320.1" "306.3" "335.3" "295.0" "312.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "38.491" "16" "5" "11" "5" "376" "42.5" "6.84" "34.96" "5" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.007" "1.033" "0.983" "1.025" "1.018" "1.022" "0.978" "1.033" "1.119" "249.1" "250.7" "257.4" "244.8" "255.4" "253.6" "254.6" "243.7" "257.2" "278.6" "" "" "" "" "" "" "" "" "" "" "249.1" "212.1" "162.8" "178.5" "209.2" "196.9" "196.3" "209.5" "200.8" "250.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254459010250463691" "False" "High" "IsMasterProtein" "Cont_Q3ZBD7" "Glucose-6-phosphate isomerase OS=Bos taurus OX=9913 GN=GPI PE=2 SV=4" "0.000" "True" "38.485" "11" "4" "11" "1" "557" "62.8" "7.71" "41.42" "4" "other metabolic processes;signal transduction" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "104995211; 109572099; 280808" "ENSBTAG00000006396" "GPI" "A0A6B0R509; A0A6P3HXC3; A0A6P5DB13; biu:109572099; bta:280808; F1MD19; O46595; Q3ZBD7" "Glycolysis and gluconeogenesis; Cori cycle" "TP53 Regulates Metabolic Genes; Neutrophil degranulation; Gluconeogenesis; Glycolysis" "6" "0" "0.860" "0.984" "1.014" "0.937" "1.167" "0.929" "0.938" "0.960" "0.833" "131.7" "113.2" "129.6" "133.5" "123.4" "153.7" "122.3" "123.6" "126.4" "109.7" "" "" "" "" "" "" "" "" "" "" "131.7" "95.8" "81.9" "97.4" "101.1" "119.3" "94.3" "106.3" "98.7" "98.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "38.440" "14" "6" "13" "6" "517" "58.2" "7.49" "49.63" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "32" "0" "1.143" "1.053" "1.077" "1.067" "1.110" "1.087" "1.113" "1.037" "1.043" "1014.7" "1159.8" "1068.3" "1093.0" "1082.3" "1126.6" "1102.8" "1129.2" "1052.1" "1058.2" "" "" "" "" "" "" "" "" "" "" "1014.7" "981.2" "675.5" "797.0" "886.7" "874.9" "850.1" "970.9" "821.2" "951.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "38.419" "20" "8" "15" "8" "439" "50.4" "6.29" "50.77" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "13" "0" "1.023" "1.008" "1.014" "1.006" "0.988" "1.042" "1.039" "0.954" "0.964" "915.0" "936.4" "922.3" "927.4" "920.7" "904.0" "953.9" "950.5" "873.3" "882.2" "" "" "" "" "" "" "" "" "" "" "915.0" "792.2" "583.2" "676.2" "754.4" "702.0" "735.3" "817.3" "681.7" "793.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "38.403" "20" "7" "13" "7" "451" "51.1" "6.14" "40.91" "7" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.089" "0.889" "1.040" "1.104" "0.928" "1.110" "1.071" "0.884" "0.976" "614.1" "668.8" "545.9" "638.6" "677.9" "570.2" "681.8" "657.6" "543.0" "599.4" "" "" "" "" "" "" "" "" "" "" "614.1" "565.9" "345.2" "465.7" "555.4" "442.8" "525.6" "565.4" "423.9" "538.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "38.401" "19" "5" "8" "4" "347" "35.9" "9.22" "36.03" "5" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "1.114" "0.984" "1.088" "1.022" "1.044" "1.163" "0.974" "0.981" "0.979" "446.5" "497.3" "439.4" "485.7" "456.5" "466.0" "519.1" "435.0" "438.1" "437.4" "" "" "" "" "" "" "" "" "" "" "446.5" "420.8" "277.8" "354.1" "374.0" "361.9" "400.2" "374.0" "342.0" "393.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "38.398" "17" "9" "21" "8" "589" "64.1" "8.22" "60.06" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.029" "1.066" "0.982" "1.057" "1.078" "0.965" "1.018" "1.068" "1.026" "1216.7" "1251.4" "1296.4" "1195.1" "1285.5" "1311.2" "1174.4" "1238.9" "1299.9" "1248.9" "" "" "" "" "" "" "" "" "" "" "1216.7" "1058.7" "819.7" "871.4" "1053.2" "1018.3" "905.3" "1065.2" "1014.7" "1122.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "38.381" "11" "8" "9" "8" "782" "88.4" "5.11" "29.71" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "0.953" "0.933" "1.034" "1.020" "1.040" "1.067" "1.032" "1.016" "0.963" "325.7" "310.5" "303.7" "336.6" "332.3" "338.8" "347.6" "336.2" "331.0" "313.7" "" "" "" "" "" "" "" "" "" "" "325.7" "262.7" "192.0" "245.4" "272.2" "263.1" "267.9" "289.0" "258.3" "282.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "38.370" "18" "8" "11" "8" "522" "58.4" "7.42" "40.14" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.037" "1.032" "1.056" "1.048" "1.044" "1.059" "1.055" "1.051" "1.140" "646.2" "669.9" "666.8" "682.4" "677.0" "674.9" "684.4" "681.8" "679.1" "736.4" "" "" "" "" "" "" "" "" "" "" "646.2" "566.8" "421.6" "497.6" "554.7" "524.1" "527.6" "586.2" "530.1" "662.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "38.340" "14" "9" "12" "9" "665" "75.7" "6.84" "39.07" "9" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "0.962" "0.959" "0.923" "0.968" "0.974" "0.967" "1.033" "0.916" "0.991" "900.3" "865.9" "863.6" "830.9" "871.9" "876.5" "870.5" "929.7" "824.5" "892.6" "" "" "" "" "" "" "" "" "" "" "900.3" "732.6" "546.1" "605.8" "714.3" "680.7" "671.0" "799.3" "643.6" "802.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "High" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.000" "False" "38.289" "22" "7" "10" "7" "425" "46.6" "5.67" "36.81" "7" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.137" "1.071" "1.125" "1.068" "1.040" "1.163" "1.161" "1.189" "1.067" "279.3" "317.6" "299.0" "314.1" "298.2" "290.5" "324.9" "324.3" "332.1" "298.1" "" "" "" "" "" "" "" "" "" "" "279.3" "268.7" "189.1" "229.0" "244.3" "225.6" "250.4" "278.8" "259.2" "268.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "38.280" "28" "8" "17" "2" "327" "37.2" "6.19" "58.14" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "19" "0" "1.059" "1.126" "1.080" "1.054" "1.171" "1.164" "1.161" "1.157" "1.113" "332.1" "351.7" "374.0" "358.6" "350.2" "388.8" "386.6" "385.5" "384.4" "369.5" "" "" "" "" "" "" "" "" "" "" "332.1" "297.5" "236.5" "261.5" "286.9" "302.0" "298.0" "331.5" "300.1" "332.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "38.257" "11" "8" "11" "8" "826" "92.4" "5.96" "32.29" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "" "HATs acetylate histones" "1" "0" "1.090" "0.813" "1.106" "1.052" "0.882" "1.072" "1.013" "0.913" "1.035" "284.5" "310.0" "231.4" "314.8" "299.4" "250.8" "305.1" "288.3" "259.7" "294.6" "" "" "" "" "" "" "" "" "" "" "284.5" "262.3" "146.3" "229.5" "245.3" "194.8" "235.2" "247.8" "202.7" "264.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "38.222" "34" "7" "15" "7" "258" "27.3" "6.40" "55.59" "7" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "0.954" "1.122" "1.023" "0.973" "1.119" "1.168" "0.963" "0.984" "0.978" "1062.8" "1013.8" "1193.0" "1087.3" "1034.1" "1189.1" "1241.0" "1023.5" "1046.0" "1039.6" "" "" "" "" "" "" "" "" "" "" "1062.8" "857.7" "754.3" "792.8" "847.2" "923.4" "956.6" "880.0" "816.5" "934.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "38.181" "7" "6" "11" "1" "953" "107.4" "6.16" "41.35" "6" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "38.151" "7" "6" "10" "5" "871" "97.6" "5.81" "34.78" "6" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "2" "0" "0.867" "1.020" "0.830" "0.977" "0.919" "0.976" "0.847" "0.949" "0.897" "223.0" "193.3" "227.6" "185.1" "218.0" "205.0" "217.6" "189.0" "211.6" "200.0" "" "" "" "" "" "" "" "" "" "" "223.0" "163.5" "143.9" "135.0" "178.6" "159.2" "167.7" "162.5" "165.1" "179.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "38.127" "8" "8" "8" "8" "1332" "150.2" "5.94" "29.95" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HDAC6 interactions in the central nervous system" "HATs acetylate histones" "2" "0" "1.090" "0.894" "1.165" "1.144" "0.965" "1.139" "1.015" "1.001" "1.179" "88.5" "96.5" "79.1" "103.2" "101.3" "85.5" "100.8" "89.8" "88.6" "104.4" "" "" "" "" "" "" "" "" "" "" "88.5" "81.7" "50.0" "75.2" "83.0" "66.4" "77.7" "77.2" "69.1" "93.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "38.053" "18" "5" "16" "5" "302" "33.8" "5.49" "55.28" "5" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.984" "1.023" "1.031" "0.944" "0.926" "0.985" "0.974" "1.042" "1.043" "553.0" "544.3" "565.7" "569.9" "522.1" "511.9" "544.9" "538.4" "576.3" "576.6" "" "" "" "" "" "" "" "" "" "" "553.0" "460.5" "357.7" "415.5" "427.8" "397.6" "420.0" "462.9" "449.8" "518.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "38.042" "13" "10" "20" "9" "671" "74.3" "7.49" "63.34" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "1.042" "1.013" "1.029" "1.080" "1.014" "1.064" "1.040" "0.996" "1.054" "1123.1" "1169.8" "1137.4" "1156.2" "1213.0" "1138.8" "1194.8" "1167.8" "1118.4" "1184.2" "" "" "" "" "" "" "" "" "" "" "1123.1" "989.6" "719.2" "843.0" "993.9" "884.4" "921.0" "1004.1" "873.0" "1064.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "37.995" "23" "7" "14" "7" "313" "34.8" "5.60" "44.16" "7" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.923" "1.060" "0.949" "0.947" "1.039" "0.885" "1.005" "0.996" "0.989" "720.5" "665.3" "763.4" "683.7" "682.3" "748.3" "637.9" "724.3" "717.5" "712.8" "" "" "" "" "" "" "" "" "" "" "720.5" "562.9" "482.7" "498.5" "559.0" "581.1" "491.7" "622.8" "560.0" "640.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "37.987" "26" "6" "12" "6" "322" "35.5" "5.48" "38.70" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "Sterol regulatory element-binding proteins (SREBP) signaling" "Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; MHC class II antigen presentation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; HCMV Late Events; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Postmitotic nuclear pore complex (NPC) reformation" "40" "0" "1.059" "0.871" "1.049" "1.027" "0.946" "1.031" "1.068" "0.915" "1.009" "524.9" "555.7" "457.0" "550.7" "539.2" "496.7" "541.0" "560.6" "480.3" "529.8" "" "" "" "" "" "" "" "" "" "" "524.9" "470.1" "289.0" "401.5" "441.8" "385.7" "417.0" "482.0" "374.9" "476.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "High" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.000" "False" "37.952" "15" "8" "10" "5" "536" "60.0" "4.98" "37.85" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "" "Assembly of the ORC complex at the origin of replication" "1" "0" "1.081" "0.918" "1.049" "1.066" "1.040" "1.181" "1.104" "0.969" "1.067" "283.7" "306.5" "260.4" "297.6" "302.6" "295.1" "335.2" "313.1" "274.9" "302.6" "" "" "" "" "" "" "" "" "" "" "283.7" "259.3" "164.6" "217.0" "247.9" "229.2" "258.4" "269.2" "214.6" "272.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "37.928" "28" "5" "14" "5" "253" "28.8" "5.59" "47.96" "5" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "0.981" "1.117" "0.885" "0.987" "1.194" "0.946" "1.027" "1.059" "1.061" "572.7" "561.7" "639.8" "507.1" "565.1" "683.7" "541.5" "588.1" "606.7" "607.4" "" "" "" "" "" "" "" "" "" "" "572.7" "475.2" "404.5" "369.7" "463.0" "531.0" "417.4" "505.6" "473.6" "546.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.000" "False" "37.923" "11" "10" "12" "10" "963" "109.7" "5.45" "32.62" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "2" "0" "1.118" "0.894" "1.094" "1.099" "0.962" "1.064" "1.074" "0.924" "1.038" "252.6" "282.5" "225.8" "276.3" "277.7" "242.9" "268.7" "271.2" "233.5" "262.1" "" "" "" "" "" "" "" "" "" "" "252.6" "239.0" "142.8" "201.5" "227.5" "188.6" "207.1" "233.2" "182.2" "235.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "37.912" "27" "9" "13" "9" "404" "45.5" "5.07" "34.57" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Factors involved in megakaryocyte development and platelet production; GPER1 signaling; FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "22" "0" "1.011" "1.101" "0.963" "1.023" "1.136" "1.038" "1.080" "1.105" "0.992" "566.2" "572.4" "623.7" "545.4" "579.3" "643.0" "588.0" "611.6" "625.6" "561.7" "" "" "" "" "" "" "" "" "" "" "566.2" "484.3" "394.3" "397.6" "474.6" "499.3" "453.2" "525.8" "488.3" "505.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "37.910" "20" "8" "9" "8" "406" "46.9" "8.37" "31.20" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "1.026" "1.005" "0.931" "0.968" "0.966" "0.956" "0.989" "1.003" "0.989" "688.2" "705.9" "691.4" "640.7" "666.1" "665.1" "658.1" "680.8" "690.6" "680.9" "" "" "" "" "" "" "" "" "" "" "688.2" "597.2" "437.2" "467.2" "545.8" "516.5" "507.3" "585.4" "539.1" "612.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "37.906" "13" "7" "10" "7" "672" "75.6" "4.75" "34.30" "7" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "0.947" "0.650" "1.007" "0.935" "0.635" "0.980" "1.050" "0.650" "0.848" "187.3" "177.4" "121.8" "188.6" "175.2" "119.0" "183.5" "196.7" "121.8" "158.9" "" "" "" "" "" "" "" "" "" "" "187.3" "150.0" "77.0" "137.5" "143.6" "92.4" "141.5" "169.2" "95.1" "142.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "37.896" "24" "4" "17" "2" "181" "20.6" "7.43" "43.61" "4" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "3" "0" "0.969" "1.144" "1.039" "1.032" "1.055" "1.038" "0.991" "1.057" "1.003" "764.9" "741.3" "875.1" "794.6" "789.7" "806.9" "794.1" "757.6" "808.3" "767.2" "" "" "" "" "" "" "" "" "" "" "764.9" "627.2" "553.3" "579.4" "647.0" "626.6" "612.1" "651.4" "630.9" "689.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "37.875" "2" "12" "13" "12" "4857" "529.9" "6.05" "38.97" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "2" "0" "1.046" "0.910" "1.046" "0.992" "0.934" "1.042" "0.970" "0.852" "0.964" "787.8" "824.4" "716.8" "823.8" "781.8" "735.6" "821.0" "764.4" "670.8" "759.8" "" "" "" "" "" "" "" "" "" "" "787.8" "697.4" "453.2" "600.7" "640.5" "571.2" "632.9" "657.2" "523.6" "683.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "37.758" "17" "8" "10" "8" "501" "54.1" "6.24" "34.70" "8" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "1.052" "0.735" "0.926" "0.958" "0.751" "0.991" "1.036" "0.749" "0.963" "709.6" "746.5" "521.9" "657.4" "679.8" "533.1" "702.9" "735.3" "531.9" "683.3" "" "" "" "" "" "" "" "" "" "" "709.6" "631.6" "330.0" "479.4" "556.9" "414.0" "541.8" "632.2" "415.2" "614.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "37.749" "19" "5" "12" "5" "297" "33.3" "5.25" "43.95" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "2" "0" "1.024" "0.830" "1.107" "1.072" "0.878" "1.195" "1.064" "0.926" "1.028" "485.0" "496.5" "402.5" "537.0" "519.7" "425.8" "579.5" "516.2" "449.0" "498.7" "" "" "" "" "" "" "" "" "" "" "485.0" "420.1" "254.5" "391.5" "425.8" "330.6" "446.7" "443.8" "350.5" "448.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "37.637" "6" "10" "12" "10" "1555" "172.9" "8.48" "33.33" "10" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "5" "0" "1.074" "0.890" "1.110" "1.118" "1.029" "1.180" "1.147" "0.960" "1.051" "476.3" "511.8" "423.9" "529.0" "532.5" "490.4" "562.0" "546.3" "457.4" "500.8" "" "" "" "" "" "" "" "" "" "" "476.3" "433.0" "268.0" "385.7" "436.3" "380.8" "433.2" "469.7" "357.0" "450.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "37.538" "22" "9" "17" "9" "423" "48.6" "7.30" "43.21" "9" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "5" "0" "1.012" "1.089" "0.949" "0.979" "0.936" "0.943" "0.933" "1.036" "0.913" "664.2" "672.3" "723.2" "630.3" "650.2" "621.4" "626.2" "620.0" "687.8" "606.7" "" "" "" "" "" "" "" "" "" "" "664.2" "568.7" "457.3" "459.6" "532.8" "482.6" "482.7" "533.1" "536.9" "545.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "37.486" "11" "7" "13" "7" "631" "73.9" "6.05" "36.49" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "4" "0" "1.337" "0.999" "1.045" "1.076" "0.869" "1.072" "1.061" "0.882" "1.009" "180.0" "240.7" "179.9" "188.1" "193.7" "156.4" "193.0" "191.1" "158.9" "181.7" "" "" "" "" "" "" "" "" "" "" "180.0" "203.7" "113.8" "137.2" "158.7" "121.5" "148.8" "164.3" "124.0" "163.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "37.425" "19" "8" "16" "8" "463" "50.5" "9.52" "41.33" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "0.977" "0.968" "1.009" "1.035" "0.921" "1.084" "1.019" "0.916" "1.019" "501.1" "489.7" "484.8" "505.8" "518.5" "461.6" "543.1" "510.7" "459.0" "510.4" "" "" "" "" "" "" "" "" "" "" "501.1" "414.3" "306.5" "368.8" "424.8" "358.5" "418.7" "439.1" "358.3" "458.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "37.405" "21" "6" "9" "6" "320" "35.6" "6.13" "34.45" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.068" "1.075" "0.986" "1.127" "1.117" "1.101" "1.140" "1.009" "0.998" "608.8" "650.3" "654.6" "600.4" "686.1" "679.9" "670.0" "693.7" "614.2" "607.6" "" "" "" "" "" "" "" "" "" "" "608.8" "550.2" "413.9" "437.8" "562.1" "528.0" "516.5" "596.5" "479.4" "546.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1450740357169926082" "False" "High" "IsMasterProtein" "P40121" "Macrophage-capping protein OS=Homo sapiens OX=9606 GN=CAPG PE=1 SV=2" "0.000" "False" "37.324" "16" "5" "9" "5" "348" "38.5" "6.19" "31.12" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "822" "ENSG00000042493" "CAPG" "B8ZZS7; D6W5K8; hsa:822; P40121; Q53SA7" "TYROBP causal network in microglia" "" "1" "0" "1.058" "1.048" "1.179" "1.220" "1.075" "1.081" "1.195" "1.187" "1.131" "106.5" "112.7" "111.5" "125.5" "129.9" "114.4" "115.1" "127.2" "126.3" "120.5" "" "" "" "" "" "" "" "" "" "" "106.5" "95.3" "70.5" "91.5" "106.4" "88.9" "88.7" "109.4" "98.6" "108.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "37.293" "23" "6" "25" "6" "228" "26.2" "8.25" "75.38" "6" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "Gastric cancer network 2" "" "1" "0" "0.952" "1.016" "0.887" "0.951" "0.928" "0.930" "1.010" "0.948" "0.927" "1425.2" "1356.7" "1447.8" "1264.7" "1355.8" "1322.9" "1325.5" "1439.4" "1350.5" "1321.1" "" "" "" "" "" "" "" "" "" "" "1425.2" "1147.8" "915.4" "922.1" "1110.8" "1027.4" "1021.7" "1237.6" "1054.2" "1187.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "37.194" "22" "9" "13" "8" "406" "46.6" "6.16" "36.74" "9" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "1.146" "1.068" "1.098" "1.164" "1.122" "1.163" "1.164" "1.122" "1.158" "249.0" "285.2" "265.8" "273.5" "289.9" "279.5" "289.6" "289.8" "279.3" "288.3" "" "" "" "" "" "" "" "" "" "" "249.0" "241.3" "168.1" "199.4" "237.5" "217.0" "223.2" "249.2" "218.0" "259.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "37.121" "33" "8" "16" "6" "271" "30.5" "6.29" "51.82" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Selenium micronutrient network" "Neutrophil degranulation" "2" "0" "1.080" "1.069" "1.116" "1.113" "1.052" "1.128" "1.133" "1.157" "1.156" "355.6" "383.9" "380.2" "396.6" "395.7" "374.0" "401.1" "402.8" "411.3" "411.0" "" "" "" "" "" "" "" "" "" "" "355.6" "324.8" "240.4" "289.2" "324.2" "290.4" "309.2" "346.3" "321.0" "369.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "37.101" "14" "8" "10" "8" "583" "66.7" "5.11" "33.41" "8" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "1.050" "0.962" "1.032" "1.065" "0.952" "0.969" "1.031" "0.898" "1.047" "564.8" "593.2" "543.1" "582.6" "601.7" "537.6" "547.0" "582.4" "507.3" "591.3" "" "" "" "" "" "" "" "" "" "" "564.8" "501.8" "343.4" "424.8" "493.0" "417.5" "421.7" "500.7" "396.0" "531.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4895248664825856717" "False" "High" "IsMasterProtein" "Q9UGP4" "LIM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMD1 PE=1 SV=1" "0.000" "False" "37.064" "13" "6" "8" "6" "676" "72.1" "6.65" "33.06" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "8994" "ENSG00000144791" "LIMD1" "hsa:8994; Q17RQ1; Q9BQQ9; Q9NQ47; Q9UGP4" "Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "3" "0" "1.101" "0.908" "1.134" "1.008" "0.958" "1.107" "1.082" "0.950" "1.016" "390.2" "429.6" "354.3" "442.5" "393.5" "373.6" "432.1" "422.0" "370.6" "396.4" "" "" "" "" "" "" "" "" "" "" "390.2" "363.5" "224.1" "322.7" "322.4" "290.2" "333.1" "362.8" "289.3" "356.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "37.043" "8" "8" "11" "8" "1125" "128.8" "6.35" "39.38" "8" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "1.018" "0.980" "0.958" "0.964" "0.958" "0.946" "0.971" "0.948" "1.034" "639.3" "651.2" "626.5" "612.7" "616.5" "612.8" "604.6" "620.9" "605.9" "661.3" "" "" "" "" "" "" "" "" "" "" "639.3" "550.9" "396.2" "446.7" "505.1" "475.9" "466.1" "533.8" "472.9" "594.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "37.041" "21" "6" "11" "5" "376" "42.6" "6.64" "42.91" "6" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "HDAC6 interactions in the central nervous system" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "1" "0.951" "1.058" "0.962" "0.985" "1.062" "0.959" "0.952" "1.050" "0.958" "838.7" "797.8" "887.1" "806.6" "825.8" "890.9" "804.1" "798.6" "880.7" "803.1" "" "" "" "" "" "" "" "" "" "" "838.7" "674.9" "560.9" "588.1" "676.6" "691.8" "619.8" "686.6" "687.4" "722.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "37.039" "33" "6" "15" "4" "180" "20.5" "6.79" "40.52" "6" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "1" "0.970" "1.045" "0.941" "0.878" "0.926" "0.902" "0.985" "0.893" "0.913" "278.6" "270.3" "291.3" "262.2" "244.6" "258.0" "251.4" "274.4" "248.8" "254.4" "" "" "" "" "" "" "" "" "" "" "278.6" "228.7" "184.2" "191.1" "200.4" "200.4" "193.8" "235.9" "194.2" "228.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-525798378457225330" "False" "High" "IsMasterProtein" "P0CG39" "POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=1 SV=1" "0.000" "False" "37.030" "5" "4" "39" "1" "1038" "117.3" "5.97" "138.10" "4" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "653781" "ENSG00000222038" "POTEJ" "hsa:653781; P0CG39" "" "" "0" "0" "0.809" "0.978" "0.908" "0.806" "0.886" "0.781" "0.948" "1.025" "1.228" "304.2" "246.0" "297.5" "276.3" "245.0" "269.6" "237.6" "288.4" "311.7" "373.6" "" "" "" "" "" "" "" "" "" "" "304.2" "208.1" "188.1" "201.4" "200.7" "209.3" "183.2" "248.0" "243.3" "335.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "36.998" "14" "10" "12" "10" "642" "73.9" "5.60" "39.89" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.937" "0.635" "0.969" "0.929" "0.731" "1.027" "0.908" "0.651" "0.862" "682.8" "639.9" "433.5" "661.4" "634.4" "499.2" "701.3" "619.8" "444.8" "588.5" "" "" "" "" "" "" "" "" "" "" "682.8" "541.4" "274.1" "482.2" "519.8" "387.7" "540.6" "532.9" "347.2" "529.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "36.993" "13" "9" "10" "9" "792" "90.0" "7.15" "31.34" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "4" "0" "0.902" "0.906" "1.011" "0.938" "0.970" "0.945" "0.815" "0.836" "0.961" "423.0" "381.7" "383.1" "427.8" "396.8" "410.2" "399.6" "344.8" "353.6" "406.7" "" "" "" "" "" "" "" "" "" "" "423.0" "322.9" "242.2" "312.0" "325.1" "318.6" "308.0" "296.5" "276.0" "365.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "36.989" "13" "9" "10" "9" "741" "83.5" "5.69" "34.67" "9" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "Ciliary landscape" "tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "29" "0" "0.924" "0.821" "1.038" "1.017" "0.924" "0.955" "1.020" "0.838" "0.939" "545.5" "504.2" "447.6" "566.4" "554.7" "503.8" "521.1" "556.1" "457.3" "512.4" "" "" "" "" "" "" "" "" "" "" "545.5" "426.5" "283.0" "413.0" "454.5" "391.2" "401.7" "478.2" "357.0" "460.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8006254010702621328" "False" "High" "IsMasterProtein" "Cont_P08779" "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" "0.000" "True" "36.952" "21" "10" "18" "2" "473" "51.2" "5.05" "47.03" "10" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3868" "ENSG00000186832" "KRT16" "A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8" "Vitamin D receptor pathway" "Formation of the cornified envelope" "3" "0" "0.709" "0.515" "0.591" "0.673" "1.122" "1.697" "0.521" "0.699" "0.506" "250.5" "177.5" "128.9" "148.0" "168.7" "281.1" "425.2" "130.4" "175.0" "126.7" "" "" "" "" "" "" "" "" "" "" "250.5" "150.2" "81.5" "107.9" "138.2" "218.3" "327.7" "112.1" "136.6" "113.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "36.826" "20" "11" "14" "11" "538" "60.6" "8.03" "48.17" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "1.052" "0.989" "1.003" "0.958" "1.019" "0.907" "0.945" "1.025" "1.059" "1134.5" "1193.7" "1121.5" "1137.6" "1086.4" "1156.6" "1029.2" "1072.4" "1163.1" "1201.7" "" "" "" "" "" "" "" "" "" "" "1134.5" "1009.9" "709.2" "829.5" "890.1" "898.2" "793.4" "922.0" "907.9" "1080.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "36.809" "9" "4" "7" "2" "601" "63.8" "5.22" "29.16" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "2" "0.987" "0.990" "1.009" "1.108" "1.088" "1.063" "1.067" "0.982" "1.055" "238.2" "235.2" "235.9" "240.4" "263.9" "259.2" "253.2" "254.3" "234.0" "251.3" "" "" "" "" "" "" "" "" "" "" "238.2" "199.0" "149.2" "175.3" "216.2" "201.3" "195.2" "218.6" "182.7" "225.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "36.762" "18" "5" "17" "5" "314" "35.8" "4.74" "56.03" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "0.935" "0.901" "1.073" "0.994" "0.928" "1.078" "1.037" "0.871" "0.999" "343.9" "321.6" "309.9" "369.1" "341.9" "319.3" "370.8" "356.5" "299.7" "343.7" "" "" "" "" "" "" "" "" "" "" "343.9" "272.1" "195.9" "269.2" "280.1" "247.9" "285.8" "306.5" "234.0" "309.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.000" "False" "36.761" "11" "9" "10" "9" "991" "109.6" "7.68" "28.02" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.045" "0.901" "1.019" "1.018" "0.954" "1.034" "1.018" "0.902" "1.035" "359.2" "375.3" "323.8" "366.0" "365.6" "342.8" "371.6" "365.7" "324.2" "371.7" "" "" "" "" "" "" "" "" "" "" "359.2" "317.5" "204.7" "266.9" "299.5" "266.2" "286.5" "314.4" "253.0" "334.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "36.750" "27" "6" "14" "6" "234" "25.5" "8.51" "39.99" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage; G1/S-Specific Transcription" "4" "0" "0.985" "0.944" "1.044" "0.970" "0.855" "0.991" "1.035" "0.879" "1.066" "701.1" "690.8" "661.7" "732.3" "680.2" "599.7" "695.1" "725.5" "616.2" "747.3" "" "" "" "" "" "" "" "" "" "" "701.1" "584.5" "418.4" "533.9" "557.3" "465.7" "535.8" "623.8" "481.0" "671.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2083560476411538397" "False" "High" "IsMasterProtein" "O15047" "Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3" "0.000" "False" "36.650" "6" "8" "10" "8" "1707" "185.9" "5.14" "31.50" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00856, Pf11764" "9739" "ENSG00000099381" "SETD1A" "A6NP62; hsa:9739; O15047; Q6PIF3; Q8TAJ6" "Histone modifications" "Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "4" "0" "0.956" "0.762" "0.901" "1.001" "0.917" "1.039" "0.986" "0.779" "0.948" "313.7" "299.9" "239.2" "282.6" "314.0" "287.8" "325.8" "309.4" "244.3" "297.5" "" "" "" "" "" "" "" "" "" "" "313.7" "253.7" "151.2" "206.1" "257.2" "223.5" "251.2" "266.0" "190.7" "267.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "36.634" "10" "7" "9" "7" "750" "83.1" "6.93" "31.73" "7" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Vitamin B12 metabolism; Amino acid metabolism" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "6" "0" "0.990" "0.879" "1.109" "1.160" "0.935" "0.910" "1.110" "1.018" "1.042" "54.3" "53.8" "47.8" "60.3" "63.0" "50.8" "49.5" "60.3" "55.3" "56.6" "" "" "" "" "" "" "" "" "" "" "54.3" "45.5" "30.2" "44.0" "51.6" "39.4" "38.1" "51.9" "43.2" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "36.585" "42" "8" "11" "8" "239" "27.6" "4.84" "41.64" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "0.992" "1.088" "0.949" "1.042" "1.056" "0.996" "1.001" "1.039" "1.040" "664.9" "659.6" "723.5" "630.9" "692.6" "702.2" "662.2" "665.6" "690.6" "691.2" "" "" "" "" "" "" "" "" "" "" "664.9" "558.0" "457.5" "460.0" "567.4" "545.3" "510.4" "572.3" "539.0" "621.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "36.546" "28" "8" "12" "7" "352" "39.6" "5.19" "39.06" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "VEGFA-VEGFR2 signaling" "Striated Muscle Contraction; RND3 GTPase cycle; RHOBTB2 GTPase cycle" "4" "0" "1.091" "1.001" "1.133" "1.125" "1.114" "1.127" "1.067" "1.061" "1.195" "396.4" "432.7" "396.8" "449.3" "446.1" "441.7" "446.8" "422.8" "420.6" "473.9" "" "" "" "" "" "" "" "" "" "" "396.4" "366.0" "250.9" "327.6" "365.5" "343.0" "344.4" "363.5" "328.3" "426.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "36.520" "16" "9" "16" "9" "537" "59.0" "5.83" "48.33" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "1.006" "1.027" "0.959" "1.051" "1.021" "0.981" "1.041" "1.012" "1.059" "1021.6" "1028.0" "1049.4" "979.4" "1073.8" "1042.9" "1002.0" "1063.4" "1034.2" "1081.9" "" "" "" "" "" "" "" "" "" "" "1021.6" "869.7" "663.6" "714.1" "879.8" "809.9" "772.3" "914.3" "807.2" "972.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "36.516" "24" "7" "11" "7" "325" "35.4" "8.38" "40.00" "7" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "" "Mitochondrial translation elongation" "1" "0" "0.950" "0.950" "1.000" "0.987" "0.943" "0.964" "0.973" "0.901" "1.003" "733.5" "697.1" "696.8" "733.2" "723.6" "691.4" "707.0" "713.6" "661.0" "735.7" "" "" "" "" "" "" "" "" "" "" "733.5" "589.7" "440.6" "534.6" "592.9" "536.9" "545.0" "613.6" "516.0" "661.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "36.474" "15" "5" "10" "5" "397" "44.8" "7.08" "39.45" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "4" "0" "0.975" "0.770" "0.866" "1.006" "0.932" "0.971" "1.090" "0.782" "0.861" "419.4" "408.8" "323.1" "363.2" "422.1" "390.9" "407.3" "457.3" "328.1" "361.0" "" "" "" "" "" "" "" "" "" "" "419.4" "345.9" "204.3" "264.8" "345.9" "303.6" "314.0" "393.2" "256.1" "324.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "36.339" "16" "9" "11" "9" "569" "63.5" "4.78" "38.29" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "Ciliary landscape; 16p11.2 distal deletion syndrome" "" "2" "0" "1.012" "0.809" "1.100" "1.105" "0.880" "1.047" "1.075" "0.803" "1.029" "264.0" "267.2" "213.7" "290.4" "291.7" "232.3" "276.5" "283.8" "212.1" "271.7" "" "" "" "" "" "" "" "" "" "" "264.0" "226.0" "135.1" "211.7" "239.0" "180.4" "213.1" "244.0" "165.6" "244.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "36.332" "7" "7" "8" "7" "1093" "119.7" "7.66" "30.42" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "Sterol regulatory element-binding proteins (SREBP) signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.080" "0.892" "1.062" "1.057" "0.953" "1.109" "1.028" "0.963" "1.135" "295.5" "319.2" "263.7" "313.8" "312.4" "281.5" "327.8" "303.7" "284.7" "335.3" "" "" "" "" "" "" "" "" "" "" "295.5" "270.1" "166.7" "228.8" "255.9" "218.6" "252.7" "261.1" "222.2" "301.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001709167677346758" "False" "High" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "0.000" "False" "36.299" "21" "9" "13" "9" "439" "49.9" "8.60" "42.94" "9" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "VEGFA-VEGFR2 signaling" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.031" "0.976" "1.028" "1.033" "1.008" "1.059" "1.025" "0.946" "1.026" "641.5" "661.6" "626.3" "659.6" "662.8" "646.5" "679.5" "657.4" "607.1" "658.0" "" "" "" "" "" "" "" "" "" "" "641.5" "559.7" "396.0" "481.0" "543.0" "502.1" "523.8" "565.3" "473.9" "591.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "36.286" "38" "5" "13" "5" "172" "20.0" "4.58" "38.87" "5" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.980" "0.755" "0.968" "1.007" "0.844" "1.001" "0.975" "0.845" "0.963" "750.8" "736.1" "566.7" "726.8" "756.1" "633.3" "751.7" "732.1" "634.8" "722.8" "" "" "" "" "" "" "" "" "" "" "750.8" "622.8" "358.3" "529.9" "619.5" "491.8" "579.4" "629.4" "495.5" "649.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "36.204" "21" "8" "13" "8" "415" "48.4" "8.29" "40.37" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "Immune response to tuberculosis; 5q35 copy number variation" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "5" "0" "0.985" "0.951" "1.022" "1.054" "0.966" "1.015" "0.978" "0.965" "0.977" "500.2" "492.5" "475.5" "511.2" "526.9" "483.1" "507.5" "489.2" "482.8" "488.6" "" "" "" "" "" "" "" "" "" "" "500.2" "416.7" "300.7" "372.7" "431.7" "375.2" "391.2" "420.6" "376.9" "439.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "36.199" "28" "7" "15" "7" "290" "33.1" "6.55" "44.79" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.042" "1.057" "1.051" "1.050" "1.052" "0.996" "0.989" "1.034" "1.091" "486.2" "506.4" "513.8" "511.0" "510.5" "511.7" "484.4" "480.9" "502.7" "530.3" "" "" "" "" "" "" "" "" "" "" "486.2" "428.4" "324.9" "372.6" "418.2" "397.4" "373.4" "413.5" "392.4" "476.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "36.155" "30" "6" "13" "6" "223" "24.7" "6.95" "46.63" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.989" "0.907" "0.942" "0.984" "0.971" "1.066" "0.945" "0.927" "0.935" "757.1" "748.6" "686.6" "713.1" "744.6" "735.0" "806.9" "715.6" "702.1" "707.8" "" "" "" "" "" "" "" "" "" "" "757.1" "633.3" "434.2" "520.0" "610.1" "570.8" "622.0" "615.3" "548.0" "636.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "36.147" "41" "6" "13" "6" "154" "16.6" "6.58" "45.66" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.084" "1.075" "1.073" "1.073" "1.161" "1.102" "1.069" "1.098" "1.124" "494.1" "535.7" "531.1" "530.3" "530.3" "573.6" "544.4" "528.1" "542.7" "555.2" "" "" "" "" "" "" "" "" "" "" "494.1" "453.2" "335.8" "386.7" "434.5" "445.5" "419.6" "454.0" "423.6" "499.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216911938682189755" "False" "High" "IsMasterProtein" "Q27J81" "Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2" "0.000" "False" "36.128" "8" "8" "8" "8" "1249" "135.5" "5.38" "27.95" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf02205, Pf06367, Pf06371" "64423" "ENSG00000203485" "INF2" "hsa:64423; Q27J81; Q27J83; Q69YL8; Q6P1X7; Q6PK22; Q86TR7; Q9BRM1; Q9H6N1" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.024" "0.878" "1.118" "1.104" "0.962" "1.175" "1.141" "0.906" "0.999" "268.3" "274.7" "235.5" "299.9" "296.3" "258.1" "315.3" "306.0" "243.1" "267.9" "" "" "" "" "" "" "" "" "" "" "268.3" "232.4" "148.9" "218.7" "242.7" "200.5" "243.0" "263.1" "189.7" "240.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.000" "False" "36.072" "6" "11" "12" "11" "1697" "193.3" "8.12" "35.63" "11" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "3" "0" "0.973" "0.984" "1.012" "0.999" "1.034" "1.062" "0.985" "1.011" "1.027" "899.5" "875.6" "885.5" "910.4" "898.5" "930.4" "954.9" "886.4" "909.6" "923.9" "" "" "" "" "" "" "" "" "" "" "899.5" "740.8" "559.9" "663.8" "736.1" "722.6" "736.1" "762.1" "710.0" "830.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "36.050" "9" "9" "11" "9" "975" "112.5" "5.25" "34.85" "9" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "0.973" "0.966" "1.006" "0.936" "0.951" "1.030" "0.938" "0.974" "1.014" "501.8" "488.1" "484.9" "504.6" "469.6" "477.0" "516.9" "470.5" "488.8" "509.1" "" "" "" "" "" "" "" "" "" "" "501.8" "413.0" "306.6" "368.0" "384.7" "370.5" "398.4" "404.6" "381.6" "457.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "36.048" "17" "10" "11" "10" "602" "68.2" "6.43" "38.49" "10" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "1.028" "0.981" "1.035" "1.090" "0.954" "1.036" "1.028" "0.907" "0.986" "616.6" "633.7" "604.6" "638.0" "671.8" "587.9" "638.6" "633.7" "558.9" "607.8" "" "" "" "" "" "" "" "" "" "" "616.6" "536.1" "382.3" "465.2" "550.4" "456.6" "492.2" "544.9" "436.3" "546.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.000" "False" "36.014" "11" "10" "11" "10" "1009" "112.8" "9.01" "34.16" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway" "9" "0" "1.094" "0.801" "1.108" "1.208" "0.922" "1.155" "1.172" "0.873" "1.054" "262.9" "287.7" "210.7" "291.2" "317.6" "242.4" "303.7" "308.2" "229.6" "277.2" "" "" "" "" "" "" "" "" "" "" "262.9" "243.4" "133.2" "212.4" "260.2" "188.3" "234.1" "265.0" "179.2" "249.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "35.986" "31" "8" "13" "8" "254" "28.9" "5.45" "40.84" "8" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "0.994" "1.075" "1.106" "1.683" "0.995" "1.186" "1.064" "1.010" "0.933" "435.0" "432.4" "467.5" "481.1" "732.1" "433.0" "515.7" "462.8" "439.4" "406.1" "" "" "" "" "" "" "" "" "" "" "435.0" "365.8" "295.6" "350.8" "599.8" "336.3" "397.5" "397.9" "343.0" "365.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "35.939" "16" "8" "10" "8" "547" "62.2" "8.88" "29.30" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "HATs acetylate histones" "3" "0" "1.010" "0.898" "0.951" "0.945" "0.961" "0.955" "1.007" "0.921" "0.954" "401.4" "405.3" "360.5" "381.7" "379.3" "385.8" "383.4" "404.2" "369.6" "382.8" "" "" "" "" "" "" "" "" "" "" "401.4" "342.9" "227.9" "278.3" "310.8" "299.6" "295.5" "347.6" "288.5" "344.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "35.934" "34" "8" "17" "2" "207" "23.6" "9.07" "55.03" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "Ectoderm differentiation; Ectoderm differentiation" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "1.023" "1.077" "1.120" "0.887" "1.001" "0.950" "0.995" "1.007" "0.951" "264.7" "270.7" "284.9" "296.3" "234.8" "264.9" "251.3" "263.4" "266.6" "251.7" "" "" "" "" "" "" "" "" "" "" "264.7" "229.0" "180.2" "216.1" "192.4" "205.7" "193.7" "226.5" "208.1" "226.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "35.926" "15" "8" "9" "8" "627" "70.7" "8.56" "28.58" "8" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.836" "0.936" "0.817" "0.982" "1.006" "0.882" "0.966" "0.985" "1.045" "69.9" "58.4" "65.4" "57.1" "68.6" "70.3" "61.6" "67.5" "68.8" "73.0" "" "" "" "" "" "" "" "" "" "" "69.9" "49.4" "41.4" "41.6" "56.2" "54.6" "47.5" "58.0" "53.7" "65.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "35.922" "13" "10" "15" "10" "772" "83.4" "7.20" "41.64" "10" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "White fat cell differentiation" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent gene expression; Repression of WNT target genes" "5" "0" "1.026" "1.051" "0.980" "1.004" "0.992" "1.065" "1.022" "0.931" "1.028" "875.6" "898.7" "920.2" "858.4" "879.3" "868.4" "932.7" "895.0" "814.8" "900.6" "" "" "" "" "" "" "" "" "" "" "875.6" "760.4" "581.9" "625.9" "720.4" "674.4" "719.0" "769.5" "636.0" "809.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "35.918" "39" "6" "8" "6" "205" "22.9" "6.55" "30.86" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.967" "1.121" "0.882" "0.913" "1.060" "0.915" "0.991" "1.089" "1.098" "576.6" "557.6" "646.4" "508.4" "526.7" "611.0" "527.8" "571.4" "628.2" "633.4" "" "" "" "" "" "" "" "" "" "" "576.6" "471.7" "408.7" "370.7" "431.5" "474.5" "406.8" "491.3" "490.4" "569.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "35.917" "5" "11" "11" "11" "2146" "241.5" "6.55" "35.08" "11" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "0.986" "1.435" "0.959" "0.996" "1.471" "0.976" "1.019" "1.423" "1.217" "530.6" "523.3" "761.6" "509.0" "528.7" "780.6" "518.0" "540.5" "755.1" "645.9" "" "" "" "" "" "" "" "" "" "" "530.6" "442.7" "481.6" "371.1" "433.1" "606.2" "399.3" "464.7" "589.4" "580.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "35.916" "19" "5" "9" "5" "312" "35.1" "6.13" "32.93" "5" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "2" "0" "1.058" "1.156" "1.112" "1.018" "1.087" "1.075" "1.040" "1.066" "1.073" "755.4" "799.0" "873.0" "839.8" "769.1" "821.3" "811.9" "786.0" "805.5" "810.7" "" "" "" "" "" "" "" "" "" "" "755.4" "675.9" "552.0" "612.3" "630.1" "637.8" "625.8" "675.8" "628.7" "728.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "35.915" "47" "8" "39" "1" "152" "17.3" "8.41" "104.41" "8" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Pyrimidine metabolism" "Azathioprine ADME; Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "5" "7" "1.003" "1.112" "0.995" "0.986" "1.049" "0.950" "1.007" "1.051" "1.023" "1950.6" "1956.4" "2168.9" "1941.4" "1922.6" "2045.7" "1853.0" "1963.5" "2050.9" "1994.8" "" "" "" "" "" "" "" "" "" "" "1950.6" "1655.1" "1371.4" "1415.6" "1575.2" "1588.7" "1428.3" "1688.2" "1600.9" "1793.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "35.908" "10" "8" "13" "8" "925" "100.5" "5.80" "36.42" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "1.100" "0.926" "1.135" "1.148" "0.912" "1.111" "1.081" "0.960" "1.050" "396.3" "436.0" "367.1" "450.0" "455.2" "361.4" "440.5" "428.4" "380.6" "416.0" "" "" "" "" "" "" "" "" "" "" "396.3" "368.9" "232.1" "328.1" "372.9" "280.7" "339.6" "368.4" "297.1" "374.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "35.886" "18" "10" "12" "10" "582" "64.8" "5.29" "38.79" "10" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "1.063" "0.925" "0.989" "1.004" "1.155" "1.194" "1.069" "1.033" "0.905" "182.4" "193.9" "168.8" "180.4" "183.1" "210.7" "217.9" "195.0" "188.5" "165.1" "" "" "" "" "" "" "" "" "" "" "182.4" "164.0" "106.7" "131.5" "150.1" "163.6" "167.9" "167.6" "147.2" "148.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "35.806" "9" "6" "8" "6" "721" "82.1" "6.95" "30.19" "6" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.027" "1.043" "1.121" "1.125" "1.071" "1.219" "1.018" "1.076" "1.061" "554.2" "568.9" "577.9" "621.3" "623.6" "593.4" "675.6" "564.2" "596.4" "588.0" "" "" "" "" "" "" "" "" "" "" "554.2" "481.3" "365.4" "453.0" "510.9" "460.8" "520.8" "485.1" "465.5" "528.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "35.793" "7" "3" "14" "1" "446" "49.9" "6.05" "55.07" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "32" "0" "1.148" "1.180" "1.423" "0.998" "1.001" "1.048" "1.115" "1.128" "1.319" "265.0" "304.1" "312.8" "377.1" "264.5" "265.4" "277.7" "295.6" "298.8" "349.5" "" "" "" "" "" "" "" "" "" "" "265.0" "257.3" "197.8" "275.0" "216.7" "206.1" "214.1" "254.1" "233.3" "314.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "35.784" "20" "9" "13" "9" "471" "52.0" "8.00" "43.96" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "" "RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.059" "1.111" "1.013" "1.027" "1.165" "0.990" "0.962" "1.210" "1.014" "651.1" "689.6" "723.6" "659.4" "668.7" "758.5" "644.3" "626.1" "788.1" "660.0" "" "" "" "" "" "" "" "" "" "" "651.1" "583.4" "457.5" "480.8" "547.9" "589.0" "496.6" "538.3" "615.2" "593.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "35.759" "14" "5" "8" "5" "414" "44.7" "6.25" "31.71" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "8" "0" "1.055" "0.754" "1.000" "0.977" "0.748" "0.987" "0.966" "0.746" "0.889" "745.3" "786.1" "562.2" "745.6" "728.0" "557.5" "735.6" "720.1" "556.3" "662.2" "" "" "" "" "" "" "" "" "" "" "745.3" "665.0" "355.5" "543.6" "596.5" "432.9" "567.0" "619.1" "434.2" "595.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "35.697" "30" "6" "14" "6" "217" "25.1" "6.15" "45.27" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "33" "0" "0.991" "1.057" "1.032" "0.968" "1.036" "0.991" "1.022" "1.009" "1.001" "851.4" "843.6" "899.8" "878.2" "824.4" "882.3" "844.0" "870.4" "859.1" "852.0" "" "" "" "" "" "" "" "" "" "" "851.4" "713.7" "569.0" "640.3" "675.5" "685.2" "650.6" "748.3" "670.6" "766.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "35.680" "28" "5" "7" "5" "223" "25.4" "5.52" "29.62" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "1.120" "0.820" "1.070" "1.104" "0.910" "0.962" "1.000" "0.950" "1.176" "252.3" "282.7" "207.0" "270.0" "278.6" "229.5" "242.6" "252.3" "239.7" "296.8" "" "" "" "" "" "" "" "" "" "" "252.3" "239.2" "130.9" "196.9" "228.2" "178.3" "187.0" "216.9" "187.1" "266.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "35.679" "46" "6" "8" "6" "154" "16.5" "5.25" "29.21" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "1.097" "0.801" "1.013" "1.086" "1.003" "1.132" "0.987" "0.933" "1.049" "143.5" "157.5" "114.9" "145.4" "155.8" "143.9" "162.5" "141.7" "133.9" "150.6" "" "" "" "" "" "" "" "" "" "" "143.5" "133.2" "72.7" "106.0" "127.7" "111.8" "125.2" "121.9" "104.5" "135.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "35.652" "27" "7" "19" "7" "255" "28.4" "5.33" "64.96" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Interleukin-1 signaling; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.035" "1.040" "1.041" "0.993" "1.096" "0.980" "0.987" "1.062" "1.063" "1350.2" "1396.8" "1404.8" "1405.7" "1341.1" "1480.1" "1323.4" "1332.1" "1434.5" "1435.5" "" "" "" "" "" "" "" "" "" "" "1350.2" "1181.7" "888.3" "1025.0" "1098.8" "1149.4" "1020.1" "1145.4" "1119.7" "1290.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "35.590" "7" "9" "9" "9" "1532" "174.7" "6.76" "29.88" "9" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "3" "0" "1.143" "1.129" "1.241" "1.061" "1.052" "1.116" "1.076" "1.153" "1.206" "350.5" "400.6" "395.7" "434.9" "371.8" "368.7" "391.2" "377.1" "404.3" "422.6" "" "" "" "" "" "" "" "" "" "" "350.5" "338.9" "250.2" "317.1" "304.7" "286.3" "301.5" "324.3" "315.6" "380.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "35.536" "29" "5" "7" "5" "263" "28.3" "8.38" "28.17" "5" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.079" "1.115" "1.090" "1.233" "1.093" "1.154" "1.160" "1.031" "1.130" "137.3" "148.2" "153.1" "149.7" "169.3" "150.1" "158.5" "159.2" "141.6" "155.1" "" "" "" "" "" "" "" "" "" "" "137.3" "125.4" "96.8" "109.2" "138.7" "116.6" "122.2" "136.9" "110.5" "139.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "35.501" "18" "5" "8" "5" "359" "39.6" "7.17" "31.45" "5" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Aflatoxin activation and detoxification" "3" "0" "0.998" "1.080" "1.068" "0.998" "0.924" "0.960" "0.962" "1.002" "1.015" "469.8" "468.7" "507.3" "501.6" "468.7" "433.9" "450.9" "451.9" "470.6" "476.7" "" "" "" "" "" "" "" "" "" "" "469.8" "396.6" "320.8" "365.7" "384.0" "336.9" "347.6" "388.6" "367.3" "428.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4650231133703774819" "False" "High" "IsMasterProtein" "Q96RF0" "Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2" "0.000" "False" "35.494" "13" "7" "13" "7" "628" "68.9" "5.68" "41.59" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf10456, Pf14604" "112574" "ENSG00000178996" "SNX18" "B4E2B3; H7BXX3; hsa:112574; Q05BB3; Q0VG02; Q96RF0" "" "Clathrin-mediated endocytosis" "1" "0" "1.100" "0.910" "1.077" "1.086" "0.933" "1.165" "1.081" "0.935" "1.081" "601.5" "661.6" "547.2" "647.6" "653.1" "561.1" "700.7" "650.3" "562.6" "650.3" "" "" "" "" "" "" "" "" "" "" "601.5" "559.7" "346.0" "472.2" "535.1" "435.8" "540.1" "559.1" "439.1" "584.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "35.429" "15" "8" "13" "2" "506" "56.9" "8.24" "30.98" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "35.424" "24" "5" "12" "5" "233" "26.0" "4.79" "41.64" "5" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "1.042" "1.028" "0.944" "1.075" "0.976" "0.926" "0.956" "0.947" "1.057" "435.0" "453.4" "447.3" "410.4" "467.5" "424.6" "402.8" "415.7" "412.0" "459.7" "" "" "" "" "" "" "" "" "" "" "435.0" "383.6" "282.8" "299.2" "383.0" "329.8" "310.5" "357.4" "321.6" "413.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.000" "False" "35.384" "11" "10" "12" "10" "973" "110.1" "6.07" "37.90" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "3" "0" "0.954" "0.881" "0.941" "0.959" "0.921" "0.962" "1.023" "0.900" "0.933" "488.8" "466.3" "430.8" "460.0" "468.5" "449.9" "470.2" "500.1" "439.9" "456.1" "" "" "" "" "" "" "" "" "" "" "488.8" "394.5" "272.4" "335.4" "383.9" "349.4" "362.4" "430.0" "343.4" "410.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "35.379" "21" "7" "11" "4" "318" "34.8" "6.98" "37.34" "7" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "2" "1.116" "1.014" "1.164" "1.129" "1.018" "1.110" "1.116" "1.134" "1.217" "382.6" "426.9" "387.8" "445.4" "431.9" "389.5" "424.7" "427.0" "433.8" "465.4" "" "" "" "" "" "" "" "" "" "" "382.6" "361.2" "245.2" "324.7" "353.9" "302.5" "327.4" "367.1" "338.6" "418.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "35.364" "33" "5" "12" "5" "190" "20.1" "9.26" "40.05" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "0.992" "1.033" "0.987" "1.058" "1.113" "1.163" "0.953" "1.047" "1.060" "720.3" "714.5" "744.0" "710.8" "762.3" "801.4" "837.9" "686.1" "754.4" "763.8" "" "" "" "" "" "" "" "" "" "" "720.3" "604.5" "470.4" "518.2" "624.6" "622.3" "645.9" "589.9" "588.8" "686.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "35.338" "8" "9" "11" "7" "1239" "142.0" "7.46" "29.92" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "7" "0" "1.091" "0.864" "1.010" "1.070" "1.016" "1.098" "1.023" "0.895" "0.850" "294.8" "321.5" "254.7" "297.8" "315.5" "299.3" "323.7" "301.7" "263.9" "250.5" "" "" "" "" "" "" "" "" "" "" "294.8" "272.0" "161.0" "217.1" "258.5" "232.5" "249.5" "259.4" "206.0" "225.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "35.331" "12" "9" "9" "5" "735" "82.7" "7.83" "29.61" "9" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "Recycling pathway of L1; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "26" "1" "0.957" "0.741" "0.807" "0.923" "0.833" "0.980" "1.059" "0.682" "0.914" "369.5" "353.5" "273.9" "298.0" "341.0" "307.6" "362.0" "391.4" "252.1" "337.7" "" "" "" "" "" "" "" "" "" "" "369.5" "299.1" "173.2" "217.3" "279.4" "238.9" "279.0" "336.6" "196.8" "303.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "35.322" "22" "7" "15" "7" "328" "37.1" "6.84" "55.35" "7" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "1.047" "0.965" "1.064" "1.018" "1.010" "1.031" "1.032" "1.032" "0.987" "667.3" "698.7" "644.3" "710.4" "679.5" "674.0" "688.2" "688.5" "688.8" "658.5" "" "" "" "" "" "" "" "" "" "" "667.3" "591.1" "407.4" "518.0" "556.7" "523.4" "530.5" "592.0" "537.6" "592.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "35.293" "15" "7" "10" "7" "502" "52.9" "6.64" "34.07" "7" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle" "13" "0" "1.000" "1.031" "1.037" "0.958" "0.988" "0.972" "0.977" "0.986" "0.976" "604.9" "604.8" "623.6" "627.1" "579.6" "597.9" "588.2" "590.7" "596.3" "590.3" "" "" "" "" "" "" "" "" "" "" "604.9" "511.7" "394.3" "457.3" "474.9" "464.3" "453.4" "507.9" "465.5" "530.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "35.290" "32" "4" "18" "4" "195" "22.0" "5.44" "61.15" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "30" "0" "0.983" "0.799" "1.119" "1.144" "0.782" "1.131" "1.055" "0.781" "0.967" "458.0" "450.2" "366.0" "512.7" "523.8" "358.3" "518.1" "483.2" "357.8" "443.0" "" "" "" "" "" "" "" "" "" "" "458.0" "380.9" "231.4" "373.8" "429.1" "278.3" "399.4" "415.5" "279.3" "398.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "35.232" "9" "6" "8" "6" "709" "79.6" "5.41" "27.72" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "1.074" "1.012" "1.024" "1.072" "0.936" "0.972" "1.084" "1.020" "1.150" "294.1" "315.7" "297.7" "301.2" "315.2" "275.2" "286.0" "318.7" "300.0" "338.2" "" "" "" "" "" "" "" "" "" "" "294.1" "267.1" "188.2" "219.6" "258.2" "213.7" "220.5" "274.1" "234.2" "304.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "35.217" "11" "7" "15" "7" "649" "70.9" "7.39" "44.45" "7" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "PPARA activates gene expression; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "16" "0" "1.004" "1.148" "1.035" "1.042" "1.075" "0.974" "1.043" "1.066" "1.042" "691.9" "694.6" "794.3" "716.2" "720.8" "743.5" "673.7" "721.6" "737.7" "721.1" "" "" "" "" "" "" "" "" "" "" "691.9" "587.6" "502.2" "522.2" "590.5" "577.4" "519.3" "620.4" "575.8" "648.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357381019356623363" "False" "High" "IsMasterProtein" "Q15025" "TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2" "0.000" "False" "35.206" "14" "9" "9" "9" "636" "71.8" "6.62" "31.21" "9" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "10318" "ENSG00000145901" "TNIP1" "A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; hsa:10318; O76008; Q05KP3; Q05KP4; Q15025; Q6N077; Q96EL9; Q99833; Q9H1J3" "RAC1/PAK1/p38/MMP2 pathway" "Ovarian tumor domain proteases" "2" "0" "0.929" "0.859" "1.104" "1.035" "0.887" "1.130" "1.114" "0.878" "0.958" "708.8" "658.3" "608.9" "782.8" "733.8" "628.3" "800.9" "789.6" "622.5" "679.1" "" "" "" "" "" "" "" "" "" "" "708.8" "556.9" "385.0" "570.8" "601.2" "488.0" "617.3" "678.9" "485.9" "610.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "35.156" "18" "9" "11" "9" "647" "69.0" "7.84" "31.47" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "8" "0" "0.999" "0.886" "0.951" "0.982" "0.916" "0.958" "0.895" "0.899" "0.944" "263.1" "262.8" "233.1" "250.1" "258.4" "241.0" "252.1" "235.5" "236.6" "248.3" "" "" "" "" "" "" "" "" "" "" "263.1" "222.3" "147.4" "182.4" "211.7" "187.2" "194.3" "202.5" "184.7" "223.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "35.152" "30" "4" "14" "4" "209" "24.0" "7.81" "44.53" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "Apoptosis induced DNA fragmentation" "4" "0" "0.993" "1.132" "1.087" "0.970" "0.967" "0.917" "0.882" "0.989" "0.899" "1084.1" "1076.3" "1227.1" "1177.9" "1051.3" "1048.1" "994.2" "955.8" "1072.6" "974.7" "" "" "" "" "" "" "" "" "" "" "1084.1" "910.6" "775.9" "858.9" "861.3" "814.0" "766.4" "821.8" "837.2" "876.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "35.125" "23" "8" "15" "8" "386" "42.3" "5.97" "41.69" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "0.915" "1.104" "1.005" "0.988" "1.055" "0.995" "1.068" "0.977" "1.001" "333.9" "305.6" "368.8" "335.5" "330.0" "352.2" "332.2" "356.6" "326.3" "334.3" "" "" "" "" "" "" "" "" "" "" "333.9" "258.5" "233.2" "244.6" "270.4" "273.5" "256.1" "306.6" "254.7" "300.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "35.033" "15" "4" "12" "4" "407" "43.4" "8.56" "40.73" "4" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.059" "1.084" "1.018" "1.054" "0.967" "1.019" "1.102" "1.067" "1.097" "367.1" "388.7" "397.9" "373.6" "387.0" "355.0" "373.9" "404.7" "391.5" "402.7" "" "" "" "" "" "" "" "" "" "" "367.1" "328.8" "251.6" "272.4" "317.1" "275.7" "288.2" "348.0" "305.6" "362.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "35.033" "24" "7" "11" "7" "336" "37.9" "7.12" "35.47" "7" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "0.937" "0.907" "0.928" "0.925" "0.964" "0.951" "0.957" "0.942" "0.999" "658.5" "617.1" "597.2" "611.0" "609.1" "634.9" "626.2" "630.3" "620.3" "657.7" "" "" "" "" "" "" "" "" "" "" "658.5" "522.1" "377.6" "445.5" "499.0" "493.1" "482.7" "541.9" "484.2" "591.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "34.972" "11" "7" "13" "7" "624" "70.8" "6.86" "40.02" "7" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Sulfation biotransformation reaction" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "4" "0" "1.079" "1.003" "0.989" "1.052" "1.036" "1.023" "1.017" "1.005" "0.995" "773.7" "835.1" "776.1" "765.1" "813.6" "801.2" "791.6" "787.0" "777.7" "769.5" "" "" "" "" "" "" "" "" "" "" "773.7" "706.5" "490.7" "557.9" "666.6" "622.2" "610.2" "676.7" "607.0" "691.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3460049962588220827" "False" "High" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "0.000" "False" "34.965" "22" "7" "10" "7" "325" "35.7" "5.64" "32.79" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "1.118" "1.098" "1.052" "1.109" "0.981" "0.958" "1.058" "1.013" "1.008" "203.0" "226.8" "222.9" "213.5" "225.0" "199.1" "194.4" "214.7" "205.6" "204.6" "" "" "" "" "" "" "" "" "" "" "203.0" "191.9" "140.9" "155.6" "184.4" "154.6" "149.8" "184.6" "160.5" "184.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "34.960" "24" "9" "10" "9" "423" "47.7" "5.90" "32.24" "9" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.028" "1.081" "1.032" "1.007" "1.111" "0.989" "1.045" "1.032" "1.015" "656.0" "674.1" "709.1" "676.8" "660.4" "728.6" "648.5" "685.9" "676.8" "665.9" "" "" "" "" "" "" "" "" "" "" "656.0" "570.3" "448.4" "493.5" "541.1" "565.8" "499.9" "589.7" "528.3" "598.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "34.949" "26" "7" "10" "7" "291" "31.8" "5.19" "33.97" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.044" "1.036" "1.017" "1.044" "1.175" "1.073" "1.018" "1.068" "0.999" "512.3" "535.0" "531.0" "520.8" "535.0" "602.0" "549.7" "521.8" "547.1" "511.9" "" "" "" "" "" "" "" "" "" "" "512.3" "452.6" "335.7" "379.7" "438.3" "467.5" "423.8" "448.6" "427.1" "460.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "34.926" "18" "5" "9" "4" "346" "36.9" "6.87" "24.12" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "1.030" "0.990" "0.994" "0.978" "1.136" "1.024" "1.065" "1.012" "1.043" "228.9" "235.7" "226.6" "227.5" "223.9" "260.1" "234.3" "243.7" "231.7" "238.7" "" "" "" "" "" "" "" "" "" "" "228.9" "199.4" "143.3" "165.9" "183.4" "202.0" "180.6" "209.5" "180.8" "214.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "34.887" "37" "4" "13" "4" "115" "11.7" "4.54" "45.96" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "0.980" "1.147" "1.023" "1.074" "1.318" "1.235" "1.111" "1.210" "1.136" "598.5" "586.4" "686.3" "612.4" "642.6" "789.0" "738.8" "664.6" "724.2" "679.7" "" "" "" "" "" "" "" "" "" "" "598.5" "496.1" "434.0" "446.5" "526.5" "612.7" "569.5" "571.4" "565.3" "611.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339242402032558616" "False" "High" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "0.000" "False" "34.879" "14" "7" "10" "6" "517" "56.3" "7.05" "33.49" "7" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "Mitochondrial protein degradation; Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "8" "0" "0.900" "1.055" "0.909" "0.956" "0.989" "0.957" "0.967" "0.939" "1.043" "339.9" "305.9" "358.6" "308.8" "325.1" "336.3" "325.3" "328.8" "319.1" "354.7" "" "" "" "" "" "" "" "" "" "" "339.9" "258.8" "226.7" "225.2" "266.3" "261.2" "250.7" "282.7" "249.1" "318.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "34.862" "10" "10" "12" "10" "2850" "282.2" "10.04" "29.58" "10" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "" "Neutrophil degranulation" "1" "0" "0.347" "0.641" "0.390" "0.338" "0.467" "0.178" "0.300" "0.769" "0.237" "426.3" "148.0" "273.4" "166.3" "143.9" "199.0" "75.7" "127.9" "327.7" "101.0" "" "" "" "" "" "" "" "" "" "" "426.3" "125.2" "172.8" "121.2" "117.9" "154.5" "58.4" "110.0" "255.8" "90.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "34.718" "17" "7" "14" "7" "411" "46.6" "4.88" "47.69" "7" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.012" "0.930" "1.018" "1.001" "0.995" "1.071" "0.975" "1.000" "0.954" "816.8" "826.9" "759.8" "831.2" "817.4" "812.7" "874.6" "796.4" "816.7" "778.9" "" "" "" "" "" "" "" "" "" "" "816.8" "699.5" "480.4" "606.1" "669.7" "631.1" "674.2" "684.7" "637.5" "700.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "34.713" "13" "6" "8" "5" "474" "53.2" "7.08" "24.00" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "1.097" "1.213" "1.276" "1.151" "1.272" "1.073" "1.148" "1.240" "1.091" "156.9" "172.2" "190.2" "200.2" "180.6" "199.5" "168.3" "180.1" "194.6" "171.2" "" "" "" "" "" "" "" "" "" "" "156.9" "145.6" "120.3" "146.0" "148.0" "154.9" "129.7" "154.8" "151.9" "153.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "34.694" "11" "7" "11" "7" "732" "83.3" "6.61" "38.99" "7" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.012" "0.901" "1.085" "1.039" "0.952" "1.080" "1.051" "0.909" "1.136" "590.3" "597.1" "532.1" "640.5" "613.3" "562.0" "637.4" "620.3" "536.6" "670.8" "" "" "" "" "" "" "" "" "" "" "590.3" "505.2" "336.4" "467.0" "502.5" "436.5" "491.3" "533.3" "418.9" "603.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "34.624" "19" "8" "10" "8" "431" "48.3" "6.58" "32.11" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.026" "1.101" "1.081" "1.022" "1.089" "1.055" "1.081" "0.979" "1.028" "629.8" "646.4" "693.6" "680.7" "643.8" "686.1" "664.4" "681.1" "616.5" "647.7" "" "" "" "" "" "" "" "" "" "" "629.8" "546.9" "438.6" "496.3" "527.5" "532.8" "512.2" "585.6" "481.2" "582.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "34.618" "15" "7" "11" "7" "459" "50.9" "4.73" "38.85" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "0.965" "0.902" "1.040" "0.974" "0.915" "0.948" "0.993" "0.960" "0.965" "612.2" "591.0" "552.2" "636.7" "596.5" "560.3" "580.1" "607.8" "587.9" "591.1" "" "" "" "" "" "" "" "" "" "" "612.2" "500.0" "349.1" "464.3" "488.7" "435.1" "447.2" "522.6" "458.9" "531.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "34.608" "15" "7" "10" "7" "538" "59.1" "5.10" "32.88" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "1.131" "0.986" "0.994" "1.096" "1.033" "1.129" "1.116" "1.036" "0.942" "458.5" "518.5" "452.0" "455.7" "502.6" "473.7" "517.9" "511.8" "475.1" "432.1" "" "" "" "" "" "" "" "" "" "" "458.5" "438.6" "285.8" "332.3" "411.8" "367.9" "399.2" "440.0" "370.9" "388.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "34.543" "28" "4" "17" "4" "163" "18.6" "4.54" "58.82" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Circadian Clock; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "39" "0" "0.987" "0.987" "1.032" "1.047" "1.027" "1.237" "1.019" "0.926" "0.974" "1185.9" "1170.7" "1170.8" "1224.1" "1241.3" "1218.2" "1466.8" "1208.4" "1098.0" "1155.2" "" "" "" "" "" "" "" "" "" "" "1185.9" "990.5" "740.3" "892.6" "1017.0" "946.0" "1130.6" "1039.0" "857.1" "1038.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "34.514" "24" "4" "13" "4" "193" "21.8" "6.10" "41.99" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "71" "0" "0.925" "0.988" "0.967" "0.928" "1.050" "1.005" "0.964" "0.926" "0.983" "896.7" "829.4" "885.6" "866.8" "832.1" "941.2" "901.4" "864.1" "830.0" "881.2" "" "" "" "" "" "" "" "" "" "" "896.7" "701.7" "560.0" "632.0" "681.8" "730.9" "694.8" "743.0" "647.9" "792.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "34.438" "15" "7" "12" "7" "520" "56.1" "7.46" "39.37" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "2" "0" "0.972" "1.052" "0.999" "0.984" "1.018" "0.949" "0.936" "1.022" "0.973" "595.7" "578.8" "626.6" "595.3" "586.1" "606.7" "565.5" "557.5" "608.7" "579.4" "" "" "" "" "" "" "" "" "" "" "595.7" "489.7" "396.2" "434.0" "480.2" "471.1" "435.9" "479.3" "475.1" "520.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8016840892543387759" "False" "High" "IsMasterProtein" "Q9P2F8" "Signal-induced proliferation-associated 1-like protein 2 OS=Homo sapiens OX=9606 GN=SIPA1L2 PE=1 SV=2" "0.000" "False" "34.420" "5" "8" "10" "8" "1722" "190.3" "6.77" "30.51" "8" "other biological processes" "other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "57568" "ENSG00000116991" "SIPA1L2" "hsa:57568; Q2TV88; Q5VXR7; Q5VXR8; Q641Q4; Q8NA38; Q96DZ3; Q9H9F6; Q9P2F8" "" "" "0" "0" "1.033" "0.750" "1.133" "1.085" "0.808" "1.062" "1.038" "0.730" "0.901" "209.9" "216.8" "157.4" "237.9" "227.8" "169.7" "222.9" "217.9" "153.3" "189.3" "" "" "" "" "" "" "" "" "" "" "209.9" "183.4" "99.5" "173.4" "186.6" "131.8" "171.8" "187.3" "119.7" "170.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.000" "False" "34.417" "7" "7" "9" "7" "1202" "135.7" "6.29" "29.37" "7" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "7" "0" "0.982" "0.933" "1.001" "1.010" "0.915" "0.974" "0.957" "0.917" "1.044" "341.8" "335.6" "319.0" "342.0" "345.1" "312.7" "333.1" "327.1" "313.5" "356.8" "" "" "" "" "" "" "" "" "" "" "341.8" "283.9" "201.7" "249.4" "282.7" "242.8" "256.7" "281.3" "244.7" "320.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "34.413" "13" "7" "11" "7" "623" "62.7" "4.88" "42.71" "7" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "0.978" "1.074" "1.162" "1.018" "1.112" "1.069" "1.052" "1.080" "1.035" "535.9" "524.1" "575.5" "622.7" "545.4" "596.1" "572.9" "563.8" "578.5" "554.6" "" "" "" "" "" "" "" "" "" "" "535.9" "443.4" "363.9" "454.1" "446.9" "462.9" "441.6" "484.8" "451.6" "498.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "34.384" "20" "6" "8" "6" "419" "45.8" "6.60" "27.82" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "16p11.2 distal deletion syndrome" "" "1" "0" "1.126" "1.067" "1.123" "1.066" "0.995" "1.020" "1.019" "0.976" "0.967" "180.8" "203.6" "192.8" "203.0" "192.7" "179.8" "184.4" "184.1" "176.4" "174.8" "" "" "" "" "" "" "" "" "" "" "180.8" "172.2" "121.9" "148.0" "157.8" "139.7" "142.2" "158.3" "137.7" "157.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "34.354" "11" "8" "10" "7" "893" "97.8" "5.66" "27.49" "8" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "1.035" "0.876" "0.977" "1.056" "0.978" "0.975" "0.999" "0.881" "0.950" "562.8" "582.5" "493.1" "549.6" "594.2" "550.3" "549.0" "562.1" "495.8" "534.7" "" "" "" "" "" "" "" "" "" "" "562.8" "492.8" "311.8" "400.7" "486.8" "427.4" "423.2" "483.3" "387.0" "480.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "34.313" "35" "8" "18" "6" "200" "22.5" "8.38" "57.46" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "5" "0" "0.962" "1.077" "1.019" "0.919" "1.119" "0.962" "1.000" "1.080" "0.967" "550.3" "529.5" "592.5" "560.8" "505.8" "615.8" "529.3" "550.3" "594.0" "532.2" "" "" "" "" "" "" "" "" "" "" "550.3" "448.0" "374.6" "408.9" "414.4" "478.3" "408.0" "473.1" "463.7" "478.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "34.266" "17" "6" "8" "6" "396" "45.4" "8.91" "32.41" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "" "Initiation of Nuclear Envelope (NE) Reformation; Nuclear Envelope Breakdown" "2" "0" "0.990" "0.845" "0.860" "0.928" "0.881" "0.949" "0.876" "0.863" "0.888" "437.4" "433.2" "369.6" "376.4" "406.1" "385.4" "414.9" "383.2" "377.5" "388.3" "" "" "" "" "" "" "" "" "" "" "437.4" "366.5" "233.7" "274.4" "332.8" "299.3" "319.8" "329.4" "294.6" "349.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "34.259" "45" "5" "16" "5" "114" "12.8" "5.25" "51.36" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "1.011" "1.097" "1.036" "1.055" "1.145" "1.145" "1.027" "1.113" "1.100" "707.4" "714.9" "776.1" "733.1" "746.5" "809.8" "809.8" "726.6" "787.3" "778.1" "" "" "" "" "" "" "" "" "" "" "707.4" "604.8" "490.7" "534.6" "611.6" "628.9" "624.2" "624.7" "614.6" "699.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "34.258" "5" "9" "12" "7" "2414" "264.0" "8.50" "38.66" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Transcriptional regulation of granulopoiesis; Metalloprotease DUBs; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; Heme signaling; Regulation of RUNX3 expression and activity; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "91" "2" "0.992" "1.012" "1.105" "1.101" "1.060" "1.198" "1.021" "0.954" "1.073" "343.1" "340.4" "347.4" "379.0" "377.9" "363.8" "411.0" "350.1" "327.3" "368.3" "" "" "" "" "" "" "" "" "" "" "343.1" "288.0" "219.6" "276.3" "309.6" "282.5" "316.8" "301.1" "255.5" "331.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "34.258" "41" "9" "20" "9" "194" "22.6" "10.65" "54.64" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.963" "1.077" "1.005" "1.064" "1.104" "1.066" "1.153" "1.192" "1.083" "1015.8" "978.0" "1093.6" "1020.5" "1080.7" "1121.6" "1082.6" "1170.7" "1210.8" "1100.3" "" "" "" "" "" "" "" "" "" "" "1015.8" "827.5" "691.5" "744.1" "885.4" "871.0" "834.5" "1006.6" "945.1" "989.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "34.231" "16" "7" "9" "7" "485" "53.4" "7.58" "29.35" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "Ciliary landscape" "" "1" "0" "1.085" "1.043" "1.126" "1.026" "1.021" "1.001" "1.047" "1.088" "0.997" "468.5" "508.2" "488.8" "527.3" "480.6" "478.3" "469.2" "490.7" "509.9" "467.0" "" "" "" "" "" "" "" "" "" "" "468.5" "430.0" "309.1" "384.5" "393.7" "371.4" "361.6" "421.9" "398.0" "419.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "34.225" "16" "7" "13" "7" "436" "47.7" "5.85" "40.61" "7" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "1.069" "1.034" "1.038" "1.060" "1.080" "1.090" "1.036" "1.076" "1.044" "268.3" "286.9" "277.4" "278.5" "284.3" "289.6" "292.5" "277.9" "288.6" "280.2" "" "" "" "" "" "" "" "" "" "" "268.3" "242.7" "175.4" "203.1" "232.9" "224.9" "225.4" "238.9" "225.2" "251.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "34.204" "10" "4" "7" "2" "589" "62.5" "5.11" "28.45" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.945" "0.926" "1.095" "1.123" "1.107" "0.988" "0.992" "0.948" "1.047" "141.5" "133.7" "131.1" "155.0" "158.9" "156.7" "139.8" "140.4" "134.2" "148.2" "" "" "" "" "" "" "" "" "" "" "141.5" "113.1" "82.9" "113.0" "130.2" "121.7" "107.8" "120.7" "104.7" "133.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "34.192" "9" "7" "10" "3" "745" "82.8" "7.37" "33.06" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "2" "0.931" "0.942" "0.995" "1.007" "1.022" "0.968" "1.006" "0.870" "0.981" "365.2" "340.0" "344.0" "363.3" "367.6" "373.3" "353.5" "367.2" "317.7" "358.2" "" "" "" "" "" "" "" "" "" "" "365.2" "287.7" "217.5" "264.9" "301.2" "289.9" "272.5" "315.7" "248.0" "322.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8633064063620321085" "False" "High" "IsMasterProtein" "Q6PGP7" "Superkiller complex protein 3 OS=Homo sapiens OX=9606 GN=SKIC3 PE=1 SV=1" "0.000" "False" "34.192" "6" "10" "13" "10" "1564" "175.4" "7.53" "38.73" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf13181, Pf13432, Pf14559" "9652" "ENSG00000198677" "SKIC3" "hsa:9652; O15077; Q6PGP7; Q6PJI3" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.160" "0.878" "1.084" "1.098" "0.949" "0.964" "0.995" "1.010" "1.031" "302.5" "350.9" "265.6" "328.0" "332.0" "287.1" "291.6" "301.0" "305.6" "312.0" "" "" "" "" "" "" "" "" "" "" "302.5" "296.9" "167.9" "239.2" "272.0" "223.0" "224.8" "258.8" "238.6" "280.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "34.187" "8" "8" "8" "8" "955" "108.6" "10.15" "25.69" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Interactome of polycomb repressive complex 2 (PRC2)" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "0" "1.148" "1.351" "1.244" "1.205" "1.499" "1.343" "1.205" "1.362" "1.133" "492.8" "565.8" "665.6" "613.0" "593.9" "738.8" "662.0" "594.0" "671.1" "558.5" "" "" "" "" "" "" "" "" "" "" "492.8" "478.7" "420.9" "446.9" "486.6" "573.7" "510.3" "510.7" "523.9" "502.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "34.099" "44" "6" "11" "6" "129" "14.6" "8.88" "39.92" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.016" "1.076" "1.008" "1.046" "1.164" "1.245" "1.079" "1.050" "1.046" "556.1" "564.9" "598.2" "560.6" "581.9" "647.5" "692.2" "599.9" "583.7" "581.6" "" "" "" "" "" "" "" "" "" "" "556.1" "478.0" "378.2" "408.8" "476.8" "502.8" "533.6" "515.8" "455.6" "522.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "34.071" "29" "9" "15" "6" "360" "41.4" "6.98" "46.06" "9" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "Recycling pathway of L1; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "208" "3" "1.131" "1.021" "1.024" "1.034" "1.006" "1.003" "1.030" "1.077" "1.061" "894.9" "1011.9" "913.6" "916.1" "925.5" "899.9" "897.3" "922.2" "963.4" "949.4" "" "" "" "" "" "" "" "" "" "" "894.9" "856.1" "577.7" "668.0" "758.2" "698.8" "691.6" "792.9" "752.0" "853.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "34.045" "19" "7" "9" "7" "382" "43.9" "7.46" "33.71" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "0.898" "0.902" "0.917" "0.959" "0.904" "0.979" "1.003" "0.944" "0.965" "347.0" "311.7" "312.8" "318.0" "332.6" "313.6" "339.7" "348.1" "327.4" "334.9" "" "" "" "" "" "" "" "" "" "" "347.0" "263.7" "197.8" "231.9" "272.5" "243.6" "261.8" "299.3" "255.6" "301.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "33.970" "17" "7" "12" "7" "453" "48.7" "8.95" "39.99" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "10" "0" "0.992" "0.966" "0.993" "1.093" "1.034" "1.014" "0.917" "0.912" "0.980" "535.2" "531.0" "517.1" "531.4" "584.9" "553.6" "542.9" "491.0" "488.1" "524.4" "" "" "" "" "" "" "" "" "" "" "535.2" "449.3" "327.0" "387.4" "479.2" "429.9" "418.5" "422.1" "381.0" "471.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "33.953" "29" "7" "12" "7" "298" "32.2" "7.39" "33.25" "7" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.014" "1.041" "1.075" "0.970" "1.018" "0.992" "0.984" "1.011" "1.090" "454.0" "460.5" "472.8" "488.2" "440.6" "462.3" "450.2" "446.7" "459.1" "494.6" "" "" "" "" "" "" "" "" "" "" "454.0" "389.6" "298.9" "356.0" "361.0" "359.0" "347.1" "384.1" "358.3" "444.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "33.925" "36" "5" "13" "5" "181" "20.6" "8.87" "46.25" "5" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "" "Neutrophil degranulation" "1" "0" "0.975" "1.207" "0.906" "0.941" "1.173" "1.020" "0.943" "1.161" "1.034" "1072.4" "1045.9" "1294.7" "972.0" "1008.6" "1257.4" "1094.0" "1010.8" "1245.2" "1109.0" "" "" "" "" "" "" "" "" "" "" "1072.4" "884.9" "818.6" "708.7" "826.4" "976.5" "843.3" "869.1" "972.0" "997.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "33.920" "36" "6" "10" "6" "196" "22.2" "5.57" "33.45" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.920" "0.942" "0.929" "0.963" "1.023" "0.982" "0.926" "0.904" "1.031" "492.8" "453.5" "464.4" "457.8" "474.7" "504.0" "483.9" "456.3" "445.4" "507.8" "" "" "" "" "" "" "" "" "" "" "492.8" "383.7" "293.6" "333.8" "389.0" "391.4" "373.0" "392.3" "347.6" "456.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "33.888" "17" "5" "13" "4" "334" "37.9" "7.39" "44.49" "5" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "0" "1.037" "1.161" "1.002" "0.966" "1.075" "0.939" "1.005" "1.014" "1.053" "475.7" "493.5" "552.3" "476.6" "459.5" "511.6" "446.9" "478.0" "482.2" "500.8" "" "" "" "" "" "" "" "" "" "" "475.7" "417.5" "349.2" "347.5" "376.4" "397.3" "344.5" "410.9" "376.4" "450.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "33.862" "58" "7" "15" "7" "125" "14.3" "6.04" "48.39" "7" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.873" "1.118" "0.985" "0.908" "1.050" "1.131" "0.982" "1.093" "0.918" "506.9" "442.3" "566.7" "499.3" "460.1" "532.4" "573.4" "498.0" "554.2" "465.5" "" "" "" "" "" "" "" "" "" "" "506.9" "374.2" "358.3" "364.1" "376.9" "413.5" "442.0" "428.2" "432.6" "418.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "33.837" "30" "5" "15" "5" "174" "19.9" "5.72" "55.18" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.966" "1.255" "0.919" "0.993" "1.272" "1.032" "0.959" "1.176" "1.112" "1478.3" "1427.8" "1855.2" "1358.6" "1468.2" "1880.9" "1525.2" "1418.2" "1738.1" "1644.4" "" "" "" "" "" "" "" "" "" "" "1478.3" "1208.0" "1173.0" "990.6" "1202.9" "1460.7" "1175.7" "1219.4" "1356.7" "1478.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "33.790" "11" "6" "9" "5" "537" "60.1" "5.85" "29.83" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "1" "1.040" "1.314" "1.020" "1.121" "1.278" "1.032" "1.084" "1.233" "1.162" "517.9" "538.5" "680.6" "528.0" "580.5" "662.1" "534.6" "561.4" "638.8" "601.9" "" "" "" "" "" "" "" "" "" "" "517.9" "455.5" "430.3" "385.0" "475.6" "514.2" "412.1" "482.7" "498.6" "541.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "33.734" "27" "8" "12" "8" "309" "33.7" "7.33" "36.44" "8" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Myometrial relaxation and contraction pathways; Burn wound healing" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "0.887" "0.934" "0.854" "0.887" "0.927" "0.968" "0.893" "0.836" "0.886" "623.7" "553.2" "582.5" "532.5" "553.0" "578.4" "603.6" "557.0" "521.3" "552.3" "" "" "" "" "" "" "" "" "" "" "623.7" "468.0" "368.3" "388.3" "453.1" "449.2" "465.3" "478.9" "406.9" "496.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "33.716" "27" "4" "6" "4" "204" "21.6" "5.48" "25.82" "4" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.138" "1.222" "1.124" "1.248" "1.066" "1.206" "1.225" "1.140" "1.072" "153.1" "174.2" "187.2" "172.1" "191.1" "163.3" "184.6" "187.6" "174.6" "164.2" "" "" "" "" "" "" "" "" "" "" "153.1" "147.4" "118.3" "125.5" "156.5" "126.8" "142.3" "161.3" "136.3" "147.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "33.707" "9" "9" "9" "9" "1041" "119.2" "6.80" "31.04" "9" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.017" "0.952" "1.002" "0.977" "0.967" "0.870" "0.944" "1.040" "0.913" "476.8" "484.9" "453.9" "478.0" "465.8" "460.9" "415.0" "449.9" "496.0" "435.5" "" "" "" "" "" "" "" "" "" "" "476.8" "410.3" "287.0" "348.5" "381.6" "357.9" "319.9" "386.9" "387.2" "391.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "33.693" "18" "8" "11" "8" "437" "49.6" "8.12" "33.62" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.114" "0.873" "1.077" "1.117" "0.897" "1.114" "1.109" "0.924" "1.050" "358.1" "398.8" "312.8" "385.5" "399.8" "321.1" "398.8" "397.3" "331.0" "376.1" "" "" "" "" "" "" "" "" "" "" "358.1" "337.4" "197.8" "281.1" "327.6" "249.4" "307.4" "341.6" "258.4" "338.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "33.662" "13" "7" "13" "7" "692" "76.1" "5.15" "40.57" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "G protein signaling pathways" "" "1" "0" "1.032" "1.048" "1.084" "1.060" "1.164" "1.150" "1.092" "1.544" "1.010" "710.0" "732.5" "743.7" "769.3" "752.3" "826.1" "816.6" "775.4" "1096.4" "717.3" "" "" "" "" "" "" "" "" "" "" "710.0" "619.7" "470.3" "560.9" "616.3" "641.5" "629.5" "666.7" "855.8" "644.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "33.646" "8" "9" "11" "8" "1069" "121.7" "5.25" "36.10" "9" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "" "TBC/RABGAPs" "1" "0" "0.978" "0.863" "1.034" "0.997" "0.907" "1.013" "0.989" "0.965" "0.975" "472.0" "461.5" "407.2" "487.8" "470.7" "428.3" "477.9" "466.9" "455.2" "460.4" "" "" "" "" "" "" "" "" "" "" "472.0" "390.5" "257.5" "355.7" "385.7" "332.6" "368.4" "401.5" "355.3" "413.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "33.639" "28" "2" "9" "2" "108" "11.9" "8.16" "34.23" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "14" "0" "1.007" "1.162" "0.973" "1.030" "1.141" "1.024" "0.966" "1.066" "1.050" "705.3" "710.5" "819.4" "686.1" "726.6" "804.5" "722.5" "681.0" "752.2" "740.4" "" "" "" "" "" "" "" "" "" "" "705.3" "601.1" "518.1" "500.3" "595.3" "624.7" "556.9" "585.5" "587.1" "665.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "33.626" "11" "4" "8" "4" "485" "52.7" "4.44" "29.67" "4" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "" "2" "0" "1.073" "1.015" "1.098" "1.069" "1.077" "1.075" "1.082" "1.074" "0.935" "145.2" "155.8" "147.3" "159.4" "155.1" "156.4" "156.0" "157.1" "155.9" "135.7" "" "" "" "" "" "" "" "" "" "" "145.2" "131.8" "93.1" "116.2" "127.1" "121.4" "120.2" "135.1" "121.7" "122.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "33.608" "12" "7" "7" "7" "624" "70.8" "5.48" "25.21" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "Sphingolipid pathway" "" "1" "0" "0.952" "0.855" "0.945" "0.956" "0.838" "0.991" "0.977" "0.862" "0.957" "437.3" "416.3" "373.8" "413.0" "417.8" "366.5" "433.5" "427.4" "377.0" "418.7" "" "" "" "" "" "" "" "" "" "" "437.3" "352.2" "236.3" "301.2" "342.3" "284.6" "334.1" "367.5" "294.3" "376.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "33.560" "13" "7" "8" "7" "582" "66.9" "9.55" "28.77" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.006" "0.959" "1.037" "1.089" "1.017" "1.158" "1.148" "1.021" "0.988" "409.3" "411.8" "392.4" "424.5" "445.8" "416.4" "474.0" "469.9" "418.0" "404.4" "" "" "" "" "" "" "" "" "" "" "409.3" "348.4" "248.1" "309.5" "365.3" "323.4" "365.3" "404.1" "326.3" "363.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7607180034342260294" "False" "High" "IsMasterProtein" "Q6P179" "Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2" "0.000" "False" "33.535" "8" "8" "11" "8" "960" "110.4" "6.71" "34.35" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "64167" "ENSG00000164308" "ERAP2" "hsa:64167; Q6P179; Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "1.072" "1.004" "1.074" "1.025" "0.985" "1.012" "1.008" "1.010" "1.058" "623.7" "668.5" "626.1" "670.2" "639.2" "614.6" "631.2" "629.0" "629.9" "660.0" "" "" "" "" "" "" "" "" "" "" "623.7" "565.5" "395.9" "488.6" "523.7" "477.3" "486.5" "540.8" "491.7" "593.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "33.474" "7" "7" "10" "7" "1042" "112.1" "6.60" "23.72" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "MAPK cascade" "Rap1 signalling" "2" "0" "1.163" "1.029" "1.134" "1.117" "1.147" "1.115" "1.160" "1.081" "1.065" "453.9" "527.9" "467.1" "514.8" "507.2" "520.7" "506.2" "526.4" "490.5" "483.5" "" "" "" "" "" "" "" "" "" "" "453.9" "446.6" "295.3" "375.4" "415.5" "404.4" "390.2" "452.6" "382.9" "434.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "33.455" "35" "6" "10" "4" "162" "18.9" "8.44" "34.25" "6" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "2" "0.976" "0.932" "1.033" "1.037" "0.945" "1.057" "1.104" "0.940" "1.012" "812.9" "793.3" "757.7" "840.1" "842.7" "768.1" "859.6" "897.8" "763.8" "823.0" "" "" "" "" "" "" "" "" "" "" "812.9" "671.2" "479.1" "612.5" "690.4" "596.5" "662.6" "772.0" "596.2" "739.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "33.420" "9" "9" "11" "8" "1258" "138.5" "6.54" "33.25" "9" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "EGF/EGFR signaling pathway; Insulin signaling" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "6" "0" "1.070" "0.877" "0.971" "1.052" "0.866" "1.029" "1.051" "0.840" "0.902" "327.3" "350.2" "287.1" "317.7" "344.2" "283.4" "336.7" "343.9" "274.8" "295.1" "" "" "" "" "" "" "" "" "" "" "327.3" "296.3" "181.5" "231.7" "282.0" "220.1" "259.6" "295.7" "214.5" "265.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.000" "False" "33.416" "7" "9" "9" "9" "1478" "166.9" "4.92" "27.65" "9" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "Clock-controlled autophagy in bone metabolism" "" "1" "0" "1.032" "0.856" "1.066" "1.062" "0.749" "1.080" "1.045" "0.856" "0.946" "267.2" "275.6" "228.8" "284.8" "283.7" "200.1" "288.6" "279.2" "228.7" "252.6" "" "" "" "" "" "" "" "" "" "" "267.2" "233.2" "144.7" "207.7" "232.5" "155.4" "222.5" "240.0" "178.5" "227.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "33.406" "6" "7" "9" "7" "1136" "124.5" "6.10" "29.78" "7" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "" "Neutrophil degranulation; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "1.048" "0.966" "1.056" "1.058" "0.979" "1.058" "1.095" "1.002" "1.013" "544.5" "570.7" "526.2" "575.1" "575.8" "533.2" "576.3" "596.0" "545.4" "551.7" "" "" "" "" "" "" "" "" "" "" "544.5" "482.8" "332.7" "419.3" "471.8" "414.1" "444.2" "512.4" "425.7" "496.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "33.392" "19" "9" "13" "9" "486" "55.7" "5.20" "38.26" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "" "Clathrin-mediated endocytosis" "1" "0" "1.050" "1.169" "1.111" "1.091" "1.088" "1.090" "1.043" "1.131" "1.145" "424.6" "446.0" "496.2" "471.8" "463.1" "461.7" "463.0" "443.0" "480.0" "486.1" "" "" "" "" "" "" "" "" "" "" "424.6" "377.3" "313.7" "344.0" "379.4" "358.6" "356.9" "380.9" "374.7" "437.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "33.362" "21" "8" "18" "8" "332" "37.5" "7.87" "52.39" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "0.981" "1.046" "0.935" "0.931" "0.950" "0.869" "0.873" "1.007" "1.025" "1536.8" "1507.3" "1607.5" "1436.6" "1430.7" "1460.6" "1334.8" "1341.5" "1546.9" "1575.1" "" "" "" "" "" "" "" "" "" "" "1536.8" "1275.2" "1016.4" "1047.5" "1172.2" "1134.3" "1028.9" "1153.5" "1207.5" "1416.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "33.341" "12" "8" "10" "8" "736" "79.6" "8.84" "31.54" "8" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "10" "0" "1.087" "1.007" "1.016" "1.001" "1.064" "0.976" "1.031" "0.937" "0.945" "186.0" "202.2" "187.3" "189.0" "186.1" "197.8" "181.4" "191.8" "174.4" "175.7" "" "" "" "" "" "" "" "" "" "" "186.0" "171.1" "118.5" "137.8" "152.5" "153.6" "139.9" "164.9" "136.1" "158.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "33.270" "25" "8" "11" "8" "335" "37.7" "5.15" "37.41" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "13" "0" "1.007" "0.985" "1.136" "1.109" "1.035" "1.169" "1.055" "1.026" "1.012" "639.1" "643.7" "629.3" "725.9" "709.0" "661.3" "747.0" "674.5" "655.8" "646.9" "" "" "" "" "" "" "" "" "" "" "639.1" "544.6" "397.9" "529.3" "580.9" "513.5" "575.8" "580.0" "511.9" "581.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "33.265" "17" "9" "12" "9" "501" "54.1" "8.66" "36.14" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Amino acid metabolism" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "5" "0" "1.002" "0.981" "1.073" "0.978" "1.017" "0.998" "1.006" "0.848" "0.892" "379.6" "380.2" "372.4" "407.5" "371.4" "386.0" "378.7" "381.9" "321.9" "338.6" "" "" "" "" "" "" "" "" "" "" "379.6" "321.7" "235.5" "297.1" "304.3" "299.7" "291.9" "328.3" "251.3" "304.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "33.263" "21" "8" "8" "8" "457" "50.2" "8.31" "24.02" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.960" "0.994" "1.004" "0.998" "0.983" "0.974" "0.977" "0.985" "0.973" "541.2" "519.6" "538.1" "543.3" "540.0" "532.0" "527.4" "529.0" "533.3" "526.5" "" "" "" "" "" "" "" "" "" "" "541.2" "439.6" "340.2" "396.1" "442.4" "413.2" "406.5" "454.8" "416.3" "473.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "33.231" "18" "6" "10" "5" "364" "40.7" "8.88" "32.96" "6" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Protein hydroxylation" "2" "0" "1.012" "0.927" "1.063" "1.043" "1.017" "1.007" "1.025" "0.987" "1.024" "417.0" "421.8" "386.7" "443.3" "434.8" "423.9" "420.1" "427.4" "411.4" "427.1" "" "" "" "" "" "" "" "" "" "" "417.0" "356.9" "244.5" "323.3" "356.2" "329.2" "323.8" "367.4" "321.2" "384.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7470161461111362497" "False" "High" "IsMasterProtein" "Q7Z4S6" "Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2" "0.000" "False" "33.225" "6" "8" "10" "6" "1674" "187.1" "6.42" "34.88" "8" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "55605" "ENSG00000139116" "KIF21A" "A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219; hsa:55605; Q2UVF1; Q6UKL9; Q7Z4S6; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; Q9NXU4; Q9Y590" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "2" "1.002" "1.035" "1.111" "1.095" "1.078" "1.122" "1.148" "0.950" "1.018" "381.0" "382.0" "394.3" "423.5" "417.2" "410.8" "427.5" "437.3" "362.2" "388.0" "" "" "" "" "" "" "" "" "" "" "381.0" "323.1" "249.3" "308.8" "341.8" "319.0" "329.5" "376.0" "282.7" "348.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "33.207" "34" "8" "17" "2" "207" "23.7" "9.07" "52.98" "8" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "10" "2" "0.922" "1.042" "0.920" "0.946" "1.149" "0.881" "0.902" "1.127" "1.088" "353.0" "325.5" "367.7" "324.7" "334.0" "405.5" "310.8" "318.2" "397.7" "384.0" "" "" "" "" "" "" "" "" "" "" "353.0" "275.4" "232.5" "236.8" "273.6" "314.9" "239.6" "273.6" "310.4" "345.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "33.194" "35" "6" "10" "5" "206" "22.2" "9.38" "35.11" "6" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "Orexin receptor pathway" "" "1" "0" "1.039" "0.910" "1.091" "0.968" "0.814" "0.991" "0.980" "0.970" "0.879" "157.0" "163.2" "142.9" "171.3" "151.9" "127.8" "155.6" "153.9" "152.3" "138.0" "" "" "" "" "" "" "" "" "" "" "157.0" "138.0" "90.3" "124.9" "124.5" "99.2" "120.0" "132.3" "118.9" "124.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "33.189" "18" "5" "12" "5" "386" "43.2" "7.17" "37.29" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.158" "1.000" "1.070" "1.186" "1.000" "1.123" "1.152" "0.939" "1.038" "327.9" "379.8" "328.0" "350.8" "388.8" "327.9" "368.3" "377.8" "307.9" "340.3" "" "" "" "" "" "" "" "" "" "" "327.9" "321.3" "207.4" "255.8" "318.5" "254.6" "283.9" "324.8" "240.4" "306.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "33.122" "10" "8" "16" "8" "765" "90.7" "9.31" "42.97" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "Ebola virus infection in host; 15q25 copy number variation" "SUMOylation of DNA replication proteins" "3" "0" "1.050" "1.179" "1.040" "1.039" "1.147" "1.027" "1.060" "1.130" "0.991" "629.9" "661.5" "742.7" "655.3" "654.1" "722.5" "647.0" "667.9" "711.5" "624.1" "" "" "" "" "" "" "" "" "" "" "629.9" "559.7" "469.6" "477.8" "535.9" "561.1" "498.7" "574.2" "555.4" "561.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "33.119" "19" "6" "10" "6" "404" "43.4" "4.88" "32.36" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "1.150" "0.998" "1.129" "1.005" "0.992" "1.080" "1.081" "1.037" "1.086" "512.3" "589.0" "511.3" "578.5" "514.8" "508.3" "553.2" "553.9" "531.3" "556.1" "" "" "" "" "" "" "" "" "" "" "512.3" "498.3" "323.3" "421.8" "421.8" "394.8" "426.4" "476.2" "414.7" "500.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "33.102" "49" "6" "21" "6" "108" "12.8" "5.29" "68.73" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "VEGFA-VEGFR2 signaling" "Post-chaperonin tubulin folding pathway" "2" "0" "0.959" "1.047" "0.891" "0.996" "1.105" "1.168" "0.950" "1.067" "1.008" "1628.6" "1562.4" "1705.1" "1451.7" "1622.3" "1800.1" "1902.6" "1546.3" "1736.9" "1641.1" "" "" "" "" "" "" "" "" "" "" "1628.6" "1321.8" "1078.2" "1058.5" "1329.2" "1397.9" "1466.6" "1329.5" "1355.8" "1475.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "33.038" "23" "6" "10" "5" "327" "38.1" "6.57" "28.05" "6" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.139" "1.145" "1.128" "1.034" "1.170" "1.072" "1.110" "1.060" "1.043" "279.6" "318.4" "320.1" "315.3" "289.1" "327.1" "299.6" "310.4" "296.2" "291.5" "" "" "" "" "" "" "" "" "" "" "279.6" "269.4" "202.4" "229.9" "236.8" "254.0" "230.9" "266.9" "231.2" "262.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "33.026" "25" "5" "11" "5" "273" "28.9" "7.81" "40.92" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Proteasome degradation" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.982" "1.007" "0.971" "0.971" "1.059" "1.002" "0.988" "1.051" "1.066" "618.5" "607.2" "622.6" "600.7" "600.8" "655.2" "619.8" "610.9" "650.2" "659.4" "" "" "" "" "" "" "" "" "" "" "618.5" "513.7" "393.7" "438.0" "492.2" "508.8" "477.8" "525.3" "507.5" "592.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "33.016" "5" "7" "9" "7" "1436" "162.0" "5.50" "32.78" "7" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "35" "0" "1.033" "0.799" "0.988" "1.063" "0.859" "1.158" "1.139" "0.804" "0.977" "396.7" "409.7" "316.9" "391.7" "421.5" "340.8" "459.4" "452.0" "318.8" "387.7" "" "" "" "" "" "" "" "" "" "" "396.7" "346.6" "200.4" "285.6" "345.3" "264.7" "354.1" "388.6" "248.9" "348.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "32.835" "29" "7" "13" "7" "241" "27.5" "6.60" "40.09" "7" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "7" "0" "1.011" "1.019" "0.959" "0.959" "1.023" "0.938" "0.934" "1.035" "1.002" "723.7" "731.3" "737.7" "693.9" "693.7" "740.5" "679.2" "676.0" "748.8" "725.0" "" "" "" "" "" "" "" "" "" "" "723.7" "618.7" "466.4" "505.9" "568.4" "575.1" "523.5" "581.2" "584.5" "651.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "32.833" "22" "8" "15" "6" "363" "39.6" "4.58" "53.20" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "6" "0" "1.036" "1.073" "1.022" "1.076" "1.032" "1.031" "1.042" "1.067" "0.973" "299.4" "310.2" "321.3" "306.0" "322.1" "309.1" "308.7" "312.0" "319.3" "291.5" "" "" "" "" "" "" "" "" "" "" "299.4" "262.5" "203.2" "223.1" "263.9" "240.0" "238.0" "268.2" "249.3" "262.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "32.831" "11" "8" "8" "8" "881" "96.7" "4.55" "28.35" "8" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "" "COPII-mediated vesicle transport" "1" "0" "0.959" "0.833" "0.984" "1.061" "0.906" "0.961" "0.999" "0.781" "0.997" "273.4" "262.3" "227.7" "269.2" "290.3" "247.8" "262.8" "273.2" "213.7" "272.6" "" "" "" "" "" "" "" "" "" "" "273.4" "221.9" "144.0" "196.3" "237.8" "192.5" "202.6" "234.9" "166.8" "245.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "32.773" "20" "5" "9" "5" "305" "35.1" "5.69" "32.63" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.014" "0.893" "0.877" "0.970" "0.989" "0.872" "0.971" "0.860" "1.020" "195.7" "198.5" "174.8" "171.6" "189.7" "193.4" "170.5" "189.9" "168.3" "199.7" "" "" "" "" "" "" "" "" "" "" "195.7" "167.9" "110.5" "125.1" "155.4" "150.2" "131.5" "163.3" "131.4" "179.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "32.737" "45" "6" "17" "6" "118" "13.5" "9.91" "52.59" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA processing" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "5" "0" "1.046" "1.132" "1.024" "1.005" "1.065" "1.057" "1.022" "1.035" "0.944" "1107.6" "1158.9" "1253.5" "1134.2" "1112.9" "1179.9" "1170.4" "1131.9" "1146.0" "1046.0" "" "" "" "" "" "" "" "" "" "" "1107.6" "980.5" "792.6" "827.0" "911.8" "916.3" "902.2" "973.2" "894.5" "940.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "32.724" "16" "5" "7" "5" "331" "36.5" "4.79" "26.05" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "1.036" "1.072" "1.147" "1.128" "1.014" "1.155" "1.068" "1.125" "1.151" "399.1" "413.5" "427.7" "457.9" "450.0" "404.9" "460.9" "426.4" "449.1" "459.5" "" "" "" "" "" "" "" "" "" "" "399.1" "349.8" "270.4" "333.9" "368.7" "314.4" "355.3" "366.6" "350.5" "413.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "32.722" "17" "7" "8" "7" "504" "54.6" "5.52" "26.38" "7" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "0.925" "0.917" "1.065" "0.994" "0.930" "0.985" "1.002" "1.022" "1.061" "144.6" "133.8" "132.6" "154.1" "143.7" "134.5" "142.4" "144.9" "147.8" "153.5" "" "" "" "" "" "" "" "" "" "" "144.6" "113.2" "83.8" "112.3" "117.7" "104.5" "109.8" "124.6" "115.3" "138.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "32.628" "4" "11" "11" "11" "2209" "250.6" "5.97" "32.19" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.987" "1.079" "0.971" "0.964" "0.865" "0.961" "1.008" "0.885" "1.002" "166.9" "164.7" "180.0" "162.1" "160.9" "144.3" "160.4" "168.3" "147.7" "167.2" "" "" "" "" "" "" "" "" "" "" "166.9" "139.4" "113.8" "118.2" "131.8" "112.1" "123.7" "144.7" "115.3" "150.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "32.608" "14" "3" "30" "3" "111" "12.2" "3.78" "114.47" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.993" "0.770" "1.041" "1.053" "0.869" "1.216" "1.013" "0.804" "0.998" "3183.2" "3162.0" "2450.1" "3314.2" "3350.6" "2766.3" "3869.5" "3223.1" "2558.1" "3176.4" "" "" "" "" "" "" "" "" "" "" "3183.2" "2675.2" "1549.2" "2416.5" "2745.2" "2148.2" "2982.8" "2771.2" "1996.8" "2855.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "32.598" "33" "5" "9" "5" "179" "19.6" "7.37" "33.01" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Gastric cancer network 1; Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "21" "0" "0.947" "0.541" "0.938" "0.892" "0.492" "0.898" "0.920" "0.534" "0.806" "478.6" "453.1" "259.0" "448.8" "426.9" "235.3" "429.8" "440.3" "255.5" "385.8" "" "" "" "" "" "" "" "" "" "" "478.6" "383.3" "163.8" "327.3" "349.7" "182.7" "331.3" "378.6" "199.4" "346.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "32.592" "16" "6" "10" "6" "455" "52.5" "6.27" "24.85" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.841" "0.902" "0.836" "0.874" "0.921" "0.845" "0.895" "0.965" "0.976" "387.7" "326.2" "349.8" "323.9" "339.0" "357.2" "327.5" "347.0" "374.1" "378.2" "" "" "" "" "" "" "" "" "" "" "387.7" "276.0" "221.2" "236.2" "277.7" "277.4" "252.4" "298.4" "292.0" "340.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "32.569" "19" "10" "12" "10" "619" "68.5" "5.86" "38.75" "10" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells" "20" "0" "1.034" "0.946" "1.031" "1.045" "0.970" "1.016" "1.041" "0.893" "1.019" "402.0" "415.7" "380.2" "414.3" "420.2" "389.8" "408.6" "418.6" "359.1" "409.5" "" "" "" "" "" "" "" "" "" "" "402.0" "351.7" "240.4" "302.1" "344.3" "302.7" "314.9" "360.0" "280.3" "368.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "32.568" "34" "5" "9" "5" "234" "25.9" "7.43" "36.36" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; Neutrophil degranulation; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.921" "0.824" "0.905" "0.800" "0.904" "0.993" "0.880" "0.921" "1.017" "188.5" "173.7" "155.4" "170.6" "150.7" "170.4" "187.1" "165.8" "173.7" "191.8" "" "" "" "" "" "" "" "" "" "" "188.5" "146.9" "98.3" "124.4" "123.5" "132.3" "144.2" "142.6" "135.6" "172.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "32.556" "7" "9" "10" "9" "1243" "140.3" "8.22" "28.01" "9" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "0.978" "0.857" "1.126" "0.935" "0.863" "0.983" "1.014" "0.831" "0.966" "292.3" "285.8" "250.6" "329.1" "273.3" "252.2" "287.4" "296.4" "242.8" "282.4" "" "" "" "" "" "" "" "" "" "" "292.3" "241.8" "158.4" "240.0" "223.9" "195.9" "221.5" "254.8" "189.6" "253.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "32.520" "14" "8" "12" "8" "593" "65.2" "9.70" "34.16" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.014" "0.847" "1.033" "1.033" "0.924" "1.086" "1.055" "0.865" "0.952" "448.9" "455.1" "380.4" "463.9" "463.7" "415.0" "487.3" "473.6" "388.5" "427.2" "" "" "" "" "" "" "" "" "" "" "448.9" "385.0" "240.5" "338.3" "379.9" "322.3" "375.6" "407.2" "303.2" "384.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "32.514" "10" "8" "9" "8" "785" "87.1" "6.55" "30.69" "8" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.101" "0.824" "0.865" "0.983" "0.802" "1.018" "1.018" "0.881" "0.849" "403.8" "444.4" "332.6" "349.2" "396.7" "323.9" "411.0" "410.9" "355.9" "342.7" "" "" "" "" "" "" "" "" "" "" "403.8" "376.0" "210.3" "254.6" "325.0" "251.6" "316.8" "353.3" "277.8" "308.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "32.473" "16" "7" "11" "7" "504" "55.1" "6.61" "38.88" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "" "mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex" "5" "0" "0.995" "1.146" "0.982" "0.994" "1.084" "0.956" "1.004" "1.081" "0.938" "714.3" "710.5" "818.8" "701.6" "710.2" "774.3" "683.1" "716.9" "772.0" "670.2" "" "" "" "" "" "" "" "" "" "" "714.3" "601.1" "517.7" "511.5" "581.8" "601.3" "526.6" "616.4" "602.6" "602.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "32.466" "6" "9" "10" "9" "1358" "153.0" "7.17" "29.99" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI3K Cascade; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "25" "0" "1.071" "0.983" "1.033" "1.068" "1.004" "1.031" "1.104" "0.890" "0.998" "421.1" "451.1" "413.9" "435.1" "449.6" "422.6" "434.1" "465.0" "374.5" "420.2" "" "" "" "" "" "" "" "" "" "" "421.1" "381.7" "261.7" "317.2" "368.4" "328.2" "334.7" "399.8" "292.4" "377.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "32.431" "11" "10" "10" "10" "780" "90.9" "7.94" "31.53" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Downregulation of ERBB2 signaling; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "10" "0" "1.083" "1.056" "1.093" "1.087" "1.176" "1.079" "1.008" "1.056" "1.115" "387.1" "419.2" "408.8" "423.1" "421.0" "455.4" "417.6" "390.1" "409.0" "431.8" "" "" "" "" "" "" "" "" "" "" "387.1" "354.6" "258.5" "308.5" "344.9" "353.7" "321.9" "335.4" "319.2" "388.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "32.368" "15" "7" "13" "4" "557" "59.6" "9.16" "46.38" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "1" "0.976" "1.060" "0.996" "0.924" "1.070" "1.016" "0.928" "1.127" "0.912" "785.2" "766.4" "832.6" "782.4" "725.3" "840.2" "798.0" "728.6" "885.0" "716.1" "" "" "" "" "" "" "" "" "" "" "785.2" "648.4" "526.4" "570.5" "594.3" "652.5" "615.1" "626.4" "690.8" "643.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "32.363" "11" "6" "9" "6" "721" "80.3" "5.08" "31.90" "6" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "1.085" "1.021" "1.064" "1.045" "1.025" "1.033" "1.051" "1.032" "1.044" "458.5" "497.6" "468.1" "487.7" "479.3" "469.8" "473.8" "482.0" "473.1" "478.5" "" "" "" "" "" "" "" "" "" "" "458.5" "421.0" "296.0" "355.6" "392.7" "364.9" "365.3" "414.4" "369.3" "430.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "32.361" "30" "3" "7" "3" "128" "14.8" "9.19" "25.42" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.049" "1.345" "1.113" "1.208" "1.702" "1.226" "1.321" "1.639" "1.193" "227.0" "238.2" "305.4" "252.7" "274.4" "386.5" "278.4" "300.0" "372.1" "270.9" "" "" "" "" "" "" "" "" "" "" "227.0" "201.5" "193.1" "184.2" "224.8" "300.2" "214.6" "258.0" "290.4" "243.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "32.331" "22" "4" "16" "4" "214" "22.1" "8.70" "49.08" "4" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "Selenium micronutrient network" "" "1" "0" "1.030" "0.932" "1.017" "1.066" "0.988" "1.008" "1.011" "1.028" "1.044" "604.4" "622.8" "563.1" "614.4" "644.1" "597.3" "609.5" "611.2" "621.1" "631.0" "" "" "" "" "" "" "" "" "" "" "604.4" "526.9" "356.1" "448.0" "527.7" "463.9" "469.9" "525.5" "484.8" "567.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "32.288" "7" "6" "8" "5" "1037" "111.0" "5.03" "27.33" "6" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "29" "1" "0.993" "0.999" "1.064" "0.918" "0.947" "0.979" "0.994" "1.005" "1.046" "605.6" "601.3" "604.7" "644.6" "555.9" "573.4" "592.6" "602.1" "608.6" "633.3" "" "" "" "" "" "" "" "" "" "" "605.6" "508.7" "382.4" "470.0" "455.5" "445.3" "456.8" "517.7" "475.1" "569.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "32.281" "12" "6" "8" "6" "576" "60.3" "4.83" "29.25" "6" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "5" "0" "1.017" "1.086" "1.037" "1.113" "1.062" "1.029" "1.035" "1.178" "1.062" "265.0" "269.4" "287.9" "274.9" "295.1" "281.4" "272.8" "274.3" "312.1" "281.5" "" "" "" "" "" "" "" "" "" "" "265.0" "227.9" "182.1" "200.5" "241.8" "218.6" "210.3" "235.9" "243.6" "253.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "32.279" "11" "6" "11" "6" "639" "68.3" "8.98" "37.50" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.022" "1.124" "1.022" "1.091" "1.057" "1.169" "1.073" "0.969" "0.983" "642.8" "657.1" "722.3" "657.0" "701.3" "679.8" "751.5" "689.7" "622.8" "632.0" "" "" "" "" "" "" "" "" "" "" "642.8" "555.9" "456.7" "479.1" "574.6" "527.9" "579.3" "593.0" "486.1" "568.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "32.252" "39" "5" "12" "5" "132" "14.5" "7.21" "41.36" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.959" "1.229" "0.978" "1.004" "1.294" "1.084" "1.074" "1.268" "1.073" "982.9" "942.7" "1207.9" "961.4" "987.1" "1271.7" "1065.9" "1055.6" "1245.9" "1054.8" "" "" "" "" "" "" "" "" "" "" "982.9" "797.6" "763.8" "701.0" "808.7" "987.6" "821.6" "907.6" "972.5" "948.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "32.248" "14" "8" "12" "8" "508" "56.9" "8.15" "35.84" "8" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "5" "0" "1.001" "1.055" "0.994" "0.959" "0.994" "0.947" "0.945" "1.055" "1.014" "959.5" "960.9" "1012.6" "953.4" "920.6" "953.6" "908.6" "906.7" "1012.2" "972.6" "" "" "" "" "" "" "" "" "" "" "959.5" "812.9" "640.3" "695.2" "754.3" "740.5" "700.4" "779.6" "790.0" "874.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "32.185" "17" "7" "8" "4" "521" "57.9" "4.96" "29.49" "7" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "Leptin signaling pathway" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "3" "0" "0.944" "1.149" "1.331" "1.082" "1.335" "1.102" "1.069" "1.126" "1.119" "104.0" "98.1" "119.5" "138.4" "112.5" "138.8" "114.5" "111.1" "117.1" "116.4" "" "" "" "" "" "" "" "" "" "" "104.0" "83.0" "75.6" "100.9" "92.2" "107.8" "88.3" "95.6" "91.4" "104.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "32.177" "17" "6" "12" "6" "391" "45.1" "7.74" "38.47" "6" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "22" "0" "1.009" "1.022" "1.041" "1.063" "1.019" "1.032" "1.062" "1.034" "1.063" "701.5" "707.8" "717.1" "730.0" "745.5" "715.0" "723.9" "745.0" "725.5" "745.8" "" "" "" "" "" "" "" "" "" "" "701.5" "598.8" "453.4" "532.3" "610.8" "555.2" "558.0" "640.6" "566.3" "670.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "32.141" "19" "6" "12" "6" "359" "39.3" "5.21" "42.22" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "1.013" "0.938" "1.032" "0.962" "0.823" "0.921" "0.963" "0.939" "0.930" "489.0" "495.4" "458.5" "504.6" "470.3" "402.4" "450.4" "471.1" "459.2" "454.5" "" "" "" "" "" "" "" "" "" "" "489.0" "419.1" "289.9" "368.0" "385.3" "312.5" "347.2" "405.0" "358.4" "408.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "32.131" "5" "6" "11" "6" "1137" "127.3" "8.02" "35.44" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "5" "0" "1.030" "0.957" "1.123" "1.080" "0.966" "1.159" "1.153" "1.018" "0.977" "360.3" "371.1" "344.9" "404.7" "389.0" "348.0" "417.6" "415.6" "366.9" "352.1" "" "" "" "" "" "" "" "" "" "" "360.3" "313.9" "218.1" "295.1" "318.7" "270.2" "321.9" "357.3" "286.4" "316.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "32.126" "20" "9" "10" "9" "507" "57.0" "6.37" "26.88" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "1.168" "0.954" "1.063" "1.063" "0.813" "0.885" "0.935" "0.968" "1.143" "154.5" "180.5" "147.4" "164.2" "164.2" "125.5" "136.6" "144.4" "149.5" "176.6" "" "" "" "" "" "" "" "" "" "" "154.5" "152.7" "93.2" "119.7" "134.5" "97.5" "105.3" "124.1" "116.7" "158.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "32.123" "12" "9" "13" "9" "808" "89.6" "6.30" "40.45" "9" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "0.996" "0.969" "0.991" "0.994" "0.970" "1.018" "1.019" "0.930" "0.983" "591.3" "588.9" "573.2" "585.8" "587.8" "573.6" "602.2" "602.6" "550.1" "581.4" "" "" "" "" "" "" "" "" "" "" "591.3" "498.2" "362.5" "427.1" "481.6" "445.5" "464.2" "518.1" "429.4" "522.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "32.072" "16" "11" "13" "11" "795" "88.9" "6.54" "30.52" "11" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "1.108" "0.965" "0.968" "1.094" "0.975" "1.014" "1.135" "1.089" "1.006" "207.4" "229.7" "200.1" "200.8" "226.8" "202.2" "210.4" "235.5" "225.9" "208.6" "" "" "" "" "" "" "" "" "" "" "207.4" "194.4" "126.5" "146.4" "185.8" "157.1" "162.2" "202.5" "176.4" "187.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "32.071" "14" "8" "13" "8" "586" "65.4" "8.97" "42.83" "8" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "0.992" "1.066" "0.983" "1.003" "1.081" "1.050" "1.032" "1.063" "0.946" "916.7" "909.4" "977.1" "901.4" "918.9" "990.6" "962.8" "945.8" "974.6" "866.9" "" "" "" "" "" "" "" "" "" "" "916.7" "769.4" "617.8" "657.3" "752.9" "769.2" "742.2" "813.2" "760.7" "779.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "32.051" "10" "5" "7" "5" "532" "57.8" "7.99" "25.13" "5" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "27" "0" "1.066" "1.141" "0.939" "1.070" "1.095" "0.965" "1.036" "1.058" "1.023" "183.0" "195.2" "208.7" "171.8" "195.9" "200.4" "176.7" "189.6" "193.7" "187.3" "" "" "" "" "" "" "" "" "" "" "183.0" "165.1" "132.0" "125.3" "160.5" "155.6" "136.2" "163.0" "151.2" "168.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "32.046" "9" "7" "8" "7" "824" "91.8" "7.02" "30.42" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Cell cycle; 2q21.1 copy number variation syndrome" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.031" "0.827" "1.012" "1.065" "0.877" "1.033" "1.038" "0.808" "0.938" "476.7" "491.5" "394.4" "482.5" "507.4" "418.1" "492.5" "495.0" "385.2" "447.2" "" "" "" "" "" "" "" "" "" "" "476.7" "415.8" "249.4" "351.8" "415.7" "324.7" "379.6" "425.6" "300.7" "402.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "High" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.000" "False" "32.025" "10" "8" "9" "7" "767" "88.8" "6.98" "28.94" "8" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "" "Neutrophil degranulation; Purine salvage" "2" "0" "1.052" "1.029" "1.091" "1.026" "1.018" "1.064" "1.055" "1.048" "1.021" "483.4" "508.6" "497.6" "527.5" "496.0" "492.3" "514.4" "510.0" "506.5" "493.8" "" "" "" "" "" "" "" "" "" "" "483.4" "430.3" "314.6" "384.6" "406.4" "382.3" "396.5" "438.5" "395.4" "444.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "31.989" "13" "8" "14" "8" "630" "70.9" "8.09" "42.92" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "Termination of translesion DNA synthesis; ISG15 antiviral mechanism; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "19" "0" "1.054" "0.948" "0.962" "1.053" "1.025" "1.052" "1.075" "1.015" "1.104" "783.4" "826.0" "742.7" "753.5" "824.5" "802.6" "824.2" "841.8" "794.9" "865.1" "" "" "" "" "" "" "" "" "" "" "783.4" "698.8" "469.6" "549.4" "675.5" "623.3" "635.3" "723.8" "620.5" "777.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "31.987" "31" "7" "11" "7" "217" "24.3" "8.12" "38.71" "7" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "" "Mitochondrial protein import" "1" "0" "0.962" "1.048" "0.868" "0.965" "1.032" "0.962" "0.932" "1.023" "0.979" "728.4" "700.6" "763.1" "632.0" "702.8" "752.0" "700.8" "678.8" "745.3" "713.1" "" "" "" "" "" "" "" "" "" "" "728.4" "592.7" "482.5" "460.8" "575.8" "584.0" "540.2" "583.6" "581.7" "641.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "31.964" "20" "8" "10" "6" "392" "46.5" "10.01" "30.40" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "2" "1.022" "1.117" "1.061" "1.114" "1.143" "1.103" "1.098" "1.075" "1.017" "434.6" "443.9" "485.4" "461.3" "484.0" "496.9" "479.5" "477.3" "467.3" "441.8" "" "" "" "" "" "" "" "" "" "" "434.6" "375.6" "306.9" "336.4" "396.5" "385.9" "369.6" "410.4" "364.8" "397.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8814237146634600983" "False" "High" "IsMasterProtein" "Q15642" "Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3" "0.000" "False" "31.922" "15" "8" "11" "8" "601" "68.3" "5.73" "30.46" "8" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "9322" "ENSG00000125733" "TRIP10" "B2R8A6; B7WP22; D6W645; hsa:9322; O15184; Q15642; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1" "Angiopoietin-like protein 8 regulatory pathway" "RHOQ GTPase cycle; Clathrin-mediated endocytosis" "3" "0" "1.004" "1.176" "1.189" "1.070" "1.148" "1.083" "1.120" "1.178" "1.104" "914.4" "918.0" "1075.5" "1086.8" "978.6" "1049.4" "990.5" "1024.5" "1077.6" "1009.4" "" "" "" "" "" "" "" "" "" "" "914.4" "776.7" "680.0" "792.5" "801.8" "814.9" "763.5" "880.9" "841.1" "907.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3896694547723499941" "False" "High" "IsMasterProtein" "P19878" "Neutrophil cytosol factor 2 OS=Homo sapiens OX=9606 GN=NCF2 PE=1 SV=2" "0.000" "False" "31.920" "16" "8" "10" "8" "526" "59.7" "6.16" "28.74" "8" "other metabolic processes;stress response;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf13181" "4688" "ENSG00000116701" "NCF2" "B2R6Q1; B4DKQ7; B4DQA7; E9PHJ2; E9PHX3; hsa:4688; P19878; Q2PP06; Q8NFC7; Q9BV51" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia; IL-18 signaling pathway; p53 transcriptional gene network; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "16" "0" "1.045" "0.795" "1.004" "1.011" "0.954" "0.991" "0.939" "0.899" "0.942" "290.9" "304.1" "231.4" "292.0" "294.0" "277.6" "288.4" "273.1" "261.6" "274.1" "" "" "" "" "" "" "" "" "" "" "290.9" "257.3" "146.3" "212.9" "240.9" "215.6" "222.3" "234.8" "204.2" "246.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "31.917" "13" "7" "9" "7" "710" "81.4" "8.05" "26.48" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.080" "0.906" "1.062" "1.103" "0.998" "1.093" "0.970" "1.021" "1.084" "192.0" "207.5" "174.0" "203.9" "211.7" "191.6" "209.9" "186.2" "196.2" "208.1" "" "" "" "" "" "" "" "" "" "" "192.0" "175.5" "110.0" "148.7" "173.5" "148.8" "161.8" "160.1" "153.1" "187.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "31.916" "29" "4" "8" "4" "156" "17.9" "5.08" "29.86" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "0.935" "0.899" "0.971" "0.989" "0.991" "0.972" "0.983" "0.955" "1.023" "282.4" "264.0" "253.9" "274.2" "279.3" "279.8" "274.5" "277.5" "269.7" "289.0" "" "" "" "" "" "" "" "" "" "" "282.4" "223.3" "160.5" "199.9" "228.8" "217.3" "211.6" "238.6" "210.5" "259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "31.912" "24" "6" "13" "6" "276" "30.3" "7.43" "52.20" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Proteasome degradation; Immune response to tuberculosis" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "62" "0" "0.844" "1.040" "1.094" "0.975" "1.088" "1.018" "0.873" "1.129" "1.066" "369.8" "312.2" "384.8" "404.6" "360.5" "402.2" "376.7" "322.9" "417.7" "394.3" "" "" "" "" "" "" "" "" "" "" "369.8" "264.1" "243.3" "295.0" "295.4" "312.3" "290.3" "277.6" "326.0" "354.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "31.892" "23" "7" "9" "7" "299" "33.6" "4.81" "29.92" "7" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "1.083" "0.931" "1.062" "1.074" "0.944" "1.083" "1.074" "0.929" "1.013" "513.9" "556.5" "478.5" "545.7" "551.8" "485.2" "556.7" "552.1" "477.6" "520.6" "" "" "" "" "" "" "" "" "" "" "513.9" "470.8" "302.6" "397.9" "452.1" "376.8" "429.1" "474.7" "372.8" "468.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "31.864" "39" "5" "14" "5" "148" "17.2" "9.60" "49.21" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "2" "0" "0.912" "1.150" "0.845" "0.913" "1.131" "1.014" "1.009" "0.994" "1.061" "987.8" "901.0" "1135.6" "835.0" "901.5" "1117.4" "1001.8" "996.6" "981.8" "1048.1" "" "" "" "" "" "" "" "" "" "" "987.8" "762.2" "718.0" "608.9" "738.6" "867.7" "772.2" "856.9" "766.4" "942.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "31.849" "15" "6" "22" "2" "417" "44.8" "8.54" "74.24" "6" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "6" "0" "0.878" "1.053" "0.808" "0.885" "1.012" "0.823" "0.870" "1.057" "0.979" "607.4" "533.0" "639.5" "490.6" "537.8" "614.9" "500.0" "528.7" "641.8" "594.9" "" "" "" "" "" "" "" "" "" "" "607.4" "451.0" "404.4" "357.7" "440.6" "477.5" "385.4" "454.6" "501.0" "534.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "31.801" "29" "5" "16" "5" "241" "26.4" "4.79" "48.23" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Downstream TCR signaling; UCH proteinases; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.963" "1.052" "0.992" "0.983" "0.991" "0.957" "1.001" "1.018" "0.993" "1001.2" "964.3" "1053.6" "993.6" "984.4" "992.5" "958.3" "1002.5" "1019.4" "994.7" "" "" "" "" "" "" "" "" "" "" "1001.2" "815.8" "666.2" "724.4" "806.5" "770.8" "738.7" "862.0" "795.7" "894.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "31.799" "7" "9" "10" "9" "1357" "156.2" "5.64" "33.83" "9" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "11" "0" "1.045" "1.839" "1.113" "1.112" "2.016" "1.054" "1.108" "1.935" "1.385" "635.1" "663.6" "1167.9" "706.8" "706.0" "1280.5" "669.7" "703.6" "1229.0" "879.4" "" "" "" "" "" "" "" "" "" "" "635.1" "561.4" "738.5" "515.3" "578.4" "994.4" "516.2" "604.9" "959.3" "790.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2333660704476735765" "False" "High" "IsMasterProtein" "O15397" "Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2" "0.000" "False" "31.784" "7" "6" "9" "6" "1037" "119.9" "5.16" "26.06" "6" "transport;signal transduction" "cytosol;nucleus" "other molecular function" "Pf03810, Pf08506" "10526" "ENSG00000133704" "IPO8" "B7Z7M3; hsa:10526; O15397" "Autophagy in pancreatic ductal adenocarcinoma" "Transcriptional regulation by small RNAs" "2" "0" "1.088" "0.937" "1.067" "1.033" "0.904" "1.091" "1.110" "0.897" "1.058" "209.2" "227.6" "195.9" "223.3" "216.2" "189.1" "228.2" "232.1" "187.7" "221.3" "" "" "" "" "" "" "" "" "" "" "209.2" "192.6" "123.9" "162.8" "177.1" "146.9" "175.9" "199.6" "146.5" "198.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "31.764" "12" "4" "5" "4" "439" "48.9" "5.29" "20.99" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.974" "1.000" "0.896" "1.121" "1.102" "1.068" "1.014" "1.045" "1.045" "184.2" "179.3" "184.2" "165.0" "206.5" "203.0" "196.6" "186.7" "192.5" "192.4" "" "" "" "" "" "" "" "" "" "" "184.2" "151.7" "116.5" "120.3" "169.2" "157.6" "151.6" "160.5" "150.2" "173.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "31.762" "10" "8" "8" "8" "913" "101.3" "5.45" "27.31" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "Ectoderm differentiation" "" "1" "0" "1.030" "0.812" "1.093" "1.079" "1.066" "1.064" "1.060" "0.977" "1.053" "121.1" "124.8" "98.4" "132.4" "130.7" "129.1" "128.9" "128.4" "118.3" "127.6" "" "" "" "" "" "" "" "" "" "" "121.1" "105.6" "62.2" "96.6" "107.1" "100.3" "99.4" "110.4" "92.4" "114.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "31.740" "9" "7" "9" "7" "788" "86.7" "5.38" "26.14" "7" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "1.013" "0.880" "1.078" "1.044" "1.008" "1.018" "1.017" "0.877" "0.970" "389.8" "394.8" "342.9" "420.0" "406.8" "392.9" "397.0" "396.6" "341.9" "378.0" "" "" "" "" "" "" "" "" "" "" "389.8" "334.0" "216.8" "306.2" "333.3" "305.1" "306.0" "341.0" "266.8" "339.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "31.662" "16" "4" "11" "4" "380" "41.6" "5.27" "37.92" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.930" "1.001" "1.039" "1.120" "1.074" "1.139" "1.051" "1.037" "1.121" "317.6" "295.2" "317.9" "330.1" "355.8" "341.0" "361.8" "333.7" "329.4" "356.1" "" "" "" "" "" "" "" "" "" "" "317.6" "249.8" "201.0" "240.7" "291.5" "264.8" "278.9" "287.0" "257.1" "320.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "31.627" "12" "9" "9" "9" "810" "89.1" "8.37" "28.00" "9" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.944" "1.180" "0.969" "0.876" "1.082" "0.897" "0.859" "1.128" "0.992" "162.5" "153.5" "191.7" "157.5" "142.4" "175.8" "145.8" "139.6" "183.3" "161.3" "" "" "" "" "" "" "" "" "" "" "162.5" "129.9" "121.2" "114.9" "116.7" "136.5" "112.4" "120.1" "143.1" "145.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "31.625" "5" "9" "9" "9" "1593" "182.7" "8.44" "30.42" "9" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.123" "0.978" "1.066" "1.137" "1.054" "1.041" "1.069" "1.009" "1.069" "598.1" "671.8" "584.9" "637.7" "679.9" "630.3" "622.6" "639.6" "603.7" "639.2" "" "" "" "" "" "" "" "" "" "" "598.1" "568.4" "369.8" "465.0" "557.1" "489.5" "479.9" "550.0" "471.2" "574.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "31.605" "10" "5" "8" "5" "709" "81.0" "6.87" "27.97" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "1.083" "1.593" "0.959" "1.063" "1.630" "1.040" "0.908" "1.420" "1.172" "203.2" "220.1" "323.7" "194.8" "216.1" "331.1" "211.3" "184.4" "288.5" "238.1" "" "" "" "" "" "" "" "" "" "" "203.2" "186.2" "204.7" "142.0" "177.0" "257.1" "162.9" "158.6" "225.2" "214.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "31.600" "16" "8" "12" "8" "494" "53.8" "5.87" "34.60" "8" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "Carnitine synthesis" "4" "0" "0.975" "1.075" "1.007" "0.965" "1.015" "0.964" "0.982" "0.989" "1.008" "820.3" "800.1" "881.9" "826.4" "791.9" "832.6" "790.4" "805.2" "811.6" "826.7" "" "" "" "" "" "" "" "" "" "" "820.3" "676.9" "557.6" "602.5" "648.8" "646.5" "609.3" "692.3" "633.5" "743.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "31.577" "13" "8" "9" "8" "593" "68.0" "7.30" "28.19" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "91" "0" "1.039" "1.325" "1.073" "1.021" "1.257" "0.974" "1.027" "1.309" "1.132" "357.9" "371.7" "474.2" "384.1" "365.4" "449.8" "348.5" "367.4" "468.6" "405.2" "" "" "" "" "" "" "" "" "" "" "357.9" "314.5" "299.8" "280.1" "299.4" "349.3" "268.6" "315.9" "365.8" "364.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "31.576" "16" "8" "13" "8" "598" "65.9" "5.24" "44.54" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "0.865" "0.747" "0.978" "0.933" "0.762" "0.943" "0.946" "0.788" "0.908" "545.7" "471.9" "407.4" "533.7" "509.1" "415.7" "514.4" "516.4" "430.1" "495.7" "" "" "" "" "" "" "" "" "" "" "545.7" "399.3" "257.6" "389.2" "417.1" "322.8" "396.5" "444.0" "335.7" "445.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "31.508" "29" "6" "10" "6" "217" "25.2" "6.32" "35.27" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "73" "0" "0.941" "0.978" "0.913" "0.931" "0.936" "0.972" "0.960" "0.921" "0.970" "1101.6" "1037.1" "1077.8" "1005.8" "1025.6" "1031.4" "1070.3" "1057.6" "1014.8" "1068.4" "" "" "" "" "" "" "" "" "" "" "1101.6" "877.4" "681.5" "733.3" "840.3" "800.9" "825.0" "909.3" "792.1" "960.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "31.492" "11" "7" "9" "7" "597" "66.8" "5.39" "30.52" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "" "Neddylation" "1" "0" "0.977" "0.873" "0.988" "0.983" "0.903" "0.965" "1.021" "0.887" "0.942" "769.9" "752.4" "672.0" "760.9" "756.7" "695.0" "742.6" "785.7" "682.6" "725.5" "" "" "" "" "" "" "" "" "" "" "769.9" "636.5" "424.9" "554.8" "620.0" "539.8" "572.5" "675.6" "532.8" "652.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "31.489" "11" "7" "7" "7" "737" "83.7" "6.18" "26.08" "7" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "12" "0" "1.123" "1.039" "1.012" "1.172" "1.089" "1.132" "1.122" "1.020" "1.090" "346.9" "389.4" "360.4" "350.9" "406.7" "377.9" "392.5" "389.2" "353.6" "378.0" "" "" "" "" "" "" "" "" "" "" "346.9" "329.4" "227.9" "255.9" "333.2" "293.5" "302.6" "334.6" "276.0" "339.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5418508312129097166" "False" "High" "IsMasterProtein" "P35626" "G protein-coupled receptor kinase 3 OS=Homo sapiens OX=9606 GN=GRK3 PE=1 SV=2" "0.000" "False" "31.471" "11" "7" "11" "2" "688" "79.7" "7.62" "34.87" "7" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "157" "ENSG00000100077" "GRK3" "hsa:157; P35626; Q9UGW9" "Corticotropin-releasing hormone signaling pathway; Hedgehog signaling pathway" "G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis" "4" "0" "1.163" "0.782" "1.195" "1.247" "0.928" "1.169" "1.189" "1.011" "1.040" "46.8" "54.4" "36.6" "55.9" "58.3" "43.4" "54.7" "55.6" "47.3" "48.6" "" "" "" "" "" "" "" "" "" "" "46.8" "46.0" "23.1" "40.8" "47.8" "33.7" "42.2" "47.8" "36.9" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "31.469" "26" "4" "7" "4" "205" "23.0" "4.74" "32.63" "4" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "0.878" "1.115" "0.937" "0.902" "1.192" "1.072" "0.885" "1.139" "1.036" "372.8" "327.2" "415.6" "349.3" "336.1" "444.4" "399.5" "329.8" "424.7" "386.2" "" "" "" "" "" "" "" "" "" "" "372.8" "276.9" "262.8" "254.7" "275.3" "345.1" "308.0" "283.5" "331.5" "347.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "31.402" "6" "9" "10" "8" "1485" "171.2" "6.37" "30.33" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "1.054" "0.938" "1.029" "1.016" "0.967" "1.030" "1.050" "0.968" "1.057" "421.1" "443.6" "394.9" "433.1" "427.9" "407.3" "433.9" "441.9" "407.8" "445.2" "" "" "" "" "" "" "" "" "" "" "421.1" "375.3" "249.7" "315.8" "350.6" "316.3" "334.5" "380.0" "318.3" "400.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "31.353" "18" "8" "9" "8" "466" "51.4" "9.35" "28.61" "8" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "26" "0" "1.016" "0.820" "1.000" "1.035" "0.819" "1.014" "1.031" "0.832" "0.928" "833.1" "846.8" "683.4" "832.7" "862.3" "682.2" "845.1" "858.6" "693.2" "773.2" "" "" "" "" "" "" "" "" "" "" "833.1" "716.4" "432.1" "607.1" "706.5" "529.8" "651.5" "738.3" "541.1" "695.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "31.337" "19" "8" "14" "7" "316" "35.8" "6.98" "38.77" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "Pregnenolone biosynthesis; Fructose biosynthesis" "7" "0" "1.022" "1.099" "1.056" "1.008" "1.150" "1.002" "1.027" "1.119" "1.194" "773.5" "790.5" "849.8" "816.6" "779.6" "889.1" "774.6" "794.7" "865.7" "923.5" "" "" "" "" "" "" "" "" "" "" "773.5" "668.8" "537.3" "595.4" "638.8" "690.5" "597.1" "683.2" "675.7" "830.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "31.311" "8" "10" "11" "10" "1461" "155.9" "7.42" "32.65" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.957" "0.970" "1.155" "1.257" "0.883" "1.132" "1.187" "1.010" "1.018" "176.9" "169.3" "171.5" "204.3" "222.4" "156.2" "200.2" "210.0" "178.6" "180.1" "" "" "" "" "" "" "" "" "" "" "176.9" "143.2" "108.5" "149.0" "182.2" "121.3" "154.3" "180.6" "139.4" "161.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740935786864817136" "False" "High" "IsMasterProtein" "Q9BRX2" "Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2" "0.000" "False" "31.311" "15" "5" "7" "5" "385" "43.3" "6.34" "26.99" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "Pf03463, Pf03464, Pf03465" "53918" "ENSG00000152684" "PELO" "hsa:53918; Q9BRX2; Q9GZS6; Q9Y306" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "" "1" "0" "1.106" "0.881" "1.074" "1.105" "0.881" "1.070" "1.059" "0.875" "1.021" "453.9" "502.0" "399.8" "487.4" "501.6" "399.7" "485.4" "480.9" "396.9" "463.5" "" "" "" "" "" "" "" "" "" "" "453.9" "424.7" "252.8" "355.4" "411.0" "310.4" "374.2" "413.4" "309.8" "416.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "31.280" "7" "6" "9" "6" "957" "108.7" "7.56" "33.24" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.997" "0.940" "0.931" "1.005" "0.986" "1.021" "1.018" "0.910" "0.956" "892.9" "890.5" "839.0" "830.9" "897.1" "880.1" "911.3" "909.0" "812.6" "853.4" "" "" "" "" "" "" "" "" "" "" "892.9" "753.4" "530.5" "605.8" "735.0" "683.5" "702.4" "781.5" "634.2" "767.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "31.277" "35" "5" "21" "1" "152" "17.1" "6.57" "58.26" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "28" "0" "1.070" "1.130" "1.218" "0.996" "0.986" "1.170" "0.948" "0.785" "0.973" "54.6" "58.4" "61.6" "66.4" "54.3" "53.8" "63.9" "51.7" "42.8" "53.1" "" "" "" "" "" "" "" "" "" "" "54.6" "49.4" "39.0" "48.4" "44.5" "41.8" "49.2" "44.5" "33.4" "47.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "31.268" "17" "6" "10" "6" "470" "52.9" "7.46" "31.65" "6" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "1.033" "0.813" "1.106" "1.086" "0.834" "1.015" "0.970" "0.910" "1.020" "319.1" "329.5" "259.5" "352.8" "346.4" "266.2" "323.9" "309.5" "290.4" "325.5" "" "" "" "" "" "" "" "" "" "" "319.1" "278.7" "164.1" "257.2" "283.8" "206.7" "249.7" "266.1" "226.6" "292.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "31.243" "25" "4" "7" "4" "227" "26.0" "7.91" "28.58" "4" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "0.940" "0.910" "1.065" "1.043" "1.041" "1.143" "0.997" "0.963" "0.982" "426.8" "401.3" "388.2" "454.6" "445.1" "444.2" "487.8" "425.4" "410.9" "418.9" "" "" "" "" "" "" "" "" "" "" "426.8" "339.5" "245.5" "331.4" "364.7" "345.0" "376.0" "365.8" "320.8" "376.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.000" "False" "31.213" "15" "10" "10" "10" "725" "81.7" "5.49" "28.88" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "RalA downstream regulated genes; Ciliary landscape" "Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane; VxPx cargo-targeting to cilium" "5" "0" "1.043" "0.837" "1.122" "1.058" "0.853" "1.099" "1.105" "0.892" "0.976" "272.5" "284.4" "228.0" "305.8" "288.5" "232.3" "299.4" "301.1" "243.1" "265.9" "" "" "" "" "" "" "" "" "" "" "272.5" "240.6" "144.2" "222.9" "236.3" "180.4" "230.8" "258.9" "189.7" "239.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "31.159" "16" "6" "8" "6" "421" "46.6" "8.37" "27.26" "6" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "13" "0" "1.085" "0.994" "0.986" "1.053" "1.080" "0.978" "1.060" "0.994" "1.072" "610.1" "661.7" "606.7" "601.7" "642.3" "658.9" "596.7" "646.8" "606.5" "654.0" "" "" "" "" "" "" "" "" "" "" "610.1" "559.8" "383.6" "438.7" "526.2" "511.7" "460.0" "556.1" "473.4" "587.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "31.148" "36" "8" "10" "8" "211" "24.2" "11.65" "31.69" "8" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.973" "1.441" "1.110" "1.139" "1.527" "1.080" "1.381" "1.502" "1.189" "579.6" "563.9" "835.4" "643.3" "659.9" "885.2" "626.2" "800.8" "870.4" "689.1" "" "" "" "" "" "" "" "" "" "" "579.6" "477.1" "528.2" "469.0" "540.7" "687.4" "482.7" "688.5" "679.4" "619.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "31.125" "20" "4" "9" "4" "264" "29.6" "6.15" "30.25" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "0.999" "1.082" "1.000" "0.886" "1.072" "0.979" "0.967" "1.094" "1.039" "241.4" "241.2" "261.3" "241.4" "213.8" "258.8" "236.3" "233.4" "264.0" "250.8" "" "" "" "" "" "" "" "" "" "" "241.4" "204.0" "165.2" "176.0" "175.1" "200.9" "182.1" "200.7" "206.1" "225.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "31.120" "22" "10" "13" "10" "391" "42.3" "10.05" "40.33" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA processing" "RND2 GTPase cycle; mRNA Splicing - Major Pathway; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "8" "0" "1.072" "1.430" "1.075" "1.062" "1.527" "1.070" "1.113" "1.516" "1.230" "518.2" "555.2" "740.9" "557.2" "550.3" "791.4" "554.5" "576.5" "785.3" "637.1" "" "" "" "" "" "" "" "" "" "" "518.2" "469.7" "468.5" "406.3" "450.9" "614.6" "427.4" "495.7" "612.9" "572.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "31.076" "10" "8" "10" "4" "740" "83.7" "6.89" "34.60" "8" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "18" "0" "0.935" "0.742" "0.940" "0.884" "0.817" "0.928" "0.896" "0.718" "0.954" "120.1" "112.3" "89.2" "112.9" "106.1" "98.1" "111.5" "107.7" "86.2" "114.6" "" "" "" "" "" "" "" "" "" "" "120.1" "95.0" "56.4" "82.4" "86.9" "76.2" "85.9" "92.6" "67.3" "103.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "31.075" "2" "10" "12" "10" "4861" "531.9" "6.04" "35.64" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.121" "0.882" "1.160" "1.068" "0.996" "1.102" "1.130" "0.975" "1.043" "227.0" "254.4" "200.3" "263.4" "242.5" "226.1" "250.1" "256.4" "221.2" "236.7" "" "" "" "" "" "" "" "" "" "" "227.0" "215.2" "126.6" "192.0" "198.7" "175.6" "192.8" "220.5" "172.7" "212.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.000" "False" "31.072" "9" "9" "11" "9" "1030" "113.2" "6.35" "35.47" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.120" "0.847" "1.129" "1.059" "0.857" "1.092" "1.028" "0.882" "1.054" "760.6" "852.1" "644.3" "859.0" "805.4" "651.5" "830.5" "781.8" "670.9" "801.4" "" "" "" "" "" "" "" "" "" "" "760.6" "720.9" "407.4" "626.3" "659.9" "506.0" "640.2" "672.2" "523.6" "720.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "31.065" "12" "6" "14" "6" "484" "54.9" "7.11" "49.39" "6" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.986" "1.030" "1.010" "1.020" "1.143" "0.980" "1.077" "1.062" "1.041" "685.4" "675.5" "706.3" "692.5" "699.1" "783.6" "671.4" "738.5" "728.0" "713.6" "" "" "" "" "" "" "" "" "" "" "685.4" "571.5" "446.6" "504.9" "572.8" "608.5" "517.5" "634.9" "568.2" "641.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "31.050" "19" "5" "7" "5" "314" "36.0" "4.61" "30.77" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "0.935" "1.053" "0.979" "1.071" "0.954" "1.026" "1.047" "0.925" "1.012" "694.3" "649.4" "730.8" "679.9" "743.6" "662.4" "712.1" "726.7" "642.1" "702.8" "" "" "" "" "" "" "" "" "" "" "694.3" "549.4" "462.1" "495.7" "609.2" "514.4" "548.9" "624.8" "501.2" "631.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "30.991" "12" "5" "9" "3" "447" "51.7" "6.20" "30.32" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "7" "2" "0.978" "0.950" "0.996" "0.969" "0.882" "0.921" "1.005" "0.940" "0.987" "559.9" "547.8" "531.9" "557.5" "542.4" "493.7" "515.9" "562.5" "526.1" "552.7" "" "" "" "" "" "" "" "" "" "" "559.9" "463.5" "336.3" "406.5" "444.4" "383.4" "397.7" "483.7" "410.6" "496.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "30.891" "8" "5" "5" "5" "925" "106.3" "5.43" "22.02" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Gastric cancer network 1; Primary ovarian insufficiency" "Separation of Sister Chromatids; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "37" "0" "1.108" "0.971" "1.296" "1.230" "0.959" "1.359" "1.179" "0.937" "1.186" "302.8" "335.5" "293.9" "392.4" "372.5" "290.3" "411.4" "357.0" "283.6" "359.0" "" "" "" "" "" "" "" "" "" "" "302.8" "283.8" "185.8" "286.1" "305.2" "225.5" "317.1" "306.9" "221.4" "322.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "30.887" "25" "6" "10" "6" "312" "34.3" "8.43" "35.14" "6" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Ciliary landscape" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.986" "0.950" "1.035" "0.996" "0.992" "1.026" "1.009" "0.928" "1.029" "636.7" "627.8" "604.5" "658.8" "634.0" "631.5" "653.0" "642.6" "590.8" "655.4" "" "" "" "" "" "" "" "" "" "" "636.7" "531.2" "382.3" "480.4" "519.4" "490.4" "503.4" "552.5" "461.1" "589.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "30.883" "21" "8" "12" "8" "341" "39.0" "5.88" "27.43" "8" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "0.992" "1.042" "1.004" "1.189" "1.008" "2.286" "0.984" "0.975" "1.083" "642.0" "636.7" "669.2" "644.6" "763.1" "647.0" "1467.4" "631.8" "626.1" "695.1" "" "" "" "" "" "" "" "" "" "" "642.0" "538.6" "423.1" "470.0" "625.2" "502.4" "1131.1" "543.2" "488.7" "624.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.000" "False" "30.882" "20" "3" "6" "3" "176" "20.7" "10.71" "25.42" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.999" "1.497" "0.981" "1.083" "1.491" "1.039" "1.406" "1.608" "1.238" "422.3" "422.0" "632.3" "414.4" "457.5" "629.7" "438.9" "593.7" "678.9" "522.8" "" "" "" "" "" "" "" "" "" "" "422.3" "357.0" "399.8" "302.2" "374.9" "489.0" "338.3" "510.5" "530.0" "470.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "30.875" "26" "8" "10" "8" "329" "35.2" "8.44" "31.15" "8" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "1.058" "1.117" "1.153" "1.118" "1.125" "1.101" "1.063" "1.063" "1.066" "204.7" "216.5" "228.6" "236.0" "228.8" "230.3" "225.3" "217.5" "217.6" "218.3" "" "" "" "" "" "" "" "" "" "" "204.7" "183.2" "144.5" "172.1" "187.4" "178.9" "173.7" "187.0" "169.8" "196.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "30.858" "27" "6" "12" "6" "212" "23.8" "8.27" "39.67" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "Interconversion of nucleotide di- and triphosphates" "3" "0" "1.020" "0.894" "1.065" "1.075" "0.973" "1.019" "1.037" "1.004" "1.058" "399.4" "407.5" "357.1" "425.2" "429.2" "388.6" "406.9" "414.2" "401.2" "422.7" "" "" "" "" "" "" "" "" "" "" "399.4" "344.8" "225.8" "310.1" "351.6" "301.8" "313.6" "356.1" "313.1" "380.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "30.839" "6" "6" "8" "1" "939" "103.9" "6.96" "26.61" "6" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.110" "1.385" "1.200" "1.091" "1.119" "1.377" "1.234" "1.208" "1.257" "70.6" "78.4" "97.8" "84.7" "77.0" "79.0" "97.2" "87.1" "85.3" "88.8" "" "" "" "" "" "" "" "" "" "" "70.6" "66.3" "61.8" "61.8" "63.1" "61.4" "74.9" "74.9" "66.6" "79.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "30.833" "17" "6" "8" "6" "365" "41.0" "5.16" "24.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "Nucleotide-binding oligomerization domain (NOD) pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "0.988" "0.937" "1.004" "1.023" "1.035" "0.990" "1.052" "1.003" "1.036" "657.1" "649.4" "615.7" "659.5" "672.3" "680.4" "650.6" "691.1" "659.0" "681.1" "" "" "" "" "" "" "" "" "" "" "657.1" "549.4" "389.3" "480.9" "550.8" "528.4" "501.5" "594.2" "514.4" "612.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "30.817" "30" "7" "12" "7" "224" "24.9" "4.82" "39.64" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.007" "1.066" "1.061" "1.144" "1.054" "1.180" "1.043" "0.923" "0.989" "712.3" "717.2" "759.1" "755.6" "815.2" "751.2" "840.5" "742.8" "657.8" "704.8" "" "" "" "" "" "" "" "" "" "" "712.3" "606.7" "480.0" "551.0" "667.9" "583.3" "647.9" "638.6" "513.5" "633.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.000" "False" "30.792" "15" "8" "9" "7" "527" "59.3" "6.76" "28.34" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "" "Post-chaperonin tubulin folding pathway" "1" "1" "1.012" "1.000" "0.975" "0.982" "0.954" "0.919" "0.988" "0.975" "1.009" "635.5" "643.1" "635.3" "619.7" "624.4" "606.0" "584.0" "627.7" "619.3" "641.4" "" "" "" "" "" "" "" "" "" "" "635.5" "544.1" "401.7" "451.8" "511.5" "470.6" "450.2" "539.7" "483.4" "576.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "30.732" "27" "5" "14" "4" "192" "21.4" "7.61" "45.22" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "24" "1" "0.993" "0.972" "1.111" "1.074" "0.994" "1.082" "1.064" "1.041" "0.990" "689.8" "685.2" "670.3" "766.0" "741.1" "685.9" "746.6" "733.8" "717.7" "682.6" "" "" "" "" "" "" "" "" "" "" "689.8" "579.7" "423.9" "558.6" "607.2" "532.6" "575.5" "630.9" "560.2" "613.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "30.717" "44" "8" "17" "8" "158" "18.4" "10.30" "47.45" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "21" "0" "0.949" "1.137" "0.993" "1.038" "1.181" "1.050" "1.161" "1.153" "1.056" "1038.7" "986.2" "1180.5" "1031.4" "1078.2" "1227.1" "1090.8" "1205.6" "1197.4" "1096.9" "" "" "" "" "" "" "" "" "" "" "1038.7" "834.3" "746.4" "752.0" "883.4" "952.9" "840.8" "1036.6" "934.6" "986.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "30.710" "12" "5" "8" "5" "503" "57.6" "7.14" "25.44" "5" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "0.960" "0.877" "1.033" "0.974" "0.948" "0.905" "0.976" "0.910" "1.002" "144.4" "138.5" "126.6" "149.1" "140.6" "136.8" "130.6" "140.9" "131.4" "144.6" "" "" "" "" "" "" "" "" "" "" "144.4" "117.2" "80.1" "108.7" "115.2" "106.3" "100.7" "121.1" "102.5" "130.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "30.688" "12" "6" "10" "4" "531" "58.9" "9.64" "35.93" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.997" "0.934" "1.140" "1.042" "0.958" "1.083" "1.114" "0.883" "1.032" "530.5" "529.1" "495.3" "605.0" "552.9" "508.0" "574.5" "591.1" "468.6" "547.5" "" "" "" "" "" "" "" "" "" "" "530.5" "447.7" "313.2" "441.1" "453.0" "394.5" "442.8" "508.2" "365.7" "492.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "30.671" "6" "6" "11" "4" "1147" "125.8" "9.55" "35.70" "6" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "1.002" "1.001" "1.031" "1.028" "0.999" "1.105" "1.029" "0.880" "0.953" "546.2" "547.3" "546.7" "563.0" "561.3" "545.9" "603.4" "562.2" "480.8" "520.6" "" "" "" "" "" "" "" "" "" "" "546.2" "463.0" "345.7" "410.5" "459.9" "423.9" "465.1" "483.4" "375.3" "468.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "30.504" "17" "5" "6" "2" "355" "40.4" "5.54" "23.05" "5" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "22" "0" "1.008" "1.052" "0.976" "0.997" "1.064" "0.972" "0.981" "1.000" "1.087" "185.5" "186.9" "195.2" "181.1" "185.0" "197.3" "180.3" "182.0" "185.5" "201.6" "" "" "" "" "" "" "" "" "" "" "185.5" "158.2" "123.5" "132.0" "151.6" "153.2" "139.0" "156.5" "144.8" "181.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "30.499" "11" "4" "9" "4" "483" "55.8" "6.48" "30.95" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Proximal tubule transport" "ROS and RNS production in phagocytes; Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "9" "0" "1.015" "1.118" "1.011" "0.997" "1.009" "1.018" "1.109" "1.042" "1.084" "287.7" "292.0" "321.7" "290.8" "286.8" "290.3" "292.9" "318.9" "299.8" "311.9" "" "" "" "" "" "" "" "" "" "" "287.7" "247.1" "203.4" "212.0" "235.0" "225.5" "225.7" "274.2" "234.0" "280.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "30.495" "22" "5" "10" "5" "329" "36.5" "4.64" "34.94" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.105" "0.903" "1.007" "1.011" "1.084" "1.115" "1.034" "1.082" "0.865" "176.2" "194.7" "159.2" "177.5" "178.2" "191.0" "196.5" "182.1" "190.7" "152.4" "" "" "" "" "" "" "" "" "" "" "176.2" "164.7" "100.6" "129.4" "146.0" "148.3" "151.5" "156.6" "148.8" "137.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "30.460" "28" "7" "11" "7" "260" "29.9" "5.73" "34.67" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "0.846" "1.194" "0.994" "0.736" "1.199" "1.018" "1.022" "1.240" "1.071" "362.4" "306.7" "432.7" "360.4" "266.8" "434.5" "368.9" "370.2" "449.5" "388.0" "" "" "" "" "" "" "" "" "" "" "362.4" "259.4" "273.6" "262.8" "218.6" "337.4" "284.4" "318.3" "350.8" "348.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "30.398" "9" "6" "8" "6" "683" "77.5" "9.50" "27.10" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.044" "0.964" "1.063" "0.988" "0.983" "1.036" "1.058" "0.926" "0.962" "680.2" "710.1" "655.9" "723.1" "671.9" "668.6" "704.6" "719.7" "630.0" "654.3" "" "" "" "" "" "" "" "" "" "" "680.2" "600.8" "414.8" "527.3" "550.5" "519.2" "543.1" "618.8" "491.8" "588.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "30.375" "18" "5" "8" "4" "411" "43.2" "10.04" "28.39" "5" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "Effect of progerin on genes involved in progeria" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "3" "1" "1.021" "0.920" "1.025" "1.055" "1.044" "1.052" "1.152" "1.027" "1.047" "357.6" "365.0" "328.8" "366.6" "377.2" "373.2" "376.1" "412.1" "367.1" "374.5" "" "" "" "" "" "" "" "" "" "" "357.6" "308.8" "207.9" "267.3" "309.0" "289.8" "289.9" "354.3" "286.6" "336.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "High" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.000" "False" "30.375" "15" "7" "9" "7" "520" "58.8" "8.78" "30.49" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "" "mRNA Splicing - Major Pathway; Basigin interactions" "2" "0" "1.097" "0.855" "0.922" "0.994" "0.922" "1.024" "1.105" "0.904" "1.019" "488.0" "535.1" "417.3" "450.0" "485.0" "449.8" "499.5" "539.0" "440.9" "497.3" "" "" "" "" "" "" "" "" "" "" "488.0" "452.7" "263.9" "328.1" "397.4" "349.3" "385.0" "463.4" "344.2" "447.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "30.370" "18" "6" "10" "6" "359" "40.3" "6.74" "34.58" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialylation" "Sialic acid metabolism" "2" "0" "0.963" "1.102" "0.989" "0.968" "0.931" "0.907" "1.025" "1.070" "1.087" "493.9" "475.7" "544.4" "488.5" "478.3" "460.0" "447.8" "506.4" "528.4" "536.7" "" "" "" "" "" "" "" "" "" "" "493.9" "402.4" "344.3" "356.2" "391.9" "357.2" "345.1" "435.4" "412.5" "482.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "High" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.000" "False" "30.356" "3" "8" "9" "7" "2581" "290.3" "6.47" "28.30" "8" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex" "5" "1" "1.019" "0.837" "1.048" "1.079" "0.893" "1.084" "1.057" "0.865" "0.959" "511.9" "521.8" "428.5" "536.4" "552.5" "457.3" "555.0" "541.2" "442.8" "490.7" "" "" "" "" "" "" "" "" "" "" "511.9" "441.4" "270.9" "391.1" "452.7" "355.1" "427.8" "465.3" "345.6" "441.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "30.336" "29" "7" "12" "7" "241" "26.5" "8.13" "39.54" "7" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "63" "0" "1.038" "1.087" "0.953" "0.999" "0.966" "0.988" "1.004" "1.137" "1.166" "549.1" "570.0" "596.6" "523.2" "548.4" "530.4" "542.2" "551.4" "624.1" "640.1" "" "" "" "" "" "" "" "" "" "" "549.1" "482.2" "377.2" "381.5" "449.3" "411.9" "418.0" "474.1" "487.2" "575.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "30.336" "30" "6" "11" "6" "210" "23.7" "6.42" "44.67" "6" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.966" "1.045" "0.990" "0.935" "1.071" "1.060" "0.917" "1.100" "0.947" "1007.8" "974.0" "1053.6" "997.6" "942.3" "1079.0" "1068.2" "924.5" "1109.0" "954.3" "" "" "" "" "" "" "" "" "" "" "1007.8" "824.0" "666.2" "727.4" "772.0" "837.9" "823.4" "794.9" "865.6" "858.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.000" "False" "30.328" "10" "10" "12" "10" "905" "102.1" "6.23" "37.35" "10" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "Netrin-UNC5B signaling pathway" "" "1" "0" "1.053" "0.790" "1.017" "0.998" "0.787" "0.977" "0.981" "0.790" "0.936" "559.6" "589.2" "442.3" "569.0" "558.5" "440.4" "546.9" "548.8" "441.8" "523.7" "" "" "" "" "" "" "" "" "" "" "559.6" "498.5" "279.6" "414.9" "457.6" "342.0" "421.6" "471.9" "344.9" "470.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "30.313" "19" "4" "19" "4" "201" "23.3" "5.29" "66.99" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA" "2" "0" "0.900" "0.940" "0.984" "1.037" "0.942" "1.182" "0.971" "0.924" "1.009" "2053.9" "1847.9" "1931.6" "2020.9" "2130.3" "1935.2" "2428.5" "1995.0" "1897.0" "2073.0" "" "" "" "" "" "" "" "" "" "" "2053.9" "1563.4" "1221.4" "1473.6" "1745.4" "1502.8" "1872.0" "1715.3" "1480.7" "1863.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "30.260" "6" "4" "9" "4" "606" "63.8" "8.48" "33.01" "4" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "1.034" "0.814" "1.019" "1.183" "0.893" "1.187" "1.086" "0.827" "0.966" "249.5" "257.9" "203.0" "254.1" "295.2" "222.7" "296.2" "271.0" "206.2" "240.9" "" "" "" "" "" "" "" "" "" "" "249.5" "218.2" "128.4" "185.3" "241.9" "172.9" "228.3" "233.0" "161.0" "216.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "30.251" "35" "4" "8" "4" "158" "18.3" "7.88" "25.23" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.828" "0.997" "0.961" "0.980" "1.096" "1.014" "0.891" "0.942" "0.986" "223.2" "184.8" "222.4" "214.6" "218.8" "244.5" "226.4" "198.8" "210.2" "220.1" "" "" "" "" "" "" "" "" "" "" "223.2" "156.3" "140.6" "156.5" "179.2" "189.9" "174.5" "170.9" "164.1" "197.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "30.225" "20" "7" "11" "7" "385" "42.2" "8.46" "38.41" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "2" "0" "1.041" "1.116" "0.974" "0.995" "1.036" "0.996" "0.988" "1.036" "1.008" "688.7" "716.8" "768.5" "670.7" "685.2" "713.2" "686.3" "680.3" "713.5" "694.3" "" "" "" "" "" "" "" "" "" "" "688.7" "606.4" "485.9" "489.1" "561.4" "553.9" "529.0" "584.9" "557.0" "624.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "30.215" "20" "5" "8" "5" "266" "30.0" "10.61" "29.08" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.839" "1.276" "0.975" "1.023" "1.504" "1.028" "1.309" "1.377" "1.119" "157.0" "131.7" "200.3" "153.1" "160.6" "236.0" "161.3" "205.4" "216.1" "175.6" "" "" "" "" "" "" "" "" "" "" "157.0" "111.4" "126.7" "111.6" "131.6" "183.3" "124.4" "176.6" "168.7" "157.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.000" "False" "30.204" "9" "6" "9" "6" "777" "86.0" "6.71" "30.83" "6" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "0" "1.122" "0.780" "0.987" "1.012" "0.896" "0.944" "0.939" "0.811" "0.935" "259.5" "291.2" "202.5" "256.1" "262.8" "232.6" "245.0" "243.7" "210.5" "242.6" "" "" "" "" "" "" "" "" "" "" "259.5" "246.4" "128.1" "186.8" "215.3" "180.7" "188.8" "209.5" "164.3" "218.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "30.190" "8" "5" "7" "5" "729" "78.8" "5.48" "24.98" "5" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "0.899" "0.972" "0.931" "0.990" "0.969" "0.947" "1.014" "1.030" "1.024" "186.8" "167.9" "181.6" "173.8" "185.0" "181.0" "176.9" "189.4" "192.3" "191.3" "" "" "" "" "" "" "" "" "" "" "186.8" "142.0" "114.8" "126.7" "151.5" "140.5" "136.4" "162.8" "150.1" "172.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993927886623036395" "False" "High" "IsMasterProtein" "P31947" "14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1" "0.000" "False" "30.174" "17" "5" "40" "1" "248" "27.8" "4.74" "108.87" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "2810" "ENSG00000175793" "SFN" "hsa:2810; P31947; Q6FH30; Q6FH51; Q96DH0" "miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; p53 transcriptional gene network; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; DNA damage response" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" "16" "0" "1.172" "1.111" "1.177" "1.310" "1.127" "1.059" "1.160" "1.239" "1.093" "69.5" "81.5" "77.3" "81.9" "91.1" "78.4" "73.6" "80.7" "86.2" "76.0" "" "" "" "" "" "" "" "" "" "" "69.5" "69.0" "48.9" "59.7" "74.6" "60.9" "56.8" "69.4" "67.3" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "30.161" "9" "9" "11" "9" "968" "112.1" "6.95" "31.88" "9" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "4" "0" "1.086" "1.020" "1.013" "1.072" "1.006" "1.006" "1.086" "0.999" "0.969" "427.3" "464.2" "435.8" "433.0" "458.0" "429.9" "429.7" "464.0" "426.9" "414.1" "" "" "" "" "" "" "" "" "" "" "427.3" "392.8" "275.6" "315.7" "375.2" "333.8" "331.3" "399.0" "333.2" "372.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "30.116" "15" "6" "8" "6" "364" "39.7" "5.35" "28.35" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "2" "0" "0.965" "1.020" "0.974" "0.990" "1.051" "1.028" "1.054" "1.011" "0.928" "329.3" "317.8" "336.0" "320.8" "325.9" "346.1" "338.6" "347.1" "333.1" "305.6" "" "" "" "" "" "" "" "" "" "" "329.3" "268.8" "212.5" "233.9" "267.0" "268.8" "261.0" "298.5" "260.0" "274.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962903921157164287" "False" "High" "IsMasterProtein" "Q8IYD1" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B OS=Homo sapiens OX=9606 GN=GSPT2 PE=1 SV=2" "0.000" "False" "30.100" "10" "6" "8" "1" "628" "68.8" "5.43" "29.40" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf07145" "23708" "ENSG00000189369" "GSPT2" "hsa:23708; Q8IYD1; Q9H909; Q9NVY0; Q9NY44" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "5" "0" "1.133" "0.899" "1.151" "1.147" "1.198" "1.205" "1.206" "1.091" "1.055" "147.8" "167.4" "132.9" "170.1" "169.5" "177.0" "178.2" "178.3" "161.2" "155.9" "" "" "" "" "" "" "" "" "" "" "147.8" "141.7" "84.0" "124.1" "138.9" "137.5" "137.3" "153.3" "125.8" "140.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "30.100" "11" "7" "11" "7" "592" "67.5" "4.60" "37.46" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "15q11q13 copy number variation" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "9" "0" "1.014" "1.007" "0.958" "1.110" "1.014" "1.115" "1.047" "0.977" "0.995" "629.1" "637.7" "633.5" "602.9" "698.3" "637.7" "701.6" "658.8" "614.4" "626.1" "" "" "" "" "" "" "" "" "" "" "629.1" "539.5" "400.5" "439.6" "572.1" "495.2" "540.8" "566.4" "479.6" "562.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "30.039" "14" "9" "12" "9" "676" "77.5" "7.75" "36.24" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; VEGFR2 mediated cell proliferation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "47" "0" "1.009" "0.915" "1.089" "1.032" "0.896" "1.046" "1.079" "0.826" "1.009" "224.5" "226.5" "205.4" "244.4" "231.6" "201.1" "234.7" "242.1" "185.4" "226.4" "" "" "" "" "" "" "" "" "" "" "224.5" "191.7" "129.9" "178.2" "189.7" "156.2" "180.9" "208.2" "144.7" "203.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "30.019" "29" "5" "9" "5" "188" "21.6" "11.72" "30.51" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.918" "1.394" "1.090" "1.192" "1.373" "1.117" "1.333" "1.400" "1.244" "372.9" "342.2" "519.9" "406.3" "444.5" "512.0" "416.5" "497.0" "522.0" "464.0" "" "" "" "" "" "" "" "" "" "" "372.9" "289.5" "328.7" "296.3" "364.2" "397.6" "321.1" "427.4" "407.5" "417.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "30.013" "17" "7" "11" "7" "392" "42.9" "7.09" "34.54" "7" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "2q37 copy number variation syndrome" "" "1" "0" "1.088" "0.967" "1.046" "1.002" "0.982" "0.994" "0.994" "1.017" "0.986" "621.3" "676.2" "601.0" "649.9" "622.4" "610.1" "617.7" "617.5" "632.1" "612.7" "" "" "" "" "" "" "" "" "" "" "621.3" "572.1" "380.0" "473.9" "509.9" "473.8" "476.1" "530.9" "493.4" "550.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "29.913" "22" "5" "8" "5" "277" "30.2" "8.09" "23.86" "5" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Primary ovarian insufficiency" "Mitochondrial protein degradation" "2" "0" "1.169" "1.219" "1.106" "1.247" "1.176" "1.118" "1.156" "1.132" "1.152" "147.1" "171.9" "179.3" "162.7" "183.4" "172.9" "164.4" "170.0" "166.5" "169.4" "" "" "" "" "" "" "" "" "" "" "147.1" "145.4" "113.4" "118.6" "150.3" "134.3" "126.7" "146.1" "130.0" "152.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "29.883" "22" "4" "10" "4" "216" "25.1" "6.73" "34.90" "4" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Pleural mesothelioma" "Signaling by Hippo" "2" "0" "0.904" "1.028" "0.986" "0.978" "1.025" "0.931" "0.982" "0.975" "0.989" "566.5" "512.1" "582.1" "558.8" "554.2" "580.7" "527.6" "556.1" "552.5" "560.3" "" "" "" "" "" "" "" "" "" "" "566.5" "433.2" "368.1" "407.5" "454.1" "450.9" "406.7" "478.1" "431.2" "503.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "29.878" "19" "6" "7" "6" "468" "54.4" "5.68" "22.67" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.072" "1.039" "1.067" "1.036" "1.133" "1.069" "1.069" "1.089" "1.041" "460.0" "493.1" "477.7" "491.0" "476.4" "521.4" "491.7" "491.5" "500.7" "478.8" "" "" "" "" "" "" "" "" "" "" "460.0" "417.2" "302.1" "358.0" "390.3" "404.9" "379.0" "422.6" "390.8" "430.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "29.877" "12" "7" "8" "7" "742" "82.8" "5.10" "24.90" "7" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "0.996" "0.823" "0.944" "0.843" "0.769" "0.893" "0.947" "0.821" "0.921" "208.1" "207.3" "171.3" "196.5" "175.5" "160.0" "185.9" "197.2" "170.9" "191.7" "" "" "" "" "" "" "" "" "" "" "208.1" "175.4" "108.3" "143.3" "143.8" "124.3" "143.3" "169.5" "133.4" "172.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267228453861492918" "False" "High" "IsMasterProtein" "Q8IVM0" "Coiled-coil domain-containing protein 50 OS=Homo sapiens OX=9606 GN=CCDC50 PE=1 SV=1" "0.000" "False" "29.810" "18" "5" "12" "5" "306" "35.8" "6.65" "45.97" "5" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf15295" "152137" "ENSG00000152492" "CCDC50" "hsa:152137; Q86VH7; Q8IVM0" "" "" "0" "0" "1.000" "1.056" "0.995" "1.084" "1.130" "1.193" "1.042" "1.059" "1.077" "585.9" "586.0" "618.7" "582.9" "634.8" "662.1" "699.1" "610.3" "620.8" "630.9" "" "" "" "" "" "" "" "" "" "" "585.9" "495.7" "391.2" "425.0" "520.1" "514.2" "538.9" "524.7" "484.5" "567.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "29.788" "32" "6" "9" "6" "261" "28.9" "4.78" "26.41" "6" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.090" "1.219" "1.197" "1.062" "1.073" "1.020" "1.172" "1.261" "1.137" "169.7" "184.9" "207.0" "203.2" "180.3" "182.1" "173.2" "198.9" "214.0" "193.0" "" "" "" "" "" "" "" "" "" "" "169.7" "156.5" "130.9" "148.2" "147.7" "141.4" "133.5" "171.0" "167.0" "173.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "29.744" "16" "7" "8" "7" "414" "47.6" "6.18" "28.06" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.194" "1.003" "1.074" "1.075" "0.960" "0.997" "1.001" "0.947" "0.974" "611.3" "729.9" "613.2" "656.5" "657.3" "587.0" "609.4" "612.1" "579.1" "595.3" "" "" "" "" "" "" "" "" "" "" "611.3" "617.5" "387.7" "478.7" "538.5" "455.9" "469.7" "526.3" "452.0" "535.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "29.739" "9" "10" "12" "9" "1044" "119.4" "7.18" "34.60" "10" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "56" "1" "1.031" "0.975" "1.056" "1.099" "0.948" "1.112" "0.994" "0.996" "1.129" "219.5" "226.2" "214.0" "231.8" "241.3" "208.0" "244.2" "218.2" "218.7" "247.8" "" "" "" "" "" "" "" "" "" "" "219.5" "191.4" "135.3" "169.0" "197.7" "161.6" "188.2" "187.6" "170.7" "222.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "29.718" "20" "6" "8" "6" "390" "43.0" "5.26" "28.24" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "B cell receptor signaling pathway" "Neutrophil degranulation; PKR-mediated signaling" "3" "0" "1.097" "1.220" "1.075" "1.000" "1.338" "1.014" "1.063" "1.222" "1.126" "400.5" "439.5" "488.7" "430.6" "400.7" "535.8" "406.1" "425.7" "489.4" "450.9" "" "" "" "" "" "" "" "" "" "" "400.5" "371.8" "309.0" "314.0" "328.3" "416.1" "313.1" "366.0" "382.0" "405.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "29.697" "19" "7" "9" "7" "368" "42.0" "8.63" "24.25" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "1.111" "1.077" "1.200" "1.271" "0.992" "1.111" "1.103" "1.058" "1.177" "275.0" "305.6" "296.2" "330.0" "349.4" "272.8" "305.5" "303.3" "290.9" "323.6" "" "" "" "" "" "" "" "" "" "" "275.0" "258.5" "187.3" "240.6" "286.3" "211.8" "235.5" "260.8" "227.1" "290.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "29.687" "28" "7" "8" "7" "316" "36.0" "5.92" "24.14" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "1.082" "1.009" "1.109" "1.074" "1.174" "1.092" "1.092" "1.046" "0.960" "550.0" "595.0" "554.7" "610.1" "590.9" "645.7" "600.4" "600.6" "575.0" "528.2" "" "" "" "" "" "" "" "" "" "" "550.0" "503.4" "350.7" "444.9" "484.2" "501.5" "462.8" "516.4" "448.9" "474.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "29.684" "39" "4" "17" "4" "103" "11.4" "11.36" "49.72" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Promoter Opening; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; SUMOylation of chromatin organization proteins; Transcriptional regulation by small RNAs; Processing of DNA double-strand break ends; Amyloid fiber formation; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "52" "0" "1.202" "1.080" "1.136" "1.121" "1.131" "1.113" "1.115" "1.071" "1.085" "593.3" "713.2" "640.8" "674.2" "665.0" "670.7" "660.4" "661.7" "635.6" "643.6" "" "" "" "" "" "" "" "" "" "" "593.3" "603.4" "405.2" "491.6" "544.8" "520.8" "509.1" "568.9" "496.2" "578.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "29.678" "22" "6" "11" "5" "326" "36.9" "6.46" "30.94" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Cyclin D associated events in G1; Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "30" "0" "0.962" "0.714" "0.980" "1.051" "0.757" "0.951" "1.032" "0.801" "0.982" "419.2" "403.4" "299.3" "410.8" "440.5" "317.4" "398.4" "432.4" "335.8" "411.6" "" "" "" "" "" "" "" "" "" "" "419.2" "341.2" "189.2" "299.6" "360.9" "246.5" "307.1" "371.7" "262.1" "370.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "29.675" "9" "5" "10" "5" "654" "73.2" "6.33" "33.59" "5" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "" "mRNA Splicing - Major Pathway" "1" "0" "1.059" "0.906" "1.065" "1.064" "0.975" "1.100" "1.090" "0.929" "0.930" "502.5" "532.2" "455.4" "535.3" "534.8" "489.9" "552.9" "547.6" "466.9" "467.3" "" "" "" "" "" "" "" "" "" "" "502.5" "450.2" "287.9" "390.3" "438.1" "380.5" "426.2" "470.8" "364.5" "420.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508396415838456263" "False" "High" "IsMasterProtein" "Q5JXB2" "Putative ubiquitin-conjugating enzyme E2 N-like OS=Homo sapiens OX=9606 GN=UBE2NL PE=1 SV=1" "0.000" "False" "29.671" "29" "5" "19" "1" "153" "17.4" "5.92" "51.88" "5" "protein metabolism;other metabolic processes" "nucleus" "other molecular function" "Pf00179" "389898" "" "UBE2NL" "E9KL27; hsa:389898; Q5JXB2" "" "" "0" "4" "0.932" "1.088" "1.066" "0.995" "1.116" "1.053" "0.933" "1.054" "1.071" "505.0" "470.5" "549.3" "538.4" "502.5" "563.8" "531.8" "471.2" "532.2" "541.1" "" "" "" "" "" "" "" "" "" "" "505.0" "398.1" "347.4" "392.6" "411.7" "437.8" "409.9" "405.2" "415.4" "486.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021992825547666354" "False" "High" "IsMasterProtein" "Q8TDB6" "E3 ubiquitin-protein ligase DTX3L OS=Homo sapiens OX=9606 GN=DTX3L PE=1 SV=1" "0.000" "False" "29.649" "11" "7" "7" "7" "740" "83.5" "8.06" "27.82" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf13923, Pf18102, Pf21717, Pf21718" "151636" "ENSG00000163840" "DTX3L" "B3KWH6; Q53ZZ3; Q5MJP7; Q8TDB6" "Notch signaling" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.082" "1.053" "1.025" "1.062" "1.090" "0.984" "1.023" "0.989" "1.077" "345.6" "373.8" "364.0" "354.1" "366.9" "376.7" "340.1" "353.4" "341.7" "372.2" "" "" "" "" "" "" "" "" "" "" "345.6" "316.2" "230.2" "258.2" "300.6" "292.5" "262.2" "303.9" "266.8" "334.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "29.566" "13" "9" "10" "9" "856" "95.7" "6.92" "31.26" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "1.129" "1.199" "1.042" "1.123" "1.199" "1.040" "1.168" "1.231" "1.126" "486.8" "549.5" "583.6" "507.3" "546.8" "583.5" "506.4" "568.4" "599.1" "548.3" "" "" "" "" "" "" "" "" "" "" "486.8" "464.9" "369.0" "369.9" "448.0" "453.1" "390.3" "488.7" "467.7" "492.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "29.540" "9" "4" "7" "4" "464" "49.2" "9.64" "23.58" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.045" "1.301" "1.039" "1.077" "1.233" "1.095" "1.079" "1.145" "1.063" "462.1" "483.1" "601.1" "480.3" "497.7" "569.5" "505.9" "498.8" "529.3" "491.2" "" "" "" "" "" "" "" "" "" "" "462.1" "408.7" "380.1" "350.2" "407.8" "442.3" "390.0" "428.8" "413.1" "441.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "29.527" "14" "7" "8" "5" "507" "57.0" "6.32" "29.39" "7" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.021" "0.914" "1.081" "1.019" "0.849" "0.985" "1.034" "0.947" "1.042" "296.4" "302.8" "271.0" "320.5" "302.0" "251.6" "292.1" "306.6" "280.7" "308.9" "" "" "" "" "" "" "" "" "" "" "296.4" "256.1" "171.4" "233.7" "247.4" "195.4" "225.2" "263.6" "219.1" "277.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "29.494" "19" "4" "9" "4" "259" "28.5" "6.24" "31.50" "4" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "1.049" "1.018" "1.120" "1.004" "1.053" "1.060" "1.028" "1.053" "1.118" "228.5" "239.6" "232.5" "255.8" "229.3" "240.6" "242.1" "234.9" "240.5" "255.5" "" "" "" "" "" "" "" "" "" "" "228.5" "202.7" "147.0" "186.5" "187.9" "186.9" "186.6" "202.0" "187.7" "229.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "29.482" "18" "4" "6" "4" "310" "33.6" "8.43" "24.69" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "" "tRNA processing in the nucleus" "1" "0" "0.878" "0.742" "1.049" "0.926" "0.843" "1.125" "0.998" "0.849" "0.964" "117.8" "103.4" "87.4" "123.6" "109.0" "99.2" "132.6" "117.5" "100.0" "113.6" "" "" "" "" "" "" "" "" "" "" "117.8" "87.5" "55.3" "90.1" "89.3" "77.1" "102.2" "101.0" "78.0" "102.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "29.461" "10" "8" "9" "8" "824" "93.5" "5.44" "31.57" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "0.995" "0.996" "0.968" "1.047" "0.915" "0.993" "0.999" "0.899" "0.958" "583.8" "580.6" "581.6" "565.1" "611.2" "534.3" "579.5" "583.3" "524.8" "559.5" "" "" "" "" "" "" "" "" "" "" "583.8" "491.2" "367.7" "412.0" "500.8" "414.9" "446.7" "501.5" "409.6" "503.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "29.422" "15" "7" "8" "6" "489" "54.8" "5.16" "23.90" "7" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "3q29 copy number variation syndrome" "Neddylation; KEAP1-NFE2L2 pathway" "3" "1" "0.936" "0.938" "0.943" "1.011" "0.977" "0.990" "1.059" "0.968" "1.005" "455.5" "426.5" "427.2" "429.6" "460.4" "445.2" "451.1" "482.5" "441.1" "457.7" "" "" "" "" "" "" "" "" "" "" "455.5" "360.9" "270.2" "313.2" "377.2" "345.7" "347.7" "414.8" "344.3" "411.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "29.419" "4" "9" "10" "8" "2514" "273.5" "7.59" "31.31" "9" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; SUMOylation of transcription cofactors; HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "23" "0" "0.749" "0.683" "0.897" "0.851" "0.863" "0.810" "0.946" "0.773" "0.821" "158.0" "118.3" "107.9" "141.8" "134.5" "136.3" "128.0" "149.4" "122.1" "129.8" "" "" "" "" "" "" "" "" "" "" "158.0" "100.1" "68.2" "103.4" "110.2" "105.9" "98.7" "128.5" "95.3" "116.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "29.397" "40" "6" "29" "1" "137" "15.5" "8.57" "74.79" "6" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "29.396" "11" "8" "11" "8" "684" "77.4" "5.60" "29.63" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.022" "0.976" "1.093" "1.002" "0.979" "1.057" "1.099" "0.858" "1.039" "403.6" "412.3" "394.0" "441.1" "404.6" "395.1" "426.5" "443.6" "346.4" "419.5" "" "" "" "" "" "" "" "" "" "" "403.6" "348.8" "249.1" "321.6" "331.5" "306.8" "328.8" "381.4" "270.4" "377.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "29.393" "19" "5" "7" "5" "293" "33.8" "6.05" "24.25" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "" "1" "0" "1.008" "0.827" "1.076" "1.125" "0.938" "1.054" "0.951" "0.905" "1.048" "183.0" "184.6" "151.4" "196.9" "206.0" "171.7" "192.9" "174.1" "165.7" "191.8" "" "" "" "" "" "" "" "" "" "" "183.0" "156.1" "95.7" "143.6" "168.8" "133.4" "148.7" "149.7" "129.4" "172.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "29.386" "9" "6" "8" "6" "753" "81.8" "6.20" "26.88" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "0.984" "1.067" "1.038" "1.112" "1.123" "1.099" "1.126" "1.098" "1.017" "519.4" "511.1" "554.2" "539.3" "577.4" "583.2" "571.0" "585.1" "570.2" "528.1" "" "" "" "" "" "" "" "" "" "" "519.4" "432.4" "350.4" "393.2" "473.1" "452.9" "440.1" "503.0" "445.1" "474.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.000" "False" "29.367" "14" "7" "9" "7" "509" "58.8" "7.91" "25.63" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Defective pyroptosis; Polymerase switching on the C-strand of the telomere; Polymerase switching; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation; Removal of the Flap Intermediate" "12" "0" "1.008" "0.983" "1.019" "1.048" "1.037" "1.027" "1.051" "0.914" "1.038" "430.3" "433.9" "423.1" "438.6" "451.0" "446.5" "442.0" "452.1" "393.5" "446.9" "" "" "" "" "" "" "" "" "" "" "430.3" "367.1" "267.5" "319.8" "369.5" "346.7" "340.7" "388.7" "307.2" "401.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "29.364" "8" "6" "7" "6" "812" "89.0" "8.44" "25.43" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "1.100" "0.956" "1.057" "1.006" "0.933" "1.039" "1.021" "0.873" "1.039" "494.0" "543.4" "472.3" "522.0" "497.0" "460.7" "513.4" "504.5" "431.4" "513.4" "" "" "" "" "" "" "" "" "" "" "494.0" "459.7" "298.7" "380.7" "407.2" "357.8" "395.7" "433.8" "336.7" "461.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "29.331" "38" "4" "8" "4" "125" "14.2" "5.26" "30.86" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "" "tRNA modification in the nucleus and cytosol; Methylation; rRNA modification in the nucleus and cytosol; Eukaryotic Translation Termination" "4" "0" "0.995" "0.946" "1.095" "1.080" "0.985" "1.120" "1.035" "0.991" "1.000" "559.9" "556.9" "529.6" "613.0" "604.9" "551.4" "627.2" "579.7" "555.0" "560.0" "" "" "" "" "" "" "" "" "" "" "559.9" "471.2" "334.9" "447.0" "495.6" "428.2" "483.4" "498.4" "433.2" "503.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "29.309" "11" "5" "12" "5" "526" "53.4" "9.36" "40.20" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "5" "0" "0.938" "1.102" "0.934" "0.957" "1.090" "1.102" "0.916" "0.987" "1.045" "1179.8" "1106.7" "1299.9" "1102.3" "1128.7" "1285.9" "1299.6" "1080.2" "1164.1" "1233.4" "" "" "" "" "" "" "" "" "" "" "1179.8" "936.3" "821.9" "803.7" "924.7" "998.6" "1001.8" "928.8" "908.6" "1108.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "29.304" "11" "5" "6" "5" "418" "45.4" "7.99" "23.21" "5" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "0.974" "1.010" "1.034" "0.972" "1.025" "0.949" "0.969" "1.007" "1.069" "761.2" "741.4" "768.6" "787.3" "739.6" "780.3" "722.2" "737.9" "766.5" "813.4" "" "" "" "" "" "" "" "" "" "" "761.2" "627.3" "486.0" "574.0" "606.0" "606.0" "556.7" "634.5" "598.3" "731.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "29.283" "16" "5" "8" "5" "372" "40.9" "8.35" "40.35" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "0.956" "1.024" "0.991" "0.989" "0.968" "0.951" "0.968" "1.032" "0.982" "1087.3" "1039.4" "1113.3" "1077.4" "1075.6" "1052.5" "1034.2" "1052.0" "1121.6" "1068.0" "" "" "" "" "" "" "" "" "" "" "1087.3" "879.3" "703.9" "785.6" "881.2" "817.3" "797.2" "904.5" "875.5" "960.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "29.198" "9" "7" "7" "7" "896" "95.1" "7.12" "25.66" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "1.124" "0.937" "1.183" "1.147" "1.020" "1.067" "1.111" "1.078" "1.152" "429.8" "483.3" "402.7" "508.5" "493.1" "438.6" "458.5" "477.6" "463.5" "495.4" "" "" "" "" "" "" "" "" "" "" "429.8" "408.9" "254.6" "370.7" "404.0" "340.6" "353.4" "410.6" "361.8" "445.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "29.197" "15" "11" "11" "11" "855" "93.5" "6.42" "29.47" "11" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "Ciliopathies" "" "1" "0" "1.019" "0.898" "1.069" "1.163" "0.859" "1.087" "1.030" "0.926" "0.981" "376.7" "384.0" "338.2" "402.7" "438.2" "323.7" "409.5" "388.2" "348.7" "369.6" "" "" "" "" "" "" "" "" "" "" "376.7" "324.9" "213.8" "293.6" "359.0" "251.4" "315.7" "333.7" "272.2" "332.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "29.124" "14" "4" "14" "4" "386" "42.9" "5.30" "43.99" "4" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "4" "0" "1.014" "1.044" "1.067" "1.050" "1.092" "1.067" "1.084" "1.114" "1.209" "327.0" "331.6" "341.3" "348.9" "343.3" "357.1" "348.9" "354.5" "364.3" "395.5" "" "" "" "" "" "" "" "" "" "" "327.0" "280.6" "215.8" "254.4" "281.2" "277.4" "269.0" "304.8" "284.4" "355.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684590373995147366" "False" "High" "IsMasterProtein" "P35237" "Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3" "0.000" "False" "29.086" "12" "4" "7" "4" "376" "42.6" "5.27" "24.96" "4" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5269" "ENSG00000124570" "SERPINB6" "B2RBA8; hsa:5269; P35237; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7" "Ectoderm differentiation" "Neutrophil degranulation; Dissolution of Fibrin Clot" "3" "0" "1.041" "1.131" "1.081" "1.024" "1.029" "0.987" "0.977" "1.043" "0.982" "364.8" "379.7" "412.7" "394.3" "373.5" "375.3" "359.9" "356.5" "380.7" "358.1" "" "" "" "" "" "" "" "" "" "" "364.8" "321.3" "261.0" "287.5" "306.0" "291.5" "277.4" "306.5" "297.1" "321.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "29.026" "40" "4" "18" "4" "127" "14.4" "9.60" "60.92" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "1.084" "1.135" "1.089" "1.175" "1.221" "1.123" "1.038" "1.176" "1.137" "902.0" "977.4" "1024.2" "982.3" "1060.0" "1101.0" "1013.0" "935.9" "1060.5" "1025.7" "" "" "" "" "" "" "" "" "" "" "902.0" "826.9" "647.6" "716.2" "868.5" "855.0" "780.8" "804.7" "827.8" "922.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017615054723730630" "False" "High" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "0.000" "False" "29.008" "7" "7" "17" "3" "864" "101.4" "7.87" "45.10" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "1.213" "1.086" "1.100" "1.114" "1.016" "1.132" "1.215" "1.104" "1.126" "117.5" "142.6" "127.6" "129.3" "130.9" "119.4" "133.1" "142.8" "129.7" "132.4" "" "" "" "" "" "" "" "" "" "" "117.5" "120.7" "80.7" "94.2" "107.2" "92.7" "102.6" "122.8" "101.3" "119.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3870745537767616027" "False" "High" "IsMasterProtein" "Q9UKT9" "Zinc finger protein Aiolos OS=Homo sapiens OX=9606 GN=IKZF3 PE=1 SV=2" "0.000" "False" "28.972" "16" "7" "11" "5" "509" "58.0" "6.55" "32.45" "7" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "22806" "ENSG00000161405" "IKZF3" "B4DVV5; hsa:22806; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3; Q9UKT9" "17q12 copy number variation syndrome" "" "1" "0" "1.087" "0.841" "0.997" "1.275" "0.912" "1.132" "1.197" "0.822" "0.910" "187.0" "203.3" "157.3" "186.6" "238.4" "170.5" "211.8" "223.8" "153.8" "170.1" "" "" "" "" "" "" "" "" "" "" "187.0" "172.0" "99.4" "136.0" "195.3" "132.4" "163.2" "192.4" "120.1" "152.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "High" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.000" "False" "28.968" "13" "9" "11" "9" "642" "71.7" "5.53" "28.92" "9" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "0.970" "0.773" "0.926" "0.911" "0.863" "0.917" "1.130" "0.794" "1.047" "657.4" "637.4" "508.3" "608.7" "599.1" "567.1" "602.9" "742.9" "521.7" "688.6" "" "" "" "" "" "" "" "" "" "" "657.4" "539.3" "321.4" "443.8" "490.8" "440.4" "464.8" "638.8" "407.2" "619.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "28.966" "15" "6" "8" "6" "420" "46.9" "8.54" "24.98" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "" "mRNA Splicing - Major Pathway" "1" "0" "0.948" "1.020" "0.921" "0.859" "0.978" "0.861" "0.898" "0.973" "0.880" "418.1" "396.1" "426.6" "385.2" "359.2" "408.7" "359.8" "375.6" "406.7" "367.8" "" "" "" "" "" "" "" "" "" "" "418.1" "335.1" "269.7" "280.9" "294.3" "317.4" "277.3" "322.9" "317.4" "330.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "28.963" "22" "6" "7" "6" "289" "33.7" "6.74" "25.66" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "" "mRNA Splicing - Major Pathway" "1" "0" "1.011" "1.115" "1.115" "0.979" "1.124" "1.074" "1.069" "1.086" "0.992" "310.6" "314.0" "346.5" "346.5" "304.1" "349.0" "333.7" "332.0" "337.3" "308.2" "" "" "" "" "" "" "" "" "" "" "310.6" "265.7" "219.1" "252.7" "249.2" "271.0" "257.2" "285.5" "263.3" "277.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "28.951" "14" "7" "9" "7" "504" "56.2" "5.48" "28.49" "7" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; ER-Phagosome pathway; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.955" "0.985" "0.946" "0.944" "0.970" "0.895" "0.922" "0.945" "0.877" "308.3" "294.5" "303.5" "291.5" "290.9" "298.9" "275.9" "284.1" "291.4" "270.4" "" "" "" "" "" "" "" "" "" "" "308.3" "249.2" "191.9" "212.6" "238.3" "232.2" "212.7" "244.3" "227.4" "243.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "28.889" "22" "5" "9" "4" "286" "32.9" "5.69" "27.92" "5" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "8" "1" "1.045" "1.107" "1.035" "1.020" "1.074" "1.006" "1.005" "1.135" "1.090" "381.0" "398.1" "421.8" "394.4" "388.4" "409.2" "383.3" "383.0" "432.3" "415.2" "" "" "" "" "" "" "" "" "" "" "381.0" "336.8" "266.7" "287.6" "318.3" "317.7" "295.5" "329.3" "337.4" "373.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "28.832" "19" "6" "11" "6" "288" "32.8" "7.17" "24.62" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.004" "0.985" "1.129" "0.918" "0.915" "0.963" "0.989" "1.035" "0.970" "162.6" "163.1" "160.1" "183.5" "149.3" "148.7" "156.6" "160.8" "168.2" "157.7" "" "" "" "" "" "" "" "" "" "" "162.6" "138.0" "101.3" "133.8" "122.3" "115.5" "120.7" "138.2" "131.3" "141.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "28.802" "17" "8" "10" "8" "552" "63.2" "5.94" "27.89" "8" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.974" "0.972" "0.997" "0.978" "1.007" "0.949" "0.987" "0.989" "1.011" "349.4" "340.4" "339.5" "348.4" "341.8" "351.7" "331.7" "344.8" "345.5" "353.3" "" "" "" "" "" "" "" "" "" "" "349.4" "288.0" "214.7" "254.0" "280.0" "273.1" "255.7" "296.5" "269.6" "317.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.000" "False" "28.749" "15" "8" "9" "8" "582" "65.6" "5.15" "26.90" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "1.030" "0.960" "0.980" "1.105" "1.030" "1.146" "1.249" "1.089" "1.144" "345.2" "355.5" "331.2" "338.2" "381.5" "355.6" "395.4" "431.1" "375.9" "394.9" "" "" "" "" "" "" "" "" "" "" "345.2" "300.7" "209.4" "246.6" "312.6" "276.2" "304.8" "370.6" "293.4" "355.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "28.740" "4" "6" "6" "6" "2098" "237.0" "6.70" "20.33" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "0.988" "0.984" "1.088" "1.097" "0.960" "1.037" "1.037" "0.851" "1.024" "154.5" "152.7" "152.0" "168.1" "169.5" "148.4" "160.3" "160.3" "131.4" "158.2" "" "" "" "" "" "" "" "" "" "" "154.5" "129.2" "96.1" "122.6" "138.9" "115.2" "123.5" "137.8" "102.6" "142.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.000" "False" "28.730" "5" "6" "8" "6" "1941" "211.6" "5.58" "25.99" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "" "CDC42 GTPase cycle" "1" "0" "0.927" "0.806" "1.040" "0.984" "0.946" "0.995" "1.071" "0.806" "0.892" "126.4" "117.1" "101.9" "131.5" "124.3" "119.5" "125.8" "135.4" "101.9" "112.8" "" "" "" "" "" "" "" "" "" "" "126.4" "99.1" "64.4" "95.9" "101.9" "92.8" "96.9" "116.4" "79.5" "101.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "28.714" "35" "3" "6" "3" "102" "11.8" "8.68" "20.25" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "" "Neddylation" "1" "0" "1.163" "1.114" "1.040" "1.121" "1.179" "1.031" "1.011" "1.124" "1.144" "261.2" "303.8" "291.0" "271.6" "292.8" "307.9" "269.2" "264.0" "293.6" "298.8" "" "" "" "" "" "" "" "" "" "" "261.2" "257.0" "184.0" "198.0" "239.9" "239.1" "207.5" "227.0" "229.1" "268.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "28.689" "10" "2" "18" "2" "268" "30.7" "3.85" "62.90" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "1.024" "0.849" "0.953" "1.004" "0.823" "0.943" "1.046" "0.875" "1.075" "562.6" "576.3" "477.4" "536.2" "565.0" "462.9" "530.6" "588.4" "492.5" "604.7" "" "" "" "" "" "" "" "" "" "" "562.6" "487.6" "301.9" "391.0" "462.9" "359.5" "409.0" "505.9" "384.4" "543.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "28.664" "11" "8" "8" "8" "744" "82.5" "6.95" "27.03" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "9" "0" "0.926" "1.099" "0.986" "1.009" "1.183" "1.105" "1.065" "1.126" "1.094" "171.1" "158.4" "188.1" "168.7" "172.6" "202.5" "189.1" "182.3" "192.7" "187.3" "" "" "" "" "" "" "" "" "" "" "171.1" "134.0" "119.0" "123.0" "141.4" "157.3" "145.7" "156.7" "150.4" "168.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "28.661" "28" "8" "11" "8" "299" "33.4" "5.25" "31.81" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.093" "1.027" "1.084" "1.086" "1.086" "1.092" "1.063" "1.072" "1.080" "557.0" "609.0" "572.0" "604.0" "604.8" "605.1" "608.2" "592.0" "597.2" "601.7" "" "" "" "" "" "" "" "" "" "" "557.0" "515.2" "361.7" "440.4" "495.5" "469.9" "468.8" "509.0" "466.2" "540.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "28.653" "15" "8" "10" "8" "516" "56.9" "7.36" "29.96" "8" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "Ciliary landscape" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; RHOG GTPase cycle" "5" "0" "0.954" "0.928" "0.968" "1.014" "0.917" "0.932" "1.031" "0.841" "0.924" "135.7" "129.5" "125.9" "131.4" "137.6" "124.4" "126.5" "139.8" "114.0" "125.4" "" "" "" "" "" "" "" "" "" "" "135.7" "109.6" "79.6" "95.8" "112.8" "96.6" "97.5" "120.2" "89.0" "112.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "28.632" "11" "8" "8" "8" "703" "77.6" "6.95" "27.84" "8" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "0.945" "0.923" "1.022" "1.033" "0.924" "0.988" "1.007" "0.906" "0.937" "809.2" "764.4" "746.9" "826.9" "835.7" "747.8" "799.2" "814.8" "732.8" "758.4" "" "" "" "" "" "" "" "" "" "" "809.2" "646.7" "472.2" "603.0" "684.7" "580.7" "616.0" "700.5" "572.0" "681.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "28.586" "25" "6" "8" "6" "298" "32.8" "9.57" "25.36" "6" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "5" "0" "1.058" "1.041" "1.149" "1.100" "1.056" "1.126" "1.074" "1.058" "1.047" "348.6" "368.7" "362.8" "400.5" "383.5" "368.1" "392.5" "374.4" "368.9" "364.9" "" "" "" "" "" "" "" "" "" "" "348.6" "311.9" "229.4" "292.0" "314.2" "285.8" "302.5" "321.9" "287.9" "328.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "28.577" "28" "5" "11" "3" "162" "18.8" "8.66" "37.58" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "2" "0" "1.025" "0.775" "1.101" "1.062" "0.787" "1.072" "1.085" "0.873" "1.107" "436.0" "447.0" "338.1" "480.1" "463.2" "343.0" "467.4" "473.1" "380.6" "482.9" "" "" "" "" "" "" "" "" "" "" "436.0" "378.2" "213.8" "350.1" "379.5" "266.4" "360.3" "406.8" "297.1" "434.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "28.515" "15" "6" "14" "6" "496" "56.8" "7.80" "41.53" "6" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "3" "0" "0.980" "1.194" "0.971" "1.052" "1.186" "0.975" "1.014" "1.160" "1.152" "580.3" "568.8" "692.9" "563.5" "610.6" "688.3" "565.6" "588.6" "673.1" "668.5" "" "" "" "" "" "" "" "" "" "" "580.3" "481.2" "438.1" "410.9" "500.3" "534.6" "436.0" "506.1" "525.4" "601.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "28.461" "8" "6" "7" "6" "780" "79.2" "5.02" "26.18" "6" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "0.915" "1.009" "0.988" "1.017" "1.079" "1.075" "1.071" "1.081" "1.065" "292.1" "267.3" "294.7" "288.5" "297.0" "315.3" "314.1" "313.0" "315.9" "311.0" "" "" "" "" "" "" "" "" "" "" "292.1" "226.1" "186.3" "210.3" "243.3" "244.8" "242.1" "269.1" "246.6" "279.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "28.447" "12" "9" "9" "9" "660" "71.9" "7.97" "27.24" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "0.943" "0.932" "0.946" "0.977" "0.845" "0.991" "0.975" "0.926" "1.006" "473.4" "446.5" "441.4" "447.7" "462.3" "399.9" "469.1" "461.4" "438.4" "476.4" "" "" "" "" "" "" "" "" "" "" "473.4" "377.8" "279.1" "326.4" "378.8" "310.6" "361.6" "396.7" "342.2" "428.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "28.445" "11" "7" "8" "7" "639" "73.4" "6.20" "24.05" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Lung fibrosis" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "4" "0" "0.995" "0.811" "0.960" "0.918" "0.904" "1.018" "1.057" "0.872" "0.871" "250.5" "249.2" "203.2" "240.5" "229.9" "226.4" "255.1" "264.7" "218.3" "218.2" "" "" "" "" "" "" "" "" "" "" "250.5" "210.8" "128.5" "175.4" "188.4" "175.8" "196.6" "227.6" "170.4" "196.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "28.441" "20" "7" "8" "7" "403" "47.3" "9.36" "26.94" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "0.992" "0.908" "0.960" "0.990" "0.897" "0.984" "0.897" "0.821" "0.852" "329.5" "326.9" "299.1" "316.3" "326.1" "295.5" "324.1" "295.6" "270.5" "280.6" "" "" "" "" "" "" "" "" "" "" "329.5" "276.5" "189.1" "230.6" "267.2" "229.5" "249.8" "254.2" "211.1" "252.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "28.424" "23" "6" "8" "6" "295" "33.2" "5.36" "24.38" "6" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "1.101" "1.302" "1.122" "1.200" "1.464" "1.137" "1.234" "1.319" "1.198" "241.1" "265.4" "313.9" "270.6" "289.4" "353.0" "274.1" "297.6" "318.2" "289.0" "" "" "" "" "" "" "" "" "" "" "241.1" "224.5" "198.5" "197.3" "237.1" "274.1" "211.3" "255.9" "248.3" "259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "28.390" "35" "4" "9" "4" "157" "17.7" "5.07" "32.77" "4" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "1.054" "0.878" "1.019" "1.045" "0.862" "1.063" "1.043" "0.901" "1.052" "505.7" "533.2" "444.1" "515.2" "528.6" "435.8" "537.4" "527.5" "455.6" "532.0" "" "" "" "" "" "" "" "" "" "" "505.7" "451.1" "280.8" "375.7" "433.1" "338.4" "414.2" "453.5" "355.6" "478.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "28.368" "14" "6" "8" "6" "481" "55.7" "6.37" "26.16" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "83" "0" "1.054" "0.826" "1.080" "1.043" "0.953" "1.050" "1.069" "1.005" "0.946" "337.9" "356.3" "279.1" "364.9" "352.4" "322.0" "354.9" "361.2" "339.8" "319.8" "" "" "" "" "" "" "" "" "" "" "337.9" "301.5" "176.4" "266.1" "288.7" "250.1" "273.6" "310.5" "265.2" "287.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "28.326" "14" "6" "8" "6" "607" "68.6" "5.80" "23.98" "6" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "1.085" "0.964" "1.131" "1.052" "0.851" "0.978" "0.899" "0.973" "1.023" "202.3" "219.5" "194.9" "228.9" "212.9" "172.1" "197.9" "181.9" "196.8" "206.9" "" "" "" "" "" "" "" "" "" "" "202.3" "185.7" "123.3" "166.9" "174.4" "133.7" "152.6" "156.4" "153.6" "186.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "28.319" "7" "5" "10" "5" "804" "91.8" "7.42" "29.54" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.115" "0.821" "1.314" "1.070" "0.854" "1.166" "1.090" "0.864" "1.071" "546.0" "608.6" "448.4" "717.4" "584.2" "466.4" "636.7" "595.0" "472.0" "584.6" "" "" "" "" "" "" "" "" "" "" "546.0" "514.9" "283.5" "523.1" "478.7" "362.2" "490.8" "511.6" "368.4" "525.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "High" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.000" "False" "28.279" "15" "7" "12" "7" "491" "53.8" "8.44" "39.26" "7" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "1.124" "1.192" "1.177" "1.116" "1.021" "1.121" "1.104" "1.182" "1.099" "522.8" "587.4" "623.0" "615.1" "583.6" "533.5" "586.0" "577.3" "617.9" "574.4" "" "" "" "" "" "" "" "" "" "" "522.8" "497.0" "394.0" "448.5" "478.2" "414.3" "451.7" "496.4" "482.3" "516.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "High" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.000" "False" "28.278" "33" "7" "10" "7" "230" "25.4" "11.08" "35.61" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.049" "0.878" "1.053" "1.022" "0.872" "1.037" "1.166" "0.865" "0.913" "288.9" "302.9" "253.7" "304.1" "295.3" "252.0" "299.6" "336.7" "249.9" "263.8" "" "" "" "" "" "" "" "" "" "" "288.9" "256.3" "160.4" "221.7" "241.9" "195.7" "231.0" "289.5" "195.0" "237.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "28.269" "9" "9" "12" "9" "777" "86.1" "6.16" "34.71" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "16" "0" "0.893" "1.025" "0.953" "0.947" "1.049" "0.965" "0.988" "1.054" "1.048" "711.6" "635.5" "729.4" "678.2" "674.1" "746.7" "687.0" "703.2" "750.4" "746.1" "" "" "" "" "" "" "" "" "" "" "711.6" "537.7" "461.2" "494.5" "552.3" "579.9" "529.6" "604.6" "585.7" "670.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "28.247" "20" "5" "10" "5" "255" "28.4" "8.62" "33.72" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA processing" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "3" "0" "0.965" "1.027" "1.094" "1.002" "1.083" "1.049" "1.065" "1.029" "1.044" "486.4" "469.2" "499.6" "532.1" "487.4" "526.7" "510.3" "518.0" "500.5" "508.0" "" "" "" "" "" "" "" "" "" "" "486.4" "396.9" "315.9" "387.9" "399.3" "409.0" "393.4" "445.4" "390.7" "456.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6944601348442643793" "False" "High" "IsMasterProtein" "Q460N5" "Protein mono-ADP-ribosyltransferase PARP14 OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3" "0.000" "False" "28.208" "5" "9" "11" "9" "1801" "202.7" "7.18" "28.03" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf01661, Pf02825" "54625" "ENSG00000173193" "PARP14" "B4E2H0; hsa:54625; Q460N4; Q460N5; Q8J027; Q9H9X9; Q9NV60; Q9ULF2" "" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "3" "0" "1.169" "0.940" "1.249" "1.194" "0.908" "1.044" "0.993" "0.989" "1.010" "147.1" "171.9" "138.2" "183.6" "175.6" "133.6" "153.5" "146.0" "145.4" "148.5" "" "" "" "" "" "" "" "" "" "" "147.1" "145.5" "87.4" "133.9" "143.9" "103.7" "118.4" "125.5" "113.5" "133.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.000" "False" "28.185" "6" "6" "7" "6" "1089" "122.0" "5.97" "29.69" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "0.962" "0.749" "1.028" "0.983" "0.793" "1.075" "1.052" "0.794" "0.927" "709.8" "682.9" "532.0" "730.0" "697.7" "562.6" "763.0" "746.5" "563.3" "657.9" "" "" "" "" "" "" "" "" "" "" "709.8" "577.7" "336.4" "532.3" "571.6" "436.9" "588.1" "641.8" "439.7" "591.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "28.177" "7" "10" "11" "10" "1231" "141.2" "5.43" "31.07" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "9" "0" "1.070" "0.825" "1.096" "1.043" "0.826" "0.990" "1.065" "1.050" "1.126" "170.6" "182.5" "140.7" "187.0" "178.0" "141.0" "169.0" "181.7" "179.1" "192.1" "" "" "" "" "" "" "" "" "" "" "170.6" "154.4" "89.0" "136.3" "145.8" "109.5" "130.2" "156.2" "139.8" "172.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765435694013910926" "False" "High" "IsMasterProtein" "Q96Q15" "Serine/threonine-protein kinase SMG1 OS=Homo sapiens OX=9606 GN=SMG1 PE=1 SV=3" "0.000" "False" "28.162" "2" "8" "9" "8" "3661" "410.2" "6.46" "27.29" "8" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02260, Pf15785, Pf17229" "23049" "ENSG00000157106" "SMG1" "hsa:23049; O43305; Q13284; Q8NFX2; Q96Q15; Q96QV0; Q96RW3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.057" "0.901" "0.994" "1.113" "1.034" "1.044" "0.962" "0.982" "0.984" "201.7" "213.2" "181.7" "200.5" "224.4" "208.4" "210.5" "194.1" "198.1" "198.4" "" "" "" "" "" "" "" "" "" "" "201.7" "180.4" "114.9" "146.2" "183.9" "161.9" "162.2" "166.9" "154.6" "178.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5028999113090776511" "False" "High" "IsMasterProtein" "Q8WVB6" "Chromosome transmission fidelity protein 18 homolog OS=Homo sapiens OX=9606 GN=CHTF18 PE=1 SV=1" "0.000" "False" "28.134" "10" "6" "6" "5" "975" "107.3" "7.21" "21.35" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004" "63922" "ENSG00000127586" "CHTF18" "B7ZBA2; D3DU68; hsa:63922; Q7Z6Y4; Q7Z6Y6; Q8WVB6; Q9BR83; Q9BRG5; Q9H7K3" "Gastric cancer network 2; 7q11.23 copy number variation syndrome" "Polymerase switching on the C-strand of the telomere" "3" "0" "0.961" "0.922" "1.137" "1.128" "0.934" "1.040" "1.000" "0.800" "1.000" "105.2" "101.0" "97.0" "119.6" "118.6" "98.2" "109.4" "105.2" "84.1" "105.2" "" "" "" "" "" "" "" "" "" "" "105.2" "85.5" "61.3" "87.2" "97.2" "76.3" "84.3" "90.4" "65.7" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.000" "False" "28.107" "11" "6" "10" "6" "593" "66.4" "6.55" "30.02" "6" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "Platelet degranulation ; Other interleukin signaling" "4" "0" "1.001" "1.103" "1.032" "1.063" "1.099" "1.088" "1.067" "1.019" "0.998" "472.0" "472.5" "520.5" "487.2" "501.7" "518.7" "513.6" "503.7" "481.1" "470.9" "" "" "" "" "" "" "" "" "" "" "472.0" "399.8" "329.1" "355.3" "411.1" "402.8" "395.9" "433.1" "375.5" "423.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "28.064" "11" "6" "7" "6" "656" "75.0" "5.55" "23.75" "6" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "" "Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; HCMV Early Events; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "35" "0" "1.036" "0.783" "1.119" "1.083" "0.787" "1.115" "1.055" "0.790" "0.945" "440.1" "455.8" "344.6" "492.4" "476.7" "346.2" "490.8" "464.5" "347.9" "415.6" "" "" "" "" "" "" "" "" "" "" "440.1" "385.6" "217.9" "359.0" "390.6" "268.8" "378.3" "399.3" "271.5" "373.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "27.973" "14" "5" "6" "5" "403" "44.5" "7.03" "23.99" "5" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.027" "0.972" "0.954" "0.997" "0.848" "1.006" "1.032" "0.920" "1.036" "267.1" "274.2" "259.5" "254.8" "266.3" "226.6" "268.8" "275.7" "245.7" "276.6" "" "" "" "" "" "" "" "" "" "" "267.1" "232.0" "164.1" "185.8" "218.2" "176.0" "207.2" "237.0" "191.8" "248.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "27.971" "22" "4" "11" "4" "245" "26.6" "4.68" "34.77" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "" "2" "0" "1.108" "1.166" "1.143" "1.099" "1.220" "1.100" "1.036" "1.264" "1.243" "267.5" "296.3" "312.0" "305.6" "294.0" "326.3" "294.1" "277.1" "338.0" "332.4" "" "" "" "" "" "" "" "" "" "" "267.5" "250.7" "197.3" "222.8" "240.9" "253.4" "226.7" "238.2" "263.8" "298.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "27.956" "30" "5" "7" "3" "216" "23.5" "8.41" "23.71" "5" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "10" "2" "1.005" "0.952" "1.001" "0.929" "0.973" "1.099" "0.988" "0.986" "1.050" "186.2" "187.2" "177.3" "186.4" "173.0" "181.1" "204.5" "183.9" "183.5" "195.6" "" "" "" "" "" "" "" "" "" "" "186.2" "158.3" "112.1" "135.9" "141.7" "140.6" "157.6" "158.1" "143.2" "175.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "27.946" "9" "6" "32" "1" "641" "70.0" "5.66" "97.37" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "Neutrophil degranulation; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "27.945" "12" "3" "10" "3" "392" "42.9" "5.97" "31.89" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "1.068" "1.095" "1.038" "1.015" "1.172" "1.070" "1.081" "1.132" "1.156" "294.4" "314.4" "322.4" "305.6" "298.8" "344.9" "314.9" "318.2" "333.3" "340.4" "" "" "" "" "" "" "" "" "" "" "294.4" "266.0" "203.9" "222.8" "244.8" "267.8" "242.7" "273.6" "260.2" "306.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.000" "False" "27.936" "15" "8" "10" "8" "551" "62.1" "8.40" "31.98" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "PKR-mediated signaling; ISG15 antiviral mechanism; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "16" "0" "1.040" "0.895" "1.095" "1.098" "0.854" "1.035" "1.109" "0.845" "1.056" "279.4" "290.7" "250.2" "306.0" "306.9" "238.6" "289.1" "310.0" "236.1" "295.1" "" "" "" "" "" "" "" "" "" "" "279.4" "245.9" "158.2" "223.1" "251.4" "185.3" "222.9" "266.5" "184.3" "265.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "27.925" "18" "6" "7" "6" "363" "39.7" "8.02" "24.62" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.935" "0.830" "0.890" "1.048" "0.826" "0.850" "1.005" "0.943" "0.880" "116.7" "109.2" "96.8" "103.8" "122.3" "96.4" "99.2" "117.2" "110.1" "102.7" "" "" "" "" "" "" "" "" "" "" "116.7" "92.4" "61.2" "75.7" "100.2" "74.8" "76.4" "100.8" "85.9" "92.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "27.911" "27" "7" "17" "7" "234" "26.1" "7.78" "42.32" "7" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "0.988" "1.069" "0.945" "0.987" "1.117" "1.048" "0.996" "0.975" "0.923" "853.0" "842.6" "911.9" "806.0" "842.2" "953.1" "893.5" "849.4" "831.5" "787.4" "" "" "" "" "" "" "" "" "" "" "853.0" "712.9" "576.6" "587.7" "690.1" "740.2" "688.8" "730.3" "649.1" "707.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "27.900" "15" "5" "13" "5" "407" "42.1" "5.07" "48.37" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; UCH proteinases" "4" "0" "1.030" "0.979" "0.946" "0.924" "0.900" "0.899" "0.964" "0.931" "1.000" "668.1" "688.0" "654.0" "631.9" "617.3" "601.6" "600.8" "643.8" "622.3" "668.1" "" "" "" "" "" "" "" "" "" "" "668.1" "582.1" "413.5" "460.7" "505.7" "467.2" "463.2" "553.5" "485.7" "600.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "27.864" "8" "5" "10" "2" "579" "62.3" "8.79" "36.84" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "1" "0.914" "1.190" "0.945" "0.936" "1.270" "1.014" "0.956" "1.102" "0.950" "279.4" "255.5" "332.5" "264.2" "261.7" "354.8" "283.3" "267.1" "308.0" "265.6" "" "" "" "" "" "" "" "" "" "" "279.4" "216.2" "210.3" "192.7" "214.4" "275.5" "218.4" "229.6" "240.4" "238.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "27.810" "9" "5" "7" "5" "650" "72.2" "6.24" "25.41" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "1.109" "0.985" "1.130" "1.163" "1.036" "1.068" "1.101" "0.955" "1.234" "432.0" "479.3" "425.5" "488.0" "502.2" "447.6" "461.2" "475.8" "412.6" "533.1" "" "" "" "" "" "" "" "" "" "" "432.0" "405.5" "269.0" "355.8" "411.5" "347.6" "355.5" "409.0" "322.1" "479.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "27.775" "9" "7" "9" "7" "754" "84.9" "6.90" "29.17" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "0.996" "0.830" "1.002" "1.055" "0.882" "1.001" "1.022" "0.863" "0.902" "471.4" "469.4" "391.2" "472.3" "497.2" "415.9" "471.7" "481.6" "406.7" "425.2" "" "" "" "" "" "" "" "" "" "" "471.4" "397.1" "247.4" "344.4" "407.3" "322.9" "363.6" "414.1" "317.4" "382.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "27.754" "40" "4" "11" "4" "121" "13.6" "4.82" "40.05" "4" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "0.986" "1.050" "0.970" "0.991" "1.233" "1.182" "1.002" "1.108" "1.065" "504.0" "496.9" "529.1" "489.0" "499.4" "621.2" "595.9" "504.8" "558.5" "536.7" "" "" "" "" "" "" "" "" "" "" "504.0" "420.4" "334.5" "356.5" "409.1" "482.4" "459.3" "434.0" "436.0" "482.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "27.732" "8" "8" "12" "8" "885" "99.2" "6.10" "37.90" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "1" "0" "0.974" "0.915" "0.982" "0.988" "1.030" "1.015" "0.956" "0.940" "0.999" "550.2" "536.0" "503.5" "540.4" "543.6" "566.5" "558.7" "526.1" "517.0" "549.5" "" "" "" "" "" "" "" "" "" "" "550.2" "453.4" "318.4" "394.0" "445.4" "439.9" "430.7" "452.3" "403.5" "494.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "27.726" "22" "5" "7" "5" "320" "35.3" "8.22" "26.61" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "5" "0" "1.017" "0.889" "1.062" "0.987" "0.955" "0.984" "1.003" "0.990" "1.008" "510.6" "519.2" "453.7" "542.2" "503.9" "487.7" "502.6" "512.0" "505.4" "514.8" "" "" "" "" "" "" "" "" "" "" "510.6" "439.3" "286.9" "395.4" "412.8" "378.7" "387.4" "440.2" "394.5" "462.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "27.715" "10" "7" "9" "7" "729" "83.6" "6.79" "29.80" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "IRF3-mediated induction of type I IFN; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TNFR1-induced proapoptotic signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Interleukin-37 signaling; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "35" "0" "1.036" "0.867" "1.008" "1.026" "0.889" "1.058" "1.023" "0.872" "1.023" "583.8" "604.6" "506.0" "588.3" "599.1" "519.0" "617.7" "597.4" "509.2" "597.1" "" "" "" "" "" "" "" "" "" "" "583.8" "511.5" "319.9" "428.9" "490.9" "403.1" "476.2" "513.6" "397.5" "536.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "27.682" "15" "5" "11" "5" "297" "34.3" "9.72" "30.71" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.019" "1.882" "1.090" "1.232" "1.889" "1.137" "1.637" "1.752" "1.197" "417.0" "425.0" "784.8" "454.4" "513.9" "787.8" "474.3" "682.6" "730.7" "499.3" "" "" "" "" "" "" "" "" "" "" "417.0" "359.6" "496.2" "331.3" "421.0" "611.8" "365.6" "586.9" "570.3" "448.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2963377560695435167" "False" "High" "IsMasterProtein" "Q96P47" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2" "0.000" "False" "27.682" "7" "5" "6" "5" "875" "95.0" "7.97" "23.56" "5" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071, Pf01412, Pf12796" "116988" "ENSG00000133612" "AGAP3" "B3KNZ8; E9PAL8; hsa:116988; Q59EN0; Q96P47; Q96RK3" "" "" "0" "0" "1.026" "0.815" "1.019" "0.966" "0.974" "1.026" "0.989" "0.921" "0.963" "302.1" "310.1" "246.2" "307.9" "291.9" "294.3" "309.9" "298.9" "278.3" "290.8" "" "" "" "" "" "" "" "" "" "" "302.1" "262.3" "155.7" "224.5" "239.1" "228.6" "238.9" "257.0" "217.3" "261.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "27.579" "17" "7" "8" "7" "421" "47.5" "9.07" "28.71" "7" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "" "5" "0" "0.988" "0.922" "0.983" "0.974" "0.969" "0.989" "1.068" "0.944" "0.913" "645.1" "637.6" "594.9" "634.4" "628.3" "625.4" "638.3" "689.0" "609.1" "588.8" "" "" "" "" "" "" "" "" "" "" "645.1" "539.4" "376.2" "462.6" "514.7" "485.7" "492.0" "592.4" "475.4" "529.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "27.532" "36" "7" "19" "7" "198" "21.7" "5.59" "51.48" "7" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "5" "0" "0.901" "0.994" "1.046" "0.973" "1.075" "0.995" "0.965" "1.055" "1.029" "656.1" "591.4" "651.9" "685.9" "638.6" "705.5" "652.9" "632.8" "691.9" "675.0" "" "" "" "" "" "" "" "" "" "" "656.1" "500.3" "412.2" "500.1" "523.2" "547.9" "503.3" "544.1" "540.1" "606.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "27.520" "11" "5" "6" "5" "580" "64.4" "6.42" "20.48" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.999" "1.061" "0.965" "1.098" "1.179" "0.965" "1.058" "1.014" "1.068" "213.5" "213.4" "226.6" "206.1" "234.4" "251.8" "206.0" "226.0" "216.6" "228.0" "" "" "" "" "" "" "" "" "" "" "213.5" "180.5" "143.3" "150.3" "192.1" "195.6" "158.8" "194.3" "169.0" "205.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "27.505" "38" "6" "13" "6" "165" "18.9" "10.15" "41.97" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.048" "1.183" "1.160" "1.027" "1.242" "1.042" "1.202" "1.323" "1.193" "286.8" "300.7" "339.3" "332.8" "294.5" "356.2" "298.8" "344.7" "379.3" "342.1" "" "" "" "" "" "" "" "" "" "" "286.8" "254.4" "214.5" "242.6" "241.3" "276.6" "230.3" "296.4" "296.1" "307.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338471368414013319" "False" "High" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "0.000" "False" "27.503" "17" "9" "10" "9" "521" "57.0" "8.46" "31.37" "9" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "Base excision repair; DNA repair pathways, full network" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "3" "0" "1.055" "0.850" "1.134" "1.159" "0.941" "1.036" "1.006" "0.924" "1.027" "356.6" "376.1" "303.2" "404.5" "413.3" "335.6" "369.6" "358.6" "329.4" "366.1" "" "" "" "" "" "" "" "" "" "" "356.6" "318.2" "191.7" "295.0" "338.6" "260.6" "284.9" "308.4" "257.1" "329.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "27.480" "18" "5" "10" "5" "313" "35.7" "7.01" "34.65" "5" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "9" "0" "1.121" "0.872" "1.018" "1.082" "0.972" "1.044" "1.141" "0.939" "1.025" "313.4" "351.2" "273.1" "319.0" "339.1" "304.5" "327.2" "357.4" "294.3" "321.1" "" "" "" "" "" "" "" "" "" "" "313.4" "297.1" "172.7" "232.6" "277.8" "236.5" "252.2" "307.3" "229.7" "288.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "27.417" "25" "5" "11" "3" "208" "22.8" "5.73" "26.53" "5" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Ciliary landscape" "Smooth Muscle Contraction" "2" "0" "1.065" "0.909" "1.010" "1.088" "1.229" "1.199" "1.041" "1.004" "1.010" "202.0" "215.2" "183.6" "204.1" "219.8" "248.2" "242.1" "210.3" "202.8" "204.1" "" "" "" "" "" "" "" "" "" "" "202.0" "182.1" "116.1" "148.8" "180.1" "192.8" "186.6" "180.8" "158.3" "183.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "27.389" "25" "4" "6" "2" "215" "23.6" "8.15" "23.20" "4" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "16" "0" "1.141" "1.046" "1.103" "1.191" "1.112" "1.077" "1.102" "1.151" "0.988" "163.8" "186.9" "171.3" "180.8" "195.2" "182.3" "176.4" "180.6" "188.5" "161.9" "" "" "" "" "" "" "" "" "" "" "163.8" "158.2" "108.3" "131.8" "159.9" "141.5" "136.0" "155.3" "147.1" "145.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "27.388" "36" "7" "16" "7" "168" "19.7" "8.43" "49.09" "7" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.963" "0.998" "0.954" "0.865" "0.979" "0.889" "0.894" "0.979" "0.979" "924.9" "890.7" "923.4" "882.4" "799.7" "905.2" "822.6" "827.1" "905.6" "905.3" "" "" "" "" "" "" "" "" "" "" "924.9" "753.5" "583.9" "643.4" "655.2" "702.9" "634.1" "711.1" "706.8" "813.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "27.375" "14" "3" "10" "3" "230" "24.7" "6.77" "34.11" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "" "RAS processing; eNOS activation" "2" "0" "1.004" "1.007" "1.010" "0.976" "1.045" "1.012" "1.003" "1.108" "1.030" "288.6" "289.6" "290.5" "291.3" "281.6" "301.5" "292.1" "289.6" "319.8" "297.2" "" "" "" "" "" "" "" "" "" "" "288.6" "245.0" "183.7" "212.4" "230.7" "234.1" "225.2" "249.0" "249.6" "267.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "27.373" "45" "4" "7" "4" "150" "17.1" "4.68" "26.44" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "1.054" "0.914" "1.075" "1.021" "0.965" "1.028" "0.970" "0.981" "0.981" "491.1" "517.9" "448.7" "528.2" "501.5" "473.8" "504.8" "476.4" "481.9" "481.7" "" "" "" "" "" "" "" "" "" "" "491.1" "438.1" "283.7" "385.2" "410.9" "368.0" "389.1" "409.6" "376.1" "433.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "27.369" "5" "6" "7" "5" "1127" "122.5" "6.67" "22.57" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Ectoderm differentiation" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "3" "1" "1.087" "0.987" "0.981" "0.973" "1.034" "1.060" "1.106" "0.997" "0.992" "503.7" "547.3" "497.0" "494.0" "490.1" "520.9" "533.9" "557.2" "502.0" "499.9" "" "" "" "" "" "" "" "" "" "" "503.7" "463.0" "314.2" "360.2" "401.6" "404.5" "411.5" "479.1" "391.8" "449.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "27.360" "9" "6" "7" "6" "706" "80.2" "6.70" "23.88" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.061" "0.953" "1.144" "1.141" "1.042" "1.235" "1.093" "1.016" "1.085" "263.0" "279.0" "250.8" "300.9" "300.0" "274.0" "324.8" "287.5" "267.3" "285.4" "" "" "" "" "" "" "" "" "" "" "263.0" "236.0" "158.6" "219.4" "245.8" "212.8" "250.4" "247.2" "208.7" "256.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "27.358" "10" "6" "6" "6" "673" "73.7" "8.98" "22.01" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.134" "0.703" "1.079" "1.118" "0.786" "1.047" "1.070" "0.824" "0.936" "260.6" "295.6" "183.3" "281.3" "291.3" "204.9" "272.9" "278.9" "214.7" "244.0" "" "" "" "" "" "" "" "" "" "" "260.6" "250.0" "115.9" "205.1" "238.7" "159.1" "210.3" "239.8" "167.6" "219.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "27.305" "21" "8" "13" "8" "348" "37.9" "7.23" "37.47" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "" "Purine salvage" "1" "0" "1.013" "1.066" "0.941" "0.984" "1.130" "0.964" "1.000" "1.061" "1.066" "575.8" "583.2" "613.9" "541.9" "566.4" "650.6" "554.8" "576.0" "610.8" "613.9" "" "" "" "" "" "" "" "" "" "" "575.8" "493.4" "388.2" "395.1" "464.1" "505.2" "427.6" "495.2" "476.8" "552.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "27.268" "32" "3" "8" "3" "100" "10.7" "9.60" "31.20" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "8" "0" "1.024" "1.194" "0.943" "1.012" "1.055" "1.040" "0.849" "1.053" "1.077" "725.9" "743.3" "866.7" "684.4" "734.5" "765.8" "755.2" "616.6" "764.4" "781.5" "" "" "" "" "" "" "" "" "" "" "725.9" "628.8" "548.0" "499.0" "601.8" "594.7" "582.2" "530.2" "596.6" "702.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "27.263" "30" "8" "11" "8" "250" "28.7" "8.75" "28.40" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.069" "1.042" "1.023" "1.104" "1.072" "1.001" "1.033" "1.070" "1.026" "796.1" "851.1" "829.2" "814.2" "878.7" "853.1" "797.0" "822.7" "851.5" "816.5" "" "" "" "" "" "" "" "" "" "" "796.1" "720.1" "524.3" "593.6" "719.9" "662.5" "614.4" "707.3" "664.7" "734.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "27.254" "13" "5" "11" "3" "386" "42.9" "7.74" "35.93" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "" "FGFR2 alternative splicing" "1" "3" "1.064" "1.116" "1.045" "1.090" "1.115" "0.947" "1.028" "1.115" "1.118" "601.7" "640.3" "671.6" "628.7" "656.0" "671.1" "569.6" "618.5" "671.0" "672.9" "" "" "" "" "" "" "" "" "" "" "601.7" "541.7" "424.6" "458.4" "537.4" "521.2" "439.1" "531.8" "523.8" "605.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "27.242" "25" "5" "14" "5" "227" "26.3" "6.34" "50.16" "5" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "11" "0" "1.011" "0.979" "0.928" "0.951" "0.853" "0.867" "0.853" "0.921" "1.023" "741.4" "749.3" "726.1" "688.1" "705.3" "632.6" "642.8" "632.7" "682.6" "758.2" "" "" "" "" "" "" "" "" "" "" "741.4" "633.9" "459.1" "501.7" "577.8" "491.3" "495.5" "544.0" "532.8" "681.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "27.191" "11" "7" "10" "6" "606" "64.9" "9.32" "32.38" "7" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "" "Platelet degranulation" "1" "0" "0.987" "0.813" "1.005" "1.058" "0.830" "1.029" "1.033" "0.843" "0.890" "466.4" "460.5" "379.2" "468.8" "493.6" "386.9" "479.7" "481.6" "393.2" "414.9" "" "" "" "" "" "" "" "" "" "" "466.4" "389.6" "239.8" "341.8" "404.4" "300.5" "369.8" "414.1" "306.9" "373.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "27.191" "7" "7" "7" "7" "1235" "142.6" "5.15" "23.91" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "TAR syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "4" "0" "1.035" "1.027" "1.080" "1.014" "1.133" "1.077" "1.009" "1.027" "1.049" "267.8" "277.1" "275.0" "289.3" "271.4" "303.3" "288.5" "270.2" "275.1" "281.1" "" "" "" "" "" "" "" "" "" "" "267.8" "234.4" "173.9" "211.0" "222.4" "235.6" "222.4" "232.3" "214.7" "252.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "27.190" "14" "5" "8" "5" "398" "45.5" "8.88" "26.91" "5" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.934" "0.909" "0.972" "1.041" "0.851" "1.029" "0.986" "0.805" "0.999" "147.0" "137.3" "133.7" "142.9" "153.1" "125.0" "151.2" "144.9" "118.3" "146.9" "" "" "" "" "" "" "" "" "" "" "147.0" "116.2" "84.5" "104.2" "125.4" "97.1" "116.6" "124.5" "92.4" "132.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "27.166" "30" "5" "8" "3" "215" "23.7" "8.13" "25.80" "5" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "9" "0" "1.085" "1.064" "1.085" "0.945" "0.982" "0.988" "1.047" "1.017" "1.024" "261.4" "283.7" "278.1" "283.7" "247.0" "256.6" "258.3" "273.8" "266.0" "267.8" "" "" "" "" "" "" "" "" "" "" "261.4" "240.0" "175.8" "206.9" "202.4" "199.3" "199.1" "235.4" "207.6" "240.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "27.137" "17" "6" "9" "6" "387" "44.7" "5.60" "31.83" "6" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "0.983" "0.801" "0.914" "1.000" "0.858" "0.988" "0.988" "0.844" "0.963" "660.2" "649.1" "529.1" "603.4" "660.0" "566.2" "652.0" "652.2" "557.0" "636.0" "" "" "" "" "" "" "" "" "" "" "660.2" "549.1" "334.6" "439.9" "540.8" "439.7" "502.6" "560.7" "434.8" "571.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "27.106" "9" "5" "8" "5" "637" "72.7" "6.09" "28.45" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "17" "0" "0.937" "1.098" "0.999" "1.043" "1.094" "1.006" "1.023" "1.024" "1.026" "415.6" "389.5" "456.4" "415.0" "433.5" "454.8" "417.9" "425.1" "425.8" "426.5" "" "" "" "" "" "" "" "" "" "" "415.6" "329.5" "288.6" "302.6" "355.2" "353.2" "322.2" "365.5" "332.3" "383.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "27.093" "7" "8" "8" "8" "1186" "131.6" "7.20" "26.88" "8" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.127" "1.118" "1.134" "1.157" "1.150" "1.134" "1.139" "1.166" "1.140" "288.2" "324.8" "322.2" "326.7" "333.4" "331.5" "326.8" "328.1" "336.0" "328.4" "" "" "" "" "" "" "" "" "" "" "288.2" "274.8" "203.7" "238.2" "273.1" "257.5" "251.9" "282.1" "262.3" "295.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "27.079" "29" "3" "10" "3" "134" "15.3" "4.53" "34.62" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.995" "1.047" "1.134" "1.102" "1.108" "1.325" "1.004" "1.051" "1.010" "513.0" "510.3" "536.9" "581.6" "565.4" "568.4" "679.8" "515.3" "539.5" "518.1" "" "" "" "" "" "" "" "" "" "" "513.0" "431.7" "339.5" "424.0" "463.2" "441.4" "524.0" "443.0" "421.1" "465.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "27.063" "23" "5" "12" "5" "224" "25.2" "9.28" "40.86" "5" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "1.032" "1.089" "0.970" "1.069" "1.020" "1.021" "0.927" "1.066" "1.047" "642.0" "662.3" "699.3" "622.4" "686.5" "654.9" "655.2" "594.9" "684.6" "672.3" "" "" "" "" "" "" "" "" "" "" "642.0" "560.4" "442.2" "453.8" "562.5" "508.6" "505.1" "511.5" "534.4" "604.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "27.015" "24" "4" "11" "4" "172" "19.6" "4.93" "33.94" "4" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.986" "1.121" "0.950" "1.049" "1.027" "1.059" "1.079" "1.028" "1.007" "735.8" "725.7" "825.2" "698.7" "771.8" "755.9" "779.3" "793.7" "756.1" "740.8" "" "" "" "" "" "" "" "" "" "" "735.8" "614.0" "521.8" "509.5" "632.3" "587.0" "600.7" "682.4" "590.2" "666.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1171297253546326275" "False" "High" "IsMasterProtein" "Q6AI08" "HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1" "0.000" "False" "26.977" "6" "5" "5" "5" "1181" "128.7" "7.03" "18.73" "5" "" "" "" "Pf13251" "63897" "ENSG00000068097" "HEATR6" "B3KXP3; hsa:63897; Q6AI08; Q6MZX1; Q6MZY2; Q8TDM9; Q9H6B3; Q9H6M7" "" "" "0" "0" "0.969" "0.731" "0.965" "0.860" "0.817" "0.945" "0.906" "0.812" "0.940" "201.0" "194.7" "146.9" "194.0" "172.8" "164.2" "189.9" "182.0" "163.3" "189.0" "" "" "" "" "" "" "" "" "" "" "201.0" "164.8" "92.9" "141.5" "141.5" "127.5" "146.4" "156.5" "127.4" "169.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "26.931" "21" "6" "8" "6" "303" "33.8" "7.11" "24.63" "6" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Lysosome Vesicle Biogenesis; COPII-mediated vesicle transport; Cargo concentration in the ER" "5" "0" "1.018" "1.056" "1.009" "1.013" "1.042" "1.072" "1.061" "1.080" "1.113" "485.8" "494.6" "513.2" "490.0" "492.1" "506.1" "521.0" "515.3" "524.5" "540.9" "" "" "" "" "" "" "" "" "" "" "485.8" "418.4" "324.5" "357.3" "403.1" "393.1" "401.6" "443.1" "409.4" "486.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6713486079386730204" "False" "High" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "0.000" "False" "26.819" "16" "6" "6" "6" "418" "46.4" "8.69" "22.78" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "Collagen biosynthesis and modifying enzymes" "6" "0" "0.959" "0.989" "0.858" "0.984" "1.036" "1.014" "1.043" "0.983" "0.997" "386.3" "370.5" "382.2" "331.3" "380.2" "400.4" "391.8" "402.8" "379.7" "385.3" "" "" "" "" "" "" "" "" "" "" "386.3" "313.5" "241.6" "241.5" "311.5" "310.9" "302.0" "346.4" "296.4" "346.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "26.815" "37" "5" "7" "5" "172" "19.7" "5.00" "23.82" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "13" "0" "1.093" "0.957" "1.085" "1.330" "1.146" "1.339" "1.129" "0.916" "1.021" "186.0" "203.4" "178.1" "201.7" "247.4" "213.1" "249.1" "210.1" "170.4" "189.9" "" "" "" "" "" "" "" "" "" "" "186.0" "172.1" "112.6" "147.1" "202.7" "165.5" "192.0" "180.6" "133.0" "170.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "26.806" "10" "8" "10" "8" "841" "95.9" "5.11" "28.71" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "1.080" "0.953" "1.106" "1.190" "1.025" "1.211" "1.123" "1.021" "1.048" "639.1" "690.0" "608.8" "707.1" "760.4" "654.8" "773.7" "717.6" "652.7" "669.6" "" "" "" "" "" "" "" "" "" "" "639.1" "583.7" "385.0" "515.6" "623.0" "508.5" "596.4" "617.0" "509.5" "602.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "26.789" "13" "3" "7" "3" "262" "29.3" "9.79" "24.98" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "" "Mitochondrial translation termination" "1" "0" "0.965" "1.140" "1.081" "1.145" "1.207" "1.107" "1.058" "1.169" "1.084" "355.2" "342.8" "404.9" "383.9" "406.6" "428.7" "393.1" "375.6" "415.2" "385.1" "" "" "" "" "" "" "" "" "" "" "355.2" "290.1" "256.0" "279.9" "333.1" "332.9" "303.0" "323.0" "324.1" "346.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "26.780" "9" "5" "9" "5" "557" "64.1" "5.08" "28.75" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "3" "0" "1.003" "0.955" "1.018" "1.006" "1.130" "0.976" "1.014" "1.007" "1.091" "344.9" "345.9" "329.4" "351.2" "346.9" "389.9" "336.5" "349.8" "347.3" "376.3" "" "" "" "" "" "" "" "" "" "" "344.9" "292.7" "208.3" "256.1" "284.2" "302.8" "259.4" "300.7" "271.1" "338.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "26.771" "21" "5" "8" "1" "219" "21.9" "11.03" "26.29" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Pathways affected in adenoid cystic carcinoma" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "3" "1" "0.893" "0.687" "0.934" "0.928" "0.734" "0.886" "1.017" "0.682" "0.946" "245.8" "219.5" "168.9" "229.6" "228.2" "180.3" "217.9" "250.0" "167.7" "232.6" "" "" "" "" "" "" "" "" "" "" "245.8" "185.7" "106.8" "167.4" "186.9" "140.0" "168.0" "214.9" "130.9" "209.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486403724056782188" "False" "High" "IsMasterProtein" "Q7L8L6" "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" "0.000" "False" "26.760" "9" "6" "7" "6" "764" "86.5" "8.13" "26.27" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "60493" "ENSG00000215251" "FASTKD5" "hsa:60493; Q7L8L6; Q96JN3; Q9H5D1; Q9H8Y3" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.031" "0.861" "1.077" "1.052" "0.889" "1.005" "1.104" "0.932" "0.917" "175.2" "180.6" "150.8" "188.7" "184.2" "155.6" "176.0" "193.4" "163.2" "160.7" "" "" "" "" "" "" "" "" "" "" "175.2" "152.8" "95.4" "137.6" "150.9" "120.9" "135.7" "166.3" "127.4" "144.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "26.702" "11" "7" "12" "7" "608" "65.8" "6.73" "42.34" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "Estrogen-dependent gene expression; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "15" "0" "0.973" "0.958" "0.995" "0.917" "0.932" "0.951" "0.996" "0.936" "0.998" "882.6" "858.8" "845.9" "878.4" "809.6" "822.3" "839.1" "878.6" "825.6" "880.6" "" "" "" "" "" "" "" "" "" "" "882.6" "726.6" "534.9" "640.5" "663.3" "638.6" "646.8" "755.4" "644.5" "791.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "26.687" "24" "9" "12" "9" "374" "39.7" "7.49" "37.41" "9" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "Ethanol oxidation" "3" "0" "1.018" "0.978" "0.970" "0.901" "0.905" "0.815" "0.902" "0.975" "0.941" "650.5" "662.3" "636.2" "631.0" "585.8" "588.5" "530.0" "586.5" "634.3" "611.8" "" "" "" "" "" "" "" "" "" "" "650.5" "560.3" "402.3" "460.1" "479.9" "457.0" "408.5" "504.3" "495.1" "550.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "26.652" "17" "7" "9" "7" "398" "46.4" "5.54" "29.39" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "2q37 copy number variation syndrome" "Intra-Golgi traffic" "2" "0" "0.971" "0.826" "1.074" "1.150" "0.916" "1.037" "1.161" "0.961" "0.988" "298.5" "289.8" "246.6" "320.5" "343.1" "273.4" "309.4" "346.4" "286.9" "295.0" "" "" "" "" "" "" "" "" "" "" "298.5" "245.1" "155.9" "233.7" "281.1" "212.3" "238.5" "297.8" "223.9" "265.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "26.650" "20" "6" "8" "6" "331" "37.5" "8.34" "29.67" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "" "Neutrophil degranulation; MHC class II antigen presentation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "6" "0" "0.922" "1.057" "0.948" "0.926" "1.035" "0.872" "0.967" "0.943" "1.014" "504.9" "465.7" "533.9" "478.9" "467.3" "522.8" "440.2" "488.1" "476.4" "511.7" "" "" "" "" "" "" "" "" "" "" "504.9" "394.0" "337.6" "349.2" "382.9" "406.0" "339.3" "419.7" "371.8" "460.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "26.626" "53" "4" "9" "4" "86" "10.2" "7.05" "32.31" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "7" "0" "1.013" "0.751" "0.963" "1.033" "0.811" "1.232" "1.023" "0.766" "0.926" "716.6" "725.7" "537.9" "690.3" "740.5" "581.2" "882.6" "732.8" "549.2" "663.8" "" "" "" "" "" "" "" "" "" "" "716.6" "613.9" "340.1" "503.3" "606.7" "451.4" "680.3" "630.0" "428.7" "596.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3455107625301328378" "False" "High" "IsMasterProtein" "Q86TX2" "Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1" "0.000" "False" "26.622" "18" "7" "10" "7" "421" "46.2" "7.34" "31.44" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf04775, Pf08840" "641371" "ENSG00000184227" "ACOT1" "A1L173; hsa:641371; Q3I5F9; Q86TX2" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.058" "1.129" "0.999" "1.081" "1.131" "0.967" "1.070" "1.160" "1.080" "216.2" "228.7" "244.1" "215.9" "233.8" "244.5" "209.0" "231.4" "250.9" "233.6" "" "" "" "" "" "" "" "" "" "" "216.2" "193.5" "154.3" "157.4" "191.5" "189.9" "161.1" "199.0" "195.8" "210.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.000" "False" "26.609" "14" "7" "7" "7" "462" "50.5" "5.92" "23.11" "7" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "2" "0" "0.935" "0.645" "0.961" "0.932" "0.756" "0.884" "0.993" "0.794" "0.838" "254.9" "238.2" "164.4" "244.9" "237.4" "192.7" "225.2" "253.1" "202.4" "213.7" "" "" "" "" "" "" "" "" "" "" "254.9" "201.5" "103.9" "178.5" "194.5" "149.6" "173.6" "217.6" "158.0" "192.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "26.592" "8" "7" "11" "6" "1008" "114.7" "7.68" "24.88" "7" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "VEGFA-VEGFR2 signaling" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "2" "0" "1.037" "0.983" "1.095" "1.037" "0.971" "0.946" "1.066" "1.010" "1.027" "354.8" "368.0" "348.6" "388.3" "367.8" "344.7" "335.7" "378.3" "358.3" "364.3" "" "" "" "" "" "" "" "" "" "" "354.8" "311.3" "220.4" "283.1" "301.3" "267.7" "258.8" "325.3" "279.6" "327.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.000" "False" "26.558" "12" "3" "5" "2" "276" "31.1" "6.95" "20.23" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "" "Glycolysis" "1" "0" "1.046" "1.120" "0.901" "0.993" "1.044" "0.969" "0.964" "1.061" "1.153" "263.4" "275.5" "295.1" "237.4" "261.5" "275.1" "255.2" "254.0" "279.4" "303.5" "" "" "" "" "" "" "" "" "" "" "263.4" "233.1" "186.6" "173.1" "214.3" "213.6" "196.7" "218.4" "218.1" "272.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "26.535" "7" "6" "7" "6" "985" "108.1" "8.32" "23.12" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "" "2" "0" "0.915" "0.866" "1.095" "1.015" "0.969" "1.022" "1.174" "0.791" "0.966" "164.8" "150.8" "142.8" "180.5" "167.3" "159.7" "168.5" "193.6" "130.4" "159.3" "" "" "" "" "" "" "" "" "" "" "164.8" "127.5" "90.3" "131.6" "137.1" "124.0" "129.9" "166.5" "101.8" "143.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "26.522" "26" "5" "7" "5" "254" "28.6" "5.00" "23.97" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "16" "0" "0.966" "1.218" "1.036" "1.036" "1.239" "1.062" "1.058" "1.146" "1.084" "390.7" "377.5" "475.9" "404.8" "404.9" "484.0" "414.8" "413.5" "448.0" "423.6" "" "" "" "" "" "" "" "" "" "" "390.7" "319.3" "300.9" "295.1" "331.7" "375.9" "319.7" "355.5" "349.7" "380.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "26.513" "15" "9" "12" "9" "475" "51.8" "7.85" "37.41" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.049" "1.105" "1.091" "1.052" "1.174" "1.070" "1.085" "1.146" "1.122" "808.0" "847.8" "892.7" "881.9" "849.8" "948.9" "864.7" "876.4" "926.3" "906.2" "" "" "" "" "" "" "" "" "" "" "808.0" "717.3" "564.5" "643.0" "696.3" "736.9" "666.5" "753.5" "723.0" "814.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "26.502" "30" "4" "5" "3" "180" "20.3" "6.35" "19.20" "4" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.072" "0.885" "1.221" "1.115" "0.940" "1.091" "1.136" "0.833" "0.954" "144.4" "154.8" "127.7" "176.3" "161.0" "135.8" "157.6" "164.0" "120.3" "137.8" "" "" "" "" "" "" "" "" "" "" "144.4" "131.0" "80.8" "128.6" "131.9" "105.4" "121.5" "141.0" "93.9" "123.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1527635989384521277" "False" "High" "IsMasterProtein" "Q13367" "AP-3 complex subunit beta-2 OS=Homo sapiens OX=9606 GN=AP3B2 PE=1 SV=2" "0.000" "False" "26.471" "6" "5" "5" "2" "1082" "119.0" "5.59" "18.03" "5" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf14796" "8120" "ENSG00000103723" "AP3B2" "A4Z4T7; B7ZKR7; B7ZKS0; O14808; Q13367; Q52LY8" "15q25 copy number variation" "" "1" "0" "0.977" "1.085" "1.079" "1.246" "1.104" "1.056" "1.062" "1.209" "1.124" "70.9" "69.3" "76.9" "76.5" "88.3" "78.3" "74.9" "75.3" "85.8" "79.7" "" "" "" "" "" "" "" "" "" "" "70.9" "58.6" "48.6" "55.8" "72.4" "60.8" "57.7" "64.7" "66.9" "71.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "26.469" "4" "8" "9" "8" "2039" "229.3" "6.96" "24.65" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "0.982" "1.115" "1.023" "1.110" "1.152" "1.129" "1.061" "1.035" "1.011" "195.5" "192.0" "218.0" "200.0" "216.9" "225.2" "220.7" "207.5" "202.4" "197.7" "" "" "" "" "" "" "" "" "" "" "195.5" "162.4" "137.8" "145.8" "177.7" "174.9" "170.1" "178.4" "158.0" "177.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "26.458" "15" "7" "10" "7" "529" "59.5" "8.92" "28.02" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "3" "0" "1.045" "1.010" "1.179" "1.027" "1.007" "1.160" "1.130" "0.921" "1.078" "120.3" "125.7" "121.5" "141.9" "123.5" "121.2" "139.6" "136.0" "110.8" "129.7" "" "" "" "" "" "" "" "" "" "" "120.3" "106.3" "76.8" "103.4" "101.2" "94.1" "107.6" "116.9" "86.5" "116.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "26.434" "14" "6" "9" "3" "443" "49.3" "5.69" "29.09" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "" "Apoptotic cleavage of cellular proteins" "2" "0" "0.954" "1.098" "0.867" "0.875" "0.927" "0.853" "0.871" "0.923" "0.876" "417.6" "398.5" "458.4" "362.1" "365.3" "387.2" "356.2" "363.8" "385.4" "366.0" "" "" "" "" "" "" "" "" "" "" "417.6" "337.1" "289.8" "264.0" "299.3" "300.7" "274.6" "312.8" "300.9" "329.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1820154667624248039" "False" "High" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "0.000" "False" "26.414" "8" "8" "8" "8" "1239" "139.5" "6.90" "25.93" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "Male infertility; Primary ovarian insufficiency" "" "2" "0" "1.108" "1.033" "0.977" "1.055" "1.049" "1.067" "1.117" "1.010" "1.087" "352.0" "390.0" "363.5" "343.7" "371.2" "369.1" "375.6" "393.3" "355.5" "382.5" "" "" "" "" "" "" "" "" "" "" "352.0" "330.0" "229.8" "250.6" "304.1" "286.6" "289.5" "338.2" "277.5" "343.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "26.384" "12" "4" "10" "4" "350" "40.1" "8.28" "33.91" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "Platelet degranulation" "4" "0" "1.002" "0.876" "0.925" "0.905" "0.773" "0.823" "0.905" "0.854" "0.808" "882.1" "884.2" "772.9" "815.6" "798.0" "681.5" "725.7" "798.6" "753.2" "713.1" "" "" "" "" "" "" "" "" "" "" "882.1" "748.1" "488.7" "594.7" "653.8" "529.2" "559.4" "686.7" "587.9" "641.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "26.359" "11" "4" "6" "4" "432" "47.5" "6.99" "20.70" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Valproic acid pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "3" "0" "0.884" "0.965" "0.931" "0.894" "1.075" "0.945" "0.952" "1.000" "0.999" "253.6" "224.2" "244.7" "236.1" "226.8" "272.7" "239.8" "241.4" "253.6" "253.4" "" "" "" "" "" "" "" "" "" "" "253.6" "189.7" "154.7" "172.2" "185.9" "211.8" "184.8" "207.6" "198.0" "227.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "26.300" "32" "6" "9" "6" "205" "23.5" "5.08" "24.64" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "13" "0" "1.038" "0.955" "1.060" "1.045" "0.922" "1.012" "1.014" "0.845" "1.091" "264.0" "274.2" "252.1" "279.8" "275.9" "243.3" "267.2" "267.8" "223.1" "288.0" "" "" "" "" "" "" "" "" "" "" "264.0" "231.9" "159.4" "204.0" "226.0" "189.0" "206.0" "230.3" "174.1" "258.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "26.275" "15" "5" "7" "5" "332" "37.5" "8.40" "24.54" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.216" "1.030" "1.131" "1.118" "1.039" "1.101" "1.096" "1.082" "1.121" "389.7" "473.7" "401.5" "440.6" "435.8" "404.8" "429.1" "427.3" "421.6" "436.9" "" "" "" "" "" "" "" "" "" "" "389.7" "400.8" "253.9" "321.2" "357.0" "314.3" "330.7" "367.4" "329.1" "392.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "26.240" "22" "10" "16" "9" "418" "47.3" "5.21" "42.81" "10" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Assembly of the pre-replicative complex; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.068" "1.061" "1.088" "1.113" "1.003" "1.062" "1.082" "0.980" "1.055" "649.5" "693.8" "689.3" "706.7" "722.6" "651.6" "689.5" "703.0" "636.6" "685.3" "" "" "" "" "" "" "" "" "" "" "649.5" "587.0" "435.8" "515.3" "592.0" "506.0" "531.5" "604.5" "496.9" "616.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "26.225" "26" "6" "10" "6" "231" "25.7" "6.84" "30.15" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "0.823" "0.936" "1.015" "0.844" "1.005" "1.101" "0.767" "0.935" "0.896" "292.3" "240.5" "273.7" "296.9" "246.6" "293.9" "321.8" "224.2" "273.5" "261.8" "" "" "" "" "" "" "" "" "" "" "292.3" "203.5" "173.1" "216.5" "202.1" "228.3" "248.0" "192.7" "213.5" "235.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "26.213" "15" "7" "7" "7" "497" "56.6" "6.65" "22.82" "7" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "TNFR1-induced NF-kappa-B signaling pathway; Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "20" "0" "1.080" "0.898" "1.019" "1.028" "0.957" "1.119" "1.065" "0.916" "1.014" "385.2" "416.0" "346.0" "392.4" "396.1" "368.7" "431.1" "410.4" "352.8" "390.5" "" "" "" "" "" "" "" "" "" "" "385.2" "351.9" "218.8" "286.1" "324.5" "286.3" "332.3" "352.9" "275.4" "351.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "26.197" "12" "5" "7" "5" "493" "54.5" "6.00" "26.82" "5" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "1.039" "1.027" "0.955" "0.980" "1.050" "1.001" "0.986" "1.053" "0.966" "523.4" "543.5" "537.5" "500.0" "512.8" "549.4" "523.8" "515.8" "551.0" "505.6" "" "" "" "" "" "" "" "" "" "" "523.4" "459.8" "339.9" "364.6" "420.1" "426.6" "403.8" "443.5" "430.1" "454.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "26.186" "15" "6" "8" "6" "427" "47.7" "11.06" "25.37" "6" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.916" "1.293" "1.122" "1.081" "1.439" "1.115" "1.195" "1.448" "1.092" "275.2" "252.1" "356.0" "308.8" "297.6" "396.1" "306.8" "328.9" "398.5" "300.6" "" "" "" "" "" "" "" "" "" "" "275.2" "213.3" "225.1" "225.1" "243.8" "307.6" "236.5" "282.8" "311.0" "270.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "26.177" "19" "5" "11" "5" "239" "25.3" "4.92" "34.70" "5" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.032" "1.186" "1.083" "1.045" "1.132" "1.112" "1.068" "1.116" "1.066" "792.8" "817.8" "940.4" "859.0" "828.8" "897.3" "881.4" "847.1" "884.4" "845.1" "" "" "" "" "" "" "" "" "" "" "792.8" "691.9" "594.6" "626.3" "679.1" "696.9" "679.4" "728.4" "690.3" "759.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "26.151" "39" "4" "7" "4" "87" "10.1" "6.04" "25.30" "4" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "" "Mitochondrial protein import" "1" "0" "1.003" "0.964" "1.099" "1.195" "0.926" "1.200" "1.146" "1.018" "1.023" "257.4" "258.1" "248.1" "283.0" "307.5" "238.3" "308.8" "295.0" "262.0" "263.4" "" "" "" "" "" "" "" "" "" "" "257.4" "218.3" "156.9" "206.3" "251.9" "185.1" "238.0" "253.6" "204.5" "236.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "26.137" "14" "5" "6" "5" "469" "51.7" "5.21" "22.79" "5" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "1.067" "1.020" "1.127" "1.094" "1.006" "1.070" "1.122" "0.962" "1.027" "461.3" "492.4" "470.6" "519.7" "504.6" "464.0" "493.8" "517.6" "443.9" "473.7" "" "" "" "" "" "" "" "" "" "" "461.3" "416.6" "297.6" "379.0" "413.4" "360.4" "380.7" "445.1" "346.5" "425.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "26.105" "9" "6" "9" "6" "906" "99.6" "6.54" "25.16" "6" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Spry regulation of FGF signaling; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "39" "0" "1.102" "0.989" "1.162" "0.980" "1.050" "1.127" "1.051" "0.982" "1.050" "216.3" "238.4" "214.0" "251.4" "212.0" "227.0" "243.8" "227.3" "212.4" "227.1" "" "" "" "" "" "" "" "" "" "" "216.3" "201.7" "135.3" "183.3" "173.7" "176.3" "187.9" "195.4" "165.8" "204.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "26.070" "11" "3" "9" "3" "297" "33.1" "5.05" "31.29" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "" "2" "0" "0.957" "0.997" "1.088" "1.034" "0.922" "1.027" "1.023" "0.948" "1.038" "538.3" "515.1" "536.6" "585.4" "556.4" "496.6" "552.9" "550.7" "510.4" "558.6" "" "" "" "" "" "" "" "" "" "" "538.3" "435.8" "339.3" "426.9" "455.9" "385.6" "426.2" "473.5" "398.4" "502.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "26.037" "17" "7" "10" "7" "423" "46.3" "8.13" "36.00" "7" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.959" "1.040" "0.995" "1.011" "1.057" "0.970" "0.977" "1.057" "1.024" "660.2" "633.4" "686.7" "657.1" "667.7" "697.8" "640.3" "645.0" "698.1" "676.3" "" "" "" "" "" "" "" "" "" "" "660.2" "535.9" "434.2" "479.2" "547.1" "541.9" "493.6" "554.6" "544.9" "608.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4225597047578388345" "False" "High" "IsMasterProtein" "Q9H334" "Forkhead box protein P1 OS=Homo sapiens OX=9606 GN=FOXP1 PE=1 SV=1" "0.000" "False" "26.028" "9" "5" "6" "5" "677" "75.3" "6.67" "19.82" "5" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "27086" "ENSG00000114861" "FOXP1" "A3QVP8; B3KV70; G5E9V8; hsa:27086; Q8NAN6; Q9BSG9; Q9H332; Q9H333; Q9H334; Q9P0R1" "" "" "0" "0" "0.893" "0.811" "0.882" "0.912" "0.834" "0.713" "0.899" "0.762" "0.934" "57.5" "51.3" "46.6" "50.7" "52.4" "47.9" "41.0" "51.7" "43.8" "53.7" "" "" "" "" "" "" "" "" "" "" "57.5" "43.4" "29.5" "37.0" "43.0" "37.2" "31.6" "44.4" "34.2" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "26.023" "26" "4" "5" "4" "215" "24.7" "8.51" "20.73" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "" "ER-Phagosome pathway; COPI-dependent Golgi-to-ER retrograde traffic; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.092" "1.459" "1.182" "1.152" "1.481" "1.020" "0.999" "1.557" "1.215" "244.3" "266.8" "356.5" "288.7" "281.4" "361.9" "249.3" "244.0" "380.3" "296.9" "" "" "" "" "" "" "" "" "" "" "244.3" "225.7" "225.4" "210.5" "230.6" "281.0" "192.2" "209.8" "296.9" "266.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574193745658390357" "False" "High" "IsMasterProtein" "P46926" "Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1" "0.000" "False" "26.003" "12" "3" "5" "2" "289" "32.6" "6.92" "17.51" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01182" "10007" "ENSG00000113552" "GNPDA1" "B7Z3X4; D3DQE7; hsa:10007; P46926" "" "Glycolysis" "1" "2" "1.046" "1.132" "1.017" "0.956" "1.050" "1.013" "1.050" "1.069" "1.041" "460.8" "481.9" "521.7" "468.7" "440.4" "483.7" "466.7" "484.1" "492.7" "479.6" "" "" "" "" "" "" "" "" "" "" "460.8" "407.7" "329.9" "341.8" "360.8" "375.6" "359.7" "416.2" "384.6" "431.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "25.992" "7" "3" "6" "3" "582" "63.2" "6.25" "15.93" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "TGF-beta signaling pathway" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "1.110" "0.882" "1.217" "1.013" "0.933" "0.949" "1.017" "0.938" "1.017" "99.0" "109.9" "87.4" "120.5" "100.3" "92.4" "93.9" "100.7" "92.9" "100.7" "" "" "" "" "" "" "" "" "" "" "99.0" "93.0" "55.3" "87.9" "82.2" "71.8" "72.4" "86.6" "72.5" "90.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "25.967" "27" "7" "12" "6" "270" "31.8" "6.55" "29.33" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "2" "0" "1.097" "1.059" "1.057" "0.969" "1.113" "0.979" "1.011" "1.020" "0.999" "197.7" "217.0" "209.4" "208.9" "191.7" "220.1" "193.5" "199.8" "201.6" "197.5" "" "" "" "" "" "" "" "" "" "" "197.7" "183.6" "132.4" "152.3" "157.0" "171.0" "149.1" "171.8" "157.4" "177.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000966759959030184" "False" "High" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "0.000" "False" "25.964" "9" "6" "7" "6" "617" "70.5" "6.71" "22.05" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "2" "0" "1.067" "0.950" "1.025" "1.062" "0.976" "1.116" "1.008" "0.951" "0.990" "305.2" "325.5" "290.0" "312.9" "324.1" "297.9" "340.5" "307.5" "290.3" "302.2" "" "" "" "" "" "" "" "" "" "" "305.2" "275.4" "183.4" "228.1" "265.6" "231.3" "262.4" "264.4" "226.6" "271.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "25.932" "30" "4" "6" "4" "182" "20.6" "4.92" "22.47" "4" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "1.054" "1.026" "0.973" "1.048" "1.242" "1.054" "1.001" "1.173" "0.984" "165.3" "174.1" "169.5" "160.8" "173.3" "205.2" "174.2" "165.5" "193.9" "162.6" "" "" "" "" "" "" "" "" "" "" "165.3" "147.3" "107.2" "117.2" "142.0" "159.4" "134.2" "142.3" "151.4" "146.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6346583217180848630" "False" "High" "IsMasterProtein" "P09601" "Heme oxygenase 1 OS=Homo sapiens OX=9606 GN=HMOX1 PE=1 SV=1" "0.000" "False" "25.921" "14" "3" "4" "3" "288" "32.8" "8.25" "15.03" "3" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01126" "3162" "ENSG00000100292" "HMOX1" "hsa:3162; P09601" "Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Overview of nanoparticle effects; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Lung fibrosis; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; IL-10 anti-inflammatory signaling pathway ; IL-18 signaling pathway; CAMKK2 pathway; Opioid receptor pathways; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Urotensin-II-mediated signaling pathway" "Heme signaling; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Cytoprotection by HMOX1; Interleukin-4 and Interleukin-13 signaling; Regulation of HMOX1 expression and activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Iron uptake and transport; Heme degradation" "25" "0" "1.002" "1.933" "1.081" "1.016" "1.751" "1.515" "0.977" "1.721" "1.360" "142.7" "142.9" "275.8" "154.3" "145.0" "249.9" "216.2" "139.4" "245.6" "194.1" "" "" "" "" "" "" "" "" "" "" "142.7" "120.9" "174.4" "112.5" "118.8" "194.1" "166.7" "119.8" "191.7" "174.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "25.901" "8" "4" "7" "2" "545" "60.6" "5.76" "23.77" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Generation of second messenger molecules; RHOQ GTPase cycle; RHOV GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "56" "0" "0.919" "1.030" "0.942" "1.013" "1.040" "0.953" "1.068" "0.956" "0.917" "178.4" "164.0" "183.7" "168.0" "180.7" "185.5" "169.9" "190.4" "170.4" "163.5" "" "" "" "" "" "" "" "" "" "" "178.4" "138.7" "116.2" "122.5" "148.0" "144.1" "131.0" "163.7" "133.0" "147.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "25.901" "19" "4" "11" "2" "201" "23.0" "8.29" "36.69" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "25.883" "22" "5" "8" "1" "213" "21.4" "10.93" "26.60" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8991968867262954800" "False" "High" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "0.000" "False" "25.867" "7" "11" "13" "11" "1649" "186.8" "6.28" "32.92" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Measles virus infection" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "2" "0" "1.073" "0.707" "1.024" "1.022" "0.836" "1.017" "0.983" "0.789" "0.985" "256.5" "275.2" "181.4" "262.5" "262.2" "214.4" "260.9" "252.1" "202.4" "252.6" "" "" "" "" "" "" "" "" "" "" "256.5" "232.8" "114.7" "191.4" "214.8" "166.5" "201.1" "216.8" "158.0" "227.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8446655200423982377" "False" "High" "IsMasterProtein" "Q8N4C8" "Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2" "0.000" "False" "25.849" "5" "6" "7" "4" "1332" "149.7" "7.85" "24.44" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "50488" "ENSG00000141503" "MINK1" "D3DTK3; D3DTK4; hsa:50488; Q5U8Z0; Q8N4C8; Q9P1X1; Q9P2R8" "Angiopoietin-like protein 8 regulatory pathway; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "5" "0" "1.181" "0.972" "1.145" "1.273" "1.163" "1.193" "1.088" "1.080" "1.095" "123.0" "145.3" "119.6" "140.9" "156.7" "143.1" "146.7" "133.9" "132.8" "134.7" "" "" "" "" "" "" "" "" "" "" "123.0" "122.9" "75.6" "102.7" "128.4" "111.1" "113.1" "115.1" "103.7" "121.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205660111365886564" "False" "High" "IsMasterProtein" "Q92599" "Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4" "0.000" "False" "25.839" "12" "6" "12" "4" "483" "55.7" "6.28" "30.09" "6" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23176" "ENSG00000164402" "SEPTIN8" "A6NC65; A6NKP6; F6W7K9; hsa:23176; Q8IX36; Q8IX37; Q92599; Q9BVB3" "22q11.2 copy number variation syndrome" "" "1" "0" "1.012" "1.167" "1.172" "1.091" "1.299" "1.144" "1.081" "1.186" "1.070" "148.0" "149.9" "172.8" "173.5" "161.6" "192.3" "169.4" "160.0" "175.6" "158.4" "" "" "" "" "" "" "" "" "" "" "148.0" "126.8" "109.3" "126.5" "132.4" "149.4" "130.6" "137.6" "137.0" "142.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "25.822" "18" "3" "10" "3" "209" "23.4" "8.24" "32.34" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "1.014" "0.999" "1.046" "1.096" "1.105" "1.113" "1.042" "1.137" "1.119" "246.8" "250.3" "246.7" "258.1" "270.6" "272.8" "274.7" "257.1" "280.7" "276.1" "" "" "" "" "" "" "" "" "" "" "246.8" "211.7" "156.0" "188.2" "221.7" "211.8" "211.8" "221.0" "219.1" "248.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "25.804" "29" "5" "15" "5" "198" "22.1" "5.30" "44.50" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "1.027" "1.000" "1.049" "1.018" "1.092" "1.090" "1.022" "0.969" "1.046" "480.6" "493.5" "480.8" "504.0" "489.2" "525.0" "523.9" "491.4" "465.8" "502.8" "" "" "" "" "" "" "" "" "" "" "480.6" "417.5" "304.0" "367.5" "400.8" "407.7" "403.8" "422.5" "363.6" "452.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "25.804" "11" "5" "9" "5" "553" "60.1" "6.64" "27.87" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.144" "1.062" "1.126" "1.177" "1.111" "1.236" "1.059" "1.112" "1.277" "108.8" "124.4" "115.5" "122.5" "128.0" "120.9" "134.5" "115.2" "120.9" "138.9" "" "" "" "" "" "" "" "" "" "" "108.8" "105.3" "73.1" "89.3" "104.9" "93.9" "103.6" "99.0" "94.4" "124.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "25.792" "40" "6" "8" "5" "172" "19.5" "6.34" "26.22" "6" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.026" "1.021" "0.964" "1.012" "1.031" "1.049" "1.073" "1.044" "1.108" "406.3" "416.7" "414.8" "391.6" "411.2" "418.9" "426.2" "435.9" "424.1" "450.0" "" "" "" "" "" "" "" "" "" "" "406.3" "352.5" "262.3" "285.5" "336.9" "325.3" "328.5" "374.8" "331.1" "404.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "25.786" "22" "8" "10" "8" "377" "42.3" "6.83" "26.38" "8" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.098" "1.055" "1.055" "0.913" "0.972" "0.952" "0.983" "1.131" "0.986" "368.1" "404.3" "388.3" "388.6" "336.2" "358.0" "350.6" "362.1" "416.4" "363.0" "" "" "" "" "" "" "" "" "" "" "368.1" "342.0" "245.5" "283.3" "275.4" "278.0" "270.2" "311.3" "325.0" "326.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "25.754" "5" "7" "9" "7" "1496" "163.7" "7.21" "26.02" "7" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.080" "0.967" "1.035" "1.000" "1.050" "1.113" "1.026" "0.956" "1.022" "470.4" "508.0" "454.7" "486.9" "470.4" "494.1" "523.3" "482.5" "449.5" "480.7" "" "" "" "" "" "" "" "" "" "" "470.4" "429.8" "287.5" "355.0" "385.4" "383.7" "403.4" "414.8" "350.8" "432.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "25.743" "24" "4" "8" "4" "169" "19.4" "8.81" "24.59" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "Metapathway biotransformation Phase I and II" "" "1" "0" "0.893" "0.958" "0.897" "0.942" "0.955" "0.927" "0.937" "0.917" "0.987" "525.8" "469.3" "504.0" "471.7" "495.4" "502.3" "487.7" "492.5" "482.3" "518.9" "" "" "" "" "" "" "" "" "" "" "525.8" "397.1" "318.7" "343.9" "405.9" "390.1" "375.9" "423.5" "376.5" "466.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "25.727" "12" "7" "8" "7" "542" "59.8" "6.25" "26.38" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Synthesis of UDP-N-acetyl-glucosamine" "3" "0" "1.061" "1.008" "0.949" "0.980" "0.970" "0.952" "0.954" "0.924" "0.962" "864.1" "916.8" "870.9" "820.4" "847.1" "837.8" "822.3" "824.4" "798.2" "831.1" "" "" "" "" "" "" "" "" "" "" "864.1" "775.6" "550.7" "598.2" "694.1" "650.6" "633.9" "708.8" "623.1" "747.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "25.710" "8" "6" "7" "5" "803" "90.0" "7.09" "22.91" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOV GTPase cycle; RHOU GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; RHOQ GTPase cycle; RHOJ GTPase cycle; Ephrin signaling; EGFR downregulation" "14" "0" "0.979" "1.009" "1.037" "0.987" "0.994" "1.009" "1.038" "0.961" "1.006" "414.8" "406.2" "418.6" "430.1" "409.5" "412.5" "418.5" "430.7" "398.6" "417.4" "" "" "" "" "" "" "" "" "" "" "414.8" "343.6" "264.7" "313.6" "335.5" "320.3" "322.6" "370.3" "311.2" "375.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8075154103448429091" "False" "High" "IsMasterProtein" "O94927" "HAUS augmin-like complex subunit 5 OS=Homo sapiens OX=9606 GN=HAUS5 PE=1 SV=2" "0.000" "False" "25.656" "11" "6" "6" "6" "633" "71.6" "8.51" "18.25" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14817" "23354" "ENSG00000249115" "HAUS5" "B2RXK1; hsa:23354; O94927; Q6P2P7; Q7L3D5; Q96CT8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.096" "0.967" "1.186" "1.076" "0.980" "1.080" "1.165" "0.984" "1.021" "278.3" "305.1" "269.3" "330.2" "299.4" "272.8" "300.6" "324.3" "274.0" "284.3" "" "" "" "" "" "" "" "" "" "" "278.3" "258.1" "170.3" "240.8" "245.3" "211.9" "231.7" "278.8" "213.9" "255.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.000" "False" "25.613" "72" "3" "7" "3" "76" "7.9" "4.25" "23.71" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "" "2" "0" "1.061" "0.833" "1.035" "0.998" "0.854" "1.133" "1.012" "0.957" "0.900" "143.2" "151.8" "119.2" "148.2" "143.0" "122.3" "162.2" "144.9" "137.0" "128.9" "" "" "" "" "" "" "" "" "" "" "143.2" "128.5" "75.4" "108.1" "117.1" "95.0" "125.1" "124.6" "107.0" "115.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "25.606" "19" "7" "11" "7" "353" "39.3" "7.88" "34.38" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "0.935" "1.037" "0.933" "0.928" "1.014" "0.986" "0.981" "0.967" "1.007" "747.7" "699.2" "775.1" "697.6" "694.0" "758.4" "737.3" "733.2" "722.9" "752.7" "" "" "" "" "" "" "" "" "" "" "747.7" "591.5" "490.1" "508.7" "568.6" "588.9" "568.4" "630.4" "564.3" "676.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "25.604" "10" "8" "10" "8" "843" "100.1" "6.32" "31.93" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.021" "1.080" "1.073" "1.046" "1.106" "1.059" "1.089" "1.006" "1.014" "530.3" "541.6" "572.7" "569.0" "554.5" "586.4" "561.8" "577.2" "533.3" "537.5" "" "" "" "" "" "" "" "" "" "" "530.3" "458.2" "362.1" "414.9" "454.3" "455.4" "433.1" "496.3" "416.3" "483.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "25.578" "10" "2" "4" "2" "264" "30.2" "7.50" "16.00" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "1.234" "0.905" "0.964" "1.252" "0.924" "1.101" "1.106" "0.941" "0.945" "167.9" "207.3" "151.9" "161.8" "210.3" "155.1" "184.8" "185.7" "158.0" "158.8" "" "" "" "" "" "" "" "" "" "" "167.9" "175.4" "96.1" "118.0" "172.3" "120.5" "142.5" "159.6" "123.3" "142.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7495090606117370342" "False" "High" "IsMasterProtein" "P08631" "Tyrosine-protein kinase HCK OS=Homo sapiens OX=9606 GN=HCK PE=1 SV=5" "0.000" "False" "25.570" "11" "6" "12" "4" "526" "59.6" "6.70" "29.55" "6" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3055" "ENSG00000101336" "HCK" "A8K1I1; B4DQB6; E1P5M2; hsa:3055; P08631; Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; Q9UMJ5" "Thymic stromal lymphopoietin (TSLP) signaling pathway; IL-3 signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Nef and signal transduction; FLT3 signaling through SRC family kinases" "15" "1" "1.043" "0.887" "1.014" "1.004" "0.927" "0.997" "1.007" "0.954" "0.981" "321.0" "334.8" "284.6" "325.4" "322.3" "297.4" "320.0" "323.1" "306.3" "314.8" "" "" "" "" "" "" "" "" "" "" "321.0" "283.2" "180.0" "237.3" "264.0" "231.0" "246.7" "277.8" "239.1" "283.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "25.564" "32" "3" "6" "3" "126" "13.9" "10.32" "19.54" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA processing" "mRNA Splicing - Major Pathway; snRNP Assembly; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.056" "1.144" "1.060" "1.098" "1.071" "1.083" "1.062" "1.084" "1.055" "214.9" "226.9" "245.9" "227.8" "236.0" "230.1" "232.8" "228.1" "232.9" "226.6" "" "" "" "" "" "" "" "" "" "" "214.9" "192.0" "155.5" "166.1" "193.3" "178.7" "179.4" "196.1" "181.8" "203.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "25.504" "14" "8" "9" "5" "538" "60.2" "5.01" "28.31" "8" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Ebola virus infection in host" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "10" "2" "1.098" "0.957" "1.115" "1.125" "0.954" "1.079" "0.997" "1.035" "1.070" "380.8" "418.3" "364.3" "424.6" "428.3" "363.3" "411.1" "379.7" "394.2" "407.4" "" "" "" "" "" "" "" "" "" "" "380.8" "353.9" "230.4" "309.6" "350.9" "282.2" "316.9" "326.5" "307.7" "366.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "25.464" "22" "5" "8" "5" "317" "36.9" "4.40" "29.29" "5" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "1.137" "0.800" "1.068" "1.151" "0.928" "1.287" "1.134" "0.945" "1.072" "213.9" "243.1" "171.2" "228.5" "246.2" "198.5" "275.4" "242.6" "202.2" "229.3" "" "" "" "" "" "" "" "" "" "" "213.9" "205.7" "108.2" "166.6" "201.7" "154.1" "212.3" "208.6" "157.8" "206.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8294412632701656103" "False" "High" "IsMasterProtein" "O60239" "SH3 domain-binding protein 5 OS=Homo sapiens OX=9606 GN=SH3BP5 PE=1 SV=2" "0.000" "False" "25.452" "13" "6" "9" "6" "455" "50.4" "4.97" "29.96" "6" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05276" "9467" "ENSG00000131370" "SH3BP5" "B3KQW6; hsa:9467; O60239; Q5JWV9" "" "" "0" "0" "0.910" "0.823" "1.062" "1.030" "0.899" "1.119" "0.992" "0.995" "0.936" "433.4" "394.5" "356.6" "460.1" "446.6" "389.8" "485.1" "430.0" "431.2" "405.5" "" "" "" "" "" "" "" "" "" "" "433.4" "333.8" "225.5" "335.5" "365.9" "302.7" "374.0" "369.7" "336.6" "364.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "25.451" "12" "5" "10" "5" "404" "44.8" "4.84" "33.39" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.986" "0.936" "0.951" "0.931" "0.997" "0.956" "0.994" "0.962" "0.998" "381.8" "376.6" "357.4" "363.1" "355.5" "380.7" "365.0" "379.3" "367.1" "380.9" "" "" "" "" "" "" "" "" "" "" "381.8" "318.6" "226.0" "264.7" "291.3" "295.6" "281.4" "326.1" "286.6" "342.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "25.394" "47" "8" "12" "8" "146" "16.4" "10.21" "36.71" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; SARS-CoV-1 modulates host translation machinery; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "19" "0" "0.965" "1.043" "0.937" "0.889" "1.095" "0.962" "1.062" "1.196" "1.050" "638.8" "616.2" "666.4" "598.6" "568.2" "699.5" "614.6" "678.2" "763.7" "670.8" "" "" "" "" "" "" "" "" "" "" "638.8" "521.3" "421.4" "436.4" "465.5" "543.2" "473.8" "583.1" "596.1" "603.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "25.383" "7" "5" "9" "5" "859" "97.1" "9.19" "26.25" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "MAPK6/MAPK4 signaling; M-decay: degradation of maternal mRNAs by maternally stored factors; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "24" "0" "1.067" "1.092" "1.073" "1.058" "1.178" "1.051" "1.062" "1.212" "1.091" "580.4" "619.2" "633.9" "622.8" "614.1" "683.6" "610.2" "616.1" "703.4" "633.1" "" "" "" "" "" "" "" "" "" "" "580.4" "523.9" "400.9" "454.1" "503.1" "530.8" "470.4" "529.7" "549.0" "569.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "High" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.000" "False" "25.332" "17" "8" "9" "8" "430" "48.0" "9.92" "27.79" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.969" "0.931" "0.951" "1.038" "0.915" "1.068" "1.050" "0.881" "1.006" "597.2" "578.8" "556.0" "568.1" "620.0" "546.2" "637.8" "627.2" "526.0" "600.5" "" "" "" "" "" "" "" "" "" "" "597.2" "489.7" "351.6" "414.2" "508.0" "424.2" "491.6" "539.3" "410.6" "539.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "25.318" "14" "3" "7" "3" "391" "42.1" "9.00" "26.39" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "RUNX1 regulates transcription of genes involved in BCR signaling" "4" "0" "1.003" "0.920" "1.087" "1.194" "0.980" "1.116" "1.091" "0.904" "1.037" "197.2" "197.8" "181.5" "214.4" "235.6" "193.4" "220.2" "215.1" "178.3" "204.5" "" "" "" "" "" "" "" "" "" "" "197.2" "167.4" "114.7" "156.3" "193.0" "150.2" "169.7" "185.0" "139.2" "183.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "25.315" "26" "4" "8" "4" "184" "20.9" "6.34" "26.04" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Joubert syndrome" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "4" "0" "1.055" "1.005" "0.983" "1.089" "1.055" "1.016" "0.946" "0.952" "1.055" "416.5" "439.5" "418.4" "409.3" "453.4" "439.3" "423.2" "393.9" "396.3" "439.3" "" "" "" "" "" "" "" "" "" "" "416.5" "371.8" "264.5" "298.4" "371.5" "341.1" "326.2" "338.6" "309.4" "394.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "25.298" "9" "6" "10" "4" "765" "86.1" "7.08" "32.82" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Sterol regulatory element-binding proteins (SREBP) signaling" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "1.157" "1.003" "1.159" "1.091" "1.212" "1.218" "1.127" "1.098" "1.030" "227.8" "263.5" "228.6" "264.0" "248.5" "276.2" "277.5" "256.7" "250.1" "234.6" "" "" "" "" "" "" "" "" "" "" "227.8" "223.0" "144.6" "192.5" "203.6" "214.5" "213.9" "220.7" "195.3" "210.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "25.297" "7" "4" "5" "4" "725" "80.4" "7.78" "19.67" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Amino acid metabolism" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "4" "0" "1.023" "1.150" "1.143" "1.082" "1.071" "1.049" "1.110" "1.112" "1.150" "288.0" "294.5" "331.0" "329.1" "311.6" "308.5" "302.1" "319.6" "320.2" "331.3" "" "" "" "" "" "" "" "" "" "" "288.0" "249.1" "209.3" "240.0" "255.3" "239.6" "232.9" "274.8" "249.9" "297.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "25.261" "13" "5" "9" "5" "403" "44.0" "7.23" "23.14" "5" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.122" "1.150" "1.212" "1.023" "1.144" "1.019" "1.047" "1.166" "1.099" "100.8" "113.1" "115.9" "122.2" "103.1" "115.3" "102.7" "105.5" "117.5" "110.8" "" "" "" "" "" "" "" "" "" "" "100.8" "95.7" "73.3" "89.1" "84.4" "89.5" "79.1" "90.7" "91.7" "99.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "25.199" "22" "7" "9" "7" "348" "38.3" "6.73" "28.88" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "Galactose catabolism; Defective GALE causes EDG" "4" "0" "1.067" "0.918" "1.078" "1.030" "0.900" "1.028" "1.066" "0.972" "1.016" "541.6" "577.8" "497.2" "584.0" "557.7" "487.6" "556.6" "577.4" "526.6" "550.1" "" "" "" "" "" "" "" "" "" "" "541.6" "488.8" "314.4" "425.8" "456.9" "378.7" "429.1" "496.4" "411.0" "494.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "25.167" "5" "6" "6" "5" "1720" "194.7" "7.03" "21.69" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.152" "1.201" "1.135" "1.140" "1.245" "1.209" "1.094" "0.960" "1.003" "78.0" "89.9" "93.8" "88.6" "88.9" "97.2" "94.4" "85.3" "74.9" "78.3" "" "" "" "" "" "" "" "" "" "" "78.0" "76.1" "59.3" "64.6" "72.9" "75.5" "72.7" "73.4" "58.5" "70.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "25.127" "7" "6" "7" "6" "887" "101.5" "6.81" "21.33" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "24" "0" "1.012" "0.929" "1.029" "0.944" "0.881" "1.035" "0.975" "0.920" "1.028" "416.6" "421.5" "387.1" "428.7" "393.1" "366.9" "431.0" "406.2" "383.3" "428.0" "" "" "" "" "" "" "" "" "" "" "416.6" "356.6" "244.8" "312.6" "322.1" "284.9" "332.2" "349.3" "299.2" "384.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "25.108" "17" "6" "11" "6" "366" "41.2" "5.02" "35.90" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "1.087" "1.199" "1.030" "1.034" "1.090" "1.036" "1.097" "1.169" "1.235" "289.4" "314.7" "347.0" "298.0" "299.3" "315.5" "299.7" "317.5" "338.3" "357.3" "" "" "" "" "" "" "" "" "" "" "289.4" "266.2" "219.4" "217.3" "245.2" "245.0" "231.0" "273.0" "264.1" "321.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "25.101" "18" "9" "10" "9" "518" "58.2" "8.13" "28.91" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Selenium metabolism and selenoproteins" "Mitochondrial tRNA aminoacylation" "2" "0" "1.121" "1.083" "1.002" "1.046" "1.052" "1.091" "1.051" "1.068" "1.036" "413.8" "463.9" "448.2" "414.6" "432.8" "435.4" "451.4" "435.0" "441.9" "428.6" "" "" "" "" "" "" "" "" "" "" "413.8" "392.5" "283.4" "302.3" "354.6" "338.1" "347.9" "374.0" "344.9" "385.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "25.095" "10" "3" "7" "3" "346" "39.2" "5.50" "31.20" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "15" "0" "1.126" "1.069" "1.246" "1.220" "1.074" "1.136" "1.044" "1.064" "1.111" "263.1" "296.3" "281.3" "327.8" "321.0" "282.4" "298.8" "274.7" "280.0" "292.2" "" "" "" "" "" "" "" "" "" "" "263.1" "250.6" "177.9" "239.1" "263.0" "219.3" "230.3" "236.2" "218.6" "262.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "25.081" "23" "4" "10" "4" "215" "24.9" "5.55" "41.99" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Condensation of Prometaphase Chromosomes; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "0.967" "1.012" "0.903" "1.016" "1.102" "0.994" "1.064" "0.982" "0.977" "847.1" "818.8" "857.2" "764.8" "860.8" "933.8" "841.8" "901.4" "831.5" "827.3" "" "" "" "" "" "" "" "" "" "" "847.1" "692.8" "542.0" "557.7" "705.2" "725.1" "648.9" "775.0" "649.0" "743.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "25.074" "23" "6" "8" "6" "229" "25.2" "4.64" "27.04" "6" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "11" "0" "0.997" "1.159" "1.070" "1.132" "1.286" "1.371" "1.019" "1.157" "1.093" "718.0" "715.7" "832.2" "768.1" "812.7" "923.6" "984.5" "732.0" "831.0" "784.5" "" "" "" "" "" "" "" "" "" "" "718.0" "605.5" "526.2" "560.1" "665.9" "717.3" "758.9" "629.4" "648.7" "705.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "25.072" "16" "5" "6" "5" "405" "44.5" "6.70" "20.54" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "12" "0" "1.100" "1.170" "1.088" "1.205" "1.194" "1.152" "1.189" "1.211" "1.150" "168.3" "185.1" "196.9" "183.1" "202.8" "201.0" "193.8" "200.2" "203.8" "193.5" "" "" "" "" "" "" "" "" "" "" "168.3" "156.6" "124.5" "133.5" "166.1" "156.1" "149.4" "172.1" "159.1" "173.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "25.063" "25" "4" "12" "4" "176" "18.4" "9.44" "34.25" "4" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "0.972" "1.021" "0.957" "0.956" "1.043" "1.080" "0.932" "0.953" "1.003" "547.0" "531.5" "558.5" "523.3" "523.1" "570.5" "590.7" "509.6" "521.5" "548.5" "" "" "" "" "" "" "" "" "" "" "547.0" "449.7" "353.2" "381.6" "428.6" "443.1" "455.3" "438.2" "407.1" "493.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "25.048" "15" "4" "7" "4" "329" "36.0" "7.02" "26.93" "4" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "1.042" "1.188" "1.074" "1.097" "1.132" "1.174" "1.097" "1.135" "1.126" "367.2" "382.5" "436.2" "394.3" "402.7" "415.5" "431.2" "403.0" "416.7" "413.5" "" "" "" "" "" "" "" "" "" "" "367.2" "323.6" "275.8" "287.5" "329.9" "322.7" "332.4" "346.5" "325.2" "371.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "25.034" "25" "4" "6" "3" "158" "18.7" "5.73" "22.92" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "0.936" "1.025" "1.041" "1.055" "1.064" "1.034" "1.046" "1.002" "1.065" "246.4" "230.6" "252.7" "256.5" "260.0" "262.2" "254.9" "257.8" "247.0" "262.5" "" "" "" "" "" "" "" "" "" "" "246.4" "195.1" "159.8" "187.0" "213.0" "203.6" "196.5" "221.7" "192.8" "236.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "25.011" "10" "5" "7" "5" "556" "63.1" "7.36" "22.89" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "46" "0" "0.905" "0.785" "1.064" "0.966" "0.827" "1.058" "1.011" "0.864" "0.904" "282.9" "256.2" "222.1" "301.0" "273.4" "234.1" "299.2" "286.0" "244.3" "255.8" "" "" "" "" "" "" "" "" "" "" "282.9" "216.7" "140.4" "219.4" "224.0" "181.8" "230.7" "245.9" "190.7" "230.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "25.007" "22" "6" "8" "6" "326" "36.1" "9.17" "23.05" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "HuR (ELAVL1) binds and stabilizes mRNA" "10" "0" "1.163" "1.393" "1.002" "1.088" "1.398" "1.086" "1.078" "1.440" "1.155" "457.2" "531.9" "636.9" "458.0" "497.5" "639.3" "496.4" "492.6" "658.2" "528.2" "" "" "" "" "" "" "" "" "" "" "457.2" "450.0" "402.7" "334.0" "407.6" "496.5" "382.6" "423.6" "513.8" "474.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "24.925" "36" "4" "8" "4" "125" "13.8" "6.07" "22.47" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "1.022" "0.999" "0.932" "0.979" "0.924" "0.939" "0.868" "0.903" "1.043" "751.7" "767.9" "751.2" "700.2" "736.2" "694.6" "705.8" "652.3" "679.0" "784.2" "" "" "" "" "" "" "" "" "" "" "751.7" "649.6" "475.0" "510.6" "603.2" "539.4" "544.1" "560.8" "530.0" "705.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "24.904" "23" "5" "8" "5" "224" "24.4" "7.50" "27.08" "5" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.004" "1.028" "1.095" "1.044" "1.039" "1.095" "1.010" "1.077" "1.032" "576.4" "578.4" "592.4" "631.2" "602.0" "599.0" "631.4" "582.3" "620.8" "594.9" "" "" "" "" "" "" "" "" "" "" "576.4" "489.4" "374.6" "460.3" "493.2" "465.2" "486.7" "500.7" "484.6" "534.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.000" "False" "24.897" "10" "6" "8" "6" "580" "65.7" "6.13" "24.79" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "18" "0" "1.054" "0.969" "1.042" "1.064" "0.975" "1.047" "1.013" "0.968" "1.027" "413.4" "435.6" "400.5" "430.8" "439.9" "403.3" "433.0" "418.9" "400.0" "424.7" "" "" "" "" "" "" "" "" "" "" "413.4" "368.5" "253.2" "314.1" "360.4" "313.2" "333.8" "360.2" "312.3" "381.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "24.880" "26" "4" "6" "4" "172" "18.8" "5.69" "23.68" "4" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "0.988" "1.073" "0.939" "0.989" "1.168" "1.138" "0.935" "0.985" "1.008" "434.0" "428.9" "465.5" "407.5" "429.1" "507.1" "493.9" "405.7" "427.5" "437.7" "" "" "" "" "" "" "" "" "" "" "434.0" "362.9" "294.3" "297.1" "351.5" "393.8" "380.7" "348.8" "333.7" "393.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "24.854" "6" "6" "8" "6" "916" "102.8" "4.91" "25.02" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.041" "0.905" "0.965" "1.013" "0.818" "0.885" "0.997" "0.905" "0.917" "352.2" "366.7" "318.9" "339.9" "356.8" "288.1" "311.6" "351.3" "318.9" "323.0" "" "" "" "" "" "" "" "" "" "" "352.2" "310.2" "201.6" "247.9" "292.3" "223.7" "240.2" "302.1" "248.9" "290.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "24.847" "8" "6" "8" "6" "773" "85.9" "6.28" "22.90" "6" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "1p36 copy number variation syndrome" "Vitamin B5 (pantothenate) metabolism" "2" "0" "0.998" "0.981" "1.037" "1.045" "1.024" "0.918" "1.164" "0.873" "0.994" "247.2" "246.6" "242.6" "256.3" "258.3" "253.1" "226.8" "287.7" "215.8" "245.6" "" "" "" "" "" "" "" "" "" "" "247.2" "208.6" "153.4" "186.9" "211.6" "196.6" "174.8" "247.4" "168.5" "220.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "24.820" "9" "8" "9" "8" "718" "83.0" "5.92" "29.73" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "0.924" "0.982" "1.062" "1.069" "1.006" "1.059" "0.999" "0.942" "0.880" "557.2" "514.7" "547.3" "591.5" "595.7" "560.3" "590.1" "556.7" "524.9" "490.5" "" "" "" "" "" "" "" "" "" "" "557.2" "435.5" "346.1" "431.3" "488.0" "435.1" "454.9" "478.6" "409.7" "441.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "24.819" "13" "3" "8" "2" "261" "29.3" "6.70" "27.71" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage" "3" "0" "1.034" "0.964" "1.034" "0.977" "0.959" "1.101" "1.015" "0.884" "0.967" "219.3" "226.7" "211.5" "226.9" "214.2" "210.4" "241.5" "222.7" "193.9" "212.1" "" "" "" "" "" "" "" "" "" "" "219.3" "191.8" "133.7" "165.4" "175.5" "163.4" "186.2" "191.5" "151.3" "190.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "24.743" "34" "4" "10" "4" "151" "16.3" "10.05" "40.51" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.027" "1.053" "1.047" "1.062" "1.174" "1.128" "1.076" "1.172" "1.111" "471.7" "484.6" "496.6" "493.6" "500.9" "553.6" "531.8" "507.3" "552.6" "524.2" "" "" "" "" "" "" "" "" "" "" "471.7" "410.0" "314.0" "359.9" "410.4" "429.9" "409.9" "436.2" "431.3" "471.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "24.730" "23" "4" "10" "4" "166" "18.2" "7.99" "27.64" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.047" "1.199" "1.117" "1.047" "1.213" "1.042" "1.025" "1.222" "1.005" "487.4" "510.4" "584.4" "544.4" "510.3" "591.4" "508.0" "499.7" "595.4" "490.0" "" "" "" "" "" "" "" "" "" "" "487.4" "431.9" "369.5" "396.9" "418.1" "459.3" "391.6" "429.6" "464.7" "440.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "24.674" "14" "4" "5" "4" "480" "52.6" "6.37" "17.36" "4" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "1.021" "0.885" "0.958" "1.070" "0.842" "0.985" "1.111" "0.948" "1.045" "163.1" "166.5" "144.3" "156.3" "174.6" "137.4" "160.6" "181.2" "154.6" "170.5" "" "" "" "" "" "" "" "" "" "" "163.1" "140.9" "91.2" "114.0" "143.0" "106.7" "123.8" "155.8" "120.7" "153.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "24.659" "19" "5" "9" "5" "264" "29.4" "6.98" "31.43" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "0.989" "0.966" "0.949" "0.985" "0.954" "0.987" "0.995" "0.957" "0.967" "1073.1" "1061.7" "1037.1" "1017.9" "1057.5" "1023.5" "1058.6" "1067.7" "1026.9" "1037.7" "" "" "" "" "" "" "" "" "" "" "1073.1" "898.2" "655.7" "742.2" "866.4" "794.8" "816.0" "918.0" "801.6" "932.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "24.657" "5" "5" "9" "5" "1059" "112.1" "7.30" "26.81" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.069" "0.963" "1.008" "1.052" "0.981" "1.107" "1.091" "1.059" "1.243" "195.8" "209.3" "188.5" "197.3" "206.0" "192.1" "216.7" "213.6" "207.4" "243.3" "" "" "" "" "" "" "" "" "" "" "195.8" "177.1" "119.2" "143.9" "168.8" "149.2" "167.1" "183.7" "161.9" "218.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "24.640" "17" "6" "10" "6" "412" "45.7" "6.48" "31.87" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "1" "0" "1.015" "0.809" "1.050" "0.995" "0.783" "1.036" "0.994" "0.779" "0.989" "509.6" "517.1" "412.4" "535.0" "506.8" "399.1" "527.8" "506.4" "397.0" "503.8" "" "" "" "" "" "" "" "" "" "" "509.6" "437.5" "260.8" "390.1" "415.3" "309.9" "406.8" "435.4" "309.9" "452.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "24.635" "16" "8" "9" "8" "548" "61.1" "7.36" "23.19" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine metabolism" "Pyrimidine salvage" "2" "0" "0.934" "0.893" "1.014" "1.029" "0.929" "0.995" "1.111" "0.862" "0.845" "148.2" "138.4" "132.3" "150.4" "152.5" "137.7" "147.5" "164.6" "127.8" "125.2" "" "" "" "" "" "" "" "" "" "" "148.2" "117.1" "83.7" "109.6" "124.9" "106.9" "113.7" "141.6" "99.7" "112.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "24.555" "10" "7" "8" "7" "702" "80.4" "6.32" "27.10" "7" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "4" "0" "0.920" "0.961" "1.102" "0.925" "1.011" "0.889" "0.916" "0.964" "0.949" "191.1" "175.8" "183.7" "210.6" "176.8" "193.3" "169.9" "175.1" "184.1" "181.3" "" "" "" "" "" "" "" "" "" "" "191.1" "148.7" "116.1" "153.6" "144.9" "150.1" "131.0" "150.5" "143.7" "163.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "24.544" "16" "7" "8" "7" "434" "50.1" "8.10" "25.46" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "2" "0" "1.072" "1.156" "1.038" "1.128" "1.000" "1.109" "1.183" "1.104" "0.989" "254.5" "272.8" "294.2" "264.1" "287.1" "254.5" "282.1" "301.0" "281.0" "251.7" "" "" "" "" "" "" "" "" "" "" "254.5" "230.8" "186.0" "192.6" "235.3" "197.6" "217.5" "258.8" "219.3" "226.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3294406842495901290" "False" "High" "IsMasterProtein" "Q8NHM5" "Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1" "0.000" "False" "24.515" "5" "6" "6" "6" "1336" "152.5" "8.56" "21.33" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf13621, Pf16866, Pf17811" "84678" "ENSG00000089094" "KDM2B" "A8MRS1; hsa:84678; Q1RLM7; Q8NCI2; Q8NHM5; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "HDMs demethylate histones" "2" "0" "0.972" "0.743" "0.940" "1.092" "0.777" "1.005" "1.065" "0.712" "0.926" "247.9" "240.9" "184.2" "233.1" "270.7" "192.5" "249.3" "264.1" "176.6" "229.7" "" "" "" "" "" "" "" "" "" "" "247.9" "203.8" "116.5" "169.9" "221.8" "149.5" "192.1" "227.1" "137.9" "206.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263352969811880337" "False" "High" "IsMasterProtein" "Q13432" "Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1" "0.000" "False" "24.502" "26" "5" "10" "4" "240" "26.9" "6.42" "33.20" "5" "cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05351" "9094" "ENSG00000109103" "UNC119" "A8K8G4; F1T095; hsa:9094; O95126; Q13432" "Joubert syndrome; Ciliopathies" "" "2" "1" "1.033" "0.822" "0.979" "1.043" "0.818" "0.946" "1.023" "0.908" "0.981" "580.1" "599.0" "476.9" "567.8" "604.8" "474.7" "548.7" "593.4" "526.5" "569.3" "" "" "" "" "" "" "" "" "" "" "580.1" "506.8" "301.6" "414.0" "495.5" "368.6" "423.0" "510.2" "410.9" "511.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "24.500" "16" "4" "7" "4" "301" "33.2" "8.82" "25.73" "4" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "" "NOSIP mediated eNOS trafficking" "1" "0" "0.992" "0.718" "0.921" "1.030" "0.803" "0.942" "1.040" "0.830" "0.947" "429.0" "425.8" "308.2" "394.9" "441.9" "344.6" "404.1" "446.1" "356.1" "406.1" "" "" "" "" "" "" "" "" "" "" "429.0" "360.2" "194.9" "288.0" "362.1" "267.6" "311.5" "383.5" "278.0" "365.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "24.495" "9" "3" "3" "3" "584" "61.4" "5.19" "12.09" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "IL-18 signaling pathway" "" "1" "0" "1.091" "0.852" "0.978" "1.094" "0.634" "1.065" "1.070" "0.589" "0.812" "43.4" "47.4" "37.0" "42.5" "47.5" "27.5" "46.2" "46.5" "25.6" "35.3" "" "" "" "" "" "" "" "" "" "" "43.4" "40.1" "23.4" "31.0" "38.9" "21.4" "35.6" "39.9" "20.0" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "24.480" "26" "6" "9" "6" "221" "25.5" "8.65" "29.93" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.051" "0.944" "0.983" "1.058" "1.136" "1.113" "1.126" "1.056" "1.116" "520.0" "546.5" "490.7" "511.2" "550.3" "590.9" "578.8" "585.3" "549.1" "580.5" "" "" "" "" "" "" "" "" "" "" "520.0" "462.3" "310.3" "372.7" "450.9" "458.9" "446.1" "503.2" "428.6" "521.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "24.479" "17" "5" "9" "5" "308" "33.8" "8.12" "27.23" "5" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.990" "1.022" "1.034" "1.096" "1.132" "1.056" "1.026" "1.128" "1.030" "447.8" "443.3" "457.4" "462.8" "490.7" "506.9" "472.9" "459.4" "505.2" "461.4" "" "" "" "" "" "" "" "" "" "" "447.8" "375.1" "289.2" "337.5" "402.0" "393.6" "364.5" "395.0" "394.3" "414.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "24.430" "16" "6" "10" "3" "381" "43.0" "5.71" "32.92" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "21" "0" "1.097" "1.055" "1.055" "1.137" "1.109" "0.990" "1.046" "1.015" "1.105" "182.4" "200.1" "192.4" "192.4" "207.4" "202.2" "180.5" "190.8" "185.2" "201.5" "" "" "" "" "" "" "" "" "" "" "182.4" "169.3" "121.7" "140.3" "169.9" "157.0" "139.1" "164.1" "144.5" "181.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "24.399" "6" "7" "9" "7" "1226" "136.0" "8.65" "24.97" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Measles virus infection; Cytosolic DNA-sensing pathway" "PKR-mediated signaling; Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "6" "0" "1.038" "0.920" "1.028" "1.037" "1.031" "0.932" "1.078" "1.082" "1.030" "483.6" "502.1" "444.9" "497.2" "501.6" "498.5" "450.9" "521.2" "523.5" "498.0" "" "" "" "" "" "" "" "" "" "" "483.6" "424.8" "281.3" "362.5" "411.0" "387.1" "347.6" "448.2" "408.6" "447.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "24.380" "11" "6" "7" "6" "621" "72.0" "8.70" "23.47" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.063" "0.983" "1.045" "1.125" "0.959" "1.172" "1.096" "0.991" "1.069" "577.7" "614.1" "567.7" "603.8" "649.8" "553.9" "677.0" "633.1" "572.3" "617.4" "" "" "" "" "" "" "" "" "" "" "577.7" "519.5" "358.9" "440.3" "532.4" "430.1" "521.8" "544.3" "446.7" "555.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "24.375" "30" "7" "13" "7" "240" "24.6" "11.19" "33.57" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.897" "0.915" "0.888" "0.978" "0.887" "0.971" "1.023" "0.943" "0.890" "241.7" "216.7" "221.0" "214.5" "236.3" "214.3" "234.6" "247.2" "227.9" "215.0" "" "" "" "" "" "" "" "" "" "" "241.7" "183.3" "139.7" "156.4" "193.6" "166.4" "180.9" "212.6" "177.9" "193.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "24.369" "12" "4" "7" "4" "375" "42.6" "8.56" "25.49" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "5" "0" "1.153" "1.152" "1.084" "1.157" "1.214" "1.027" "1.047" "1.086" "1.097" "431.4" "497.5" "497.1" "467.9" "499.3" "523.6" "442.9" "451.6" "468.5" "473.3" "" "" "" "" "" "" "" "" "" "" "431.4" "420.9" "314.3" "341.2" "409.1" "406.6" "341.4" "388.2" "365.7" "425.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "24.369" "29" "4" "11" "4" "154" "16.8" "5.24" "32.79" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "Hypusine synthesis from eIF5A-lysine" "3" "0" "0.931" "0.972" "0.950" "0.938" "0.913" "0.985" "0.955" "0.911" "0.921" "918.7" "854.8" "892.7" "872.9" "861.9" "838.3" "904.8" "877.5" "837.1" "846.5" "" "" "" "" "" "" "" "" "" "" "918.7" "723.2" "564.4" "636.4" "706.1" "651.0" "697.5" "754.4" "653.4" "761.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "24.352" "16" "7" "10" "7" "435" "49.6" "9.54" "30.88" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "Potential therapeutics for SARS; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "21" "0" "1.145" "1.231" "1.057" "1.080" "1.210" "0.996" "1.059" "1.163" "1.097" "371.2" "425.2" "456.9" "392.5" "401.0" "449.3" "369.7" "393.2" "431.6" "407.3" "" "" "" "" "" "" "" "" "" "" "371.2" "359.7" "288.9" "286.2" "328.6" "348.9" "285.0" "338.1" "336.9" "366.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "24.332" "37" "4" "6" "4" "165" "19.0" "5.21" "20.48" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "0.999" "0.975" "0.959" "1.110" "1.110" "1.141" "1.068" "1.004" "0.954" "170.0" "169.9" "165.8" "163.1" "188.8" "188.7" "194.1" "181.6" "170.8" "162.1" "" "" "" "" "" "" "" "" "" "" "170.0" "143.7" "104.8" "118.9" "154.7" "146.6" "149.6" "156.2" "133.3" "145.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "24.328" "13" "7" "8" "7" "633" "68.0" "9.94" "23.02" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.056" "0.907" "1.109" "1.147" "0.936" "1.145" "1.140" "0.883" "1.033" "292.0" "308.2" "264.9" "323.8" "335.0" "273.4" "334.3" "332.8" "258.0" "301.7" "" "" "" "" "" "" "" "" "" "" "292.0" "260.8" "167.5" "236.1" "274.4" "212.3" "257.7" "286.1" "201.4" "271.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "24.326" "10" "6" "7" "6" "691" "79.4" "5.67" "20.49" "6" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "" "TBC/RABGAPs" "1" "0" "1.008" "0.788" "0.940" "0.939" "0.654" "0.830" "0.870" "0.715" "0.876" "364.9" "367.8" "287.6" "343.1" "342.8" "238.8" "302.9" "317.4" "260.9" "319.6" "" "" "" "" "" "" "" "" "" "" "364.9" "311.1" "181.9" "250.2" "280.9" "185.4" "233.5" "272.9" "203.6" "287.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "24.315" "29" "3" "4" "3" "142" "16.0" "4.86" "16.63" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "0.937" "0.971" "1.008" "1.064" "0.977" "1.231" "1.114" "0.967" "0.992" "300.0" "281.1" "291.3" "302.4" "319.2" "293.3" "369.3" "334.3" "290.2" "297.7" "" "" "" "" "" "" "" "" "" "" "300.0" "237.8" "184.2" "220.5" "261.5" "227.7" "284.7" "287.4" "226.5" "267.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "24.310" "11" "6" "8" "5" "521" "55.9" "7.88" "26.10" "6" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "18" "1" "0.950" "1.057" "1.076" "1.046" "1.050" "1.032" "1.069" "0.980" "1.031" "246.5" "234.1" "260.6" "265.3" "257.9" "258.7" "254.4" "263.5" "241.7" "254.1" "" "" "" "" "" "" "" "" "" "" "246.5" "198.1" "164.8" "193.5" "211.3" "200.9" "196.1" "226.5" "188.7" "228.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "24.301" "8" "8" "8" "8" "1393" "152.7" "6.38" "20.88" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.114" "1.082" "1.381" "1.102" "1.178" "1.188" "1.094" "1.140" "1.051" "301.9" "336.5" "326.5" "417.1" "332.8" "355.8" "358.7" "330.3" "344.3" "317.4" "" "" "" "" "" "" "" "" "" "" "301.9" "284.7" "206.5" "304.1" "272.7" "276.3" "276.5" "284.0" "268.7" "285.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "24.289" "10" "5" "7" "5" "646" "71.6" "5.05" "21.47" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.098" "1.175" "1.073" "0.994" "1.051" "0.959" "1.046" "1.109" "0.985" "317.6" "348.6" "373.2" "340.9" "315.6" "333.8" "304.7" "332.1" "352.1" "312.9" "" "" "" "" "" "" "" "" "" "" "317.6" "294.9" "236.0" "248.6" "258.6" "259.2" "234.9" "285.5" "274.9" "281.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "24.278" "12" "4" "7" "4" "412" "45.5" "7.11" "22.92" "4" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.926" "0.934" "0.972" "0.945" "0.992" "1.002" "1.053" "0.996" "1.004" "491.9" "455.6" "459.7" "478.1" "465.1" "487.9" "492.8" "518.3" "489.9" "493.8" "" "" "" "" "" "" "" "" "" "" "491.9" "385.4" "290.7" "348.6" "381.0" "378.9" "379.9" "445.6" "382.4" "443.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "24.267" "15" "6" "7" "6" "377" "41.9" "9.16" "23.90" "6" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "1.005" "0.955" "0.972" "1.081" "0.989" "0.985" "1.067" "0.981" "0.975" "495.5" "497.9" "473.2" "481.4" "535.4" "490.0" "488.1" "528.6" "486.0" "483.2" "" "" "" "" "" "" "" "" "" "" "495.5" "421.3" "299.2" "351.0" "438.7" "380.5" "376.3" "454.5" "379.4" "434.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "24.201" "9" "3" "4" "3" "471" "51.9" "5.76" "16.92" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.099" "1.036" "1.186" "1.048" "1.083" "1.202" "1.054" "1.021" "1.231" "90.1" "99.0" "93.4" "106.8" "94.4" "97.6" "108.3" "95.0" "92.0" "110.9" "" "" "" "" "" "" "" "" "" "" "90.1" "83.8" "59.1" "77.9" "77.3" "75.8" "83.5" "81.7" "71.8" "99.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036187621347807091" "False" "High" "IsMasterProtein" "P23469" "Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1" "0.000" "False" "24.198" "11" "7" "9" "7" "700" "80.6" "7.02" "25.63" "7" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00102" "5791" "ENSG00000132334" "PTPRE" "hsa:5791; P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6" "" "" "0" "0" "1.076" "0.942" "1.113" "1.013" "1.040" "1.031" "1.067" "0.982" "1.129" "319.7" "344.2" "301.3" "356.0" "323.7" "332.6" "329.7" "341.0" "313.8" "361.0" "" "" "" "" "" "" "" "" "" "" "319.7" "291.2" "190.5" "259.5" "265.2" "258.3" "254.2" "293.2" "245.0" "324.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "24.182" "20" "3" "5" "3" "192" "20.7" "9.91" "16.75" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.056" "1.008" "0.912" "1.091" "0.973" "1.030" "0.957" "1.032" "0.967" "160.2" "169.2" "161.5" "146.2" "174.8" "155.8" "165.0" "153.2" "165.3" "154.9" "" "" "" "" "" "" "" "" "" "" "160.2" "143.1" "102.1" "106.6" "143.2" "121.0" "127.2" "131.8" "129.0" "139.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "24.160" "18" "6" "10" "4" "372" "42.8" "8.79" "31.76" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "20" "0" "0.720" "0.832" "0.749" "0.911" "0.635" "0.946" "0.790" "0.579" "0.897" "22.1" "15.9" "18.4" "16.6" "20.2" "14.1" "20.9" "17.5" "12.8" "19.9" "" "" "" "" "" "" "" "" "" "" "22.1" "13.5" "11.6" "12.1" "16.5" "10.9" "16.1" "15.0" "10.0" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.000" "False" "24.114" "22" "9" "10" "9" "390" "42.1" "4.81" "27.56" "9" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "0.959" "0.826" "1.032" "1.048" "0.877" "1.095" "1.058" "0.833" "1.017" "467.3" "448.1" "386.0" "482.0" "489.8" "409.6" "511.5" "494.4" "389.1" "475.3" "" "" "" "" "" "" "" "" "" "" "467.3" "379.1" "244.0" "351.5" "401.3" "318.1" "394.3" "425.1" "303.7" "427.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "24.114" "20" "5" "6" "5" "307" "34.5" "6.70" "23.43" "5" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "22q11.2 copy number variation syndrome" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "5" "0" "1.207" "1.090" "1.141" "1.048" "1.143" "1.110" "1.088" "1.218" "1.176" "323.6" "390.8" "352.8" "369.2" "339.1" "369.8" "359.3" "352.2" "394.1" "380.7" "" "" "" "" "" "" "" "" "" "" "323.6" "330.6" "223.1" "269.2" "277.8" "287.2" "277.0" "302.8" "307.6" "342.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489642059379383551" "False" "High" "IsMasterProtein" "Q6PD62" "RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1" "0.000" "False" "24.090" "7" "9" "13" "9" "1173" "133.4" "6.77" "36.61" "9" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13181, Pf13374" "9646" "ENSG00000198730" "CTR9" "D3DQV8; hsa:9646; Q15015; Q6PD62" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "5" "0" "0.991" "0.890" "1.022" "1.034" "0.898" "1.056" "1.035" "0.951" "1.036" "568.1" "562.9" "505.8" "580.6" "587.2" "510.2" "599.9" "587.9" "540.2" "588.8" "" "" "" "" "" "" "" "" "" "" "568.1" "476.3" "319.8" "423.3" "481.1" "396.2" "462.4" "505.5" "421.6" "529.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "24.090" "4" "4" "4" "4" "1410" "152.4" "8.60" "15.04" "4" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Ectoderm differentiation" "Signaling by ALK fusions and activated point mutants" "2" "0" "1.018" "0.918" "1.373" "1.241" "1.071" "1.542" "1.379" "1.164" "1.092" "16.7" "17.0" "15.3" "22.9" "20.7" "17.9" "25.7" "23.0" "19.4" "18.2" "" "" "" "" "" "" "" "" "" "" "16.7" "14.4" "9.7" "16.7" "17.0" "13.9" "19.8" "19.8" "15.1" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.000" "False" "24.073" "3" "5" "6" "5" "2071" "224.2" "7.17" "19.88" "5" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "1.073" "1.119" "1.107" "1.091" "1.030" "1.060" "1.147" "1.030" "1.128" "131.9" "141.5" "147.6" "146.0" "143.9" "135.8" "139.8" "151.2" "135.9" "148.8" "" "" "" "" "" "" "" "" "" "" "131.9" "119.7" "93.3" "106.4" "117.9" "105.5" "107.8" "130.0" "106.1" "133.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "24.058" "5" "6" "9" "6" "1026" "117.3" "5.55" "28.14" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "0.986" "0.809" "0.969" "1.035" "0.831" "1.001" "1.084" "0.804" "0.892" "477.8" "470.8" "386.7" "462.9" "494.3" "397.0" "478.2" "517.8" "384.3" "426.1" "" "" "" "" "" "" "" "" "" "" "477.8" "398.3" "244.5" "337.5" "405.0" "308.3" "368.6" "445.2" "300.0" "383.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "24.034" "10" "5" "7" "3" "483" "50.9" "8.75" "23.14" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "18" "1" "0.942" "0.849" "0.979" "0.958" "0.846" "1.002" "0.979" "0.910" "0.981" "596.6" "562.0" "506.6" "583.9" "571.3" "504.7" "597.5" "584.2" "542.9" "585.3" "" "" "" "" "" "" "" "" "" "" "596.6" "475.4" "320.3" "425.7" "468.1" "391.9" "460.6" "502.3" "423.7" "526.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6389747246599202641" "False" "High" "IsMasterProtein" "Q53SF7" "Cordon-bleu protein-like 1 OS=Homo sapiens OX=9606 GN=COBLL1 PE=1 SV=3" "0.000" "False" "24.027" "5" "5" "7" "5" "1128" "123.8" "6.58" "22.93" "5" "" "" "cytoskeletal activity" "Pf09469" "22837" "ENSG00000082438" "COBLL1" "A6NMZ3; hsa:22837; Q53SF7; Q6IQ33; Q7Z3I6; Q9BRH4; Q9UG88; Q9Y2I3" "" "" "0" "0" "0.910" "0.842" "0.944" "0.968" "0.984" "0.967" "0.882" "0.874" "0.956" "425.5" "387.2" "358.4" "401.5" "411.8" "418.8" "411.4" "375.3" "371.9" "406.7" "" "" "" "" "" "" "" "" "" "" "425.5" "327.5" "226.6" "292.8" "337.4" "325.2" "317.2" "322.7" "290.3" "365.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "24.014" "26" "5" "11" "2" "218" "24.4" "6.07" "32.61" "5" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; RAB geranylgeranylation; TBC/RABGAPs; MET receptor recycling" "9" "1" "1.115" "1.097" "1.294" "1.051" "1.181" "1.249" "1.160" "1.246" "1.192" "66.9" "74.6" "73.4" "86.6" "70.3" "79.0" "83.6" "77.6" "83.4" "79.8" "" "" "" "" "" "" "" "" "" "" "66.9" "63.1" "46.4" "63.1" "57.6" "61.4" "64.4" "66.7" "65.1" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "23.992" "40" "3" "14" "3" "83" "9.1" "8.50" "45.45" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.957" "1.269" "1.086" "1.078" "1.292" "1.107" "1.050" "1.310" "1.116" "885.6" "847.4" "1123.9" "961.6" "954.4" "1143.9" "980.5" "929.7" "1160.2" "988.2" "" "" "" "" "" "" "" "" "" "" "885.6" "716.9" "710.7" "701.1" "781.9" "888.3" "755.8" "799.3" "905.6" "888.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9128345059399950903" "False" "High" "IsMasterProtein" "P83436" "Conserved oligomeric Golgi complex subunit 7 OS=Homo sapiens OX=9606 GN=COG7 PE=1 SV=1" "0.000" "False" "23.911" "10" "8" "8" "8" "770" "86.3" "5.47" "23.63" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf10191" "91949" "ENSG00000168434" "COG7" "hsa:91949; P83436; Q6UWU7" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.963" "0.888" "1.104" "1.019" "0.916" "1.069" "1.041" "0.992" "1.050" "384.4" "370.3" "341.3" "424.5" "391.8" "352.2" "410.8" "400.2" "381.5" "403.6" "" "" "" "" "" "" "" "" "" "" "384.4" "313.3" "215.8" "309.5" "321.0" "273.5" "316.7" "344.1" "297.7" "362.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5446146544739154360" "False" "High" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "0.000" "False" "23.910" "14" "5" "6" "5" "476" "50.3" "7.37" "18.20" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "1.133" "0.937" "1.178" "1.208" "1.006" "1.206" "1.177" "1.105" "1.215" "154.9" "175.5" "145.1" "182.5" "187.2" "155.9" "186.9" "182.3" "171.2" "188.2" "" "" "" "" "" "" "" "" "" "" "154.9" "148.5" "91.8" "133.1" "153.4" "121.0" "144.1" "156.8" "133.6" "169.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "23.852" "14" "6" "8" "5" "507" "57.0" "6.83" "23.86" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "Ciliary landscape; Ciliopathies" "" "2" "0" "1.064" "1.007" "1.129" "1.087" "1.153" "1.182" "1.145" "1.089" "1.292" "82.8" "88.1" "83.4" "93.6" "90.0" "95.5" "97.9" "94.8" "90.2" "107.1" "" "" "" "" "" "" "" "" "" "" "82.8" "74.6" "52.7" "68.2" "73.8" "74.2" "75.5" "81.5" "70.4" "96.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "23.773" "33" "3" "6" "2" "112" "12.3" "9.09" "19.82" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "" "MASTL Facilitates Mitotic Progression" "1" "0" "0.806" "0.756" "0.924" "0.984" "0.805" "1.060" "0.869" "0.776" "0.911" "175.2" "141.3" "132.4" "161.9" "172.3" "140.9" "185.7" "152.3" "136.0" "159.5" "" "" "" "" "" "" "" "" "" "" "175.2" "119.5" "83.7" "118.0" "141.2" "109.5" "143.2" "130.9" "106.1" "143.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "23.768" "34" "3" "8" "3" "154" "16.0" "5.60" "39.32" "3" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.001" "1.058" "1.144" "1.045" "1.124" "1.231" "1.022" "1.078" "1.094" "498.3" "498.8" "527.1" "570.1" "520.8" "560.0" "613.6" "509.5" "537.3" "545.2" "" "" "" "" "" "" "" "" "" "" "498.3" "422.0" "333.3" "415.7" "426.7" "434.9" "473.0" "438.1" "419.4" "490.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "23.748" "10" "5" "8" "5" "490" "53.3" "5.43" "27.50" "5" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "" "Neutrophil degranulation" "1" "0" "1.019" "1.036" "1.103" "1.088" "1.120" "1.081" "1.009" "1.028" "1.101" "315.0" "320.9" "326.3" "347.4" "342.6" "352.8" "340.4" "317.7" "323.8" "346.7" "" "" "" "" "" "" "" "" "" "" "315.0" "271.5" "206.3" "253.3" "280.7" "274.0" "262.4" "273.1" "252.8" "311.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.000" "False" "23.728" "39" "2" "6" "2" "76" "8.5" "4.36" "21.34" "2" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "" "HSF1 activation; Attenuation phase" "3" "0" "0.994" "0.758" "1.026" "0.994" "0.927" "1.280" "0.996" "0.813" "0.961" "252.9" "251.5" "191.6" "259.5" "251.3" "234.5" "323.7" "251.8" "205.6" "242.9" "" "" "" "" "" "" "" "" "" "" "252.9" "212.8" "121.2" "189.2" "205.9" "182.1" "249.5" "216.5" "160.5" "218.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790868284272412731" "False" "High" "IsMasterProtein" "Q9UDY8" "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 OS=Homo sapiens OX=9606 GN=MALT1 PE=1 SV=1" "0.000" "False" "23.715" "10" "7" "8" "7" "824" "92.2" "5.73" "25.54" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656, Pf13895, Pf13927, Pf18703" "10892" "ENSG00000172175" "MALT1" "hsa:10892; Q9NTB7; Q9UDY8; Q9ULX4" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 22q11.2 copy number variation syndrome; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A/inflammasome pathway" "10" "0" "1.152" "0.881" "1.005" "1.068" "0.944" "1.052" "1.105" "0.901" "0.990" "315.4" "363.5" "277.8" "317.0" "336.8" "297.8" "331.8" "348.6" "284.3" "312.4" "" "" "" "" "" "" "" "" "" "" "315.4" "307.6" "175.7" "231.1" "275.9" "231.3" "255.8" "299.7" "221.9" "280.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "23.703" "17" "4" "5" "4" "278" "30.7" "5.49" "20.66" "4" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "" "Trafficking and processing of endosomal TLR" "1" "0" "1.049" "0.992" "0.960" "1.001" "1.041" "1.029" "0.980" "0.971" "0.964" "266.1" "279.1" "264.0" "255.5" "266.4" "277.0" "273.9" "260.8" "258.5" "256.6" "" "" "" "" "" "" "" "" "" "" "266.1" "236.1" "166.9" "186.3" "218.3" "215.1" "211.1" "224.2" "201.8" "230.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "23.656" "18" "8" "11" "8" "350" "39.6" "9.70" "31.58" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.008" "0.946" "1.032" "1.077" "0.986" "0.963" "1.044" "0.971" "0.997" "275.0" "277.3" "260.1" "283.7" "296.2" "271.3" "264.8" "287.1" "267.0" "274.1" "" "" "" "" "" "" "" "" "" "" "275.0" "234.6" "164.5" "206.9" "242.7" "210.7" "204.1" "246.8" "208.4" "246.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "23.649" "15" "7" "10" "7" "544" "61.5" "5.47" "28.96" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.089" "1.034" "1.055" "1.173" "1.051" "1.219" "1.115" "1.002" "1.040" "245.6" "267.5" "253.9" "259.2" "288.1" "258.2" "299.3" "273.9" "246.0" "255.4" "" "" "" "" "" "" "" "" "" "" "245.6" "226.3" "160.5" "189.0" "236.1" "200.5" "230.7" "235.5" "192.0" "229.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "23.642" "31" "4" "7" "4" "131" "15.5" "8.29" "25.48" "4" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.920" "1.114" "0.921" "0.968" "1.114" "1.177" "0.911" "1.034" "0.994" "742.9" "683.3" "827.7" "683.9" "719.3" "827.3" "874.6" "676.8" "767.9" "738.4" "" "" "" "" "" "" "" "" "" "" "742.9" "578.1" "523.3" "498.7" "589.3" "642.4" "674.2" "581.9" "599.4" "663.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "23.611" "16" "4" "8" "4" "303" "34.8" "5.87" "22.71" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Regulation of TNFR1 signaling; Downregulation of TGF-beta receptor signaling" "11" "0" "1.119" "1.108" "1.255" "1.117" "1.152" "1.085" "1.007" "1.156" "1.292" "87.1" "97.4" "96.5" "109.3" "97.3" "100.3" "94.5" "87.7" "100.7" "112.5" "" "" "" "" "" "" "" "" "" "" "87.1" "82.4" "61.0" "79.7" "79.7" "77.9" "72.9" "75.4" "78.6" "101.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.000" "False" "23.601" "16" "6" "9" "6" "421" "48.0" "7.68" "28.28" "6" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "0.951" "1.021" "0.980" "1.071" "0.956" "0.975" "1.045" "0.980" "0.909" "283.5" "269.6" "289.3" "277.8" "303.7" "270.9" "276.5" "296.3" "277.8" "257.7" "" "" "" "" "" "" "" "" "" "" "283.5" "228.1" "182.9" "202.6" "248.8" "210.4" "213.2" "254.7" "216.8" "231.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "23.597" "12" "6" "11" "6" "515" "56.1" "6.32" "27.63" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.071" "0.947" "1.061" "1.110" "1.013" "1.022" "1.049" "1.056" "1.060" "351.7" "376.5" "333.0" "373.3" "390.5" "356.3" "359.6" "369.0" "371.2" "372.6" "" "" "" "" "" "" "" "" "" "" "351.7" "318.5" "210.6" "272.2" "319.9" "276.7" "277.2" "317.3" "289.8" "335.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "23.576" "12" "6" "11" "6" "584" "61.6" "8.18" "31.04" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "1.177" "0.884" "1.074" "1.117" "0.875" "1.101" "1.120" "0.762" "0.924" "214.0" "251.8" "189.2" "229.9" "239.1" "187.2" "235.5" "239.7" "163.0" "197.9" "" "" "" "" "" "" "" "" "" "" "214.0" "213.1" "119.6" "167.6" "195.9" "145.4" "181.6" "206.1" "127.2" "177.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "23.569" "10" "5" "5" "5" "521" "59.4" "7.72" "17.96" "5" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "0.949" "0.864" "1.032" "1.082" "0.825" "0.877" "1.001" "0.860" "0.984" "298.0" "282.9" "257.4" "307.6" "322.3" "245.8" "261.4" "298.2" "256.3" "293.3" "" "" "" "" "" "" "" "" "" "" "298.0" "239.3" "162.7" "224.3" "264.1" "190.9" "201.5" "256.4" "200.0" "263.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "23.554" "20" "6" "8" "6" "337" "38.6" "6.38" "26.04" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.914" "0.974" "0.862" "0.973" "1.017" "0.909" "0.948" "0.967" "0.879" "385.3" "352.1" "375.1" "332.1" "374.9" "392.0" "350.1" "365.1" "372.7" "338.8" "" "" "" "" "" "" "" "" "" "" "385.3" "297.9" "237.2" "242.2" "307.1" "304.4" "269.9" "313.9" "290.9" "304.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "23.548" "11" "5" "9" "5" "485" "53.3" "7.34" "27.91" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "17q12 copy number variation syndrome" "" "1" "0" "0.936" "1.055" "0.976" "1.008" "1.056" "1.033" "0.986" "1.053" "1.126" "389.9" "365.1" "411.4" "380.6" "393.0" "411.7" "402.7" "384.3" "410.5" "439.2" "" "" "" "" "" "" "" "" "" "" "389.9" "308.9" "260.1" "277.5" "322.0" "319.7" "310.4" "330.4" "320.4" "394.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "23.545" "20" "6" "7" "6" "311" "33.2" "8.54" "24.34" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "6" "0" "0.958" "0.881" "0.957" "0.881" "0.902" "1.040" "1.007" "0.890" "0.963" "329.8" "315.8" "290.4" "315.7" "290.5" "297.6" "343.0" "332.1" "293.6" "317.6" "" "" "" "" "" "" "" "" "" "" "329.8" "267.2" "183.6" "230.2" "238.0" "231.1" "264.4" "285.5" "229.2" "285.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.000" "False" "23.538" "9" "7" "7" "7" "885" "100.8" "8.46" "19.03" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.990" "0.991" "0.953" "1.013" "0.998" "0.984" "1.011" "0.964" "1.037" "227.8" "225.6" "225.8" "217.0" "230.7" "227.2" "224.1" "230.3" "219.5" "236.2" "" "" "" "" "" "" "" "" "" "" "227.8" "190.8" "142.7" "158.2" "189.1" "176.5" "172.7" "198.0" "171.3" "212.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "23.500" "16" "6" "8" "6" "396" "45.8" "9.51" "27.22" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.026" "0.949" "0.941" "0.980" "0.919" "0.978" "1.031" "0.907" "0.990" "579.4" "594.3" "549.7" "545.4" "567.9" "532.3" "566.4" "597.6" "525.6" "573.8" "" "" "" "" "" "" "" "" "" "" "579.4" "502.8" "347.6" "397.7" "465.2" "413.4" "436.6" "513.8" "410.2" "515.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "23.486" "8" "4" "6" "4" "648" "71.9" "6.21" "18.97" "4" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "0.994" "1.038" "1.048" "1.018" "1.017" "1.028" "1.119" "0.989" "1.067" "291.7" "290.1" "302.7" "305.7" "296.9" "296.6" "299.8" "326.3" "288.4" "311.3" "" "" "" "" "" "" "" "" "" "" "291.7" "245.4" "191.4" "222.9" "243.3" "230.4" "231.1" "280.5" "225.1" "279.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "23.480" "12" "3" "7" "3" "386" "43.3" "6.01" "26.85" "3" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "0.946" "0.885" "1.021" "0.997" "0.914" "1.185" "1.075" "0.914" "0.816" "138.5" "131.1" "122.6" "141.5" "138.1" "126.6" "164.2" "149.0" "126.6" "113.0" "" "" "" "" "" "" "" "" "" "" "138.5" "110.9" "77.5" "103.1" "113.1" "98.3" "126.6" "128.1" "98.9" "101.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "23.457" "14" "5" "5" "5" "450" "50.8" "7.43" "16.31" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "1.263" "1.060" "1.256" "0.972" "0.974" "1.057" "1.042" "1.122" "1.125" "83.2" "105.1" "88.2" "104.6" "80.9" "81.1" "88.0" "86.7" "93.4" "93.6" "" "" "" "" "" "" "" "" "" "" "83.2" "88.9" "55.8" "76.2" "66.3" "63.0" "67.8" "74.5" "72.9" "84.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "23.435" "6" "6" "7" "6" "1043" "118.0" "5.80" "22.49" "6" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.177" "1.016" "1.001" "1.056" "1.054" "1.063" "1.097" "1.152" "1.095" "380.8" "448.2" "386.8" "381.2" "402.1" "401.3" "404.9" "417.8" "438.7" "417.0" "" "" "" "" "" "" "" "" "" "" "380.8" "379.2" "244.6" "277.9" "329.5" "311.6" "312.1" "359.2" "342.4" "374.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5653084663226725114" "False" "High" "IsMasterProtein" "Q96JJ3" "Engulfment and cell motility protein 2 OS=Homo sapiens OX=9606 GN=ELMO2 PE=1 SV=2" "0.000" "False" "23.434" "8" "7" "9" "2" "720" "82.6" "5.90" "28.13" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf04727, Pf11841, Pf16457" "63916" "ENSG00000062598" "ELMO2" "E1P5T3; hsa:63916; Q5JVZ6; Q7Z5G9; Q96CJ2; Q96JJ3; Q96ME5; Q96PA9; Q9H938; Q9H9L5; Q9HAH0; Q9NQQ6" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; RHOG GTPase cycle" "5" "0" "1.097" "0.899" "1.071" "1.102" "0.936" "1.044" "1.118" "0.957" "1.079" "198.7" "217.9" "178.7" "212.8" "219.1" "186.0" "207.5" "222.1" "190.1" "214.4" "" "" "" "" "" "" "" "" "" "" "198.7" "184.4" "113.0" "155.1" "179.5" "144.5" "160.0" "191.0" "148.4" "192.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "23.426" "7" "7" "9" "7" "898" "105.3" "7.30" "27.78" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "MAPK signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "4" "0" "0.985" "1.059" "1.055" "1.003" "0.941" "0.979" "1.063" "1.017" "1.023" "391.7" "385.9" "414.7" "413.1" "393.0" "368.5" "383.4" "416.3" "398.3" "400.9" "" "" "" "" "" "" "" "" "" "" "391.7" "326.5" "262.2" "301.2" "322.0" "286.2" "295.6" "358.0" "310.9" "360.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "23.422" "14" "4" "7" "4" "396" "42.4" "6.46" "27.10" "4" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.040" "0.908" "1.099" "1.016" "1.039" "1.151" "0.979" "0.959" "1.005" "189.5" "197.0" "172.0" "208.3" "192.4" "196.9" "218.0" "185.5" "181.8" "190.4" "" "" "" "" "" "" "" "" "" "" "189.5" "166.7" "108.8" "151.9" "157.7" "152.9" "168.0" "159.5" "141.9" "171.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "23.421" "11" "6" "8" "6" "498" "54.3" "5.53" "26.85" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.014" "0.909" "0.980" "0.949" "0.913" "0.986" "1.021" "0.937" "0.978" "551.8" "559.6" "501.5" "540.6" "523.8" "503.9" "544.1" "563.5" "517.2" "539.6" "" "" "" "" "" "" "" "" "" "" "551.8" "473.5" "317.1" "394.2" "429.2" "391.3" "419.4" "484.5" "403.7" "485.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "23.413" "9" "4" "5" "4" "473" "53.2" "8.29" "16.92" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "1.020" "0.867" "1.209" "1.020" "0.941" "1.041" "1.046" "0.769" "1.018" "211.3" "215.5" "183.3" "255.4" "215.6" "198.8" "220.0" "221.0" "162.5" "215.0" "" "" "" "" "" "" "" "" "" "" "211.3" "182.3" "115.9" "186.3" "176.6" "154.4" "169.6" "190.0" "126.9" "193.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "23.382" "14" "2" "5" "2" "195" "19.5" "4.67" "20.22" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "0.902" "1.015" "0.940" "0.904" "1.058" "1.100" "0.942" "0.944" "0.879" "280.2" "252.8" "284.3" "263.2" "253.3" "296.5" "308.3" "263.9" "264.4" "246.3" "" "" "" "" "" "" "" "" "" "" "280.2" "213.9" "179.8" "191.9" "207.5" "230.3" "237.6" "226.9" "206.4" "221.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "23.381" "13" "3" "7" "3" "252" "27.9" "9.73" "22.08" "3" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.000" "0.940" "1.002" "1.061" "0.957" "0.999" "1.051" "0.911" "0.975" "272.1" "272.0" "255.7" "272.5" "288.8" "260.3" "271.7" "286.0" "247.9" "265.2" "" "" "" "" "" "" "" "" "" "" "272.1" "230.1" "161.7" "198.7" "236.6" "202.2" "209.4" "245.9" "193.5" "238.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "23.379" "14" "3" "4" "3" "224" "25.2" "4.92" "15.14" "3" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "0.974" "0.993" "0.983" "1.017" "1.015" "1.072" "1.025" "1.012" "0.988" "392.1" "381.8" "389.4" "385.6" "398.6" "398.1" "420.4" "402.1" "396.9" "387.3" "" "" "" "" "" "" "" "" "" "" "392.1" "323.0" "246.2" "281.1" "326.6" "309.2" "324.1" "345.7" "309.8" "348.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "23.346" "25" "5" "7" "5" "207" "23.1" "6.93" "24.05" "5" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "1.059" "1.164" "1.026" "1.037" "1.120" "1.060" "0.993" "1.139" "1.101" "410.6" "434.6" "477.9" "421.4" "425.9" "460.0" "435.2" "407.8" "467.5" "452.2" "" "" "" "" "" "" "" "" "" "" "410.6" "367.7" "302.2" "307.2" "348.9" "357.2" "335.5" "350.6" "364.9" "406.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "23.340" "12" "5" "9" "5" "442" "49.7" "5.14" "33.13" "5" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "NF1 copy number variation syndrome" "" "1" "0" "0.962" "0.956" "0.994" "1.041" "0.958" "1.085" "1.090" "0.933" "1.002" "763.7" "735.1" "730.5" "759.1" "795.4" "731.8" "829.0" "832.6" "712.3" "765.5" "" "" "" "" "" "" "" "" "" "" "763.7" "621.9" "461.9" "553.5" "651.7" "568.3" "639.0" "715.9" "556.0" "688.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "23.329" "17" "2" "5" "2" "209" "23.2" "5.38" "23.27" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Ciliary landscape; 2q37 copy number variation syndrome" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.055" "1.179" "1.030" "1.107" "1.040" "0.981" "1.028" "1.098" "0.965" "237.8" "250.8" "280.4" "244.9" "263.3" "247.4" "233.2" "244.5" "261.0" "229.5" "" "" "" "" "" "" "" "" "" "" "237.8" "212.2" "177.3" "178.6" "215.7" "192.2" "179.8" "210.2" "203.8" "206.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "23.294" "5" "6" "6" "6" "1401" "151.6" "5.86" "21.20" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.995" "0.880" "1.022" "0.991" "0.876" "0.997" "0.972" "0.966" "0.967" "295.6" "294.2" "260.3" "302.2" "293.0" "259.0" "294.8" "287.5" "285.7" "285.9" "" "" "" "" "" "" "" "" "" "" "295.6" "248.9" "164.6" "220.3" "240.1" "201.1" "227.2" "247.2" "223.0" "257.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "23.293" "37" "5" "11" "5" "125" "13.7" "10.11" "33.13" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.004" "1.121" "0.986" "1.111" "1.293" "1.171" "1.163" "1.254" "1.123" "472.8" "474.6" "530.1" "466.2" "525.5" "611.3" "553.8" "549.8" "593.1" "531.0" "" "" "" "" "" "" "" "" "" "" "472.8" "401.6" "335.2" "339.9" "430.5" "474.7" "426.9" "472.7" "463.0" "477.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "23.288" "8" "3" "5" "3" "394" "44.4" "5.40" "17.03" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "2" "0" "1.049" "1.062" "1.104" "1.047" "1.021" "1.014" "1.052" "1.011" "0.975" "195.0" "204.6" "207.1" "215.4" "204.2" "199.0" "197.7" "205.2" "197.2" "190.1" "" "" "" "" "" "" "" "" "" "" "195.0" "173.1" "130.9" "157.0" "167.3" "154.6" "152.4" "176.4" "153.9" "170.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "23.287" "10" "4" "5" "4" "441" "50.2" "7.03" "17.16" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "15" "0" "0.998" "0.840" "0.844" "0.967" "0.987" "0.886" "1.011" "0.844" "0.948" "374.1" "373.4" "314.1" "315.8" "361.7" "369.3" "331.3" "378.1" "315.8" "354.5" "" "" "" "" "" "" "" "" "" "" "374.1" "315.9" "198.6" "230.3" "296.4" "286.8" "255.4" "325.1" "246.5" "318.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "23.274" "3" "9" "9" "8" "3013" "339.4" "5.58" "23.07" "9" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "1.129" "0.893" "1.189" "0.980" "0.906" "1.041" "1.055" "0.938" "1.044" "212.6" "239.9" "189.9" "252.9" "208.3" "192.6" "221.3" "224.3" "199.5" "221.9" "" "" "" "" "" "" "" "" "" "" "212.6" "203.0" "120.1" "184.4" "170.7" "149.6" "170.6" "192.8" "155.7" "199.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "23.268" "14" "4" "4" "4" "415" "46.7" "6.81" "18.88" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.968" "1.030" "1.089" "1.123" "1.087" "1.111" "1.030" "1.081" "1.077" "346.4" "335.4" "356.8" "377.2" "388.9" "376.6" "384.8" "356.9" "374.5" "373.1" "" "" "" "" "" "" "" "" "" "" "346.4" "283.7" "225.6" "275.0" "318.6" "292.4" "296.7" "306.8" "292.3" "335.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "23.255" "19" "3" "4" "3" "193" "21.7" "5.39" "17.27" "3" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.994" "1.086" "1.108" "1.079" "1.089" "1.099" "1.088" "1.013" "1.061" "212.5" "211.3" "230.8" "235.4" "229.4" "231.4" "233.6" "231.2" "215.3" "225.4" "" "" "" "" "" "" "" "" "" "" "212.5" "178.7" "145.9" "171.6" "187.9" "179.7" "180.1" "198.8" "168.1" "202.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "23.250" "9" "9" "10" "9" "889" "98.3" "6.68" "29.72" "9" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "Iron uptake and transport" "3" "0" "1.022" "1.018" "1.080" "0.979" "1.049" "1.017" "1.021" "1.008" "1.049" "515.7" "527.1" "524.7" "556.9" "504.9" "540.9" "524.4" "526.6" "519.7" "541.0" "" "" "" "" "" "" "" "" "" "" "515.7" "445.9" "331.8" "406.0" "413.7" "420.0" "404.2" "452.8" "405.6" "486.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "23.235" "21" "4" "8" "4" "182" "20.7" "8.69" "27.04" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Orexin receptor pathway" "Platelet degranulation" "2" "0" "0.958" "1.052" "0.890" "0.978" "1.039" "1.063" "0.955" "0.970" "1.013" "730.2" "699.7" "767.9" "650.1" "713.9" "758.6" "776.3" "697.5" "708.0" "739.5" "" "" "" "" "" "" "" "" "" "" "730.2" "591.9" "485.6" "474.1" "584.9" "589.1" "598.4" "599.7" "552.6" "664.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "879339039440763847" "False" "High" "IsMasterProtein" "A6NI72" "Putative neutrophil cytosol factor 1B OS=Homo sapiens OX=9606 GN=NCF1B PE=5 SV=2" "0.000" "False" "23.203" "12" "5" "7" "5" "391" "44.8" "9.13" "21.24" "5" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1B" "A6NI72" "" "" "0" "0" "1.064" "1.075" "0.975" "1.025" "1.048" "0.974" "1.047" "1.056" "1.144" "319.1" "339.4" "343.1" "311.2" "327.0" "334.5" "310.8" "334.1" "337.1" "365.2" "" "" "" "" "" "" "" "" "" "" "319.1" "287.1" "216.9" "226.9" "268.0" "259.7" "239.6" "287.3" "263.1" "328.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "23.202" "7" "3" "10" "3" "443" "48.2" "8.66" "31.71" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "Leptin signaling pathway; Primary ovarian insufficiency" "PTK6 Regulates Proteins Involved in RNA Processing" "3" "0" "1.093" "1.223" "0.905" "1.024" "1.121" "0.936" "0.953" "1.131" "0.895" "741.3" "810.3" "906.9" "670.8" "759.2" "830.8" "693.5" "706.5" "838.7" "663.2" "" "" "" "" "" "" "" "" "" "" "741.3" "685.5" "573.5" "489.1" "622.0" "645.2" "534.6" "607.5" "654.7" "596.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "23.199" "31" "5" "7" "4" "157" "18.6" "5.47" "23.53" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "" "Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.023" "0.897" "1.021" "0.960" "1.020" "1.117" "0.950" "1.014" "1.056" "216.0" "221.0" "193.9" "220.5" "207.4" "220.4" "241.4" "205.3" "219.1" "228.1" "" "" "" "" "" "" "" "" "" "" "216.0" "187.0" "122.6" "160.8" "169.9" "171.1" "186.0" "176.5" "171.0" "205.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "23.113" "12" "4" "6" "4" "321" "35.9" "6.60" "20.78" "4" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "" "GDP-fucose biosynthesis" "1" "0" "0.919" "0.907" "0.996" "0.971" "0.990" "1.029" "1.106" "0.932" "0.975" "122.1" "112.2" "110.7" "121.6" "118.6" "120.9" "125.6" "135.0" "113.7" "119.0" "" "" "" "" "" "" "" "" "" "" "122.1" "94.9" "70.0" "88.6" "97.2" "93.9" "96.8" "116.1" "88.8" "107.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "23.036" "27" "5" "11" "2" "213" "23.6" "6.06" "34.65" "5" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; RAB geranylgeranylation; MET receptor recycling" "4" "0" "1.034" "1.123" "1.224" "1.034" "1.316" "1.228" "0.998" "1.169" "1.209" "90.2" "93.3" "101.3" "110.4" "93.3" "118.7" "110.7" "90.0" "105.5" "109.0" "" "" "" "" "" "" "" "" "" "" "90.2" "78.9" "64.1" "80.5" "76.4" "92.2" "85.4" "77.4" "82.3" "98.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "23.025" "6" "7" "7" "6" "1302" "146.1" "6.55" "24.06" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "1.060" "0.931" "1.099" "1.063" "0.949" "0.990" "1.014" "0.950" "1.031" "346.3" "367.0" "322.3" "380.7" "368.0" "328.5" "342.9" "351.2" "329.0" "357.1" "" "" "" "" "" "" "" "" "" "" "346.3" "310.5" "203.8" "277.6" "301.5" "255.1" "264.4" "301.9" "256.8" "321.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "23.021" "11" "7" "8" "7" "613" "67.9" "5.40" "24.51" "7" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "TYROBP causal network in microglia" "" "1" "0" "1.066" "1.141" "1.034" "1.121" "1.159" "1.218" "1.136" "1.120" "1.030" "314.9" "335.6" "359.3" "325.5" "352.8" "365.0" "383.6" "357.7" "352.8" "324.3" "" "" "" "" "" "" "" "" "" "" "314.9" "283.9" "227.2" "237.4" "289.1" "283.4" "295.7" "307.6" "275.4" "291.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "22.974" "18" "3" "12" "3" "198" "21.3" "8.87" "34.41" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.940" "1.133" "0.917" "0.990" "1.070" "1.059" "0.929" "0.941" "0.992" "303.7" "285.5" "344.1" "278.4" "300.6" "325.0" "321.7" "282.1" "285.9" "301.4" "" "" "" "" "" "" "" "" "" "" "303.7" "241.6" "217.6" "203.0" "246.3" "252.4" "248.0" "242.5" "223.2" "271.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2837359330570591993" "False" "High" "IsMasterProtein" "Q15022" "Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3" "0.000" "False" "22.957" "8" "5" "6" "5" "739" "83.0" "8.81" "25.33" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf09733" "23512" "ENSG00000178691" "SUZ12" "hsa:23512; Q15022; Q96BD9" "Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; NF1 copy number variation syndrome" "HCMV Early Events; SUMOylation of chromatin organization proteins; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines" "15" "0" "1.067" "0.803" "0.995" "1.035" "0.820" "0.969" "1.048" "0.814" "0.959" "542.9" "579.3" "436.0" "540.4" "561.7" "445.2" "525.9" "568.8" "441.8" "520.8" "" "" "" "" "" "" "" "" "" "" "542.9" "490.1" "275.7" "394.0" "460.2" "345.7" "405.4" "489.1" "344.9" "468.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "22.952" "21" "3" "4" "3" "208" "22.5" "7.20" "16.41" "3" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "" "Peroxisomal protein import" "1" "0" "0.944" "0.980" "0.966" "1.001" "0.937" "1.070" "0.994" "0.869" "1.000" "182.5" "172.3" "178.9" "176.3" "182.7" "171.1" "195.3" "181.4" "158.6" "182.4" "" "" "" "" "" "" "" "" "" "" "182.5" "145.8" "113.1" "128.6" "149.7" "132.9" "150.6" "156.0" "123.8" "164.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "22.938" "28" "5" "13" "5" "152" "17.7" "10.99" "36.55" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.910" "1.177" "1.138" "1.051" "1.289" "1.200" "1.048" "1.303" "1.111" "619.8" "563.9" "729.6" "705.3" "651.7" "799.0" "743.6" "649.5" "808.0" "688.4" "" "" "" "" "" "" "" "" "" "" "619.8" "477.0" "461.3" "514.3" "533.9" "620.5" "573.2" "558.5" "630.7" "618.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "22.937" "20" "3" "8" "3" "190" "20.7" "9.54" "27.97" "3" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "0.990" "0.823" "0.951" "0.968" "0.933" "0.948" "0.923" "0.875" "0.995" "271.6" "268.9" "223.6" "258.3" "262.9" "253.3" "257.4" "250.8" "237.7" "270.3" "" "" "" "" "" "" "" "" "" "" "271.6" "227.5" "141.4" "188.3" "215.4" "196.7" "198.4" "215.6" "185.5" "243.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "22.935" "6" "5" "8" "3" "839" "94.5" "5.88" "22.53" "5" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.096" "0.913" "0.986" "0.973" "1.028" "1.043" "1.118" "1.008" "1.123" "211.6" "232.0" "193.2" "208.7" "205.8" "217.5" "220.6" "236.5" "213.4" "237.7" "" "" "" "" "" "" "" "" "" "" "211.6" "196.3" "122.2" "152.1" "168.6" "168.9" "170.0" "203.3" "166.6" "213.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "22.933" "9" "7" "7" "7" "699" "78.1" "8.29" "21.09" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Nanoparticle triggered autophagic cell death; Autophagy" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "6" "0" "0.989" "0.861" "1.027" "1.029" "0.979" "1.029" "1.021" "0.926" "1.006" "420.7" "416.2" "362.4" "432.2" "433.0" "411.9" "433.0" "429.6" "389.5" "423.2" "" "" "" "" "" "" "" "" "" "" "420.7" "352.1" "229.1" "315.2" "354.7" "319.8" "333.8" "369.4" "304.0" "380.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "22.897" "6" "4" "5" "4" "722" "79.2" "6.80" "19.31" "4" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialylation" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "3" "0" "1.096" "1.100" "1.106" "1.150" "1.217" "1.045" "1.137" "1.065" "1.182" "194.3" "212.9" "213.7" "214.9" "223.4" "236.5" "203.0" "220.8" "206.9" "229.6" "" "" "" "" "" "" "" "" "" "" "194.3" "180.1" "135.1" "156.7" "183.0" "183.7" "156.5" "189.9" "161.5" "206.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752521321789384052" "False" "High" "IsMasterProtein" "P00918" "Carbonic anhydrase 2 OS=Homo sapiens OX=9606 GN=CA2 PE=1 SV=2" "0.000" "False" "22.894" "15" "4" "5" "4" "260" "29.2" "7.40" "18.45" "4" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00194" "760" "ENSG00000104267" "CA2" "B2R7G8; hsa:760; P00918; Q6FI12; Q96ET9" "Proximal tubule transport" "Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide" "4" "0" "0.861" "0.981" "0.898" "0.949" "0.969" "0.918" "0.911" "1.030" "0.941" "460.9" "396.9" "452.2" "413.9" "437.3" "446.8" "422.9" "420.0" "474.5" "433.7" "" "" "" "" "" "" "" "" "" "" "460.9" "335.7" "285.9" "301.8" "358.3" "346.9" "326.0" "361.1" "370.4" "389.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2393292125676734128" "False" "High" "IsMasterProtein" "Q8IWY9" "Codanin-1 OS=Homo sapiens OX=9606 GN=CDAN1 PE=1 SV=4" "0.000" "False" "22.869" "7" "8" "9" "8" "1227" "134.0" "6.77" "28.52" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15296" "146059" "ENSG00000140326" "CDAN1" "hsa:146059; Q6NYD0; Q7Z7L5; Q8IWY9; Q969N3" "" "" "0" "0" "0.959" "0.924" "1.046" "1.089" "1.040" "0.982" "1.055" "1.096" "1.130" "195.8" "187.7" "180.9" "204.9" "213.3" "203.7" "192.4" "206.5" "214.7" "221.4" "" "" "" "" "" "" "" "" "" "" "195.8" "158.8" "114.4" "149.4" "174.8" "158.2" "148.3" "177.6" "167.6" "199.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124864541622501476" "False" "High" "IsMasterProtein" "P35711" "Transcription factor SOX-5 OS=Homo sapiens OX=9606 GN=SOX5 PE=1 SV=3" "0.000" "False" "22.836" "8" "6" "6" "6" "763" "84.0" "6.60" "20.15" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6660" "ENSG00000134532" "SOX5" "B7Z8V0; F5H5B0; hsa:6660; P35711; Q86UK8; Q8J017; Q8J018; Q8J019; Q8J020; Q8N1D9; Q8N7E0; Q8TEA4" "Neural crest differentiation; Male infertility; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "" "4" "0" "0.987" "0.927" "0.996" "1.012" "0.906" "1.064" "1.061" "0.907" "1.062" "360.7" "356.0" "334.4" "359.1" "364.8" "326.8" "383.7" "382.8" "327.2" "383.2" "" "" "" "" "" "" "" "" "" "" "360.7" "301.2" "211.4" "261.8" "298.9" "253.8" "295.8" "329.1" "255.4" "344.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "22.806" "23" "5" "10" "4" "286" "32.9" "5.85" "34.82" "5" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "7" "0" "1.040" "1.156" "1.231" "0.971" "1.053" "0.934" "0.885" "1.276" "1.108" "181.8" "189.0" "210.1" "223.8" "176.5" "191.4" "169.8" "160.8" "232.0" "201.3" "" "" "" "" "" "" "" "" "" "" "181.8" "159.9" "132.8" "163.2" "144.6" "148.6" "130.9" "138.3" "181.1" "181.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "22.733" "41" "5" "7" "5" "117" "13.7" "8.10" "25.55" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "TBC/RABGAPs; Macroautophagy" "5" "0" "0.900" "0.906" "1.065" "1.022" "0.892" "1.026" "1.060" "1.040" "0.958" "123.1" "110.7" "111.6" "131.1" "125.8" "109.8" "126.3" "130.4" "128.0" "117.9" "" "" "" "" "" "" "" "" "" "" "123.1" "93.7" "70.5" "95.6" "103.1" "85.3" "97.4" "112.2" "99.9" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4556564044268480545" "False" "High" "IsMasterProtein" "Q9NR19" "Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1" "0.000" "False" "22.725" "10" "8" "8" "8" "701" "78.5" "6.46" "27.49" "8" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00501, Pf13193, Pf16177" "55902" "ENSG00000131069" "ACSS2" "A6NE90; hsa:55902; Q5QPH2; Q5QPH3; Q8N238; Q96EL0; Q9NQP7; Q9NR19; Q9UJ15" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid" "Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation" "8" "0" "1.073" "0.945" "1.043" "1.032" "0.983" "0.965" "1.018" "0.976" "1.089" "689.1" "739.5" "651.5" "718.8" "711.0" "677.7" "664.9" "701.7" "672.9" "750.4" "" "" "" "" "" "" "" "" "" "" "689.1" "625.6" "411.9" "524.1" "582.6" "526.3" "512.5" "603.4" "525.3" "674.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8559290960834017297" "False" "High" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "0.000" "False" "22.719" "4" "4" "6" "4" "1311" "143.1" "5.73" "20.80" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "2" "0" "1.099" "1.049" "1.194" "1.179" "1.151" "1.080" "1.134" "0.944" "1.029" "117.9" "129.5" "123.6" "140.7" "139.0" "135.6" "127.3" "133.6" "111.2" "121.3" "" "" "" "" "" "" "" "" "" "" "117.9" "109.5" "78.2" "102.6" "113.9" "105.3" "98.1" "114.9" "86.8" "109.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "22.698" "8" "8" "8" "8" "1190" "132.9" "5.44" "17.32" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "0.941" "0.918" "0.875" "0.965" "0.872" "0.901" "0.988" "0.875" "0.875" "634.6" "597.5" "582.8" "555.5" "612.1" "553.1" "572.0" "627.0" "555.1" "555.3" "" "" "" "" "" "" "" "" "" "" "634.6" "505.5" "368.5" "405.0" "501.5" "429.5" "441.0" "539.1" "433.3" "499.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "22.675" "35" "4" "5" "3" "142" "16.8" "5.26" "17.06" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "" "Neutrophil degranulation" "1" "0" "1.128" "1.018" "1.064" "1.051" "1.046" "1.044" "1.090" "1.064" "1.051" "285.6" "322.1" "290.8" "303.9" "300.1" "298.6" "298.3" "311.3" "304.0" "300.2" "" "" "" "" "" "" "" "" "" "" "285.6" "272.5" "183.9" "221.6" "245.9" "231.9" "229.9" "267.7" "237.3" "269.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "22.655" "7" "5" "5" "4" "715" "80.7" "9.26" "19.16" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Effect of progerin on genes involved in progeria; TAR syndrome" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "8" "0" "1.036" "1.067" "1.006" "1.073" "1.038" "1.042" "1.101" "0.994" "1.064" "259.6" "269.0" "276.9" "261.2" "278.6" "269.4" "270.5" "285.8" "258.0" "276.3" "" "" "" "" "" "" "" "" "" "" "259.6" "227.5" "175.1" "190.4" "228.2" "209.2" "208.5" "245.7" "201.4" "248.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "22.634" "46" "3" "26" "3" "69" "7.8" "10.70" "63.49" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.079" "1.239" "1.134" "1.137" "1.271" "1.185" "1.135" "1.269" "1.108" "644.2" "694.9" "798.4" "730.5" "732.6" "819.0" "763.5" "731.0" "817.4" "713.8" "" "" "" "" "" "" "" "" "" "" "644.2" "587.9" "504.8" "532.6" "600.2" "636.0" "588.5" "628.5" "638.1" "641.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "22.630" "50" "3" "8" "3" "68" "7.4" "7.24" "28.68" "3" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Copper homeostasis" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "3" "0" "0.966" "0.990" "0.962" "0.959" "1.074" "1.213" "0.977" "1.034" "1.078" "592.3" "572.2" "586.4" "570.1" "567.8" "635.9" "718.6" "578.6" "612.5" "638.2" "" "" "" "" "" "" "" "" "" "" "592.3" "484.1" "370.8" "415.7" "465.2" "493.9" "553.9" "497.5" "478.1" "573.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "22.616" "4" "7" "7" "4" "1362" "152.1" "9.19" "23.42" "7" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "Potential therapeutics for SARS" "3" "0" "1.004" "0.952" "1.000" "1.022" "1.017" "1.007" "1.014" "0.994" "0.993" "487.2" "489.4" "463.8" "487.2" "498.1" "495.3" "490.7" "493.9" "484.2" "483.6" "" "" "" "" "" "" "" "" "" "" "487.2" "414.0" "293.2" "355.2" "408.1" "384.7" "378.3" "424.6" "377.9" "434.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "22.599" "13" "7" "8" "7" "593" "66.5" "8.09" "22.63" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Amino acid metabolism" "Mitochondrial tRNA aminoacylation" "2" "0" "1.037" "1.064" "0.941" "1.076" "1.067" "1.045" "0.979" "1.029" "1.079" "242.5" "251.6" "257.9" "228.1" "261.0" "258.7" "253.4" "237.3" "249.5" "261.6" "" "" "" "" "" "" "" "" "" "" "242.5" "212.8" "163.1" "166.3" "213.8" "200.9" "195.3" "204.1" "194.7" "235.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "22.577" "26" "5" "9" "5" "178" "18.9" "7.49" "28.41" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.873" "0.939" "0.962" "0.817" "0.867" "1.004" "0.923" "0.977" "0.940" "304.2" "265.5" "285.7" "292.6" "248.4" "263.6" "305.4" "280.7" "297.3" "285.9" "" "" "" "" "" "" "" "" "" "" "304.2" "224.6" "180.6" "213.4" "203.5" "204.7" "235.4" "241.3" "232.1" "257.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406429710445880592" "False" "High" "IsMasterProtein" "Q14511" "Enhancer of filamentation 1 OS=Homo sapiens OX=9606 GN=NEDD9 PE=1 SV=1" "0.000" "False" "22.567" "9" "6" "8" "6" "834" "92.8" "6.70" "20.90" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08824, Pf12026, Pf14604" "4739" "ENSG00000111859" "NEDD9" "A8K9G7; A8MSJ9; G5E9Y9; hsa:4739; Q14511; Q5T9R4; Q5XKI0" "TGF-beta signaling pathway; HDAC6 interactions in the central nervous system" "" "2" "0" "1.065" "1.028" "1.151" "1.156" "1.276" "1.254" "1.057" "1.060" "1.075" "109.0" "116.1" "112.0" "125.5" "126.0" "139.1" "136.7" "115.3" "115.5" "117.1" "" "" "" "" "" "" "" "" "" "" "109.0" "98.3" "70.8" "91.5" "103.2" "108.0" "105.4" "99.1" "90.2" "105.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "22.562" "29" "4" "7" "4" "148" "16.6" "11.00" "23.09" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.995" "1.324" "1.156" "1.034" "1.320" "1.110" "1.261" "1.362" "1.196" "190.6" "189.6" "252.3" "220.4" "197.1" "251.5" "211.5" "240.4" "259.5" "228.0" "" "" "" "" "" "" "" "" "" "" "190.6" "160.4" "159.5" "160.7" "161.5" "195.3" "163.1" "206.7" "202.6" "205.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "22.557" "29" "6" "17" "6" "180" "19.6" "6.02" "40.92" "6" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "3" "0" "1.031" "1.072" "1.060" "0.996" "1.073" "1.017" "0.975" "1.077" "1.083" "763.7" "787.3" "818.4" "809.7" "760.5" "819.7" "777.0" "744.9" "822.6" "827.2" "" "" "" "" "" "" "" "" "" "" "763.7" "666.1" "517.5" "590.4" "623.1" "636.6" "598.9" "640.5" "642.1" "743.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "22.549" "8" "4" "5" "4" "479" "55.4" "5.10" "17.60" "4" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "54" "0" "1.188" "0.835" "1.016" "1.069" "0.947" "0.959" "1.217" "0.878" "1.066" "92.5" "109.9" "77.3" "94.0" "98.9" "87.6" "88.7" "112.6" "81.3" "98.7" "" "" "" "" "" "" "" "" "" "" "92.5" "93.0" "48.9" "68.5" "81.0" "68.1" "68.4" "96.8" "63.4" "88.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.000" "False" "22.548" "11" "6" "6" "6" "523" "58.7" "8.76" "20.38" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.068" "0.968" "1.120" "1.114" "1.003" "1.008" "1.044" "1.045" "1.178" "383.1" "409.3" "370.8" "428.9" "426.7" "384.5" "386.1" "400.1" "400.6" "451.2" "" "" "" "" "" "" "" "" "" "" "383.1" "346.3" "234.5" "312.8" "349.6" "298.6" "297.6" "344.0" "312.7" "405.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1783792033634386114" "False" "High" "IsMasterProtein" "Q8N7H5" "RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2" "0.000" "False" "22.529" "12" "6" "6" "6" "531" "59.9" "4.63" "19.49" "6" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03985" "54623" "ENSG00000006712" "PAF1" "hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9" "Endoderm differentiation" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins" "5" "0" "0.960" "0.869" "0.923" "0.968" "0.915" "1.086" "0.988" "0.854" "0.980" "533.0" "511.8" "463.1" "492.0" "515.7" "487.6" "578.8" "526.4" "455.3" "522.3" "" "" "" "" "" "" "" "" "" "" "533.0" "433.0" "292.8" "358.8" "422.5" "378.7" "446.2" "452.6" "355.4" "469.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "22.514" "19" "6" "7" "6" "297" "33.6" "6.96" "23.99" "6" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "1.075" "1.385" "1.276" "1.148" "1.082" "1.158" "1.138" "1.252" "1.147" "28.3" "30.5" "39.2" "36.1" "32.5" "30.6" "32.8" "32.2" "35.5" "32.5" "" "" "" "" "" "" "" "" "" "" "28.3" "25.8" "24.8" "26.4" "26.7" "23.8" "25.3" "27.7" "27.7" "29.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "22.509" "24" "6" "10" "6" "244" "28.1" "6.65" "31.54" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "" "tRNA processing in the nucleus" "1" "0" "0.939" "0.946" "0.938" "0.946" "0.881" "0.989" "0.981" "0.919" "0.977" "866.0" "813.5" "819.0" "812.6" "819.3" "763.3" "856.4" "849.9" "795.7" "846.2" "" "" "" "" "" "" "" "" "" "" "866.0" "688.2" "517.9" "592.5" "671.2" "592.7" "660.1" "730.8" "621.1" "760.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "22.497" "17" "8" "12" "5" "437" "48.9" "7.80" "29.13" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Ebola virus infection in host; Ciliary landscape" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "6" "0" "0.776" "0.829" "0.945" "0.886" "0.763" "0.868" "0.884" "0.829" "0.910" "426.5" "331.1" "353.5" "402.9" "377.8" "325.5" "370.3" "376.9" "353.6" "387.9" "" "" "" "" "" "" "" "" "" "" "426.5" "280.1" "223.5" "293.8" "309.5" "252.8" "285.4" "324.0" "276.0" "348.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "High" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.000" "False" "22.488" "11" "3" "4" "3" "312" "34.2" "6.27" "16.13" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "20" "0" "1.021" "0.875" "1.101" "1.083" "0.868" "1.071" "1.079" "0.814" "1.002" "305.1" "311.3" "267.1" "335.9" "330.3" "264.7" "326.8" "329.2" "248.3" "305.6" "" "" "" "" "" "" "" "" "" "" "305.1" "263.4" "168.9" "245.0" "270.6" "205.5" "251.9" "283.1" "193.8" "274.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "22.488" "13" "7" "8" "7" "552" "60.4" "6.99" "25.27" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "53" "0" "0.945" "0.920" "0.980" "0.953" "0.928" "0.988" "0.991" "0.901" "0.974" "598.4" "565.4" "550.4" "586.2" "570.5" "555.2" "591.5" "593.3" "539.3" "582.6" "" "" "" "" "" "" "" "" "" "" "598.4" "478.3" "348.0" "427.4" "467.4" "431.1" "456.0" "510.1" "421.0" "523.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305466471512972771" "False" "High" "IsMasterProtein" "P0DMU9" "Cancer/testis antigen family 45 member A10 OS=Homo sapiens OX=9606 GN=CT45A10 PE=1 SV=1" "0.000" "False" "22.475" "27" "5" "8" "1" "189" "21.1" "9.55" "26.12" "5" "" "" "other molecular function" "Pf15300" "102723631" "ENSG00000269586" "CT45A10" "A8K842; B7ZMC5; hsa:102723631; P0DMU9; Q6NSH3" "" "" "0" "0" "1.109" "0.994" "0.949" "1.285" "0.964" "0.995" "0.986" "1.040" "1.074" "63.2" "70.1" "62.8" "60.0" "81.3" "61.0" "63.0" "62.4" "65.8" "67.9" "" "" "" "" "" "" "" "" "" "" "63.2" "59.3" "39.7" "43.7" "66.6" "47.3" "48.5" "53.6" "51.4" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8122184501551353547" "False" "High" "IsMasterProtein" "Q9NZI8" "Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2" "0.000" "False" "22.459" "11" "6" "7" "6" "577" "63.4" "9.20" "21.29" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10642" "ENSG00000159217" "IGF2BP1" "C9JT33; hsa:10642; Q9NZI8" "Brain-derived neurotrophic factor (BDNF) signaling pathway; eIF5A regulation in response to inhibition of the nuclear export system" "MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "4" "0" "1.157" "1.130" "1.010" "0.974" "0.895" "1.179" "0.916" "0.838" "1.049" "96.6" "111.8" "109.1" "97.6" "94.1" "86.4" "113.9" "88.5" "81.0" "101.4" "" "" "" "" "" "" "" "" "" "" "96.6" "94.6" "69.0" "71.1" "77.1" "67.1" "87.8" "76.1" "63.2" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "22.452" "5" "6" "7" "6" "1102" "123.5" "7.34" "22.12" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "1.077" "1.023" "1.051" "1.108" "1.166" "1.114" "1.037" "1.137" "1.105" "408.1" "439.6" "417.3" "428.9" "452.1" "475.9" "454.7" "423.0" "463.8" "450.8" "" "" "" "" "" "" "" "" "" "" "408.1" "371.9" "263.9" "312.7" "370.4" "369.6" "350.5" "363.7" "362.0" "405.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "22.439" "10" "6" "6" "6" "642" "72.3" "6.27" "21.72" "6" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "" "COPII-mediated vesicle transport; RHOA GTPase cycle" "2" "0" "1.015" "1.660" "0.993" "0.988" "1.606" "0.964" "0.948" "1.674" "1.225" "384.7" "390.4" "638.4" "382.0" "380.0" "617.9" "371.0" "364.6" "643.8" "471.1" "" "" "" "" "" "" "" "" "" "" "384.7" "330.3" "403.7" "278.5" "311.3" "479.9" "286.0" "313.5" "502.5" "423.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "22.399" "27" "2" "5" "2" "104" "12.3" "5.92" "17.67" "2" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.992" "1.263" "0.891" "0.906" "1.338" "1.098" "0.919" "1.320" "1.163" "328.7" "326.0" "415.2" "292.9" "297.9" "439.7" "360.8" "302.1" "433.8" "382.1" "" "" "" "" "" "" "" "" "" "" "328.7" "275.8" "262.5" "213.5" "244.1" "341.5" "278.1" "259.8" "338.6" "343.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "22.368" "19" "5" "8" "5" "292" "31.4" "6.32" "28.36" "5" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "1.086" "0.977" "1.021" "1.108" "1.021" "1.071" "1.096" "1.051" "0.974" "130.4" "141.6" "127.5" "133.1" "144.4" "133.1" "139.7" "143.0" "137.1" "127.0" "" "" "" "" "" "" "" "" "" "" "130.4" "119.8" "80.6" "97.0" "118.3" "103.4" "107.7" "122.9" "107.0" "114.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "22.347" "19" "7" "11" "7" "372" "42.4" "5.80" "31.80" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "1.101" "1.055" "1.124" "1.067" "1.051" "1.069" "1.120" "1.093" "1.082" "462.6" "509.3" "487.9" "520.0" "493.8" "486.0" "494.4" "518.0" "505.8" "500.4" "" "" "" "" "" "" "" "" "" "" "462.6" "430.9" "308.5" "379.2" "404.6" "377.4" "381.1" "445.4" "394.8" "449.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "22.282" "5" "5" "7" "5" "1314" "140.6" "5.03" "21.38" "5" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "17q12 copy number variation syndrome" "" "1" "0" "0.979" "0.888" "1.138" "1.023" "0.923" "1.027" "1.039" "0.876" "0.967" "354.0" "346.5" "314.3" "402.8" "362.3" "326.7" "363.6" "367.9" "310.3" "342.3" "" "" "" "" "" "" "" "" "" "" "354.0" "293.2" "198.8" "293.7" "296.8" "253.7" "280.3" "316.4" "242.2" "307.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "22.280" "5" "5" "6" "5" "1063" "118.4" "7.02" "20.42" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.043" "1.022" "1.095" "1.105" "1.013" "0.981" "1.032" "1.035" "1.025" "390.1" "406.7" "398.6" "427.0" "431.1" "395.1" "382.7" "402.6" "403.8" "399.9" "" "" "" "" "" "" "" "" "" "" "390.1" "344.1" "252.1" "311.4" "353.2" "306.9" "295.0" "346.1" "315.2" "359.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "22.266" "18" "5" "6" "5" "363" "38.9" "5.07" "19.52" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "" "POLB-Dependent Long Patch Base Excision Repair" "1" "0" "0.950" "1.003" "1.032" "0.972" "1.000" "1.030" "0.946" "1.014" "1.026" "237.9" "226.1" "238.6" "245.6" "231.3" "238.0" "245.1" "225.1" "241.2" "244.1" "" "" "" "" "" "" "" "" "" "" "237.9" "191.3" "150.9" "179.1" "189.5" "184.8" "188.9" "193.6" "188.3" "219.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.000" "False" "22.233" "26" "4" "5" "4" "178" "20.7" "9.16" "19.88" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.905" "1.040" "1.140" "1.083" "1.017" "1.091" "1.120" "1.110" "1.079" "127.2" "115.1" "132.3" "145.0" "137.8" "129.3" "138.7" "142.4" "141.1" "137.2" "" "" "" "" "" "" "" "" "" "" "127.2" "97.4" "83.6" "105.7" "112.9" "100.4" "106.9" "122.5" "110.1" "123.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "22.221" "10" "9" "10" "9" "646" "73.5" "7.15" "32.92" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.020" "1.122" "0.967" "1.024" "1.086" "0.986" "1.018" "1.116" "1.049" "801.7" "818.0" "899.7" "775.5" "821.3" "870.5" "790.1" "815.7" "894.7" "840.9" "" "" "" "" "" "" "" "" "" "" "801.7" "692.1" "568.9" "565.5" "672.9" "676.0" "609.1" "701.4" "698.3" "756.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "22.221" "25" "4" "8" "4" "157" "17.8" "11.25" "23.62" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.961" "1.144" "0.975" "0.898" "0.960" "0.892" "1.025" "1.216" "0.887" "270.8" "260.2" "309.7" "264.0" "243.1" "260.0" "241.5" "277.5" "329.4" "240.1" "" "" "" "" "" "" "" "" "" "" "270.8" "220.1" "195.8" "192.5" "199.2" "201.9" "186.2" "238.6" "257.1" "215.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "High" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.000" "False" "22.203" "9" "7" "8" "7" "725" "82.1" "5.33" "21.76" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "mTORC1-mediated signalling" "4" "0" "1.052" "0.667" "0.952" "1.049" "0.632" "0.969" "1.052" "0.611" "0.840" "98.0" "103.1" "65.4" "93.3" "102.8" "61.9" "95.0" "103.1" "59.9" "82.3" "" "" "" "" "" "" "" "" "" "" "98.0" "87.2" "41.3" "68.1" "84.2" "48.1" "73.2" "88.6" "46.7" "74.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "22.171" "11" "6" "6" "4" "514" "55.4" "6.90" "17.21" "6" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "4" "0" "0.979" "0.867" "1.066" "1.019" "0.828" "1.003" "0.963" "0.822" "0.928" "134.8" "132.0" "116.8" "143.7" "137.3" "111.6" "135.2" "129.7" "110.8" "125.0" "" "" "" "" "" "" "" "" "" "" "134.8" "111.7" "73.9" "104.8" "112.5" "86.7" "104.2" "111.5" "86.5" "112.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "22.157" "8" "4" "6" "4" "564" "62.2" "8.34" "22.21" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.117" "1.141" "1.019" "1.094" "1.172" "1.055" "0.977" "1.056" "1.167" "284.9" "318.3" "325.1" "290.2" "311.6" "334.0" "300.5" "278.3" "300.8" "332.5" "" "" "" "" "" "" "" "" "" "" "284.9" "269.3" "205.5" "211.6" "255.3" "259.4" "231.7" "239.3" "234.8" "299.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "22.135" "14" "7" "9" "7" "551" "60.2" "5.68" "29.47" "7" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "101" "0" "1.125" "0.972" "1.083" "1.119" "0.948" "1.173" "1.084" "0.932" "1.033" "326.9" "367.6" "317.6" "353.9" "365.7" "309.8" "383.4" "354.3" "304.8" "337.6" "" "" "" "" "" "" "" "" "" "" "326.9" "311.0" "200.8" "258.0" "299.6" "240.6" "295.5" "304.7" "237.9" "303.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "22.114" "11" "5" "5" "5" "559" "61.5" "7.50" "18.05" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "1.025" "0.988" "0.906" "1.032" "1.014" "0.909" "0.937" "1.056" "0.926" "165.2" "169.4" "163.2" "149.6" "170.4" "167.6" "150.2" "154.8" "174.4" "153.0" "" "" "" "" "" "" "" "" "" "" "165.2" "143.3" "103.2" "109.1" "139.6" "130.1" "115.8" "133.1" "136.2" "137.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-987846664266598251" "False" "High" "IsMasterProtein" "Q9NS87" "Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1" "0.000" "False" "22.100" "4" "6" "7" "6" "1388" "160.1" "6.00" "22.73" "6" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00225, Pf15908" "56992" "ENSG00000163808; ENSG00000280610" "KIF15" "hsa:56992; Q17RV9; Q69YL6; Q96JX7; Q9H280; Q9NS87" "Gastric cancer network 1" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "4" "0" "1.121" "0.734" "1.192" "1.121" "0.917" "1.116" "1.058" "0.947" "1.011" "117.0" "131.2" "85.9" "139.5" "131.2" "107.3" "130.6" "123.8" "110.9" "118.3" "" "" "" "" "" "" "" "" "" "" "117.0" "111.0" "54.3" "101.7" "107.5" "83.3" "100.7" "106.4" "86.5" "106.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "22.096" "9" "7" "7" "7" "889" "98.3" "5.59" "22.70" "7" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "" "CDC42 GTPase cycle; RAC1 GTPase cycle" "2" "0" "1.023" "1.072" "1.054" "1.099" "1.073" "1.084" "0.992" "1.127" "1.031" "365.7" "374.0" "391.9" "385.5" "401.8" "392.3" "396.5" "362.7" "412.2" "376.9" "" "" "" "" "" "" "" "" "" "" "365.7" "316.5" "247.8" "281.1" "329.2" "304.7" "305.6" "311.9" "321.7" "338.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108263305464485910" "False" "High" "IsMasterProtein" "O95644" "Nuclear factor of activated T-cells, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3" "0.000" "False" "22.088" "7" "6" "7" "4" "943" "101.2" "6.99" "18.26" "6" "stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4772" "ENSG00000131196" "NFATC1" "B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1; hsa:4772; O95644; Q12865; Q15793; Q2M1S3" "Heart development; RANKL/RANK signaling pathway; Ectoderm differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Wnt signaling; Vitamin D in inflammatory diseases; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; Th17 cell differentiation pathway; DYRK1A involvement regarding cell proliferation in brain development; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; IL-26 signaling pathways; T-cell receptor signaling pathway" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "20" "0" "1.039" "0.973" "1.040" "1.122" "0.971" "1.157" "1.195" "1.032" "1.007" "126.4" "131.3" "123.0" "131.5" "141.8" "122.7" "146.3" "151.1" "130.4" "127.2" "" "" "" "" "" "" "" "" "" "" "126.4" "111.1" "77.8" "95.9" "116.2" "95.3" "112.8" "129.9" "101.8" "114.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "22.056" "15" "2" "16" "2" "86" "9.7" "4.67" "47.20" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.218" "1.113" "1.162" "1.080" "1.146" "1.124" "1.057" "1.039" "1.012" "570.1" "694.1" "634.3" "662.6" "615.6" "653.4" "640.8" "602.4" "592.3" "577.1" "" "" "" "" "" "" "" "" "" "" "570.1" "587.2" "401.1" "483.2" "504.4" "507.4" "494.0" "517.9" "462.3" "518.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "22.056" "16" "7" "7" "7" "536" "61.5" "9.52" "21.95" "7" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "16" "0" "0.977" "1.312" "1.051" "0.954" "1.386" "0.975" "0.997" "1.221" "1.055" "273.2" "266.9" "358.5" "287.3" "260.8" "378.7" "266.4" "272.5" "333.6" "288.3" "" "" "" "" "" "" "" "" "" "" "273.2" "225.8" "226.7" "209.5" "213.6" "294.1" "205.4" "234.3" "260.4" "259.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.000" "False" "22.033" "9" "6" "6" "6" "745" "85.5" "6.29" "21.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.099" "0.930" "1.177" "1.121" "0.910" "1.005" "1.084" "0.884" "1.093" "309.3" "339.8" "287.7" "364.1" "346.6" "281.3" "310.7" "335.3" "273.5" "338.2" "" "" "" "" "" "" "" "" "" "" "309.3" "287.5" "181.9" "265.5" "284.0" "218.5" "239.5" "288.3" "213.5" "304.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "22.004" "5" "5" "6" "5" "941" "107.2" "6.46" "22.46" "5" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "1.008" "0.967" "1.002" "1.077" "0.935" "0.996" "1.045" "0.992" "1.057" "604.4" "608.9" "584.6" "605.8" "651.0" "565.3" "602.2" "631.6" "599.4" "638.6" "" "" "" "" "" "" "" "" "" "" "604.4" "515.2" "369.6" "441.7" "533.4" "439.0" "464.2" "543.1" "467.9" "574.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "21.992" "14" "4" "7" "3" "272" "31.2" "11.59" "21.86" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.974" "1.074" "0.873" "1.078" "1.149" "1.111" "1.069" "1.087" "1.107" "345.7" "336.7" "371.3" "302.0" "372.5" "397.3" "384.0" "369.6" "375.9" "382.7" "" "" "" "" "" "" "" "" "" "" "345.7" "284.8" "234.8" "220.2" "305.2" "308.5" "296.0" "317.8" "293.4" "344.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8890451219668255439" "False" "High" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "0.000" "False" "21.990" "8" "7" "8" "7" "954" "105.9" "9.06" "21.10" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.046" "0.923" "1.185" "1.065" "0.768" "1.040" "1.063" "0.864" "1.033" "65.9" "69.0" "60.8" "78.1" "70.2" "50.6" "68.6" "70.0" "56.9" "68.1" "" "" "" "" "" "" "" "" "" "" "65.9" "58.3" "38.5" "57.0" "57.5" "39.3" "52.9" "60.2" "44.4" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "21.990" "4" "7" "12" "5" "1490" "164.1" "9.44" "28.68" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "17q12 copy number variation syndrome" "TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.102" "1.020" "1.050" "1.171" "1.103" "1.229" "1.207" "1.063" "1.035" "256.7" "282.9" "261.9" "269.4" "300.5" "283.1" "315.4" "309.8" "272.9" "265.6" "" "" "" "" "" "" "" "" "" "" "256.7" "239.3" "165.6" "196.4" "246.2" "219.8" "243.1" "266.4" "213.0" "238.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.000" "False" "21.962" "13" "5" "7" "5" "396" "45.3" "8.69" "22.36" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "Ciliary landscape" "" "1" "0" "0.908" "0.873" "0.942" "0.956" "0.889" "0.950" "0.907" "0.889" "0.941" "760.2" "690.6" "663.5" "716.4" "726.7" "675.6" "722.2" "689.8" "675.9" "715.3" "" "" "" "" "" "" "" "" "" "" "760.2" "584.2" "419.5" "522.4" "595.4" "524.7" "556.7" "593.1" "527.6" "643.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "21.951" "10" "4" "4" "4" "545" "61.3" "7.17" "14.84" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "1.041" "1.099" "1.047" "0.993" "1.042" "0.851" "1.037" "1.095" "0.950" "88.0" "91.6" "96.7" "92.1" "87.4" "91.7" "74.9" "91.2" "96.4" "83.6" "" "" "" "" "" "" "" "" "" "" "88.0" "77.5" "61.1" "67.2" "71.6" "71.2" "57.7" "78.4" "75.2" "75.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "21.944" "18" "6" "6" "6" "309" "35.8" "6.09" "19.50" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "38" "0" "1.040" "1.028" "1.096" "1.042" "1.033" "1.092" "1.140" "0.994" "1.039" "254.5" "264.7" "261.5" "279.0" "265.1" "263.0" "277.9" "290.0" "252.9" "264.3" "" "" "" "" "" "" "" "" "" "" "254.5" "223.9" "165.3" "203.4" "217.2" "204.2" "214.2" "249.3" "197.4" "237.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "21.937" "8" "3" "5" "3" "513" "57.5" "7.18" "20.74" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.065" "1.195" "1.080" "0.903" "1.073" "1.029" "0.969" "1.109" "1.168" "151.7" "161.6" "181.2" "163.8" "136.9" "162.8" "156.1" "147.0" "168.3" "177.2" "" "" "" "" "" "" "" "" "" "" "151.7" "136.7" "114.6" "119.4" "112.2" "126.4" "120.3" "126.4" "131.4" "159.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.000" "False" "21.881" "9" "7" "7" "7" "848" "100.4" "8.00" "18.44" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.068" "0.772" "1.012" "0.995" "0.910" "1.089" "1.058" "0.954" "0.981" "165.9" "177.3" "128.1" "167.9" "165.1" "151.0" "180.7" "175.6" "158.3" "162.8" "" "" "" "" "" "" "" "" "" "" "165.9" "150.0" "81.0" "122.4" "135.2" "117.2" "139.3" "151.0" "123.6" "146.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "21.847" "22" "3" "10" "3" "136" "14.6" "10.04" "34.53" "3" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "0.932" "1.057" "0.913" "0.947" "1.026" "0.988" "0.938" "0.979" "1.027" "775.1" "722.4" "819.0" "707.5" "733.9" "795.4" "765.8" "726.9" "758.9" "796.1" "" "" "" "" "" "" "" "" "" "" "775.1" "611.2" "517.9" "515.8" "601.3" "617.7" "590.3" "625.0" "592.4" "715.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "21.844" "9" "4" "5" "4" "479" "52.6" "5.05" "18.74" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "MAPK signaling pathway" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "1.095" "0.863" "1.061" "0.961" "0.899" "0.943" "0.937" "0.932" "1.196" "52.1" "57.1" "45.0" "55.3" "50.1" "46.9" "49.1" "48.8" "48.6" "62.3" "" "" "" "" "" "" "" "" "" "" "52.1" "48.3" "28.4" "40.3" "41.0" "36.4" "37.9" "42.0" "37.9" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "21.842" "17" "5" "8" "5" "400" "43.4" "5.10" "32.26" "5" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "2" "0" "1.089" "1.125" "1.032" "1.044" "1.393" "1.261" "1.219" "1.205" "1.434" "99.1" "107.9" "111.5" "102.2" "103.5" "138.1" "125.0" "120.8" "119.5" "142.1" "" "" "" "" "" "" "" "" "" "" "99.1" "91.3" "70.5" "74.5" "84.8" "107.2" "96.3" "103.9" "93.3" "127.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "21.814" "17" "4" "5" "4" "351" "38.5" "7.37" "16.77" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.993" "0.973" "0.981" "1.058" "0.957" "0.988" "1.060" "0.966" "1.060" "138.5" "137.6" "134.8" "135.9" "146.5" "132.6" "136.8" "146.8" "133.8" "146.8" "" "" "" "" "" "" "" "" "" "" "138.5" "116.4" "85.2" "99.1" "120.1" "103.0" "105.5" "126.2" "104.4" "132.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "High" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.000" "False" "21.813" "4" "4" "4" "4" "1083" "123.8" "6.71" "14.61" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.033" "0.897" "1.051" "0.961" "0.987" "0.988" "0.985" "0.872" "1.095" "389.7" "402.6" "349.7" "409.7" "374.7" "384.8" "385.1" "384.0" "339.8" "426.8" "" "" "" "" "" "" "" "" "" "" "389.7" "340.6" "221.1" "298.8" "307.0" "298.8" "296.8" "330.1" "265.3" "383.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "21.779" "23" "5" "7" "5" "253" "28.1" "9.54" "26.64" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "2" "0" "1.044" "0.996" "1.059" "1.040" "1.039" "0.977" "0.999" "1.126" "1.083" "429.5" "448.2" "427.7" "455.0" "446.8" "446.4" "419.8" "428.9" "483.6" "465.3" "" "" "" "" "" "" "" "" "" "" "429.5" "379.2" "270.5" "331.8" "366.1" "346.6" "323.6" "368.8" "377.5" "418.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "21.778" "11" "5" "6" "5" "454" "51.3" "4.97" "20.31" "5" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "Transcriptional activation of mitochondrial biogenesis" "7" "0" "0.969" "0.897" "0.971" "0.942" "0.803" "0.944" "1.011" "0.870" "1.027" "310.3" "300.6" "278.3" "301.2" "292.2" "249.0" "293.0" "313.6" "270.0" "318.7" "" "" "" "" "" "" "" "" "" "" "310.3" "254.4" "176.0" "219.6" "239.4" "193.4" "225.9" "269.6" "210.7" "286.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "21.778" "15" "6" "11" "5" "314" "34.3" "8.85" "33.71" "6" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "12" "1" "1.105" "1.087" "0.963" "1.022" "1.088" "0.996" "0.969" "1.087" "1.005" "1151.3" "1272.0" "1252.0" "1109.0" "1176.5" "1253.0" "1146.7" "1115.5" "1251.8" "1156.8" "" "" "" "" "" "" "" "" "" "" "1151.3" "1076.1" "791.7" "808.6" "963.9" "973.1" "883.9" "959.1" "977.1" "1040.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "21.703" "9" "6" "7" "6" "622" "71.6" "7.31" "24.49" "6" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "1.192" "1.089" "1.180" "1.131" "1.071" "1.119" "1.097" "1.165" "1.037" "324.0" "386.4" "352.9" "382.4" "366.4" "346.9" "362.5" "355.4" "377.4" "336.1" "" "" "" "" "" "" "" "" "" "" "324.0" "326.9" "223.2" "278.8" "300.2" "269.4" "279.4" "305.5" "294.5" "302.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "21.688" "7" "6" "6" "6" "852" "92.8" "6.52" "20.06" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "14" "0" "1.065" "1.067" "1.074" "1.031" "0.981" "0.973" "1.089" "0.998" "1.050" "314.9" "335.3" "335.9" "338.3" "324.8" "309.1" "306.4" "343.1" "314.2" "330.6" "" "" "" "" "" "" "" "" "" "" "314.9" "283.7" "212.4" "246.7" "266.1" "240.0" "236.2" "295.0" "245.2" "297.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "21.675" "19" "6" "12" "6" "350" "39.4" "5.53" "32.34" "6" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "10" "0" "1.107" "1.152" "1.359" "1.119" "1.170" "1.144" "1.117" "1.044" "1.115" "250.3" "277.1" "288.4" "340.1" "280.2" "292.8" "286.4" "279.6" "261.3" "279.1" "" "" "" "" "" "" "" "" "" "" "250.3" "234.4" "182.4" "247.9" "229.5" "227.4" "220.8" "240.4" "204.0" "251.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-466153880284673871" "False" "High" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "0.000" "False" "21.633" "3" "6" "7" "2" "2000" "226.5" "7.30" "21.03" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "Effect of progerin on genes involved in progeria" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation" "8" "0" "1.078" "0.862" "1.016" "1.378" "1.122" "1.220" "1.197" "0.859" "1.040" "70.3" "75.8" "60.6" "71.5" "97.0" "79.0" "85.9" "84.2" "60.4" "73.2" "" "" "" "" "" "" "" "" "" "" "70.3" "64.2" "38.3" "52.1" "79.5" "61.3" "66.2" "72.4" "47.1" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4487628495145980375" "False" "High" "IsMasterProtein" "Q13425" "Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1" "0.000" "False" "21.612" "12" "6" "6" "6" "540" "57.9" "8.82" "16.94" "6" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6645" "ENSG00000168807" "SNTB2" "hsa:6645; Q13425; Q9BY09" "" "" "0" "0" "1.055" "0.937" "1.110" "1.046" "1.020" "1.121" "1.060" "0.968" "0.987" "307.9" "324.7" "288.5" "341.7" "322.1" "314.1" "345.2" "326.5" "298.0" "303.9" "" "" "" "" "" "" "" "" "" "" "307.9" "274.7" "182.4" "249.1" "263.9" "244.0" "266.1" "280.7" "232.6" "273.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7115142250704838097" "False" "High" "IsMasterProtein" "P08670" "Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4" "0.000" "False" "21.602" "15" "8" "8" "7" "466" "53.6" "5.12" "21.17" "8" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf04732" "7431" "ENSG00000026025" "VIM" "B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3" "Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins" "21" "0" "1.002" "1.229" "1.103" "1.051" "1.346" "1.131" "1.059" "1.138" "1.174" "178.0" "178.4" "218.8" "196.4" "187.0" "239.6" "201.4" "188.4" "202.5" "209.0" "" "" "" "" "" "" "" "" "" "" "178.0" "150.9" "138.4" "143.2" "153.2" "186.0" "155.2" "162.0" "158.1" "187.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "21.599" "19" "6" "9" "6" "312" "33.6" "5.62" "28.06" "6" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.000" "1.025" "1.045" "1.009" "0.985" "0.978" "0.981" "0.930" "0.991" "568.9" "568.6" "582.9" "594.4" "574.1" "560.2" "556.6" "558.0" "529.3" "563.6" "" "" "" "" "" "" "" "" "" "" "568.9" "481.1" "368.6" "433.4" "470.4" "435.1" "429.1" "479.8" "413.1" "506.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "21.581" "39" "3" "9" "3" "95" "10.8" "6.52" "34.32" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.883" "0.952" "0.962" "1.080" "0.943" "0.907" "0.903" "1.013" "1.059" "133.7" "118.1" "127.3" "128.6" "144.4" "126.1" "121.3" "120.7" "135.5" "141.6" "" "" "" "" "" "" "" "" "" "" "133.7" "99.9" "80.5" "93.8" "118.3" "98.0" "93.5" "103.8" "105.8" "127.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6364343737777032179" "False" "High" "IsMasterProtein" "P08754" "Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3" "0.000" "False" "21.567" "17" "5" "6" "2" "354" "40.5" "5.69" "17.46" "5" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2773" "ENSG00000065135" "GNAI3" "hsa:2773; P08754; P17539; Q5TZX1" "Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "18" "1" "1.016" "0.872" "1.141" "0.968" "0.939" "1.084" "1.134" "0.968" "0.997" "176.9" "179.7" "154.2" "201.8" "171.2" "166.1" "191.8" "200.7" "171.2" "176.3" "" "" "" "" "" "" "" "" "" "" "176.9" "152.0" "97.5" "147.1" "140.2" "129.0" "147.9" "172.5" "133.7" "158.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "21.553" "16" "3" "5" "3" "181" "21.2" "7.49" "19.97" "3" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events" "4" "0" "1.115" "0.913" "1.159" "1.119" "1.070" "1.226" "1.132" "0.963" "1.072" "241.8" "269.6" "220.6" "280.3" "270.5" "258.7" "296.5" "273.8" "232.9" "259.2" "" "" "" "" "" "" "" "" "" "" "241.8" "228.1" "139.5" "204.4" "221.6" "200.9" "228.5" "235.4" "181.8" "233.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "21.534" "6" "6" "6" "6" "1011" "113.7" "7.28" "20.01" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "1.064" "1.047" "0.977" "0.963" "1.001" "0.894" "0.931" "1.165" "1.073" "414.5" "440.9" "433.8" "405.1" "399.2" "415.1" "370.3" "386.0" "482.9" "444.6" "" "" "" "" "" "" "" "" "" "" "414.5" "373.0" "274.3" "295.4" "327.1" "322.3" "285.5" "331.9" "377.0" "399.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "21.527" "18" "8" "10" "8" "440" "47.5" "6.77" "30.42" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex; SUMOylation of transcription cofactors; Repression of WNT target genes; Signaling by TCF7L2 mutants" "14" "0" "1.060" "0.997" "1.005" "1.038" "0.964" "0.981" "1.017" "0.997" "1.023" "579.0" "613.5" "577.2" "581.9" "601.1" "558.0" "567.8" "588.8" "577.5" "592.5" "" "" "" "" "" "" "" "" "" "" "579.0" "519.1" "365.0" "424.3" "492.5" "433.3" "437.7" "506.3" "450.8" "532.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "21.524" "12" "6" "12" "4" "482" "55.1" "5.48" "36.33" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Potential therapeutics for SARS; Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "56" "2" "1.047" "1.029" "0.917" "1.017" "1.044" "0.963" "0.995" "1.010" "0.948" "550.5" "576.3" "566.4" "504.8" "559.9" "574.8" "530.1" "547.5" "556.1" "522.0" "" "" "" "" "" "" "" "" "" "" "550.5" "487.6" "358.1" "368.1" "458.7" "446.4" "408.6" "470.8" "434.0" "469.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "21.523" "6" "5" "6" "4" "930" "103.5" "5.97" "17.23" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "1" "1.014" "1.110" "1.035" "0.984" "1.098" "0.977" "0.904" "1.267" "1.072" "226.6" "229.9" "251.5" "234.5" "223.0" "248.9" "221.5" "204.9" "287.1" "243.0" "" "" "" "" "" "" "" "" "" "" "226.6" "194.5" "159.0" "171.0" "182.7" "193.3" "170.7" "176.1" "224.1" "218.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "21.480" "16" "4" "5" "4" "279" "30.5" "5.07" "22.31" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "0.960" "0.942" "0.996" "0.963" "0.933" "0.998" "0.963" "1.007" "0.909" "513.0" "492.5" "483.3" "510.9" "493.8" "478.7" "512.1" "494.0" "516.4" "466.5" "" "" "" "" "" "" "" "" "" "" "513.0" "416.6" "305.6" "372.5" "404.6" "371.8" "394.8" "424.7" "403.1" "419.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "21.421" "7" "6" "6" "6" "1034" "117.1" "7.87" "20.14" "6" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "1.010" "1.297" "0.985" "1.006" "1.291" "1.136" "1.045" "1.262" "1.059" "303.0" "306.0" "393.0" "298.4" "304.7" "391.3" "344.2" "316.6" "382.2" "320.9" "" "" "" "" "" "" "" "" "" "" "303.0" "258.9" "248.5" "217.6" "249.6" "303.9" "265.3" "272.2" "298.4" "288.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "21.415" "16" "6" "9" "5" "373" "41.7" "6.70" "28.85" "6" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "1" "1.057" "1.019" "1.008" "1.126" "1.026" "1.203" "1.106" "0.947" "0.976" "513.9" "543.0" "523.5" "518.1" "578.7" "527.2" "618.4" "568.2" "486.7" "501.5" "" "" "" "" "" "" "" "" "" "" "513.9" "459.4" "331.0" "377.8" "474.1" "409.4" "476.6" "488.5" "379.9" "450.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "21.411" "40" "5" "10" "5" "157" "16.6" "6.79" "30.12" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "1.019" "1.036" "1.036" "1.014" "1.062" "1.071" "0.953" "0.971" "0.990" "191.2" "194.8" "198.1" "198.0" "193.9" "203.0" "204.7" "182.1" "185.7" "189.2" "" "" "" "" "" "" "" "" "" "" "191.2" "164.8" "125.3" "144.4" "158.9" "157.6" "157.8" "156.6" "145.0" "170.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051974243482830997" "False" "High" "IsMasterProtein" "P21127" "Cyclin-dependent kinase 11B OS=Homo sapiens OX=9606 GN=CDK11B PE=1 SV=4" "0.000" "False" "21.405" "9" "8" "9" "8" "795" "92.6" "5.54" "21.69" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "984" "ENSG00000248333" "CDK11B" "B7ZVY7; hsa:984; J3KTL7; J3QR29; J3QR44; O95265; P21127; Q12817; Q12818; Q12819; Q12820; Q12822; Q8N530; Q9NZS5; Q9UBJ0; Q9UBQ1; Q9UBR0; Q9UNY2; Q9UP57; Q9UP58; Q9UP59" "1p36 copy number variation syndrome" "Recruitment of mitotic centrosome proteins and complexes" "2" "0" "1.175" "0.622" "0.946" "1.047" "1.102" "1.007" "1.050" "0.845" "1.157" "55.1" "64.7" "34.3" "52.1" "57.7" "60.7" "55.5" "57.8" "46.6" "63.8" "" "" "" "" "" "" "" "" "" "" "55.1" "54.8" "21.7" "38.0" "47.3" "47.2" "42.8" "49.7" "36.4" "57.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "21.390" "8" "3" "4" "3" "445" "46.7" "5.83" "12.46" "3" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "0.956" "1.289" "1.058" "0.945" "1.091" "1.090" "1.052" "1.094" "1.076" "180.6" "172.6" "232.8" "191.1" "170.6" "197.0" "197.0" "190.1" "197.6" "194.3" "" "" "" "" "" "" "" "" "" "" "180.6" "146.1" "147.2" "139.3" "139.8" "153.0" "151.8" "163.4" "154.2" "174.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "21.372" "27" "2" "11" "2" "113" "12.7" "7.44" "49.28" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "" "2" "0" "0.924" "0.855" "0.908" "0.986" "0.951" "1.038" "0.976" "0.888" "0.903" "620.3" "573.0" "530.5" "563.2" "611.8" "589.9" "643.6" "605.7" "551.1" "560.2" "" "" "" "" "" "" "" "" "" "" "620.3" "484.7" "335.5" "410.6" "501.2" "458.1" "496.1" "520.8" "430.1" "503.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "21.349" "4" "7" "7" "7" "1749" "195.9" "6.73" "22.73" "7" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "" "Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.980" "0.798" "1.110" "0.874" "0.730" "1.021" "1.078" "0.766" "0.895" "213.8" "209.4" "170.7" "237.3" "186.9" "156.0" "218.3" "230.4" "163.8" "191.3" "" "" "" "" "" "" "" "" "" "" "213.8" "177.2" "107.9" "173.0" "153.1" "121.2" "168.3" "198.1" "127.8" "172.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "High" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.000" "False" "21.344" "29" "3" "4" "3" "128" "15.1" "11.41" "16.67" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.079" "1.085" "1.221" "1.391" "1.053" "1.077" "1.311" "1.175" "1.235" "44.1" "47.5" "47.8" "53.8" "61.3" "46.4" "47.5" "57.8" "51.8" "54.5" "" "" "" "" "" "" "" "" "" "" "44.1" "40.2" "30.3" "39.3" "50.2" "36.0" "36.6" "49.7" "40.4" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "High" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.000" "False" "21.328" "5" "6" "7" "6" "1116" "128.0" "5.97" "16.61" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "Cell lineage map for neuronal differentiation" "" "1" "0" "0.935" "0.978" "1.059" "1.056" "1.010" "1.015" "0.992" "1.008" "0.995" "241.1" "225.3" "235.7" "255.2" "254.5" "243.4" "244.8" "239.2" "242.9" "239.9" "" "" "" "" "" "" "" "" "" "" "241.1" "190.6" "149.0" "186.1" "208.5" "189.0" "188.7" "205.7" "189.6" "215.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "21.292" "16" "5" "7" "5" "342" "38.9" "5.52" "23.95" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "1.019" "0.922" "1.098" "1.045" "0.969" "0.994" "1.065" "0.925" "0.955" "373.1" "380.4" "343.8" "409.8" "389.7" "361.4" "371.0" "397.4" "345.3" "356.4" "" "" "" "" "" "" "" "" "" "" "373.1" "321.8" "217.4" "298.8" "319.3" "280.6" "286.0" "341.7" "269.5" "320.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "21.279" "48" "4" "8" "4" "105" "11.7" "9.57" "25.16" "4" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "36" "0" "0.857" "0.979" "0.928" "0.837" "1.118" "0.902" "0.885" "1.096" "0.975" "72.5" "62.1" "71.0" "67.3" "60.6" "81.0" "65.4" "64.2" "79.4" "70.6" "" "" "" "" "" "" "" "" "" "" "72.5" "52.5" "44.9" "49.0" "49.7" "62.9" "50.4" "55.2" "62.0" "63.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "21.274" "11" "4" "7" "4" "367" "40.8" "6.14" "23.81" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.972" "1.049" "1.106" "1.026" "1.092" "1.011" "1.067" "1.194" "1.131" "190.7" "185.5" "200.0" "210.9" "195.7" "208.2" "192.8" "203.5" "227.7" "215.7" "" "" "" "" "" "" "" "" "" "" "190.7" "156.9" "126.4" "153.8" "160.3" "161.7" "148.6" "175.0" "177.7" "193.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.000" "False" "21.270" "12" "6" "8" "6" "475" "54.1" "6.38" "24.68" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "" "Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "5" "0" "1.075" "1.001" "1.078" "0.938" "0.890" "0.987" "0.985" "1.040" "1.028" "266.5" "286.5" "266.7" "287.3" "249.9" "237.1" "263.1" "262.4" "277.1" "274.0" "" "" "" "" "" "" "" "" "" "" "266.5" "242.4" "168.7" "209.5" "204.7" "184.1" "202.8" "225.6" "216.3" "246.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-496325283526098650" "False" "High" "IsMasterProtein" "O75427" "Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2" "0.000" "False" "21.269" "6" "3" "5" "3" "683" "73.4" "8.22" "18.68" "3" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "" "Pf00307, Pf13855" "4034" "ENSG00000077454" "LRCH4" "A4D2D5; hsa:4034; O75427; Q8WV85; Q96ID0" "" "" "0" "0" "1.029" "1.013" "1.058" "1.093" "0.970" "1.052" "1.108" "1.071" "0.947" "261.3" "268.7" "264.8" "276.5" "285.5" "253.4" "274.8" "289.6" "279.9" "247.3" "" "" "" "" "" "" "" "" "" "" "261.3" "227.4" "167.4" "201.6" "233.9" "196.8" "211.8" "249.0" "218.5" "222.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "21.266" "15" "5" "7" "5" "316" "34.8" "8.35" "23.74" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.051" "0.906" "1.054" "0.990" "0.883" "1.060" "1.066" "0.841" "1.058" "625.3" "657.2" "566.6" "658.9" "619.2" "551.9" "662.8" "666.5" "525.9" "661.7" "" "" "" "" "" "" "" "" "" "" "625.3" "556.0" "358.3" "480.4" "507.3" "428.6" "510.9" "573.0" "410.5" "594.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "21.254" "13" "3" "4" "3" "326" "34.8" "9.09" "16.79" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.001" "0.871" "0.978" "1.240" "0.960" "1.252" "1.283" "0.882" "0.937" "89.4" "89.4" "77.9" "87.4" "110.8" "85.8" "111.9" "114.7" "78.8" "83.8" "" "" "" "" "" "" "" "" "" "" "89.4" "75.7" "49.2" "63.8" "90.8" "66.7" "86.3" "98.6" "61.5" "75.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "21.244" "33" "6" "10" "6" "187" "21.4" "7.42" "33.96" "6" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "9" "0" "0.990" "0.687" "0.953" "1.028" "0.657" "0.963" "1.061" "0.670" "0.871" "1030.1" "1019.7" "707.7" "981.3" "1059.4" "677.3" "992.4" "1093.4" "690.6" "897.3" "" "" "" "" "" "" "" "" "" "" "1030.1" "862.7" "447.5" "715.5" "868.0" "526.0" "765.0" "940.1" "539.1" "806.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080105971862608535" "False" "High" "IsMasterProtein" "Q9BYJ9" "YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1" "0.000" "False" "21.237" "7" "5" "9" "3" "559" "60.8" "8.79" "33.30" "5" "cell organization and biogenesis;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "54915" "ENSG00000149658" "YTHDF1" "hsa:54915; Q8N3G5; Q8TBT1; Q96AN4; Q96S57; Q9BTI7; Q9BYJ9; Q9NX79" "" "" "0" "1" "1.070" "1.008" "1.069" "1.059" "1.105" "1.109" "1.088" "1.091" "1.003" "446.1" "477.3" "449.8" "476.9" "472.4" "493.0" "494.9" "485.3" "486.6" "447.5" "" "" "" "" "" "" "" "" "" "" "446.1" "403.8" "284.4" "347.7" "387.0" "382.8" "381.5" "417.2" "379.8" "402.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "21.228" "17" "4" "7" "4" "242" "27.1" "7.12" "23.30" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Methionine de novo and salvage pathway" "Regulation of the apoptosome activity; Methionine salvage pathway" "4" "0" "1.059" "1.103" "0.993" "1.076" "1.061" "1.007" "1.052" "0.979" "1.061" "206.9" "219.1" "228.3" "205.4" "222.6" "219.5" "208.3" "217.6" "202.6" "219.6" "" "" "" "" "" "" "" "" "" "" "206.9" "185.4" "144.3" "149.8" "182.4" "170.4" "160.5" "187.1" "158.1" "197.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "21.226" "17" "4" "4" "4" "354" "38.6" "6.95" "14.80" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "1.074" "0.951" "0.957" "0.978" "1.035" "0.943" "0.996" "1.023" "0.975" "179.2" "192.5" "170.5" "171.6" "175.3" "185.4" "169.0" "178.4" "183.4" "174.6" "" "" "" "" "" "" "" "" "" "" "179.2" "162.8" "107.8" "125.1" "143.6" "144.0" "130.3" "153.4" "143.1" "157.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "21.206" "11" "3" "14" "3" "256" "27.7" "7.78" "48.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Selenium micronutrient network" "Detoxification of Reactive Oxygen Species" "2" "0" "0.981" "1.059" "0.898" "1.031" "1.041" "0.973" "0.896" "1.056" "1.048" "688.0" "674.8" "728.4" "617.8" "709.4" "716.4" "669.7" "616.2" "726.2" "721.2" "" "" "" "" "" "" "" "" "" "" "688.0" "570.9" "460.6" "450.5" "581.2" "556.3" "516.2" "529.8" "566.9" "648.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "21.181" "27" "6" "8" "6" "227" "26.2" "8.82" "26.52" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.965" "1.097" "1.075" "1.092" "1.074" "1.031" "0.995" "1.061" "0.997" "464.9" "448.4" "509.9" "499.7" "507.6" "499.5" "479.2" "462.6" "493.1" "463.7" "" "" "" "" "" "" "" "" "" "" "464.9" "379.4" "322.4" "364.4" "415.9" "387.9" "369.4" "397.7" "384.9" "416.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "21.172" "28" "4" "7" "4" "181" "20.4" "8.92" "17.52" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "" "Interferon alpha/beta signaling" "1" "0" "0.958" "1.078" "0.885" "0.875" "1.044" "0.852" "0.883" "1.026" "1.037" "153.0" "146.6" "164.8" "135.4" "133.9" "159.7" "130.4" "135.0" "157.0" "158.6" "" "" "" "" "" "" "" "" "" "" "153.0" "124.0" "104.2" "98.7" "109.7" "124.0" "100.5" "116.1" "122.5" "142.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681264021479327249" "False" "High" "IsMasterProtein" "O95396" "Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens OX=9606 GN=MOCS3 PE=1 SV=1" "0.000" "False" "21.154" "13" "5" "6" "5" "460" "49.6" "6.21" "19.84" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00581, Pf00899" "27304" "ENSG00000124217" "MOCS3" "hsa:27304; O95396" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "0.918" "0.818" "0.891" "1.010" "0.871" "0.956" "0.947" "0.831" "1.039" "234.7" "215.5" "192.0" "209.2" "237.0" "204.4" "224.3" "222.1" "194.9" "243.8" "" "" "" "" "" "" "" "" "" "" "234.7" "182.3" "121.4" "152.5" "194.2" "158.7" "172.9" "191.0" "152.2" "219.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "High" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.000" "False" "21.152" "12" "6" "7" "6" "501" "55.8" "4.77" "17.22" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "1.251" "1.302" "1.196" "1.230" "1.447" "1.106" "1.150" "1.285" "1.241" "154.2" "192.8" "200.7" "184.4" "189.5" "223.1" "170.5" "177.3" "198.2" "191.3" "" "" "" "" "" "" "" "" "" "" "154.2" "163.1" "126.9" "134.5" "155.3" "173.3" "131.4" "152.5" "154.7" "172.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "21.135" "9" "6" "9" "6" "578" "63.1" "5.67" "28.18" "6" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "1.069" "1.041" "0.918" "0.884" "0.898" "0.871" "1.010" "1.022" "0.944" "442.2" "472.6" "460.4" "405.8" "390.8" "397.1" "385.4" "446.5" "452.0" "417.6" "" "" "" "" "" "" "" "" "" "" "442.2" "399.8" "291.1" "295.9" "320.2" "308.4" "297.1" "383.9" "352.8" "375.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "21.124" "7" "6" "8" "6" "847" "94.1" "6.23" "25.77" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "13" "0" "0.950" "0.863" "1.001" "0.982" "0.830" "0.961" "0.982" "0.810" "0.883" "473.0" "449.3" "408.2" "473.5" "464.4" "392.4" "454.7" "464.7" "383.0" "417.6" "" "" "" "" "" "" "" "" "" "" "473.0" "380.2" "258.1" "345.3" "380.5" "304.7" "350.5" "399.5" "299.0" "375.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "21.115" "20" "4" "8" "4" "288" "31.7" "7.66" "20.35" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "" "Nicotinamide salvaging" "1" "0" "1.080" "1.312" "1.090" "1.170" "1.152" "0.977" "1.142" "1.227" "1.445" "148.2" "160.1" "194.5" "161.6" "173.4" "170.7" "144.8" "169.2" "181.9" "214.2" "" "" "" "" "" "" "" "" "" "" "148.2" "135.4" "123.0" "117.8" "142.1" "132.6" "111.6" "145.5" "142.0" "192.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "21.114" "6" "7" "9" "7" "963" "105.0" "7.05" "24.72" "7" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron metabolism in placenta; Ferroptosis" "Iron uptake and transport" "3" "0" "1.055" "0.996" "1.036" "1.007" "1.011" "0.974" "1.063" "1.049" "1.005" "610.7" "644.5" "608.3" "632.8" "615.3" "617.3" "594.6" "649.3" "640.5" "613.9" "" "" "" "" "" "" "" "" "" "" "610.7" "545.3" "384.7" "461.4" "504.1" "479.4" "458.4" "558.2" "499.9" "552.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "High" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.000" "False" "21.099" "15" "7" "7" "7" "517" "57.3" "6.70" "19.44" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "1.024" "0.781" "1.104" "1.080" "0.810" "1.077" "1.064" "0.823" "0.995" "729.2" "747.0" "569.5" "805.1" "787.5" "590.7" "785.3" "776.1" "600.0" "725.3" "" "" "" "" "" "" "" "" "" "" "729.2" "632.0" "360.1" "587.0" "645.2" "458.7" "605.3" "667.3" "468.3" "652.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "21.054" "15" "6" "8" "6" "351" "40.6" "8.79" "27.21" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; Regulation of PLK1 Activity at G2/M Transition; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; RET signaling; VEGFA-VEGFR2 Pathway; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Mitochondrial protein degradation; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "75" "0" "1.015" "1.109" "1.125" "0.980" "0.993" "0.957" "1.044" "1.110" "0.950" "650.8" "660.8" "721.9" "732.3" "637.5" "646.2" "622.7" "679.2" "722.1" "618.1" "" "" "" "" "" "" "" "" "" "" "650.8" "559.0" "456.4" "533.9" "522.3" "501.8" "480.0" "584.0" "563.7" "555.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "21.050" "18" "3" "7" "3" "215" "24.9" "5.74" "18.79" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "20" "0" "1.035" "1.076" "0.994" "1.048" "1.006" "0.982" "0.973" "0.973" "1.001" "214.9" "222.5" "231.2" "213.7" "225.3" "216.3" "211.0" "209.0" "209.2" "215.2" "" "" "" "" "" "" "" "" "" "" "214.9" "188.2" "146.2" "155.8" "184.6" "168.0" "162.6" "179.7" "163.3" "193.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "988734972597675031" "False" "High" "IsMasterProtein" "P01833" "Polymeric immunoglobulin receptor OS=Homo sapiens OX=9606 GN=PIGR PE=1 SV=4" "0.000" "False" "21.044" "4" "2" "4" "2" "764" "83.2" "5.74" "16.65" "2" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07686" "5284" "ENSG00000162896" "PIGR" "hsa:5284; P01833; Q68D81; Q8IZY7" "" "Neutrophil degranulation" "1" "0" "1.073" "1.110" "1.057" "1.081" "0.958" "1.101" "1.089" "0.947" "1.015" "190.4" "204.3" "211.2" "201.2" "205.7" "182.4" "209.5" "207.3" "180.3" "193.3" "" "" "" "" "" "" "" "" "" "" "190.4" "172.9" "133.6" "146.7" "168.5" "141.7" "161.5" "178.2" "140.7" "173.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "21.041" "40" "6" "11" "6" "151" "17.2" "10.54" "28.41" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Selenocysteine synthesis; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.856" "1.143" "1.354" "0.834" "1.127" "1.150" "1.057" "1.126" "0.865" "187.7" "160.7" "214.6" "254.2" "156.5" "211.5" "215.8" "198.3" "211.4" "162.4" "" "" "" "" "" "" "" "" "" "" "187.7" "135.9" "135.7" "185.3" "128.2" "164.2" "166.4" "170.5" "165.0" "146.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "20.997" "9" "5" "9" "5" "508" "56.0" "7.11" "32.76" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.005" "0.756" "1.031" "0.899" "0.798" "1.004" "0.976" "0.808" "0.915" "516.3" "519.1" "390.2" "532.1" "463.9" "411.9" "518.4" "503.8" "417.1" "472.6" "" "" "" "" "" "" "" "" "" "" "516.3" "439.1" "246.7" "388.0" "380.1" "319.8" "399.6" "433.2" "325.6" "424.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "20.994" "26" "6" "8" "6" "198" "22.4" "6.92" "26.68" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "0.944" "0.989" "0.978" "0.972" "0.970" "1.009" "1.004" "0.932" "0.943" "1065.2" "1005.6" "1053.1" "1041.6" "1035.7" "1032.9" "1074.4" "1069.1" "992.6" "1005.0" "" "" "" "" "" "" "" "" "" "" "1065.2" "850.7" "665.9" "759.5" "848.6" "802.1" "828.2" "919.2" "774.8" "903.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.000" "False" "20.987" "11" "4" "5" "4" "417" "48.1" "6.54" "17.16" "4" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "12" "0" "0.989" "1.211" "1.004" "0.923" "1.182" "0.998" "0.966" "1.133" "1.071" "235.4" "232.9" "285.2" "236.3" "217.2" "278.3" "235.1" "227.3" "266.8" "252.2" "" "" "" "" "" "" "" "" "" "" "235.4" "197.1" "180.3" "172.3" "178.0" "216.1" "181.2" "195.5" "208.2" "226.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "20.982" "25" "5" "7" "5" "225" "25.0" "5.69" "20.49" "5" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "6" "0" "0.970" "0.957" "0.982" "0.986" "1.059" "1.000" "1.083" "1.011" "0.983" "274.2" "265.9" "262.3" "269.1" "270.4" "290.4" "274.2" "296.9" "277.2" "269.6" "" "" "" "" "" "" "" "" "" "" "274.2" "225.0" "165.8" "196.2" "221.5" "225.5" "211.4" "255.3" "216.4" "242.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "20.948" "3" "3" "5" "3" "1268" "137.3" "6.67" "18.60" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.063" "1.073" "1.088" "1.057" "1.024" "1.132" "1.154" "1.062" "1.045" "203.9" "216.8" "218.7" "221.8" "215.4" "208.7" "230.7" "235.3" "216.4" "213.1" "" "" "" "" "" "" "" "" "" "" "203.9" "183.4" "138.3" "161.7" "176.5" "162.1" "177.9" "202.3" "168.9" "191.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "20.934" "5" "5" "6" "5" "1118" "121.8" "8.88" "21.83" "5" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.133" "1.016" "1.101" "1.084" "1.264" "1.042" "1.219" "1.204" "1.110" "222.5" "252.2" "226.0" "245.0" "241.2" "281.3" "231.8" "271.2" "267.8" "246.9" "" "" "" "" "" "" "" "" "" "" "222.5" "213.4" "142.9" "178.6" "197.6" "218.4" "178.7" "233.1" "209.0" "222.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "20.930" "19" "4" "7" "4" "222" "24.7" "8.25" "18.41" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "10" "0" "1.244" "1.137" "0.923" "1.215" "1.347" "1.099" "1.038" "1.135" "1.130" "255.7" "318.1" "290.6" "236.0" "310.8" "344.5" "281.1" "265.4" "290.3" "289.0" "" "" "" "" "" "" "" "" "" "" "255.7" "269.2" "183.7" "172.1" "254.6" "267.5" "216.6" "228.2" "226.6" "259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5647730209445312513" "False" "High" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "0.000" "False" "20.920" "5" "4" "5" "2" "736" "82.8" "9.14" "18.45" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "0" "1.077" "0.936" "1.134" "1.125" "0.939" "1.225" "1.076" "0.854" "0.971" "64.7" "69.7" "60.6" "73.4" "72.8" "60.8" "79.3" "69.6" "55.3" "62.8" "" "" "" "" "" "" "" "" "" "" "64.7" "59.0" "38.3" "53.5" "59.7" "47.2" "61.2" "59.9" "43.2" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "20.913" "17" "6" "6" "6" "306" "32.4" "9.17" "20.36" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "1.005" "0.884" "0.934" "0.987" "0.956" "1.068" "0.967" "0.845" "1.010" "344.8" "346.7" "304.8" "322.2" "340.2" "329.8" "368.2" "333.4" "291.4" "348.1" "" "" "" "" "" "" "" "" "" "" "344.8" "293.3" "192.7" "234.9" "278.7" "256.1" "283.8" "286.6" "227.5" "313.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "20.862" "13" "4" "5" "4" "335" "36.0" "9.28" "17.37" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.063" "1.082" "1.013" "1.019" "1.080" "0.991" "1.024" "1.045" "1.153" "302.9" "322.0" "327.7" "306.7" "308.7" "327.2" "300.3" "310.0" "316.5" "349.1" "" "" "" "" "" "" "" "" "" "" "302.9" "272.4" "207.2" "223.6" "252.9" "254.1" "231.5" "266.5" "247.1" "313.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "20.861" "7" "3" "4" "3" "503" "51.2" "11.47" "15.89" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "5" "0" "0.860" "1.050" "1.061" "1.010" "1.093" "1.097" "0.934" "1.030" "1.061" "182.4" "156.8" "191.5" "193.6" "184.2" "199.4" "200.0" "170.4" "188.0" "193.5" "" "" "" "" "" "" "" "" "" "" "182.4" "132.7" "121.1" "141.2" "150.9" "154.8" "154.2" "146.5" "146.7" "174.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "20.844" "3" "2" "3" "2" "976" "111.0" "6.43" "14.40" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "10q11.21q11.23 copy number variation syndrome" "POLB-Dependent Long Patch Base Excision Repair" "2" "0" "0.910" "0.758" "1.007" "1.004" "0.944" "0.972" "1.181" "0.909" "0.996" "60.3" "54.9" "45.7" "60.8" "60.6" "56.9" "58.6" "71.3" "54.9" "60.1" "" "" "" "" "" "" "" "" "" "" "60.3" "46.4" "28.9" "44.3" "49.6" "44.2" "45.2" "61.3" "42.8" "54.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "20.826" "13" "4" "4" "2" "406" "46.2" "6.99" "15.58" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Regulation of actin cytoskeleton; G13 signaling pathway" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "0" "1.004" "0.974" "1.099" "0.972" "0.996" "1.051" "1.021" "1.054" "1.010" "169.9" "170.6" "165.4" "186.6" "165.2" "169.3" "178.6" "173.4" "179.0" "171.6" "" "" "" "" "" "" "" "" "" "" "169.9" "144.3" "104.6" "136.1" "135.3" "131.5" "137.7" "149.1" "139.7" "154.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.000" "False" "20.818" "10" "5" "6" "5" "602" "69.9" "8.13" "15.92" "5" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "33" "0" "1.110" "0.962" "0.953" "0.920" "1.054" "1.000" "0.974" "0.968" "0.997" "249.3" "276.8" "239.9" "237.5" "229.3" "262.7" "249.3" "242.8" "241.3" "248.5" "" "" "" "" "" "" "" "" "" "" "249.3" "234.2" "151.7" "173.2" "187.8" "204.0" "192.2" "208.7" "188.4" "223.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387736998001173674" "False" "High" "IsMasterProtein" "Q969T4" "Ubiquitin-conjugating enzyme E2 E3 OS=Homo sapiens OX=9606 GN=UBE2E3 PE=1 SV=1" "0.000" "False" "20.805" "19" "3" "6" "2" "207" "22.9" "7.18" "18.63" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "10477" "ENSG00000170035" "UBE2E3" "B2RAD6; D3DPG3; hsa:10477; Q5U0R7; Q7Z4W4; Q969T4" "7q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "3" "0" "0.980" "1.222" "1.047" "1.040" "1.147" "1.196" "1.005" "1.076" "0.967" "120.7" "118.3" "147.5" "126.4" "125.5" "138.5" "144.4" "121.3" "130.0" "116.8" "" "" "" "" "" "" "" "" "" "" "120.7" "100.1" "93.3" "92.2" "102.9" "107.6" "111.3" "104.3" "101.4" "105.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "20.791" "26" "4" "5" "4" "156" "17.7" "10.45" "17.44" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.859" "1.336" "0.957" "1.131" "1.353" "1.022" "1.185" "1.320" "1.118" "360.6" "309.9" "481.8" "345.1" "408.0" "488.0" "368.7" "427.3" "476.1" "403.1" "" "" "" "" "" "" "" "" "" "" "360.6" "262.2" "304.7" "251.6" "334.3" "379.0" "284.2" "367.4" "371.7" "362.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "20.746" "5" "4" "5" "3" "898" "103.3" "5.80" "17.70" "4" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "20.740" "10" "5" "5" "5" "492" "57.2" "5.92" "16.23" "5" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.980" "0.855" "0.915" "0.966" "0.882" "0.982" "0.958" "0.867" "0.931" "385.7" "378.0" "329.8" "353.0" "372.7" "340.4" "378.7" "369.7" "334.6" "358.9" "" "" "" "" "" "" "" "" "" "" "385.7" "319.8" "208.5" "257.4" "305.3" "264.3" "291.9" "317.8" "261.2" "322.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "20.734" "11" "5" "6" "5" "531" "59.9" "5.35" "20.02" "5" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; Protein methylation" "3" "0" "1.049" "1.068" "1.146" "1.003" "1.033" "1.020" "1.050" "1.113" "1.187" "139.1" "145.9" "148.5" "159.4" "139.5" "143.7" "142.0" "146.1" "154.8" "165.1" "" "" "" "" "" "" "" "" "" "" "139.1" "123.4" "93.9" "116.2" "114.3" "111.6" "109.4" "125.6" "120.8" "148.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "20.731" "15" "3" "9" "3" "218" "25.0" "4.93" "26.73" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.117" "1.158" "1.036" "1.037" "0.976" "1.070" "1.003" "1.052" "1.037" "216.3" "241.5" "250.5" "224.0" "224.3" "211.1" "231.4" "217.0" "227.6" "224.2" "" "" "" "" "" "" "" "" "" "" "216.3" "204.3" "158.4" "163.4" "183.8" "163.9" "178.4" "186.6" "177.7" "201.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "20.695" "8" "5" "5" "5" "587" "65.2" "6.93" "16.55" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Selenium micronutrient network; Folate metabolism" "Vitamin B2 (riboflavin) metabolism" "3" "0" "0.986" "0.919" "1.017" "1.053" "0.901" "0.941" "1.009" "0.992" "1.029" "287.3" "283.4" "264.2" "292.3" "302.4" "258.8" "270.2" "289.8" "284.9" "295.5" "" "" "" "" "" "" "" "" "" "" "287.3" "239.7" "167.0" "213.1" "247.8" "200.9" "208.3" "249.2" "222.3" "265.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "20.670" "12" "3" "3" "3" "356" "38.5" "7.39" "12.03" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "" "Processing of SMDT1; Cellular response to mitochondrial stress" "2" "0" "1.092" "1.112" "1.061" "1.207" "1.127" "1.129" "1.129" "1.109" "1.081" "160.5" "175.3" "178.5" "170.3" "193.8" "180.9" "181.1" "181.2" "178.0" "173.6" "" "" "" "" "" "" "" "" "" "" "160.5" "148.3" "112.8" "124.2" "158.8" "140.5" "139.6" "155.8" "139.0" "156.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "20.655" "21" "4" "8" "2" "198" "22.4" "6.11" "24.36" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly" "10" "0" "0.857" "1.001" "0.901" "0.908" "1.029" "1.013" "0.998" "0.869" "0.886" "408.4" "349.9" "408.6" "368.0" "370.7" "420.1" "413.9" "407.5" "354.9" "362.0" "" "" "" "" "" "" "" "" "" "" "408.4" "296.0" "258.4" "268.3" "303.7" "326.2" "319.1" "350.4" "277.0" "325.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "20.652" "12" "4" "7" "4" "336" "39.1" "4.81" "25.41" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.918" "0.728" "0.887" "1.016" "0.809" "0.940" "0.968" "0.771" "0.916" "374.5" "343.8" "272.7" "332.3" "380.4" "303.1" "351.9" "362.4" "288.6" "343.0" "" "" "" "" "" "" "" "" "" "" "374.5" "290.9" "172.4" "242.3" "311.6" "235.4" "271.2" "311.6" "225.3" "308.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "20.636" "9" "6" "10" "6" "645" "73.5" "8.02" "27.59" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.001" "0.970" "0.960" "1.029" "1.033" "0.973" "1.013" "0.974" "1.045" "259.1" "259.3" "251.5" "248.7" "266.6" "267.7" "252.1" "262.6" "252.5" "270.8" "" "" "" "" "" "" "" "" "" "" "259.1" "219.4" "159.0" "181.3" "218.5" "207.9" "194.3" "225.8" "197.1" "243.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "High" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.000" "False" "20.630" "4" "6" "6" "6" "1634" "184.7" "7.30" "17.99" "6" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Synthesis of PIPs at the plasma membrane" "8" "0" "0.904" "0.854" "0.976" "1.088" "0.859" "1.081" "0.997" "0.811" "1.173" "63.4" "57.4" "54.2" "61.9" "69.0" "54.5" "68.6" "63.2" "51.4" "74.4" "" "" "" "" "" "" "" "" "" "" "63.4" "48.5" "34.3" "45.1" "56.6" "42.3" "52.9" "54.4" "40.2" "66.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "20.610" "15" "4" "5" "4" "297" "33.7" "7.14" "18.63" "4" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "" "ERBB2 Regulates Cell Motility" "1" "0" "1.081" "1.031" "1.028" "1.049" "1.133" "0.985" "1.074" "1.004" "1.093" "189.8" "205.2" "195.7" "195.1" "199.1" "215.1" "187.0" "203.8" "190.7" "207.4" "" "" "" "" "" "" "" "" "" "" "189.8" "173.6" "123.7" "142.3" "163.1" "167.0" "144.1" "175.2" "148.8" "186.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165152486354207968" "False" "High" "IsMasterProtein" "O75037" "Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2" "0.000" "False" "20.609" "3" "4" "7" "2" "1637" "182.5" "7.08" "23.76" "4" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "23046" "ENSG00000116852" "KIF21B" "B2RP62; B7ZMI0; hsa:23046; O75037; Q5T4J3" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.151" "0.825" "1.091" "1.164" "1.164" "1.502" "1.122" "0.927" "1.124" "45.0" "51.8" "37.1" "49.1" "52.4" "52.4" "67.6" "50.5" "41.7" "50.6" "" "" "" "" "" "" "" "" "" "" "45.0" "43.8" "23.5" "35.8" "42.9" "40.7" "52.1" "43.4" "32.6" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4224605817431316350" "False" "High" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "0.000" "False" "20.603" "11" "8" "10" "8" "819" "91.9" "4.69" "27.51" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "1.086" "2.181" "1.054" "1.046" "2.377" "1.097" "0.911" "1.880" "1.247" "62.6" "68.0" "136.5" "65.9" "65.5" "148.8" "68.7" "57.0" "117.7" "78.1" "" "" "" "" "" "" "" "" "" "" "62.6" "57.5" "86.3" "48.1" "53.6" "115.5" "52.9" "49.0" "91.8" "70.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "20.589" "20" "6" "7" "6" "275" "30.3" "7.50" "21.96" "6" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "1.104" "1.225" "1.305" "1.145" "1.149" "1.350" "1.239" "1.297" "1.187" "64.1" "70.7" "78.5" "83.6" "73.3" "73.6" "86.5" "79.4" "83.1" "76.0" "" "" "" "" "" "" "" "" "" "" "64.1" "59.8" "49.6" "61.0" "60.1" "57.2" "66.7" "68.3" "64.8" "68.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-789511479774361380" "False" "High" "IsMasterProtein" "Q14202" "Zinc finger MYM-type protein 3 OS=Homo sapiens OX=9606 GN=ZMYM3 PE=1 SV=2" "0.000" "False" "20.576" "4" "5" "6" "5" "1370" "152.3" "6.35" "18.02" "5" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9203" "ENSG00000147130" "ZMYM3" "D3DVV3; hsa:9203; O15089; Q14202; Q96E26" "Orexin receptor pathway" "" "1" "0" "0.923" "0.718" "0.996" "1.013" "0.849" "0.898" "1.105" "0.759" "0.933" "163.4" "150.8" "117.3" "162.8" "165.6" "138.8" "146.7" "180.5" "124.0" "152.5" "" "" "" "" "" "" "" "" "" "" "163.4" "127.6" "74.1" "118.7" "135.7" "107.8" "113.1" "155.2" "96.8" "137.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550232429458165552" "False" "High" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "0.000" "False" "20.560" "9" "7" "7" "6" "838" "97.0" "7.93" "14.54" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "1" "0.947" "0.613" "0.968" "0.988" "0.622" "0.891" "0.965" "0.634" "0.862" "354.2" "335.5" "217.2" "342.9" "350.0" "220.4" "315.7" "341.7" "224.5" "305.3" "" "" "" "" "" "" "" "" "" "" "354.2" "283.9" "137.3" "250.0" "286.7" "171.1" "243.4" "293.8" "175.2" "274.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "20.547" "30" "3" "6" "3" "123" "13.9" "5.52" "25.87" "3" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "0.985" "0.904" "0.960" "0.989" "0.996" "0.922" "0.899" "0.942" "1.000" "217.5" "214.2" "196.6" "208.8" "215.1" "216.6" "200.5" "195.6" "204.9" "217.5" "" "" "" "" "" "" "" "" "" "" "217.5" "181.2" "124.3" "152.2" "176.2" "168.2" "154.6" "168.2" "159.9" "195.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "20.542" "8" "6" "6" "6" "907" "103.5" "8.12" "18.26" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.290" "0.948" "1.132" "1.244" "1.013" "1.163" "1.317" "0.927" "1.134" "141.4" "182.5" "134.1" "160.1" "175.9" "143.2" "164.4" "186.2" "131.1" "160.3" "" "" "" "" "" "" "" "" "" "" "141.4" "154.4" "84.8" "116.7" "144.1" "111.2" "126.8" "160.1" "102.3" "144.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "20.523" "10" "6" "11" "3" "552" "59.7" "9.04" "35.59" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "1.027" "0.868" "1.076" "1.193" "0.996" "1.007" "0.933" "0.972" "1.067" "169.5" "174.1" "147.2" "182.4" "202.2" "168.9" "170.6" "158.1" "164.8" "180.9" "" "" "" "" "" "" "" "" "" "" "169.5" "147.3" "93.1" "133.0" "165.6" "131.2" "131.5" "135.9" "128.6" "162.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "20.486" "10" "3" "5" "3" "306" "33.9" "8.59" "16.19" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "0.934" "0.806" "0.977" "0.995" "0.859" "1.044" "1.023" "0.856" "0.875" "206.8" "193.1" "166.8" "202.0" "205.8" "177.6" "215.9" "211.5" "177.0" "180.9" "" "" "" "" "" "" "" "" "" "" "206.8" "163.4" "105.5" "147.3" "168.6" "138.0" "166.5" "181.9" "138.2" "162.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "20.485" "35" "4" "11" "4" "130" "15.0" "5.02" "33.64" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "Apoptosis modulation and signaling" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "3" "0" "1.067" "0.982" "1.133" "1.101" "1.022" "1.211" "1.106" "0.974" "1.058" "330.8" "352.8" "324.9" "374.7" "364.2" "338.0" "400.5" "365.8" "322.1" "350.0" "" "" "" "" "" "" "" "" "" "" "330.8" "298.5" "205.5" "273.2" "298.4" "262.5" "308.7" "314.5" "251.4" "314.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "20.465" "15" "4" "5" "4" "291" "32.4" "9.10" "17.71" "4" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "0.979" "1.022" "1.086" "1.062" "1.136" "1.158" "0.909" "1.076" "0.997" "338.3" "331.2" "345.8" "367.3" "359.5" "384.2" "391.9" "307.5" "364.2" "337.4" "" "" "" "" "" "" "" "" "" "" "338.3" "280.2" "218.6" "267.8" "294.5" "298.4" "302.1" "264.4" "284.3" "303.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "20.456" "8" "6" "8" "6" "723" "83.5" "5.94" "22.45" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Intracellular trafficking proteins involved in CMT neuropathy" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.076" "0.630" "0.990" "0.995" "0.728" "0.979" "0.988" "0.774" "0.888" "115.7" "124.5" "72.9" "114.6" "115.1" "84.3" "113.3" "114.3" "89.5" "102.8" "" "" "" "" "" "" "" "" "" "" "115.7" "105.3" "46.1" "83.5" "94.3" "65.4" "87.3" "98.3" "69.9" "92.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "20.442" "4" "6" "6" "6" "1451" "164.0" "5.88" "18.66" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "7" "0" "1.013" "0.720" "0.950" "1.089" "0.763" "1.000" "1.136" "0.724" "1.037" "207.6" "210.2" "149.6" "197.3" "226.2" "158.3" "207.6" "235.7" "150.3" "215.2" "" "" "" "" "" "" "" "" "" "" "207.6" "177.9" "94.6" "143.9" "185.3" "123.0" "160.0" "202.7" "117.4" "193.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "20.433" "5" "5" "5" "5" "1101" "128.7" "8.38" "16.05" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.104" "1.040" "1.128" "1.070" "1.081" "1.078" "1.286" "1.032" "1.173" "37.9" "41.8" "39.4" "42.7" "40.5" "40.9" "40.8" "48.7" "39.1" "44.4" "" "" "" "" "" "" "" "" "" "" "37.9" "35.4" "24.9" "31.2" "33.2" "31.8" "31.5" "41.9" "30.5" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.000" "False" "20.386" "17" "3" "11" "2" "201" "22.2" "7.71" "30.93" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.035" "1.346" "1.558" "1.266" "1.892" "1.385" "1.203" "1.461" "1.049" "97.2" "100.6" "130.8" "151.4" "123.1" "183.9" "134.6" "116.9" "142.0" "102.0" "" "" "" "" "" "" "" "" "" "" "97.2" "85.1" "82.7" "110.4" "100.8" "142.8" "103.7" "100.5" "110.9" "91.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "20.358" "7" "2" "4" "2" "375" "42.2" "7.64" "16.02" "2" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "1.145" "1.129" "1.182" "1.195" "1.160" "0.937" "0.979" "1.086" "1.145" "114.5" "131.1" "129.3" "135.3" "136.8" "132.8" "107.3" "112.0" "124.4" "131.1" "" "" "" "" "" "" "" "" "" "" "114.5" "111.0" "81.7" "98.7" "112.1" "103.1" "82.7" "96.3" "97.1" "117.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "20.337" "9" "4" "6" "4" "565" "65.3" "8.91" "18.55" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "" "mRNA Splicing - Major Pathway" "1" "0" "1.169" "1.154" "1.119" "1.163" "1.265" "1.194" "1.217" "1.112" "1.130" "208.6" "243.8" "240.7" "233.4" "242.5" "263.9" "249.2" "254.0" "231.9" "235.7" "" "" "" "" "" "" "" "" "" "" "208.6" "206.3" "152.2" "170.2" "198.7" "204.9" "192.1" "218.4" "181.0" "211.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "20.308" "21" "3" "4" "3" "166" "19.2" "9.45" "17.05" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.991" "1.083" "0.890" "1.014" "1.121" "0.995" "0.949" "1.035" "1.091" "385.5" "382.2" "417.5" "342.9" "391.0" "432.3" "383.7" "365.9" "399.0" "420.4" "" "" "" "" "" "" "" "" "" "" "385.5" "323.4" "264.0" "250.1" "320.4" "335.8" "295.8" "314.6" "311.4" "378.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "20.276" "10" "3" "5" "3" "349" "40.3" "5.57" "17.00" "3" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "Cellular response to hypoxia" "3" "0" "1.111" "0.946" "1.222" "1.014" "0.813" "1.231" "0.936" "0.911" "0.850" "51.8" "57.5" "49.0" "63.3" "52.5" "42.1" "63.7" "48.4" "47.2" "44.0" "" "" "" "" "" "" "" "" "" "" "51.8" "48.7" "31.0" "46.1" "43.0" "32.7" "49.1" "41.7" "36.8" "39.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "20.270" "13" "5" "7" "5" "455" "51.8" "6.35" "19.51" "5" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.857" "1.041" "1.002" "0.911" "1.148" "0.972" "0.762" "1.050" "0.905" "414.1" "354.9" "431.0" "415.1" "377.2" "475.4" "402.3" "315.7" "434.9" "374.8" "" "" "" "" "" "" "" "" "" "" "414.1" "300.3" "272.5" "302.7" "309.0" "369.2" "310.1" "271.5" "339.4" "337.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.000" "False" "20.269" "7" "4" "5" "4" "591" "67.2" "6.27" "15.65" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.879" "0.825" "0.837" "0.905" "0.833" "0.885" "0.904" "0.780" "0.964" "174.8" "153.6" "144.2" "146.3" "158.2" "145.5" "154.7" "158.0" "136.2" "168.4" "" "" "" "" "" "" "" "" "" "" "174.8" "130.0" "91.1" "106.7" "129.6" "113.0" "119.3" "135.9" "106.3" "151.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "20.261" "20" "4" "5" "4" "182" "20.4" "7.24" "17.48" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "5" "0" "1.042" "1.087" "1.148" "1.058" "1.012" "1.100" "1.062" "0.990" "0.994" "192.7" "200.7" "209.4" "221.1" "203.8" "195.0" "212.0" "204.6" "190.8" "191.5" "" "" "" "" "" "" "" "" "" "" "192.7" "169.8" "132.4" "161.2" "167.0" "151.5" "163.4" "176.0" "149.0" "172.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4094952149974440381" "False" "High" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "0.000" "False" "20.259" "10" "4" "8" "4" "528" "57.2" "9.03" "23.04" "4" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.041" "0.814" "1.027" "1.016" "0.842" "1.061" "1.027" "0.865" "0.978" "454.3" "472.7" "369.6" "466.8" "461.4" "382.4" "482.2" "466.5" "392.8" "444.3" "" "" "" "" "" "" "" "" "" "" "454.3" "400.0" "233.7" "340.3" "378.1" "297.0" "371.7" "401.1" "306.6" "399.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "20.247" "3" "7" "8" "6" "2426" "263.7" "5.64" "23.30" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "0.844" "0.855" "1.058" "0.897" "0.920" "1.182" "0.937" "0.808" "0.845" "462.2" "389.9" "395.3" "489.1" "414.5" "425.3" "546.5" "432.9" "373.6" "390.5" "" "" "" "" "" "" "" "" "" "" "462.2" "329.9" "250.0" "356.6" "339.6" "330.3" "421.3" "372.2" "291.6" "351.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "20.244" "4" "7" "8" "6" "1390" "155.5" "8.48" "25.48" "7" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "9" "1" "0.985" "1.049" "1.014" "1.053" "1.032" "1.056" "1.056" "1.041" "1.051" "370.7" "365.3" "389.0" "376.0" "390.2" "382.6" "391.4" "391.3" "386.0" "389.4" "" "" "" "" "" "" "" "" "" "" "370.7" "309.1" "246.0" "274.2" "319.7" "297.2" "301.7" "336.5" "301.3" "350.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "20.199" "11" "2" "5" "2" "298" "34.8" "8.00" "22.86" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.226" "1.040" "1.102" "1.147" "1.121" "1.285" "1.134" "1.072" "1.255" "186.2" "228.3" "193.6" "205.1" "213.7" "208.7" "239.2" "211.2" "199.6" "233.6" "" "" "" "" "" "" "" "" "" "" "186.2" "193.1" "122.4" "149.6" "175.0" "162.1" "184.4" "181.6" "155.8" "210.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "20.195" "29" "5" "9" "5" "204" "22.9" "9.72" "28.16" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.904" "0.993" "0.984" "0.941" "1.114" "1.124" "1.025" "1.075" "1.002" "280.6" "253.7" "278.7" "276.1" "263.9" "312.5" "315.4" "287.7" "301.5" "281.2" "" "" "" "" "" "" "" "" "" "" "280.6" "214.6" "176.2" "201.3" "216.2" "242.6" "243.1" "247.4" "235.4" "252.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "20.184" "11" "5" "5" "5" "507" "55.4" "7.02" "17.16" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.243" "1.124" "1.074" "1.041" "1.375" "1.455" "1.246" "1.337" "1.268" "25.7" "32.0" "28.9" "27.6" "26.8" "35.3" "37.4" "32.1" "34.4" "32.6" "" "" "" "" "" "" "" "" "" "" "25.7" "27.0" "18.3" "20.1" "21.9" "27.5" "28.8" "27.6" "26.8" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "20.132" "12" "3" "7" "3" "337" "38.8" "5.34" "24.08" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "" "Platelet degranulation" "1" "0" "0.978" "1.025" "1.133" "1.101" "1.048" "1.063" "1.021" "1.090" "1.057" "258.6" "252.9" "265.0" "293.0" "284.6" "270.9" "274.8" "264.1" "281.8" "273.3" "" "" "" "" "" "" "" "" "" "" "258.6" "213.9" "167.6" "213.6" "233.1" "210.3" "211.8" "227.0" "220.0" "245.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "20.130" "16" "5" "9" "5" "326" "36.7" "5.92" "27.35" "5" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.988" "0.811" "0.918" "0.946" "0.886" "0.934" "0.993" "0.838" "0.980" "528.4" "522.3" "428.4" "485.3" "499.7" "468.3" "493.5" "524.7" "443.1" "517.9" "" "" "" "" "" "" "" "" "" "" "528.4" "441.9" "270.9" "353.9" "409.4" "363.7" "380.4" "451.1" "345.8" "465.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "20.123" "11" "5" "7" "5" "395" "42.5" "4.86" "19.80" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "" "3" "0" "1.081" "0.982" "0.961" "0.995" "0.971" "0.984" "0.972" "1.019" "0.956" "616.1" "666.0" "604.9" "592.1" "613.2" "598.1" "606.2" "599.0" "627.8" "589.3" "" "" "" "" "" "" "" "" "" "" "616.1" "563.5" "382.5" "431.7" "502.4" "464.4" "467.3" "515.0" "490.1" "529.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "20.107" "14" "6" "7" "6" "542" "63.2" "5.11" "17.16" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "" "Protein hydroxylation" "1" "0" "1.087" "1.141" "1.091" "1.114" "1.196" "1.206" "1.168" "1.019" "1.010" "84.5" "91.8" "96.5" "92.2" "94.1" "101.1" "101.9" "98.7" "86.1" "85.4" "" "" "" "" "" "" "" "" "" "" "84.5" "77.7" "61.0" "67.2" "77.1" "78.5" "78.5" "84.9" "67.2" "76.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "20.100" "18" "4" "7" "4" "305" "33.6" "5.47" "23.31" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "5" "0" "1.170" "1.137" "1.054" "1.171" "1.274" "1.245" "1.341" "1.216" "1.148" "232.2" "271.6" "264.0" "244.9" "272.0" "295.8" "289.0" "311.5" "282.3" "266.5" "" "" "" "" "" "" "" "" "" "" "232.2" "229.8" "166.9" "178.5" "222.9" "229.7" "222.8" "267.8" "220.3" "239.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "20.090" "10" "4" "4" "4" "528" "60.6" "5.06" "13.88" "4" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.087" "0.892" "1.031" "1.024" "1.041" "1.094" "1.015" "1.017" "1.025" "121.1" "131.7" "108.0" "124.8" "124.0" "126.0" "132.5" "123.0" "123.2" "124.1" "" "" "" "" "" "" "" "" "" "" "121.1" "111.4" "68.3" "91.0" "101.6" "97.9" "102.1" "105.7" "96.2" "111.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "20.080" "13" "4" "5" "4" "350" "40.3" "6.96" "18.56" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "3" "0" "1.054" "1.073" "0.900" "1.250" "1.287" "1.138" "1.026" "1.218" "1.231" "71.7" "75.6" "77.0" "64.5" "89.6" "92.3" "81.6" "73.6" "87.3" "88.3" "" "" "" "" "" "" "" "" "" "" "71.7" "64.0" "48.7" "47.1" "73.4" "71.7" "62.9" "63.3" "68.2" "79.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "20.073" "31" "4" "6" "4" "118" "13.7" "8.79" "18.22" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Osteoclast signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.031" "1.009" "0.885" "0.910" "1.050" "1.037" "0.969" "1.095" "0.973" "444.8" "458.6" "448.9" "393.4" "404.9" "467.0" "461.3" "430.9" "487.0" "433.0" "" "" "" "" "" "" "" "" "" "" "444.8" "388.0" "283.8" "286.9" "331.8" "362.7" "355.6" "370.5" "380.2" "389.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "20.002" "10" "6" "6" "6" "597" "67.6" "5.85" "17.72" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.021" "0.997" "1.063" "1.068" "0.978" "1.003" "0.992" "0.993" "1.142" "218.4" "222.9" "217.6" "232.2" "233.2" "213.6" "219.1" "216.6" "216.9" "249.3" "" "" "" "" "" "" "" "" "" "" "218.4" "188.6" "137.6" "169.3" "191.1" "165.9" "168.9" "186.2" "169.3" "224.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "19.971" "25" "3" "6" "3" "159" "17.4" "9.67" "19.39" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "" "mRNA Splicing - Major Pathway" "1" "0" "0.879" "1.069" "1.063" "0.970" "1.138" "1.016" "0.988" "1.088" "1.042" "555.4" "488.3" "593.9" "590.4" "538.5" "632.0" "564.3" "548.6" "604.1" "578.9" "" "" "" "" "" "" "" "" "" "" "555.4" "413.1" "375.5" "430.5" "441.2" "490.8" "435.0" "471.7" "471.6" "520.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "19.969" "8" "3" "4" "2" "570" "62.6" "9.28" "15.96" "3" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Coenzyme A biosynthesis" "3" "1" "1.002" "0.989" "0.995" "1.133" "1.062" "1.016" "1.048" "1.038" "1.165" "201.6" "201.9" "199.4" "200.6" "228.4" "214.1" "204.8" "211.2" "209.3" "234.7" "" "" "" "" "" "" "" "" "" "" "201.6" "170.8" "126.1" "146.2" "187.1" "166.3" "157.8" "181.5" "163.4" "211.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1674300386967477261" "False" "High" "IsMasterProtein" "Q68CQ4" "U3 small nucleolar RNA-associated protein 25 homolog OS=Homo sapiens OX=9606 GN=UTP25 PE=1 SV=2" "0.000" "False" "19.961" "6" "5" "7" "5" "756" "87.0" "5.88" "21.96" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06862" "27042" "ENSG00000117597" "UTP25" "hsa:27042; O75992; Q4VY00; Q63HL9; Q68CQ4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.135" "1.293" "1.328" "1.178" "1.248" "1.114" "1.114" "1.100" "1.043" "149.6" "169.9" "193.5" "198.7" "176.2" "186.7" "166.7" "166.8" "164.6" "156.0" "" "" "" "" "" "" "" "" "" "" "149.6" "143.7" "122.4" "144.9" "144.4" "145.0" "128.5" "143.4" "128.5" "140.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "19.950" "5" "5" "5" "5" "846" "95.1" "9.00" "17.75" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "Complement system in neuronal development and plasticity" "NOTCH3 Intracellular Domain Regulates Transcription" "2" "0" "0.905" "0.520" "0.954" "0.948" "0.609" "0.974" "1.043" "0.572" "0.787" "328.3" "297.0" "170.8" "313.1" "311.0" "200.1" "319.7" "342.4" "187.8" "258.4" "" "" "" "" "" "" "" "" "" "" "328.3" "251.3" "108.0" "228.3" "254.8" "155.4" "246.4" "294.4" "146.6" "232.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "19.947" "16" "2" "8" "2" "179" "19.1" "5.50" "26.04" "2" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.044" "1.105" "1.155" "0.981" "1.013" "1.086" "0.905" "1.101" "1.083" "94.1" "98.2" "104.0" "108.7" "92.3" "95.3" "102.2" "85.2" "103.6" "101.9" "" "" "" "" "" "" "" "" "" "" "94.1" "83.1" "65.8" "79.3" "75.6" "74.0" "78.8" "73.2" "80.9" "91.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "19.933" "18" "2" "7" "2" "200" "23.0" "8.37" "24.52" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "0.965" "1.057" "1.015" "1.081" "1.117" "1.150" "0.923" "1.045" "1.070" "277.8" "268.0" "293.7" "281.9" "300.4" "310.2" "319.5" "256.5" "290.2" "297.4" "" "" "" "" "" "" "" "" "" "" "277.8" "226.7" "185.7" "205.5" "246.1" "240.9" "246.3" "220.6" "226.5" "267.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "19.931" "9" "3" "4" "3" "368" "40.9" "7.83" "14.99" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "30" "0" "0.960" "0.849" "0.963" "0.903" "0.770" "0.865" "1.017" "0.885" "0.862" "292.0" "280.4" "248.1" "281.1" "263.7" "224.9" "252.5" "297.0" "258.3" "251.6" "" "" "" "" "" "" "" "" "" "" "292.0" "237.2" "156.9" "205.0" "216.1" "174.6" "194.6" "255.4" "201.6" "226.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "19.931" "20" "4" "8" "2" "198" "22.4" "6.68" "22.87" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "2" "0.936" "1.034" "1.121" "0.916" "1.179" "1.149" "1.160" "1.045" "0.895" "248.6" "232.6" "257.1" "278.6" "227.6" "293.0" "285.5" "288.3" "259.9" "222.5" "" "" "" "" "" "" "" "" "" "" "248.6" "196.8" "162.6" "203.1" "186.5" "227.5" "220.1" "247.9" "202.9" "200.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "19.879" "3" "2" "4" "2" "838" "93.9" "6.39" "16.80" "2" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "Gastric cancer network 2" "RHOH GTPase cycle" "2" "0" "0.968" "0.940" "1.099" "0.922" "0.879" "0.995" "1.089" "0.965" "0.959" "155.8" "150.9" "146.6" "171.2" "143.6" "137.0" "155.1" "169.7" "150.3" "149.4" "" "" "" "" "" "" "" "" "" "" "155.8" "127.6" "92.7" "124.9" "117.7" "106.4" "119.6" "145.9" "117.3" "134.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "19.878" "3" "5" "7" "3" "1447" "164.6" "8.47" "25.76" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.066" "0.788" "1.039" "1.005" "0.887" "0.862" "0.921" "0.793" "0.939" "328.5" "350.1" "258.9" "341.3" "330.3" "291.4" "283.2" "302.7" "260.6" "308.6" "" "" "" "" "" "" "" "" "" "" "328.5" "296.2" "163.7" "248.9" "270.6" "226.3" "218.3" "260.2" "203.4" "277.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "High" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.000" "False" "19.876" "9" "6" "9" "5" "711" "79.1" "8.38" "26.84" "6" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "13" "1" "0.999" "0.821" "1.010" "1.014" "0.819" "0.984" "1.087" "0.808" "1.037" "518.2" "517.9" "425.3" "523.3" "525.3" "424.5" "509.9" "563.1" "418.6" "537.4" "" "" "" "" "" "" "" "" "" "" "518.2" "438.2" "268.9" "381.5" "430.4" "329.6" "393.1" "484.2" "326.7" "483.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.000" "False" "19.867" "15" "4" "5" "4" "440" "47.7" "5.22" "18.80" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "24" "0" "0.995" "1.009" "1.108" "0.901" "1.064" "1.073" "1.011" "1.030" "1.108" "168.4" "167.5" "170.0" "186.5" "151.8" "179.2" "180.7" "170.2" "173.4" "186.6" "" "" "" "" "" "" "" "" "" "" "168.4" "141.7" "107.5" "136.0" "124.4" "139.2" "139.3" "146.4" "135.3" "167.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "19.863" "8" "7" "9" "6" "825" "94.8" "6.55" "24.25" "7" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "" "Purine salvage" "1" "0" "1.024" "1.057" "1.070" "1.004" "1.151" "1.117" "1.077" "1.023" "1.078" "274.0" "280.7" "289.6" "293.2" "275.1" "315.5" "306.0" "295.1" "280.4" "295.3" "" "" "" "" "" "" "" "" "" "" "274.0" "237.4" "183.1" "213.8" "225.4" "245.0" "235.9" "253.7" "218.9" "265.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "19.835" "8" "7" "7" "7" "942" "103.9" "6.37" "18.66" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "10" "0" "1.020" "0.997" "1.009" "1.043" "1.012" "1.089" "1.092" "0.909" "1.018" "244.1" "249.0" "243.3" "246.4" "254.5" "247.1" "265.8" "266.5" "221.9" "248.5" "" "" "" "" "" "" "" "" "" "" "244.1" "210.6" "153.9" "179.6" "208.5" "191.9" "204.9" "229.1" "173.2" "223.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8113893803591480288" "False" "High" "IsMasterProtein" "Cont_Q7Z794" "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" "0.000" "True" "19.820" "7" "4" "7" "1" "578" "61.9" "5.99" "24.29" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "374454" "ENSG00000189182" "KRT77" "hsa:374454; Q7RTS8; Q7Z794" "" "Formation of the cornified envelope" "2" "0" "1.022" "1.048" "1.025" "0.983" "0.886" "1.079" "1.079" "0.977" "1.126" "103.7" "105.9" "108.7" "106.3" "101.9" "91.8" "111.9" "111.9" "101.3" "116.8" "" "" "" "" "" "" "" "" "" "" "103.7" "89.6" "68.7" "77.5" "83.5" "71.3" "86.3" "96.2" "79.1" "105.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "19.815" "9" "3" "6" "3" "393" "44.3" "5.07" "20.90" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "2q37 copy number variation syndrome" "Macroautophagy" "2" "0" "0.954" "0.872" "1.030" "0.985" "0.850" "0.976" "1.067" "0.895" "1.017" "155.7" "148.5" "135.8" "160.3" "153.3" "132.3" "151.9" "166.2" "139.4" "158.3" "" "" "" "" "" "" "" "" "" "" "155.7" "125.6" "85.9" "116.9" "125.6" "102.7" "117.1" "142.9" "108.8" "142.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "19.804" "25" "5" "5" "5" "230" "25.6" "4.82" "17.30" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "" "Vitamin B1 (thiamin) metabolism" "1" "0" "1.269" "1.155" "1.217" "1.162" "1.206" "1.294" "1.210" "1.134" "1.158" "247.5" "314.1" "286.0" "301.3" "287.7" "298.4" "320.3" "299.4" "280.6" "286.6" "" "" "" "" "" "" "" "" "" "" "247.5" "265.8" "180.8" "219.7" "235.7" "231.7" "246.9" "257.4" "219.0" "257.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "19.750" "9" "6" "6" "4" "772" "87.6" "8.41" "19.80" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "miRNA regulation of DNA damage response; DNA damage response" "" "2" "1" "1.002" "0.820" "1.022" "1.087" "0.933" "1.056" "0.962" "0.786" "0.951" "257.7" "258.2" "211.4" "263.5" "280.2" "240.5" "272.2" "247.9" "202.6" "245.1" "" "" "" "" "" "" "" "" "" "" "257.7" "218.5" "133.7" "192.1" "229.5" "186.8" "209.8" "213.1" "158.2" "220.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "19.738" "10" "3" "8" "3" "335" "36.4" "6.35" "28.49" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.031" "1.124" "1.065" "1.100" "1.063" "0.982" "1.023" "1.069" "1.042" "515.9" "531.9" "580.1" "549.2" "567.5" "548.5" "506.4" "527.8" "551.6" "537.4" "" "" "" "" "" "" "" "" "" "" "515.9" "450.0" "366.8" "400.5" "465.0" "425.9" "390.3" "453.8" "430.6" "483.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6367954742648610470" "False" "High" "IsMasterProtein" "Cont_E1BJK2" "Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB1 PE=3 SV=1" "0.000" "True" "19.732" "6" "3" "11" "1" "450" "50.0" "5.11" "27.51" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "541271" "ENSBIXG00000020524; ENSBTAG00000018785" "TUBB1" "A0A4W2CSS1; bta:541271; E1BJK2" "Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway" "" "2" "0" "0.985" "0.762" "0.940" "0.892" "0.680" "0.628" "0.953" "0.898" "0.591" "26.5" "26.1" "20.2" "24.9" "23.7" "18.0" "16.7" "25.3" "23.8" "15.7" "" "" "" "" "" "" "" "" "" "" "26.5" "22.1" "12.8" "18.2" "19.4" "14.0" "12.8" "21.7" "18.6" "14.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "19.731" "13" "4" "5" "4" "382" "42.4" "5.36" "20.58" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "TGF-beta signaling pathway; MAPK signaling pathway" "Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "4" "0" "1.067" "1.078" "1.075" "0.949" "1.093" "0.971" "1.029" "1.070" "1.042" "259.8" "277.2" "280.1" "279.3" "246.6" "284.1" "252.3" "267.4" "278.1" "270.7" "" "" "" "" "" "" "" "" "" "" "259.8" "234.5" "177.1" "203.7" "202.1" "220.6" "194.5" "229.9" "217.0" "243.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "19.727" "9" "6" "6" "6" "651" "72.8" "7.44" "18.17" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.023" "0.865" "1.059" "1.106" "0.921" "1.121" "1.124" "0.927" "1.068" "251.9" "257.9" "218.0" "266.8" "278.6" "232.1" "282.5" "283.2" "233.5" "269.2" "" "" "" "" "" "" "" "" "" "" "251.9" "218.1" "137.9" "194.6" "228.2" "180.3" "217.7" "243.5" "182.3" "242.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1951462620907489343" "False" "High" "IsMasterProtein" "O75326" "Semaphorin-7A OS=Homo sapiens OX=9606 GN=SEMA7A PE=1 SV=1" "0.000" "False" "19.720" "10" "6" "7" "6" "666" "74.8" "7.64" "17.48" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf01403, Pf01437, Pf13895" "8482" "ENSG00000138623; ENSG00000288455" "SEMA7A" "B4DDP7; F5H1S0; hsa:8482; O75326; Q1XE81; Q1XE82; Q1XE83; Q1XE84; Q3MIY5" "" "Other semaphorin interactions" "1" "0" "1.046" "1.031" "1.006" "1.034" "1.052" "0.961" "1.001" "1.097" "1.064" "325.4" "340.5" "335.4" "327.2" "336.3" "342.1" "312.6" "325.6" "357.0" "346.1" "" "" "" "" "" "" "" "" "" "" "325.4" "288.0" "212.1" "238.6" "275.5" "265.7" "241.0" "279.9" "278.7" "311.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "19.709" "6" "4" "4" "4" "736" "82.8" "7.31" "14.87" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "1.195" "1.447" "1.277" "1.174" "1.450" "1.222" "1.191" "1.430" "1.120" "230.3" "275.2" "333.1" "294.2" "270.4" "333.8" "281.4" "274.3" "329.3" "257.9" "" "" "" "" "" "" "" "" "" "" "230.3" "232.8" "210.6" "214.5" "221.6" "259.2" "216.9" "235.8" "257.1" "231.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "19.676" "20" "6" "9" "6" "249" "28.4" "9.23" "29.50" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Eukaryotic transcription initiation" "TP53 Regulates Transcription of DNA Repair Genes; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "33" "0" "0.987" "0.970" "0.988" "0.974" "0.910" "1.026" "0.925" "0.959" "0.992" "265.6" "262.1" "257.5" "262.5" "258.8" "241.6" "272.5" "245.7" "254.8" "263.5" "" "" "" "" "" "" "" "" "" "" "265.6" "221.7" "162.8" "191.4" "212.0" "187.6" "210.1" "211.3" "198.9" "236.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "19.662" "17" "2" "7" "2" "173" "18.9" "4.88" "25.00" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "" "Glycine degradation" "2" "0" "0.951" "1.221" "0.928" "1.044" "1.125" "1.113" "1.002" "0.982" "1.055" "590.9" "562.1" "721.8" "548.2" "617.0" "664.8" "658.0" "592.3" "580.2" "623.7" "" "" "" "" "" "" "" "" "" "" "590.9" "475.5" "456.4" "399.7" "505.5" "516.3" "507.2" "509.3" "452.9" "560.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "19.633" "12" "4" "6" "4" "360" "39.8" "6.61" "21.45" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.125" "1.184" "0.982" "1.001" "1.219" "1.103" "0.993" "1.092" "1.240" "142.0" "159.7" "168.1" "139.4" "142.2" "173.0" "156.6" "140.9" "155.1" "176.1" "" "" "" "" "" "" "" "" "" "" "142.0" "135.1" "106.3" "101.7" "116.5" "134.4" "120.7" "121.2" "121.1" "158.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.000" "False" "19.632" "20" "5" "5" "5" "280" "32.2" "7.80" "18.36" "5" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "B cell receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "2" "0" "0.969" "0.747" "0.871" "0.964" "0.775" "0.934" "0.892" "0.766" "0.800" "206.6" "200.2" "154.3" "179.8" "199.1" "160.0" "193.0" "184.2" "158.2" "165.2" "" "" "" "" "" "" "" "" "" "" "206.6" "169.3" "97.6" "131.1" "163.1" "124.3" "148.7" "158.4" "123.5" "148.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "19.624" "14" "4" "4" "4" "334" "36.6" "8.27" "15.38" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Pleural mesothelioma; Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RMTs methylate histone arginines; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "10" "0" "0.953" "0.818" "0.941" "1.008" "0.851" "1.004" "1.013" "0.930" "1.027" "365.4" "348.2" "299.1" "343.8" "368.2" "311.1" "367.0" "370.0" "340.0" "375.4" "" "" "" "" "" "" "" "" "" "" "365.4" "294.6" "189.1" "250.7" "301.7" "241.6" "282.9" "318.1" "265.4" "337.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "19.622" "9" "3" "4" "3" "360" "41.3" "7.90" "15.11" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.103" "0.964" "1.006" "1.095" "1.079" "1.032" "1.041" "1.013" "1.004" "131.6" "145.2" "126.9" "132.4" "144.2" "142.1" "135.9" "137.0" "133.3" "132.1" "" "" "" "" "" "" "" "" "" "" "131.6" "122.8" "80.2" "96.5" "118.1" "110.3" "104.8" "117.8" "104.1" "118.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8328010223539768625" "False" "High" "IsMasterProtein" "P0DMU7" "Cancer/testis antigen family 45 member A6 OS=Homo sapiens OX=9606 GN=CT45A6 PE=2 SV=1" "0.000" "False" "19.610" "25" "5" "8" "1" "189" "21.2" "9.69" "26.30" "5" "" "" "" "Pf15300" "101060211; 441521; 541465" "ENSG00000278289" "CT45A6" "hsa:101060211; hsa:441521; hsa:541465; P0DMU7; Q8N7B7" "" "" "0" "3" "0.998" "1.181" "0.872" "1.122" "1.235" "1.142" "1.058" "1.077" "1.069" "470.2" "469.1" "555.1" "409.9" "527.4" "580.9" "537.0" "497.3" "506.3" "502.7" "" "" "" "" "" "" "" "" "" "" "470.2" "396.9" "351.0" "298.9" "432.1" "451.1" "413.9" "427.6" "395.2" "451.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "19.592" "8" "5" "5" "5" "591" "64.4" "8.76" "17.50" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "5" "0" "0.987" "0.829" "0.928" "1.026" "0.935" "1.022" "1.061" "0.806" "0.841" "318.3" "314.0" "264.0" "295.3" "326.4" "297.5" "325.4" "337.7" "256.6" "267.8" "" "" "" "" "" "" "" "" "" "" "318.3" "265.7" "166.9" "215.4" "267.4" "231.1" "250.8" "290.4" "200.3" "240.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "19.585" "25" "4" "4" "3" "185" "21.4" "4.93" "15.09" "4" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "Effect of progerin on genes involved in progeria" "HCMV Early Events" "2" "0" "1.098" "1.110" "1.089" "1.173" "1.391" "1.406" "1.077" "1.317" "1.168" "50.7" "55.7" "56.3" "55.2" "59.5" "70.5" "71.3" "54.6" "66.8" "59.2" "" "" "" "" "" "" "" "" "" "" "50.7" "47.1" "35.6" "40.3" "48.7" "54.8" "55.0" "47.0" "52.1" "53.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5139154873677700372" "False" "High" "IsMasterProtein" "Q9H9V9" "2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Homo sapiens OX=9606 GN=JMJD4 PE=1 SV=3" "0.000" "False" "19.581" "13" "4" "4" "4" "417" "47.4" "5.54" "16.20" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "65094" "ENSG00000081692" "JMJD4" "A0A087WT84; hsa:65094; Q5TBZ1; Q5TBZ6; Q9H970; Q9H9V9" "" "Protein hydroxylation" "1" "0" "0.973" "0.895" "0.965" "0.947" "0.948" "0.936" "0.948" "0.909" "0.942" "240.1" "233.5" "214.9" "231.6" "227.2" "227.5" "224.6" "227.6" "218.2" "226.2" "" "" "" "" "" "" "" "" "" "" "240.1" "197.6" "135.9" "168.9" "186.2" "176.7" "173.1" "195.7" "170.3" "203.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.000" "False" "19.581" "14" "5" "5" "5" "419" "47.2" "8.94" "15.96" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "9" "0" "1.102" "1.241" "1.077" "1.124" "1.285" "1.076" "1.043" "1.183" "1.134" "187.7" "206.7" "232.9" "202.1" "210.9" "241.1" "201.9" "195.7" "222.0" "212.7" "" "" "" "" "" "" "" "" "" "" "187.7" "174.9" "147.2" "147.4" "172.8" "187.3" "155.7" "168.3" "173.3" "191.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "19.578" "13" "5" "6" "5" "454" "50.1" "8.25" "19.84" "5" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.064" "0.960" "1.011" "1.029" "0.982" "1.034" "0.998" "0.955" "0.985" "328.4" "349.5" "315.3" "332.1" "338.1" "322.4" "339.6" "327.6" "313.6" "323.5" "" "" "" "" "" "" "" "" "" "" "328.4" "295.6" "199.4" "242.2" "277.0" "250.3" "261.8" "281.7" "244.8" "290.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3534429540462627294" "False" "High" "IsMasterProtein" "P09525" "Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4" "0.000" "False" "19.574" "18" "6" "10" "5" "319" "35.9" "6.13" "30.39" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "307" "ENSG00000196975" "ANXA4" "B4DDF9; hsa:307; P09525; Q6LES2; Q96F33; Q9BWK1" "Prostaglandin synthesis and regulation" "" "1" "0" "1.286" "1.140" "1.287" "1.506" "1.075" "1.110" "1.363" "1.274" "1.599" "42.4" "54.5" "48.3" "54.6" "63.9" "45.6" "47.1" "57.8" "54.0" "67.8" "" "" "" "" "" "" "" "" "" "" "42.4" "46.1" "30.6" "39.8" "52.3" "35.4" "36.3" "49.7" "42.2" "61.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "19.545" "22" "4" "6" "4" "244" "25.8" "7.37" "20.66" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "" "Phenylalanine metabolism" "1" "0" "1.007" "1.137" "1.040" "1.037" "1.146" "1.100" "1.017" "1.180" "1.121" "180.9" "182.2" "205.7" "188.2" "187.7" "207.3" "199.1" "183.9" "213.5" "202.8" "" "" "" "" "" "" "" "" "" "" "180.9" "154.1" "130.1" "137.3" "153.8" "161.0" "153.4" "158.1" "166.6" "182.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "19.540" "52" "3" "7" "3" "96" "10.4" "4.48" "28.64" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "" "mRNA Splicing - Major Pathway" "1" "0" "0.941" "1.043" "0.978" "1.018" "1.086" "1.109" "0.973" "1.188" "0.990" "246.5" "231.8" "257.1" "241.1" "250.8" "267.6" "273.2" "239.9" "292.8" "244.0" "" "" "" "" "" "" "" "" "" "" "246.5" "196.1" "162.6" "175.8" "205.5" "207.8" "210.6" "206.2" "228.6" "219.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7838191573175713795" "False" "High" "IsMasterProtein" "Q9Y4B5" "Microtubule cross-linking factor 1 OS=Homo sapiens OX=9606 GN=MTCL1 PE=1 SV=5" "0.000" "False" "19.513" "3" "6" "7" "6" "1905" "209.4" "6.43" "22.37" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf11365, Pf14818" "23255" "ENSG00000168502" "MTCL1" "E9PAY7; hsa:23255; Q6ZMQ9; Q8IWA9; Q9Y4B5" "" "" "0" "0" "1.015" "1.083" "1.070" "0.996" "1.022" "1.110" "1.067" "0.849" "1.058" "260.8" "264.8" "282.5" "279.1" "259.8" "266.4" "289.5" "278.3" "221.3" "275.9" "" "" "" "" "" "" "" "" "" "" "260.8" "224.0" "178.6" "203.5" "212.9" "206.9" "223.1" "239.3" "172.8" "248.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "19.508" "16" "4" "6" "4" "285" "31.6" "5.31" "19.30" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.041" "1.043" "0.988" "1.162" "1.230" "1.008" "1.099" "1.130" "1.217" "258.6" "269.1" "269.6" "255.6" "300.6" "318.0" "260.7" "284.2" "292.2" "314.7" "" "" "" "" "" "" "" "" "" "" "258.6" "227.7" "170.5" "186.3" "246.2" "246.9" "201.0" "244.4" "228.1" "282.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "19.505" "23" "3" "6" "3" "177" "20.2" "4.81" "24.76" "3" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.963" "1.000" "0.979" "0.988" "0.988" "0.919" "0.876" "0.913" "1.047" "341.7" "329.0" "341.7" "334.4" "337.7" "337.6" "314.1" "299.4" "312.0" "357.9" "" "" "" "" "" "" "" "" "" "" "341.7" "278.3" "216.1" "243.8" "276.7" "262.2" "242.1" "257.4" "243.5" "321.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1753263337049179801" "False" "High" "IsMasterProtein" "O75808" "Calpain-15 OS=Homo sapiens OX=9606 GN=CAPN15 PE=1 SV=1" "0.000" "False" "19.481" "5" "4" "4" "4" "1086" "117.2" "6.71" "14.29" "4" "protein metabolism" "other cell component" "other molecular function" "Pf00641, Pf00648" "6650" "ENSG00000103326" "CAPN15" "B1B1M4; hsa:6650; O75808; Q2KHS2; Q8WTY9; Q9BUW0" "" "Degradation of the extracellular matrix" "1" "0" "1.027" "0.969" "1.042" "1.036" "0.974" "1.037" "1.067" "0.917" "1.061" "171.5" "176.1" "166.3" "178.7" "177.8" "167.1" "177.8" "183.0" "157.3" "182.0" "" "" "" "" "" "" "" "" "" "" "171.5" "149.0" "105.1" "130.3" "145.6" "129.7" "137.1" "157.4" "122.8" "163.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "High" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.000" "False" "19.450" "3" "5" "6" "5" "1860" "206.4" "5.73" "20.15" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "4" "0" "1.084" "0.882" "1.252" "1.136" "0.854" "1.153" "1.152" "0.887" "1.077" "126.9" "137.5" "111.9" "158.8" "144.2" "108.3" "146.3" "146.2" "112.5" "136.6" "" "" "" "" "" "" "" "" "" "" "126.9" "116.4" "70.8" "115.8" "118.1" "84.1" "112.7" "125.7" "87.8" "122.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "19.397" "16" "5" "8" "5" "297" "33.2" "6.60" "26.21" "5" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Trans-sulfuration pathway; Amino acid metabolism" "Degradation of cysteine and homocysteine" "3" "0" "1.207" "0.927" "1.066" "1.074" "0.936" "1.069" "1.072" "0.952" "1.053" "299.4" "361.3" "277.5" "319.2" "321.5" "280.1" "320.0" "320.8" "285.0" "315.4" "" "" "" "" "" "" "" "" "" "" "299.4" "305.7" "175.5" "232.7" "263.4" "217.6" "246.7" "275.9" "222.5" "283.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7134099629064500407" "False" "High" "IsMasterProtein" "Q9P2Q2" "FERM domain-containing protein 4A OS=Homo sapiens OX=9606 GN=FRMD4A PE=1 SV=3" "0.000" "False" "19.366" "6" "5" "6" "5" "1039" "115.4" "8.87" "18.56" "5" "other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00373, Pf09379, Pf09380, Pf11819" "55691" "ENSG00000151474" "FRMD4A" "A7E2Y3; hsa:55691; Q5T377; Q9P2Q2" "" "" "0" "0" "1.032" "0.865" "1.159" "1.026" "0.938" "1.068" "1.023" "0.938" "0.975" "268.7" "277.2" "232.5" "311.5" "275.7" "252.0" "287.1" "274.8" "252.1" "261.9" "" "" "" "" "" "" "" "" "" "" "268.7" "234.5" "147.0" "227.1" "225.9" "195.7" "221.3" "236.2" "196.8" "235.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "19.347" "10" "5" "5" "5" "495" "56.2" "7.58" "17.16" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "3" "0" "1.095" "0.760" "1.132" "1.162" "0.881" "1.114" "0.973" "0.882" "0.991" "214.2" "234.5" "162.7" "242.4" "248.9" "188.7" "238.6" "208.4" "188.8" "212.2" "" "" "" "" "" "" "" "" "" "" "214.2" "198.4" "102.9" "176.7" "203.9" "146.5" "183.9" "179.2" "147.4" "190.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "19.323" "15" "3" "7" "3" "201" "23.4" "6.64" "20.74" "3" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Pyrimidine metabolism" "Purine catabolism; Pyrimidine catabolism" "3" "0" "0.895" "1.152" "0.926" "1.045" "1.113" "0.964" "0.996" "1.098" "1.071" "294.5" "263.7" "339.2" "272.8" "307.9" "327.9" "283.9" "293.4" "323.4" "315.3" "" "" "" "" "" "" "" "" "" "" "294.5" "223.1" "214.5" "198.9" "252.3" "254.7" "218.8" "252.2" "252.5" "283.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "19.289" "14" "5" "6" "5" "338" "38.7" "7.65" "17.92" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.010" "0.972" "0.959" "1.078" "1.114" "1.077" "1.044" "1.028" "0.993" "310.8" "314.0" "302.2" "298.1" "334.9" "346.2" "334.7" "324.4" "319.5" "308.5" "" "" "" "" "" "" "" "" "" "" "310.8" "265.6" "191.1" "217.4" "274.4" "268.9" "258.0" "278.9" "249.4" "277.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "19.282" "18" "3" "14" "3" "146" "17.2" "6.11" "42.13" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "1.073" "1.193" "0.984" "1.003" "1.366" "0.982" "1.121" "1.137" "1.181" "600.2" "644.2" "716.1" "590.6" "601.9" "820.2" "589.4" "672.7" "682.3" "709.1" "" "" "" "" "" "" "" "" "" "" "600.2" "545.0" "452.8" "430.6" "493.2" "636.9" "454.3" "578.4" "532.6" "637.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3168317114658066086" "False" "High" "IsMasterProtein" "Q9UH03" "Neuronal-specific septin-3 OS=Homo sapiens OX=9606 GN=SEPTIN3 PE=1 SV=3" "0.000" "False" "19.275" "16" "6" "8" "6" "358" "40.7" "7.20" "23.23" "6" "cell cycle OR cell proliferation" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55964" "ENSG00000100167" "SEPTIN3" "B1AHR0; hsa:55964; Q2NKJ7; Q59GF7; Q6IBZ6; Q8N3P3; Q9HD35; Q9UH03" "" "" "0" "0" "0.980" "1.071" "1.018" "1.017" "1.034" "0.986" "0.972" "1.029" "0.949" "706.1" "691.9" "756.2" "718.6" "718.0" "730.0" "696.5" "686.2" "726.3" "669.8" "" "" "" "" "" "" "" "" "" "" "706.1" "585.3" "478.2" "524.0" "588.3" "566.9" "536.9" "590.0" "566.9" "602.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "19.270" "8" "5" "5" "5" "708" "77.1" "9.10" "17.96" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "0.743" "0.661" "0.954" "0.860" "0.899" "0.929" "0.972" "0.980" "0.670" "27.7" "20.6" "18.3" "26.4" "23.8" "24.9" "25.7" "26.9" "27.2" "18.6" "" "" "" "" "" "" "" "" "" "" "27.7" "17.4" "11.6" "19.3" "19.5" "19.3" "19.8" "23.2" "21.2" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "19.258" "16" "5" "6" "5" "314" "35.5" "6.20" "17.89" "5" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "" "Neutrophil degranulation" "1" "0" "0.951" "1.052" "1.018" "0.997" "1.086" "1.083" "0.985" "1.161" "0.883" "271.1" "257.9" "285.2" "275.9" "270.4" "294.3" "293.7" "267.0" "314.7" "239.4" "" "" "" "" "" "" "" "" "" "" "271.1" "218.2" "180.3" "201.2" "221.5" "228.5" "226.4" "229.6" "245.7" "215.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.000" "False" "19.251" "15" "6" "7" "6" "399" "46.0" "8.53" "17.95" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "1.186" "0.995" "1.082" "0.965" "0.892" "0.892" "0.973" "1.200" "1.106" "271.1" "321.5" "269.6" "293.3" "261.5" "241.9" "241.8" "263.6" "325.4" "299.7" "" "" "" "" "" "" "" "" "" "" "271.1" "272.0" "170.5" "213.9" "214.2" "187.9" "186.4" "226.7" "254.0" "269.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "19.242" "13" "4" "4" "4" "325" "36.5" "5.64" "15.79" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.917" "0.964" "0.901" "0.997" "0.961" "0.943" "1.033" "0.849" "0.935" "364.8" "334.4" "351.7" "328.8" "363.7" "350.5" "344.1" "376.8" "309.8" "341.3" "" "" "" "" "" "" "" "" "" "" "364.8" "282.9" "222.4" "239.7" "298.0" "272.2" "265.2" "324.0" "241.8" "306.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4691271095298353856" "False" "High" "IsMasterProtein" "Q13114" "TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2" "0.000" "False" "19.241" "10" "6" "6" "5" "568" "64.4" "7.91" "17.52" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7187" "ENSG00000131323" "TRAF3" "B7Z8C4; hsa:7187; Q12990; Q13076; Q13114; Q13947; Q6AZX1; Q9UNL1" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; miRNA role in immune response in sepsis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Type I interferon induction and signaling during SARS-CoV-2 infection; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 2q37 copy number variation syndrome; 13q12.12 copy number variation; Toll-like receptor signaling pathway" "Ovarian tumor domain proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Negative regulators of DDX58/IFIH1 signaling; TRAF3 deficiency - HSE; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway" "35" "0" "1.046" "0.851" "1.108" "1.015" "0.962" "0.960" "1.041" "1.019" "1.005" "499.4" "522.2" "424.8" "553.4" "506.8" "480.5" "479.6" "519.7" "509.1" "502.1" "" "" "" "" "" "" "" "" "" "" "499.4" "441.8" "268.6" "403.5" "415.2" "373.2" "369.7" "446.8" "397.4" "451.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "19.235" "7" "5" "5" "5" "856" "96.7" "6.54" "17.81" "5" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.244" "0.992" "1.238" "1.151" "0.972" "0.902" "1.145" "0.879" "0.994" "83.2" "103.5" "82.5" "103.0" "95.8" "80.9" "75.1" "95.3" "73.2" "82.7" "" "" "" "" "" "" "" "" "" "" "83.2" "87.6" "52.2" "75.1" "78.5" "62.8" "57.9" "81.9" "57.1" "74.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032726270839277036" "False" "High" "IsMasterProtein" "P27144" "Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1" "0.000" "False" "19.227" "23" "5" "5" "5" "223" "25.3" "8.40" "15.20" "5" "other metabolic processes;stress response;other biological processes" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "205" "ENSG00000162433" "AK4" "B2R927; D3DQ62; hsa:205; P27144; Q6IBH4; Q6NXQ5; Q8IUU9" "CCL18 signaling pathway" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.861" "0.928" "0.920" "0.930" "0.918" "0.951" "0.933" "0.899" "0.888" "462.9" "398.7" "429.7" "425.9" "430.4" "425.0" "440.4" "432.0" "415.9" "411.0" "" "" "" "" "" "" "" "" "" "" "462.9" "337.3" "271.7" "310.6" "352.6" "330.1" "339.5" "371.4" "324.7" "369.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "538564902379484332" "False" "High" "IsMasterProtein" "P49815" "Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2" "0.000" "False" "19.213" "3" "5" "5" "5" "1807" "200.5" "7.31" "16.06" "5" "stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf03542, Pf11864" "7249" "ENSG00000103197" "TSC2" "A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378; hsa:7249; O75275; P49815; Q4LE71; Q8TAZ1" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; ATM signaling in development and disease ; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; p53 transcriptional gene network; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Monoamine transport" "Macroautophagy; Constitutive Signaling by AKT1 E17K in Cancer; TP53 Regulates Metabolic Genes; AKT phosphorylates targets in the cytosol; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "35" "0" "1.007" "0.888" "1.021" "1.075" "0.825" "1.134" "1.077" "0.779" "0.938" "72.7" "73.2" "64.6" "74.3" "78.2" "60.0" "82.5" "78.4" "56.7" "68.2" "" "" "" "" "" "" "" "" "" "" "72.7" "61.9" "40.8" "54.1" "64.0" "46.6" "63.6" "67.4" "44.2" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735659524784303490" "False" "High" "IsMasterProtein" "Q8IV50" "LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LYSMD2 PE=1 SV=1" "0.000" "False" "19.207" "20" "4" "7" "4" "215" "23.4" "5.35" "19.78" "4" "" "" "" "Pf01476" "256586" "ENSG00000140280" "LYSMD2" "hsa:256586; Q5CZ88; Q8IV50; Q8WTV3" "" "" "0" "0" "0.995" "1.010" "1.093" "0.972" "1.029" "1.061" "1.065" "0.917" "1.094" "280.2" "278.7" "282.9" "306.4" "272.2" "288.2" "297.4" "298.3" "256.9" "306.6" "" "" "" "" "" "" "" "" "" "" "280.2" "235.8" "178.9" "223.4" "223.1" "223.8" "229.2" "256.5" "200.5" "275.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "19.199" "21" "3" "9" "3" "161" "18.1" "6.79" "23.60" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.043" "1.036" "1.129" "1.091" "0.974" "1.139" "1.009" "1.090" "1.142" "270.6" "282.3" "280.3" "305.6" "295.2" "263.6" "308.3" "273.0" "294.9" "308.9" "" "" "" "" "" "" "" "" "" "" "270.6" "238.8" "177.2" "222.8" "241.8" "204.7" "237.6" "234.7" "230.2" "277.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "19.186" "19" "6" "7" "6" "314" "35.8" "8.50" "19.01" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "1.081" "0.903" "0.939" "1.027" "1.078" "0.934" "0.933" "1.062" "1.063" "249.6" "269.8" "225.4" "234.3" "256.3" "269.1" "233.0" "232.9" "264.9" "265.3" "" "" "" "" "" "" "" "" "" "" "249.6" "228.3" "142.5" "170.8" "210.0" "209.0" "179.6" "200.2" "206.8" "238.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "19.184" "15" "2" "3" "2" "164" "17.8" "5.03" "13.18" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "0.981" "0.872" "1.051" "1.054" "0.913" "1.050" "1.110" "0.913" "0.908" "223.7" "219.5" "195.1" "235.2" "235.7" "204.3" "234.9" "248.3" "204.2" "203.0" "" "" "" "" "" "" "" "" "" "" "223.7" "185.7" "123.4" "171.5" "193.1" "158.6" "181.1" "213.5" "159.4" "182.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "19.182" "11" "5" "8" "5" "414" "44.7" "6.19" "24.26" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "" "2" "0" "0.949" "0.734" "0.902" "0.925" "0.733" "0.881" "1.046" "0.696" "0.692" "890.6" "844.9" "654.1" "803.6" "823.6" "653.0" "784.7" "931.5" "619.5" "616.7" "" "" "" "" "" "" "" "" "" "" "890.6" "714.8" "413.6" "585.9" "674.8" "507.1" "604.8" "800.9" "483.5" "554.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "19.161" "10" "4" "4" "4" "517" "59.1" "5.97" "15.23" "4" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "0" "1.055" "0.975" "1.169" "1.004" "1.141" "1.057" "0.964" "1.092" "0.893" "121.5" "128.1" "118.4" "142.0" "122.0" "138.5" "128.4" "117.1" "132.6" "108.5" "" "" "" "" "" "" "" "" "" "" "121.5" "108.4" "74.8" "103.5" "99.9" "107.6" "99.0" "100.7" "103.5" "97.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904106809310251565" "False" "High" "IsMasterProtein" "Q9Y6X9" "ATPase MORC2 OS=Homo sapiens OX=9606 GN=MORC2 PE=1 SV=2" "0.000" "False" "19.159" "6" "6" "7" "6" "1032" "117.8" "8.38" "21.26" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07496, Pf13589, Pf17942" "22880" "ENSG00000133422" "MORC2" "B2RNB1; hsa:22880; Q9UF28; Q9Y6V2; Q9Y6X9" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.106" "1.039" "1.043" "0.989" "1.031" "1.084" "0.886" "0.996" "1.069" "129.8" "143.6" "134.9" "135.4" "128.4" "133.9" "140.7" "115.0" "129.4" "138.8" "" "" "" "" "" "" "" "" "" "" "129.8" "121.5" "85.3" "98.7" "105.2" "104.0" "108.5" "98.9" "101.0" "124.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "19.140" "15" "4" "5" "4" "290" "31.4" "8.07" "15.22" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "10" "0" "1.216" "1.087" "1.218" "1.034" "1.060" "1.169" "0.992" "1.208" "1.156" "259.7" "315.9" "282.4" "316.4" "268.6" "275.2" "303.6" "257.7" "313.8" "300.1" "" "" "" "" "" "" "" "" "" "" "259.7" "267.2" "178.6" "230.7" "220.1" "213.7" "234.1" "221.6" "244.9" "269.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322674044200343444" "False" "High" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "0.000" "False" "19.131" "3" "6" "6" "6" "2109" "238.7" "7.30" "21.58" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.930" "0.739" "1.116" "0.985" "0.894" "1.092" "0.977" "0.896" "1.017" "149.4" "138.9" "110.4" "166.7" "147.2" "133.5" "163.1" "146.0" "133.9" "151.8" "" "" "" "" "" "" "" "" "" "" "149.4" "117.5" "69.8" "121.5" "120.6" "103.7" "125.7" "125.5" "104.5" "136.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "19.110" "19" "6" "9" "6" "318" "36.8" "6.46" "23.25" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "0.890" "1.100" "0.916" "0.900" "0.948" "0.881" "0.980" "0.973" "0.975" "655.2" "583.3" "720.9" "600.1" "589.4" "620.8" "577.3" "641.8" "637.6" "638.5" "" "" "" "" "" "" "" "" "" "" "655.2" "493.5" "455.8" "437.5" "482.9" "482.1" "445.0" "551.8" "497.6" "574.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "19.103" "14" "4" "6" "3" "284" "33.3" "9.31" "21.15" "4" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "1" "1.008" "1.245" "0.965" "0.963" "1.099" "0.886" "1.112" "1.146" "1.126" "360.1" "362.8" "448.3" "347.6" "346.9" "395.7" "319.2" "400.4" "412.7" "405.6" "" "" "" "" "" "" "" "" "" "" "360.1" "307.0" "283.5" "253.4" "284.2" "307.3" "246.1" "344.2" "322.2" "364.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5016840321552797541" "False" "High" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "0.000" "False" "19.103" "7" "7" "7" "6" "924" "104.0" "6.90" "19.42" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "7" "0" "0.981" "0.877" "1.069" "1.063" "0.863" "0.984" "0.948" "0.876" "0.994" "139.0" "136.3" "121.9" "148.7" "147.7" "120.0" "136.8" "131.8" "121.8" "138.2" "" "" "" "" "" "" "" "" "" "" "139.0" "115.4" "77.1" "108.4" "121.0" "93.2" "105.4" "113.4" "95.1" "124.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "19.100" "28" "3" "7" "3" "118" "12.9" "5.52" "23.24" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "1.001" "1.015" "0.992" "0.974" "1.052" "1.045" "0.974" "0.993" "1.104" "465.8" "466.3" "472.6" "462.1" "453.9" "490.1" "486.8" "453.8" "462.7" "514.3" "" "" "" "" "" "" "" "" "" "" "465.8" "394.5" "298.8" "336.9" "371.9" "380.6" "375.3" "390.2" "361.2" "462.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "19.091" "12" "7" "8" "6" "530" "60.1" "9.13" "24.20" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "MECP2 and associated Rett syndrome" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "8" "0" "1.075" "0.878" "0.970" "1.090" "0.981" "0.931" "0.964" "0.913" "0.980" "485.1" "521.6" "425.9" "470.7" "528.5" "476.0" "451.6" "467.8" "442.8" "475.5" "" "" "" "" "" "" "" "" "" "" "485.1" "441.3" "269.3" "343.2" "433.0" "369.6" "348.1" "402.3" "345.6" "427.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236984144033134213" "False" "High" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "0.000" "False" "19.083" "5" "6" "6" "6" "894" "101.9" "6.61" "17.81" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277, Pf20654" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.351" "0.784" "1.123" "1.141" "1.027" "0.961" "1.083" "1.033" "1.074" "128.9" "174.1" "101.1" "144.8" "147.0" "132.5" "123.8" "139.6" "133.1" "138.4" "" "" "" "" "" "" "" "" "" "" "128.9" "147.3" "63.9" "105.6" "120.5" "102.9" "95.5" "120.0" "103.9" "124.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.000" "False" "19.060" "8" "4" "6" "4" "508" "56.9" "7.09" "18.62" "4" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "1.081" "0.892" "1.159" "1.056" "0.882" "1.078" "1.067" "0.894" "1.082" "235.5" "254.7" "210.0" "272.9" "248.8" "207.7" "254.0" "251.3" "210.5" "254.9" "" "" "" "" "" "" "" "" "" "" "235.5" "215.4" "132.8" "198.9" "203.8" "161.3" "195.8" "216.1" "164.3" "229.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "19.044" "3" "7" "10" "7" "2644" "301.2" "7.43" "27.16" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "19" "0" "1.004" "0.966" "1.035" "1.040" "0.976" "1.057" "1.103" "0.984" "1.021" "693.5" "696.0" "669.6" "717.6" "721.2" "677.0" "732.8" "764.7" "682.7" "708.1" "" "" "" "" "" "" "" "" "" "" "693.5" "588.8" "423.4" "523.2" "590.9" "525.7" "564.8" "657.5" "532.9" "636.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "19.038" "16" "7" "7" "7" "502" "55.2" "5.62" "18.32" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "" "Nuclear events stimulated by ALK signaling in cancer" "1" "0" "0.989" "0.983" "1.013" "1.084" "0.980" "1.044" "1.050" "0.920" "1.050" "256.7" "253.9" "252.2" "260.1" "278.3" "251.6" "267.9" "269.5" "236.2" "269.5" "" "" "" "" "" "" "" "" "" "" "256.7" "214.8" "159.5" "189.6" "228.0" "195.4" "206.5" "231.7" "184.3" "242.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "19.029" "15" "6" "6" "6" "367" "41.7" "7.25" "17.76" "6" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "Synthesis of PC" "7" "0" "0.984" "0.932" "1.095" "1.100" "0.955" "1.055" "1.101" "0.960" "0.974" "301.6" "296.7" "281.2" "330.4" "331.9" "288.2" "318.1" "332.1" "289.5" "293.9" "" "" "" "" "" "" "" "" "" "" "301.6" "251.1" "177.8" "240.9" "271.9" "223.8" "245.2" "285.6" "226.0" "264.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.000" "False" "19.015" "10" "7" "8" "7" "708" "79.8" "6.47" "24.71" "7" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.072" "0.905" "1.032" "1.019" "0.987" "1.093" "1.110" "0.919" "0.973" "222.4" "238.4" "201.3" "229.6" "226.7" "219.6" "243.1" "247.0" "204.5" "216.5" "" "" "" "" "" "" "" "" "" "" "222.4" "201.7" "127.3" "167.4" "185.7" "170.5" "187.4" "212.3" "159.6" "194.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "19.009" "5" "6" "7" "5" "1313" "140.2" "9.57" "20.55" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "" "2" "0" "1.080" "0.970" "0.996" "0.928" "0.935" "1.146" "1.030" "1.071" "1.000" "105.8" "114.2" "102.6" "105.3" "98.2" "98.9" "121.1" "108.9" "113.3" "105.8" "" "" "" "" "" "" "" "" "" "" "105.8" "96.6" "64.9" "76.8" "80.4" "76.8" "93.4" "93.6" "88.4" "95.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "High" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.000" "False" "18.985" "7" "5" "5" "5" "735" "83.3" "6.79" "17.95" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "1.027" "0.913" "1.036" "1.065" "0.944" "1.089" "1.055" "0.935" "1.010" "302.5" "310.6" "276.4" "313.3" "322.2" "285.7" "329.5" "319.3" "283.0" "305.5" "" "" "" "" "" "" "" "" "" "" "302.5" "262.8" "174.7" "228.5" "264.0" "221.9" "254.0" "274.5" "220.9" "274.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "18.977" "39" "5" "6" "5" "140" "14.9" "10.51" "14.69" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.970" "1.206" "1.057" "1.036" "1.076" "1.039" "1.398" "1.027" "1.228" "47.1" "45.7" "56.8" "49.8" "48.8" "50.7" "48.9" "65.9" "48.4" "57.8" "" "" "" "" "" "" "" "" "" "" "47.1" "38.6" "35.9" "36.3" "40.0" "39.4" "37.7" "56.6" "37.8" "52.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "18.975" "15" "5" "6" "5" "311" "34.0" "6.71" "20.54" "5" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "" "Coenzyme A biosynthesis" "1" "0" "0.880" "1.040" "1.104" "1.103" "1.129" "0.816" "1.029" "1.024" "1.107" "89.5" "78.8" "93.0" "98.8" "98.7" "101.1" "73.0" "92.1" "91.6" "99.0" "" "" "" "" "" "" "" "" "" "" "89.5" "66.6" "58.8" "72.0" "80.9" "78.5" "56.3" "79.2" "71.5" "89.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "18.971" "6" "5" "5" "5" "1120" "125.4" "5.91" "15.69" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6390113821571435192" "False" "High" "IsMasterProtein" "Q9Y2H1" "Serine/threonine-protein kinase 38-like OS=Homo sapiens OX=9606 GN=STK38L PE=1 SV=3" "0.000" "False" "18.948" "13" "6" "7" "6" "464" "54.0" "6.81" "24.95" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00433" "23012" "ENSG00000211455" "STK38L" "A8K4U0; B4E3J8; hsa:23012; Q8TBX7; Q9Y2H1" "Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "" "3" "0" "1.051" "0.816" "1.007" "1.007" "0.791" "0.981" "1.056" "0.797" "0.889" "435.1" "457.4" "355.2" "438.4" "438.2" "344.0" "426.9" "459.4" "346.8" "386.9" "" "" "" "" "" "" "" "" "" "" "435.1" "386.9" "224.6" "319.6" "359.0" "267.2" "329.0" "395.0" "270.7" "347.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "18.936" "8" "5" "5" "5" "833" "91.2" "8.34" "19.15" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "" "14" "0" "0.910" "0.802" "1.010" "0.921" "0.763" "1.087" "0.975" "0.803" "0.938" "279.5" "254.4" "224.0" "282.4" "257.5" "213.4" "303.8" "272.5" "224.5" "262.0" "" "" "" "" "" "" "" "" "" "" "279.5" "215.3" "141.7" "205.9" "210.9" "165.7" "234.2" "234.3" "175.2" "235.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "18.923" "23" "5" "7" "5" "222" "25.6" "8.73" "26.66" "5" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "" "mRNA Splicing - Major Pathway" "1" "0" "0.951" "1.018" "0.934" "0.960" "1.030" "0.919" "0.963" "1.082" "1.049" "235.9" "224.4" "240.0" "220.2" "226.5" "243.0" "216.8" "227.1" "255.3" "247.4" "" "" "" "" "" "" "" "" "" "" "235.9" "189.9" "151.8" "160.6" "185.5" "188.7" "167.1" "195.2" "199.3" "222.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "18.922" "12" "4" "6" "2" "416" "47.3" "7.33" "18.09" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "1" "1.062" "0.948" "0.981" "1.088" "0.996" "1.152" "1.126" "0.997" "0.960" "254.3" "270.2" "241.0" "249.5" "276.7" "253.2" "293.0" "286.4" "253.5" "244.3" "" "" "" "" "" "" "" "" "" "" "254.3" "228.6" "152.4" "182.0" "226.7" "196.6" "225.9" "246.3" "197.8" "219.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "18.920" "11" "5" "6" "5" "543" "60.9" "5.91" "18.21" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "13" "0" "1.043" "0.988" "1.030" "1.038" "0.964" "0.990" "0.971" "0.900" "0.961" "302.6" "315.5" "298.9" "311.7" "314.2" "291.8" "299.4" "293.7" "272.3" "290.8" "" "" "" "" "" "" "" "" "" "" "302.6" "266.9" "189.0" "227.3" "257.4" "226.6" "230.8" "252.5" "212.6" "261.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "18.918" "9" "4" "5" "2" "453" "52.0" "6.39" "16.49" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "MASTL Facilitates Mitotic Progression" "3" "0" "1.147" "1.001" "1.115" "1.094" "1.073" "1.025" "1.128" "1.077" "1.052" "190.0" "218.0" "190.2" "211.8" "207.9" "203.9" "194.7" "214.3" "204.7" "199.8" "" "" "" "" "" "" "" "" "" "" "190.0" "184.4" "120.3" "154.4" "170.3" "158.3" "150.1" "184.3" "159.8" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "18.908" "12" "5" "7" "5" "476" "52.2" "6.15" "21.05" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.993" "0.972" "1.042" "1.096" "1.051" "1.108" "1.006" "1.053" "0.995" "160.5" "159.3" "155.9" "167.3" "175.9" "168.7" "177.9" "161.4" "169.0" "159.6" "" "" "" "" "" "" "" "" "" "" "160.5" "134.8" "98.6" "122.0" "144.1" "131.0" "137.1" "138.8" "131.9" "143.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "18.879" "10" "3" "3" "3" "478" "51.5" "6.83" "9.57" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "" "Pentose phosphate pathway" "1" "0" "0.889" "0.996" "1.148" "0.941" "0.967" "1.237" "1.090" "0.933" "1.038" "37.5" "33.3" "37.3" "43.0" "35.2" "36.2" "46.3" "40.8" "35.0" "38.9" "" "" "" "" "" "" "" "" "" "" "37.5" "28.2" "23.6" "31.4" "28.9" "28.1" "35.7" "35.1" "27.3" "35.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4396257609671438072" "False" "High" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "0.000" "False" "18.861" "4" "2" "4" "2" "1130" "119.6" "4.34" "17.99" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "2" "0" "0.929" "0.617" "0.931" "1.009" "0.875" "1.012" "0.748" "1.040" "0.992" "40.1" "37.2" "24.7" "37.3" "40.4" "35.0" "40.5" "30.0" "41.7" "39.7" "" "" "" "" "" "" "" "" "" "" "40.1" "31.5" "15.6" "27.2" "33.1" "27.2" "31.2" "25.8" "32.5" "35.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "18.845" "24" "5" "7" "5" "180" "20.3" "4.96" "22.21" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.053" "1.042" "1.000" "1.106" "0.996" "1.060" "1.060" "0.977" "1.075" "529.8" "558.0" "552.0" "530.0" "586.1" "527.7" "561.8" "561.4" "517.5" "569.5" "" "" "" "" "" "" "" "" "" "" "529.8" "472.1" "349.0" "386.5" "480.2" "409.8" "433.1" "482.7" "403.9" "512.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "18.829" "7" "5" "5" "4" "801" "88.0" "9.09" "18.06" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "" "RUNX3 regulates p14-ARF" "1" "0" "0.935" "0.865" "1.058" "1.130" "1.224" "0.836" "1.069" "0.973" "0.962" "35.7" "33.3" "30.8" "37.7" "40.3" "43.6" "29.8" "38.1" "34.7" "34.3" "" "" "" "" "" "" "" "" "" "" "35.7" "28.2" "19.5" "27.5" "33.0" "33.9" "23.0" "32.8" "27.1" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "18.827" "10" "3" "9" "3" "277" "29.9" "7.68" "23.81" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; Neutrophil degranulation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Hedgehog 'on' state; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.960" "0.993" "0.975" "0.944" "1.024" "0.921" "0.922" "0.986" "0.990" "727.4" "698.0" "722.5" "708.9" "686.7" "744.5" "669.9" "670.9" "716.9" "719.9" "" "" "" "" "" "" "" "" "" "" "727.4" "590.5" "456.8" "516.9" "562.6" "578.2" "516.4" "576.8" "559.6" "647.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "18.822" "12" "3" "4" "3" "341" "37.6" "8.56" "15.37" "3" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "Signaling by BRAF and RAF1 fusions" "3" "0" "1.066" "0.680" "1.082" "1.155" "0.969" "1.101" "1.179" "0.899" "0.939" "158.4" "168.9" "107.7" "171.4" "182.9" "153.4" "174.3" "186.7" "142.4" "148.7" "" "" "" "" "" "" "" "" "" "" "158.4" "142.9" "68.1" "125.0" "149.8" "119.1" "134.4" "160.5" "111.2" "133.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "18.814" "23" "6" "6" "6" "314" "34.6" "8.24" "19.73" "6" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "0.940" "1.095" "1.017" "1.127" "1.025" "0.856" "1.004" "1.020" "1.010" "133.4" "125.5" "146.1" "135.6" "150.4" "136.8" "114.2" "133.9" "136.1" "134.7" "" "" "" "" "" "" "" "" "" "" "133.4" "106.2" "92.4" "98.9" "123.3" "106.2" "88.0" "115.2" "106.3" "121.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "18.806" "3" "6" "6" "6" "1978" "220.5" "6.38" "16.67" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "" "Transcriptional regulation of white adipocyte differentiation" "1" "0" "1.280" "1.344" "1.348" "1.559" "1.497" "1.586" "1.998" "2.088" "1.238" "13.0" "16.7" "17.5" "17.5" "20.3" "19.5" "20.6" "26.0" "27.2" "16.1" "" "" "" "" "" "" "" "" "" "" "13.0" "14.1" "11.1" "12.8" "16.6" "15.1" "15.9" "22.4" "21.2" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "18.795" "12" "4" "8" "2" "351" "40.7" "4.97" "18.80" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "18.776" "13" "4" "5" "4" "425" "47.8" "5.68" "14.78" "4" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "7" "0" "1.001" "0.913" "1.005" "1.064" "0.968" "1.124" "0.993" "0.906" "0.930" "324.4" "324.6" "296.1" "325.9" "345.1" "314.0" "364.7" "322.1" "293.9" "301.6" "" "" "" "" "" "" "" "" "" "" "324.4" "274.6" "187.2" "237.7" "282.7" "243.9" "281.2" "276.9" "229.4" "271.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "18.770" "13" "3" "5" "3" "460" "50.5" "8.25" "21.75" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "B cell receptor signaling pathway" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "3" "0" "1.219" "1.042" "1.070" "1.168" "1.029" "1.202" "0.862" "1.005" "1.224" "64.3" "78.3" "67.0" "68.8" "75.1" "66.1" "77.2" "55.4" "64.6" "78.6" "" "" "" "" "" "" "" "" "" "" "64.3" "66.3" "42.3" "50.2" "61.5" "51.3" "59.5" "47.6" "50.4" "70.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1044286030628517247" "False" "High" "IsMasterProtein" "P11532" "Dystrophin OS=Homo sapiens OX=9606 GN=DMD PE=1 SV=3" "0.000" "False" "18.765" "1" "5" "5" "5" "3685" "426.5" "5.88" "16.50" "5" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00397, Pf00435, Pf00569, Pf09068, Pf09069" "1756" "ENSG00000198947" "DMD" "A1L0U9; E7EQR9; E7EQS5; E7ESB2; E9PDN1; E9PDN5; F5GZY3; F8VX32; hsa:1756; P11532; Q02295; Q14169; Q14170; Q5JYU0; Q6NSJ9; Q7KZ48; Q8N754; Q9UCW3; Q9UCW4" "Arrhythmogenic right ventricular cardiomyopathy; Ectoderm differentiation; Striated muscle contraction pathway; Acute viral myocarditis; Affected pathways in Duchenne muscular dystrophy; 13q12.12 copy number variation" "Non-integrin membrane-ECM interactions; Striated Muscle Contraction" "8" "0" "0.971" "0.992" "0.896" "1.068" "1.029" "1.042" "1.046" "0.864" "0.928" "315.0" "305.9" "312.5" "282.2" "336.5" "324.3" "328.3" "329.5" "272.2" "292.4" "" "" "" "" "" "" "" "" "" "" "315.0" "258.8" "197.6" "205.8" "275.7" "251.8" "253.1" "283.3" "212.4" "262.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "18.764" "8" "4" "8" "4" "441" "51.1" "5.76" "25.42" "4" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "1.045" "0.980" "0.966" "0.992" "1.097" "1.081" "0.984" "0.958" "1.038" "217.6" "227.3" "213.2" "210.2" "215.9" "238.7" "235.2" "214.1" "208.5" "225.8" "" "" "" "" "" "" "" "" "" "" "217.6" "192.3" "134.8" "153.3" "176.9" "185.4" "181.3" "184.0" "162.7" "203.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.000" "False" "18.761" "5" "6" "6" "6" "1093" "124.8" "6.95" "18.85" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.987" "0.850" "0.962" "0.986" "0.947" "0.974" "1.062" "0.836" "0.974" "320.8" "316.6" "272.7" "308.5" "316.2" "303.9" "312.3" "340.6" "268.0" "312.4" "" "" "" "" "" "" "" "" "" "" "320.8" "267.9" "172.4" "225.0" "259.0" "236.0" "240.7" "292.9" "209.2" "280.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.000" "False" "18.748" "13" "3" "3" "3" "343" "38.9" "4.59" "13.23" "3" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "1.056" "0.857" "1.086" "1.114" "0.982" "1.059" "1.023" "0.909" "1.110" "194.7" "205.7" "166.9" "211.5" "216.9" "191.2" "206.2" "199.2" "177.1" "216.1" "" "" "" "" "" "" "" "" "" "" "194.7" "174.1" "105.6" "154.2" "177.7" "148.5" "158.9" "171.3" "138.2" "194.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.000" "False" "18.747" "6" "6" "6" "6" "936" "102.1" "4.54" "16.16" "6" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "0.967" "0.828" "1.090" "1.074" "0.770" "1.048" "1.090" "0.696" "0.993" "249.1" "240.9" "206.4" "271.5" "267.5" "191.8" "261.1" "271.7" "173.5" "247.4" "" "" "" "" "" "" "" "" "" "" "249.1" "203.8" "130.5" "197.9" "219.2" "149.0" "201.3" "233.6" "135.4" "222.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "High" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.000" "False" "18.727" "16" "3" "3" "3" "341" "37.6" "4.61" "11.54" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "mRNA processing; Ciliary landscape" "" "2" "0" "1.022" "0.985" "1.008" "0.889" "0.879" "0.957" "0.960" "1.042" "1.114" "50.7" "51.7" "49.9" "51.1" "45.0" "44.5" "48.5" "48.7" "52.8" "56.4" "" "" "" "" "" "" "" "" "" "" "50.7" "43.8" "31.5" "37.2" "36.9" "34.6" "37.4" "41.8" "41.2" "50.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "18.723" "14" "6" "6" "6" "442" "49.4" "8.18" "20.96" "6" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "" "Mitochondrial protein degradation; Nicotinate metabolism" "2" "0" "1.143" "1.102" "0.961" "1.002" "1.164" "1.027" "0.964" "1.085" "1.028" "303.3" "346.7" "334.1" "291.5" "304.0" "353.1" "311.6" "292.3" "329.1" "311.7" "" "" "" "" "" "" "" "" "" "" "303.3" "293.3" "211.3" "212.6" "249.1" "274.2" "240.2" "251.4" "256.9" "280.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9066609543119611752" "False" "High" "IsMasterProtein" "Q12851" "Mitogen-activated protein kinase kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP4K2 PE=1 SV=2" "0.000" "False" "18.706" "6" "4" "4" "4" "820" "91.5" "6.34" "14.04" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "5871" "ENSG00000168067" "MAP4K2" "hsa:5871; Q12851; Q86VU3" "TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "" "7" "0" "0.937" "0.920" "0.780" "0.982" "0.921" "0.923" "1.007" "0.879" "0.997" "238.9" "223.8" "219.7" "186.3" "234.5" "220.1" "220.6" "240.7" "210.0" "238.3" "" "" "" "" "" "" "" "" "" "" "238.9" "189.4" "138.9" "135.8" "192.2" "171.0" "170.1" "206.9" "163.9" "214.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "18.687" "27" "3" "4" "3" "125" "14.1" "8.25" "14.53" "3" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial complex IV assembly" "Mitochondrial protein import" "2" "0" "0.973" "0.927" "1.107" "1.049" "0.916" "1.264" "1.087" "0.877" "1.088" "293.8" "286.0" "272.4" "325.2" "308.1" "269.3" "371.5" "319.3" "257.7" "319.8" "" "" "" "" "" "" "" "" "" "" "293.8" "241.9" "172.3" "237.1" "252.5" "209.1" "286.4" "274.5" "201.1" "287.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "18.687" "46" "5" "7" "5" "109" "12.3" "10.24" "23.03" "5" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "Mitochondrial RNA degradation" "1" "0" "0.970" "0.873" "1.009" "0.945" "0.870" "1.019" "0.986" "0.918" "0.959" "739.9" "717.4" "645.7" "746.8" "698.8" "643.4" "753.6" "729.4" "679.1" "709.5" "" "" "" "" "" "" "" "" "" "" "739.9" "607.0" "408.3" "544.5" "572.6" "499.7" "580.9" "627.1" "530.1" "637.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3337700356256422645" "False" "High" "IsMasterProtein" "Q86XR2" "Protein Niban 3 OS=Homo sapiens OX=9606 GN=NIBAN3 PE=1 SV=2" "0.000" "False" "18.685" "8" "6" "8" "6" "697" "77.4" "8.63" "24.72" "6" "" "" "" "" "199786" "ENSG00000167483" "NIBAN3" "B4DNU3; B4DVN7; hsa:199786; Q7Z6H6; Q86XR2; Q86XR3; Q86XR4; Q8TEQ3" "" "" "0" "0" "1.197" "0.853" "1.169" "1.071" "0.832" "1.077" "1.058" "0.825" "0.991" "238.7" "285.7" "203.5" "278.9" "255.5" "198.5" "257.1" "252.6" "196.8" "236.6" "" "" "" "" "" "" "" "" "" "" "238.7" "241.7" "128.7" "203.4" "209.4" "154.1" "198.2" "217.2" "153.6" "212.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "High" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.000" "False" "18.663" "4" "6" "6" "6" "1377" "154.8" "6.34" "18.71" "6" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "1.129" "0.926" "1.126" "1.053" "0.916" "1.104" "1.084" "0.915" "1.058" "321.6" "363.1" "297.7" "362.2" "338.5" "294.6" "355.1" "348.7" "294.1" "340.3" "" "" "" "" "" "" "" "" "" "" "321.6" "307.2" "188.3" "264.1" "277.4" "228.8" "273.7" "299.8" "229.6" "305.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "18.644" "28" "4" "9" "4" "135" "14.7" "5.50" "26.27" "4" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Immune infiltration in pancreatic cancer" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "1.111" "1.199" "1.039" "1.007" "1.177" "1.086" "1.012" "1.301" "1.025" "497.7" "553.0" "596.8" "517.1" "501.0" "585.7" "540.5" "503.7" "647.7" "510.2" "" "" "" "" "" "" "" "" "" "" "497.7" "467.9" "377.4" "377.0" "410.4" "454.9" "416.6" "433.1" "505.5" "458.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1227550599144237947" "False" "High" "IsMasterProtein" "Q6SPF0" "Sterile alpha motif domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1" "0.000" "False" "18.618" "8" "4" "5" "4" "538" "56.0" "7.58" "15.70" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "other molecular function" "Pf00536, Pf21524" "90378" "ENSG00000288488" "SAMD1" "hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4" "" "" "0" "0" "0.841" "0.622" "0.817" "0.919" "0.705" "0.809" "0.859" "0.587" "0.759" "128.6" "108.1" "79.9" "105.0" "118.2" "90.7" "104.0" "110.5" "75.4" "97.6" "" "" "" "" "" "" "" "" "" "" "128.6" "91.5" "50.5" "76.6" "96.8" "70.4" "80.2" "95.0" "58.9" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "18.599" "5" "4" "7" "4" "790" "91.8" "6.43" "23.17" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA processing; 3q29 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "0.999" "1.051" "0.974" "0.964" "0.977" "0.942" "0.990" "0.967" "0.923" "638.6" "638.1" "671.1" "622.2" "615.6" "623.9" "601.4" "632.1" "617.3" "589.4" "" "" "" "" "" "" "" "" "" "" "638.6" "539.8" "424.3" "453.6" "504.3" "484.5" "463.6" "543.5" "481.8" "529.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "18.588" "19" "2" "3" "2" "165" "17.8" "9.42" "14.73" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.059" "1.504" "1.050" "1.268" "1.708" "1.389" "1.284" "1.535" "1.322" "106.4" "112.7" "160.1" "111.8" "135.0" "181.8" "147.9" "136.7" "163.4" "140.8" "" "" "" "" "" "" "" "" "" "" "106.4" "95.4" "101.3" "81.5" "110.6" "141.2" "114.0" "117.5" "127.6" "126.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.000" "False" "18.581" "4" "5" "7" "5" "1234" "138.7" "5.90" "19.48" "5" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "G alpha (q) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; PLC beta mediated events; Acetylcholine regulates insulin secretion" "26" "0" "1.101" "1.109" "1.016" "1.075" "1.162" "1.069" "1.107" "1.154" "1.070" "337.9" "372.2" "374.7" "343.3" "363.3" "392.5" "361.1" "374.2" "389.9" "361.7" "" "" "" "" "" "" "" "" "" "" "337.9" "314.9" "236.9" "250.3" "297.7" "304.8" "278.4" "321.7" "304.4" "325.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "18.574" "12" "5" "6" "5" "443" "51.6" "5.53" "13.48" "5" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "6" "0" "0.935" "1.001" "1.024" "0.961" "0.862" "0.997" "1.283" "0.772" "0.859" "27.1" "25.4" "27.2" "27.8" "26.1" "23.4" "27.1" "34.8" "20.9" "23.3" "" "" "" "" "" "" "" "" "" "" "27.1" "21.5" "17.2" "20.3" "21.4" "18.2" "20.9" "30.0" "16.4" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "18.562" "19" "5" "6" "5" "257" "28.0" "11.03" "16.57" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Cytoplasmic ribosomal proteins" "Protein hydroxylation; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.024" "1.306" "0.937" "1.054" "1.486" "1.113" "1.264" "1.581" "1.228" "210.0" "215.0" "274.3" "196.7" "221.4" "311.9" "233.6" "265.3" "331.9" "257.9" "" "" "" "" "" "" "" "" "" "" "210.0" "181.9" "173.5" "143.4" "181.4" "242.3" "180.1" "228.1" "259.1" "231.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "18.551" "13" "6" "7" "6" "529" "60.7" "5.16" "21.02" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "7" "0" "1.028" "1.076" "1.084" "1.066" "1.072" "0.988" "1.049" "1.064" "1.147" "217.4" "223.4" "233.8" "235.8" "231.7" "233.0" "214.7" "228.1" "231.4" "249.4" "" "" "" "" "" "" "" "" "" "" "217.4" "189.0" "147.9" "171.9" "189.8" "180.9" "165.5" "196.1" "180.6" "224.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "18.542" "14" "4" "8" "3" "301" "33.4" "5.60" "22.24" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "" "Neutrophil degranulation; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "0.985" "0.912" "0.918" "1.063" "0.932" "1.090" "0.995" "0.928" "0.949" "122.2" "120.3" "111.4" "112.1" "129.9" "113.8" "133.1" "121.5" "113.4" "116.0" "" "" "" "" "" "" "" "" "" "" "122.2" "101.8" "70.4" "81.7" "106.4" "88.4" "102.6" "104.5" "88.5" "104.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "18.542" "12" "5" "6" "5" "581" "62.5" "9.45" "15.44" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "18.511" "7" "5" "5" "5" "824" "92.2" "6.95" "17.62" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "mRNA processing; Male infertility" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "4" "0" "1.060" "0.702" "1.054" "1.162" "0.744" "1.191" "1.112" "0.761" "1.023" "304.1" "322.4" "213.5" "320.7" "353.4" "226.2" "362.4" "338.2" "231.4" "311.2" "" "" "" "" "" "" "" "" "" "" "304.1" "272.7" "135.0" "233.8" "289.6" "175.6" "279.3" "290.8" "180.6" "279.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "18.496" "12" "3" "10" "2" "225" "25.5" "9.72" "31.07" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "0.946" "0.982" "0.999" "0.873" "0.981" "0.994" "1.044" "0.957" "0.903" "564.5" "533.9" "554.4" "563.9" "492.6" "553.8" "560.9" "589.6" "540.5" "509.8" "" "" "" "" "" "" "" "" "" "" "564.5" "451.7" "350.6" "411.1" "403.6" "430.1" "432.4" "507.0" "421.9" "458.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "18.490" "9" "5" "5" "4" "655" "74.3" "6.16" "16.91" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "VEGFA-VEGFR2 signaling; mRNA processing" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "4" "0" "1.028" "0.835" "0.982" "1.157" "0.894" "1.005" "1.018" "1.049" "1.074" "269.3" "276.7" "225.0" "264.4" "311.5" "240.6" "270.5" "274.1" "282.6" "289.3" "" "" "" "" "" "" "" "" "" "" "269.3" "234.1" "142.2" "192.8" "255.2" "186.9" "208.5" "235.7" "220.6" "260.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5795774045568999421" "False" "High" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "0.000" "False" "18.485" "8" "4" "4" "4" "859" "96.3" "9.06" "13.77" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "18.478" "27" "5" "6" "5" "222" "25.4" "10.02" "20.54" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.061" "1.162" "1.082" "1.132" "1.113" "1.096" "1.059" "1.157" "1.102" "313.6" "332.8" "364.4" "339.2" "355.0" "349.1" "343.6" "332.0" "362.9" "345.6" "" "" "" "" "" "" "" "" "" "" "313.6" "281.6" "230.4" "247.3" "290.8" "271.1" "264.9" "285.4" "283.3" "310.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "18.476" "5" "3" "4" "3" "630" "68.0" "5.01" "16.07" "3" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "8" "0" "0.905" "0.830" "1.004" "0.936" "0.877" "1.055" "1.049" "0.926" "0.965" "346.8" "313.7" "288.0" "348.1" "324.4" "304.0" "365.9" "363.9" "321.0" "334.5" "" "" "" "" "" "" "" "" "" "" "346.8" "265.4" "182.1" "253.8" "265.8" "236.1" "282.0" "312.9" "250.5" "300.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "18.458" "4" "5" "6" "5" "1391" "155.1" "6.16" "17.16" "5" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.096" "0.962" "1.086" "1.164" "0.985" "1.060" "1.145" "0.962" "1.045" "130.2" "142.7" "125.3" "141.4" "151.6" "128.2" "138.1" "149.0" "125.2" "136.1" "" "" "" "" "" "" "" "" "" "" "130.2" "120.8" "79.2" "103.1" "124.2" "99.6" "106.4" "128.1" "97.7" "122.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "18.456" "10" "6" "8" "6" "489" "54.2" "5.88" "23.21" "6" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "1.214" "1.185" "1.230" "1.161" "1.107" "1.045" "1.239" "1.226" "1.192" "271.0" "328.9" "321.2" "333.3" "314.8" "300.0" "283.3" "335.8" "332.4" "322.9" "" "" "" "" "" "" "" "" "" "" "271.0" "278.2" "203.1" "243.0" "257.9" "232.9" "218.4" "288.7" "259.5" "290.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "18.452" "13" "6" "6" "6" "476" "54.4" "8.25" "15.11" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "18" "0" "0.984" "0.856" "1.051" "1.054" "0.791" "1.035" "1.048" "0.828" "1.009" "318.4" "313.4" "272.7" "334.7" "335.6" "251.9" "329.4" "333.5" "263.8" "321.4" "" "" "" "" "" "" "" "" "" "" "318.4" "265.1" "172.4" "244.1" "274.9" "195.6" "253.9" "286.8" "205.9" "289.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "18.451" "17" "5" "6" "5" "274" "29.0" "5.58" "18.83" "5" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "Detoxification of Reactive Oxygen Species" "3" "0" "1.038" "1.096" "1.104" "1.066" "1.083" "1.188" "1.171" "1.042" "1.185" "192.9" "200.3" "211.3" "213.0" "205.7" "208.9" "229.2" "225.9" "201.1" "228.5" "" "" "" "" "" "" "" "" "" "" "192.9" "169.4" "133.6" "155.3" "168.5" "162.2" "176.7" "194.3" "156.9" "205.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765040120545487283" "False" "High" "IsMasterProtein" "Q8IXQ6" "Protein mono-ADP-ribosyltransferase PARP9 OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2" "0.000" "False" "18.446" "6" "6" "8" "6" "854" "96.3" "7.91" "19.33" "6" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01661" "83666" "ENSG00000138496" "PARP9" "A8KA94; B2R8S9; E9PFM7; hsa:83666; Q8IXQ6; Q8TCP3; Q9BZL8; Q9BZL9" "" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "3" "0" "1.072" "1.086" "1.081" "1.192" "1.123" "0.977" "0.995" "1.058" "1.317" "106.5" "114.2" "115.7" "115.2" "127.0" "119.7" "104.1" "106.1" "112.7" "140.3" "" "" "" "" "" "" "" "" "" "" "106.5" "96.6" "73.2" "84.0" "104.1" "92.9" "80.2" "91.2" "88.0" "126.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "18.439" "9" "3" "6" "1" "375" "41.6" "7.74" "19.44" "3" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "" "FGFR2 alternative splicing" "1" "0" "1.158" "1.005" "0.980" "1.027" "1.110" "1.138" "0.913" "1.137" "1.060" "102.2" "118.3" "102.7" "100.2" "104.9" "113.4" "116.3" "93.3" "116.2" "108.3" "" "" "" "" "" "" "" "" "" "" "102.2" "100.1" "64.9" "73.0" "85.9" "88.0" "89.6" "80.2" "90.7" "97.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327497704722334246" "False" "High" "IsMasterProtein" "Q14894" "Ketimine reductase mu-crystallin OS=Homo sapiens OX=9606 GN=CRYM PE=1 SV=1" "0.000" "False" "18.431" "16" "5" "5" "5" "314" "33.8" "5.14" "17.20" "5" "other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02423" "1428" "ENSG00000103316" "CRYM" "D5MNX0; hsa:1428; Q14894; Q5HYB7" "" "Lysine catabolism" "1" "0" "0.889" "0.983" "0.834" "0.938" "0.948" "0.937" "0.982" "0.945" "0.939" "276.9" "246.3" "272.3" "231.0" "259.6" "262.6" "259.4" "272.0" "261.6" "259.9" "" "" "" "" "" "" "" "" "" "" "276.9" "208.4" "172.2" "168.4" "212.7" "203.9" "200.0" "233.8" "204.2" "233.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "18.429" "10" "2" "8" "1" "191" "21.2" "6.55" "23.29" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RHO GTPases Activate Formins; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "63" "0" "0.836" "1.023" "0.850" "0.862" "1.028" "0.997" "0.946" "0.958" "0.972" "448.5" "375.0" "458.8" "381.2" "386.5" "461.0" "447.3" "424.4" "429.5" "435.8" "" "" "" "" "" "" "" "" "" "" "448.5" "317.2" "290.1" "277.9" "316.7" "358.0" "344.8" "364.9" "335.3" "391.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307754887580196146" "False" "High" "IsMasterProtein" "Q13287" "N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2" "0.000" "False" "18.411" "12" "4" "7" "4" "307" "35.0" "5.34" "23.21" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "9111" "ENSG00000123609" "NMI" "B5BU69; hsa:9111; Q13287; Q53TI8; Q8WTW2; Q9BVE5" "IL-2 signaling pathway" "SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "1.006" "1.079" "0.994" "1.071" "1.003" "0.963" "1.042" "0.990" "0.934" "538.8" "542.2" "581.6" "535.7" "577.3" "540.5" "518.8" "561.6" "533.7" "503.1" "" "" "" "" "" "" "" "" "" "" "538.8" "458.7" "367.8" "390.6" "473.0" "419.7" "399.9" "482.8" "416.5" "452.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1229807806236447203" "False" "High" "IsMasterProtein" "Q7Z7L1" "Schlafen family member 11 OS=Homo sapiens OX=9606 GN=SLFN11 PE=1 SV=2" "0.000" "False" "18.403" "6" "5" "6" "5" "901" "102.8" "7.77" "16.76" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "91607" "ENSG00000172716" "SLFN11" "E1P643; hsa:91607; Q7Z7L1; Q8N3S8; Q8N762; Q8TEE0" "17q12 copy number variation syndrome" "" "1" "0" "0.918" "0.805" "1.018" "0.978" "0.811" "1.091" "1.029" "0.720" "0.962" "282.0" "258.7" "227.0" "287.1" "275.9" "228.8" "307.8" "290.1" "202.9" "271.3" "" "" "" "" "" "" "" "" "" "" "282.0" "218.9" "143.5" "209.4" "226.0" "177.7" "237.2" "249.4" "158.4" "243.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "18.398" "7" "2" "3" "2" "483" "57.7" "9.48" "13.21" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "0.965" "0.988" "1.076" "1.121" "1.013" "1.190" "0.989" "1.047" "1.072" "217.4" "209.7" "214.8" "233.9" "243.7" "220.2" "258.7" "215.0" "227.8" "233.1" "" "" "" "" "" "" "" "" "" "" "217.4" "177.4" "135.8" "170.5" "199.7" "171.0" "199.4" "184.9" "177.8" "209.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490107994498796069" "False" "High" "IsMasterProtein" "Q8WVC0" "RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1" "0.000" "False" "18.379" "11" "7" "7" "7" "666" "75.4" "4.51" "17.24" "7" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf04004" "123169" "ENSG00000166477" "LEO1" "hsa:123169; Q8WVC0; Q96N99" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "6" "0" "1.061" "0.963" "1.002" "1.075" "1.038" "1.060" "1.033" "1.069" "0.972" "399.9" "424.3" "385.2" "400.8" "430.0" "415.2" "424.0" "412.9" "427.5" "388.7" "" "" "" "" "" "" "" "" "" "" "399.9" "359.0" "243.5" "292.2" "352.3" "322.5" "326.8" "355.0" "333.7" "349.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1086503050039846823" "False" "High" "IsMasterProtein" "Q15847" "Adipogenesis regulatory factor OS=Homo sapiens OX=9606 GN=ADIRF PE=1 SV=1" "0.000" "False" "18.375" "38" "3" "7" "3" "76" "7.9" "5.31" "25.65" "3" "other biological processes" "cytosol;nucleus" "" "" "10974" "ENSG00000148671" "ADIRF" "hsa:10974; Q15847" "10q22q23 copy number variation" "Transcriptional regulation of white adipocyte differentiation" "2" "0" "0.996" "1.075" "0.985" "0.974" "1.032" "1.094" "0.996" "1.083" "0.874" "801.7" "798.7" "861.7" "789.8" "781.0" "827.7" "876.7" "798.6" "868.1" "700.7" "" "" "" "" "" "" "" "" "" "" "801.7" "675.7" "544.8" "575.9" "639.9" "642.8" "675.8" "686.6" "677.6" "629.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "18.361" "35" "5" "10" "5" "122" "14.2" "6.81" "32.61" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.968" "1.067" "0.945" "0.912" "0.978" "0.958" "0.905" "1.022" "0.959" "1070.8" "1036.8" "1143.0" "1012.2" "976.8" "1046.9" "1026.0" "968.8" "1094.1" "1027.0" "" "" "" "" "" "" "" "" "" "" "1070.8" "877.2" "722.8" "738.1" "800.3" "813.0" "790.8" "833.0" "854.0" "923.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "18.351" "14" "5" "6" "5" "360" "41.1" "6.64" "18.21" "5" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "" "snRNP Assembly" "1" "0" "0.997" "0.819" "0.992" "0.949" "0.852" "0.999" "0.977" "0.862" "0.925" "455.8" "454.5" "373.4" "452.2" "432.7" "388.5" "455.4" "445.1" "393.0" "421.8" "" "" "" "" "" "" "" "" "" "" "455.8" "384.5" "236.1" "329.7" "354.5" "301.7" "351.0" "382.7" "306.7" "379.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.000" "False" "18.339" "6" "3" "4" "3" "601" "68.8" "6.29" "15.49" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.013" "0.774" "0.999" "1.011" "1.005" "0.960" "0.878" "0.894" "1.081" "158.8" "160.8" "122.9" "158.6" "160.5" "159.5" "152.4" "139.4" "141.9" "171.6" "" "" "" "" "" "" "" "" "" "" "158.8" "136.0" "77.7" "115.7" "131.5" "123.9" "117.5" "119.8" "110.8" "154.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "18.321" "5" "4" "4" "4" "952" "102.9" "7.58" "12.54" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Regulation of PTEN gene transcription; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "13" "0" "1.170" "1.031" "1.161" "1.130" "1.046" "1.190" "1.093" "0.979" "1.007" "250.5" "293.1" "258.4" "290.8" "283.2" "262.1" "298.1" "273.9" "245.2" "252.3" "" "" "" "" "" "" "" "" "" "" "250.5" "247.9" "163.4" "212.1" "232.0" "203.5" "229.8" "235.5" "191.4" "226.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "18.289" "7" "5" "6" "5" "631" "70.7" "7.42" "20.26" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "0.987" "0.736" "0.995" "0.954" "0.723" "0.966" "1.005" "0.710" "0.855" "346.2" "341.9" "254.9" "344.4" "330.4" "250.5" "334.6" "348.0" "245.8" "295.9" "" "" "" "" "" "" "" "" "" "" "346.2" "289.2" "161.2" "251.2" "270.7" "194.5" "257.9" "299.2" "191.9" "266.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "18.284" "21" "4" "8" "4" "178" "20.2" "9.60" "24.98" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.915" "1.321" "0.982" "1.120" "1.187" "1.029" "1.154" "1.983" "1.198" "128.4" "117.4" "169.6" "126.0" "143.7" "152.3" "132.1" "148.1" "254.5" "153.8" "" "" "" "" "" "" "" "" "" "" "128.4" "99.3" "107.2" "91.9" "117.8" "118.3" "101.8" "127.3" "198.7" "138.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896228887821211438" "False" "High" "IsMasterProtein" "P58004" "Sestrin-2 OS=Homo sapiens OX=9606 GN=SESN2 PE=1 SV=1" "0.000" "False" "18.260" "9" "3" "6" "3" "480" "54.5" "5.90" "14.07" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf04636" "83667" "ENSG00000130766; ENSG00000285069" "SESN2" "hsa:83667; P58004; Q5T7D0; Q96SI5" "Head and neck squamous cell carcinoma; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes; KEAP1-NFE2L2 pathway; Amino acids regulate mTORC1" "5" "0" "0.842" "0.747" "1.138" "1.091" "0.854" "1.087" "1.002" "0.960" "0.922" "61.0" "51.3" "45.5" "69.3" "66.5" "52.1" "66.2" "61.1" "58.5" "56.2" "" "" "" "" "" "" "" "" "" "" "61.0" "43.4" "28.8" "50.6" "54.5" "40.4" "51.1" "52.5" "45.7" "50.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1071096790058741915" "False" "High" "IsMasterProtein" "P46199" "Translation initiation factor IF-2, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF2 PE=1 SV=2" "0.000" "False" "18.257" "6" "5" "6" "5" "727" "81.3" "7.15" "20.27" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf11987" "4528" "ENSG00000085760" "MTIF2" "D6W5D0; hsa:4528; P46199" "" "Mitochondrial translation initiation" "1" "0" "0.999" "0.890" "0.919" "1.027" "0.984" "0.946" "1.048" "0.924" "1.036" "242.3" "242.1" "215.6" "222.7" "248.7" "238.4" "229.2" "254.0" "223.8" "250.9" "" "" "" "" "" "" "" "" "" "" "242.3" "204.8" "136.3" "162.4" "203.8" "185.2" "176.6" "218.4" "174.7" "225.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "18.254" "21" "4" "5" "4" "190" "21.8" "8.90" "17.04" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.046" "0.924" "1.066" "1.017" "0.871" "1.007" "0.934" "1.013" "0.985" "199.4" "208.6" "184.3" "212.6" "202.9" "173.6" "200.8" "186.2" "202.0" "196.3" "" "" "" "" "" "" "" "" "" "" "199.4" "176.5" "116.5" "155.0" "166.2" "134.8" "154.8" "160.1" "157.7" "176.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "18.247" "15" "6" "7" "4" "371" "43.7" "9.92" "23.70" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.104" "1.141" "1.013" "1.134" "1.188" "1.021" "1.075" "1.191" "1.078" "296.3" "327.2" "338.1" "300.1" "336.1" "352.0" "302.6" "318.4" "352.9" "319.4" "" "" "" "" "" "" "" "" "" "" "296.3" "276.8" "213.8" "218.8" "275.4" "273.4" "233.3" "273.8" "275.4" "287.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "18.244" "5" "4" "4" "4" "963" "104.8" "7.74" "14.13" "4" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "" "Nef mediated downregulation of MHC class I complex cell surface expression" "1" "0" "1.036" "0.992" "1.104" "1.098" "1.023" "1.165" "1.161" "1.006" "1.060" "289.8" "300.1" "287.4" "320.1" "318.1" "296.6" "337.8" "336.5" "291.5" "307.2" "" "" "" "" "" "" "" "" "" "" "289.8" "253.9" "181.8" "233.4" "260.7" "230.4" "260.4" "289.3" "227.5" "276.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521587421576138717" "False" "High" "IsMasterProtein" "Q12800" "Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2" "0.000" "False" "18.234" "13" "5" "5" "3" "502" "57.2" "5.80" "19.25" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7024" "ENSG00000135457" "TFCP2" "A8K5E9; hsa:7024; Q12800; Q12801; Q9UD75; Q9UD77" "VEGFA-VEGFR2 signaling" "" "1" "1" "0.925" "1.047" "0.997" "0.991" "0.973" "1.022" "1.062" "0.945" "0.886" "377.1" "348.9" "394.8" "376.1" "373.6" "366.8" "385.4" "400.5" "356.3" "334.1" "" "" "" "" "" "" "" "" "" "" "377.1" "295.2" "249.6" "274.2" "306.1" "284.9" "297.1" "344.4" "278.1" "300.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "18.209" "18" "4" "7" "3" "210" "22.8" "5.14" "21.26" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "1" "0.877" "0.800" "0.873" "0.941" "0.868" "1.022" "0.857" "0.842" "0.871" "297.9" "261.4" "238.3" "260.2" "280.4" "258.7" "304.4" "255.2" "250.8" "259.5" "" "" "" "" "" "" "" "" "" "" "297.9" "221.2" "150.7" "189.7" "229.8" "200.9" "234.6" "219.4" "195.8" "233.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "18.197" "24" "2" "6" "2" "98" "11.1" "7.56" "24.23" "2" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "" "Neutrophil degranulation" "1" "0" "1.127" "1.185" "1.080" "1.150" "1.273" "1.000" "1.175" "1.119" "1.147" "87.5" "98.6" "103.7" "94.5" "100.6" "111.4" "87.5" "102.8" "97.9" "100.4" "" "" "" "" "" "" "" "" "" "" "87.5" "83.4" "65.6" "68.9" "82.5" "86.5" "67.4" "88.4" "76.4" "90.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "18.196" "10" "7" "8" "4" "672" "73.6" "8.72" "22.39" "7" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "1.027" "0.862" "1.103" "1.164" "1.158" "1.010" "1.176" "1.079" "0.976" "97.7" "100.4" "84.2" "107.8" "113.7" "113.1" "98.7" "114.9" "105.4" "95.4" "" "" "" "" "" "" "" "" "" "" "97.7" "84.9" "53.2" "78.6" "93.1" "87.9" "76.1" "98.8" "82.3" "85.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5022575274388480768" "False" "High" "IsMasterProtein" "P28161" "Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2" "0.000" "False" "18.174" "22" "5" "7" "2" "218" "25.7" "6.37" "18.50" "5" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00043, Pf02798" "2946" "ENSG00000213366" "GSTM2" "B4DRY4; E9PEM9; hsa:2946; P28161; Q2M318; Q5TZY5; Q8WWE1" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; FOXA2 pathway; Metapathway biotransformation Phase I and II" "Glutathione conjugation" "6" "3" "1.134" "0.974" "1.081" "1.137" "1.066" "1.020" "1.003" "0.955" "0.984" "296.8" "336.7" "289.1" "320.9" "337.6" "316.3" "302.8" "297.6" "283.3" "291.9" "" "" "" "" "" "" "" "" "" "" "296.8" "284.8" "182.8" "234.0" "276.6" "245.7" "233.4" "255.9" "221.2" "262.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "18.174" "9" "3" "3" "3" "392" "42.2" "6.32" "12.74" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "0.953" "1.012" "0.956" "0.844" "0.951" "1.059" "1.006" "0.952" "1.094" "158.6" "151.1" "160.5" "151.6" "133.8" "150.8" "168.0" "159.6" "151.1" "173.5" "" "" "" "" "" "" "" "" "" "" "158.6" "127.9" "101.5" "110.5" "109.7" "117.1" "129.5" "137.2" "117.9" "156.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "18.167" "11" "3" "6" "3" "372" "42.0" "5.31" "16.66" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.082" "0.985" "1.139" "1.105" "1.124" "1.175" "1.126" "1.080" "1.082" "168.9" "182.6" "166.4" "192.4" "186.6" "189.8" "198.4" "190.2" "182.4" "182.7" "" "" "" "" "" "" "" "" "" "" "168.9" "154.5" "105.2" "140.3" "152.9" "147.4" "152.9" "163.5" "142.4" "164.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "18.154" "13" "4" "5" "4" "423" "46.6" "5.95" "15.15" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "N-glycan biosynthesis" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "3" "0" "0.970" "1.072" "0.943" "0.904" "1.006" "0.964" "0.974" "1.064" "1.053" "193.3" "187.5" "207.3" "182.3" "174.8" "194.4" "186.4" "188.4" "205.8" "203.6" "" "" "" "" "" "" "" "" "" "" "193.3" "158.6" "131.1" "132.9" "143.2" "151.0" "143.7" "161.9" "160.6" "183.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "18.120" "6" "3" "5" "3" "567" "63.5" "9.98" "19.46" "3" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "0.932" "0.811" "0.960" "1.053" "0.986" "0.895" "0.986" "0.839" "0.898" "85.9" "80.1" "69.7" "82.5" "90.5" "84.8" "76.9" "84.7" "72.1" "77.2" "" "" "" "" "" "" "" "" "" "" "85.9" "67.8" "44.1" "60.2" "74.2" "65.8" "59.3" "72.8" "56.3" "69.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "18.118" "8" "6" "7" "6" "821" "88.1" "5.27" "19.37" "6" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "0.823" "0.544" "0.767" "0.959" "0.804" "0.812" "0.817" "0.728" "0.903" "34.7" "28.6" "18.9" "26.6" "33.3" "27.9" "28.1" "28.3" "25.3" "31.3" "" "" "" "" "" "" "" "" "" "" "34.7" "24.2" "11.9" "19.4" "27.2" "21.6" "21.7" "24.3" "19.7" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "201437280160465728" "False" "High" "IsMasterProtein" "Q9H9E3" "Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3" "0.000" "False" "18.098" "6" "4" "5" "4" "785" "89.0" "5.19" "16.64" "4" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08318, Pf20662, Pf20663" "25839" "ENSG00000103051" "COG4" "B4DMN8; C9JS23; hsa:25839; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9H9E3; Q9Y3W3" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.941" "0.920" "1.174" "0.995" "1.047" "0.987" "0.901" "0.915" "0.974" "25.6" "24.1" "23.6" "30.0" "25.5" "26.8" "25.3" "23.1" "23.4" "24.9" "" "" "" "" "" "" "" "" "" "" "25.6" "20.4" "14.9" "21.9" "20.9" "20.8" "19.5" "19.8" "18.3" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "18.080" "16" "4" "9" "4" "201" "22.8" "7.02" "26.61" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.145" "1.095" "1.200" "1.085" "1.139" "1.063" "1.084" "1.153" "1.145" "408.6" "467.8" "447.3" "490.2" "443.5" "465.4" "434.4" "443.1" "471.3" "467.9" "" "" "" "" "" "" "" "" "" "" "408.6" "395.8" "282.9" "357.4" "363.4" "361.5" "334.8" "380.9" "367.9" "420.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "18.069" "8" "3" "5" "3" "399" "45.3" "7.75" "14.91" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.025" "1.105" "0.960" "1.036" "1.157" "0.985" "1.116" "1.120" "1.109" "393.4" "403.1" "434.7" "377.6" "407.7" "455.3" "387.5" "439.0" "440.8" "436.2" "" "" "" "" "" "" "" "" "" "" "393.4" "341.0" "274.8" "275.3" "334.0" "353.6" "298.7" "377.4" "344.1" "392.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "18.048" "32" "4" "7" "4" "167" "19.3" "6.51" "19.34" "4" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "1.043" "0.737" "1.083" "1.026" "0.926" "1.181" "1.133" "0.918" "1.043" "107.7" "112.3" "79.3" "116.6" "110.4" "99.7" "127.1" "122.0" "98.8" "112.3" "" "" "" "" "" "" "" "" "" "" "107.7" "95.0" "50.2" "85.0" "90.5" "77.4" "98.0" "104.9" "77.1" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "18.044" "19" "5" "6" "5" "304" "34.7" "8.53" "15.62" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "0.968" "0.964" "0.953" "0.965" "0.929" "0.985" "0.953" "1.091" "0.963" "144.8" "140.1" "139.5" "137.9" "139.7" "134.4" "142.6" "138.0" "158.0" "139.3" "" "" "" "" "" "" "" "" "" "" "144.8" "118.6" "88.2" "100.6" "114.5" "104.4" "109.9" "118.6" "123.3" "125.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "18.043" "5" "5" "5" "5" "951" "104.0" "8.09" "18.33" "5" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "Sudden infant death syndrome (SIDS) susceptibility pathways" "" "1" "0" "1.118" "1.119" "1.162" "1.161" "1.010" "1.072" "1.197" "1.025" "1.059" "188.7" "211.1" "211.1" "219.3" "219.1" "190.6" "202.3" "225.9" "193.5" "199.9" "" "" "" "" "" "" "" "" "" "" "188.7" "178.6" "133.5" "159.9" "179.5" "148.0" "155.9" "194.2" "151.0" "179.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "18.032" "23" "4" "9" "4" "230" "26.2" "4.92" "27.39" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Proteasome degradation" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation" "4" "0" "1.016" "1.061" "1.135" "1.074" "1.062" "1.125" "1.041" "1.091" "1.037" "347.5" "352.9" "368.8" "394.5" "373.3" "368.9" "391.0" "361.9" "379.2" "360.2" "" "" "" "" "" "" "" "" "" "" "347.5" "298.6" "233.2" "287.6" "305.9" "286.5" "301.4" "311.1" "296.0" "323.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "18.011" "5" "5" "6" "5" "1066" "114.1" "7.08" "19.28" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Male infertility" "Neddylation" "2" "0" "0.992" "0.931" "1.090" "1.075" "1.199" "1.144" "1.090" "1.119" "0.937" "165.3" "164.0" "154.0" "180.2" "177.8" "198.2" "189.1" "180.2" "185.0" "154.9" "" "" "" "" "" "" "" "" "" "" "165.3" "138.8" "97.4" "131.4" "145.6" "153.9" "145.8" "155.0" "144.4" "139.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "17.996" "4" "6" "7" "6" "1621" "181.6" "7.05" "17.39" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "1.104" "0.933" "1.018" "1.151" "0.985" "1.112" "1.121" "1.030" "1.098" "401.6" "443.3" "374.8" "408.9" "462.2" "395.7" "446.5" "450.3" "413.7" "441.0" "" "" "" "" "" "" "" "" "" "" "401.6" "375.0" "237.0" "298.1" "378.7" "307.3" "344.2" "387.1" "322.9" "396.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "17.994" "16" "3" "5" "3" "176" "19.4" "4.75" "18.77" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "2" "0" "0.981" "1.011" "1.022" "1.066" "1.057" "1.109" "0.967" "0.982" "1.034" "292.9" "287.3" "296.1" "299.4" "312.2" "309.6" "324.9" "283.2" "287.6" "302.9" "" "" "" "" "" "" "" "" "" "" "292.9" "243.0" "187.2" "218.3" "255.8" "240.4" "250.4" "243.5" "224.5" "272.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "17.972" "25" "4" "7" "4" "166" "19.2" "7.34" "23.31" "4" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.116" "1.190" "0.877" "1.030" "1.107" "1.003" "0.957" "1.037" "1.104" "251.1" "280.3" "298.8" "220.2" "258.7" "278.0" "252.0" "240.3" "260.5" "277.4" "" "" "" "" "" "" "" "" "" "" "251.1" "237.2" "189.0" "160.6" "211.9" "215.9" "194.2" "206.6" "203.3" "249.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515623990102163669" "False" "High" "IsMasterProtein" "P51161" "Gastrotropin OS=Homo sapiens OX=9606 GN=FABP6 PE=1 SV=2" "0.000" "False" "17.968" "27" "3" "4" "3" "128" "14.4" "6.80" "13.70" "3" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14651" "2172" "ENSG00000170231" "FABP6" "hsa:2172; P51161; Q07DR7; Q8TBI3; Q9UGI7" "PPAR signaling pathway; Fatty acid transporters" "Triglyceride catabolism; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "5" "0" "1.056" "1.069" "0.981" "1.045" "1.153" "0.914" "0.958" "0.980" "1.119" "166.7" "176.0" "178.3" "163.6" "174.3" "192.2" "152.4" "159.7" "163.3" "186.6" "" "" "" "" "" "" "" "" "" "" "166.7" "148.9" "112.7" "119.3" "142.8" "149.3" "117.4" "137.3" "127.5" "167.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "17.941" "21" "5" "5" "4" "277" "31.6" "6.54" "12.42" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; Caspase-mediated cleavage of cytoskeletal proteins; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "60" "0" "1.121" "0.910" "1.104" "1.127" "0.994" "1.054" "1.072" "1.009" "1.011" "196.5" "220.4" "178.8" "216.9" "221.5" "195.2" "207.1" "210.6" "198.4" "198.7" "" "" "" "" "" "" "" "" "" "" "196.5" "186.4" "113.0" "158.1" "181.4" "151.6" "159.7" "181.1" "154.8" "178.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "17.900" "16" "5" "6" "5" "366" "39.3" "7.85" "18.74" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.070" "1.018" "1.162" "1.130" "1.068" "1.073" "1.105" "1.039" "1.087" "282.2" "302.0" "287.2" "327.9" "318.8" "301.4" "302.7" "311.9" "293.1" "306.8" "" "" "" "" "" "" "" "" "" "" "282.2" "255.5" "181.6" "239.1" "261.2" "234.0" "233.3" "268.2" "228.8" "275.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "17.890" "18" "6" "6" "6" "270" "29.7" "6.04" "17.66" "6" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "" "Degradation of cysteine and homocysteine" "1" "0" "1.033" "0.911" "0.997" "1.056" "1.028" "1.046" "1.057" "0.950" "1.032" "212.1" "219.1" "193.2" "211.5" "223.8" "217.9" "221.8" "224.2" "201.5" "218.9" "" "" "" "" "" "" "" "" "" "" "212.1" "185.4" "122.2" "154.2" "183.4" "169.2" "171.0" "192.8" "157.3" "196.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "17.880" "10" "4" "5" "4" "361" "39.3" "7.18" "17.71" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "17.865" "2" "4" "5" "2" "2442" "265.2" "8.53" "17.45" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Heme signaling; Formation of the beta-catenin:TCF transactivating complex; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NFE2L2 regulating anti-oxidant/detoxification enzymes; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "74" "0" "1.030" "1.002" "1.101" "0.998" "1.005" "1.066" "0.950" "0.910" "0.953" "192.2" "197.9" "192.6" "211.6" "191.8" "193.3" "204.8" "182.6" "174.9" "183.2" "" "" "" "" "" "" "" "" "" "" "192.2" "167.4" "121.8" "154.3" "157.1" "150.1" "157.9" "157.0" "136.5" "164.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "17.859" "5" "6" "7" "5" "1032" "112.9" "7.25" "23.49" "6" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.044" "0.924" "1.024" "0.906" "0.916" "0.939" "0.959" "0.963" "0.999" "366.9" "383.2" "339.1" "375.8" "332.6" "336.3" "344.5" "352.1" "353.4" "366.6" "" "" "" "" "" "" "" "" "" "" "366.9" "324.2" "214.4" "274.0" "272.5" "261.1" "265.5" "302.7" "275.9" "329.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "17.840" "25" "2" "3" "2" "112" "12.9" "4.84" "12.41" "2" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "1.012" "0.950" "1.017" "1.100" "1.052" "1.050" "1.038" "0.890" "0.938" "210.1" "212.8" "199.6" "213.8" "231.1" "221.1" "220.6" "218.1" "187.1" "197.1" "" "" "" "" "" "" "" "" "" "" "210.1" "180.0" "126.2" "155.9" "189.3" "171.7" "170.0" "187.6" "146.1" "177.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "High" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.000" "False" "17.832" "6" "6" "6" "6" "897" "100.9" "6.90" "16.23" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "4" "0" "1.001" "0.796" "0.941" "1.061" "0.991" "1.017" "0.947" "0.847" "0.927" "350.8" "351.0" "279.3" "330.2" "372.3" "347.5" "356.7" "332.3" "297.0" "325.2" "" "" "" "" "" "" "" "" "" "" "350.8" "296.9" "176.6" "240.8" "305.0" "269.8" "275.0" "285.7" "231.9" "292.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "17.812" "17" "4" "6" "4" "268" "28.3" "5.20" "25.26" "4" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Integrin-mediated cell adhesion" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "4" "0" "0.905" "1.038" "1.002" "0.938" "0.957" "1.035" "0.967" "0.921" "0.875" "637.3" "576.9" "661.6" "638.3" "597.8" "609.9" "659.8" "616.2" "587.1" "557.9" "" "" "" "" "" "" "" "" "" "" "637.3" "488.0" "418.3" "465.4" "489.8" "473.6" "508.6" "529.8" "458.3" "501.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "17.803" "4" "8" "8" "8" "2054" "233.0" "6.30" "18.62" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "1.050" "1.187" "1.256" "1.272" "1.144" "1.211" "1.172" "1.112" "1.165" "179.2" "188.2" "212.7" "225.1" "228.0" "205.1" "217.0" "210.0" "199.4" "208.8" "" "" "" "" "" "" "" "" "" "" "179.2" "159.2" "134.5" "164.1" "186.8" "159.3" "167.3" "180.5" "155.6" "187.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "17.788" "8" "4" "4" "4" "538" "57.5" "5.68" "14.05" "4" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "NAD+ biosynthetic pathways" "Neutrophil degranulation; Nicotinamide salvaging" "3" "0" "0.933" "0.910" "1.046" "1.240" "1.312" "1.052" "1.039" "1.203" "1.353" "42.5" "39.7" "38.7" "44.5" "52.8" "55.8" "44.8" "44.2" "51.2" "57.6" "" "" "" "" "" "" "" "" "" "" "42.5" "33.6" "24.5" "32.4" "43.2" "43.3" "34.5" "38.0" "39.9" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "17.787" "16" "2" "4" "2" "140" "15.0" "9.14" "14.71" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.935" "0.857" "0.965" "0.938" "0.819" "0.879" "0.730" "0.956" "1.058" "90.9" "85.1" "78.0" "87.8" "85.3" "74.4" "80.0" "66.3" "87.0" "96.2" "" "" "" "" "" "" "" "" "" "" "90.9" "72.0" "49.3" "64.0" "69.9" "57.8" "61.6" "57.0" "67.9" "86.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3983028009750613022" "False" "High" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "0.000" "False" "17.769" "3" "5" "7" "5" "1335" "148.9" "6.89" "19.12" "5" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "34" "0" "0.912" "0.825" "1.141" "1.038" "0.734" "1.079" "1.075" "0.762" "0.942" "138.0" "125.9" "113.8" "157.3" "143.2" "101.3" "148.8" "148.2" "105.1" "130.0" "" "" "" "" "" "" "" "" "" "" "138.0" "106.5" "72.0" "114.7" "117.3" "78.7" "114.7" "127.5" "82.1" "116.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "17.748" "17" "3" "4" "3" "191" "22.2" "5.86" "13.79" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "5" "0" "1.044" "1.189" "1.020" "1.059" "1.219" "1.094" "1.091" "1.139" "1.118" "328.5" "343.1" "390.6" "335.2" "348.0" "400.6" "359.4" "358.5" "374.2" "367.5" "" "" "" "" "" "" "" "" "" "" "328.5" "290.3" "247.0" "244.4" "285.2" "311.1" "277.1" "308.2" "292.1" "330.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "17.730" "24" "6" "9" "6" "226" "26.1" "8.00" "26.95" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.046" "1.141" "1.139" "1.129" "1.160" "1.080" "1.031" "1.138" "1.146" "94.7" "99.1" "108.1" "107.8" "106.9" "109.9" "102.3" "97.7" "107.8" "108.5" "" "" "" "" "" "" "" "" "" "" "94.7" "83.8" "68.3" "78.6" "87.6" "85.3" "78.8" "84.0" "84.2" "97.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "17.695" "37" "4" "11" "4" "135" "15.5" "9.85" "31.82" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.109" "1.243" "1.119" "1.113" "1.349" "1.192" "1.220" "1.218" "1.097" "398.8" "442.4" "495.7" "446.4" "444.0" "538.1" "475.5" "486.7" "485.7" "437.7" "" "" "" "" "" "" "" "" "" "" "398.8" "374.2" "313.4" "325.5" "363.8" "417.9" "366.5" "418.5" "379.1" "393.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "17.691" "8" "5" "5" "5" "504" "57.5" "6.15" "13.15" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Photodynamic therapy-induced unfolded protein response" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "7" "0" "0.957" "0.825" "1.020" "0.937" "0.875" "0.956" "1.015" "0.789" "0.928" "221.2" "211.7" "182.4" "225.6" "207.2" "193.5" "211.4" "224.6" "174.5" "205.2" "" "" "" "" "" "" "" "" "" "" "221.2" "179.1" "115.3" "164.5" "169.7" "150.3" "162.9" "193.1" "136.2" "184.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "High" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.000" "False" "17.680" "3" "6" "6" "6" "1992" "220.3" "8.48" "15.00" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.250" "1.107" "1.161" "1.135" "1.044" "1.163" "1.165" "1.064" "1.074" "177.2" "221.5" "196.3" "205.8" "201.1" "185.0" "206.1" "206.5" "188.7" "190.4" "" "" "" "" "" "" "" "" "" "" "177.2" "187.4" "124.1" "150.0" "164.8" "143.6" "158.8" "177.5" "147.3" "171.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "17.661" "15" "4" "5" "3" "336" "37.6" "6.84" "16.65" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "Transcriptional Regulation by E2F6; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "11" "0" "1.037" "1.109" "1.182" "1.050" "1.176" "1.255" "1.051" "1.111" "1.201" "121.9" "126.4" "135.2" "144.1" "128.0" "143.4" "153.1" "128.1" "135.4" "146.4" "" "" "" "" "" "" "" "" "" "" "121.9" "107.0" "85.5" "105.1" "104.9" "111.4" "118.0" "110.2" "105.7" "131.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516330367870273472" "False" "High" "IsMasterProtein" "P09086" "POU domain, class 2, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=3" "0.000" "False" "17.659" "9" "4" "7" "2" "479" "51.2" "8.43" "20.48" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5452" "ENSG00000028277" "POU2F2" "hsa:5452; P09086; Q16648; Q7M4M8; Q9BRS4" "Ectoderm differentiation; Prion disease pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RNA polymerase II transcribes snRNA genes" "4" "0" "1.083" "0.952" "0.983" "1.071" "1.036" "1.153" "1.064" "0.897" "0.894" "87.8" "95.2" "83.6" "86.4" "94.0" "91.0" "101.3" "93.5" "78.8" "78.6" "" "" "" "" "" "" "" "" "" "" "87.8" "80.5" "52.9" "63.0" "77.1" "70.7" "78.1" "80.4" "61.5" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5463770494626313283" "False" "High" "IsMasterProtein" "Q9C035" "Tripartite motif-containing protein 5 OS=Homo sapiens OX=9606 GN=TRIM5 PE=1 SV=1" "0.000" "False" "17.659" "10" "5" "6" "5" "493" "56.3" "6.05" "17.27" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "85363" "ENSG00000132256" "TRIM5" "A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; hsa:85363; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034; Q9C035" "Mesodermal commitment pathway" "Interferon gamma signaling" "2" "0" "1.003" "0.893" "1.229" "0.994" "0.981" "1.089" "1.051" "0.972" "1.165" "190.8" "191.5" "170.4" "234.5" "189.7" "187.2" "207.9" "200.6" "185.5" "222.4" "" "" "" "" "" "" "" "" "" "" "190.8" "162.0" "107.8" "171.0" "155.4" "145.4" "160.2" "172.4" "144.8" "199.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "17.658" "17" "4" "8" "3" "292" "33.3" "7.66" "22.37" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "16" "0" "0.947" "0.878" "0.963" "0.970" "0.862" "0.938" "0.938" "0.878" "0.990" "377.9" "357.9" "331.8" "363.9" "366.4" "325.6" "354.3" "354.5" "331.9" "374.1" "" "" "" "" "" "" "" "" "" "" "377.9" "302.8" "209.8" "265.4" "300.2" "252.9" "273.1" "304.8" "259.1" "336.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "17.651" "8" "4" "4" "4" "535" "57.8" "8.50" "13.43" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "" "Branched-chain amino acid catabolism" "1" "0" "1.105" "1.055" "1.193" "1.180" "1.058" "1.097" "1.145" "0.951" "1.104" "145.9" "161.3" "153.9" "174.1" "172.2" "154.3" "160.0" "167.1" "138.8" "161.1" "" "" "" "" "" "" "" "" "" "" "145.9" "136.4" "97.3" "126.9" "141.1" "119.9" "123.4" "143.6" "108.4" "144.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "High" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.000" "False" "17.622" "5" "4" "4" "4" "857" "97.0" "8.16" "14.58" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "Cell cycle; Retinoblastoma gene in cancer" "" "2" "0" "1.008" "0.684" "1.117" "1.029" "0.759" "1.024" "1.060" "0.691" "0.896" "309.2" "311.6" "211.4" "345.4" "318.3" "234.6" "316.5" "327.9" "213.7" "277.1" "" "" "" "" "" "" "" "" "" "" "309.2" "263.7" "133.7" "251.9" "260.8" "182.2" "244.0" "281.9" "166.8" "249.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "17.608" "21" "4" "7" "4" "210" "24.5" "5.95" "25.66" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "1.079" "1.035" "1.104" "1.063" "1.012" "0.977" "1.077" "1.030" "1.149" "404.4" "436.2" "418.6" "446.4" "429.8" "409.5" "395.2" "435.6" "416.5" "464.9" "" "" "" "" "" "" "" "" "" "" "404.4" "369.0" "264.7" "325.5" "352.2" "318.0" "304.6" "374.5" "325.1" "417.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "17.604" "11" "5" "6" "5" "432" "48.5" "6.09" "17.07" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "Male infertility" "" "1" "0" "1.323" "0.872" "1.145" "1.131" "0.913" "1.136" "1.040" "0.896" "1.139" "203.7" "269.5" "177.7" "233.3" "230.5" "186.0" "231.5" "211.9" "182.6" "232.1" "" "" "" "" "" "" "" "" "" "" "203.7" "228.0" "112.3" "170.1" "188.8" "144.5" "178.4" "182.2" "142.5" "208.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "17.600" "2" "5" "5" "5" "3230" "343.3" "5.96" "15.85" "5" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200285318932313306" "False" "High" "IsMasterProtein" "Q9UHR6" "Zinc finger HIT domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZNHIT2 PE=1 SV=1" "0.000" "False" "17.596" "11" "3" "3" "3" "403" "42.9" "5.99" "12.33" "3" "" "" "other molecular function" "Pf04438" "741" "ENSG00000174276" "ZNHIT2" "hsa:741; Q3SY14; Q8IUV0; Q9UHR6" "" "" "0" "0" "1.085" "0.829" "1.221" "1.315" "0.822" "1.121" "1.321" "0.792" "0.916" "62.5" "67.8" "51.8" "76.3" "82.2" "51.4" "70.1" "82.6" "49.5" "57.3" "" "" "" "" "" "" "" "" "" "" "62.5" "57.4" "32.8" "55.6" "67.4" "39.9" "54.0" "71.0" "38.6" "51.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "17.593" "16" "3" "3" "2" "327" "35.1" "5.27" "13.83" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "FCGR3A-mediated IL10 synthesis; HCMV Early Events; ADORA2B mediated anti-inflammatory cytokines production; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "85" "1" "0.994" "0.906" "1.104" "0.950" "1.049" "1.256" "1.042" "1.015" "0.927" "159.1" "158.1" "144.2" "175.6" "151.2" "166.8" "199.8" "165.7" "161.5" "147.5" "" "" "" "" "" "" "" "" "" "" "159.1" "133.8" "91.2" "128.1" "123.8" "129.5" "154.0" "142.5" "126.1" "132.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "17.590" "16" "3" "5" "3" "261" "30.0" "7.06" "17.23" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "Vitamin B6 activation to pyridoxal phosphate" "3" "0" "1.053" "0.920" "1.070" "1.067" "1.028" "1.176" "1.084" "0.897" "1.041" "445.6" "469.0" "409.8" "476.9" "475.7" "457.9" "524.0" "483.2" "399.8" "463.7" "" "" "" "" "" "" "" "" "" "" "445.6" "396.8" "259.1" "347.7" "389.7" "355.6" "403.9" "415.5" "312.1" "416.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "17.589" "3" "2" "3" "2" "1104" "122.8" "5.83" "15.23" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "" "RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Glycosphingolipid transport; RHOD GTPase cycle; RHOF GTPase cycle" "7" "0" "0.927" "1.912" "1.198" "0.903" "1.629" "1.294" "0.959" "1.753" "1.357" "131.0" "121.4" "250.5" "156.9" "118.4" "213.4" "169.5" "125.7" "229.6" "177.8" "" "" "" "" "" "" "" "" "" "" "131.0" "102.7" "158.4" "114.4" "97.0" "165.7" "130.6" "108.1" "179.2" "159.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.000" "False" "17.580" "6" "4" "5" "4" "853" "96.6" "4.94" "16.81" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "11" "0" "1.076" "0.792" "1.192" "1.165" "1.065" "1.323" "1.186" "0.895" "1.175" "123.0" "132.4" "97.5" "146.6" "143.4" "131.0" "162.7" "145.9" "110.1" "144.5" "" "" "" "" "" "" "" "" "" "" "123.0" "112.0" "61.6" "106.9" "117.5" "101.7" "125.4" "125.4" "85.9" "129.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "17.572" "2" "5" "5" "5" "2319" "243.8" "6.90" "15.81" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.965" "0.987" "0.999" "0.986" "1.063" "1.046" "0.894" "0.988" "0.844" "52.5" "50.6" "51.8" "52.4" "51.7" "55.8" "54.9" "46.9" "51.8" "44.3" "" "" "" "" "" "" "" "" "" "" "52.5" "42.8" "32.7" "38.2" "42.4" "43.3" "42.3" "40.3" "40.5" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575582902092764945" "False" "High" "IsMasterProtein" "Q9NQA3" "WAS protein family homolog 6 OS=Homo sapiens OX=9606 GN=WASH6P PE=1 SV=3" "0.000" "False" "17.571" "10" "3" "4" "1" "447" "48.0" "5.67" "14.78" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH6P" "A6NGF1; Q8N305; Q9NQA3" "" "" "0" "0" "0.758" "1.147" "0.923" "1.221" "1.169" "2.389" "1.037" "1.044" "0.922" "43.2" "32.7" "49.5" "39.8" "52.7" "50.5" "103.1" "44.8" "45.1" "39.8" "" "" "" "" "" "" "" "" "" "" "43.2" "27.7" "31.3" "29.1" "43.2" "39.2" "79.5" "38.5" "35.2" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "17.556" "5" "5" "5" "5" "1009" "113.9" "8.60" "15.00" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "Retinoblastoma gene in cancer" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "1.085" "1.128" "1.131" "1.214" "0.970" "1.147" "1.180" "0.826" "0.971" "135.0" "146.5" "152.3" "152.7" "163.9" "130.9" "154.9" "159.4" "111.5" "131.2" "" "" "" "" "" "" "" "" "" "" "135.0" "123.9" "96.3" "111.4" "134.3" "101.7" "119.4" "137.0" "87.0" "118.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "17.545" "21" "4" "7" "4" "174" "19.8" "8.54" "27.13" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.035" "1.022" "0.933" "0.940" "0.916" "0.906" "0.938" "0.954" "0.942" "703.2" "728.1" "718.5" "655.8" "661.1" "644.4" "636.9" "659.6" "671.1" "662.7" "" "" "" "" "" "" "" "" "" "" "703.2" "616.0" "454.3" "478.2" "541.7" "500.4" "491.0" "567.1" "523.8" "595.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "17.543" "13" "3" "4" "3" "238" "27.1" "4.42" "14.27" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "0.899" "0.995" "0.924" "0.952" "1.031" "1.025" "1.070" "0.948" "1.074" "211.6" "190.3" "210.6" "195.5" "201.5" "218.2" "217.0" "226.6" "200.7" "227.2" "" "" "" "" "" "" "" "" "" "" "211.6" "161.0" "133.1" "142.6" "165.1" "169.5" "167.3" "194.8" "156.7" "204.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635055545262344476" "False" "High" "IsMasterProtein" "Q9UER7" "Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2" "0.000" "False" "17.538" "4" "2" "3" "2" "740" "81.3" "4.87" "11.18" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03344, Pf20920" "1616" "ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617" "DAXX" "B4E1I3; F5ANJ6; F5ANJ7; F5H082; hsa:1616; O14747; O15141; O15208; Q5STK9; Q9BWI3; Q9UER7" "Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway" "HCMV Early Events; SUMOylation of transcription cofactors; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "11" "0" "1.110" "0.871" "0.997" "1.057" "0.878" "1.117" "1.043" "0.908" "1.041" "192.1" "213.2" "167.2" "191.5" "203.1" "168.6" "214.5" "200.3" "174.4" "199.9" "" "" "" "" "" "" "" "" "" "" "192.1" "180.3" "105.7" "139.6" "166.4" "131.0" "165.3" "172.2" "136.1" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "17.526" "22" "3" "3" "3" "188" "20.5" "4.17" "13.44" "3" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "0.950" "1.038" "1.088" "1.100" "1.034" "1.057" "1.023" "1.058" "1.124" "185.9" "176.7" "192.9" "202.3" "204.5" "192.3" "196.5" "190.2" "196.7" "208.9" "" "" "" "" "" "" "" "" "" "" "185.9" "149.5" "121.9" "147.5" "167.5" "149.3" "151.5" "163.5" "153.5" "187.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3107820624180600590" "False" "High" "IsMasterProtein" "O75879" "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1" "0.000" "False" "17.524" "8" "5" "5" "5" "557" "61.8" "8.63" "15.55" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf02637, Pf02934" "5188" "ENSG00000059691" "GATB" "hsa:5188; O75879; Q4W5M8; Q53GP4; Q9P0S6; Q9Y2B8" "" "" "0" "0" "0.860" "0.849" "0.924" "1.006" "0.850" "0.896" "0.769" "0.844" "0.881" "304.2" "261.7" "258.3" "281.0" "305.9" "258.6" "272.4" "233.8" "256.7" "268.1" "" "" "" "" "" "" "" "" "" "" "304.2" "221.4" "163.3" "204.9" "250.6" "200.8" "210.0" "201.1" "200.4" "241.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "17.517" "19" "4" "5" "4" "270" "29.2" "6.15" "15.80" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "0.988" "1.005" "0.983" "0.951" "0.943" "0.984" "0.980" "0.973" "0.985" "423.3" "418.4" "425.3" "416.3" "402.8" "399.0" "416.6" "414.7" "411.7" "417.1" "" "" "" "" "" "" "" "" "" "" "423.3" "354.0" "268.9" "303.5" "330.0" "309.9" "321.1" "356.6" "321.3" "375.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "17.512" "29" "3" "10" "3" "115" "12.8" "9.63" "25.92" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.126" "1.623" "1.125" "1.307" "1.858" "1.067" "1.457" "1.886" "1.213" "225.0" "253.4" "365.2" "253.2" "294.0" "418.2" "240.2" "327.7" "424.4" "272.9" "" "" "" "" "" "" "" "" "" "" "225.0" "214.4" "230.9" "184.6" "240.9" "324.7" "185.1" "281.8" "331.3" "245.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "17.508" "19" "8" "9" "8" "412" "46.6" "7.18" "26.46" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.030" "0.862" "1.037" "1.017" "0.819" "0.941" "0.979" "0.846" "0.926" "544.7" "560.8" "469.5" "564.6" "553.7" "445.9" "512.4" "533.2" "460.9" "504.3" "" "" "" "" "" "" "" "" "" "" "544.7" "474.5" "296.9" "411.7" "453.7" "346.3" "395.0" "458.4" "359.8" "453.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "17.507" "5" "5" "5" "5" "950" "106.9" "4.77" "17.75" "5" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "16p11.2 proximal deletion syndrome" "" "1" "0" "0.953" "0.874" "0.974" "0.920" "0.831" "0.993" "0.991" "0.853" "0.950" "463.8" "441.9" "405.4" "451.5" "426.8" "385.6" "460.7" "459.8" "395.8" "440.5" "" "" "" "" "" "" "" "" "" "" "463.8" "373.9" "256.3" "329.2" "349.7" "299.5" "355.2" "395.3" "308.9" "396.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "17.504" "13" "3" "7" "3" "229" "26.6" "5.71" "24.68" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.986" "1.166" "1.001" "1.037" "1.140" "1.176" "0.975" "1.068" "1.030" "510.7" "503.5" "595.6" "511.2" "529.6" "582.2" "600.5" "498.1" "545.3" "525.8" "" "" "" "" "" "" "" "" "" "" "510.7" "426.0" "376.6" "372.7" "433.9" "452.1" "462.9" "428.2" "425.6" "472.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "17.503" "14" "5" "11" "5" "310" "34.6" "6.52" "31.55" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "64" "0" "1.112" "0.958" "0.958" "0.990" "0.862" "0.854" "0.889" "0.875" "1.023" "829.7" "922.8" "795.0" "795.0" "821.2" "714.8" "708.4" "737.8" "726.1" "848.4" "" "" "" "" "" "" "" "" "" "" "829.7" "780.7" "502.7" "579.6" "672.8" "555.1" "546.1" "634.4" "566.8" "762.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "17.493" "8" "1" "2" "1" "222" "25.1" "5.97" "10.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "10" "0" "0.875" "0.836" "0.982" "0.861" "0.707" "0.906" "0.759" "0.872" "0.949" "51.9" "45.5" "43.4" "51.0" "44.7" "36.7" "47.1" "39.4" "45.3" "49.3" "" "" "" "" "" "" "" "" "" "" "51.9" "38.5" "27.4" "37.2" "36.7" "28.5" "36.3" "33.9" "35.4" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7736250579698754769" "False" "High" "IsMasterProtein" "Q8IV53" "DENN domain-containing protein 1C OS=Homo sapiens OX=9606 GN=DENND1C PE=1 SV=1" "0.000" "False" "17.483" "8" "5" "5" "5" "801" "87.0" "5.67" "16.04" "5" "transport" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "79958" "ENSG00000205744" "DENND1C" "B4E051; D3PFD4; hsa:79958; Q8IV53; Q8NDB1; Q9H5Z2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.027" "0.755" "1.145" "0.999" "0.740" "0.877" "0.950" "0.956" "1.087" "61.7" "63.4" "46.6" "70.7" "61.7" "45.7" "54.2" "58.6" "59.0" "67.1" "" "" "" "" "" "" "" "" "" "" "61.7" "53.7" "29.5" "51.5" "50.5" "35.5" "41.8" "50.4" "46.1" "60.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504895740421257345" "False" "High" "IsMasterProtein" "Q9Y4W2" "Ribosomal biogenesis protein LAS1L OS=Homo sapiens OX=9606 GN=LAS1L PE=1 SV=2" "0.000" "False" "17.472" "7" "5" "6" "5" "734" "83.0" "4.73" "18.88" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04031" "81887" "ENSG00000001497" "LAS1L" "A9X410; hsa:81887; Q5JXQ0; Q8TEN5; Q9H9V5; Q9Y4W2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.030" "0.768" "1.177" "1.130" "0.766" "1.193" "1.203" "0.636" "0.974" "99.5" "102.5" "76.4" "117.1" "112.5" "76.3" "118.7" "119.7" "63.3" "96.9" "" "" "" "" "" "" "" "" "" "" "99.5" "86.7" "48.3" "85.4" "92.2" "59.2" "91.5" "103.0" "49.4" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "17.471" "12" "3" "4" "3" "290" "32.3" "5.14" "14.28" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "1.090" "0.956" "1.092" "1.158" "1.088" "1.085" "1.166" "1.000" "1.053" "106.9" "116.4" "102.1" "116.7" "123.8" "116.2" "116.0" "124.6" "106.9" "112.5" "" "" "" "" "" "" "" "" "" "" "106.9" "98.5" "64.6" "85.1" "101.4" "90.3" "89.4" "107.2" "83.4" "101.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "17.468" "8" "4" "5" "4" "727" "79.4" "6.23" "17.45" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "0.942" "0.885" "0.883" "1.035" "0.924" "0.964" "0.974" "0.941" "1.022" "237.5" "223.8" "210.2" "209.8" "245.9" "219.6" "229.0" "231.4" "223.6" "242.7" "" "" "" "" "" "" "" "" "" "" "237.5" "189.3" "132.9" "153.0" "201.5" "170.5" "176.5" "199.0" "174.6" "218.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "17.464" "7" "3" "5" "3" "535" "59.8" "5.08" "16.46" "3" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "" "Nuclear Receptor transcription pathway" "1" "0" "1.172" "0.969" "1.087" "1.203" "1.180" "1.093" "1.152" "1.040" "1.152" "118.0" "138.4" "114.4" "128.3" "142.0" "139.3" "129.0" "136.0" "122.8" "135.9" "" "" "" "" "" "" "" "" "" "" "118.0" "117.1" "72.4" "93.5" "116.3" "108.2" "99.4" "116.9" "95.8" "122.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "17.452" "30" "3" "6" "3" "174" "19.1" "5.05" "20.98" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "" "Purine catabolism" "1" "0" "0.945" "0.978" "1.183" "1.042" "1.005" "1.021" "1.002" "1.011" "1.180" "128.5" "121.5" "125.7" "152.0" "133.9" "129.1" "131.2" "128.7" "129.9" "151.7" "" "" "" "" "" "" "" "" "" "" "128.5" "102.8" "79.5" "110.9" "109.7" "100.3" "101.1" "110.7" "101.4" "136.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3974339187776743055" "False" "High" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "0.000" "False" "17.446" "2" "4" "4" "4" "2177" "242.9" "7.05" "14.95" "4" "cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "1.151" "0.864" "1.078" "1.027" "0.929" "1.113" "1.112" "0.871" "1.038" "61.1" "70.3" "52.8" "65.9" "62.7" "56.8" "68.0" "67.9" "53.2" "63.5" "" "" "" "" "" "" "" "" "" "" "61.1" "59.5" "33.4" "48.0" "51.4" "44.1" "52.4" "58.4" "41.5" "57.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "17.435" "14" "5" "5" "5" "372" "40.5" "6.25" "15.25" "5" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.977" "1.305" "1.008" "0.885" "1.257" "0.957" "0.936" "1.385" "1.084" "211.5" "206.7" "276.1" "213.2" "187.2" "265.9" "202.3" "197.9" "292.9" "229.3" "" "" "" "" "" "" "" "" "" "" "211.5" "174.9" "174.6" "155.4" "153.4" "206.5" "156.0" "170.2" "228.6" "206.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "17.431" "18" "2" "3" "2" "153" "17.2" "8.22" "12.87" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.893" "0.759" "0.974" "0.855" "0.906" "0.953" "1.001" "0.888" "1.031" "88.9" "79.3" "67.5" "86.6" "76.0" "80.5" "84.7" "88.9" "78.9" "91.6" "" "" "" "" "" "" "" "" "" "" "88.9" "67.1" "42.7" "63.1" "62.2" "62.6" "65.3" "76.5" "61.6" "82.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962045687038046175" "False" "High" "IsMasterProtein" "Q8NEC7" "Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens OX=9606 GN=GSTCD PE=1 SV=2" "0.000" "False" "17.425" "9" "5" "6" "5" "633" "71.0" "7.78" "18.40" "5" "" "other cell component" "other molecular function" "Pf13679" "79807" "ENSG00000138780" "GSTCD" "A8K8J0; A8MVD3; H9KV97; hsa:79807; Q8NEC7; Q9H8S3" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.109" "0.825" "1.391" "1.080" "0.951" "1.125" "0.969" "0.828" "1.020" "95.1" "105.5" "78.5" "132.3" "102.7" "90.5" "107.0" "92.1" "78.8" "97.0" "" "" "" "" "" "" "" "" "" "" "95.1" "89.2" "49.6" "96.4" "84.1" "70.3" "82.5" "79.2" "61.5" "87.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "17.405" "6" "5" "5" "5" "879" "100.4" "8.22" "15.94" "5" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "2" "0" "1.048" "0.831" "1.125" "0.939" "0.928" "1.026" "0.952" "0.864" "0.928" "158.0" "165.6" "131.3" "177.7" "148.3" "146.7" "162.2" "150.4" "136.6" "146.7" "" "" "" "" "" "" "" "" "" "" "158.0" "140.1" "83.0" "129.6" "121.5" "113.9" "125.0" "129.3" "106.6" "131.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8789508812130398643" "False" "High" "IsMasterProtein" "Q9BTE7" "DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1" "0.000" "False" "17.398" "22" "5" "6" "5" "237" "27.5" "5.58" "18.11" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03556" "84259" "ENSG00000137692" "DCUN1D5" "hsa:84259; Q3ZTT2; Q9BTE7" "" "Neddylation" "1" "0" "0.891" "0.791" "0.904" "0.891" "0.753" "0.880" "0.960" "0.807" "0.929" "425.7" "379.2" "336.8" "384.9" "379.3" "320.4" "374.8" "408.7" "343.5" "395.7" "" "" "" "" "" "" "" "" "" "" "425.7" "320.8" "213.0" "280.6" "310.7" "248.8" "288.9" "351.4" "268.1" "355.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "17.396" "19" "4" "4" "4" "279" "29.3" "8.57" "15.72" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.053" "1.005" "1.028" "1.060" "0.815" "0.927" "0.976" "0.873" "1.051" "77.3" "81.4" "77.7" "79.4" "81.9" "63.0" "71.6" "75.4" "67.5" "81.3" "" "" "" "" "" "" "" "" "" "" "77.3" "68.8" "49.1" "57.9" "67.1" "48.9" "55.2" "64.9" "52.7" "73.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "174890582361542950" "False" "High" "IsMasterProtein" "Q03052" "POU domain, class 3, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU3F1 PE=1 SV=3" "0.000" "False" "17.395" "8" "3" "3" "3" "451" "45.5" "7.74" "12.10" "3" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5453" "ENSG00000185668" "POU3F1" "hsa:5453; Q03052; Q5TAG2" "" "Formation of the anterior neural plate; Formation of the posterior neural plate; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "3" "0" "0.879" "0.760" "0.946" "0.936" "0.802" "0.923" "0.899" "0.894" "0.883" "84.5" "74.2" "64.2" "79.9" "79.0" "67.7" "78.0" "76.0" "75.5" "74.6" "" "" "" "" "" "" "" "" "" "" "84.5" "62.8" "40.6" "58.3" "64.8" "52.6" "60.1" "65.3" "59.0" "67.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772258242304102193" "False" "High" "IsMasterProtein" "Q9BQE5" "Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=2" "0.000" "False" "17.392" "15" "6" "6" "6" "337" "37.1" "6.74" "20.45" "6" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf05461" "23780" "ENSG00000128335" "APOL2" "B0QYK7; hsa:23780; O95915; Q59GW9; Q5TH96; Q969T6; Q9BQE5; Q9BT28; Q9UGT1; Q9UH10" "" "" "0" "0" "0.932" "0.926" "0.945" "0.942" "0.948" "0.971" "0.964" "0.939" "0.954" "558.2" "520.0" "516.6" "527.7" "525.6" "529.0" "542.2" "538.1" "524.3" "532.6" "" "" "" "" "" "" "" "" "" "" "558.2" "439.9" "326.7" "384.8" "430.6" "410.8" "417.9" "462.7" "409.2" "478.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "17.380" "35" "5" "14" "1" "126" "13.9" "10.32" "38.73" "5" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "" "Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "44" "3" "1.120" "1.138" "1.100" "1.137" "1.188" "1.099" "1.056" "1.123" "1.102" "682.4" "764.0" "776.7" "750.7" "775.8" "810.9" "749.7" "720.8" "766.4" "752.1" "" "" "" "" "" "" "" "" "" "" "682.4" "646.4" "491.1" "547.4" "635.6" "629.7" "577.9" "619.8" "598.2" "676.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874507189654450183" "False" "High" "IsMasterProtein" "P50542" "Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3" "0.000" "False" "17.360" "7" "4" "6" "4" "639" "70.8" "4.54" "17.08" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13181" "5830" "ENSG00000139197; ENSG00000288217" "PEX5" "A8K891; B4DZ45; B7ZAD5; D3DUT8; hsa:5830; P50542; Q15115; Q15266; Q96FN7" "1p36 copy number variation syndrome" "Pexophagy" "2" "0" "1.011" "0.850" "1.080" "0.990" "0.863" "1.072" "1.026" "0.867" "0.910" "319.2" "322.6" "271.2" "344.7" "316.0" "275.5" "342.1" "327.3" "276.8" "290.5" "" "" "" "" "" "" "" "" "" "" "319.2" "272.9" "171.5" "251.3" "258.9" "214.0" "263.7" "281.4" "216.1" "261.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "17.340" "20" "3" "5" "3" "154" "17.3" "6.33" "17.00" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.803" "1.037" "0.914" "0.886" "0.984" "0.957" "0.898" "0.966" "0.909" "334.1" "268.3" "346.6" "305.2" "295.9" "328.7" "319.7" "299.9" "322.9" "303.7" "" "" "" "" "" "" "" "" "" "" "334.1" "227.0" "219.2" "222.5" "242.4" "255.3" "246.4" "257.9" "252.0" "273.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "High" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.000" "False" "17.330" "6" "4" "4" "4" "624" "70.4" "7.78" "13.28" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "1.036" "0.816" "1.015" "1.058" "0.848" "0.967" "1.078" "0.805" "1.021" "386.9" "400.9" "315.8" "392.6" "409.5" "327.9" "374.1" "417.0" "311.5" "395.1" "" "" "" "" "" "" "" "" "" "" "386.9" "339.2" "199.7" "286.3" "335.5" "254.6" "288.4" "358.5" "243.2" "355.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "17.326" "21" "4" "7" "4" "203" "23.2" "7.88" "21.66" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "Metabolism of folate and pterines" "4" "0" "0.977" "0.987" "0.948" "0.992" "1.083" "0.942" "1.004" "1.005" "0.987" "287.1" "280.7" "283.3" "272.1" "284.7" "310.8" "270.3" "288.1" "288.6" "283.3" "" "" "" "" "" "" "" "" "" "" "287.1" "237.4" "179.2" "198.4" "233.3" "241.4" "208.4" "247.7" "225.3" "254.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "17.318" "47" "4" "4" "4" "97" "10.9" "9.41" "15.48" "4" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "1.040" "1.124" "0.917" "1.039" "1.143" "1.125" "0.989" "1.157" "1.050" "299.7" "311.6" "337.0" "274.9" "311.5" "342.4" "337.0" "296.2" "346.8" "314.5" "" "" "" "" "" "" "" "" "" "" "299.7" "263.6" "213.1" "200.4" "255.2" "265.9" "259.8" "254.7" "270.7" "282.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "17.307" "19" "4" "9" "4" "194" "22.1" "10.10" "27.16" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "20" "0" "0.911" "1.192" "0.941" "1.048" "1.162" "1.003" "1.132" "1.160" "1.035" "727.7" "663.0" "867.1" "685.1" "762.9" "845.6" "730.0" "823.8" "844.3" "753.1" "" "" "" "" "" "" "" "" "" "" "727.7" "560.9" "548.3" "499.5" "625.0" "656.6" "562.7" "708.3" "659.0" "677.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "17.283" "14" "7" "7" "7" "403" "46.1" "10.18" "21.84" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.927" "1.417" "1.102" "1.124" "1.348" "1.155" "1.410" "1.375" "1.051" "620.3" "575.1" "878.9" "683.4" "697.5" "836.3" "716.5" "874.3" "853.0" "651.6" "" "" "" "" "" "" "" "" "" "" "620.3" "486.5" "555.7" "498.3" "571.4" "649.4" "552.3" "751.8" "665.9" "585.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "High" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.000" "False" "17.265" "7" "3" "5" "3" "475" "54.8" "4.91" "18.92" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.988" "1.130" "1.219" "0.956" "0.876" "1.123" "1.109" "0.959" "0.960" "73.4" "72.5" "82.9" "89.5" "70.2" "64.3" "82.4" "81.4" "70.4" "70.5" "" "" "" "" "" "" "" "" "" "" "73.4" "61.4" "52.4" "65.3" "57.5" "50.0" "63.6" "70.0" "54.9" "63.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "17.223" "14" "3" "6" "3" "257" "26.9" "11.15" "23.81" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "" "mRNA Splicing - Major Pathway; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.021" "2.377" "1.144" "1.037" "2.009" "0.929" "0.926" "2.128" "1.288" "124.5" "127.2" "296.0" "142.4" "129.1" "250.2" "115.7" "115.3" "265.0" "160.3" "" "" "" "" "" "" "" "" "" "" "124.5" "107.6" "187.2" "103.9" "105.8" "194.3" "89.2" "99.1" "206.8" "144.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "17.223" "4" "7" "7" "7" "1922" "218.5" "5.68" "20.38" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "11" "0" "1.015" "0.847" "1.094" "1.059" "0.954" "1.045" "1.031" "0.899" "0.971" "363.6" "368.9" "307.8" "397.9" "384.9" "346.8" "379.8" "374.8" "326.9" "353.1" "" "" "" "" "" "" "" "" "" "" "363.6" "312.1" "194.6" "290.1" "315.4" "269.3" "292.8" "322.2" "255.2" "317.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.000" "False" "17.222" "8" "3" "4" "3" "522" "58.5" "6.55" "13.67" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.891" "0.737" "0.875" "0.889" "0.731" "0.873" "0.950" "0.761" "0.915" "218.7" "194.8" "161.3" "191.4" "194.5" "159.9" "190.9" "207.7" "166.4" "200.2" "" "" "" "" "" "" "" "" "" "" "218.7" "164.8" "102.0" "139.5" "159.3" "124.2" "147.1" "178.6" "129.9" "180.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7849372490440627698" "False" "High" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "0.000" "False" "17.202" "11" "3" "4" "3" "312" "35.7" "7.55" "10.57" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "4.452" "0.828" "2.029" "2.144" "2.076" "1.706" "1.036" "2.054" "1.667" "33.6" "149.6" "27.8" "68.2" "72.1" "69.8" "57.3" "34.8" "69.0" "56.0" "" "" "" "" "" "" "" "" "" "" "33.6" "126.6" "17.6" "49.7" "59.1" "54.2" "44.2" "29.9" "53.9" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "17.178" "4" "5" "5" "5" "1053" "117.6" "5.86" "16.65" "5" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "Vitamin D receptor pathway" "" "1" "0" "1.008" "1.094" "1.059" "1.025" "1.109" "1.051" "1.112" "1.064" "0.923" "122.7" "123.7" "134.2" "129.9" "125.8" "136.0" "128.9" "136.4" "130.6" "113.3" "" "" "" "" "" "" "" "" "" "" "122.7" "104.7" "84.8" "94.7" "103.0" "105.7" "99.4" "117.3" "101.9" "101.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "17.169" "23" "2" "9" "2" "95" "10.9" "5.50" "35.34" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "TAR syndrome" "SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "15" "0" "0.949" "0.976" "0.986" "0.966" "1.071" "1.140" "0.937" "0.968" "0.922" "994.0" "943.7" "970.3" "980.3" "959.9" "1064.2" "1132.9" "931.6" "962.1" "916.8" "" "" "" "" "" "" "" "" "" "" "994.0" "798.4" "613.5" "714.8" "786.5" "826.4" "873.3" "801.0" "751.0" "824.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "17.166" "13" "5" "5" "5" "432" "51.4" "9.79" "14.30" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.006" "1.151" "1.034" "0.960" "1.137" "0.974" "1.011" "1.101" "1.033" "222.8" "224.0" "256.4" "230.3" "214.0" "253.3" "217.0" "225.2" "245.2" "230.0" "" "" "" "" "" "" "" "" "" "" "222.8" "189.5" "162.1" "167.9" "175.3" "196.7" "167.3" "193.7" "191.4" "206.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "17.149" "5" "6" "7" "6" "1729" "181.7" "4.86" "20.32" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "0.970" "1.123" "0.971" "1.077" "1.113" "1.262" "1.087" "1.164" "1.070" "176.3" "171.0" "198.1" "171.1" "189.9" "196.2" "222.6" "191.7" "205.3" "188.7" "" "" "" "" "" "" "" "" "" "" "176.3" "144.6" "125.2" "124.8" "155.6" "152.4" "171.6" "164.8" "160.2" "169.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "17.146" "11" "3" "3" "3" "460" "52.3" "7.34" "11.95" "3" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "Vasopressin-regulated water reabsorption" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.016" "0.766" "1.776" "1.054" "0.831" "1.051" "1.038" "1.092" "1.270" "14.9" "15.1" "11.4" "26.4" "15.7" "12.3" "15.6" "15.4" "16.2" "18.9" "" "" "" "" "" "" "" "" "" "" "14.9" "12.8" "7.2" "19.2" "12.8" "9.6" "12.0" "13.3" "12.7" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "17.141" "8" "4" "6" "1" "611" "66.7" "7.36" "18.57" "4" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "Bicarbonate transporters" "4" "0" "0.884" "1.001" "0.937" "1.123" "0.957" "0.973" "1.022" "1.191" "1.191" "68.5" "60.5" "68.5" "64.2" "76.9" "65.5" "66.6" "70.0" "81.6" "81.6" "" "" "" "" "" "" "" "" "" "" "68.5" "51.2" "43.3" "46.8" "63.0" "50.9" "51.4" "60.1" "63.7" "73.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "17.128" "13" "4" "5" "4" "336" "38.3" "4.98" "17.57" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "7" "0" "1.270" "1.080" "1.183" "1.150" "1.147" "1.229" "1.046" "1.061" "1.075" "208.8" "265.2" "225.4" "247.0" "240.0" "239.5" "256.5" "218.4" "221.5" "224.5" "" "" "" "" "" "" "" "" "" "" "208.8" "224.4" "142.5" "180.1" "196.7" "186.0" "197.7" "187.8" "172.9" "201.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "17.120" "12" "4" "5" "4" "418" "46.9" "6.93" "12.71" "4" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "0" "1.132" "1.064" "1.112" "1.243" "1.004" "1.209" "1.345" "1.233" "1.194" "33.1" "37.4" "35.2" "36.8" "41.1" "33.2" "39.9" "44.4" "40.8" "39.5" "" "" "" "" "" "" "" "" "" "" "33.1" "31.6" "22.2" "26.8" "33.7" "25.8" "30.8" "38.2" "31.8" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "17.112" "6" "3" "5" "3" "494" "55.0" "7.12" "16.39" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Formation of the active cofactor, UDP-glucuronate" "3" "0" "1.014" "0.835" "1.048" "1.028" "0.935" "1.002" "0.996" "0.974" "1.085" "286.1" "290.0" "239.0" "299.7" "294.1" "267.4" "286.8" "285.0" "278.7" "310.4" "" "" "" "" "" "" "" "" "" "" "286.1" "245.4" "151.1" "218.6" "241.0" "207.6" "221.1" "245.0" "217.5" "279.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "17.101" "19" "3" "13" "3" "144" "16.5" "5.24" "42.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "8" "0" "0.946" "1.083" "0.904" "0.977" "1.094" "1.044" "1.021" "1.064" "1.057" "775.1" "733.1" "839.2" "700.9" "757.2" "847.7" "808.9" "791.6" "824.9" "819.3" "" "" "" "" "" "" "" "" "" "" "775.1" "620.3" "530.7" "511.1" "620.4" "658.3" "623.5" "680.6" "643.8" "736.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "17.088" "34" "5" "6" "5" "154" "17.5" "6.11" "20.07" "5" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.960" "0.910" "1.000" "1.143" "0.900" "1.324" "0.924" "0.908" "0.970" "95.9" "92.1" "87.3" "95.9" "109.7" "86.3" "127.1" "88.7" "87.1" "93.1" "" "" "" "" "" "" "" "" "" "" "95.9" "77.9" "55.2" "69.9" "89.8" "67.0" "97.9" "76.2" "68.0" "83.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9176436912319366181" "False" "High" "IsMasterProtein" "Q9Y5Q9" "General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1" "0.000" "False" "17.082" "5" "4" "4" "4" "886" "101.2" "5.07" "13.81" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13181" "9330" "ENSG00000119041" "GTF3C3" "hsa:9330; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97; Q9Y5Q9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.940" "0.646" "0.886" "1.060" "0.675" "0.982" "0.936" "0.674" "0.787" "271.2" "254.9" "175.2" "240.2" "287.3" "183.2" "266.3" "253.7" "182.7" "213.3" "" "" "" "" "" "" "" "" "" "" "271.2" "215.7" "110.8" "175.2" "235.4" "142.2" "205.3" "218.2" "142.6" "191.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "17.069" "17" "4" "7" "4" "248" "29.2" "10.65" "25.52" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.887" "1.375" "1.133" "1.058" "1.487" "1.177" "1.273" "1.553" "1.228" "245.4" "217.6" "337.4" "278.1" "259.7" "364.9" "288.8" "312.3" "381.0" "301.2" "" "" "" "" "" "" "" "" "" "" "245.4" "184.1" "213.3" "202.7" "212.8" "283.4" "222.6" "268.5" "297.4" "270.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.000" "False" "17.065" "2" "6" "6" "6" "3546" "404.0" "5.82" "17.15" "6" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "2" "0" "1.032" "0.893" "0.956" "1.020" "0.813" "0.992" "0.975" "0.845" "1.012" "177.9" "183.6" "158.8" "170.1" "181.4" "144.7" "176.4" "173.4" "150.3" "179.9" "" "" "" "" "" "" "" "" "" "" "177.9" "155.3" "100.4" "124.0" "148.6" "112.3" "136.0" "149.1" "117.3" "161.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1155650016836113983" "False" "High" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "0.000" "False" "17.060" "7" "2" "3" "2" "403" "46.4" "8.69" "10.70" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "1.085" "0.893" "1.249" "1.104" "1.050" "1.042" "1.057" "0.994" "1.192" "49.6" "53.8" "44.3" "61.9" "54.7" "52.0" "51.6" "52.4" "49.3" "59.1" "" "" "" "" "" "" "" "" "" "" "49.6" "45.5" "28.0" "45.1" "44.8" "40.4" "39.8" "45.0" "38.5" "53.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "17.048" "3" "6" "7" "6" "1944" "216.4" "6.30" "20.84" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Cell cycle; 2q13 copy number variation syndrome" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.123" "0.882" "1.098" "1.100" "0.901" "1.143" "1.141" "0.844" "0.941" "327.9" "368.2" "289.3" "360.2" "360.8" "295.3" "374.8" "374.2" "276.8" "308.7" "" "" "" "" "" "" "" "" "" "" "327.9" "311.5" "182.9" "262.6" "295.6" "229.3" "288.9" "321.7" "216.1" "277.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "17.004" "12" "5" "6" "5" "425" "48.0" "4.81" "17.52" "5" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.974" "0.828" "1.008" "1.147" "0.967" "0.994" "0.980" "0.906" "0.969" "133.1" "129.7" "110.3" "134.2" "152.7" "128.7" "132.3" "130.4" "120.6" "129.0" "" "" "" "" "" "" "" "" "" "" "133.1" "109.7" "69.7" "97.8" "125.1" "100.0" "102.0" "112.1" "94.1" "116.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "16.994" "12" "3" "4" "3" "272" "31.4" "5.91" "13.72" "3" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "Ciliary landscape" "" "1" "0" "0.992" "0.986" "1.006" "1.116" "1.021" "1.006" "1.126" "1.011" "0.935" "82.9" "82.3" "81.8" "83.4" "92.6" "84.6" "83.4" "93.4" "83.8" "77.5" "" "" "" "" "" "" "" "" "" "" "82.9" "69.6" "51.7" "60.8" "75.8" "65.7" "64.3" "80.3" "65.4" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "343969761747531800" "False" "High" "IsMasterProtein" "Q9C0G0" "Zinc finger protein 407 OS=Homo sapiens OX=9606 GN=ZNF407 PE=1 SV=2" "0.000" "False" "16.967" "2" "4" "4" "4" "2248" "247.2" "6.49" "13.31" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "55628" "ENSG00000215421" "ZNF407" "B5MD54; hsa:55628; Q96MY0; Q9C0G0; Q9H8A1; Q9NXD4; Q9NXD7" "" "" "0" "0" "1.052" "0.777" "1.048" "1.152" "0.700" "1.000" "1.068" "0.823" "0.853" "138.8" "146.0" "107.8" "145.5" "159.9" "97.2" "138.9" "148.3" "114.2" "118.3" "" "" "" "" "" "" "" "" "" "" "138.8" "123.5" "68.2" "106.1" "131.0" "75.5" "107.0" "127.5" "89.2" "106.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "16.961" "12" "4" "4" "4" "472" "53.8" "5.80" "12.39" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.465" "0.996" "1.215" "1.413" "1.284" "1.216" "1.297" "1.333" "1.195" "29.1" "42.6" "28.9" "35.3" "41.1" "37.3" "35.3" "37.7" "38.7" "34.7" "" "" "" "" "" "" "" "" "" "" "29.1" "36.0" "18.3" "25.7" "33.6" "29.0" "27.2" "32.4" "30.2" "31.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7705626466042458302" "False" "High" "IsMasterProtein" "O75191" "Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3" "0.000" "False" "16.943" "8" "4" "5" "4" "536" "58.3" "5.86" "18.98" "4" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00370, Pf02782" "9942" "ENSG00000093217" "XYLB" "B2RAW4; B4DDT2; B9EH64; hsa:9942; O75191" "" "Formation of xylulose-5-phosphate" "1" "0" "0.872" "0.999" "0.972" "0.972" "1.071" "0.986" "1.124" "1.020" "1.144" "123.3" "107.6" "123.2" "119.9" "119.9" "132.0" "121.6" "138.6" "125.7" "141.1" "" "" "" "" "" "" "" "" "" "" "123.3" "91.0" "77.9" "87.4" "98.2" "102.5" "93.7" "119.2" "98.1" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "16.938" "6" "3" "4" "3" "525" "58.1" "5.07" "13.83" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "EGF/EGFR signaling pathway" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "9" "0" "1.122" "1.114" "1.001" "1.100" "1.196" "1.181" "1.017" "1.171" "0.946" "120.7" "135.5" "134.5" "120.8" "132.8" "144.3" "142.5" "122.8" "141.3" "114.2" "" "" "" "" "" "" "" "" "" "" "120.7" "114.6" "85.0" "88.1" "108.8" "112.1" "109.8" "105.6" "110.3" "102.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "16.913" "12" "4" "6" "3" "467" "52.3" "6.58" "17.91" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "49" "0" "1.026" "1.016" "1.081" "1.001" "0.699" "1.032" "1.014" "0.910" "0.872" "138.7" "142.3" "140.8" "149.9" "138.8" "97.0" "143.1" "140.7" "126.2" "120.9" "" "" "" "" "" "" "" "" "" "" "138.7" "120.4" "89.1" "109.3" "113.8" "75.3" "110.3" "120.9" "98.5" "108.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "16.886" "12" "5" "9" "5" "369" "39.1" "6.30" "27.20" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "0.934" "1.029" "1.001" "1.022" "0.919" "0.992" "0.966" "0.975" "0.993" "532.8" "497.6" "548.5" "533.4" "544.4" "489.8" "528.6" "514.7" "519.3" "528.9" "" "" "" "" "" "" "" "" "" "" "532.8" "421.0" "346.8" "389.0" "446.0" "380.4" "407.5" "442.5" "405.4" "475.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.000" "False" "16.879" "11" "5" "6" "4" "429" "46.8" "8.87" "19.22" "5" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "0.988" "0.992" "1.097" "1.106" "1.035" "1.061" "1.129" "1.010" "0.977" "255.2" "252.3" "253.1" "279.9" "282.3" "264.1" "270.7" "288.2" "257.7" "249.3" "" "" "" "" "" "" "" "" "" "" "255.2" "213.4" "160.0" "204.1" "231.3" "205.1" "208.7" "247.8" "201.1" "224.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "16.879" "7" "4" "8" "4" "479" "53.5" "4.81" "24.39" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Translation factors" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "4" "0" "1.009" "0.996" "1.046" "0.975" "0.955" "0.930" "0.993" "1.033" "1.011" "343.0" "345.9" "341.6" "358.8" "334.6" "327.5" "319.0" "340.7" "354.3" "346.9" "" "" "" "" "" "" "" "" "" "" "343.0" "292.7" "216.0" "261.6" "274.1" "254.3" "245.9" "292.9" "276.6" "311.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585419871706527859" "False" "High" "IsMasterProtein" "Q8TDY2" "RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3" "0.000" "False" "16.877" "3" "5" "5" "5" "1594" "183.0" "5.41" "14.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10377" "9821" "ENSG00000023287" "RB1CC1" "hsa:9821; Q86YR4; Q8TDY2; Q8WVU9; Q92601" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "11" "0" "1.042" "0.983" "1.104" "1.149" "1.058" "1.136" "1.129" "0.951" "1.067" "349.6" "364.1" "343.4" "385.9" "401.6" "369.7" "396.9" "394.5" "332.5" "372.9" "" "" "" "" "" "" "" "" "" "" "349.6" "308.1" "217.2" "281.4" "329.0" "287.1" "306.0" "339.2" "259.5" "335.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "16.872" "6" "5" "5" "5" "654" "74.3" "6.89" "17.76" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "0.986" "0.905" "0.959" "0.959" "0.903" "0.984" "1.032" "0.933" "0.973" "395.7" "390.4" "358.2" "379.6" "379.4" "357.5" "389.3" "408.5" "369.3" "385.2" "" "" "" "" "" "" "" "" "" "" "395.7" "330.3" "226.5" "276.8" "310.9" "277.6" "300.1" "351.2" "288.2" "346.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "16.868" "14" "2" "6" "2" "194" "21.4" "5.66" "13.38" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "" "Purine catabolism; Ribavirin ADME" "2" "0" "0.992" "0.908" "0.983" "0.914" "1.097" "0.966" "0.964" "0.893" "0.965" "186.1" "184.6" "168.9" "182.9" "170.1" "204.0" "179.7" "179.3" "166.2" "179.5" "" "" "" "" "" "" "" "" "" "" "186.1" "156.2" "106.8" "133.3" "139.4" "158.5" "138.5" "154.2" "129.7" "161.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.000" "False" "16.864" "13" "6" "7" "6" "423" "47.8" "8.73" "19.10" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Mitochondrial protein degradation; Heme biosynthesis" "4" "0" "1.093" "0.856" "0.991" "0.900" "0.950" "1.471" "0.915" "1.242" "1.098" "20.0" "21.9" "17.1" "19.8" "18.0" "19.0" "29.4" "18.3" "24.8" "22.0" "" "" "" "" "" "" "" "" "" "" "20.0" "18.5" "10.8" "14.5" "14.7" "14.7" "22.7" "15.7" "19.4" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "16.856" "24" "3" "4" "3" "205" "23.4" "7.62" "15.30" "3" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "" "Mitochondrial protein import" "1" "0" "0.997" "0.992" "1.085" "1.044" "1.016" "1.308" "1.064" "1.042" "1.108" "36.3" "36.2" "36.0" "39.4" "37.9" "36.8" "47.4" "38.6" "37.8" "40.2" "" "" "" "" "" "" "" "" "" "" "36.3" "30.6" "22.7" "28.7" "31.0" "28.6" "36.6" "33.2" "29.5" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "16.852" "13" "5" "5" "3" "377" "42.8" "6.47" "16.40" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Activation of RAC1" "27" "0" "0.843" "0.747" "1.194" "1.149" "0.765" "0.802" "1.277" "0.846" "0.889" "34.1" "28.7" "25.5" "40.7" "39.1" "26.1" "27.3" "43.5" "28.8" "30.3" "" "" "" "" "" "" "" "" "" "" "34.1" "24.3" "16.1" "29.7" "32.1" "20.2" "21.1" "37.4" "22.5" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "16.836" "14" "7" "8" "4" "422" "46.1" "5.10" "22.74" "7" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "2" "0.975" "0.774" "0.957" "0.937" "0.779" "0.880" "0.934" "0.768" "0.888" "636.6" "620.5" "492.6" "609.4" "596.5" "495.6" "560.0" "594.6" "489.2" "565.4" "" "" "" "" "" "" "" "" "" "" "636.6" "525.0" "311.5" "444.4" "488.7" "384.9" "431.7" "511.2" "381.8" "508.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "16.831" "14" "5" "5" "5" "470" "53.9" "5.80" "14.11" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "1.076" "1.105" "0.998" "0.994" "1.020" "1.063" "1.111" "1.043" "1.081" "81.8" "88.0" "90.4" "81.6" "81.3" "83.4" "86.9" "90.8" "85.3" "88.4" "" "" "" "" "" "" "" "" "" "" "81.8" "74.4" "57.1" "59.5" "66.6" "64.7" "67.0" "78.1" "66.6" "79.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.000" "False" "16.830" "8" "4" "4" "4" "613" "67.1" "6.55" "14.39" "4" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "0.890" "0.851" "1.081" "1.029" "0.823" "1.115" "0.982" "0.795" "0.923" "349.2" "310.8" "297.1" "377.3" "359.4" "287.3" "389.1" "342.8" "277.5" "322.3" "" "" "" "" "" "" "" "" "" "" "349.2" "263.0" "187.8" "275.1" "294.4" "223.1" "300.0" "294.7" "216.6" "289.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100821946699504428" "False" "High" "IsMasterProtein" "Q5QNW6" "Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3" "0.000" "False" "16.819" "35" "5" "14" "1" "126" "13.9" "10.32" "39.07" "5" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "440689" "ENSG00000203814" "H2BC18" "A8K0U9; B4DLA9; hsa:440689; Q5QNW6" "" "HCMV Late Events; HCMV Early Events; Ub-specific processing proteases; HDACs deacetylate histones; HATs acetylate histones" "5" "0" "0.871" "0.895" "0.577" "0.798" "0.949" "0.650" "0.906" "0.930" "1.055" "387.3" "337.4" "346.5" "223.5" "308.9" "367.6" "251.9" "351.0" "360.3" "408.7" "" "" "" "" "" "" "" "" "" "" "387.3" "285.4" "219.1" "162.9" "253.1" "285.4" "194.2" "301.8" "281.2" "367.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.000" "False" "16.815" "8" "3" "3" "3" "531" "59.7" "5.33" "12.07" "3" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "0.970" "0.807" "1.009" "0.936" "0.753" "0.943" "0.993" "0.775" "0.895" "149.4" "144.8" "120.6" "150.7" "139.8" "112.5" "140.8" "148.3" "115.7" "133.7" "" "" "" "" "" "" "" "" "" "" "149.4" "122.5" "76.3" "109.9" "114.5" "87.3" "108.5" "127.5" "90.3" "120.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "16.805" "40" "4" "6" "4" "112" "12.5" "4.78" "18.51" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "22" "0" "0.968" "1.128" "0.915" "1.115" "1.141" "0.935" "0.994" "1.057" "1.017" "261.9" "253.6" "295.3" "239.6" "292.2" "298.9" "245.0" "260.3" "277.0" "266.3" "" "" "" "" "" "" "" "" "" "" "261.9" "214.6" "186.7" "174.7" "239.4" "232.1" "188.8" "223.8" "216.2" "239.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "16.781" "15" "5" "5" "5" "358" "40.6" "5.94" "14.99" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "" "7" "0" "1.099" "1.080" "1.173" "1.072" "1.088" "1.052" "1.035" "1.084" "1.139" "164.3" "180.6" "177.4" "192.8" "176.2" "178.8" "172.9" "170.0" "178.2" "187.1" "" "" "" "" "" "" "" "" "" "" "164.3" "152.8" "112.2" "140.6" "144.4" "138.9" "133.3" "146.2" "139.1" "168.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115702628811982031" "False" "High" "IsMasterProtein" "Q8N5A5" "Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3" "0.000" "False" "16.776" "9" "4" "4" "4" "531" "57.3" "5.43" "14.11" "4" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf18044" "84619" "ENSG00000197114" "ZGPAT" "E1P5K1; hsa:84619; Q4VXN9; Q5JWI9; Q5JWJ0; Q8N5A5; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "16.759" "7" "3" "4" "3" "548" "59.3" "4.58" "13.99" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "2" "0" "1.006" "1.117" "1.001" "1.086" "1.118" "1.097" "1.127" "1.106" "1.075" "171.7" "172.8" "191.8" "171.9" "186.5" "192.0" "188.4" "193.5" "189.9" "184.6" "" "" "" "" "" "" "" "" "" "" "171.7" "146.2" "121.3" "125.3" "152.8" "149.1" "145.2" "166.4" "148.2" "165.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "16.757" "8" "5" "5" "5" "557" "65.6" "6.64" "14.69" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.129" "1.182" "1.082" "1.321" "1.230" "1.236" "1.136" "1.133" "1.096" "68.6" "77.5" "81.1" "74.2" "90.7" "84.4" "84.9" "78.0" "77.7" "75.2" "" "" "" "" "" "" "" "" "" "" "68.6" "65.6" "51.3" "54.1" "74.3" "65.6" "65.4" "67.1" "60.7" "67.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "16.756" "6" "5" "5" "5" "1029" "118.2" "8.47" "16.13" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "" "mRNA Splicing - Major Pathway" "1" "0" "0.920" "0.948" "0.964" "1.024" "1.066" "1.188" "1.106" "0.991" "1.061" "115.1" "105.9" "109.1" "111.0" "117.9" "122.7" "136.7" "127.3" "114.0" "122.1" "" "" "" "" "" "" "" "" "" "" "115.1" "89.6" "69.0" "80.9" "96.6" "95.3" "105.4" "109.4" "89.0" "109.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "16.748" "7" "4" "4" "4" "706" "79.2" "6.44" "11.99" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "Nicotinate metabolism" "3" "0" "1.100" "1.110" "1.338" "1.102" "1.093" "1.181" "0.980" "1.326" "1.110" "109.1" "120.1" "121.1" "146.0" "120.2" "119.3" "128.9" "106.9" "144.7" "121.1" "" "" "" "" "" "" "" "" "" "" "109.1" "101.6" "76.6" "106.4" "98.5" "92.6" "99.3" "91.9" "112.9" "108.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "16.743" "9" "3" "4" "2" "359" "40.6" "4.89" "15.75" "3" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "Initiation of transcription and translation elongation at the HIV-1 LTR" "" "1" "0" "0.986" "0.976" "0.926" "1.025" "1.011" "1.184" "0.929" "0.922" "0.878" "118.8" "117.1" "115.9" "110.0" "121.8" "120.0" "140.6" "110.3" "109.5" "104.2" "" "" "" "" "" "" "" "" "" "" "118.8" "99.1" "73.3" "80.2" "99.8" "93.2" "108.4" "94.8" "85.4" "93.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "16.742" "10" "4" "5" "4" "492" "52.0" "6.48" "18.45" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "" "tRNA modification in the mitochondrion" "1" "0" "1.118" "1.024" "1.129" "1.133" "1.050" "1.081" "1.120" "1.056" "1.104" "175.4" "196.1" "179.6" "198.0" "198.7" "184.2" "189.6" "196.4" "185.1" "193.7" "" "" "" "" "" "" "" "" "" "" "175.4" "165.9" "113.6" "144.4" "162.8" "143.1" "146.2" "168.9" "144.5" "174.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "16.740" "22" "4" "6" "4" "198" "23.0" "7.93" "24.24" "4" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "" "PI Metabolism" "1" "0" "1.022" "1.049" "1.069" "1.050" "1.088" "1.005" "0.975" "1.034" "1.024" "422.0" "431.5" "442.6" "451.3" "443.1" "459.2" "424.1" "411.6" "436.4" "432.0" "" "" "" "" "" "" "" "" "" "" "422.0" "365.0" "279.9" "329.1" "363.0" "356.6" "326.9" "353.9" "340.6" "388.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "High" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.000" "False" "16.731" "2" "6" "6" "6" "3027" "337.6" "6.34" "15.88" "6" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "1.037" "0.775" "1.054" "1.136" "0.937" "1.127" "0.991" "0.985" "1.030" "181.0" "187.6" "140.2" "190.8" "205.6" "169.6" "204.0" "179.3" "178.3" "186.4" "" "" "" "" "" "" "" "" "" "" "181.0" "158.7" "88.7" "139.1" "168.4" "131.7" "157.2" "154.1" "139.1" "167.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-585008616192458607" "False" "High" "IsMasterProtein" "Q9H6E5" "Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Homo sapiens OX=9606 GN=TUT1 PE=1 SV=2" "0.000" "False" "16.722" "6" "5" "6" "5" "874" "93.8" "6.16" "15.75" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf03828, Pf12874" "64852" "ENSG00000149016" "TUT1" "A1A527; A8K995; hsa:64852; Q2NL65; Q7L583; Q9H6E5; Q9H6H7" "" "" "0" "0" "1.059" "0.828" "1.086" "1.066" "0.857" "1.052" "1.089" "0.955" "0.977" "431.1" "456.7" "356.8" "468.4" "459.8" "369.3" "453.6" "469.5" "411.6" "421.2" "" "" "" "" "" "" "" "" "" "" "431.1" "386.4" "225.6" "341.5" "376.7" "286.8" "349.7" "403.7" "321.2" "378.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "16.684" "21" "3" "8" "3" "172" "18.6" "9.51" "22.12" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.137" "1.160" "0.940" "0.994" "1.127" "1.110" "1.007" "1.034" "1.167" "324.9" "369.3" "376.7" "305.5" "322.9" "366.2" "360.6" "327.1" "336.0" "379.0" "" "" "" "" "" "" "" "" "" "" "324.9" "312.4" "238.2" "222.7" "264.6" "284.4" "278.0" "281.3" "262.2" "340.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "16.675" "8" "5" "7" "2" "530" "58.9" "6.89" "19.26" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "12" "1" "1.147" "0.834" "1.216" "1.116" "0.938" "1.061" "1.214" "0.994" "1.073" "182.4" "209.1" "152.1" "221.9" "203.5" "171.2" "193.5" "221.4" "181.3" "195.7" "" "" "" "" "" "" "" "" "" "" "182.4" "176.9" "96.2" "161.8" "166.7" "132.9" "149.1" "190.3" "141.5" "175.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.000" "False" "16.660" "8" "5" "5" "5" "726" "80.9" "8.41" "16.01" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "1.208" "0.986" "1.246" "1.141" "1.129" "1.167" "1.093" "1.114" "1.192" "198.9" "240.3" "196.1" "247.8" "227.0" "224.6" "232.1" "217.4" "221.6" "237.1" "" "" "" "" "" "" "" "" "" "" "198.9" "203.3" "124.0" "180.7" "186.0" "174.4" "178.9" "186.9" "173.0" "213.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "16.640" "39" "5" "7" "5" "110" "12.4" "8.41" "20.67" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.989" "1.060" "0.921" "0.966" "1.080" "1.072" "1.034" "1.059" "0.963" "895.7" "886.1" "949.7" "825.3" "865.2" "967.6" "960.5" "926.4" "948.4" "862.3" "" "" "" "" "" "" "" "" "" "" "895.7" "749.7" "600.5" "601.7" "708.9" "751.4" "740.4" "796.5" "740.3" "775.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "16.635" "11" "4" "8" "4" "391" "44.1" "6.33" "25.94" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "Tumor suppressor activity of SMARCB1" "" "1" "0" "0.980" "0.910" "0.991" "1.059" "0.965" "1.102" "1.065" "0.928" "0.910" "260.6" "255.4" "237.1" "258.4" "276.1" "251.6" "287.3" "277.7" "241.8" "237.1" "" "" "" "" "" "" "" "" "" "" "260.6" "216.1" "149.9" "188.4" "226.2" "195.4" "221.4" "238.7" "188.8" "213.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3461601812333061569" "False" "High" "IsMasterProtein" "Q9NRJ5" "Poly(A) polymerase beta OS=Homo sapiens OX=9606 GN=PAPOLB PE=1 SV=2" "0.000" "False" "16.632" "7" "4" "6" "1" "637" "71.8" "6.44" "17.05" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "56903" "ENSG00000218823" "PAPOLB" "hsa:56903; Q75LH1; Q8NE14; Q9NRJ5" "" "" "0" "0" "1.045" "1.019" "1.168" "1.045" "1.094" "1.091" "1.375" "0.993" "1.082" "54.8" "57.3" "55.8" "64.0" "57.2" "60.0" "59.8" "75.4" "54.4" "59.3" "" "" "" "" "" "" "" "" "" "" "54.8" "48.5" "35.3" "46.6" "46.9" "46.6" "46.1" "64.8" "42.5" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "16.602" "11" "4" "5" "2" "420" "46.7" "8.78" "15.90" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "Regulation of HSF1-mediated heat shock response; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "95" "0" "1.138" "1.501" "1.585" "1.190" "1.437" "1.477" "1.460" "1.087" "1.174" "31.8" "36.2" "47.8" "50.4" "37.8" "45.7" "47.0" "46.4" "34.6" "37.4" "" "" "" "" "" "" "" "" "" "" "31.8" "30.6" "30.2" "36.7" "31.0" "35.5" "36.2" "39.9" "27.0" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2751742477750142499" "False" "High" "IsMasterProtein" "Q15345" "Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3" "0.000" "False" "16.593" "7" "6" "7" "6" "812" "88.6" "8.38" "17.38" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "10489" "ENSG00000132128" "LRRC41" "A8K5G8; hsa:10489; Q15345; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; RHOBTB3 ATPase cycle" "3" "0" "1.082" "0.929" "1.073" "1.044" "0.845" "1.039" "1.079" "0.854" "1.008" "342.0" "370.0" "317.8" "367.1" "357.2" "289.1" "355.4" "369.0" "292.0" "344.7" "" "" "" "" "" "" "" "" "" "" "342.0" "313.0" "200.9" "267.6" "292.6" "224.5" "273.9" "317.2" "227.9" "309.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "16.589" "8" "5" "5" "3" "733" "75.4" "9.32" "17.70" "5" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "" "UCH proteinases" "1" "2" "1.129" "0.824" "1.040" "1.124" "0.847" "0.916" "1.016" "0.900" "1.030" "260.4" "294.1" "214.6" "271.0" "292.7" "220.7" "238.5" "264.7" "234.4" "268.3" "" "" "" "" "" "" "" "" "" "" "260.4" "248.8" "135.7" "197.6" "239.8" "171.4" "183.9" "227.6" "183.0" "241.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "High" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.000" "False" "16.561" "11" "6" "7" "6" "477" "53.2" "8.98" "21.36" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Orexin receptor pathway" "Mitochondrial tRNA aminoacylation" "2" "0" "1.030" "0.836" "1.066" "0.982" "0.870" "0.970" "1.085" "0.904" "0.966" "580.5" "597.9" "485.1" "618.8" "570.1" "505.0" "563.2" "630.0" "524.9" "561.0" "" "" "" "" "" "" "" "" "" "" "580.5" "505.8" "306.7" "451.2" "467.1" "392.2" "434.1" "541.7" "409.7" "504.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.000" "False" "16.530" "10" "3" "3" "3" "474" "53.8" "4.75" "13.40" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Androgen receptor signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.256" "0.732" "0.966" "0.973" "0.716" "0.867" "1.079" "0.835" "0.904" "116.8" "146.8" "85.5" "112.9" "113.7" "83.6" "101.3" "126.1" "97.5" "105.6" "" "" "" "" "" "" "" "" "" "" "116.8" "124.2" "54.1" "82.3" "93.1" "64.9" "78.1" "108.4" "76.1" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "16.528" "3" "4" "5" "4" "1412" "158.2" "5.50" "14.95" "4" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "26" "0" "0.889" "0.969" "0.972" "0.979" "0.948" "0.891" "1.013" "1.046" "0.956" "245.9" "218.7" "238.3" "239.0" "240.7" "233.2" "219.0" "249.1" "257.2" "235.1" "" "" "" "" "" "" "" "" "" "" "245.9" "185.0" "150.7" "174.3" "197.2" "181.1" "168.8" "214.2" "200.8" "211.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "16.526" "5" "4" "4" "4" "962" "106.8" "8.02" "15.43" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.938" "0.928" "1.076" "1.001" "0.943" "1.022" "0.939" "0.896" "1.123" "89.9" "84.3" "83.4" "96.7" "89.9" "84.8" "91.8" "84.4" "80.6" "101.0" "" "" "" "" "" "" "" "" "" "" "89.9" "71.3" "52.8" "70.5" "73.7" "65.8" "70.8" "72.5" "62.9" "90.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "16.523" "13" "4" "5" "4" "304" "33.4" "4.92" "15.98" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "0.956" "0.935" "0.924" "1.065" "1.129" "1.010" "1.024" "0.988" "0.995" "295.3" "282.2" "276.2" "273.0" "314.6" "333.4" "298.2" "302.4" "291.6" "293.9" "" "" "" "" "" "" "" "" "" "" "295.3" "238.8" "174.6" "199.0" "257.8" "258.9" "229.9" "260.0" "227.6" "264.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "16.485" "8" "3" "3" "3" "412" "46.3" "5.11" "11.05" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739336077855480502" "False" "High" "IsMasterProtein" "Q9NWY4" "Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2" "0.000" "False" "16.483" "15" "5" "5" "5" "346" "39.4" "6.80" "16.12" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10228" "54969" "ENSG00000056050" "HPF1" "hsa:54969; Q9NWY4" "" "" "0" "0" "0.993" "0.957" "1.060" "1.040" "1.025" "1.080" "1.043" "0.995" "1.092" "257.2" "255.4" "246.2" "272.8" "267.4" "263.6" "277.7" "268.3" "256.0" "280.9" "" "" "" "" "" "" "" "" "" "" "257.2" "216.1" "155.7" "198.9" "219.1" "204.7" "214.1" "230.7" "199.8" "252.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "16.478" "12" "4" "4" "4" "385" "44.1" "6.23" "13.89" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "8" "0" "1.046" "1.061" "1.026" "1.178" "1.046" "1.056" "1.069" "0.986" "1.026" "168.1" "175.9" "178.3" "172.4" "198.1" "175.9" "177.4" "179.6" "165.7" "172.5" "" "" "" "" "" "" "" "" "" "" "168.1" "148.8" "112.7" "125.7" "162.3" "136.6" "136.8" "154.4" "129.4" "155.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "16.444" "19" "5" "6" "5" "304" "34.3" "9.28" "13.92" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "15q11q13 copy number variation" "SUMOylation of DNA damage response and repair proteins" "2" "0" "1.080" "0.925" "1.084" "1.104" "0.985" "1.035" "1.020" "0.942" "1.162" "345.1" "372.7" "319.4" "374.0" "381.1" "339.8" "357.4" "352.1" "325.2" "401.2" "" "" "" "" "" "" "" "" "" "" "345.1" "315.3" "202.0" "272.7" "312.2" "263.9" "275.5" "302.7" "253.8" "360.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "16.441" "9" "4" "7" "4" "420" "46.3" "7.21" "18.99" "4" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.019" "0.939" "1.061" "1.020" "0.980" "1.128" "1.092" "0.994" "0.995" "356.5" "363.1" "334.9" "378.3" "363.5" "349.4" "402.0" "389.2" "354.3" "354.5" "" "" "" "" "" "" "" "" "" "" "356.5" "307.2" "211.7" "275.8" "297.9" "271.3" "309.9" "334.7" "276.5" "318.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "16.439" "26" "5" "5" "5" "182" "20.5" "6.79" "17.86" "5" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.980" "1.083" "0.952" "0.926" "1.064" "1.003" "0.981" "0.998" "0.985" "631.8" "619.2" "684.4" "601.7" "585.2" "672.4" "634.0" "619.8" "630.7" "622.2" "" "" "" "" "" "" "" "" "" "" "631.8" "523.8" "432.7" "438.7" "479.4" "522.1" "488.7" "532.9" "492.3" "559.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "High" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.000" "False" "16.436" "5" "3" "4" "3" "966" "104.9" "4.87" "9.69" "3" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "1.174" "1.002" "1.169" "1.160" "1.017" "1.032" "1.131" "1.061" "1.136" "159.7" "187.4" "159.9" "186.7" "185.3" "162.4" "164.8" "180.6" "169.4" "181.5" "" "" "" "" "" "" "" "" "" "" "159.7" "158.6" "101.1" "136.1" "151.8" "126.1" "127.0" "155.3" "132.2" "163.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "16.431" "3" "4" "6" "2" "1271" "140.4" "8.29" "16.19" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "0.986" "0.705" "0.996" "1.028" "1.116" "0.863" "1.079" "0.831" "1.022" "50.3" "49.6" "35.5" "50.1" "51.8" "56.1" "43.4" "54.3" "41.8" "51.4" "" "" "" "" "" "" "" "" "" "" "50.3" "42.0" "22.4" "36.5" "42.4" "43.6" "33.5" "46.7" "32.6" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "16.430" "21" "4" "7" "3" "165" "18.5" "7.85" "22.63" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "Androgen receptor signaling pathway" "" "1" "0" "0.887" "0.954" "0.879" "0.881" "0.985" "0.946" "0.929" "0.960" "0.884" "699.9" "620.7" "667.4" "615.0" "616.5" "689.7" "662.1" "650.1" "672.2" "619.0" "" "" "" "" "" "" "" "" "" "" "699.9" "525.1" "422.0" "448.4" "505.1" "535.6" "510.4" "559.0" "524.7" "556.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "16.410" "13" "3" "4" "3" "318" "35.2" "8.94" "15.23" "3" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Pentose phosphate pathway in senescent cells" "Neutrophil degranulation; Pentose phosphate pathway" "3" "0" "1.145" "1.134" "0.914" "1.045" "1.035" "0.986" "1.011" "1.167" "1.131" "143.8" "164.7" "163.1" "131.4" "150.3" "148.9" "141.8" "145.4" "167.9" "162.7" "" "" "" "" "" "" "" "" "" "" "143.8" "139.3" "103.1" "95.8" "123.2" "115.7" "109.3" "125.0" "131.1" "146.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.000" "False" "16.389" "7" "3" "3" "3" "459" "51.7" "5.44" "12.28" "3" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "0.968" "0.870" "1.104" "1.054" "0.884" "1.063" "1.090" "0.853" "0.830" "303.8" "294.1" "264.2" "335.3" "320.2" "268.5" "322.8" "331.2" "259.1" "252.1" "" "" "" "" "" "" "" "" "" "" "303.8" "248.8" "167.1" "244.5" "262.3" "208.5" "248.8" "284.8" "202.2" "226.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "16.376" "7" "4" "5" "4" "707" "78.5" "4.87" "14.87" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "0.851" "1.019" "1.002" "0.886" "0.943" "1.008" "0.841" "0.818" "0.966" "170.7" "145.2" "173.8" "171.0" "151.1" "160.9" "172.0" "143.4" "139.7" "164.9" "" "" "" "" "" "" "" "" "" "" "170.7" "122.9" "109.9" "124.7" "123.8" "125.0" "132.6" "123.3" "109.0" "148.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "16.367" "16" "2" "7" "2" "143" "14.8" "8.63" "23.04" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.022" "0.997" "0.977" "1.104" "1.033" "1.175" "1.065" "0.921" "0.975" "136.4" "139.4" "135.9" "133.3" "150.6" "141.0" "160.3" "145.3" "125.6" "133.0" "" "" "" "" "" "" "" "" "" "" "136.4" "118.0" "86.0" "97.2" "123.4" "109.5" "123.5" "124.9" "98.0" "119.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "16.363" "8" "2" "3" "2" "296" "33.5" "8.44" "11.35" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "Macrophage markers" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "3" "0" "0.949" "0.869" "0.912" "1.014" "0.917" "0.967" "1.078" "0.846" "1.017" "78.8" "74.8" "68.4" "71.9" "79.9" "72.2" "76.2" "84.9" "66.6" "80.1" "" "" "" "" "" "" "" "" "" "" "78.8" "63.3" "43.3" "52.4" "65.5" "56.1" "58.7" "73.0" "52.0" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "16.358" "6" "4" "8" "1" "585" "63.8" "9.04" "26.13" "4" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "16.336" "14" "4" "6" "4" "334" "37.6" "6.54" "20.16" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "TGF-beta signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "1.115" "1.033" "1.189" "1.005" "1.038" "1.091" "0.978" "0.941" "0.971" "275.0" "306.5" "283.9" "327.0" "276.2" "285.4" "300.0" "269.0" "258.8" "267.0" "" "" "" "" "" "" "" "" "" "" "275.0" "259.3" "179.5" "238.4" "226.3" "221.7" "231.3" "231.3" "202.0" "240.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "16.334" "10" "5" "6" "5" "689" "78.5" "6.42" "14.22" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.085" "0.997" "1.039" "1.115" "1.024" "1.076" "1.012" "0.926" "1.037" "322.0" "349.4" "321.1" "334.5" "359.1" "329.6" "346.5" "325.8" "298.3" "333.9" "" "" "" "" "" "" "" "" "" "" "322.0" "295.6" "203.0" "243.9" "294.2" "255.9" "267.1" "280.1" "232.8" "300.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "16.319" "15" "2" "5" "2" "140" "15.8" "9.10" "20.21" "2" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.964" "1.021" "0.975" "1.002" "1.088" "1.077" "0.955" "1.039" "1.030" "602.7" "581.2" "615.0" "587.8" "603.9" "655.5" "649.1" "575.8" "626.4" "620.8" "" "" "" "" "" "" "" "" "" "" "602.7" "491.7" "388.9" "428.6" "494.8" "509.1" "500.3" "495.1" "488.9" "558.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "16.307" "24" "4" "5" "4" "181" "20.5" "8.82" "16.93" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "0.964" "1.046" "0.881" "0.948" "1.038" "0.980" "0.970" "1.006" "1.066" "205.1" "197.6" "214.5" "180.7" "194.3" "212.9" "200.9" "198.9" "206.3" "218.7" "" "" "" "" "" "" "" "" "" "" "205.1" "167.2" "135.6" "131.8" "159.2" "165.3" "154.8" "171.0" "161.0" "196.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "16.300" "22" "3" "3" "3" "147" "16.8" "4.74" "11.18" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "16" "0" "1.031" "0.962" "1.039" "1.097" "0.918" "1.060" "0.966" "0.923" "0.950" "252.5" "260.3" "242.9" "262.4" "276.9" "231.7" "267.7" "244.0" "233.1" "239.9" "" "" "" "" "" "" "" "" "" "" "252.5" "220.2" "153.6" "191.3" "226.9" "179.9" "206.4" "209.8" "182.0" "215.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.000" "False" "16.294" "4" "5" "5" "5" "1291" "143.1" "6.02" "14.55" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "Histone modifications; Pleural mesothelioma" "PKMTs methylate histone lysines" "3" "0" "1.105" "0.932" "0.986" "0.871" "0.669" "0.879" "0.898" "0.857" "0.926" "106.3" "117.4" "99.0" "104.8" "92.6" "71.1" "93.4" "95.4" "91.0" "98.4" "" "" "" "" "" "" "" "" "" "" "106.3" "99.3" "62.6" "76.4" "75.9" "55.2" "72.0" "82.1" "71.0" "88.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "16.266" "11" "6" "8" "6" "562" "58.2" "8.63" "22.06" "6" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.029" "1.069" "0.906" "1.036" "1.087" "1.075" "1.001" "1.078" "0.939" "458.9" "472.0" "490.7" "415.9" "475.3" "499.0" "493.2" "459.3" "494.8" "430.9" "" "" "" "" "" "" "" "" "" "" "458.9" "399.3" "310.2" "303.2" "389.5" "387.5" "380.1" "394.9" "386.2" "387.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-274346279625731140" "False" "High" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "0.000" "False" "16.254" "6" "5" "5" "5" "708" "81.8" "6.71" "15.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393, Pf20667" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "0.943" "0.925" "1.031" "0.948" "0.872" "0.950" "0.952" "0.866" "1.056" "276.2" "260.5" "255.5" "284.8" "261.8" "240.8" "262.4" "262.8" "239.3" "291.6" "" "" "" "" "" "" "" "" "" "" "276.2" "220.4" "161.6" "207.6" "214.5" "187.0" "202.3" "225.9" "186.8" "262.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.000" "False" "16.238" "36" "4" "5" "4" "137" "14.3" "8.19" "19.09" "4" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "4" "0" "0.961" "0.926" "1.131" "0.973" "1.054" "1.040" "0.955" "1.057" "1.094" "98.9" "95.1" "91.6" "111.9" "96.3" "104.3" "102.9" "94.5" "104.6" "108.2" "" "" "" "" "" "" "" "" "" "" "98.9" "80.4" "57.9" "81.6" "78.9" "81.0" "79.3" "81.3" "81.7" "97.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "16.232" "5" "3" "3" "3" "729" "77.8" "6.79" "11.48" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "5" "0" "1.042" "0.784" "0.995" "1.047" "0.923" "1.004" "0.953" "0.756" "0.838" "117.2" "122.1" "91.9" "116.6" "122.7" "108.1" "117.7" "111.7" "88.6" "98.2" "" "" "" "" "" "" "" "" "" "" "117.2" "103.3" "58.1" "85.0" "100.5" "84.0" "90.7" "96.0" "69.2" "88.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "16.209" "13" "5" "7" "5" "339" "37.8" "4.97" "21.58" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.055" "0.984" "0.979" "0.910" "0.840" "0.918" "0.878" "0.909" "0.947" "256.2" "270.4" "252.2" "250.9" "233.2" "215.2" "235.1" "225.0" "232.8" "242.7" "" "" "" "" "" "" "" "" "" "" "256.2" "228.8" "159.4" "182.9" "191.1" "167.1" "181.2" "193.5" "181.8" "218.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "16.200" "10" "4" "4" "4" "434" "46.7" "4.42" "13.62" "4" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Nucleotide-binding oligomerization domain (NOD) pathway" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "5" "0" "0.947" "0.765" "1.017" "0.945" "0.809" "1.011" "0.940" "0.823" "0.887" "329.9" "312.3" "252.5" "335.4" "311.7" "266.7" "333.6" "310.3" "271.4" "292.7" "" "" "" "" "" "" "" "" "" "" "329.9" "264.2" "159.6" "244.5" "255.3" "207.2" "257.2" "266.8" "211.9" "263.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9197774965471602114" "False" "High" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "0.000" "False" "16.194" "8" "4" "4" "4" "597" "68.5" "8.13" "13.02" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "mRNA processing; Ciliary landscape" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "1.285" "1.001" "1.217" "1.150" "0.908" "0.995" "1.211" "0.786" "1.062" "35.5" "45.6" "35.5" "43.2" "40.8" "32.2" "35.3" "43.0" "27.9" "37.7" "" "" "" "" "" "" "" "" "" "" "35.5" "38.6" "22.5" "31.5" "33.5" "25.0" "27.2" "37.0" "21.8" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "16.184" "6" "4" "7" "1" "601" "66.2" "4.94" "19.93" "4" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "40" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "16.182" "21" "2" "5" "2" "125" "14.6" "9.38" "13.09" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.001" "0.992" "0.836" "1.014" "1.090" "0.930" "1.028" "0.899" "1.048" "117.9" "118.0" "116.9" "98.5" "119.6" "128.5" "109.6" "121.2" "106.0" "123.5" "" "" "" "" "" "" "" "" "" "" "117.9" "99.8" "73.9" "71.9" "98.0" "99.8" "84.5" "104.2" "82.7" "111.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "16.181" "11" "5" "5" "5" "463" "50.3" "8.15" "17.24" "5" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Cerebral organic acidurias, including diseases" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "0.989" "0.902" "0.983" "1.105" "0.923" "1.013" "1.014" "0.905" "1.070" "413.8" "409.2" "373.2" "406.8" "457.2" "382.0" "419.0" "419.4" "374.6" "442.8" "" "" "" "" "" "" "" "" "" "" "413.8" "346.2" "236.0" "296.6" "374.6" "296.6" "323.0" "360.6" "292.4" "398.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "16.176" "8" "3" "5" "3" "351" "38.7" "6.09" "15.68" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.120" "0.954" "1.059" "1.034" "0.902" "1.096" "1.058" "0.930" "1.011" "195.3" "218.7" "186.2" "206.9" "202.0" "176.2" "214.1" "206.5" "181.7" "197.5" "" "" "" "" "" "" "" "" "" "" "195.3" "185.0" "117.7" "150.8" "165.5" "136.8" "165.0" "177.6" "141.8" "177.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "High" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.000" "False" "16.162" "11" "3" "4" "3" "243" "27.7" "8.07" "13.91" "3" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Gastric cancer network 2" "Cell surface interactions at the vascular wall" "2" "0" "0.873" "0.707" "0.878" "0.806" "0.641" "0.900" "0.902" "0.593" "0.810" "629.9" "549.8" "445.1" "553.0" "507.7" "403.6" "567.0" "568.4" "373.4" "510.4" "" "" "" "" "" "" "" "" "" "" "629.9" "465.1" "281.4" "403.2" "416.0" "313.4" "437.1" "488.7" "291.5" "458.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "High" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.000" "False" "16.154" "3" "5" "5" "5" "1518" "165.8" "5.91" "15.44" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "Primary ovarian insufficiency" "" "1" "0" "0.963" "0.956" "1.027" "1.039" "0.970" "1.135" "1.205" "1.073" "1.022" "105.6" "101.7" "100.9" "108.4" "109.7" "102.5" "119.9" "127.2" "113.3" "107.9" "" "" "" "" "" "" "" "" "" "" "105.6" "86.1" "63.8" "79.1" "89.9" "79.6" "92.4" "109.4" "88.4" "97.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "16.135" "9" "3" "4" "3" "419" "48.2" "5.71" "14.39" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Downstream TCR signaling; NOD1/2 Signaling Pathway; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; activated TAK1 mediates p38 MAPK activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "76" "0" "0.998" "0.882" "1.049" "1.134" "0.933" "1.075" "0.981" "0.851" "1.070" "170.2" "169.8" "150.1" "178.4" "193.0" "158.7" "182.9" "166.9" "144.9" "182.1" "" "" "" "" "" "" "" "" "" "" "170.2" "143.7" "94.9" "130.1" "158.1" "123.3" "141.0" "143.5" "113.1" "163.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "16.133" "18" "4" "7" "4" "227" "24.6" "7.21" "23.48" "4" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Primary ovarian insufficiency" "Protein repair" "2" "0" "1.010" "1.026" "0.978" "1.040" "1.063" "1.079" "1.071" "1.208" "1.050" "388.2" "392.2" "398.4" "379.6" "403.9" "412.8" "419.0" "415.8" "469.0" "407.5" "" "" "" "" "" "" "" "" "" "" "388.2" "331.9" "251.9" "276.8" "330.9" "320.6" "322.9" "357.5" "366.1" "366.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "16.127" "12" "4" "5" "4" "484" "53.5" "10.52" "8.95" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "0.982" "1.021" "0.997" "0.957" "1.036" "0.931" "1.048" "0.883" "1.010" "99.9" "98.1" "102.0" "99.6" "95.6" "103.5" "93.1" "104.7" "88.3" "100.9" "" "" "" "" "" "" "" "" "" "" "99.9" "83.0" "64.5" "72.7" "78.4" "80.4" "71.7" "90.0" "68.9" "90.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "16.058" "16" "1" "3" "1" "147" "15.9" "4.86" "18.12" "1" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "0.916" "1.066" "0.927" "1.002" "1.117" "1.136" "0.969" "0.989" "1.220" "96.7" "88.5" "103.0" "89.6" "96.9" "107.9" "109.8" "93.6" "95.6" "117.9" "" "" "" "" "" "" "" "" "" "" "96.7" "74.9" "65.2" "65.3" "79.4" "83.8" "84.6" "80.5" "74.6" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "16.030" "22" "2" "5" "2" "102" "11.5" "4.16" "14.90" "2" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "IL-18 signaling pathway" "" "1" "0" "0.847" "1.025" "1.007" "0.941" "1.088" "1.104" "0.931" "1.089" "1.043" "262.5" "222.3" "269.0" "264.4" "246.9" "285.7" "289.7" "244.3" "285.7" "273.7" "" "" "" "" "" "" "" "" "" "" "262.5" "188.0" "170.1" "192.8" "202.3" "221.8" "223.3" "210.0" "223.0" "246.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "16.030" "7" "5" "7" "5" "782" "87.9" "6.13" "24.68" "5" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.087" "0.889" "1.105" "1.073" "0.985" "1.115" "1.135" "0.933" "1.074" "399.0" "433.7" "354.7" "440.8" "428.1" "393.2" "445.1" "453.1" "372.3" "428.5" "" "" "" "" "" "" "" "" "" "" "399.0" "366.9" "224.3" "321.4" "350.7" "305.4" "343.1" "389.5" "290.6" "385.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "16.027" "6" "4" "7" "4" "793" "91.0" "7.18" "15.60" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "1.048" "0.784" "0.926" "1.046" "0.960" "1.053" "0.962" "0.904" "0.812" "243.2" "254.9" "190.7" "225.3" "254.4" "233.5" "256.0" "234.0" "219.9" "197.6" "" "" "" "" "" "" "" "" "" "" "243.2" "215.7" "120.6" "164.3" "208.4" "181.3" "197.3" "201.2" "171.7" "177.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "High" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.000" "False" "16.016" "5" "6" "6" "6" "1133" "127.7" "8.50" "17.47" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.897" "0.802" "0.976" "0.963" "0.948" "0.999" "0.973" "0.968" "1.010" "236.7" "212.3" "189.9" "231.0" "227.8" "224.4" "236.5" "230.3" "229.1" "239.0" "" "" "" "" "" "" "" "" "" "" "236.7" "179.6" "120.1" "168.5" "186.7" "174.3" "182.3" "198.0" "178.9" "214.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "16.005" "8" "2" "5" "2" "360" "40.2" "10.33" "22.19" "2" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "1.140" "1.170" "1.099" "1.133" "1.319" "1.257" "1.017" "1.210" "1.211" "114.1" "130.1" "133.5" "125.3" "129.3" "150.5" "143.4" "116.1" "138.0" "138.2" "" "" "" "" "" "" "" "" "" "" "114.1" "110.0" "84.4" "91.4" "105.9" "116.9" "110.5" "99.8" "107.7" "124.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "15.995" "17" "4" "11" "3" "266" "29.9" "7.74" "34.95" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "17" "0" "1.071" "1.241" "1.082" "1.073" "1.186" "1.138" "1.090" "1.226" "1.161" "464.7" "497.7" "576.7" "502.8" "498.7" "551.2" "528.8" "506.6" "569.7" "539.6" "" "" "" "" "" "" "" "" "" "" "464.7" "421.1" "364.6" "366.6" "408.6" "428.0" "407.6" "435.5" "444.7" "485.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "15.989" "6" "5" "6" "4" "835" "95.3" "7.05" "18.44" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.076" "0.878" "1.050" "1.168" "0.962" "1.043" "1.018" "0.955" "1.008" "310.6" "334.4" "272.6" "326.3" "362.9" "298.9" "323.9" "316.2" "296.5" "313.0" "" "" "" "" "" "" "" "" "" "" "310.6" "282.9" "172.4" "237.9" "297.3" "232.2" "249.7" "271.8" "231.5" "281.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "15.988" "7" "3" "3" "3" "689" "74.3" "9.57" "11.85" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.000" "False" "15.975" "5" "5" "6" "5" "863" "97.3" "5.53" "18.77" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "2" "0" "0.921" "0.900" "1.058" "0.989" "0.918" "1.000" "1.061" "0.861" "1.005" "303.4" "279.3" "273.0" "320.9" "300.2" "278.5" "303.5" "322.0" "261.2" "305.1" "" "" "" "" "" "" "" "" "" "" "303.4" "236.3" "172.6" "234.0" "245.9" "216.3" "233.9" "276.8" "203.9" "274.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "15.972" "9" "5" "7" "5" "616" "65.3" "9.29" "19.00" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "Prion disease pathway; IL-18 signaling pathway" "" "2" "0" "1.260" "1.134" "1.150" "1.221" "1.079" "1.330" "1.086" "1.138" "1.141" "132.0" "166.3" "149.6" "151.8" "161.2" "142.5" "175.5" "143.3" "150.2" "150.6" "" "" "" "" "" "" "" "" "" "" "132.0" "140.7" "94.6" "110.7" "132.0" "110.6" "135.3" "123.2" "117.2" "135.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "15.968" "8" "4" "4" "4" "822" "91.9" "6.65" "13.58" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "1.220" "0.918" "1.329" "1.204" "1.116" "1.299" "1.296" "1.034" "1.147" "146.2" "178.4" "134.3" "194.4" "176.1" "163.1" "189.9" "189.5" "151.2" "167.8" "" "" "" "" "" "" "" "" "" "" "146.2" "150.9" "84.9" "141.7" "144.3" "126.7" "146.4" "163.0" "118.0" "150.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "15.968" "45" "4" "4" "4" "83" "9.3" "5.12" "15.10" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "" "Mitochondrial protein import" "1" "0" "1.060" "0.914" "1.040" "0.950" "1.042" "1.213" "0.993" "1.008" "0.944" "397.4" "421.4" "363.1" "413.3" "377.7" "413.9" "482.0" "394.7" "400.5" "375.1" "" "" "" "" "" "" "" "" "" "" "397.4" "356.5" "229.6" "301.4" "309.5" "321.5" "371.6" "339.4" "312.6" "337.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "15.939" "10" "4" "5" "4" "423" "47.8" "6.65" "18.16" "4" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; Neddylation; DNA Damage Recognition in GG-NER" "6" "0" "1.169" "0.956" "1.210" "0.987" "1.117" "1.192" "0.984" "1.050" "0.977" "63.7" "74.5" "60.9" "77.1" "62.9" "71.2" "76.0" "62.7" "66.9" "62.3" "" "" "" "" "" "" "" "" "" "" "63.7" "63.0" "38.5" "56.2" "51.5" "55.3" "58.6" "53.9" "52.2" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2873393245892861627" "False" "High" "IsMasterProtein" "Q9UI15" "Transgelin-3 OS=Homo sapiens OX=9606 GN=TAGLN3 PE=1 SV=2" "0.000" "False" "15.937" "14" "2" "8" "1" "199" "22.5" "7.33" "21.34" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf00307, Pf00402" "29114" "ENSG00000144834" "TAGLN3" "D3DN64; hsa:29114; Q96A74; Q9UI15" "" "" "0" "0" "0.966" "0.996" "0.981" "1.032" "1.033" "1.340" "1.000" "1.112" "1.138" "63.1" "60.9" "62.8" "61.9" "65.1" "65.2" "84.5" "63.0" "70.1" "71.8" "" "" "" "" "" "" "" "" "" "" "63.1" "51.5" "39.7" "45.1" "53.3" "50.6" "65.1" "54.2" "54.7" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "15.909" "15" "6" "9" "2" "379" "43.1" "6.74" "26.89" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; Interferon gamma signaling; ISG15 antiviral mechanism; Signal transduction by L1; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Oxidative Stress Induced Senescence; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "178" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "15.896" "2" "3" "5" "3" "1463" "164.6" "8.41" "14.15" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "Apoptosis" "" "1" "0" "1.060" "1.139" "1.214" "1.073" "1.306" "1.065" "1.056" "1.103" "1.196" "134.4" "142.4" "153.1" "163.1" "144.2" "175.5" "143.1" "141.9" "148.2" "160.8" "" "" "" "" "" "" "" "" "" "" "134.4" "120.5" "96.8" "118.9" "118.1" "136.3" "110.3" "122.0" "115.7" "144.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "15.868" "22" "4" "6" "4" "157" "17.8" "8.66" "18.57" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.960" "1.008" "1.068" "1.047" "1.021" "1.003" "1.025" "1.090" "1.094" "410.4" "393.9" "413.9" "438.5" "429.9" "419.0" "411.6" "420.8" "447.2" "448.9" "" "" "" "" "" "" "" "" "" "" "410.4" "333.2" "261.7" "319.8" "352.2" "325.4" "317.3" "361.8" "349.1" "403.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6260636582982827540" "False" "High" "IsMasterProtein" "Q6YHU6" "tRNA (32-2'-O)-methyltransferase regulator THADA OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1" "0.000" "False" "15.868" "2" "4" "4" "4" "1953" "219.5" "6.06" "14.92" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity" "Pf10350" "63892" "ENSG00000115970" "THADA" "A8K1V8; B7WNS6; hsa:63892; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6YHU6; Q6ZU38; Q8IY32; Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.083" "1.018" "1.085" "1.073" "0.998" "1.038" "1.009" "1.048" "1.004" "184.6" "199.9" "188.0" "200.3" "198.1" "184.2" "191.7" "186.2" "193.6" "185.5" "" "" "" "" "" "" "" "" "" "" "184.6" "169.2" "118.9" "146.0" "162.3" "143.0" "147.8" "160.1" "151.1" "166.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "15.862" "9" "4" "5" "4" "594" "66.5" "5.59" "12.61" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "6" "0" "0.988" "1.353" "1.383" "1.175" "1.429" "1.098" "1.068" "1.523" "1.264" "39.2" "38.7" "53.0" "54.2" "46.0" "56.0" "43.0" "41.8" "59.6" "49.5" "" "" "" "" "" "" "" "" "" "" "39.2" "32.7" "33.5" "39.5" "37.7" "43.5" "33.1" "36.0" "46.5" "44.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "High" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.000" "False" "15.859" "1" "5" "5" "5" "3259" "375.8" "5.00" "13.54" "5" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "3" "0" "0.892" "1.241" "1.034" "1.168" "1.077" "1.177" "1.129" "1.209" "0.938" "64.7" "57.7" "80.3" "66.9" "75.6" "69.7" "76.2" "73.0" "78.2" "60.7" "" "" "" "" "" "" "" "" "" "" "64.7" "48.8" "50.8" "48.8" "61.9" "54.1" "58.7" "62.8" "61.1" "54.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "15.850" "8" "5" "5" "5" "651" "70.8" "8.51" "16.27" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "10" "0" "1.056" "1.042" "1.102" "1.129" "1.019" "1.121" "1.100" "1.065" "1.047" "283.8" "299.9" "295.6" "312.8" "320.6" "289.1" "318.3" "312.2" "302.2" "297.1" "" "" "" "" "" "" "" "" "" "" "283.8" "253.7" "186.9" "228.1" "262.7" "224.5" "245.4" "268.4" "235.9" "267.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "15.848" "20" "4" "5" "4" "223" "25.8" "9.54" "17.96" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.982" "1.190" "0.989" "1.141" "1.498" "1.228" "1.213" "1.521" "1.190" "204.2" "200.4" "242.9" "202.0" "232.9" "305.8" "250.7" "247.7" "310.5" "243.0" "" "" "" "" "" "" "" "" "" "" "204.2" "169.6" "153.6" "147.3" "190.8" "237.5" "193.2" "213.0" "242.4" "218.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "15.828" "7" "3" "8" "3" "467" "54.7" "6.95" "24.89" "3" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Negative regulation of MAPK pathway; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "28" "0" "1.045" "0.959" "0.978" "1.007" "1.042" "1.021" "1.111" "1.058" "0.966" "273.9" "286.2" "262.7" "268.0" "275.8" "285.4" "279.8" "304.2" "289.9" "264.5" "" "" "" "" "" "" "" "" "" "" "273.9" "242.1" "166.1" "195.4" "225.9" "221.6" "215.7" "261.6" "226.3" "237.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "15.807" "16" "3" "5" "3" "190" "21.5" "4.94" "18.04" "3" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "0.963" "1.029" "1.073" "1.012" "1.043" "1.142" "1.055" "1.025" "1.008" "624.1" "601.1" "642.4" "669.4" "631.9" "650.9" "712.5" "658.4" "639.9" "629.0" "" "" "" "" "" "" "" "" "" "" "624.1" "508.5" "406.2" "488.1" "517.7" "505.5" "549.2" "566.1" "499.5" "565.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "15.795" "22" "4" "9" "4" "200" "22.4" "5.44" "23.53" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "1.107" "1.076" "1.423" "1.130" "1.139" "1.241" "1.139" "1.144" "1.297" "105.0" "116.3" "113.0" "149.5" "118.6" "119.6" "130.3" "119.7" "120.1" "136.2" "" "" "" "" "" "" "" "" "" "" "105.0" "98.4" "71.5" "109.0" "97.2" "92.9" "100.4" "102.9" "93.8" "122.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "15.783" "8" "4" "5" "4" "512" "57.9" "4.42" "13.27" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "1.019" "0.963" "0.994" "1.012" "0.956" "1.016" "1.050" "1.055" "1.104" "180.8" "184.3" "174.1" "179.7" "183.0" "172.8" "183.7" "189.8" "190.8" "199.7" "" "" "" "" "" "" "" "" "" "" "180.8" "155.9" "110.1" "131.0" "149.9" "134.2" "141.6" "163.2" "149.0" "179.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "15.774" "10" "3" "4" "3" "346" "39.0" "8.47" "10.55" "3" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "43" "0" "0.993" "0.868" "0.952" "1.149" "0.882" "1.140" "1.107" "0.946" "1.148" "54.7" "54.3" "47.5" "52.1" "62.8" "48.2" "62.4" "60.5" "51.7" "62.8" "" "" "" "" "" "" "" "" "" "" "54.7" "46.0" "30.0" "38.0" "51.5" "37.5" "48.1" "52.1" "40.4" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "15.754" "19" "4" "9" "4" "178" "20.5" "8.59" "25.44" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.023" "1.096" "1.065" "1.007" "0.991" "1.003" "1.065" "0.983" "1.029" "412.1" "421.4" "451.6" "438.7" "414.8" "408.6" "413.4" "439.1" "405.1" "424.1" "" "" "" "" "" "" "" "" "" "" "412.1" "356.5" "285.5" "319.9" "339.9" "317.3" "318.7" "377.5" "316.2" "381.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "15.748" "21" "3" "6" "3" "228" "25.7" "7.25" "18.91" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.969" "1.017" "0.993" "1.014" "1.054" "1.023" "1.027" "0.965" "1.046" "246.6" "238.9" "250.8" "245.0" "250.1" "259.8" "252.3" "253.2" "237.9" "257.9" "" "" "" "" "" "" "" "" "" "" "246.6" "202.1" "158.6" "178.6" "204.9" "201.8" "194.5" "217.7" "185.7" "231.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "15.740" "3" "3" "4" "3" "1170" "129.9" "6.93" "15.15" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "1.047" "0.836" "1.074" "0.990" "0.913" "1.052" "0.950" "0.713" "0.868" "113.9" "119.3" "95.1" "122.3" "112.8" "104.0" "119.8" "108.1" "81.2" "98.8" "" "" "" "" "" "" "" "" "" "" "113.9" "100.9" "60.2" "89.2" "92.4" "80.8" "92.3" "93.0" "63.4" "88.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "15.732" "34" "4" "4" "4" "131" "13.8" "9.77" "12.47" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "0.960" "1.012" "0.956" "0.973" "1.055" "1.012" "0.877" "1.006" "0.994" "432.8" "415.4" "438.1" "413.7" "421.2" "456.6" "438.0" "379.8" "435.3" "430.3" "" "" "" "" "" "" "" "" "" "" "432.8" "351.4" "277.0" "301.6" "345.1" "354.6" "337.7" "326.5" "339.8" "386.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "15.687" "6" "3" "4" "3" "622" "69.8" "6.84" "10.94" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "5q35 copy number variation" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "15.681" "8" "2" "3" "2" "396" "44.6" "5.03" "10.44" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "0.971" "0.968" "0.950" "0.976" "0.986" "1.090" "1.024" "0.890" "0.926" "160.1" "155.3" "155.0" "152.1" "156.3" "157.8" "174.5" "163.9" "142.5" "148.3" "" "" "" "" "" "" "" "" "" "" "160.1" "131.4" "98.0" "110.9" "128.0" "122.6" "134.5" "140.9" "111.2" "133.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "15.677" "24" "5" "10" "5" "177" "19.2" "8.07" "25.27" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "1.051" "1.062" "0.991" "1.110" "1.106" "1.020" "1.068" "1.093" "1.066" "424.7" "446.3" "451.0" "420.7" "471.4" "469.7" "433.3" "453.7" "464.2" "452.8" "" "" "" "" "" "" "" "" "" "" "424.7" "377.5" "285.2" "306.8" "386.2" "364.8" "334.0" "390.1" "362.3" "407.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "15.676" "4" "4" "4" "4" "906" "100.0" "6.29" "12.83" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "15" "0" "0.996" "0.877" "1.126" "0.892" "0.856" "0.926" "1.184" "0.666" "0.900" "101.0" "100.6" "88.6" "113.7" "90.1" "86.4" "93.5" "119.6" "67.3" "90.8" "" "" "" "" "" "" "" "" "" "" "101.0" "85.1" "56.0" "82.9" "73.8" "67.1" "72.1" "102.8" "52.5" "81.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7881341601402710105" "False" "High" "IsMasterProtein" "Q8IYQ7" "Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2" "0.000" "False" "15.623" "7" "5" "5" "5" "743" "83.0" "7.12" "14.60" "5" "" "other cell component" "" "Pf01202, Pf14821" "79896" "ENSG00000185875" "THNSL1" "B3KWL1; D3DRV3; hsa:79896; Q5VV21; Q8IYQ7" "" "" "0" "0" "1.074" "0.927" "1.110" "1.120" "0.959" "1.094" "1.076" "1.132" "1.104" "297.7" "319.7" "276.0" "330.4" "333.3" "285.6" "325.6" "320.2" "337.1" "328.6" "" "" "" "" "" "" "" "" "" "" "297.7" "270.5" "174.5" "240.9" "273.1" "221.8" "251.0" "275.3" "263.2" "295.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "15.622" "19" "3" "4" "3" "206" "22.1" "7.65" "14.33" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "5" "0" "1.005" "0.990" "1.265" "1.169" "0.887" "1.155" "1.215" "0.936" "0.988" "153.3" "154.1" "151.8" "194.0" "179.3" "136.0" "177.2" "186.3" "143.5" "151.5" "" "" "" "" "" "" "" "" "" "" "153.3" "130.4" "96.0" "141.5" "146.9" "105.6" "136.6" "160.2" "112.0" "136.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "15.622" "20" "4" "7" "4" "185" "20.1" "5.22" "21.75" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "1.041" "0.862" "1.061" "0.989" "0.794" "1.043" "1.011" "0.791" "0.941" "586.9" "611.1" "506.2" "622.7" "580.5" "466.0" "612.0" "593.5" "464.3" "552.4" "" "" "" "" "" "" "" "" "" "" "586.9" "517.0" "320.1" "454.1" "475.6" "361.9" "471.7" "510.3" "362.4" "496.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "15.620" "4" "3" "4" "3" "846" "95.0" "7.72" "13.86" "3" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "" "3" "0" "1.119" "0.882" "0.873" "0.989" "0.982" "1.068" "1.038" "0.843" "1.138" "130.5" "146.0" "115.1" "114.0" "129.1" "128.1" "139.4" "135.4" "109.9" "148.5" "" "" "" "" "" "" "" "" "" "" "130.5" "123.5" "72.8" "83.1" "105.7" "99.5" "107.5" "116.4" "85.8" "133.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "689463057038776482" "False" "High" "IsMasterProtein" "Q6ZS17" "Rho family-interacting cell polarization regulator 1 OS=Homo sapiens OX=9606 GN=RIPOR1 PE=1 SV=1" "0.000" "False" "15.613" "4" "4" "5" "4" "1223" "132.2" "6.28" "12.62" "4" "stress response;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf15903" "79567" "ENSG00000039523" "RIPOR1" "B4DEQ9; B4DIM2; E9PBS3; hsa:79567; Q4G0A4; Q6ZS17; Q7Z5R7; Q8NDA4; Q96J39; Q96PV8; Q9H8D9" "" "" "0" "0" "1.013" "0.875" "0.937" "1.083" "1.000" "0.983" "1.100" "0.993" "1.053" "213.4" "216.1" "186.7" "199.9" "231.2" "213.5" "209.8" "234.7" "211.9" "224.7" "" "" "" "" "" "" "" "" "" "" "213.4" "182.8" "118.1" "145.7" "189.4" "165.8" "161.8" "201.8" "165.4" "202.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "High" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.000" "False" "15.594" "31" "3" "3" "3" "163" "17.7" "5.19" "11.38" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "3" "0" "0.996" "0.909" "1.089" "0.992" "0.843" "1.134" "0.964" "0.930" "0.943" "153.9" "153.3" "139.9" "167.6" "152.6" "129.7" "174.6" "148.4" "143.1" "145.0" "" "" "" "" "" "" "" "" "" "" "153.9" "129.7" "88.5" "122.2" "125.0" "100.7" "134.6" "127.6" "111.7" "130.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "15.593" "6" "3" "5" "3" "568" "65.5" "6.19" "13.69" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.018" "0.846" "0.969" "1.097" "0.932" "0.999" "1.087" "0.869" "0.913" "319.2" "325.1" "270.1" "309.4" "350.3" "297.6" "319.0" "346.9" "277.4" "291.3" "" "" "" "" "" "" "" "" "" "" "319.2" "275.0" "170.8" "225.6" "287.0" "231.1" "245.9" "298.3" "216.5" "261.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "15.591" "33" "3" "7" "3" "86" "10.1" "7.97" "19.97" "3" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.968" "1.005" "0.952" "1.039" "0.894" "0.900" "0.931" "0.930" "0.953" "112.4" "108.8" "113.0" "107.0" "116.8" "100.5" "101.1" "104.6" "104.6" "107.1" "" "" "" "" "" "" "" "" "" "" "112.4" "92.1" "71.4" "78.0" "95.7" "78.0" "77.9" "90.0" "81.6" "96.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5265324397927722466" "False" "High" "IsMasterProtein" "Q6PIW4" "Fidgetin-like protein 1 OS=Homo sapiens OX=9606 GN=FIGNL1 PE=1 SV=2" "0.000" "False" "15.589" "8" "4" "4" "4" "674" "74.0" "7.85" "14.04" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004, Pf09336, Pf17862" "63979" "ENSG00000132436" "FIGNL1" "D3DVM6; hsa:63979; Q6PIW4; Q86V18; Q8ND59; Q9H8P1; Q9H917" "" "" "0" "0" "1.186" "0.882" "1.202" "1.230" "0.892" "1.277" "1.175" "1.010" "1.008" "82.5" "97.9" "72.8" "99.2" "101.5" "73.6" "105.3" "97.0" "83.3" "83.2" "" "" "" "" "" "" "" "" "" "" "82.5" "82.8" "46.0" "72.3" "83.2" "57.1" "81.2" "83.4" "65.0" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288326920404565316" "False" "High" "IsMasterProtein" "O15111" "Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2" "0.000" "False" "15.579" "8" "5" "5" "4" "745" "84.6" "6.73" "16.65" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "1147" "ENSG00000213341" "CHUK" "hsa:1147; O14666; O15111; Q13132; Q5W0I4; Q92467" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; AKT phosphorylates targets in the cytosol" "86" "0" "1.033" "1.069" "0.960" "1.180" "0.784" "0.991" "1.009" "0.828" "1.005" "23.8" "24.5" "25.4" "22.8" "28.0" "18.6" "23.6" "24.0" "19.7" "23.9" "" "" "" "" "" "" "" "" "" "" "23.8" "20.8" "16.1" "16.6" "23.0" "14.5" "18.2" "20.6" "15.3" "21.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "15.558" "5" "2" "5" "2" "478" "50.7" "9.10" "15.60" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "0.937" "1.069" "1.094" "0.902" "1.068" "0.997" "0.873" "1.031" "0.962" "160.1" "150.0" "171.2" "175.1" "144.5" "171.0" "159.6" "139.7" "165.1" "154.0" "" "" "" "" "" "" "" "" "" "" "160.1" "126.9" "108.3" "127.7" "118.4" "132.8" "123.0" "120.2" "128.9" "138.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "15.552" "12" "4" "4" "4" "348" "38.6" "9.48" "13.57" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.105" "1.023" "1.035" "1.074" "1.089" "1.046" "1.114" "0.947" "0.941" "313.0" "345.9" "320.2" "324.1" "336.2" "340.8" "327.3" "348.6" "296.4" "294.5" "" "" "" "" "" "" "" "" "" "" "313.0" "292.6" "202.5" "236.3" "275.4" "264.7" "252.3" "299.8" "231.4" "264.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3915104900764818222" "False" "High" "IsMasterProtein" "Q86TG7" "Retrotransposon-derived protein PEG10 OS=Homo sapiens OX=9606 GN=PEG10 PE=1 SV=2" "0.000" "False" "15.546" "4" "2" "4" "2" "708" "80.1" "6.39" "14.71" "2" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16297" "23089" "ENSG00000242265" "PEG10" "B4DSP0; hsa:23089; Q86TG7; Q96A68; Q9UPV1" "" "" "0" "0" "1.021" "0.774" "1.088" "1.014" "0.739" "1.131" "1.030" "0.697" "0.885" "140.6" "143.6" "108.8" "153.1" "142.6" "103.9" "159.0" "144.8" "98.1" "124.5" "" "" "" "" "" "" "" "" "" "" "140.6" "121.5" "68.8" "111.6" "116.9" "80.7" "122.6" "124.5" "76.6" "111.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "15.534" "14" "5" "5" "5" "340" "38.5" "7.20" "14.64" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.004" "0.722" "1.113" "0.944" "0.804" "0.978" "0.978" "0.889" "0.948" "69.3" "69.6" "50.1" "77.1" "65.4" "55.7" "67.8" "67.8" "61.6" "65.7" "" "" "" "" "" "" "" "" "" "" "69.3" "58.9" "31.6" "56.2" "53.6" "43.3" "52.2" "58.3" "48.1" "59.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "15.529" "20" "5" "6" "5" "246" "28.1" "6.77" "17.76" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "5" "0" "0.982" "1.067" "0.933" "0.962" "1.086" "0.944" "1.035" "1.015" "0.973" "424.1" "416.3" "452.6" "395.8" "408.2" "460.7" "400.3" "438.8" "430.4" "412.5" "" "" "" "" "" "" "" "" "" "" "424.1" "352.2" "286.2" "288.6" "334.4" "357.8" "308.6" "377.3" "336.0" "370.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "15.524" "10" "3" "3" "3" "356" "38.1" "9.83" "11.95" "3" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "0.872" "0.972" "1.160" "1.014" "0.926" "0.923" "1.004" "0.989" "0.885" "266.7" "232.7" "259.3" "309.3" "270.4" "247.1" "246.1" "267.7" "263.8" "236.2" "" "" "" "" "" "" "" "" "" "" "266.7" "196.8" "163.9" "225.5" "221.5" "191.9" "189.7" "230.2" "205.9" "212.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "15.506" "6" "2" "4" "2" "309" "35.8" "6.80" "13.57" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "1.065" "0.990" "1.012" "1.066" "0.996" "1.005" "1.060" "0.948" "0.991" "296.7" "316.1" "293.9" "300.2" "316.3" "295.6" "298.1" "314.4" "281.4" "294.0" "" "" "" "" "" "" "" "" "" "" "296.7" "267.5" "185.8" "218.9" "259.1" "229.5" "229.8" "270.4" "219.6" "264.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "662430967221413337" "False" "High" "IsMasterProtein" "Q8N264" "Rho GTPase-activating protein 24 OS=Homo sapiens OX=9606 GN=ARHGAP24 PE=1 SV=2" "0.000" "False" "15.501" "6" "4" "5" "4" "748" "84.2" "6.67" "17.19" "4" "stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "83478" "ENSG00000138639" "ARHGAP24" "hsa:83478; Q4KMG1; Q6ZNV3; Q86TI5; Q86WE4; Q8N264; Q9H0T6" "Nephrotic syndrome" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "0.674" "1.045" "1.805" "0.873" "1.176" "1.054" "1.261" "1.241" "0.790" "20.9" "14.1" "21.8" "37.7" "18.2" "24.5" "22.0" "26.3" "25.9" "16.5" "" "" "" "" "" "" "" "" "" "" "20.9" "11.9" "13.8" "27.5" "14.9" "19.0" "17.0" "22.6" "20.2" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "High" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.000" "False" "15.499" "6" "6" "6" "6" "1193" "134.3" "5.00" "13.95" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "0.981" "0.670" "0.973" "1.016" "0.815" "1.107" "1.076" "0.715" "0.938" "206.0" "202.1" "138.2" "200.5" "209.4" "168.0" "228.1" "221.6" "147.2" "193.3" "" "" "" "" "" "" "" "" "" "" "206.0" "171.0" "87.4" "146.2" "171.6" "130.5" "175.8" "190.5" "114.9" "173.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-771583783129928248" "False" "High" "IsMasterProtein" "P35869" "Aryl hydrocarbon receptor OS=Homo sapiens OX=9606 GN=AHR PE=1 SV=2" "0.000" "False" "15.470" "5" "4" "4" "4" "848" "96.1" "6.38" "14.80" "4" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf08447" "196" "ENSG00000106546" "AHR" "A4D130; hsa:196; P35869; Q13728; Q13803; Q13804" "Adipogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Cannabinoid receptor signaling; Development and heterogeneity of the ILC family; Male infertility; Prostaglandin signaling; Th17 cell differentiation pathway" "PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling" "14" "0" "1.036" "0.791" "0.966" "0.969" "0.848" "0.875" "0.926" "0.767" "0.951" "333.2" "345.0" "263.4" "321.9" "322.8" "282.6" "291.4" "308.6" "255.5" "316.9" "" "" "" "" "" "" "" "" "" "" "333.2" "291.9" "166.5" "234.7" "264.5" "219.5" "224.6" "265.3" "199.4" "284.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "15.469" "7" "3" "4" "3" "538" "60.6" "7.24" "15.27" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "1.146" "0.878" "1.002" "1.124" "0.959" "0.999" "0.944" "1.071" "1.070" "114.5" "131.3" "100.5" "114.7" "128.8" "109.9" "114.4" "108.1" "122.7" "122.6" "" "" "" "" "" "" "" "" "" "" "114.5" "111.1" "63.6" "83.7" "105.5" "85.3" "88.2" "93.0" "95.8" "110.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "15.463" "21" "4" "4" "4" "206" "21.2" "4.55" "11.32" "4" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "TNF-alpha signaling pathway" "" "1" "0" "0.987" "0.821" "1.274" "1.085" "1.111" "1.159" "1.220" "0.984" "1.036" "124.2" "122.6" "102.0" "158.3" "134.8" "138.1" "144.0" "151.6" "122.3" "128.7" "" "" "" "" "" "" "" "" "" "" "124.2" "103.7" "64.5" "115.4" "110.4" "107.2" "111.0" "130.4" "95.4" "115.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "15.459" "3" "5" "6" "5" "2243" "254.3" "6.74" "14.56" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "" "Neutrophil degranulation" "1" "0" "0.898" "0.796" "0.943" "0.867" "0.916" "0.955" "0.927" "0.922" "0.917" "117.8" "105.7" "93.7" "111.1" "102.1" "107.9" "112.5" "109.2" "108.6" "108.0" "" "" "" "" "" "" "" "" "" "" "117.8" "89.4" "59.3" "81.0" "83.6" "83.8" "86.7" "93.9" "84.8" "97.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "15.446" "30" "4" "5" "4" "163" "17.2" "9.16" "18.82" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "" "RHOD GTPase cycle" "1" "0" "1.129" "1.223" "1.162" "0.935" "1.191" "1.116" "1.042" "1.161" "1.059" "77.1" "87.0" "94.2" "89.5" "72.1" "91.8" "86.0" "80.3" "89.5" "81.6" "" "" "" "" "" "" "" "" "" "" "77.1" "73.6" "59.6" "65.3" "59.1" "71.3" "66.3" "69.0" "69.9" "73.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "15.442" "12" "5" "6" "3" "400" "44.4" "6.55" "18.59" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "88" "0" "0.936" "1.108" "1.127" "0.885" "1.065" "0.960" "0.938" "1.069" "1.010" "226.9" "212.3" "251.5" "255.7" "200.8" "241.8" "217.8" "212.9" "242.6" "229.3" "" "" "" "" "" "" "" "" "" "" "226.9" "179.6" "159.0" "186.5" "164.5" "187.7" "167.9" "183.1" "189.4" "206.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "15.439" "12" "4" "10" "4" "253" "29.8" "9.06" "30.87" "4" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.960" "1.049" "0.969" "0.972" "1.055" "1.182" "0.954" "0.992" "0.908" "801.2" "769.2" "840.2" "776.6" "778.8" "845.1" "947.1" "764.0" "794.4" "727.9" "" "" "" "" "" "" "" "" "" "" "801.2" "650.8" "531.3" "566.3" "638.0" "656.3" "730.0" "656.9" "620.1" "654.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "15.431" "7" "4" "4" "4" "786" "87.9" "7.99" "13.71" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "" "Mitochondrial RNA degradation" "1" "0" "0.748" "1.013" "0.762" "0.703" "0.758" "0.710" "0.696" "0.690" "0.676" "128.5" "96.1" "130.1" "98.0" "90.4" "97.4" "91.2" "89.4" "88.7" "86.9" "" "" "" "" "" "" "" "" "" "" "128.5" "81.3" "82.3" "71.4" "74.1" "75.6" "70.3" "76.8" "69.2" "78.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "15.424" "8" "5" "5" "4" "797" "87.2" "5.36" "15.87" "5" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "1.009" "1.074" "1.100" "1.146" "1.040" "1.068" "1.133" "1.105" "0.967" "80.3" "81.0" "86.3" "88.3" "92.0" "83.5" "85.8" "91.0" "88.7" "77.6" "" "" "" "" "" "" "" "" "" "" "80.3" "68.5" "54.6" "64.4" "75.4" "64.8" "66.1" "78.2" "69.3" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524352490741382419" "False" "High" "IsMasterProtein" "O14972" "Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1" "0.000" "False" "15.422" "12" "3" "3" "3" "297" "33.0" "7.68" "11.53" "3" "transport" "other cytoplasmic organelle" "" "Pf03643" "10311" "ENSG00000157538" "VPS26C" "B2R6T8; B7Z6B1; D3DSH4; hsa:10311; O14972; Q2TAY6" "" "" "0" "0" "0.941" "1.095" "1.049" "1.128" "0.968" "1.148" "1.071" "0.874" "1.137" "88.9" "83.6" "97.3" "93.2" "100.2" "86.0" "102.0" "95.2" "77.7" "101.0" "" "" "" "" "" "" "" "" "" "" "88.9" "70.7" "61.5" "68.0" "82.1" "66.8" "78.6" "81.8" "60.6" "90.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "High" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.000" "False" "15.421" "5" "4" "5" "4" "851" "98.7" "5.11" "18.65" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "0.934" "1.519" "1.101" "1.124" "1.603" "1.011" "0.963" "1.564" "1.110" "184.3" "172.1" "279.9" "202.8" "207.1" "295.4" "186.3" "177.5" "288.1" "204.5" "" "" "" "" "" "" "" "" "" "" "184.3" "145.6" "177.0" "147.9" "169.6" "229.4" "143.6" "152.6" "224.9" "183.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "High" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.000" "False" "15.416" "5" "4" "5" "4" "764" "89.4" "5.81" "15.38" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "Ectoderm differentiation" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "6" "0" "1.078" "1.709" "1.069" "1.157" "1.767" "1.053" "1.097" "1.724" "1.316" "160.9" "173.4" "275.0" "171.9" "186.1" "284.3" "169.4" "176.5" "277.3" "211.7" "" "" "" "" "" "" "" "" "" "" "160.9" "146.7" "173.9" "125.3" "152.5" "220.8" "130.6" "151.7" "216.4" "190.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "High" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.000" "False" "15.414" "15" "4" "6" "4" "257" "29.8" "10.48" "17.93" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.993" "0.935" "0.956" "0.973" "0.949" "0.945" "0.961" "0.939" "0.957" "622.3" "618.2" "581.8" "595.1" "605.3" "590.8" "588.3" "598.0" "584.3" "595.4" "" "" "" "" "" "" "" "" "" "" "622.3" "523.0" "367.8" "433.9" "495.9" "458.8" "453.5" "514.1" "456.1" "535.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "15.407" "7" "4" "4" "4" "703" "76.2" "6.48" "15.99" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8632288723347516488" "False" "High" "IsMasterProtein" "Q03013" "Glutathione S-transferase Mu 4 OS=Homo sapiens OX=9606 GN=GSTM4 PE=1 SV=3" "0.000" "False" "15.406" "18" "4" "6" "1" "218" "25.5" "5.90" "16.72" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2948" "ENSG00000168765" "GSTM4" "A8K765; hsa:2948; Q03013; Q05465; Q32NC1; Q4JNT8; Q6FH87" "Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)" "5" "0" "1.015" "0.904" "1.074" "1.069" "0.916" "1.125" "1.066" "0.950" "0.999" "109.9" "111.5" "99.3" "118.0" "117.5" "100.7" "123.7" "117.2" "104.4" "109.8" "" "" "" "" "" "" "" "" "" "" "109.9" "94.3" "62.8" "86.1" "96.2" "78.2" "95.3" "100.7" "81.5" "98.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531789863272175239" "False" "High" "IsMasterProtein" "Q9BU89" "Deoxyhypusine hydroxylase OS=Homo sapiens OX=9606 GN=DOHH PE=1 SV=1" "0.000" "False" "15.395" "9" "2" "4" "2" "302" "32.9" "4.83" "10.46" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf13646" "83475" "ENSG00000129932" "DOHH" "O75265; Q9BU89" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.128" "1.283" "1.289" "1.363" "1.148" "1.354" "1.420" "1.554" "1.255" "18.5" "20.9" "23.8" "23.9" "25.3" "21.3" "25.1" "26.3" "28.8" "23.3" "" "" "" "" "" "" "" "" "" "" "18.5" "17.7" "15.0" "17.4" "20.7" "16.5" "19.3" "22.6" "22.5" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "15.391" "4" "7" "7" "7" "1272" "147.7" "5.69" "21.16" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "1.050" "1.068" "0.999" "0.979" "0.998" "0.923" "0.990" "0.913" "0.994" "287.7" "302.3" "307.4" "287.3" "281.8" "287.2" "265.6" "284.8" "262.8" "285.9" "" "" "" "" "" "" "" "" "" "" "287.7" "255.7" "194.3" "209.5" "230.9" "223.0" "204.7" "244.8" "205.2" "257.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4110567019566568697" "False" "High" "IsMasterProtein" "Q9P0U4" "CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2" "0.000" "False" "15.381" "9" "6" "7" "6" "656" "75.7" "8.24" "17.24" "6" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf02008, Pf12269" "30827" "ENSG00000154832" "CXXC1" "B2RC03; hsa:30827; Q8N2W4; Q96BC8; Q9P0U4; Q9P2V7" "Male infertility" "Formation of WDR5-containing histone-modifying complexes; XBP1(S) activates chaperone genes" "3" "0" "1.239" "0.852" "1.227" "1.063" "0.857" "1.115" "0.988" "0.878" "1.029" "175.3" "217.2" "149.4" "215.1" "186.3" "150.3" "195.6" "173.1" "154.0" "180.4" "" "" "" "" "" "" "" "" "" "" "175.3" "183.8" "94.5" "156.8" "152.6" "116.7" "150.7" "148.9" "120.2" "162.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7142901860351875660" "False" "High" "IsMasterProtein" "Q8WXE0" "Caskin-2 OS=Homo sapiens OX=9606 GN=CASKIN2 PE=1 SV=2" "0.000" "False" "15.354" "4" "5" "6" "4" "1202" "126.7" "7.09" "19.17" "5" "" "other cell component" "" "Pf00536, Pf07653, Pf12796, Pf16600, Pf16632, Pf16907" "57513" "ENSG00000177303" "CASKIN2" "B4DTT3; B7Z9H1; hsa:57513; Q7LG69; Q8WXE0; Q9ULT1" "" "" "0" "0" "1.062" "0.799" "1.056" "0.880" "0.959" "1.196" "1.107" "0.847" "0.904" "148.3" "157.5" "118.6" "156.6" "130.5" "142.2" "177.3" "164.2" "125.6" "134.1" "" "" "" "" "" "" "" "" "" "" "148.3" "133.3" "75.0" "114.2" "106.9" "110.5" "136.7" "141.2" "98.1" "120.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.000" "False" "15.354" "6" "4" "4" "4" "615" "68.1" "7.55" "13.37" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial Fatty Acid Beta-Oxidation" "3" "0" "0.945" "0.879" "0.997" "1.014" "0.881" "0.916" "0.996" "0.910" "0.902" "319.0" "301.6" "280.6" "318.0" "323.6" "280.9" "292.3" "317.7" "290.3" "287.7" "" "" "" "" "" "" "" "" "" "" "319.0" "255.2" "177.4" "231.9" "265.1" "218.2" "225.3" "273.1" "226.6" "258.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "15.336" "17" "4" "4" "4" "340" "36.5" "5.41" "10.97" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.100" "1.064" "1.170" "1.210" "1.115" "1.418" "0.988" "1.201" "1.041" "60.0" "66.0" "63.8" "70.1" "72.6" "66.9" "85.0" "59.2" "72.0" "62.4" "" "" "" "" "" "" "" "" "" "" "60.0" "55.8" "40.4" "51.1" "59.5" "51.9" "65.5" "50.9" "56.2" "56.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "15.332" "12" "4" "4" "4" "380" "44.6" "7.53" "13.86" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.149" "1.135" "1.009" "1.192" "1.101" "1.055" "1.108" "1.220" "1.083" "173.9" "199.8" "197.3" "175.4" "207.2" "191.5" "183.6" "192.7" "212.2" "188.4" "" "" "" "" "" "" "" "" "" "" "173.9" "169.0" "124.8" "127.9" "169.8" "148.8" "141.5" "165.7" "165.6" "169.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "15.321" "7" "2" "4" "2" "356" "39.4" "7.20" "11.69" "2" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.010" "0.962" "0.944" "1.024" "0.972" "0.925" "0.977" "0.931" "1.020" "182.8" "184.6" "175.8" "172.6" "187.2" "177.6" "169.0" "178.6" "170.1" "186.5" "" "" "" "" "" "" "" "" "" "" "182.8" "156.2" "111.2" "125.8" "153.3" "137.9" "130.3" "153.6" "132.8" "167.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "15.320" "16" "3" "3" "3" "265" "30.5" "6.33" "11.99" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "" "mRNA Splicing - Major Pathway" "1" "0" "0.909" "1.748" "1.764" "1.121" "1.106" "1.577" "1.170" "0.817" "1.210" "11.3" "10.3" "19.8" "20.0" "12.7" "12.5" "17.9" "13.3" "9.3" "13.7" "" "" "" "" "" "" "" "" "" "" "11.3" "8.7" "12.5" "14.6" "10.4" "9.7" "13.8" "11.4" "7.2" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "15.303" "7" "5" "5" "4" "653" "73.4" "4.75" "15.94" "5" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.072" "1.068" "1.122" "1.121" "1.086" "1.162" "1.050" "1.028" "1.012" "121.8" "130.6" "130.1" "136.6" "136.5" "132.3" "141.6" "128.0" "125.3" "123.3" "" "" "" "" "" "" "" "" "" "" "121.8" "110.5" "82.3" "99.6" "111.9" "102.7" "109.1" "110.0" "97.8" "110.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6526691587198802025" "False" "High" "IsMasterProtein" "P59780" "AP-3 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP3S2 PE=1 SV=1" "0.000" "False" "15.301" "17" "3" "3" "3" "193" "22.0" "5.22" "12.31" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "10239" "ENSG00000157823" "AP3S2" "B2R677; B4DGQ3; hsa:10239; O09077; O09149; P59780; Q53H83; Q99589" "" "" "0" "0" "0.973" "0.839" "1.056" "0.985" "0.966" "1.025" "0.954" "0.878" "0.927" "135.4" "131.8" "113.5" "143.0" "133.3" "130.8" "138.8" "129.2" "118.9" "125.5" "" "" "" "" "" "" "" "" "" "" "135.4" "111.5" "71.8" "104.3" "109.2" "101.6" "107.0" "111.1" "92.8" "112.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6931862210339099933" "False" "High" "IsMasterProtein" "Q9H1B7" "Probable E3 ubiquitin-protein ligase IRF2BPL OS=Homo sapiens OX=9606 GN=IRF2BPL PE=1 SV=1" "0.000" "False" "15.290" "6" "5" "5" "3" "796" "82.6" "8.24" "15.17" "5" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "64207" "ENSG00000119669" "IRF2BPL" "hsa:64207; Q8NDQ2; Q96JG2; Q9H1B7; Q9H3I7" "" "" "0" "0" "0.941" "0.952" "1.044" "0.972" "0.901" "0.926" "0.978" "1.014" "0.947" "149.2" "140.4" "142.0" "155.7" "145.1" "134.5" "138.3" "145.9" "151.3" "141.4" "" "" "" "" "" "" "" "" "" "" "149.2" "118.7" "89.8" "113.5" "118.9" "104.4" "106.6" "125.5" "118.1" "127.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "15.281" "11" "5" "11" "5" "348" "38.8" "4.91" "29.07" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.110" "1.029" "1.104" "1.086" "0.953" "1.004" "1.061" "0.979" "1.059" "170.8" "189.6" "175.8" "188.5" "185.5" "162.8" "171.5" "181.2" "167.2" "180.8" "" "" "" "" "" "" "" "" "" "" "170.8" "160.4" "111.2" "137.5" "152.0" "126.5" "132.2" "155.8" "130.5" "162.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "15.244" "6" "3" "4" "3" "504" "55.7" "8.75" "15.03" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "VEGFA-VEGFR2 signaling; mRNA processing" "SRP-dependent cotranslational protein targeting to membrane" "3" "0" "1.064" "1.108" "1.123" "1.109" "1.088" "1.123" "1.115" "1.217" "1.019" "144.0" "153.2" "159.6" "161.7" "159.7" "156.6" "161.8" "160.5" "175.3" "146.7" "" "" "" "" "" "" "" "" "" "" "144.0" "129.6" "100.9" "117.9" "130.8" "121.6" "124.7" "138.0" "136.9" "131.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163608174618773486" "False" "High" "IsMasterProtein" "Q5SXM2" "snRNA-activating protein complex subunit 4 OS=Homo sapiens OX=9606 GN=SNAPC4 PE=1 SV=1" "0.000" "False" "15.229" "5" "6" "6" "5" "1469" "159.3" "8.28" "18.32" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13921" "6621" "ENSG00000165684" "SNAPC4" "hsa:6621; Q5SXM2; Q9Y6P7" "" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "3" "0" "0.885" "0.741" "0.830" "0.979" "0.892" "1.053" "0.850" "0.923" "0.829" "97.1" "86.0" "72.0" "80.6" "95.1" "86.6" "102.3" "82.5" "89.6" "80.5" "" "" "" "" "" "" "" "" "" "" "97.1" "72.7" "45.5" "58.8" "77.9" "67.2" "78.8" "71.0" "69.9" "72.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "15.227" "9" "3" "6" "3" "452" "47.1" "4.82" "17.25" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "" "Golgi Cisternae Pericentriolar Stack Reorganization" "1" "0" "0.931" "0.893" "0.936" "1.158" "1.062" "1.119" "0.971" "1.052" "0.983" "67.0" "62.3" "59.8" "62.7" "77.5" "71.1" "74.9" "65.0" "70.4" "65.8" "" "" "" "" "" "" "" "" "" "" "67.0" "52.7" "37.8" "45.7" "63.5" "55.2" "57.8" "55.9" "55.0" "59.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2963381124708492524" "False" "High" "IsMasterProtein" "Q5JTH9" "RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2" "0.000" "False" "15.219" "5" "6" "6" "5" "1297" "143.6" "8.75" "17.74" "6" "RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf08161" "23223" "ENSG00000052749" "RRP12" "B4DK00; E9PCK7; hsa:23223; Q5JTH8; Q5JTH9; Q69YK4; Q96E87; Q9BUH3; Q9Y4C7" "" "" "0" "0" "1.029" "0.765" "0.990" "0.989" "0.800" "1.033" "0.963" "0.829" "0.922" "328.6" "338.2" "251.2" "325.3" "325.1" "262.7" "339.5" "316.4" "272.4" "302.9" "" "" "" "" "" "" "" "" "" "" "328.6" "286.1" "158.8" "237.2" "266.4" "204.0" "261.7" "272.1" "212.7" "272.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "15.210" "8" "3" "4" "3" "379" "44.4" "5.08" "12.91" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "9" "0" "1.167" "1.333" "1.226" "1.378" "1.551" "1.155" "1.182" "1.366" "1.293" "68.4" "79.8" "91.1" "83.8" "94.2" "106.0" "78.9" "80.8" "93.4" "88.4" "" "" "" "" "" "" "" "" "" "" "68.4" "67.5" "57.6" "61.1" "77.2" "82.4" "60.8" "69.5" "72.9" "79.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "15.206" "8" "2" "3" "2" "290" "33.2" "7.44" "12.24" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "Ciliopathies" "" "1" "0" "0.947" "0.980" "1.023" "0.959" "1.045" "1.003" "1.000" "0.937" "0.940" "206.9" "195.9" "202.8" "211.7" "198.4" "216.2" "207.6" "206.9" "193.9" "194.5" "" "" "" "" "" "" "" "" "" "" "206.9" "165.7" "128.2" "154.3" "162.5" "167.9" "160.0" "177.9" "151.3" "174.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "15.201" "14" "6" "6" "6" "452" "50.9" "6.54" "16.58" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.982" "0.848" "0.989" "0.995" "0.881" "0.942" "0.881" "0.895" "1.002" "184.1" "180.9" "156.2" "182.1" "183.2" "162.3" "173.4" "162.2" "164.9" "184.5" "" "" "" "" "" "" "" "" "" "" "184.1" "153.0" "98.8" "132.7" "150.1" "126.0" "133.7" "139.5" "128.7" "165.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "15.182" "13" "3" "8" "3" "239" "27.1" "5.90" "29.38" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "10" "0" "1.036" "0.891" "1.057" "1.011" "0.879" "1.020" "0.983" "0.941" "0.987" "491.1" "508.5" "437.8" "519.0" "496.3" "431.8" "500.9" "482.9" "462.2" "484.9" "" "" "" "" "" "" "" "" "" "" "491.1" "430.2" "276.8" "378.4" "406.6" "335.3" "386.2" "415.2" "360.8" "435.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "15.137" "6" "5" "5" "5" "1017" "110.2" "4.74" "11.51" "5" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "1.018" "1.186" "1.025" "1.055" "1.173" "1.003" "1.042" "1.214" "1.093" "165.6" "168.6" "196.4" "169.8" "174.6" "194.3" "166.1" "172.6" "201.1" "181.1" "" "" "" "" "" "" "" "" "" "" "165.6" "142.7" "124.2" "123.8" "143.1" "150.9" "128.0" "148.4" "157.0" "162.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "15.086" "13" "4" "7" "4" "331" "36.9" "5.03" "18.97" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.037" "1.072" "1.022" "1.064" "0.990" "1.040" "0.913" "1.001" "1.050" "547.5" "567.5" "586.8" "559.6" "582.3" "542.1" "569.5" "499.6" "547.8" "574.8" "" "" "" "" "" "" "" "" "" "" "547.5" "480.1" "371.0" "408.0" "477.1" "421.0" "439.0" "429.6" "427.6" "516.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "15.080" "21" "2" "4" "2" "115" "13.0" "11.00" "14.89" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; SARS-CoV-2 modulates host translation machinery; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.117" "1.498" "1.183" "1.078" "1.164" "1.347" "1.357" "1.442" "1.255" "40.5" "45.3" "60.7" "47.9" "43.7" "47.1" "54.5" "55.0" "58.4" "50.8" "" "" "" "" "" "" "" "" "" "" "40.5" "38.3" "38.4" "34.9" "35.8" "36.6" "42.0" "47.2" "45.6" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.000" "False" "15.079" "13" "3" "4" "3" "275" "31.4" "4.92" "12.69" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "RNA polymerase II transcribes snRNA genes; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "1.088" "0.924" "1.182" "0.959" "0.841" "1.026" "0.940" "0.869" "1.141" "56.5" "61.4" "52.2" "66.7" "54.2" "47.5" "57.9" "53.1" "49.0" "64.4" "" "" "" "" "" "" "" "" "" "" "56.5" "52.0" "33.0" "48.7" "44.4" "36.9" "44.6" "45.6" "38.3" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "15.076" "21" "4" "7" "4" "172" "19.2" "5.40" "18.57" "4" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "0.969" "1.021" "0.970" "1.023" "1.040" "1.104" "0.984" "0.995" "1.140" "406.9" "394.3" "415.4" "394.8" "416.4" "423.2" "449.5" "400.6" "404.8" "463.8" "" "" "" "" "" "" "" "" "" "" "406.9" "333.6" "262.6" "287.9" "341.1" "328.7" "346.5" "344.4" "316.0" "417.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323681854308555372" "False" "High" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "0.000" "False" "15.056" "2" "6" "6" "6" "3046" "338.1" "6.54" "13.99" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "" "2" "0" "0.891" "0.581" "0.818" "0.936" "0.589" "0.855" "0.921" "0.606" "0.718" "152.9" "136.2" "88.8" "125.1" "143.1" "90.0" "130.7" "140.8" "92.6" "109.7" "" "" "" "" "" "" "" "" "" "" "152.9" "115.3" "56.1" "91.2" "117.2" "69.9" "100.7" "121.1" "72.3" "98.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "15.049" "25" "4" "5" "4" "138" "15.6" "7.61" "17.74" "4" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "1.127" "0.809" "1.015" "1.066" "0.797" "0.911" "0.943" "0.772" "0.911" "289.0" "325.8" "233.7" "293.2" "308.2" "230.2" "263.4" "272.5" "223.2" "263.3" "" "" "" "" "" "" "" "" "" "" "289.0" "275.6" "147.7" "213.8" "252.5" "178.8" "203.0" "234.3" "174.2" "236.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "15.046" "13" "5" "5" "5" "360" "39.6" "8.09" "11.64" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "" "Amino acids regulate mTORC1" "1" "0" "0.996" "0.825" "1.008" "0.953" "0.900" "1.040" "1.032" "0.914" "0.925" "345.8" "344.4" "285.4" "348.5" "329.6" "311.2" "359.7" "356.9" "316.0" "319.9" "" "" "" "" "" "" "" "" "" "" "345.8" "291.4" "180.5" "254.1" "270.1" "241.7" "277.3" "306.9" "246.7" "287.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "15.045" "26" "4" "4" "4" "160" "18.0" "5.01" "14.62" "4" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "0.911" "1.022" "0.935" "0.995" "1.055" "0.951" "0.969" "1.051" "1.052" "452.9" "412.4" "462.7" "423.4" "450.7" "477.9" "430.8" "438.8" "475.9" "476.3" "" "" "" "" "" "" "" "" "" "" "452.9" "348.9" "292.6" "308.7" "369.3" "371.1" "332.1" "377.3" "371.5" "428.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.000" "False" "15.018" "8" "2" "2" "2" "453" "50.9" "5.35" "9.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.245" "1.280" "1.076" "0.815" "1.190" "1.003" "1.134" "1.323" "1.258" "16.5" "20.5" "21.1" "17.7" "13.4" "19.6" "16.5" "18.7" "21.8" "20.7" "" "" "" "" "" "" "" "" "" "" "16.5" "17.3" "13.3" "12.9" "11.0" "15.2" "12.7" "16.1" "17.0" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "15.010" "12" "2" "3" "2" "205" "22.9" "4.63" "12.19" "2" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "" "Neutrophil degranulation" "1" "0" "0.876" "1.044" "1.020" "0.909" "1.125" "1.012" "0.897" "1.014" "1.027" "251.4" "220.3" "262.4" "256.5" "228.5" "282.9" "254.4" "225.6" "255.0" "258.2" "" "" "" "" "" "" "" "" "" "" "251.4" "186.3" "165.9" "187.0" "187.2" "219.7" "196.1" "194.0" "199.0" "232.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "14.961" "20" "2" "4" "2" "140" "15.0" "6.99" "12.30" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "Physico-chemical features and toxicity-associated pathways" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "3" "0" "0.997" "1.055" "0.883" "0.994" "1.087" "1.070" "1.079" "1.078" "1.017" "132.3" "131.9" "139.6" "116.8" "131.5" "143.8" "141.5" "142.7" "142.7" "134.6" "" "" "" "" "" "" "" "" "" "" "132.3" "111.6" "88.3" "85.2" "107.8" "111.6" "109.1" "122.7" "111.3" "121.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8730523960052608716" "False" "High" "IsMasterProtein" "O60879" "Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1" "0.000" "False" "14.954" "4" "5" "6" "5" "1101" "125.5" "6.58" "16.77" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "1730" "ENSG00000147202" "DIAPH2" "A6NG19; hsa:1730; O60878; O60879; Q8WX06; Q8WX48; Q9UJL2" "Primary ovarian insufficiency" "RHOF GTPase cycle" "2" "0" "0.995" "0.823" "1.115" "1.079" "1.030" "0.987" "1.021" "0.866" "0.970" "172.7" "172.0" "142.1" "192.7" "186.4" "177.9" "170.5" "176.4" "149.6" "167.5" "" "" "" "" "" "" "" "" "" "" "172.7" "145.5" "89.9" "140.5" "152.7" "138.1" "131.5" "151.7" "116.7" "150.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "14.953" "17" "2" "7" "2" "133" "15.4" "10.78" "21.14" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.804" "1.035" "0.879" "0.997" "1.064" "0.842" "1.086" "1.110" "1.036" "250.5" "201.4" "259.4" "220.1" "249.6" "266.6" "211.0" "272.0" "278.1" "259.4" "" "" "" "" "" "" "" "" "" "" "250.5" "170.4" "164.0" "160.5" "204.5" "207.0" "162.6" "233.9" "217.1" "233.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4935758421494429625" "False" "High" "IsMasterProtein" "P54277" "PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 SV=1" "0.000" "False" "14.946" "5" "5" "5" "5" "932" "105.8" "6.67" "7.96" "5" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01119, Pf02518" "5378" "ENSG00000064933" "PMS1" "D3DPI1; hsa:5378; P54277; Q4VAL4; Q5FBZ3; Q5FBZ6; Q5FBZ8" "" "" "0" "0" "1.059" "1.066" "1.327" "1.003" "1.278" "1.109" "1.055" "1.298" "0.989" "114.1" "120.8" "121.6" "151.4" "114.5" "145.8" "126.5" "120.4" "148.1" "112.9" "" "" "" "" "" "" "" "" "" "" "114.1" "102.2" "76.9" "110.4" "93.8" "113.2" "97.5" "103.5" "115.6" "101.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "14.942" "9" "4" "5" "4" "469" "51.3" "5.58" "15.65" "4" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "25" "0" "0.965" "0.767" "0.946" "0.838" "0.709" "0.869" "0.901" "0.762" "0.804" "684.7" "660.7" "525.5" "647.9" "573.7" "485.7" "594.7" "616.9" "521.9" "550.8" "" "" "" "" "" "" "" "" "" "" "684.7" "558.9" "332.3" "472.4" "470.1" "377.2" "458.4" "530.4" "407.3" "495.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "14.922" "10" "4" "5" "4" "386" "43.8" "7.20" "15.01" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Network map of SARS-CoV-2 signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "3" "0" "0.919" "0.879" "0.914" "0.932" "0.946" "1.012" "0.989" "0.843" "0.910" "468.6" "430.5" "412.1" "428.4" "436.7" "443.3" "474.4" "463.3" "394.8" "426.7" "" "" "" "" "" "" "" "" "" "" "468.6" "364.2" "260.6" "312.4" "357.8" "344.3" "365.7" "398.3" "308.2" "383.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8452919191869770403" "False" "High" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "0.000" "False" "14.898" "7" "4" "4" "3" "542" "60.0" "7.72" "14.57" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "0" "1.222" "1.023" "0.941" "1.276" "1.086" "1.331" "1.640" "0.975" "1.243" "35.6" "43.5" "36.4" "33.5" "45.4" "38.7" "47.4" "58.4" "34.7" "44.2" "" "" "" "" "" "" "" "" "" "" "35.6" "36.8" "23.0" "24.4" "37.2" "30.0" "36.5" "50.2" "27.1" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.000" "False" "14.897" "6" "5" "6" "5" "772" "87.2" "9.57" "18.27" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "1.008" "1.175" "0.944" "1.056" "1.269" "1.136" "1.065" "1.350" "1.154" "103.3" "104.2" "121.5" "97.5" "109.1" "131.1" "117.4" "110.1" "139.5" "119.3" "" "" "" "" "" "" "" "" "" "" "103.3" "88.2" "76.8" "71.1" "89.4" "101.8" "90.5" "94.7" "108.9" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "High" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.000" "False" "14.890" "9" "4" "4" "4" "570" "63.4" "7.36" "12.49" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "1.063" "0.967" "0.858" "0.990" "1.010" "1.069" "0.971" "0.814" "0.870" "118.4" "125.9" "114.4" "101.6" "117.2" "119.6" "126.5" "114.9" "96.4" "102.9" "" "" "" "" "" "" "" "" "" "" "118.4" "106.5" "72.3" "74.1" "96.0" "92.9" "97.5" "98.8" "75.2" "92.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "14.887" "4" "3" "3" "3" "903" "97.3" "4.94" "10.55" "3" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "G protein signaling pathways" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "3" "0" "0.951" "0.957" "1.086" "1.151" "1.175" "1.099" "1.127" "1.100" "1.006" "79.9" "76.0" "76.5" "86.7" "92.0" "93.8" "87.8" "90.0" "87.9" "80.3" "" "" "" "" "" "" "" "" "" "" "79.9" "64.3" "48.4" "63.2" "75.3" "72.9" "67.7" "77.4" "68.6" "72.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "14.886" "7" "4" "5" "4" "535" "59.8" "5.05" "14.05" "4" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "1.149" "0.762" "1.037" "1.211" "1.117" "1.041" "1.042" "0.899" "1.004" "85.3" "98.0" "65.0" "88.5" "103.2" "95.3" "88.8" "88.9" "76.7" "85.6" "" "" "" "" "" "" "" "" "" "" "85.3" "82.9" "41.1" "64.5" "84.6" "74.0" "68.4" "76.4" "59.9" "77.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "14.885" "5" "3" "3" "3" "695" "76.1" "8.70" "10.41" "3" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "0.974" "1.489" "1.011" "1.047" "1.493" "1.044" "0.977" "1.549" "1.092" "200.7" "195.5" "298.7" "202.9" "210.0" "299.6" "209.5" "196.1" "310.8" "219.2" "" "" "" "" "" "" "" "" "" "" "200.7" "165.4" "188.9" "147.9" "172.1" "232.6" "161.5" "168.6" "242.6" "197.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703372283530206058" "False" "High" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "0.000" "False" "14.864" "29" "2" "3" "2" "96" "10.9" "7.25" "10.02" "2" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "Intraflagellar transport" "4" "0" "1.032" "0.982" "1.003" "1.116" "1.076" "1.279" "1.090" "0.954" "1.070" "144.0" "148.5" "141.3" "144.4" "160.6" "155.0" "184.1" "156.9" "137.4" "154.0" "" "" "" "" "" "" "" "" "" "" "144.0" "125.7" "89.3" "105.3" "131.6" "120.3" "141.9" "134.9" "107.2" "138.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "14.854" "17" "5" "7" "5" "237" "26.3" "7.84" "21.21" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "1.082" "1.012" "1.023" "1.074" "0.996" "1.029" "1.019" "1.017" "0.992" "487.1" "526.8" "493.1" "498.4" "523.3" "485.3" "501.4" "496.1" "495.4" "483.1" "" "" "" "" "" "" "" "" "" "" "487.1" "445.7" "311.8" "363.4" "428.7" "376.9" "386.5" "426.6" "386.7" "434.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.000" "False" "14.852" "2" "3" "3" "3" "1512" "164.4" "7.74" "12.60" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "MyD88:MAL(TIRAP) cascade initiated on plasma membrane; FCERI mediated MAPK activation; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "32" "0" "1.042" "1.008" "1.083" "1.059" "1.054" "1.174" "0.993" "1.041" "1.052" "275.7" "287.2" "278.0" "298.5" "291.9" "290.5" "323.6" "273.7" "287.1" "289.9" "" "" "" "" "" "" "" "" "" "" "275.7" "243.0" "175.8" "217.7" "239.2" "225.6" "249.5" "235.3" "224.1" "260.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "14.842" "11" "3" "6" "3" "285" "33.0" "5.17" "19.80" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "0.860" "0.593" "0.875" "1.009" "0.740" "0.986" "0.908" "0.830" "0.899" "74.0" "63.6" "43.9" "64.7" "74.6" "54.7" "73.0" "67.2" "61.4" "66.5" "" "" "" "" "" "" "" "" "" "" "74.0" "53.8" "27.7" "47.2" "61.2" "42.5" "56.2" "57.8" "47.9" "59.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "14.839" "16" "5" "6" "5" "313" "35.1" "7.69" "18.88" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.916" "0.959" "0.964" "0.897" "0.928" "0.942" "0.957" "0.956" "0.898" "380.8" "349.0" "365.4" "367.0" "341.7" "353.6" "358.6" "364.6" "364.2" "342.0" "" "" "" "" "" "" "" "" "" "" "380.8" "295.3" "231.0" "267.6" "279.9" "274.6" "276.4" "313.5" "284.3" "307.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "14.816" "30" "2" "3" "2" "117" "12.2" "4.92" "16.34" "2" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "16" "0" "0.941" "0.849" "1.090" "1.012" "0.808" "1.018" "0.887" "0.892" "0.991" "88.7" "83.5" "75.3" "96.7" "89.7" "71.6" "90.3" "78.7" "79.2" "87.9" "" "" "" "" "" "" "" "" "" "" "88.7" "70.6" "47.6" "70.5" "73.5" "55.6" "69.6" "67.7" "61.8" "79.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "14.804" "17" "3" "6" "3" "170" "19.3" "4.81" "20.29" "3" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "15" "0" "1.007" "1.020" "1.109" "0.993" "1.053" "1.162" "1.011" "1.062" "1.009" "209.1" "210.5" "213.4" "232.0" "207.6" "220.3" "243.1" "211.5" "222.2" "211.1" "" "" "" "" "" "" "" "" "" "" "209.1" "178.1" "134.9" "169.2" "170.1" "171.0" "187.4" "181.9" "173.4" "189.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "14.802" "10" "4" "6" "4" "414" "46.4" "4.75" "17.00" "4" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "0.926" "0.792" "0.905" "0.985" "0.937" "0.967" "0.965" "0.878" "0.980" "329.9" "305.6" "261.3" "298.6" "325.0" "309.1" "318.9" "318.4" "289.8" "323.3" "" "" "" "" "" "" "" "" "" "" "329.9" "258.5" "165.2" "217.7" "266.2" "240.1" "245.9" "273.7" "226.2" "290.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "14.802" "18" "4" "5" "4" "212" "23.2" "6.87" "14.04" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.049" "0.952" "0.973" "1.076" "1.006" "1.111" "1.031" "0.923" "0.843" "171.0" "179.4" "162.7" "166.3" "184.0" "172.1" "190.0" "176.3" "157.8" "144.2" "" "" "" "" "" "" "" "" "" "" "171.0" "151.8" "102.9" "121.3" "150.7" "133.7" "146.4" "151.6" "123.2" "129.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "14.797" "18" "3" "4" "2" "142" "16.7" "5.29" "15.99" "3" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "0" "1.154" "1.105" "1.226" "1.148" "1.072" "1.278" "0.975" "1.150" "1.103" "78.1" "90.2" "86.3" "95.7" "89.7" "83.8" "99.8" "76.2" "89.8" "86.2" "" "" "" "" "" "" "" "" "" "" "78.1" "76.3" "54.6" "69.8" "73.5" "65.0" "77.0" "65.5" "70.1" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "14.792" "7" "4" "8" "4" "475" "53.5" "9.09" "21.54" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "mRNA Splicing - Major Pathway; Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.125" "1.563" "1.042" "1.020" "1.330" "1.060" "1.044" "1.348" "1.044" "114.9" "129.2" "179.5" "119.6" "117.1" "152.7" "121.7" "119.9" "154.8" "119.9" "" "" "" "" "" "" "" "" "" "" "114.9" "109.3" "113.5" "87.2" "95.9" "118.6" "93.8" "103.1" "120.8" "107.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "14.767" "11" "4" "4" "4" "480" "50.4" "9.63" "10.73" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "" "mRNA Splicing - Major Pathway" "1" "0" "1.034" "1.182" "1.105" "1.130" "1.180" "1.245" "0.913" "1.138" "1.050" "62.9" "65.0" "74.4" "69.5" "71.1" "74.2" "78.3" "57.5" "71.6" "66.0" "" "" "" "" "" "" "" "" "" "" "62.9" "55.0" "47.0" "50.7" "58.3" "57.7" "60.4" "49.4" "55.9" "59.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.000" "False" "14.762" "8" "4" "5" "4" "596" "63.9" "8.21" "16.96" "4" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Extracellular vesicles in the crosstalk of cardiac cells" "Neurexins and neuroligins" "2" "0" "1.154" "1.017" "1.239" "1.214" "1.110" "1.212" "1.105" "1.221" "1.132" "95.9" "110.7" "97.5" "118.8" "116.3" "106.4" "116.2" "105.9" "117.0" "108.5" "" "" "" "" "" "" "" "" "" "" "95.9" "93.6" "61.6" "86.6" "95.3" "82.7" "89.6" "91.1" "91.3" "97.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "14.714" "7" "4" "5" "4" "747" "81.6" "4.67" "17.85" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "Regulation of HSF1-mediated heat shock response; Heme signaling; Circadian Clock; SIRT1 negatively regulates rRNA expression; Regulation of FOXO transcriptional activity by acetylation" "27" "0" "1.101" "0.917" "1.151" "1.044" "0.883" "1.129" "1.076" "1.040" "1.014" "259.9" "286.2" "238.3" "299.1" "271.2" "229.5" "293.3" "279.7" "270.3" "263.6" "" "" "" "" "" "" "" "" "" "" "259.9" "242.1" "150.7" "218.1" "222.2" "178.2" "226.1" "240.5" "210.9" "237.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "14.705" "7" "2" "4" "1" "376" "42.3" "6.40" "15.60" "2" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "" "Neutrophil degranulation; MHC class II antigen presentation" "2" "0" "1.039" "0.813" "1.040" "0.959" "0.883" "0.874" "1.031" "1.207" "0.878" "60.8" "63.1" "49.4" "63.2" "58.3" "53.7" "53.1" "62.7" "73.4" "53.4" "" "" "" "" "" "" "" "" "" "" "60.8" "53.4" "31.2" "46.1" "47.8" "41.7" "40.9" "53.9" "57.3" "48.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "14.700" "23" "6" "6" "6" "208" "24.5" "6.80" "17.77" "6" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.961" "1.076" "0.918" "1.027" "1.031" "1.021" "0.985" "1.017" "1.040" "429.1" "412.2" "461.5" "393.7" "440.5" "442.5" "438.1" "422.7" "436.2" "446.2" "" "" "" "" "" "" "" "" "" "" "429.1" "348.7" "291.8" "287.1" "360.9" "343.6" "337.7" "363.5" "340.4" "401.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654723519218057862" "False" "High" "IsMasterProtein" "Q9BXB5" "Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2" "0.000" "False" "14.695" "4" "2" "3" "2" "764" "83.9" "8.31" "13.49" "2" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114884" "ENSG00000144645" "OSBPL10" "B4E212; hsa:114884; Q9BTU5; Q9BXB5" "" "Acyl chain remodelling of PS" "1" "0" "0.937" "0.836" "1.141" "1.086" "0.963" "1.157" "1.066" "0.994" "1.082" "75.1" "70.3" "62.8" "85.7" "81.6" "72.4" "86.9" "80.0" "74.7" "81.3" "" "" "" "" "" "" "" "" "" "" "75.1" "59.5" "39.7" "62.5" "66.8" "56.2" "67.0" "68.8" "58.3" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "High" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.000" "False" "14.670" "3" "5" "5" "5" "2073" "237.5" "7.74" "13.85" "5" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "3" "0" "0.992" "0.971" "0.958" "0.893" "0.943" "0.980" "0.958" "0.907" "0.895" "196.2" "194.6" "190.5" "188.0" "175.1" "185.0" "192.3" "187.9" "178.0" "175.6" "" "" "" "" "" "" "" "" "" "" "196.2" "164.6" "120.4" "137.1" "143.5" "143.6" "148.3" "161.5" "138.9" "157.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302627442796740728" "False" "High" "IsMasterProtein" "Q15771" "Ras-related protein Rab-30 OS=Homo sapiens OX=9606 GN=RAB30 PE=1 SV=2" "0.000" "False" "14.662" "13" "3" "9" "2" "203" "23.0" "4.97" "28.25" "3" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "27314" "ENSG00000137502" "RAB30" "hsa:27314; Q15771; Q6FGK1; Q6MZH2; Q96CI8" "" "Intra-Golgi traffic; RAB geranylgeranylation" "2" "0" "1.002" "1.067" "0.869" "1.006" "1.204" "0.983" "0.976" "1.076" "1.087" "126.4" "126.7" "134.8" "109.9" "127.2" "152.2" "124.3" "123.4" "136.0" "137.4" "" "" "" "" "" "" "" "" "" "" "126.4" "107.2" "85.3" "80.1" "104.2" "118.2" "95.8" "106.1" "106.2" "123.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "14.658" "9" "3" "5" "3" "356" "40.5" "8.34" "20.02" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.094" "0.846" "0.980" "1.056" "0.942" "1.086" "1.010" "0.914" "1.055" "247.2" "270.3" "209.1" "242.3" "260.9" "232.9" "268.4" "249.8" "226.0" "260.9" "" "" "" "" "" "" "" "" "" "" "247.2" "228.7" "132.2" "176.7" "213.8" "180.8" "206.9" "214.7" "176.4" "234.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "14.652" "14" "5" "6" "5" "327" "35.9" "7.74" "20.31" "5" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "0.999" "1.050" "0.974" "1.016" "1.061" "1.057" "0.998" "1.058" "1.042" "358.1" "357.9" "376.2" "348.8" "363.7" "380.1" "378.6" "357.4" "378.8" "373.2" "" "" "" "" "" "" "" "" "" "" "358.1" "302.8" "237.9" "254.3" "298.0" "295.2" "291.8" "307.3" "295.7" "335.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8155016399758939464" "False" "High" "IsMasterProtein" "Q9UNS1" "Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2" "0.000" "False" "14.651" "3" "4" "4" "4" "1208" "138.6" "5.40" "12.33" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04821, Pf05029" "8914" "ENSG00000111602" "TIMELESS" "B2ZAV0; hsa:8914; O94802; Q86VM1; Q8IWH3; Q9UNS1" "" "Processing of DNA double-strand break ends" "1" "0" "1.016" "0.735" "1.001" "1.091" "0.777" "1.030" "1.004" "0.717" "0.845" "207.2" "210.4" "152.3" "207.4" "226.1" "161.0" "213.5" "208.1" "148.5" "175.0" "" "" "" "" "" "" "" "" "" "" "207.2" "178.0" "96.3" "151.2" "185.3" "125.1" "164.6" "178.9" "115.9" "157.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407344682093019997" "False" "High" "IsMasterProtein" "Q53GL0" "Pleckstrin homology domain-containing family O member 1 OS=Homo sapiens OX=9606 GN=PLEKHO1 PE=1 SV=2" "0.000" "False" "14.651" "16" "6" "6" "6" "409" "46.2" "8.82" "13.84" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf00169" "51177" "ENSG00000023902" "PLEKHO1" "hsa:51177; Q336K5; Q53GL0; Q8IZ51; Q9NRV3; Q9UL48" "" "" "0" "0" "1.057" "0.983" "1.062" "1.078" "1.040" "1.073" "1.116" "1.018" "1.086" "191.9" "202.9" "188.5" "203.7" "206.9" "199.5" "205.8" "214.1" "195.3" "208.4" "" "" "" "" "" "" "" "" "" "" "191.9" "171.7" "119.2" "148.5" "169.5" "154.9" "158.6" "184.1" "152.5" "187.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "14.632" "6" "4" "4" "4" "556" "61.9" "8.54" "12.00" "4" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "" "2" "0" "1.063" "1.093" "0.980" "1.091" "1.113" "1.116" "1.078" "1.121" "1.038" "325.6" "346.2" "355.7" "319.0" "355.1" "362.3" "363.5" "350.9" "364.9" "338.1" "" "" "" "" "" "" "" "" "" "" "325.6" "292.9" "224.9" "232.6" "290.9" "281.4" "280.2" "301.7" "284.8" "304.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "14.628" "13" "3" "4" "3" "323" "37.1" "5.92" "15.70" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "" "mRNA Splicing - Major Pathway" "1" "0" "0.900" "1.002" "0.973" "0.952" "0.877" "0.950" "1.028" "0.948" "0.932" "177.0" "159.2" "177.3" "172.2" "168.5" "155.2" "168.2" "181.9" "167.8" "164.9" "" "" "" "" "" "" "" "" "" "" "177.0" "134.7" "112.1" "125.6" "138.1" "120.5" "129.6" "156.4" "131.0" "148.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "14.627" "6" "3" "4" "3" "573" "62.6" "5.21" "12.89" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "1" "0" "1.001" "0.799" "1.000" "1.023" "0.857" "0.927" "0.970" "0.862" "0.939" "203.7" "203.9" "162.8" "203.7" "208.4" "174.6" "188.8" "197.7" "175.6" "191.3" "" "" "" "" "" "" "" "" "" "" "203.7" "172.5" "102.9" "148.6" "170.7" "135.6" "145.5" "169.9" "137.1" "172.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "14.620" "34" "3" "8" "3" "76" "8.5" "8.88" "20.53" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.037" "1.108" "1.131" "1.124" "1.141" "1.108" "1.144" "1.116" "1.146" "179.0" "185.6" "198.3" "202.5" "201.2" "204.2" "198.4" "204.7" "199.7" "205.2" "" "" "" "" "" "" "" "" "" "" "179.0" "157.0" "125.4" "147.6" "164.8" "158.6" "152.9" "176.0" "155.9" "184.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8377264718886898276" "False" "High" "IsMasterProtein" "Q9Y2K7" "Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3" "0.000" "False" "14.617" "3" "3" "3" "3" "1162" "132.7" "7.58" "10.09" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00646, Pf02008, Pf16866, Pf17811" "22992" "ENSG00000173120" "KDM2A" "D4QA03; E9PIL6; hsa:22992; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; Q9Y2K7" "" "HDMs demethylate histones" "1" "0" "0.989" "0.905" "1.093" "1.219" "0.976" "1.212" "1.053" "0.985" "1.009" "157.5" "155.7" "142.5" "172.2" "192.0" "153.7" "190.9" "165.9" "155.2" "158.9" "" "" "" "" "" "" "" "" "" "" "157.5" "131.7" "90.1" "125.6" "157.3" "119.4" "147.2" "142.6" "121.1" "142.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "14.595" "10" "3" "3" "3" "285" "33.3" "5.86" "9.41" "3" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "1.077" "1.189" "1.029" "1.107" "1.342" "1.363" "1.140" "1.109" "1.025" "184.5" "198.7" "219.3" "189.8" "204.2" "247.7" "251.5" "210.2" "204.6" "189.1" "" "" "" "" "" "" "" "" "" "" "184.5" "168.1" "138.6" "138.4" "167.3" "192.3" "193.9" "180.8" "159.7" "170.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177067630619702561" "False" "High" "IsMasterProtein" "Q969S9" "Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1" "0.000" "False" "14.594" "7" "5" "5" "5" "779" "86.5" "6.51" "17.28" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "84340" "ENSG00000164347" "GFM2" "A0AR28; hsa:84340; Q8N6D8; Q8WYI0; Q969S9; Q9H6Z1" "" "Mitochondrial translation termination" "1" "0" "0.995" "0.830" "1.007" "1.032" "0.901" "1.079" "1.102" "0.836" "1.018" "133.7" "133.0" "111.0" "134.7" "137.9" "120.4" "144.2" "147.3" "111.7" "136.1" "" "" "" "" "" "" "" "" "" "" "133.7" "112.5" "70.2" "98.2" "113.0" "93.5" "111.1" "126.6" "87.2" "122.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "14.576" "30" "4" "6" "4" "144" "16.6" "7.81" "19.31" "4" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.921" "1.022" "0.912" "0.827" "0.998" "0.970" "0.903" "1.054" "0.921" "612.3" "563.8" "625.8" "558.2" "506.5" "611.3" "594.0" "552.8" "645.6" "564.0" "" "" "" "" "" "" "" "" "" "" "612.3" "477.0" "395.7" "407.0" "415.0" "474.8" "457.9" "475.3" "503.9" "507.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "14.574" "13" "3" "5" "3" "211" "24.2" "5.74" "16.71" "3" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.959" "1.018" "0.942" "0.938" "0.975" "0.976" "0.963" "0.950" "0.980" "842.9" "808.4" "858.1" "794.4" "791.0" "822.1" "822.6" "811.7" "800.4" "826.0" "" "" "" "" "" "" "" "" "" "" "842.9" "684.0" "542.6" "579.2" "648.0" "638.4" "634.1" "697.9" "624.8" "742.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "14.574" "23" "4" "7" "4" "125" "14.5" "10.54" "20.01" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.115" "1.516" "0.925" "1.121" "1.477" "1.073" "1.205" "1.605" "1.160" "223.2" "248.9" "338.4" "206.3" "250.1" "329.5" "239.5" "268.9" "358.1" "258.9" "" "" "" "" "" "" "" "" "" "" "223.2" "210.5" "214.0" "150.4" "204.9" "255.9" "184.6" "231.2" "279.5" "232.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "14.522" "11" "5" "5" "5" "503" "53.5" "5.05" "12.63" "5" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "6" "0" "1.139" "1.005" "1.109" "1.166" "1.041" "1.174" "1.135" "0.877" "1.011" "103.1" "117.4" "103.6" "114.3" "120.2" "107.3" "121.0" "117.0" "90.4" "104.2" "" "" "" "" "" "" "" "" "" "" "103.1" "99.3" "65.5" "83.4" "98.5" "83.4" "93.3" "100.6" "70.5" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "14.515" "20" "3" "5" "3" "118" "13.1" "4.88" "13.50" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "Regulation of expression of SLITs and ROBOs; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Evasion by RSV of host interferon responses" "22" "0" "0.933" "0.954" "0.965" "0.959" "0.960" "1.014" "0.954" "0.943" "0.986" "352.0" "328.5" "335.9" "339.7" "337.8" "338.1" "356.8" "336.0" "331.8" "347.1" "" "" "" "" "" "" "" "" "" "" "352.0" "277.9" "212.4" "247.7" "276.7" "262.5" "275.0" "288.9" "259.0" "312.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "14.508" "7" "4" "4" "4" "664" "72.6" "7.39" "14.65" "4" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "9" "0" "1.027" "1.094" "1.098" "1.079" "1.257" "1.104" "1.053" "1.153" "1.032" "392.4" "402.8" "429.2" "430.9" "423.3" "493.3" "433.1" "413.1" "452.4" "405.0" "" "" "" "" "" "" "" "" "" "" "392.4" "340.7" "271.4" "314.2" "346.8" "383.1" "333.8" "355.2" "353.1" "364.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "14.496" "8" "3" "5" "3" "368" "41.5" "5.43" "15.89" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Fragile X syndrome" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "6" "0" "1.087" "1.050" "1.104" "1.071" "1.088" "1.100" "1.052" "0.978" "1.171" "304.6" "331.1" "319.8" "336.2" "326.3" "331.4" "335.0" "320.3" "297.9" "356.5" "" "" "" "" "" "" "" "" "" "" "304.6" "280.1" "202.2" "245.1" "267.3" "257.4" "258.2" "275.4" "232.6" "320.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "High" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.000" "False" "14.493" "11" "2" "6" "2" "215" "23.4" "10.93" "22.50" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.946" "1.236" "1.172" "1.171" "1.358" "1.210" "1.333" "1.475" "1.173" "343.6" "324.9" "424.5" "402.6" "402.4" "466.7" "415.7" "457.8" "506.8" "403.0" "" "" "" "" "" "" "" "" "" "" "343.6" "274.9" "268.4" "293.5" "329.7" "362.4" "320.4" "393.6" "395.6" "362.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.000" "False" "14.490" "4" "4" "4" "4" "1188" "133.9" "6.33" "14.45" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "1.134" "0.985" "1.017" "1.310" "1.053" "1.161" "0.849" "0.975" "1.194" "54.8" "62.2" "54.0" "55.8" "71.8" "57.7" "63.6" "46.5" "53.4" "65.5" "" "" "" "" "" "" "" "" "" "" "54.8" "52.6" "34.1" "40.7" "58.8" "44.8" "49.1" "40.0" "41.7" "58.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145524999594346517" "False" "High" "IsMasterProtein" "O60518" "Ran-binding protein 6 OS=Homo sapiens OX=9606 GN=RANBP6 PE=1 SV=2" "0.000" "False" "14.486" "4" "3" "10" "2" "1105" "124.6" "5.01" "21.67" "3" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf13513, Pf18808, Pf18829" "26953" "ENSG00000137040" "RANBP6" "hsa:26953; O60518; Q5T7X4; Q7Z3V2; Q96E78" "" "" "0" "0" "0.911" "0.986" "1.112" "1.021" "0.937" "0.978" "1.038" "0.999" "1.077" "215.2" "196.0" "212.3" "239.3" "219.8" "201.8" "210.5" "223.5" "215.0" "231.8" "" "" "" "" "" "" "" "" "" "" "215.2" "165.9" "134.2" "174.5" "180.1" "156.7" "162.2" "192.2" "167.8" "208.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "High" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.000" "False" "14.485" "6" "5" "5" "5" "782" "86.0" "6.47" "15.05" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.207" "0.855" "0.897" "1.093" "0.988" "1.063" "1.079" "0.722" "1.045" "43.8" "52.8" "37.4" "39.2" "47.8" "43.2" "46.5" "47.2" "31.6" "45.7" "" "" "" "" "" "" "" "" "" "" "43.8" "44.7" "23.7" "28.6" "39.2" "33.6" "35.9" "40.6" "24.6" "41.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "14.480" "11" "5" "5" "3" "393" "43.4" "6.62" "18.64" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "102" "1" "1.034" "1.056" "0.987" "0.971" "0.978" "0.961" "1.015" "0.999" "0.976" "382.5" "395.4" "404.0" "377.4" "371.3" "374.1" "367.5" "388.4" "382.3" "373.2" "" "" "" "" "" "" "" "" "" "" "382.5" "334.6" "255.5" "275.2" "304.2" "290.5" "283.3" "333.9" "298.4" "335.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "14.457" "13" "4" "6" "4" "288" "32.7" "10.58" "16.79" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.962" "1.533" "1.071" "1.224" "1.440" "1.181" "1.433" "1.614" "1.220" "349.5" "336.1" "535.9" "374.2" "427.6" "503.2" "412.6" "500.8" "564.1" "426.4" "" "" "" "" "" "" "" "" "" "" "349.5" "284.3" "338.9" "272.9" "350.4" "390.8" "318.1" "430.6" "440.3" "383.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "14.456" "4" "2" "4" "2" "677" "76.0" "6.57" "13.14" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "12" "0" "1.028" "1.001" "1.033" "1.096" "1.153" "0.956" "1.134" "0.880" "1.282" "63.7" "65.5" "63.7" "65.8" "69.8" "73.5" "60.9" "72.2" "56.0" "81.6" "" "" "" "" "" "" "" "" "" "" "63.7" "55.4" "40.3" "48.0" "57.2" "57.0" "46.9" "62.1" "43.7" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "High" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.000" "False" "14.453" "2" "5" "5" "5" "2564" "287.4" "6.14" "16.10" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "PKMTs methylate histone lysines" "8" "0" "1.143" "0.952" "1.131" "1.220" "1.036" "1.032" "1.245" "0.892" "0.990" "85.9" "98.1" "81.7" "97.1" "104.8" "89.0" "88.6" "106.9" "76.6" "85.0" "" "" "" "" "" "" "" "" "" "" "85.9" "83.0" "51.7" "70.8" "85.8" "69.1" "68.3" "91.9" "59.8" "76.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "14.449" "10" "2" "4" "2" "277" "31.0" "5.83" "17.17" "2" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Glycosphingolipid catabolism" "5" "0" "1.124" "1.023" "1.161" "1.260" "1.131" "1.356" "1.251" "0.974" "1.026" "153.7" "172.7" "157.1" "178.5" "193.5" "173.7" "208.4" "192.2" "149.6" "157.6" "" "" "" "" "" "" "" "" "" "" "153.7" "146.1" "99.4" "130.1" "158.6" "134.9" "160.6" "165.2" "116.8" "141.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "14.434" "35" "3" "6" "3" "110" "12.4" "6.73" "16.65" "3" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "2q13 copy number variation syndrome" "Mitochondrial protein import" "2" "0" "1.228" "1.064" "1.385" "1.343" "1.037" "1.232" "1.291" "1.087" "1.186" "120.7" "148.3" "128.5" "167.2" "162.1" "125.2" "148.7" "155.9" "131.3" "143.2" "" "" "" "" "" "" "" "" "" "" "120.7" "125.4" "81.2" "121.9" "132.8" "97.2" "114.6" "134.1" "102.5" "128.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "14.423" "3" "4" "4" "4" "1411" "151.1" "8.03" "13.55" "4" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "1.091" "0.915" "1.112" "1.289" "1.053" "1.103" "0.970" "0.983" "1.015" "118.0" "128.7" "108.0" "131.2" "152.1" "124.2" "130.1" "114.5" "116.0" "119.7" "" "" "" "" "" "" "" "" "" "" "118.0" "108.9" "68.3" "95.7" "124.6" "96.5" "100.3" "98.4" "90.6" "107.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "14.418" "19" "4" "6" "4" "219" "24.3" "6.21" "17.36" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396940342238216990" "False" "High" "IsMasterProtein" "Q9H6Y2" "WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2" "0.000" "False" "14.411" "11" "3" "3" "3" "383" "42.0" "4.92" "11.76" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf12894" "54853" "ENSG00000120314" "WDR55" "hsa:54853; Q9H6Y2; Q9NXK4" "" "" "0" "0" "1.334" "0.805" "1.105" "0.692" "1.026" "0.959" "1.078" "0.906" "0.926" "34.5" "46.0" "27.8" "38.1" "23.9" "35.4" "33.1" "37.2" "31.3" "31.9" "" "" "" "" "" "" "" "" "" "" "34.5" "38.9" "17.6" "27.8" "19.6" "27.5" "25.5" "32.0" "24.4" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "14.411" "8" "5" "5" "5" "593" "63.5" "6.83" "12.67" "5" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "IL-18 signaling pathway" "Neutrophil degranulation" "2" "0" "0.888" "0.907" "1.157" "0.756" "0.874" "1.024" "0.941" "0.726" "0.802" "51.5" "45.7" "46.7" "59.6" "38.9" "45.0" "52.7" "48.4" "37.4" "41.3" "" "" "" "" "" "" "" "" "" "" "51.5" "38.7" "29.5" "43.4" "31.9" "35.0" "40.6" "41.7" "29.2" "37.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "14.380" "15" "5" "8" "5" "327" "36.1" "5.73" "24.58" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "DNA Damage Recognition in GG-NER; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.083" "1.100" "0.986" "1.040" "1.099" "0.976" "1.048" "0.943" "1.014" "259.3" "280.8" "285.1" "255.8" "269.8" "284.9" "253.1" "271.9" "244.5" "263.0" "" "" "" "" "" "" "" "" "" "" "259.3" "237.5" "180.3" "186.5" "221.0" "221.3" "195.1" "233.8" "190.9" "236.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "14.361" "16" "4" "4" "4" "320" "34.5" "5.33" "12.91" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.847" "1.344" "1.225" "1.404" "0.882" "1.506" "1.534" "1.478" "1.618" "18.2" "33.5" "24.4" "22.2" "25.5" "16.0" "27.3" "27.8" "26.8" "29.4" "" "" "" "" "" "" "" "" "" "" "18.2" "28.4" "15.4" "16.2" "20.9" "12.4" "21.1" "23.9" "20.9" "26.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "14.357" "8" "5" "7" "5" "548" "63.4" "8.31" "17.09" "5" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "0.966" "1.468" "1.107" "1.369" "1.163" "1.084" "0.977" "1.151" "1.320" "59.4" "57.4" "87.2" "65.8" "81.3" "69.1" "64.4" "58.0" "68.4" "78.4" "" "" "" "" "" "" "" "" "" "" "59.4" "48.6" "55.1" "48.0" "66.6" "53.7" "49.6" "49.9" "53.4" "70.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5519015022968038253" "False" "High" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "0.000" "False" "14.354" "3" "4" "4" "4" "1494" "166.7" "6.79" "13.48" "4" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "0.998" "0.794" "0.911" "0.987" "0.995" "0.975" "0.983" "0.893" "0.938" "77.9" "77.8" "61.8" "70.9" "76.9" "77.5" "75.9" "76.6" "69.5" "73.0" "" "" "" "" "" "" "" "" "" "" "77.9" "65.8" "39.1" "51.7" "63.0" "60.2" "58.5" "65.8" "54.3" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5967874803311728941" "False" "High" "IsMasterProtein" "Q9UBP0" "Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1" "0.000" "False" "14.341" "6" "3" "3" "3" "616" "67.2" "9.64" "10.87" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862" "6683" "ENSG00000021574" "SPAST" "A7E2A7; hsa:6683; Q9UBP0; Q9UPR9" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "0" "1.045" "0.932" "1.085" "1.066" "1.062" "1.055" "1.118" "0.860" "1.026" "173.2" "181.1" "161.4" "187.9" "184.6" "184.0" "182.7" "193.6" "149.0" "177.7" "" "" "" "" "" "" "" "" "" "" "173.2" "153.2" "102.0" "137.0" "151.2" "142.9" "140.9" "166.4" "116.3" "159.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "14.324" "7" "4" "5" "4" "726" "79.4" "5.55" "14.64" "4" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "" "Platelet degranulation" "1" "0" "1.048" "1.054" "0.923" "1.023" "1.393" "0.953" "1.063" "2.073" "1.231" "49.5" "51.9" "52.2" "45.7" "50.6" "68.9" "47.1" "52.6" "102.5" "60.9" "" "" "" "" "" "" "" "" "" "" "49.5" "43.9" "33.0" "33.3" "41.5" "53.5" "36.3" "45.2" "80.0" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "14.307" "8" "3" "5" "3" "485" "53.3" "7.03" "16.50" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production" "4" "0" "0.958" "0.988" "0.994" "0.990" "1.024" "1.070" "1.043" "0.930" "1.033" "257.8" "247.0" "254.7" "256.2" "255.2" "264.1" "275.7" "268.9" "239.8" "266.4" "" "" "" "" "" "" "" "" "" "" "257.8" "209.0" "161.1" "186.8" "209.1" "205.1" "212.5" "231.2" "187.1" "239.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "14.302" "10" "4" "5" "4" "398" "44.4" "6.98" "14.88" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.956" "0.934" "1.008" "0.946" "1.006" "0.885" "0.988" "0.913" "0.932" "360.4" "344.3" "336.4" "363.1" "341.0" "362.5" "318.9" "356.1" "329.2" "335.8" "" "" "" "" "" "" "" "" "" "" "360.4" "291.3" "212.7" "264.7" "279.4" "281.5" "245.8" "306.1" "256.9" "301.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.000" "False" "14.296" "6" "4" "5" "4" "633" "69.5" "6.28" "17.87" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "8" "0" "1.009" "0.820" "1.007" "1.097" "0.864" "1.001" "1.010" "0.839" "0.978" "468.2" "472.5" "384.0" "471.7" "513.6" "404.5" "468.8" "473.1" "392.8" "457.9" "" "" "" "" "" "" "" "" "" "" "468.2" "399.7" "242.8" "343.9" "420.8" "314.1" "361.4" "406.7" "306.6" "411.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "14.286" "28" "3" "4" "3" "142" "16.3" "4.79" "9.94" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Pyrimidine metabolism" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "42" "0" "0.768" "0.817" "0.763" "0.784" "0.842" "1.171" "1.244" "1.048" "1.009" "14.7" "11.3" "12.0" "11.2" "11.5" "12.4" "17.2" "18.2" "15.4" "14.8" "" "" "" "" "" "" "" "" "" "" "14.7" "9.5" "7.6" "8.2" "9.4" "9.6" "13.2" "15.7" "12.0" "13.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "14.286" "11" "5" "5" "3" "382" "43.0" "7.28" "16.11" "5" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "7" "0" "0.895" "0.938" "0.982" "0.907" "0.987" "0.908" "0.973" "0.988" "0.855" "349.0" "312.3" "327.3" "342.8" "316.7" "344.4" "317.0" "339.7" "344.9" "298.3" "" "" "" "" "" "" "" "" "" "" "349.0" "264.2" "207.0" "250.0" "259.4" "267.4" "244.3" "292.1" "269.2" "268.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "14.273" "7" "4" "6" "4" "541" "61.2" "6.49" "18.83" "4" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "0.919" "0.858" "0.861" "1.017" "0.844" "0.940" "0.996" "0.872" "0.961" "235.5" "216.4" "202.1" "202.8" "239.5" "198.7" "221.4" "234.6" "205.3" "226.3" "" "" "" "" "" "" "" "" "" "" "235.5" "183.1" "127.8" "147.9" "196.2" "154.3" "170.7" "201.7" "160.3" "203.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "14.264" "19" "4" "5" "4" "167" "19.1" "8.37" "15.14" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "" "RAB geranylgeranylation" "1" "0" "1.017" "1.070" "0.944" "0.959" "1.064" "0.959" "1.007" "1.073" "1.017" "497.3" "505.8" "532.4" "469.7" "477.1" "529.2" "477.2" "500.7" "533.8" "505.9" "" "" "" "" "" "" "" "" "" "" "497.3" "427.9" "336.6" "342.5" "390.9" "411.0" "367.8" "430.5" "416.7" "454.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5520460410914984228" "False" "High" "IsMasterProtein" "Q9NSG2" "FIGNL1-interacting regulator of recombination and mitosis OS=Homo sapiens OX=9606 GN=FIRRM PE=1 SV=1" "0.000" "False" "14.264" "6" "4" "5" "4" "853" "96.5" "6.00" "16.35" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14868" "55732" "ENSG00000000460" "FIRRM" "A6NFP1; B3KU42; hsa:55732; Q3KNQ1; Q9H8L5; Q9NSG2; Q9NVJ0" "" "" "0" "0" "1.041" "0.766" "1.139" "1.092" "0.698" "0.903" "1.113" "0.598" "0.862" "92.2" "96.0" "70.6" "104.9" "100.7" "64.4" "83.2" "102.6" "55.2" "79.5" "" "" "" "" "" "" "" "" "" "" "92.2" "81.2" "44.6" "76.5" "82.5" "50.0" "64.2" "88.2" "43.1" "71.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "934468542703033965" "False" "High" "IsMasterProtein" "Q15477" "Superkiller complex protein 2 OS=Homo sapiens OX=9606 GN=SKIC2 PE=1 SV=3" "0.000" "False" "14.262" "3" "4" "4" "4" "1246" "137.7" "6.06" "13.86" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf17911, Pf21408" "6499" "ENSG00000204351; ENSG00000206353; ENSG00000223493; ENSG00000225737; ENSG00000228896; ENSG00000232616" "SKIC2" "hsa:6499; O15005; Q12902; Q15476; Q15477; Q5ST66" "" "Association of TriC/CCT with target proteins during biosynthesis; mRNA decay by 3' to 5' exoribonuclease" "2" "0" "0.978" "0.893" "1.018" "1.033" "0.890" "1.052" "1.048" "0.836" "1.043" "162.9" "159.3" "145.5" "165.9" "168.2" "144.9" "171.3" "170.7" "136.1" "169.9" "" "" "" "" "" "" "" "" "" "" "162.9" "134.8" "92.0" "120.9" "137.8" "112.5" "132.0" "146.8" "106.3" "152.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6959093533306709871" "False" "High" "IsMasterProtein" "P0DPD7" "EEF1A lysine methyltransferase 4 OS=Homo sapiens OX=9606 GN=EEF1AKMT4 PE=1 SV=1" "0.000" "False" "14.254" "12" "3" "3" "3" "255" "28.3" "6.05" "11.68" "3" "other metabolic processes" "" "other molecular function" "Pf08241" "110599564" "ENSG00000284753" "EEF1AKMT4" "A5PLK8; hsa:110599564; O60344; P0DPD7; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8" "" "" "0" "0" "1.060" "0.859" "1.037" "1.027" "0.851" "1.037" "1.096" "0.784" "0.995" "248.2" "263.1" "213.3" "257.3" "255.0" "211.2" "257.3" "271.9" "194.6" "247.1" "" "" "" "" "" "" "" "" "" "" "248.2" "222.6" "134.9" "187.6" "208.9" "164.1" "198.3" "233.8" "151.9" "222.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "High" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.000" "False" "14.250" "10" "5" "5" "5" "465" "52.3" "7.03" "13.38" "5" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "Tryptophan catabolism" "4" "0" "0.955" "1.014" "0.959" "1.006" "1.035" "1.091" "1.002" "0.908" "1.049" "358.8" "342.8" "363.7" "344.0" "360.8" "371.3" "391.6" "359.5" "325.8" "376.2" "" "" "" "" "" "" "" "" "" "" "358.8" "290.0" "229.9" "250.8" "295.6" "288.4" "301.8" "309.1" "254.3" "338.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "14.249" "13" "4" "4" "4" "343" "38.8" "5.69" "11.48" "4" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "" "mRNA Splicing - Major Pathway" "1" "0" "0.882" "1.022" "1.010" "0.924" "0.960" "0.999" "1.006" "0.893" "0.990" "237.3" "209.3" "242.4" "239.6" "219.3" "227.7" "237.1" "238.7" "212.0" "234.9" "" "" "" "" "" "" "" "" "" "" "237.3" "177.0" "153.3" "174.7" "179.7" "176.8" "182.8" "205.2" "165.5" "211.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "14.235" "5" "2" "2" "1" "621" "66.2" "5.06" "9.14" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "0.951" "0.865" "1.400" "1.149" "0.825" "1.107" "1.128" "0.807" "1.337" "19.4" "18.5" "16.8" "27.2" "22.3" "16.0" "21.5" "21.9" "15.7" "26.0" "" "" "" "" "" "" "" "" "" "" "19.4" "15.6" "10.6" "19.8" "18.3" "12.5" "16.6" "18.8" "12.2" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245887775356859101" "False" "High" "IsMasterProtein" "Q8N0Z6" "Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2" "0.000" "False" "14.220" "12" "5" "7" "5" "440" "48.9" "6.48" "15.17" "5" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16669" "91875" "ENSG00000136319; ENSG00000291781" "TTC5" "A8MQ18; hsa:91875; Q8N0Z6; Q96HF9" "" "Regulation of TP53 Activity through Methylation" "1" "0" "0.935" "0.767" "1.031" "1.032" "0.813" "0.978" "0.965" "0.831" "0.934" "200.7" "187.6" "154.0" "206.9" "207.2" "163.2" "196.3" "193.6" "166.7" "187.5" "" "" "" "" "" "" "" "" "" "" "200.7" "158.7" "97.4" "150.9" "169.7" "126.8" "151.3" "166.4" "130.1" "168.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7286073100971465543" "False" "High" "IsMasterProtein" "O95466" "Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3" "0.000" "False" "14.210" "4" "5" "6" "5" "1100" "121.8" "5.72" "18.33" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "752" "ENSG00000184922" "FMNL1" "D2DGW2; hsa:752; O95466; Q6DKG5; Q6IBP3; Q86UH1; Q8N671; Q8TDH1; Q96H10" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate Formins" "3" "0" "0.922" "0.837" "0.924" "0.931" "0.903" "0.969" "0.982" "0.864" "0.873" "330.3" "304.6" "276.4" "305.2" "307.4" "298.1" "320.1" "324.5" "285.5" "288.4" "" "" "" "" "" "" "" "" "" "" "330.3" "257.7" "174.8" "222.5" "251.9" "231.5" "246.8" "279.0" "222.8" "259.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-929965012723082693" "False" "High" "IsMasterProtein" "Q969E4" "Transcription elongation factor A protein-like 3 OS=Homo sapiens OX=9606 GN=TCEAL3 PE=1 SV=1" "0.000" "False" "14.181" "20" "3" "4" "3" "200" "22.5" "4.92" "14.62" "3" "" "nucleus" "" "Pf04538" "85012" "ENSG00000196507" "TCEAL3" "D3DXA4; hsa:85012; Q969E4" "" "" "0" "0" "0.931" "0.999" "1.001" "1.018" "1.138" "1.135" "1.086" "0.972" "1.031" "131.6" "122.5" "131.5" "131.8" "134.0" "149.7" "149.4" "142.9" "127.9" "135.6" "" "" "" "" "" "" "" "" "" "" "131.6" "103.7" "83.2" "96.1" "109.8" "116.3" "115.2" "122.9" "99.8" "121.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "High" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.000" "False" "14.172" "6" "2" "3" "2" "396" "44.2" "5.19" "11.72" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "" "Processing of Capped Intron-Containing Pre-mRNA" "1" "0" "1.114" "1.727" "1.117" "1.093" "1.625" "1.081" "1.088" "1.551" "1.226" "132.9" "148.1" "229.6" "148.5" "145.2" "216.0" "143.6" "144.7" "206.1" "163.0" "" "" "" "" "" "" "" "" "" "" "132.9" "125.3" "145.2" "108.3" "119.0" "167.8" "110.7" "124.4" "160.9" "146.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.000" "False" "14.168" "9" "2" "3" "2" "274" "30.7" "6.02" "12.70" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "15" "0" "1.039" "1.035" "0.938" "1.017" "0.993" "1.029" "1.092" "1.045" "1.012" "226.9" "235.7" "234.9" "212.7" "230.8" "225.3" "233.6" "247.8" "237.1" "229.6" "" "" "" "" "" "" "" "" "" "" "226.9" "199.4" "148.5" "155.1" "189.1" "174.9" "180.0" "213.0" "185.1" "206.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "14.145" "3" "3" "3" "3" "1055" "122.1" "5.34" "10.00" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "" "Ub-specific processing proteases" "1" "0" "0.844" "0.808" "1.216" "0.987" "0.756" "0.989" "1.031" "1.014" "0.964" "44.5" "37.6" "36.0" "54.1" "44.0" "33.6" "44.0" "45.9" "45.2" "42.9" "" "" "" "" "" "" "" "" "" "" "44.5" "31.8" "22.8" "39.5" "36.0" "26.1" "33.9" "39.5" "35.2" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.000" "False" "14.141" "6" "4" "4" "4" "590" "66.2" "5.10" "13.24" "4" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "0.931" "0.863" "1.102" "1.118" "0.905" "1.085" "1.032" "0.974" "1.038" "112.1" "104.4" "96.7" "123.5" "125.4" "101.5" "121.6" "115.6" "109.2" "116.3" "" "" "" "" "" "" "" "" "" "" "112.1" "88.3" "61.2" "90.1" "102.7" "78.8" "93.7" "99.4" "85.2" "104.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "14.140" "9" "3" "3" "3" "316" "35.4" "6.30" "11.01" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "Leukocyte-intrinsic Hippo pathway functions" "" "1" "0" "1.020" "0.783" "1.124" "1.082" "0.743" "1.179" "1.070" "0.719" "0.972" "476.6" "486.2" "373.0" "535.7" "515.8" "354.0" "562.1" "509.8" "342.5" "463.4" "" "" "" "" "" "" "" "" "" "" "476.6" "411.3" "235.9" "390.6" "422.6" "274.9" "433.3" "438.3" "267.3" "416.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "14.135" "8" "4" "4" "4" "627" "70.7" "6.74" "13.07" "4" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "" "Neddylation" "1" "0" "1.111" "1.582" "1.282" "1.172" "1.208" "1.145" "1.105" "1.253" "1.112" "16.0" "17.8" "25.4" "20.6" "18.8" "19.4" "18.4" "17.7" "20.1" "17.8" "" "" "" "" "" "" "" "" "" "" "16.0" "15.1" "16.0" "15.0" "15.4" "15.0" "14.2" "15.2" "15.7" "16.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8182350314247288702" "False" "High" "IsMasterProtein" "Q9NVQ4" "Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1" "0.000" "False" "14.132" "22" "4" "6" "4" "179" "20.2" "5.83" "18.97" "4" "signal transduction;other biological processes" "other cell component" "" "Pf06905" "55179" "ENSG00000158234" "FAIM" "hsa:55179; Q6IAN2; Q9NVQ4" "Neurogenesis regulation in the olfactory epithelium" "" "1" "0" "0.857" "0.766" "0.893" "0.860" "0.816" "0.902" "0.933" "0.792" "0.877" "495.8" "424.7" "379.6" "442.9" "426.5" "404.4" "447.0" "462.4" "392.9" "434.8" "" "" "" "" "" "" "" "" "" "" "495.8" "359.3" "240.0" "323.0" "349.4" "314.1" "344.6" "397.5" "306.7" "390.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102844417532121967" "False" "High" "IsMasterProtein" "Q15560" "Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1" "0.000" "False" "14.123" "11" "3" "3" "1" "299" "33.6" "9.13" "10.37" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6919" "ENSG00000171703" "TCEA2" "B3KNM1; Q15560; Q8TD37; Q8TD38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7065461624018501642" "False" "High" "IsMasterProtein" "Q96JB5" "CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2" "0.000" "False" "14.097" "8" "4" "5" "4" "506" "56.9" "4.75" "11.23" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05600" "80279" "ENSG00000108465" "CDK5RAP3" "B7Z6N4; D3DTU1; D3DTU2; F5H3I5; hsa:80279; Q53FA2; Q96JB5; Q9H3F8; Q9H8G0; Q9HBR9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-27127465578060112" "False" "High" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "0.000" "False" "14.096" "6" "4" "4" "4" "736" "83.1" "6.18" "10.28" "4" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "" "Synthesis of bile acids and bile salts" "1" "0" "0.978" "0.993" "1.073" "1.070" "1.077" "1.023" "1.012" "0.910" "0.909" "125.8" "123.0" "124.8" "134.9" "134.6" "135.5" "128.6" "127.2" "114.4" "114.4" "" "" "" "" "" "" "" "" "" "" "125.8" "104.0" "78.9" "98.4" "110.2" "105.2" "99.2" "109.4" "89.3" "102.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4647062156116842215" "False" "High" "IsMasterProtein" "P20749" "B-cell lymphoma 3 protein OS=Homo sapiens OX=9606 GN=BCL3 PE=1 SV=2" "0.000" "False" "14.084" "11" "4" "4" "4" "454" "47.6" "8.41" "10.53" "4" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00023" "602" "ENSG00000069399" "BCL3" "P20749" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced AP-1 survival signaling" "" "2" "0" "1.104" "0.926" "1.114" "1.012" "0.920" "1.047" "0.909" "1.006" "0.961" "163.1" "180.0" "151.1" "181.7" "165.1" "150.1" "170.8" "148.3" "164.2" "156.8" "" "" "" "" "" "" "" "" "" "" "163.1" "152.3" "95.5" "132.5" "135.3" "116.6" "131.6" "127.5" "128.1" "140.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8609206004865475892" "False" "High" "IsMasterProtein" "Q96BD8" "Spindle and kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=SKA1 PE=1 SV=1" "0.000" "False" "14.078" "9" "2" "4" "2" "255" "29.5" "7.12" "11.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf07160" "220134" "ENSG00000154839; ENSG00000262634" "SKA1" "B2R9Y6; B4E0P4; hsa:220134; Q96BD8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.124" "0.550" "1.042" "1.100" "0.786" "1.247" "1.105" "0.808" "0.847" "47.4" "53.3" "26.1" "49.4" "52.1" "37.2" "59.1" "52.4" "38.3" "40.2" "" "" "" "" "" "" "" "" "" "" "47.4" "45.1" "16.5" "36.0" "42.7" "28.9" "45.5" "45.0" "29.9" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "14.056" "11" "2" "5" "2" "195" "21.7" "7.74" "15.71" "2" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "0.962" "0.907" "0.865" "0.933" "0.929" "0.877" "0.989" "0.942" "0.948" "284.3" "273.4" "257.9" "246.0" "265.4" "264.0" "249.3" "281.1" "267.8" "269.5" "" "" "" "" "" "" "" "" "" "" "284.3" "231.3" "163.1" "179.4" "217.4" "205.0" "192.2" "241.7" "209.1" "242.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "14.051" "12" "3" "4" "3" "215" "23.4" "8.65" "13.45" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.181" "1.056" "1.009" "1.101" "1.127" "1.066" "1.109" "1.058" "1.116" "234.1" "276.4" "247.2" "236.2" "257.7" "263.8" "249.5" "259.7" "247.7" "261.3" "" "" "" "" "" "" "" "" "" "" "234.1" "233.9" "156.3" "172.2" "211.2" "204.9" "192.3" "223.3" "193.4" "234.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "14.045" "11" "3" "4" "3" "327" "37.0" "5.57" "13.07" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "Ciliary landscape" "" "1" "0" "1.051" "0.831" "1.073" "1.062" "0.948" "1.158" "1.041" "0.887" "1.068" "128.6" "135.2" "106.9" "137.9" "136.6" "121.9" "148.9" "133.9" "114.0" "137.3" "" "" "" "" "" "" "" "" "" "" "128.6" "114.4" "67.6" "100.5" "111.9" "94.6" "114.8" "115.1" "89.0" "123.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "14.045" "16" "4" "5" "3" "238" "27.4" "11.82" "15.14" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "1" "1.214" "1.193" "1.109" "1.093" "1.146" "1.277" "1.181" "1.240" "1.081" "171.7" "208.5" "204.8" "190.5" "187.7" "196.8" "219.4" "202.8" "212.9" "185.7" "" "" "" "" "" "" "" "" "" "" "171.7" "176.4" "129.5" "138.9" "153.8" "152.8" "169.1" "174.4" "166.2" "166.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "14.041" "6" "5" "7" "5" "738" "84.7" "6.05" "14.35" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Collagen biosynthesis and modifying enzymes" "3" "0" "1.053" "0.979" "1.076" "1.096" "0.940" "1.045" "0.995" "1.028" "1.078" "334.5" "352.2" "327.4" "360.0" "366.7" "314.4" "349.5" "332.9" "344.0" "360.6" "" "" "" "" "" "" "" "" "" "" "334.5" "298.0" "207.0" "262.5" "300.4" "244.2" "269.4" "286.3" "268.5" "324.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "13.988" "8" "4" "4" "4" "491" "55.9" "6.90" "13.49" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "0.999" "0.763" "1.056" "1.203" "0.810" "1.226" "1.072" "0.880" "1.044" "84.5" "84.4" "64.5" "89.3" "101.7" "68.5" "103.6" "90.6" "74.4" "88.3" "" "" "" "" "" "" "" "" "" "" "84.5" "71.4" "40.8" "65.1" "83.3" "53.2" "79.9" "77.9" "58.1" "79.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "13.985" "5" "2" "3" "2" "426" "46.6" "8.05" "11.64" "2" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Valproic acid pathway" "Branched-chain amino acid catabolism" "2" "0" "1.014" "1.014" "1.027" "0.992" "1.009" "0.987" "1.034" "1.033" "1.002" "180.3" "182.7" "182.8" "185.0" "178.8" "181.9" "177.8" "186.4" "186.2" "180.6" "" "" "" "" "" "" "" "" "" "" "180.3" "154.6" "115.6" "134.9" "146.5" "141.3" "137.1" "160.2" "145.4" "162.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "13.984" "6" "3" "4" "3" "545" "59.4" "6.29" "13.36" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "0.966" "0.866" "1.016" "0.875" "0.801" "0.929" "1.081" "0.807" "0.934" "181.5" "175.3" "157.2" "184.3" "158.8" "145.4" "168.7" "196.3" "146.5" "169.6" "" "" "" "" "" "" "" "" "" "" "181.5" "148.3" "99.4" "134.4" "130.1" "112.9" "130.0" "168.7" "114.3" "152.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "13.982" "13" "3" "3" "3" "385" "42.0" "9.69" "9.00" "3" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "13.963" "6" "4" "4" "4" "558" "66.4" "8.84" "12.22" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.228" "1.084" "1.070" "1.162" "1.387" "1.272" "1.162" "1.158" "1.185" "97.6" "119.9" "105.8" "104.4" "113.4" "135.3" "124.1" "113.4" "113.0" "115.6" "" "" "" "" "" "" "" "" "" "" "97.6" "101.4" "66.9" "76.1" "92.9" "105.1" "95.7" "97.5" "88.2" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.000" "False" "13.960" "9" "3" "3" "3" "446" "49.4" "4.92" "12.05" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.024" "0.983" "0.814" "1.051" "0.801" "1.032" "1.024" "0.687" "0.940" "43.9" "44.9" "43.1" "35.7" "46.1" "35.1" "45.3" "44.9" "30.1" "41.2" "" "" "" "" "" "" "" "" "" "" "43.9" "38.0" "27.3" "26.0" "37.8" "27.3" "34.9" "38.6" "23.5" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "13.957" "18" "4" "4" "4" "235" "27.4" "7.69" "12.03" "4" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.863" "1.004" "1.219" "1.060" "1.086" "1.119" "1.129" "1.043" "0.888" "55.1" "47.6" "55.3" "67.1" "58.4" "59.8" "61.6" "62.2" "57.4" "48.9" "" "" "" "" "" "" "" "" "" "" "55.1" "40.2" "35.0" "48.9" "47.8" "46.5" "47.5" "53.5" "44.8" "44.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "13.940" "23" "4" "7" "4" "179" "21.5" "5.68" "19.47" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.000" "0.872" "0.947" "1.043" "0.995" "0.970" "1.056" "0.894" "0.974" "490.5" "490.6" "428.0" "464.4" "511.8" "488.0" "475.7" "517.9" "438.5" "478.0" "" "" "" "" "" "" "" "" "" "" "490.5" "415.0" "270.6" "338.6" "419.3" "379.0" "366.7" "445.3" "342.3" "429.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-189490632571161728" "False" "High" "IsMasterProtein" "Q9P2E3" "NFX1-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNFX1 PE=1 SV=2" "0.000" "False" "13.932" "3" "4" "5" "4" "1918" "220.1" "7.30" "13.01" "4" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13086, Pf13087, Pf20173" "57169" "ENSG00000124201" "ZNFX1" "hsa:57169; Q9BQM7; Q9BQM8; Q9H8C1; Q9H9S2; Q9NUM1; Q9NWW1; Q9P2E3" "" "" "0" "0" "0.991" "0.911" "1.062" "1.141" "0.948" "1.121" "1.136" "0.873" "0.992" "286.1" "283.4" "260.5" "303.7" "326.6" "271.1" "320.8" "324.9" "249.9" "283.9" "" "" "" "" "" "" "" "" "" "" "286.1" "239.8" "164.7" "221.5" "267.6" "210.5" "247.3" "279.3" "195.0" "255.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "13.926" "17" "2" "2" "2" "228" "26.7" "4.97" "7.74" "2" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "Ciliary landscape" "" "1" "0" "1.117" "1.270" "1.480" "1.282" "1.292" "1.448" "1.052" "1.203" "1.418" "31.4" "35.1" "39.9" "46.5" "40.3" "40.6" "45.5" "33.0" "37.8" "44.5" "" "" "" "" "" "" "" "" "" "" "31.4" "29.7" "25.2" "33.9" "33.0" "31.5" "35.1" "28.4" "29.5" "40.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "13.924" "15" "5" "9" "5" "248" "27.1" "4.51" "30.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "17" "0" "1.156" "1.047" "1.055" "1.125" "1.151" "1.194" "1.092" "1.180" "1.169" "702.7" "812.2" "735.8" "741.2" "790.4" "809.0" "838.9" "767.1" "829.0" "821.8" "" "" "" "" "" "" "" "" "" "" "702.7" "687.2" "465.2" "540.5" "647.6" "628.3" "646.7" "659.6" "647.1" "738.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "13.915" "16" "3" "4" "3" "270" "30.0" "7.69" "18.34" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes" "3" "0" "1.039" "0.932" "0.978" "1.043" "1.022" "0.961" "0.947" "0.878" "1.088" "174.4" "181.2" "162.6" "170.5" "181.9" "178.2" "167.7" "165.2" "153.1" "189.7" "" "" "" "" "" "" "" "" "" "" "174.4" "153.3" "102.8" "124.3" "149.0" "138.4" "129.2" "142.0" "119.5" "170.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.000" "False" "13.904" "6" "4" "4" "4" "669" "78.4" "5.40" "13.65" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "0.890" "0.722" "1.001" "1.212" "0.882" "0.852" "0.913" "0.624" "0.977" "34.4" "30.6" "24.8" "34.5" "41.7" "30.3" "29.3" "31.4" "21.5" "33.6" "" "" "" "" "" "" "" "" "" "" "34.4" "25.9" "15.7" "25.1" "34.2" "23.6" "22.6" "27.0" "16.8" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "13.895" "5" "5" "5" "5" "1093" "122.8" "4.92" "14.95" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.062" "1.004" "1.155" "1.048" "1.102" "1.201" "1.030" "1.020" "1.073" "265.9" "282.4" "266.9" "307.2" "278.6" "292.9" "319.4" "273.9" "271.1" "285.3" "" "" "" "" "" "" "" "" "" "" "265.9" "238.9" "168.7" "224.0" "228.3" "227.5" "246.2" "235.5" "211.6" "256.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "13.883" "45" "3" "5" "2" "89" "10.4" "7.40" "16.81" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "28" "1" "0.931" "0.916" "1.041" "0.952" "1.054" "0.842" "0.969" "1.103" "0.977" "127.0" "118.3" "116.3" "132.3" "120.9" "133.9" "107.0" "123.1" "140.1" "124.1" "" "" "" "" "" "" "" "" "" "" "127.0" "100.1" "73.6" "96.4" "99.1" "104.0" "82.5" "105.9" "109.3" "111.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.000" "False" "13.883" "6" "5" "6" "5" "823" "93.5" "6.93" "17.70" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "" "Ub-specific processing proteases" "1" "0" "0.913" "0.949" "1.002" "0.962" "0.918" "0.991" "0.997" "0.959" "0.889" "461.6" "421.3" "437.9" "462.3" "444.0" "423.8" "457.4" "460.5" "442.6" "410.4" "" "" "" "" "" "" "" "" "" "" "461.6" "356.4" "276.9" "337.1" "363.7" "329.2" "352.6" "395.9" "345.5" "369.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815959030617886930" "False" "High" "IsMasterProtein" "O75167" "Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2" "0.000" "False" "13.880" "3" "2" "4" "2" "634" "69.7" "8.16" "9.52" "2" "cell organization and biogenesis" "plasma membrane;other membranes" "enzyme regulator activity;cytoskeletal activity" "Pf02755" "9749" "ENSG00000112419" "PHACTR2" "A6NKP5; A7MCZ5; A8MZC0; B2RWP7; B4DN76; B4DPB5; B4DTH7; hsa:9749; O75167; Q5TFA0; Q68DM2" "" "Platelet degranulation" "1" "0" "1.253" "1.270" "0.952" "1.027" "1.023" "0.917" "0.960" "1.103" "0.998" "65.3" "81.9" "83.0" "62.2" "67.1" "66.9" "59.9" "62.7" "72.0" "65.2" "" "" "" "" "" "" "" "" "" "" "65.3" "69.3" "52.5" "45.3" "55.0" "51.9" "46.2" "53.9" "56.2" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "13.870" "6" "4" "5" "4" "579" "65.5" "9.60" "14.76" "4" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "1.168" "1.969" "1.118" "1.144" "2.269" "0.978" "1.060" "2.225" "1.382" "93.1" "108.8" "183.3" "104.1" "106.5" "211.2" "91.0" "98.6" "207.1" "128.6" "" "" "" "" "" "" "" "" "" "" "93.1" "92.0" "115.9" "75.9" "87.3" "164.0" "70.2" "84.8" "161.7" "115.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "13.858" "12" "3" "5" "3" "306" "33.9" "8.57" "12.99" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "" "Glucuronidation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "13.852" "17" "4" "7" "4" "173" "18.8" "6.68" "18.67" "4" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "" "XBP1(S) activates chaperone genes" "1" "0" "0.976" "1.002" "0.953" "0.954" "0.929" "1.014" "1.000" "0.973" "0.958" "688.8" "672.0" "690.0" "656.3" "657.4" "639.9" "698.6" "688.6" "670.3" "659.7" "" "" "" "" "" "" "" "" "" "" "688.8" "568.5" "436.3" "478.5" "538.6" "496.9" "538.5" "592.0" "523.2" "593.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "13.839" "27" "3" "3" "3" "158" "16.2" "10.15" "14.25" "3" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "13.832" "13" "4" "6" "4" "322" "36.1" "5.12" "13.94" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "" "2" "0" "1.019" "0.847" "0.918" "0.949" "0.759" "0.951" "0.902" "0.829" "0.936" "213.6" "217.6" "180.9" "196.0" "202.6" "162.1" "203.1" "192.7" "177.0" "199.9" "" "" "" "" "" "" "" "" "" "" "213.6" "184.1" "114.4" "142.9" "166.0" "125.9" "156.6" "165.7" "138.1" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "13.831" "11" "4" "4" "4" "394" "44.2" "9.09" "13.59" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "1.060" "0.967" "0.922" "1.073" "1.168" "0.894" "0.932" "0.921" "1.014" "119.7" "126.9" "115.8" "110.3" "128.4" "139.9" "107.0" "111.6" "110.3" "121.4" "" "" "" "" "" "" "" "" "" "" "119.7" "107.4" "73.2" "80.5" "105.2" "108.6" "82.5" "96.0" "86.1" "109.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "13.819" "6" "3" "3" "3" "673" "75.5" "6.73" "10.14" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "1.219" "1.075" "1.150" "1.235" "0.968" "1.292" "1.199" "1.084" "1.304" "77.1" "94.0" "82.9" "88.7" "95.3" "74.7" "99.7" "92.5" "83.6" "100.6" "" "" "" "" "" "" "" "" "" "" "77.1" "79.5" "52.4" "64.7" "78.1" "58.0" "76.8" "79.5" "65.2" "90.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "13.818" "19" "3" "5" "3" "205" "22.8" "9.89" "18.96" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.117" "1.149" "1.085" "1.168" "1.092" "1.106" "1.102" "1.133" "1.137" "172.7" "192.8" "198.5" "187.4" "201.7" "188.6" "191.0" "190.2" "195.6" "196.4" "" "" "" "" "" "" "" "" "" "" "172.7" "163.1" "125.5" "136.7" "165.2" "146.5" "147.2" "163.5" "152.7" "176.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "13.814" "5" "3" "3" "3" "736" "78.9" "6.02" "10.61" "3" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "Asymmetric localization of PCP proteins; Degradation of DVL; RHO GTPases Activate Formins; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "29" "0" "1.049" "0.730" "1.036" "0.968" "0.697" "0.912" "0.978" "0.848" "0.930" "194.7" "204.3" "142.2" "201.7" "188.5" "135.7" "177.5" "190.4" "165.2" "181.1" "" "" "" "" "" "" "" "" "" "" "194.7" "172.8" "89.9" "147.1" "154.5" "105.4" "136.8" "163.7" "129.0" "162.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7145479494712382587" "False" "High" "IsMasterProtein" "P80217" "Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5" "0.000" "False" "13.807" "21" "5" "6" "5" "286" "31.5" "6.09" "13.02" "5" "stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "3430" "ENSG00000068079" "IFI35" "C9JGX1; hsa:3430; P80217; Q92984; Q99537; Q9BV98" "Immune response to tuberculosis" "Interferon alpha/beta signaling" "2" "0" "0.905" "1.074" "1.096" "0.996" "0.926" "1.006" "1.038" "1.030" "1.045" "147.8" "133.7" "158.7" "161.9" "147.2" "136.8" "148.6" "153.4" "152.2" "154.4" "" "" "" "" "" "" "" "" "" "" "147.8" "113.1" "100.4" "118.0" "120.6" "106.2" "114.5" "131.9" "118.8" "138.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.000" "False" "13.801" "9" "4" "4" "4" "520" "57.6" "7.01" "12.58" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.940" "0.860" "0.930" "1.209" "0.990" "1.247" "1.207" "1.076" "1.141" "75.5" "70.9" "64.9" "70.2" "91.3" "74.7" "94.1" "91.1" "81.2" "86.2" "" "" "" "" "" "" "" "" "" "" "75.5" "60.0" "41.1" "51.2" "74.8" "58.0" "72.6" "78.3" "63.4" "77.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1676018771169478995" "False" "High" "IsMasterProtein" "O60293" "Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3" "0.000" "False" "13.798" "2" "3" "3" "3" "1989" "226.2" "8.13" "11.56" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10650" "196441" "ENSG00000133858" "ZFC3H1" "hsa:196441; O60293; Q6GMU1; Q6P2S9; Q6ZV36; Q96BE7" "" "" "0" "0" "1.044" "0.981" "1.028" "1.075" "1.172" "0.930" "1.072" "0.876" "1.013" "72.9" "76.1" "71.6" "74.9" "78.4" "85.5" "67.8" "78.2" "63.9" "73.9" "" "" "" "" "" "" "" "" "" "" "72.9" "64.4" "45.2" "54.6" "64.2" "66.4" "52.3" "67.2" "49.9" "66.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.000" "False" "13.789" "5" "4" "5" "4" "711" "82.2" "7.61" "15.18" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "0.988" "0.908" "0.919" "1.004" "0.877" "0.980" "1.022" "0.862" "0.955" "416.0" "410.9" "377.6" "382.5" "417.5" "364.9" "407.5" "425.0" "358.5" "397.1" "" "" "" "" "" "" "" "" "" "" "416.0" "347.6" "238.8" "278.9" "342.1" "283.3" "314.1" "365.4" "279.9" "357.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "13.787" "30" "2" "2" "2" "106" "11.8" "8.09" "11.05" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "One-carbon metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.007" "1.124" "1.017" "0.939" "1.045" "1.246" "0.894" "0.908" "1.277" "30.2" "30.4" "33.9" "30.7" "28.3" "31.5" "37.6" "27.0" "27.4" "38.5" "" "" "" "" "" "" "" "" "" "" "30.2" "25.7" "21.4" "22.4" "23.2" "24.5" "29.0" "23.2" "21.4" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "13.785" "16" "2" "4" "2" "142" "16.8" "5.85" "11.32" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.525" "0.922" "1.413" "1.044" "1.223" "0.874" "0.820" "1.163" "0.960" "23.0" "35.1" "21.2" "32.5" "24.0" "28.1" "20.1" "18.9" "26.7" "22.1" "" "" "" "" "" "" "" "" "" "" "23.0" "29.7" "13.4" "23.7" "19.7" "21.9" "15.5" "16.2" "20.9" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665594491149638353" "False" "High" "IsMasterProtein" "P12931" "Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3" "0.000" "False" "13.783" "6" "4" "4" "3" "536" "59.8" "7.42" "14.36" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "6714" "ENSG00000197122; ENSG00000291971" "SRC" "E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8" "Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; MET in type 1 papillary renal cell carcinoma; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; G alpha (i) signalling events; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; Signaling by BRAF and RAF1 fusions; Regulation of RUNX3 expression and activity; RHOU GTPase cycle; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K" "90" "0" "1.058" "1.096" "1.095" "1.070" "1.091" "1.033" "1.012" "1.150" "1.036" "371.1" "392.5" "406.5" "406.5" "397.1" "405.0" "383.3" "375.5" "426.7" "384.3" "" "" "" "" "" "" "" "" "" "" "371.1" "332.1" "257.1" "296.4" "325.4" "314.5" "295.4" "322.8" "333.1" "345.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "13.768" "8" "4" "4" "4" "613" "66.9" "8.95" "11.42" "4" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "" "3" "0" "1.134" "1.361" "1.030" "1.164" "1.378" "1.051" "0.912" "1.481" "1.367" "99.1" "112.3" "134.8" "102.0" "115.3" "136.5" "104.1" "90.3" "146.7" "135.4" "" "" "" "" "" "" "" "" "" "" "99.1" "95.0" "85.3" "74.4" "94.4" "106.0" "80.2" "77.7" "114.5" "121.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2996634066211424368" "False" "High" "IsMasterProtein" "Q92994" "Transcription factor IIIB 90 kDa subunit OS=Homo sapiens OX=9606 GN=BRF1 PE=1 SV=1" "0.000" "False" "13.747" "8" "4" "4" "4" "677" "73.8" "5.43" "11.95" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf07741, Pf08271" "2972" "ENSG00000185024" "BRF1" "B3KU36; B4DIG5; B7Z2N3; F5H5Z7; F8WA46; hsa:2972; Q13223; Q3SYD9; Q5PR24; Q6IQ02; Q92994; Q96KX3; Q9HCW6; Q9HCW7; Q9HCW8" "TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "4" "0" "1.035" "0.809" "1.010" "0.930" "0.867" "1.010" "0.950" "0.897" "1.028" "150.4" "155.6" "121.6" "151.9" "139.8" "130.4" "151.9" "142.8" "134.8" "154.6" "" "" "" "" "" "" "" "" "" "" "150.4" "131.6" "76.9" "110.8" "114.5" "101.3" "117.1" "122.8" "105.2" "139.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.000" "False" "13.725" "3" "2" "3" "2" "779" "88.8" "6.27" "11.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.993" "0.957" "1.020" "0.979" "0.972" "0.952" "0.921" "0.867" "0.991" "181.5" "180.3" "173.8" "185.3" "177.8" "176.5" "172.8" "167.3" "157.5" "179.9" "" "" "" "" "" "" "" "" "" "" "181.5" "152.5" "109.9" "135.1" "145.7" "137.0" "133.2" "143.8" "122.9" "161.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "13.720" "14" "5" "5" "5" "299" "33.3" "7.52" "13.84" "5" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "" "Urea cycle" "1" "0" "0.890" "0.780" "0.925" "0.996" "0.771" "0.962" "0.972" "0.817" "0.968" "201.5" "179.2" "157.1" "186.4" "200.6" "155.3" "193.8" "195.8" "164.7" "195.0" "" "" "" "" "" "" "" "" "" "" "201.5" "151.6" "99.3" "135.9" "164.4" "120.6" "149.4" "168.3" "128.5" "175.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3186791909088934819" "False" "High" "IsMasterProtein" "Q96JB2" "Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3" "0.000" "False" "13.714" "5" "4" "4" "4" "828" "94.0" "5.57" "14.51" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "" "Pf04136, Pf20671" "83548" "ENSG00000136152" "COG3" "B2RAW5; hsa:83548; Q5VT70; Q8IXX4; Q96JB2; Q9BZ92" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "1.105" "0.985" "1.158" "1.051" "1.021" "1.102" "1.094" "1.169" "1.136" "117.2" "129.5" "115.4" "135.7" "123.2" "119.7" "129.1" "128.2" "137.0" "133.1" "" "" "" "" "" "" "" "" "" "" "117.2" "109.5" "73.0" "98.9" "100.9" "93.0" "99.5" "110.2" "106.9" "119.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "13.710" "12" "5" "6" "5" "363" "40.7" "5.95" "15.24" "5" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "3" "0" "1.097" "0.995" "1.068" "1.131" "1.195" "1.142" "1.110" "1.074" "1.064" "230.1" "252.5" "228.9" "245.8" "260.1" "275.0" "262.7" "255.5" "247.1" "244.9" "" "" "" "" "" "" "" "" "" "" "230.1" "213.7" "144.7" "179.3" "213.1" "213.5" "202.5" "219.7" "192.9" "220.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "13.706" "10" "4" "5" "4" "520" "57.9" "5.72" "14.92" "4" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "1.040" "0.719" "0.991" "1.078" "1.029" "0.955" "0.918" "0.886" "0.958" "63.9" "66.5" "46.0" "63.3" "68.9" "65.8" "61.1" "58.7" "56.6" "61.2" "" "" "" "" "" "" "" "" "" "" "63.9" "56.2" "29.1" "46.2" "56.5" "51.1" "47.1" "50.5" "44.2" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "13.689" "3" "5" "5" "5" "1668" "196.5" "9.42" "12.78" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "1.191" "1.575" "1.042" "1.093" "1.527" "1.015" "1.035" "1.663" "1.242" "181.3" "216.0" "285.7" "188.9" "198.2" "276.9" "184.1" "187.6" "301.5" "225.2" "" "" "" "" "" "" "" "" "" "" "181.3" "182.8" "180.6" "137.7" "162.4" "215.0" "141.9" "161.3" "235.3" "202.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "13.686" "9" "2" "2" "2" "376" "42.5" "5.57" "9.21" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "" "mRNA Splicing - Major Pathway" "1" "0" "1.182" "1.069" "1.027" "1.094" "1.175" "1.004" "1.020" "1.025" "1.155" "63.8" "75.5" "68.2" "65.5" "69.9" "75.0" "64.1" "65.1" "65.4" "73.7" "" "" "" "" "" "" "" "" "" "" "63.8" "63.8" "43.1" "47.8" "57.2" "58.2" "49.4" "56.0" "51.0" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "13.678" "5" "2" "3" "2" "540" "59.7" "7.66" "10.10" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "13.675" "3" "4" "4" "4" "1510" "167.5" "6.02" "11.36" "4" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "13.671" "16" "4" "4" "4" "267" "30.2" "10.08" "12.35" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.029" "0.925" "0.922" "1.097" "0.995" "1.010" "1.007" "0.947" "1.035" "238.3" "245.3" "220.4" "219.7" "261.4" "237.2" "240.8" "240.0" "225.7" "246.8" "" "" "" "" "" "" "" "" "" "" "238.3" "207.5" "139.3" "160.2" "214.1" "184.2" "185.6" "206.3" "176.2" "221.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.000" "False" "13.659" "9" "5" "5" "5" "624" "69.6" "6.44" "10.82" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Potential therapeutics for SARS; Nuclear events mediated by NFE2L2" "16" "0" "1.105" "0.742" "0.983" "1.078" "0.986" "1.009" "1.069" "0.930" "0.918" "32.8" "36.2" "24.3" "32.2" "35.3" "32.3" "33.1" "35.0" "30.5" "30.1" "" "" "" "" "" "" "" "" "" "" "32.8" "30.6" "15.4" "23.5" "28.9" "25.1" "25.5" "30.1" "23.8" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5153257351632709387" "False" "High" "IsMasterProtein" "P26374" "Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens OX=9606 GN=CHML PE=1 SV=2" "0.000" "False" "13.657" "6" "5" "5" "4" "656" "74.0" "4.93" "16.14" "5" "protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1122" "ENSG00000203668" "CHML" "B2RAB9; hsa:1122; P26374; Q17RE0; Q9H1Y4" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "2" "1" "0.944" "0.991" "1.048" "1.041" "0.914" "1.021" "0.905" "0.975" "0.941" "167.5" "158.1" "166.0" "175.6" "174.4" "153.1" "171.0" "151.6" "163.3" "157.7" "" "" "" "" "" "" "" "" "" "" "167.5" "133.8" "105.0" "128.0" "142.9" "118.9" "131.8" "130.4" "127.5" "141.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8999845406277562527" "False" "High" "IsMasterProtein" "Q9H089" "Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2" "0.000" "False" "13.614" "5" "3" "3" "3" "658" "75.2" "6.38" "10.16" "3" "transport" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01926" "55341" "ENSG00000041802" "LSG1" "A0JLT4; A0PJK3; A6NI18; hsa:55341; Q7L9H8; Q9H089; Q9NUK8" "" "" "0" "0" "1.073" "1.014" "1.244" "1.262" "0.999" "1.192" "1.140" "1.113" "0.997" "73.1" "78.5" "74.2" "91.0" "92.3" "73.1" "87.2" "83.4" "81.4" "72.9" "" "" "" "" "" "" "" "" "" "" "73.1" "66.4" "46.9" "66.3" "75.6" "56.8" "67.2" "71.7" "63.5" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139328666383470964" "False" "High" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.000" "False" "13.608" "2" "4" "5" "4" "1706" "194.0" "7.21" "13.27" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "miRNA degrading enzymes" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "4" "0" "1.070" "0.923" "1.069" "1.239" "1.033" "0.999" "1.054" "1.085" "0.925" "74.8" "80.0" "69.0" "79.9" "92.6" "77.2" "74.7" "78.8" "81.2" "69.2" "" "" "" "" "" "" "" "" "" "" "74.8" "67.7" "43.6" "58.3" "75.9" "60.0" "57.6" "67.8" "63.3" "62.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "13.600" "6" "2" "3" "2" "493" "57.8" "5.63" "11.73" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.031" "1.182" "1.174" "1.147" "1.218" "1.061" "0.977" "1.113" "1.089" "109.7" "113.2" "129.7" "128.9" "125.8" "133.7" "116.5" "107.2" "122.1" "119.5" "" "" "" "" "" "" "" "" "" "" "109.7" "95.8" "82.0" "94.0" "103.1" "103.8" "89.8" "92.2" "95.3" "107.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "13.591" "2" "2" "3" "2" "1053" "112.9" "6.25" "9.50" "2" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "0.957" "0.863" "1.438" "0.982" "0.948" "0.953" "1.018" "0.926" "1.027" "35.6" "34.1" "30.8" "51.2" "35.0" "33.8" "33.9" "36.2" "33.0" "36.6" "" "" "" "" "" "" "" "" "" "" "35.6" "28.8" "19.4" "37.3" "28.7" "26.2" "26.2" "31.2" "25.7" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.000" "False" "13.578" "7" "4" "7" "2" "743" "76.4" "6.81" "15.52" "4" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "Integrated cancer pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "6" "2" "0.980" "0.965" "1.122" "1.010" "1.002" "1.044" "0.965" "0.947" "0.982" "244.9" "239.9" "236.4" "274.8" "247.3" "245.4" "255.7" "236.4" "231.9" "240.5" "" "" "" "" "" "" "" "" "" "" "244.9" "203.0" "149.5" "200.4" "202.6" "190.6" "197.1" "203.2" "181.0" "216.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1224682826513998034" "False" "High" "IsMasterProtein" "O00255" "Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=5" "0.000" "False" "13.575" "6" "3" "3" "3" "610" "67.5" "6.55" "9.56" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05053" "4221" "ENSG00000133895" "MEN1" "A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; O00255; O00632; Q9BUF0; Q9BUK2" "10q11.21q11.23 copy number variation syndrome" "RHO GTPases activate IQGAPs; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "8" "0" "1.019" "1.009" "0.696" "0.780" "0.708" "1.226" "1.173" "0.620" "0.986" "16.6" "16.9" "16.7" "11.5" "12.9" "11.7" "20.3" "19.4" "10.3" "16.3" "" "" "" "" "" "" "" "" "" "" "16.6" "14.3" "10.6" "8.4" "10.6" "9.1" "15.6" "16.7" "8.0" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2033172296880987561" "False" "High" "IsMasterProtein" "P12259" "Coagulation factor V OS=Homo sapiens OX=9606 GN=F5 PE=1 SV=4" "0.000" "False" "13.570" "2" "3" "3" "3" "2224" "251.5" "6.05" "12.27" "3" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00754, Pf07732" "2153" "ENSG00000198734" "F5" "A8K6E8; hsa:2153; P12259; Q14285; Q2EHR5; Q5R346; Q5R347; Q6UPU6; Q8WWQ6" "Blood clotting cascade; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; COPII-mediated vesicle transport; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation" "9" "0" "0.932" "0.964" "0.948" "1.074" "0.855" "1.136" "1.120" "1.140" "1.145" "47.7" "44.4" "45.9" "45.2" "51.2" "40.8" "54.1" "53.4" "54.3" "54.6" "" "" "" "" "" "" "" "" "" "" "47.7" "37.6" "29.1" "32.9" "41.9" "31.7" "41.7" "45.9" "42.4" "49.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.000" "False" "13.562" "10" "5" "5" "5" "464" "54.3" "8.27" "15.91" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.013" "0.619" "0.827" "0.803" "0.662" "0.881" "0.948" "0.697" "0.849" "256.1" "259.5" "158.5" "211.7" "205.6" "169.5" "225.5" "242.8" "178.4" "217.3" "" "" "" "" "" "" "" "" "" "" "256.1" "219.5" "100.2" "154.3" "168.4" "131.6" "173.9" "208.8" "139.3" "195.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "13.561" "8" "2" "4" "2" "324" "37.0" "6.77" "15.34" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.033" "0.964" "1.037" "1.100" "1.032" "1.083" "1.003" "1.033" "1.030" "438.6" "453.0" "422.8" "454.8" "482.4" "452.5" "475.1" "440.0" "453.3" "451.8" "" "" "" "" "" "" "" "" "" "" "438.6" "383.3" "267.4" "331.6" "395.2" "351.4" "366.2" "378.4" "353.8" "406.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "13.540" "4" "3" "4" "3" "1270" "136.3" "4.70" "8.38" "3" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "" "PKMTs methylate histone lysines" "1" "0" "1.048" "0.944" "1.094" "0.878" "0.961" "1.002" "1.072" "0.990" "1.020" "124.0" "130.0" "117.0" "135.7" "108.8" "119.2" "124.2" "132.9" "122.8" "126.5" "" "" "" "" "" "" "" "" "" "" "124.0" "110.0" "74.0" "98.9" "89.2" "92.6" "95.7" "114.3" "95.8" "113.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "13.536" "4" "7" "7" "7" "1369" "155.1" "8.09" "18.53" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.095" "1.196" "1.131" "1.100" "1.035" "1.082" "1.103" "0.927" "1.202" "45.2" "49.5" "54.1" "51.2" "49.8" "46.8" "48.9" "49.9" "41.9" "54.3" "" "" "" "" "" "" "" "" "" "" "45.2" "41.9" "34.2" "37.3" "40.8" "36.3" "37.7" "42.9" "32.7" "48.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944115724239200420" "False" "High" "IsMasterProtein" "O43310" "CBP80/20-dependent translation initiation factor OS=Homo sapiens OX=9606 GN=CTIF PE=1 SV=1" "0.000" "False" "13.535" "6" "3" "4" "3" "598" "67.5" "6.54" "13.24" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854" "9811" "ENSG00000134030; ENSG00000282825" "CTIF" "B3KTR8; hsa:9811; O43310; Q8IVD5" "" "" "0" "0" "1.034" "1.025" "1.140" "1.130" "1.096" "1.177" "1.069" "1.095" "1.114" "227.9" "235.6" "233.5" "259.7" "257.6" "249.8" "268.2" "243.5" "249.6" "253.9" "" "" "" "" "" "" "" "" "" "" "227.9" "199.3" "147.7" "189.4" "211.1" "194.0" "206.8" "209.4" "194.9" "228.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8254999691274013684" "False" "High" "IsMasterProtein" "Q9HAV0" "Guanine nucleotide-binding protein subunit beta-4 OS=Homo sapiens OX=9606 GN=GNB4 PE=1 SV=3" "0.000" "False" "13.527" "8" "3" "4" "3" "340" "37.5" "6.00" "12.23" "3" "signal transduction" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "59345" "ENSG00000114450" "GNB4" "B3KMH5; D3DNR8; hsa:59345; Q9HAV0" "Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "ADORA2B mediated anti-inflammatory cytokines production; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "34" "0" "0.958" "0.902" "1.020" "0.997" "0.860" "0.983" "1.039" "0.856" "0.920" "237.2" "227.2" "214.1" "242.1" "236.4" "204.1" "233.1" "246.4" "203.1" "218.3" "" "" "" "" "" "" "" "" "" "" "237.2" "192.2" "135.4" "176.5" "193.7" "158.5" "179.7" "211.9" "158.5" "196.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "13.513" "5" "3" "4" "3" "565" "63.1" "5.72" "14.13" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Cell cycle" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.921" "0.771" "1.040" "1.026" "0.882" "1.019" "1.016" "0.818" "0.882" "108.1" "99.6" "83.4" "112.5" "111.0" "95.4" "110.2" "109.8" "88.5" "95.4" "" "" "" "" "" "" "" "" "" "" "108.1" "84.3" "52.7" "82.0" "90.9" "74.1" "84.9" "94.4" "69.1" "85.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "13.494" "10" "4" "4" "4" "346" "39.2" "5.71" "12.31" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.078" "1.221" "1.200" "0.948" "0.954" "0.857" "0.902" "1.013" "1.034" "62.0" "66.8" "75.7" "74.4" "58.8" "59.1" "53.1" "55.9" "62.8" "64.1" "" "" "" "" "" "" "" "" "" "" "62.0" "56.5" "47.9" "54.2" "48.2" "45.9" "40.9" "48.1" "49.0" "57.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627020223265262766" "False" "High" "IsMasterProtein" "Q8N0W3" "L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2" "0.000" "False" "13.493" "5" "4" "4" "4" "1084" "117.5" "6.25" "11.86" "4" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf07959, Pf08544" "197258" "ENSG00000157353" "FCSK" "hsa:197258; Q5PSM3; Q5XKL6; Q6ZRA0; Q8N0W3; Q96MT9" "" "GDP-fucose biosynthesis" "1" "0" "1.082" "1.133" "1.167" "0.970" "1.159" "1.013" "1.061" "1.056" "0.995" "69.8" "75.5" "79.1" "81.4" "67.7" "80.9" "70.7" "74.0" "73.7" "69.4" "" "" "" "" "" "" "" "" "" "" "69.8" "63.9" "50.0" "59.3" "55.4" "62.8" "54.5" "63.6" "57.5" "62.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "13.487" "7" "5" "5" "4" "688" "77.5" "4.97" "15.24" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "mRNA processing" "Maturation of nucleoprotein" "2" "0" "1.137" "0.922" "1.186" "1.180" "1.026" "1.108" "1.195" "1.026" "1.098" "212.0" "241.0" "195.4" "251.5" "250.2" "217.5" "235.0" "253.3" "217.4" "232.7" "" "" "" "" "" "" "" "" "" "" "212.0" "203.9" "123.6" "183.3" "205.0" "168.9" "181.1" "217.8" "169.7" "209.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5013600273074776242" "False" "High" "IsMasterProtein" "Q9NZ09" "Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1" "0.000" "False" "13.483" "4" "1" "2" "1" "502" "55.0" "5.11" "6.83" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21267" "51271" "ENSG00000165006" "UBAP1" "B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; hsa:51271; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; Q9NZ09" "" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "5" "0" "0.958" "0.855" "1.095" "1.283" "1.051" "1.074" "0.993" "0.956" "0.838" "44.7" "42.9" "38.3" "49.0" "57.4" "47.0" "48.1" "44.4" "42.8" "37.5" "" "" "" "" "" "" "" "" "" "" "44.7" "36.3" "24.2" "35.7" "47.0" "36.5" "37.0" "38.2" "33.4" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "13.479" "26" "3" "6" "3" "119" "13.4" "9.94" "20.23" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.025" "1.262" "0.957" "1.078" "1.036" "0.870" "0.876" "1.053" "1.182" "377.9" "387.3" "476.9" "361.7" "407.2" "391.6" "328.9" "331.2" "397.9" "446.5" "" "" "" "" "" "" "" "" "" "" "377.9" "327.6" "301.5" "263.7" "333.7" "304.1" "253.6" "284.8" "310.6" "401.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "13.478" "14" "3" "3" "3" "376" "40.1" "5.27" "10.67" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "Protein hydroxylation" "1" "0" "1.104" "1.063" "1.092" "1.105" "1.085" "1.072" "1.086" "0.983" "1.086" "157.6" "174.0" "167.5" "172.1" "174.2" "171.1" "169.0" "171.1" "155.0" "171.2" "" "" "" "" "" "" "" "" "" "" "157.6" "147.2" "105.9" "125.5" "142.7" "132.8" "130.2" "147.2" "121.0" "153.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "13.462" "11" "3" "5" "3" "246" "29.1" "9.72" "12.79" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "Mitochondrial protein degradation; Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "9" "0" "0.798" "0.777" "0.763" "0.746" "0.682" "0.759" "0.700" "0.767" "0.736" "641.2" "511.6" "498.0" "489.2" "478.2" "437.4" "486.4" "448.9" "492.1" "471.8" "" "" "" "" "" "" "" "" "" "" "641.2" "432.8" "314.9" "356.7" "391.8" "339.7" "374.9" "386.0" "384.1" "424.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "13.452" "12" "2" "3" "2" "185" "20.5" "7.80" "9.09" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "MAPK signaling pathway; Fragile X syndrome" "ERKs are inactivated" "3" "0" "1.067" "0.924" "1.335" "0.959" "1.101" "1.067" "0.935" "1.117" "1.137" "35.8" "38.1" "33.1" "47.8" "34.3" "39.4" "38.1" "33.4" "39.9" "40.7" "" "" "" "" "" "" "" "" "" "" "35.8" "32.3" "20.9" "34.8" "28.1" "30.6" "29.4" "28.8" "31.2" "36.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "13.444" "7" "4" "4" "4" "608" "68.4" "7.65" "13.47" "4" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "" "Nonhomologous End-Joining (NHEJ)" "1" "0" "1.145" "1.047" "1.026" "1.162" "1.011" "1.088" "1.063" "1.180" "1.067" "193.5" "221.6" "202.7" "198.7" "224.8" "195.7" "210.6" "205.7" "228.4" "206.5" "" "" "" "" "" "" "" "" "" "" "193.5" "187.5" "128.2" "144.9" "184.2" "152.0" "162.3" "176.8" "178.3" "185.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "13.413" "6" "3" "4" "3" "452" "50.2" "6.47" "12.48" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.628" "0.521" "0.592" "0.573" "0.628" "0.574" "0.553" "0.546" "0.564" "341.7" "214.6" "177.9" "202.3" "196.0" "214.5" "196.2" "189.1" "186.5" "192.8" "" "" "" "" "" "" "" "" "" "" "341.7" "181.6" "112.5" "147.5" "160.6" "166.6" "151.2" "162.5" "145.5" "173.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "13.413" "2" "5" "5" "2" "1849" "208.6" "5.85" "13.91" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "13.408" "10" "4" "5" "4" "419" "46.3" "6.95" "18.52" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Amino acid metabolism" "Tyrosine catabolism" "2" "0" "1.021" "0.950" "1.033" "1.088" "1.063" "0.968" "0.978" "1.089" "1.067" "492.3" "502.7" "467.5" "508.5" "535.6" "523.2" "476.4" "481.5" "536.1" "525.1" "" "" "" "" "" "" "" "" "" "" "492.3" "425.3" "295.6" "370.8" "438.8" "406.3" "367.2" "414.0" "418.4" "472.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "13.404" "31" "3" "7" "3" "59" "6.9" "10.45" "20.39" "3" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "1.241" "1.164" "1.269" "1.171" "1.247" "1.172" "1.145" "1.408" "1.311" "36.5" "45.3" "42.5" "46.4" "42.8" "45.6" "42.8" "41.8" "51.4" "47.9" "" "" "" "" "" "" "" "" "" "" "36.5" "38.4" "26.9" "33.8" "35.1" "35.4" "33.0" "36.0" "40.2" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "13.391" "12" "4" "4" "4" "319" "36.6" "6.30" "11.05" "4" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "13.386" "4" "3" "3" "3" "661" "72.1" "6.16" "11.07" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "Ciliary landscape" "" "1" "0" "1.048" "0.902" "1.165" "1.118" "0.938" "1.088" "1.162" "0.950" "1.059" "180.9" "189.5" "163.1" "210.8" "202.2" "169.7" "196.9" "210.2" "171.8" "191.5" "" "" "" "" "" "" "" "" "" "" "180.9" "160.3" "103.1" "153.7" "165.6" "131.8" "151.7" "180.8" "134.1" "172.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2898221823971910502" "False" "High" "IsMasterProtein" "Q96H79" "Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2" "0.000" "False" "13.380" "8" "3" "4" "3" "300" "32.9" "8.13" "13.21" "3" "" "cytosol" "" "Pf18606" "92092" "ENSG00000146858" "ZC3HAV1L" "hsa:92092; Q8WUD9; Q96H79" "" "" "0" "0" "0.912" "0.985" "1.089" "0.901" "0.792" "0.811" "0.879" "0.885" "0.965" "256.1" "233.5" "252.3" "278.8" "230.8" "202.9" "207.8" "225.2" "226.7" "247.0" "" "" "" "" "" "" "" "" "" "" "256.1" "197.5" "159.5" "203.3" "189.1" "157.6" "160.2" "193.6" "177.0" "222.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "13.377" "5" "4" "5" "4" "677" "76.2" "7.03" "16.11" "4" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "DNA repair pathways, full network" "Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex" "5" "0" "1.132" "1.059" "1.135" "0.988" "1.238" "1.207" "0.918" "0.980" "1.030" "126.4" "143.2" "133.9" "143.5" "124.9" "156.6" "152.6" "116.1" "123.9" "130.2" "" "" "" "" "" "" "" "" "" "" "126.4" "121.1" "84.7" "104.6" "102.3" "121.6" "117.6" "99.8" "96.7" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "13.376" "16" "3" "4" "3" "247" "28.2" "9.36" "14.27" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Proximal tubule transport" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "0.873" "1.003" "0.818" "0.814" "0.836" "0.829" "0.896" "0.712" "0.958" "97.1" "84.8" "97.4" "79.4" "79.0" "81.2" "80.5" "87.0" "69.1" "93.0" "" "" "" "" "" "" "" "" "" "" "97.1" "71.7" "61.6" "57.9" "64.7" "63.0" "62.0" "74.8" "53.9" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670278986062403757" "False" "High" "IsMasterProtein" "P17050" "Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2" "0.000" "False" "13.374" "8" "3" "3" "3" "411" "46.5" "5.19" "11.15" "3" "other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf16499, Pf17450" "4668" "ENSG00000198951" "NAGA" "hsa:4668; P17050" "" "" "0" "0" "1.208" "1.024" "1.134" "1.194" "1.259" "1.185" "1.075" "1.193" "1.077" "156.3" "188.8" "160.0" "177.2" "186.5" "196.7" "185.2" "168.0" "186.5" "168.4" "" "" "" "" "" "" "" "" "" "" "156.3" "159.7" "101.2" "129.2" "152.8" "152.7" "142.8" "144.5" "145.6" "151.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "13.350" "10" "2" "5" "2" "242" "28.1" "9.99" "15.28" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.970" "0.926" "1.045" "1.041" "0.887" "0.969" "0.971" "0.830" "0.944" "155.3" "150.7" "143.9" "162.3" "161.6" "137.8" "150.5" "150.8" "128.9" "146.7" "" "" "" "" "" "" "" "" "" "" "155.3" "127.5" "91.0" "118.4" "132.4" "107.0" "116.0" "129.7" "100.6" "131.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "13.345" "10" "4" "4" "4" "380" "42.4" "5.77" "14.22" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "Mitochondrial complex III assembly" "" "1" "0" "0.984" "0.864" "0.957" "1.003" "0.902" "0.906" "1.086" "0.842" "1.060" "307.9" "303.0" "266.0" "294.7" "308.7" "277.8" "279.1" "334.2" "259.3" "326.5" "" "" "" "" "" "" "" "" "" "" "307.9" "256.4" "168.2" "214.9" "252.9" "215.7" "215.1" "287.3" "202.4" "293.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "13.316" "4" "2" "3" "2" "480" "54.4" "6.61" "11.39" "2" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Ciliary landscape" "Neutrophil degranulation; MHC class II antigen presentation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "6" "0" "0.965" "1.003" "0.840" "0.950" "1.077" "1.015" "0.956" "0.969" "1.053" "143.2" "138.2" "143.5" "120.3" "136.0" "154.1" "145.2" "136.9" "138.8" "150.7" "" "" "" "" "" "" "" "" "" "" "143.2" "116.9" "90.7" "87.7" "111.5" "119.7" "112.0" "117.7" "108.3" "135.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "13.312" "3" "4" "5" "4" "1336" "145.8" "9.17" "14.68" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs" "5" "0" "1.160" "1.366" "1.186" "1.238" "1.441" "1.282" "1.117" "1.459" "1.093" "199.1" "230.9" "272.1" "236.2" "246.6" "287.0" "255.3" "222.5" "290.5" "217.7" "" "" "" "" "" "" "" "" "" "" "199.1" "195.4" "172.0" "172.2" "202.0" "222.9" "196.8" "191.3" "226.7" "195.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "13.308" "7" "5" "6" "5" "607" "68.2" "6.64" "15.63" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "13.306" "5" "5" "6" "5" "862" "99.2" "5.01" "13.67" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "GDNF signaling" "TBC/RABGAPs" "2" "0" "0.984" "0.927" "0.971" "0.929" "1.002" "0.926" "1.047" "0.923" "0.957" "169.0" "166.3" "156.6" "164.1" "157.1" "169.3" "156.5" "176.9" "156.0" "161.8" "" "" "" "" "" "" "" "" "" "" "169.0" "140.7" "99.0" "119.7" "128.7" "131.5" "120.6" "152.1" "121.8" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "13.305" "5" "1" "2" "1" "299" "33.3" "5.97" "9.48" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "3" "0" "0.825" "1.059" "0.949" "0.809" "0.966" "0.725" "0.943" "1.030" "0.981" "27.2" "22.5" "28.8" "25.9" "22.0" "26.3" "19.8" "25.7" "28.1" "26.7" "" "" "" "" "" "" "" "" "" "" "27.2" "19.0" "18.2" "18.8" "18.0" "20.4" "15.2" "22.1" "21.9" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5515893546974733261" "False" "High" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=1 SV=2" "0.000" "False" "13.268" "16" "2" "3" "2" "123" "14.2" "11.53" "10.80" "2" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "0.999" "0.933" "1.080" "1.028" "1.005" "0.952" "1.131" "1.095" "0.979" "240.1" "239.9" "224.0" "259.3" "246.7" "241.2" "228.5" "271.6" "262.9" "235.1" "" "" "" "" "" "" "" "" "" "" "240.1" "203.0" "141.7" "189.0" "202.1" "187.3" "176.2" "233.5" "205.2" "211.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1283281267783462391" "False" "High" "IsMasterProtein" "Q7L4P6" "BEN domain-containing protein 5 OS=Homo sapiens OX=9606 GN=BEND5 PE=1 SV=1" "0.000" "False" "13.265" "11" "5" "5" "5" "421" "48.2" "6.20" "8.92" "5" "other biological processes" "ER/Golgi" "nucleic acid binding activity" "Pf10523" "79656" "ENSG00000162373" "BEND5" "D3DQ27; hsa:79656; Q7L4P6; Q96A62; Q9HAI3" "" "" "0" "0" "1.138" "0.931" "1.040" "1.194" "0.909" "1.235" "1.163" "0.814" "1.007" "100.0" "113.7" "93.1" "104.0" "119.3" "90.9" "123.5" "116.3" "81.4" "100.7" "" "" "" "" "" "" "" "" "" "" "100.0" "96.2" "58.9" "75.8" "97.8" "70.6" "95.2" "100.0" "63.5" "90.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "13.255" "4" "4" "4" "4" "960" "111.6" "7.87" "13.26" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Orexin receptor pathway" "Mitochondrial protein degradation; Regulation of Apoptosis" "3" "0" "1.036" "1.021" "1.020" "0.947" "1.121" "0.981" "1.009" "1.095" "0.969" "210.2" "217.7" "214.6" "214.3" "199.0" "235.5" "206.2" "212.0" "230.2" "203.6" "" "" "" "" "" "" "" "" "" "" "210.2" "184.1" "135.7" "156.3" "163.1" "182.9" "159.0" "182.3" "179.7" "183.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "13.251" "18" "3" "5" "2" "164" "19.3" "11.65" "12.69" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.111" "1.218" "0.983" "1.120" "1.088" "1.132" "1.077" "1.111" "1.230" "185.1" "205.6" "225.5" "181.9" "207.2" "201.4" "209.4" "199.3" "205.6" "227.7" "" "" "" "" "" "" "" "" "" "" "185.1" "173.9" "142.6" "132.6" "169.8" "156.4" "161.4" "171.4" "160.4" "204.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936218477733222076" "False" "High" "IsMasterProtein" "Q8N6T7" "NAD-dependent protein deacylase sirtuin-6 OS=Homo sapiens OX=9606 GN=SIRT6 PE=1 SV=2" "0.000" "False" "13.249" "6" "2" "4" "2" "355" "39.1" "9.19" "11.93" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "51548" "ENSG00000077463" "SIRT6" "B2RCD0; hsa:51548; O75291; Q6IAF5; Q6PK99; Q8N6T7; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1" "SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 10q11.21q11.23 copy number variation syndrome" "Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends" "9" "0" "1.008" "0.941" "1.036" "1.002" "0.898" "0.900" "0.987" "1.071" "1.060" "68.1" "68.6" "64.1" "70.5" "68.3" "61.2" "61.3" "67.2" "72.9" "72.2" "" "" "" "" "" "" "" "" "" "" "68.1" "58.1" "40.5" "51.4" "55.9" "47.5" "47.2" "57.8" "56.9" "64.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "13.245" "8" "2" "3" "2" "258" "28.8" "6.65" "12.12" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "0.912" "0.983" "0.981" "1.040" "0.874" "0.942" "1.043" "1.035" "0.987" "211.3" "192.7" "207.8" "207.2" "219.8" "184.6" "199.1" "220.5" "218.6" "208.6" "" "" "" "" "" "" "" "" "" "" "211.3" "163.0" "131.4" "151.1" "180.1" "143.4" "153.5" "189.6" "170.6" "187.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4942654517427891889" "False" "High" "IsMasterProtein" "Q9H6D7" "HAUS augmin-like complex subunit 4 OS=Homo sapiens OX=9606 GN=HAUS4 PE=1 SV=1" "0.000" "False" "13.242" "13" "5" "5" "5" "363" "42.4" "5.68" "13.85" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14735" "54930" "ENSG00000092036" "HAUS4" "B7WP17; D3DS34; hsa:54930; Q86T15; Q86T16; Q86U43; Q9H6D7; Q9NX59" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "0.946" "0.757" "1.074" "1.034" "0.730" "1.053" "0.931" "0.763" "0.833" "111.8" "105.8" "84.7" "120.1" "115.6" "81.6" "117.7" "104.1" "85.3" "93.2" "" "" "" "" "" "" "" "" "" "" "111.8" "89.5" "53.6" "87.6" "94.7" "63.4" "90.7" "89.5" "66.6" "83.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.000" "False" "13.240" "4" "3" "4" "3" "746" "85.3" "7.02" "10.74" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "Defective pyroptosis; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "19" "0" "0.978" "0.768" "0.985" "0.961" "0.884" "0.896" "1.014" "0.823" "0.960" "328.6" "321.2" "252.2" "323.6" "315.7" "290.4" "294.2" "333.2" "270.5" "315.4" "" "" "" "" "" "" "" "" "" "" "328.6" "271.8" "159.5" "236.0" "258.6" "225.5" "226.8" "286.5" "211.2" "283.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "13.239" "3" "4" "4" "4" "1435" "154.6" "6.76" "12.04" "4" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "1.019" "0.909" "0.989" "1.011" "0.933" "1.053" "1.028" "0.885" "0.990" "420.0" "428.0" "381.9" "415.1" "424.4" "392.0" "442.1" "431.8" "371.8" "415.7" "" "" "" "" "" "" "" "" "" "" "420.0" "362.1" "241.5" "302.7" "347.7" "304.5" "340.8" "371.3" "290.2" "373.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "13.227" "14" "4" "6" "4" "288" "32.3" "9.72" "18.93" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "" "HATs acetylate histones" "1" "0" "0.984" "0.849" "1.078" "0.986" "0.926" "1.075" "1.039" "0.908" "0.952" "283.9" "279.3" "240.9" "305.9" "279.8" "262.8" "305.3" "295.1" "257.8" "270.1" "" "" "" "" "" "" "" "" "" "" "283.9" "236.3" "152.3" "223.0" "229.2" "204.1" "235.3" "253.7" "201.2" "242.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "13.210" "10" "2" "8" "1" "208" "23.6" "5.54" "25.63" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "7" "0" "1.092" "1.896" "1.210" "1.113" "1.794" "1.321" "1.078" "1.740" "1.226" "98.0" "107.0" "185.7" "118.6" "109.0" "175.8" "129.4" "105.6" "170.4" "120.1" "" "" "" "" "" "" "" "" "" "" "98.0" "90.5" "117.4" "86.4" "89.3" "136.5" "99.7" "90.8" "133.0" "108.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "13.202" "10" "4" "5" "4" "542" "59.6" "9.35" "12.14" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "17" "0" "1.082" "1.061" "0.915" "0.996" "0.898" "0.978" "0.992" "0.879" "0.984" "195.5" "211.6" "207.4" "178.9" "194.7" "175.6" "191.3" "193.9" "171.9" "192.3" "" "" "" "" "" "" "" "" "" "" "195.5" "179.0" "131.1" "130.4" "159.5" "136.3" "147.4" "166.8" "134.1" "172.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.000" "False" "13.200" "5" "3" "3" "3" "672" "75.1" "6.24" "10.78" "3" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "" "Synthesis of Ketone Bodies" "1" "0" "1.070" "0.948" "1.228" "1.114" "0.927" "1.202" "1.102" "0.917" "1.085" "106.9" "114.4" "101.4" "131.3" "119.1" "99.2" "128.5" "117.8" "98.1" "116.0" "" "" "" "" "" "" "" "" "" "" "106.9" "96.8" "64.1" "95.8" "97.6" "77.0" "99.0" "101.3" "76.5" "104.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "13.198" "4" "3" "3" "3" "1121" "121.6" "6.87" "11.02" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "5" "0" "1.039" "0.871" "0.938" "1.107" "0.965" "1.012" "1.035" "0.892" "1.083" "124.3" "129.2" "108.3" "116.5" "137.5" "119.9" "125.7" "128.7" "110.8" "134.6" "" "" "" "" "" "" "" "" "" "" "124.3" "109.3" "68.5" "85.0" "112.7" "93.1" "96.9" "110.6" "86.5" "121.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "High" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.000" "False" "13.191" "7" "4" "4" "4" "619" "68.8" "7.44" "11.37" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "Ciliopathies" "" "1" "0" "1.074" "0.887" "0.957" "0.981" "1.017" "0.951" "0.897" "0.926" "1.118" "111.7" "119.9" "99.0" "106.9" "109.5" "113.5" "106.2" "100.1" "103.4" "124.8" "" "" "" "" "" "" "" "" "" "" "111.7" "101.5" "62.6" "77.9" "89.7" "88.2" "81.9" "86.1" "80.7" "112.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3933333122988886366" "False" "High" "IsMasterProtein" "Q6ZNJ1" "Neurobeachin-like protein 2 OS=Homo sapiens OX=9606 GN=NBEAL2 PE=1 SV=2" "0.000" "False" "13.183" "1" "3" "3" "3" "2754" "302.3" "6.38" "10.92" "3" "other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf02138, Pf14844, Pf15787, Pf16057, Pf20425, Pf20426" "23218" "ENSG00000160796" "NBEAL2" "hsa:23218; O60288; Q6P994; Q6UX91; Q6ZNJ1; Q8NAC9" "" "Neutrophil degranulation" "1" "0" "1.115" "0.622" "0.759" "1.072" "1.049" "1.032" "1.198" "1.276" "0.904" "18.3" "20.4" "11.4" "13.9" "19.6" "19.2" "18.9" "21.9" "23.3" "16.5" "" "" "" "" "" "" "" "" "" "" "18.3" "17.2" "7.2" "10.1" "16.1" "14.9" "14.6" "18.8" "18.2" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857975298597403350" "False" "High" "IsMasterProtein" "Q96N67" "Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4" "0.000" "False" "13.175" "2" "5" "5" "3" "2140" "242.4" "6.80" "11.82" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "85440" "ENSG00000116641" "DOCK7" "hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1" "4" "0" "1.011" "0.853" "0.961" "1.024" "0.896" "0.979" "1.045" "0.866" "0.955" "180.0" "181.9" "153.5" "172.9" "184.3" "161.2" "176.2" "188.0" "155.9" "171.9" "" "" "" "" "" "" "" "" "" "" "180.0" "153.9" "97.1" "126.1" "151.0" "125.2" "135.8" "161.6" "121.7" "154.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "13.151" "6" "2" "3" "2" "347" "38.3" "7.64" "11.87" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.026" "1.099" "1.066" "0.985" "1.033" "1.107" "1.162" "1.037" "1.082" "261.0" "267.7" "286.7" "278.2" "257.2" "269.6" "288.9" "303.1" "270.6" "282.4" "" "" "" "" "" "" "" "" "" "" "261.0" "226.5" "181.3" "202.8" "210.7" "209.4" "222.7" "260.6" "211.2" "253.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "13.107" "3" "3" "3" "3" "879" "99.3" "6.35" "9.59" "3" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "" "Regulation of pyruvate dehydrogenase (PDH) complex" "1" "0" "0.899" "0.964" "0.921" "0.923" "1.089" "0.932" "0.913" "1.082" "0.960" "250.2" "224.9" "241.2" "230.4" "230.9" "272.3" "233.2" "228.5" "270.6" "240.2" "" "" "" "" "" "" "" "" "" "" "250.2" "190.3" "152.5" "168.0" "189.2" "211.5" "179.7" "196.4" "211.2" "216.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "High" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.000" "False" "13.102" "3" "3" "3" "3" "1076" "115.0" "6.48" "9.24" "3" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "1.006" "0.852" "1.089" "1.023" "0.817" "1.086" "0.969" "0.761" "0.946" "61.9" "62.3" "52.8" "67.5" "63.4" "50.6" "67.3" "60.0" "47.1" "58.6" "" "" "" "" "" "" "" "" "" "" "61.9" "52.7" "33.4" "49.2" "51.9" "39.3" "51.9" "51.6" "36.8" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "High" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.000" "False" "13.090" "5" "5" "5" "5" "948" "106.9" "5.34" "14.03" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "1.052" "1.069" "1.123" "1.123" "1.134" "1.031" "1.118" "1.118" "1.047" "313.6" "329.7" "335.3" "352.3" "352.2" "355.7" "323.3" "350.5" "350.4" "328.4" "" "" "" "" "" "" "" "" "" "" "313.6" "279.0" "212.0" "256.9" "288.5" "276.2" "249.2" "301.4" "273.5" "295.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "13.086" "12" "4" "4" "4" "329" "34.3" "5.19" "12.56" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "0.929" "0.865" "1.018" "1.056" "1.055" "1.054" "1.021" "0.894" "0.952" "367.2" "341.1" "317.8" "373.8" "387.9" "387.2" "387.0" "374.8" "328.2" "349.6" "" "" "" "" "" "" "" "" "" "" "367.2" "288.6" "200.9" "272.5" "317.8" "300.7" "298.3" "322.2" "256.2" "314.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.000" "False" "13.069" "15" "5" "5" "5" "296" "33.2" "9.26" "15.11" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination; Mitochondrial protein degradation" "4" "0" "1.064" "1.037" "1.167" "1.043" "0.943" "1.137" "1.049" "0.915" "1.059" "209.9" "223.3" "217.7" "245.0" "218.8" "198.0" "238.7" "220.2" "192.0" "222.2" "" "" "" "" "" "" "" "" "" "" "209.9" "188.9" "137.7" "178.6" "179.3" "153.8" "184.0" "189.3" "149.9" "199.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "13.063" "3" "5" "5" "5" "2089" "226.5" "5.47" "14.33" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "9" "0" "1.009" "1.327" "0.863" "0.728" "0.849" "0.891" "1.025" "1.003" "0.779" "13.5" "13.6" "17.9" "11.6" "9.8" "11.4" "12.0" "13.8" "13.5" "10.5" "" "" "" "" "" "" "" "" "" "" "13.5" "11.5" "11.3" "8.5" "8.0" "8.9" "9.3" "11.9" "10.5" "9.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8029509769443933574" "False" "High" "IsMasterProtein" "Q7Z7A3" "Cytoplasmic tRNA 2-thiolation protein 1 OS=Homo sapiens OX=9606 GN=CTU1 PE=1 SV=1" "0.000" "False" "13.045" "9" "2" "2" "2" "348" "36.4" "9.20" "8.94" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01171, Pf16503" "90353" "ENSG00000142544" "CTU1" "A8K558; hsa:90353; Q7Z7A3; Q96GZ7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.100" "0.918" "1.080" "1.100" "0.994" "1.143" "0.892" "0.929" "0.955" "177.2" "195.0" "162.7" "191.4" "194.9" "176.2" "202.6" "158.1" "164.6" "169.2" "" "" "" "" "" "" "" "" "" "" "177.2" "164.9" "102.8" "139.6" "159.7" "136.8" "156.2" "135.9" "128.4" "152.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076863243069163850" "False" "High" "IsMasterProtein" "Q8WX93" "Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3" "0.000" "False" "13.044" "2" "3" "3" "3" "1383" "150.5" "7.09" "11.00" "3" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "23022" "ENSG00000129116" "PALLD" "B3KTG2; B5MD56; B7ZMM5; hsa:23022; Q7L3E0; Q7Z3W0; Q86WE8; Q8N1M2; Q8WX93; Q9UGA0; Q9UQF5; Q9Y2J6; Q9Y3E9" "" "" "0" "0" "0.920" "0.822" "0.911" "0.962" "0.969" "0.892" "0.968" "0.889" "0.919" "131.3" "120.9" "108.0" "119.6" "126.4" "127.2" "117.2" "127.1" "116.7" "120.7" "" "" "" "" "" "" "" "" "" "" "131.3" "102.2" "68.3" "87.2" "103.5" "98.8" "90.3" "109.3" "91.1" "108.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1694253408134936187" "False" "High" "IsMasterProtein" "P50452" "Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2" "0.000" "False" "13.026" "10" "3" "4" "3" "374" "42.7" "5.57" "14.15" "3" "cell adhesion;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity" "Pf00079" "5271" "ENSG00000166401" "SERPINB8" "B4DTW2; P50452; Q7Z2V6; Q8N178" "" "Dissolution of Fibrin Clot" "1" "0" "1.084" "1.229" "1.167" "1.043" "1.267" "1.000" "1.079" "1.048" "1.317" "114.2" "123.8" "140.3" "133.3" "119.1" "144.8" "114.2" "123.2" "119.7" "150.4" "" "" "" "" "" "" "" "" "" "" "114.2" "104.7" "88.7" "97.2" "97.6" "112.4" "88.0" "105.9" "93.5" "135.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8773052781393690194" "False" "High" "IsMasterProtein" "Q9Y6X4" "Soluble lamin-associated protein of 75 kDa OS=Homo sapiens OX=9606 GN=FAM169A PE=1 SV=2" "0.000" "False" "13.010" "7" "4" "6" "4" "670" "74.9" "4.60" "17.64" "4" "" "other membranes;nucleus" "" "" "26049" "ENSG00000198780" "FAM169A" "A8K1T9; hsa:26049; Q6MZT0; Q9H989; Q9Y6X4" "" "RHOF GTPase cycle" "1" "0" "1.031" "1.071" "0.997" "1.105" "1.037" "1.053" "1.044" "0.964" "1.116" "389.5" "401.5" "417.3" "388.4" "430.6" "404.1" "410.3" "406.6" "375.7" "434.8" "" "" "" "" "" "" "" "" "" "" "389.5" "339.7" "263.8" "283.2" "352.8" "313.8" "316.3" "349.6" "293.2" "390.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6229699224070924638" "False" "High" "IsMasterProtein" "Q13107" "Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3" "0.000" "False" "13.006" "4" "4" "4" "3" "963" "108.5" "5.71" "12.73" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14836" "7375" "ENSG00000114316" "USP4" "A8K6Y0; C9IY91; hsa:7375; O43452; O43453; Q08AK8; Q13107" "" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "4" "0" "0.793" "0.842" "0.976" "1.105" "0.776" "0.966" "0.942" "0.729" "0.926" "98.1" "77.8" "82.6" "95.8" "108.3" "76.1" "94.7" "92.4" "71.5" "90.8" "" "" "" "" "" "" "" "" "" "" "98.1" "65.8" "52.2" "69.8" "88.8" "59.1" "73.0" "79.5" "55.8" "81.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "12.995" "3" "3" "3" "3" "1091" "126.2" "6.99" "9.64" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.166" "0.802" "0.996" "1.180" "1.020" "1.077" "1.125" "0.889" "1.079" "158.1" "184.4" "126.7" "157.4" "186.5" "161.2" "170.2" "177.9" "140.5" "170.6" "" "" "" "" "" "" "" "" "" "" "158.1" "156.0" "80.1" "114.8" "152.8" "125.2" "131.2" "153.0" "109.7" "153.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "884505446193914017" "False" "High" "IsMasterProtein" "O43752" "Syntaxin-6 OS=Homo sapiens OX=9606 GN=STX6 PE=1 SV=1" "0.000" "False" "12.980" "13" "3" "5" "3" "255" "29.2" "4.93" "15.46" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf09177" "10228" "ENSG00000135823" "STX6" "B2R652; B4DR17; hsa:10228; O43752; Q5VY08; Q6FH83" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.035" "1.076" "1.163" "1.122" "1.089" "1.216" "1.247" "1.021" "1.126" "131.7" "136.3" "141.7" "153.1" "147.8" "143.4" "160.2" "164.3" "134.5" "148.2" "" "" "" "" "" "" "" "" "" "" "131.7" "115.3" "89.6" "111.6" "121.1" "111.3" "123.5" "141.2" "105.0" "133.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "12.970" "6" "6" "6" "6" "1008" "102.3" "8.06" "14.80" "6" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "MECP2 regulates neuronal receptors and channels" "3" "0" "0.906" "0.919" "0.929" "0.905" "0.961" "0.952" "0.903" "1.008" "0.952" "708.8" "642.3" "651.5" "658.2" "641.6" "681.0" "674.8" "640.2" "714.3" "674.9" "" "" "" "" "" "" "" "" "" "" "708.8" "543.4" "412.0" "479.9" "525.7" "528.9" "520.1" "550.4" "557.5" "606.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "12.963" "7" "2" "3" "2" "380" "42.1" "5.63" "12.56" "2" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "" "Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.031" "0.898" "1.056" "1.032" "0.903" "1.034" "1.138" "0.973" "1.002" "131.8" "135.8" "118.3" "139.1" "136.0" "119.0" "136.3" "149.9" "128.1" "132.0" "" "" "" "" "" "" "" "" "" "" "131.8" "114.9" "74.8" "101.4" "111.4" "92.4" "105.0" "128.9" "100.0" "118.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "12.962" "8" "4" "9" "2" "488" "55.3" "5.91" "26.75" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "30" "0" "0.815" "0.781" "0.904" "0.962" "0.913" "0.905" "0.806" "0.768" "0.844" "156.3" "127.4" "122.1" "141.3" "150.4" "142.7" "141.4" "126.0" "120.1" "131.9" "" "" "" "" "" "" "" "" "" "" "156.3" "107.7" "77.2" "103.0" "123.2" "110.8" "109.0" "108.4" "93.7" "118.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6843403857140785601" "False" "High" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "0.000" "False" "12.962" "9" "4" "4" "4" "392" "46.2" "8.72" "11.48" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "1.055" "1.092" "1.069" "1.186" "1.202" "1.206" "1.128" "1.108" "1.187" "155.7" "164.2" "169.9" "166.4" "184.6" "187.1" "187.7" "175.6" "172.4" "184.8" "" "" "" "" "" "" "" "" "" "" "155.7" "138.9" "107.4" "121.3" "151.3" "145.3" "144.7" "151.0" "134.6" "166.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479259144489451223" "False" "High" "IsMasterProtein" "Q96DG6" "Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1" "0.000" "False" "12.957" "13" "4" "5" "4" "245" "28.0" "7.18" "14.06" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01738" "134147" "ENSG00000164237" "CMBL" "D3DTC7; hsa:134147; Q8TED6; Q96DG6" "" "Phase I - Functionalization of compounds" "1" "0" "1.019" "1.063" "0.969" "0.998" "1.120" "1.057" "1.027" "1.025" "1.056" "310.6" "316.6" "330.3" "301.0" "310.0" "347.8" "328.2" "319.0" "318.4" "328.0" "" "" "" "" "" "" "" "" "" "" "310.6" "267.8" "208.8" "219.5" "254.0" "270.1" "253.0" "274.3" "248.5" "294.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "12.947" "9" "6" "8" "6" "719" "79.7" "5.45" "18.09" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "0.851" "1.171" "1.081" "0.801" "0.867" "1.129" "0.930" "0.927" "0.820" "43.7" "37.2" "51.2" "47.2" "35.0" "37.9" "49.3" "40.6" "40.5" "35.8" "" "" "" "" "" "" "" "" "" "" "43.7" "31.5" "32.3" "34.4" "28.7" "29.4" "38.0" "34.9" "31.6" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "12.947" "14" "2" "5" "2" "158" "18.0" "8.66" "20.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "SUMOylation of RNA binding proteins; Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "27" "0" "1.001" "0.984" "1.024" "0.959" "0.891" "0.963" "0.919" "0.942" "1.019" "734.2" "735.2" "722.2" "751.8" "704.5" "654.4" "707.3" "674.8" "691.5" "748.0" "" "" "" "" "" "" "" "" "" "" "734.2" "622.0" "456.6" "548.2" "577.2" "508.2" "545.2" "580.2" "539.7" "672.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "12.943" "6" "4" "4" "4" "898" "100.0" "6.11" "11.73" "4" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "0.865" "0.869" "0.903" "0.892" "0.795" "0.954" "1.008" "0.850" "0.840" "175.9" "152.2" "153.0" "158.9" "156.8" "139.9" "167.9" "177.3" "149.5" "147.8" "" "" "" "" "" "" "" "" "" "" "175.9" "128.8" "96.7" "115.9" "128.5" "108.7" "129.4" "152.4" "116.7" "132.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "12.926" "5" "4" "4" "4" "839" "94.6" "6.77" "13.07" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "1.095" "0.885" "1.015" "1.157" "0.916" "1.080" "1.135" "0.942" "1.089" "272.4" "298.3" "241.1" "276.3" "315.0" "249.6" "294.1" "309.1" "256.6" "296.6" "" "" "" "" "" "" "" "" "" "" "272.4" "252.4" "152.5" "201.5" "258.1" "193.8" "226.7" "265.8" "200.3" "266.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "12.923" "4" "2" "2" "2" "562" "60.5" "8.69" "9.13" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "1.103" "0.956" "1.166" "0.976" "1.046" "1.097" "1.023" "0.926" "1.059" "93.8" "103.5" "89.7" "109.4" "91.5" "98.1" "102.9" "96.0" "86.8" "99.3" "" "" "" "" "" "" "" "" "" "" "93.8" "87.6" "56.7" "79.7" "75.0" "76.2" "79.3" "82.5" "67.8" "89.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.000" "False" "12.917" "2" "3" "4" "2" "1386" "155.5" "7.71" "11.86" "3" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "0.646" "0.917" "0.761" "0.868" "0.779" "0.778" "0.872" "0.828" "0.887" "172.6" "111.6" "158.3" "131.3" "149.8" "134.4" "134.3" "150.6" "143.0" "153.1" "" "" "" "" "" "" "" "" "" "" "172.6" "94.4" "100.1" "95.7" "122.7" "104.4" "103.5" "129.5" "111.6" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "12.908" "22" "5" "9" "5" "184" "20.8" "5.31" "24.97" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "" "Pyruvate metabolism" "1" "0" "1.041" "1.128" "1.036" "1.073" "1.208" "1.229" "1.027" "1.089" "1.059" "365.8" "380.8" "412.7" "379.0" "392.5" "441.8" "449.4" "375.5" "398.5" "387.4" "" "" "" "" "" "" "" "" "" "" "365.8" "322.2" "260.9" "276.3" "321.6" "343.1" "346.4" "322.8" "311.1" "348.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370304273166594920" "False" "High" "IsMasterProtein" "O94906" "Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1" "0.000" "False" "12.900" "5" "5" "6" "5" "941" "106.9" "8.25" "14.76" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06424, Pf13181, Pf14559" "24148" "ENSG00000101161" "PRPF6" "B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.216" "0.964" "1.138" "1.137" "0.907" "1.203" "1.239" "0.852" "1.239" "39.7" "48.3" "38.2" "45.2" "45.1" "36.0" "47.7" "49.2" "33.8" "49.2" "" "" "" "" "" "" "" "" "" "" "39.7" "40.8" "24.2" "32.9" "37.0" "27.9" "36.8" "42.3" "26.4" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.000" "False" "12.896" "22" "4" "4" "4" "180" "20.6" "9.54" "13.14" "4" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "1.127" "1.199" "1.069" "1.215" "1.159" "1.084" "1.076" "1.164" "1.145" "337.5" "380.2" "404.7" "360.9" "410.2" "391.3" "365.8" "363.1" "392.7" "386.4" "" "" "" "" "" "" "" "" "" "" "337.5" "321.7" "255.9" "263.2" "336.1" "303.9" "281.9" "312.2" "306.5" "347.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "12.895" "12" "4" "4" "3" "286" "32.4" "6.55" "12.84" "4" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "1" "0.904" "0.794" "0.897" "1.009" "0.947" "0.965" "0.967" "0.953" "0.913" "153.8" "139.0" "122.0" "138.0" "155.1" "145.6" "148.3" "148.7" "146.5" "140.4" "" "" "" "" "" "" "" "" "" "" "153.8" "117.6" "77.2" "100.6" "127.1" "113.1" "114.3" "127.9" "114.3" "126.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "12.886" "10" "2" "2" "2" "261" "27.0" "6.54" "7.89" "2" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.177" "1.147" "1.070" "1.092" "0.975" "1.133" "1.324" "1.077" "1.378" "24.4" "28.7" "28.0" "26.1" "26.7" "23.8" "27.7" "32.3" "26.3" "33.7" "" "" "" "" "" "" "" "" "" "" "24.4" "24.3" "17.7" "19.1" "21.9" "18.5" "21.3" "27.8" "20.5" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "12.884" "2" "4" "5" "4" "1833" "193.9" "6.76" "10.82" "4" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "18" "0" "1.265" "1.001" "1.108" "1.123" "1.122" "1.472" "1.394" "1.018" "0.859" "50.1" "63.4" "50.2" "55.5" "56.3" "56.2" "73.8" "69.8" "51.0" "43.1" "" "" "" "" "" "" "" "" "" "" "50.1" "53.6" "31.7" "40.5" "46.1" "43.7" "56.9" "60.1" "39.8" "38.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1638288113087067454" "False" "High" "IsMasterProtein" "Q9NQG6" "Mitochondrial dynamics protein MIEF1 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1" "0.000" "False" "12.882" "6" "3" "3" "3" "463" "51.3" "7.64" "10.47" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf20266, Pf21297" "54471" "ENSG00000100335" "MIEF1" "hsa:54471; Q7L890; Q9BUI3; Q9NQG6" "" "" "0" "0" "0.997" "1.081" "1.068" "1.101" "1.003" "1.242" "1.214" "1.060" "1.044" "78.9" "78.8" "85.4" "84.3" "86.9" "79.2" "98.1" "95.8" "83.7" "82.5" "" "" "" "" "" "" "" "" "" "" "78.9" "66.6" "54.0" "61.5" "71.2" "61.5" "75.6" "82.4" "65.3" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "12.853" "4" "5" "5" "4" "1117" "124.5" "5.76" "14.21" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "1.260" "0.992" "1.428" "1.144" "1.099" "1.317" "1.145" "1.199" "1.100" "83.5" "105.3" "82.8" "119.2" "95.6" "91.8" "110.0" "95.6" "100.1" "91.9" "" "" "" "" "" "" "" "" "" "" "83.5" "89.0" "52.4" "86.9" "78.3" "71.3" "84.8" "82.2" "78.2" "82.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "12.848" "5" "4" "4" "4" "713" "80.6" "7.05" "12.99" "4" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "13q12.12 copy number variation" "" "1" "0" "1.010" "1.024" "0.995" "0.966" "0.994" "1.009" "1.069" "1.042" "1.071" "227.8" "230.2" "233.2" "226.7" "220.1" "226.5" "229.9" "243.5" "237.4" "243.9" "" "" "" "" "" "" "" "" "" "" "227.8" "194.7" "147.5" "165.3" "180.3" "175.9" "177.2" "209.3" "185.3" "219.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773776656278812315" "False" "High" "IsMasterProtein" "Q6DN90" "IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IQSEC1 PE=1 SV=1" "0.000" "False" "12.842" "4" "3" "4" "3" "963" "108.2" "6.93" "13.33" "3" "cell organization and biogenesis;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf16453" "9922" "ENSG00000144711" "IQSEC1" "A0A087WWK8; hsa:9922; O94863; Q6DN90; Q96D85" "EGF/EGFR signaling pathway" "" "1" "0" "1.038" "0.940" "0.907" "0.904" "0.968" "1.042" "0.992" "1.085" "1.041" "113.4" "117.7" "106.6" "102.8" "102.5" "109.8" "118.1" "112.5" "123.0" "118.1" "" "" "" "" "" "" "" "" "" "" "113.4" "99.6" "67.4" "75.0" "84.0" "85.2" "91.1" "96.7" "96.0" "106.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "12.828" "11" "5" "6" "5" "477" "54.1" "7.24" "11.85" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Ectoderm differentiation" "Mitochondrial tRNA aminoacylation" "2" "0" "0.594" "1.228" "1.066" "0.935" "0.910" "0.987" "0.894" "1.166" "1.005" "26.3" "15.6" "32.3" "28.1" "24.6" "24.0" "26.0" "23.5" "30.7" "26.4" "" "" "" "" "" "" "" "" "" "" "26.3" "13.2" "20.4" "20.5" "20.2" "18.6" "20.0" "20.2" "23.9" "23.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6158832266931892371" "False" "High" "IsMasterProtein" "Q01167" "Forkhead box protein K2 OS=Homo sapiens OX=9606 GN=FOXK2 PE=1 SV=3" "0.000" "False" "12.809" "7" "4" "4" "2" "660" "69.0" "9.54" "13.17" "4" "other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "3607" "ENSG00000141568" "FOXK2" "A6NEP5; hsa:3607; Q01167; Q13622; Q13623; Q13624" "" "UCH proteinases" "1" "0" "0.867" "0.981" "1.345" "1.221" "0.796" "0.982" "0.947" "0.798" "0.988" "51.1" "44.3" "50.1" "68.7" "62.4" "40.7" "50.2" "48.4" "40.8" "50.5" "" "" "" "" "" "" "" "" "" "" "51.1" "37.5" "31.7" "50.1" "51.1" "31.6" "38.7" "41.6" "31.8" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "12.807" "4" "3" "3" "3" "929" "103.6" "8.22" "7.98" "3" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "0.956" "0.975" "1.063" "0.789" "0.924" "0.937" "1.058" "0.994" "0.873" "100.9" "96.5" "98.4" "107.3" "79.6" "93.2" "94.5" "106.8" "100.3" "88.1" "" "" "" "" "" "" "" "" "" "" "100.9" "81.6" "62.2" "78.2" "65.2" "72.4" "72.9" "91.8" "78.3" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2011789362582396358" "False" "High" "IsMasterProtein" "Q9NSI8" "SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1" "0.000" "False" "12.804" "9" "3" "3" "3" "373" "41.7" "5.43" "11.86" "3" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07647, Pf07653, Pf12485" "64092" "ENSG00000155307" "SAMSN1" "B3KWJ3; F8WAA1; hsa:64092; Q8NFF7; Q9C041; Q9NSI8" "TYROBP causal network in microglia" "" "1" "0" "1.186" "1.113" "1.280" "1.112" "1.087" "1.134" "1.131" "1.085" "1.098" "146.2" "173.3" "162.6" "187.1" "162.5" "158.8" "165.7" "165.2" "158.6" "160.5" "" "" "" "" "" "" "" "" "" "" "146.2" "146.6" "102.8" "136.4" "133.2" "123.4" "127.7" "142.1" "123.8" "144.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.000" "False" "12.800" "17" "2" "3" "2" "188" "20.9" "5.44" "9.25" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "12.790" "18" "2" "3" "2" "122" "14.6" "9.38" "9.21" "2" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.028" "1.084" "1.111" "1.151" "1.130" "1.264" "1.233" "1.179" "1.051" "116.7" "119.9" "126.6" "129.7" "134.3" "131.9" "147.5" "143.9" "137.6" "122.7" "" "" "" "" "" "" "" "" "" "" "116.7" "101.5" "80.0" "94.5" "110.0" "102.4" "113.7" "123.7" "107.4" "110.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "12.789" "11" "3" "4" "3" "369" "39.2" "9.83" "13.57" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "2" "0" "1.077" "1.010" "1.071" "1.035" "0.851" "1.004" "0.929" "1.085" "1.029" "73.3" "79.0" "74.0" "78.5" "75.9" "62.4" "73.6" "68.1" "79.6" "75.5" "" "" "" "" "" "" "" "" "" "" "73.3" "66.8" "46.8" "57.3" "62.2" "48.5" "56.8" "58.6" "62.1" "67.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "12.785" "6" "4" "4" "4" "725" "81.3" "7.83" "11.33" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Microtubule cytoskeleton regulation" "Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "10" "0" "0.997" "0.722" "1.142" "1.054" "0.810" "0.967" "1.015" "0.710" "0.936" "149.6" "149.1" "108.0" "170.8" "157.6" "121.1" "144.6" "151.9" "106.3" "140.0" "" "" "" "" "" "" "" "" "" "" "149.6" "126.1" "68.3" "124.6" "129.1" "94.0" "111.5" "130.6" "82.9" "125.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "High" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.000" "False" "12.781" "6" "2" "3" "2" "424" "48.5" "5.55" "9.37" "2" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.856" "1.039" "0.884" "0.996" "0.879" "0.868" "0.872" "0.846" "1.028" "75.8" "64.9" "78.8" "67.1" "75.5" "66.7" "65.8" "66.1" "64.1" "77.9" "" "" "" "" "" "" "" "" "" "" "75.8" "54.9" "49.8" "48.9" "61.9" "51.8" "50.7" "56.9" "50.1" "70.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "12.768" "9" "3" "3" "3" "562" "63.6" "7.85" "10.26" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.013" "0.932" "1.101" "1.013" "0.778" "1.150" "1.059" "0.917" "1.010" "64.7" "65.6" "60.3" "71.3" "65.6" "50.4" "74.4" "68.6" "59.4" "65.4" "" "" "" "" "" "" "" "" "" "" "64.7" "55.5" "38.1" "52.0" "53.7" "39.1" "57.4" "59.0" "46.3" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "12.765" "8" "6" "6" "6" "603" "68.2" "8.91" "17.88" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "The role of GTSE1 in G2/M progression after G2 checkpoint; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Mitotic Telophase/Cytokinesis; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "30" "0" "1.018" "0.733" "1.054" "1.048" "0.734" "1.041" "1.103" "0.738" "1.039" "164.2" "167.2" "120.4" "173.1" "172.2" "120.6" "171.0" "181.1" "121.2" "170.7" "" "" "" "" "" "" "" "" "" "" "164.2" "141.4" "76.2" "126.2" "141.1" "93.6" "131.8" "155.7" "94.6" "153.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "12.739" "16" "6" "7" "6" "393" "42.8" "8.50" "21.42" "6" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "3" "0" "1.026" "1.062" "0.955" "0.902" "0.976" "0.893" "0.897" "0.984" "1.062" "528.9" "542.9" "561.9" "505.2" "476.9" "516.4" "472.4" "474.5" "520.4" "561.5" "" "" "" "" "" "" "" "" "" "" "528.9" "459.3" "355.3" "368.4" "390.7" "401.0" "364.1" "408.0" "406.2" "504.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "12.729" "18" "5" "6" "5" "301" "33.8" "8.00" "9.86" "5" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "" "Glycosphingolipid catabolism; The activation of arylsulfatases" "2" "0" "1.125" "0.850" "1.193" "1.162" "1.014" "1.272" "1.256" "0.964" "0.880" "177.8" "200.1" "151.1" "212.2" "206.6" "180.2" "226.3" "223.3" "171.4" "156.5" "" "" "" "" "" "" "" "" "" "" "177.8" "169.3" "95.6" "154.7" "169.2" "140.0" "174.4" "192.0" "133.8" "140.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "12.716" "20" "2" "3" "2" "133" "15.2" "5.22" "10.03" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.976" "0.869" "1.003" "1.181" "1.129" "0.918" "1.086" "1.019" "0.889" "62.2" "60.8" "54.1" "62.4" "73.5" "70.3" "57.1" "67.6" "63.4" "55.3" "" "" "" "" "" "" "" "" "" "" "62.2" "51.4" "34.2" "45.5" "60.2" "54.6" "44.0" "58.1" "49.5" "49.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "12.710" "14" "4" "4" "4" "274" "29.6" "8.32" "13.41" "4" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "Respiratory electron transport" "6" "0" "0.959" "0.872" "1.120" "0.949" "0.989" "1.009" "1.012" "1.046" "1.111" "81.2" "77.9" "70.8" "90.9" "77.1" "80.3" "82.0" "82.2" "84.9" "90.2" "" "" "" "" "" "" "" "" "" "" "81.2" "65.9" "44.8" "66.3" "63.2" "62.4" "63.2" "70.7" "66.3" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5410140500926118897" "False" "High" "IsMasterProtein" "Q96PU4" "E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1" "0.000" "False" "12.708" "6" "4" "5" "4" "802" "89.9" "8.21" "16.39" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "115426" "ENSG00000147854" "UHRF2" "hsa:115426; Q5VYR1; Q5VYR3; Q659C8; Q8TAG7; Q96PU4" "" "SUMOylation of transcription cofactors" "1" "0" "1.082" "0.866" "1.173" "1.088" "0.844" "1.137" "1.163" "0.970" "1.044" "114.2" "123.5" "98.9" "133.9" "124.3" "96.3" "129.9" "132.8" "110.8" "119.2" "" "" "" "" "" "" "" "" "" "" "114.2" "104.5" "62.6" "97.6" "101.8" "74.8" "100.1" "114.2" "86.5" "107.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6773616667088229623" "False" "High" "IsMasterProtein" "Q8N4Q0" "Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=PTGR3 PE=1 SV=1" "0.000" "False" "12.697" "9" "3" "4" "3" "377" "40.1" "8.18" "13.14" "3" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00107, Pf08240" "284273" "ENSG00000180011" "PTGR3" "A8KA15; B4DZ91; hsa:284273; Q8N4Q0" "" "" "0" "0" "1.106" "0.966" "1.223" "0.939" "0.818" "1.172" "0.976" "0.880" "0.834" "35.2" "38.9" "34.0" "43.0" "33.1" "28.8" "41.3" "34.4" "31.0" "29.4" "" "" "" "" "" "" "" "" "" "" "35.2" "32.9" "21.5" "31.4" "27.1" "22.4" "31.8" "29.6" "24.2" "26.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "12.696" "25" "2" "13" "2" "81" "9.1" "8.43" "38.67" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "7" "0" "0.985" "1.070" "1.002" "1.009" "1.115" "1.184" "0.997" "1.061" "1.071" "687.9" "677.6" "735.8" "689.4" "694.2" "767.1" "814.3" "686.1" "729.7" "736.7" "" "" "" "" "" "" "" "" "" "" "687.9" "573.2" "465.2" "502.7" "568.7" "595.7" "627.7" "589.9" "569.6" "662.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.000" "False" "12.691" "13" "4" "4" "4" "391" "44.0" "6.06" "11.58" "4" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "Ciliary landscape" "" "1" "0" "0.951" "0.936" "0.893" "0.930" "1.093" "0.888" "0.958" "1.075" "1.108" "198.2" "188.5" "185.6" "177.1" "184.3" "216.7" "176.0" "190.0" "213.1" "219.6" "" "" "" "" "" "" "" "" "" "" "198.2" "159.5" "117.3" "129.1" "151.0" "168.3" "135.7" "163.3" "166.4" "197.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "12.683" "4" "2" "3" "2" "733" "81.7" "7.88" "8.85" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "1.106" "1.062" "1.007" "1.042" "1.054" "1.100" "1.014" "1.069" "0.854" "90.6" "100.1" "96.2" "91.2" "94.4" "95.5" "99.7" "91.8" "96.8" "77.4" "" "" "" "" "" "" "" "" "" "" "90.6" "84.7" "60.8" "66.5" "77.3" "74.1" "76.8" "79.0" "75.6" "69.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.000" "False" "12.683" "7" "2" "3" "2" "311" "33.8" "5.47" "11.32" "2" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.898" "0.485" "1.049" "1.102" "0.730" "1.193" "0.976" "0.688" "0.762" "43.3" "38.9" "21.0" "45.5" "47.8" "31.6" "51.7" "42.3" "29.8" "33.0" "" "" "" "" "" "" "" "" "" "" "43.3" "32.9" "13.3" "33.2" "39.1" "24.6" "39.9" "36.4" "23.3" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8309198551146026693" "False" "High" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "0.000" "False" "12.674" "5" "4" "4" "4" "690" "77.6" "8.79" "11.34" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; O15226; Q4VC41; Q9UJ91" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "" "2" "0" "0.947" "0.725" "1.081" "1.114" "0.847" "1.124" "1.192" "0.762" "0.947" "78.3" "74.1" "56.8" "84.6" "87.2" "66.3" "88.0" "93.3" "59.6" "74.1" "" "" "" "" "" "" "" "" "" "" "78.3" "62.7" "35.9" "61.7" "71.4" "51.5" "67.8" "80.3" "46.5" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2891424664368030590" "False" "High" "IsMasterProtein" "Q8N6T3" "ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2" "0.000" "False" "12.630" "12" "4" "5" "4" "406" "44.6" "5.66" "14.24" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "55738" "ENSG00000101199" "ARFGAP1" "B7Z3U0; B7Z8H8; B7ZBI3; E1P5I9; E7EV62; hsa:55738; Q6PK71; Q8N6T3; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0" "IL-18 signaling pathway" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; XBP1(S) activates chaperone genes; Clathrin-mediated endocytosis" "5" "0" "0.947" "0.928" "0.955" "1.022" "1.007" "1.113" "0.968" "1.009" "0.992" "210.5" "199.3" "195.3" "200.9" "215.1" "211.8" "234.3" "203.7" "212.4" "208.8" "" "" "" "" "" "" "" "" "" "" "210.5" "168.6" "123.5" "146.5" "176.2" "164.5" "180.6" "175.1" "165.8" "187.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "12.624" "10" "4" "4" "4" "351" "38.4" "7.02" "13.05" "4" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Synthesis of PA" "2" "0" "1.036" "0.966" "1.082" "1.123" "0.936" "1.101" "0.991" "1.054" "1.199" "152.3" "157.9" "147.1" "164.9" "171.1" "142.6" "167.7" "151.0" "160.6" "182.6" "" "" "" "" "" "" "" "" "" "" "152.3" "133.6" "93.0" "120.2" "140.2" "110.7" "129.3" "129.8" "125.3" "164.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1754415614753477381" "False" "High" "IsMasterProtein" "Q86YV9" "BLOC-2 complex member HPS6 OS=Homo sapiens OX=9606 GN=HPS6 PE=1 SV=1" "0.000" "False" "12.622" "6" "4" "5" "4" "775" "82.9" "6.28" "15.05" "4" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15702, Pf20468" "79803" "ENSG00000166189" "HPS6" "Q5VV69; Q86YV9; Q9H685" "" "" "0" "0" "1.017" "0.725" "1.016" "1.021" "0.835" "1.033" "1.047" "0.875" "0.980" "188.6" "191.7" "136.7" "191.7" "192.6" "157.5" "194.8" "197.4" "165.1" "184.8" "" "" "" "" "" "" "" "" "" "" "188.6" "162.2" "86.4" "139.8" "157.8" "122.3" "150.2" "169.7" "128.8" "166.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "12.619" "9" "4" "4" "4" "495" "55.5" "8.27" "13.03" "4" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "0.936" "0.864" "0.792" "1.104" "0.995" "0.934" "1.019" "1.029" "0.876" "98.0" "91.7" "84.6" "77.6" "108.2" "97.4" "91.5" "99.9" "100.8" "85.9" "" "" "" "" "" "" "" "" "" "" "98.0" "77.6" "53.5" "56.6" "88.7" "75.7" "70.5" "85.9" "78.7" "77.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.000" "False" "12.600" "15" "3" "5" "3" "214" "24.7" "4.93" "10.42" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "1.004" "0.932" "1.036" "1.043" "0.918" "1.173" "1.011" "0.928" "0.993" "102.9" "103.3" "95.9" "106.6" "107.4" "94.4" "120.7" "104.1" "95.5" "102.2" "" "" "" "" "" "" "" "" "" "" "102.9" "87.4" "60.6" "77.8" "88.0" "73.3" "93.0" "89.5" "74.5" "91.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "12.589" "8" "2" "3" "2" "237" "26.8" "6.87" "10.85" "2" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "" "Mitochondrial RNA degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "12.582" "5" "3" "3" "3" "572" "61.2" "6.67" "9.60" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "Integrin-mediated cell adhesion; Focal adhesion" "" "2" "0" "0.923" "0.927" "1.051" "0.987" "0.961" "1.126" "0.948" "1.000" "0.916" "317.6" "293.3" "294.5" "333.9" "313.4" "305.1" "357.6" "301.2" "317.7" "291.1" "" "" "" "" "" "" "" "" "" "" "317.6" "248.1" "186.2" "243.5" "256.7" "236.9" "275.6" "259.0" "248.0" "261.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "12.577" "20" "4" "5" "4" "261" "28.0" "8.05" "13.63" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "1.057" "0.844" "1.027" "1.037" "0.936" "1.066" "0.926" "0.871" "0.867" "141.7" "149.8" "119.5" "145.4" "147.0" "132.5" "151.0" "131.2" "123.4" "122.8" "" "" "" "" "" "" "" "" "" "" "141.7" "126.7" "75.6" "106.0" "120.4" "102.9" "116.4" "112.8" "96.3" "110.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6312094574811705899" "False" "High" "IsMasterProtein" "Q3L8U1" "Chromodomain-helicase-DNA-binding protein 9 OS=Homo sapiens OX=9606 GN=CHD9 PE=1 SV=2" "0.000" "False" "12.574" "1" "2" "3" "1" "2897" "325.8" "7.01" "9.60" "2" "cell organization and biogenesis" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "80205" "ENSG00000177200" "CHD9" "B2RTU2; B9ZVQ0; hsa:80205; O15025; Q1WF12; Q3L8U1; Q6DTK9; Q9H9V7; Q9UHM2" "" "Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "12.565" "12" "3" "3" "3" "318" "35.5" "5.94" "12.35" "3" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "" "Ubiquinol biosynthesis" "1" "0" "0.934" "1.065" "1.021" "1.006" "1.029" "1.064" "0.987" "1.000" "1.005" "271.8" "253.8" "289.3" "277.5" "273.4" "279.7" "289.1" "268.1" "271.8" "273.0" "" "" "" "" "" "" "" "" "" "" "271.8" "214.7" "183.0" "202.4" "224.0" "217.2" "222.9" "230.6" "212.1" "245.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760728246443025630" "False" "High" "IsMasterProtein" "Q99707" "Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2" "0.000" "False" "12.564" "2" "3" "3" "3" "1265" "140.4" "5.58" "8.72" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00809, Pf02310, Pf02574, Pf02607, Pf02965" "4548" "ENSG00000116984" "MTR" "A1L4N8; A9Z1W4; B7ZLW7; B9EGF7; hsa:4548; Q99707; Q99713; Q99723" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility; Spina bifida" "RHOH GTPase cycle; Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "19" "0" "1.141" "0.827" "1.094" "1.121" "0.909" "1.077" "0.984" "0.985" "1.044" "146.6" "167.2" "121.3" "160.3" "164.3" "133.3" "157.9" "144.2" "144.3" "153.1" "" "" "" "" "" "" "" "" "" "" "146.6" "141.4" "76.7" "116.9" "134.6" "103.5" "121.7" "124.0" "112.7" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "12.564" "12" "3" "3" "3" "352" "37.4" "8.72" "9.93" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1095568573092082412" "False" "High" "IsMasterProtein" "Q16762" "Thiosulfate sulfurtransferase OS=Homo sapiens OX=9606 GN=TST PE=1 SV=4" "0.000" "False" "12.551" "12" "3" "3" "3" "297" "33.4" "7.25" "8.78" "3" "other metabolic processes;transport;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00581" "7263" "ENSG00000128311" "TST" "B3KRM1; hsa:7263; Q16762; Q6IB06" "" "Sulfide oxidation to sulfate" "2" "0" "1.084" "0.990" "1.197" "1.051" "1.079" "1.116" "1.091" "1.039" "1.144" "92.4" "100.1" "91.4" "110.6" "97.1" "99.7" "103.1" "100.8" "96.0" "105.7" "" "" "" "" "" "" "" "" "" "" "92.4" "84.7" "57.8" "80.6" "79.6" "77.4" "79.5" "86.7" "74.9" "95.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "12.512" "5" "6" "6" "6" "1123" "128.6" "6.32" "13.78" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "1.076" "1.359" "1.125" "1.195" "1.374" "1.237" "1.257" "1.327" "1.156" "72.7" "78.3" "98.9" "81.8" "86.9" "99.9" "90.0" "91.5" "96.5" "84.1" "" "" "" "" "" "" "" "" "" "" "72.7" "66.2" "62.5" "59.7" "71.2" "77.6" "69.4" "78.6" "75.4" "75.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2639950246168757671" "False" "High" "IsMasterProtein" "P16591" "Tyrosine-protein kinase Fer OS=Homo sapiens OX=9606 GN=FER PE=1 SV=2" "0.000" "False" "12.487" "5" "5" "5" "5" "822" "94.6" "7.14" "14.87" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00611, Pf07714" "2241" "ENSG00000151422" "FER" "B2RCR4; B4DSQ2; H2FLB8; hsa:2241; P16591" "" "Signaling by SCF-KIT" "1" "0" "1.048" "0.861" "1.139" "1.039" "0.824" "1.080" "1.064" "0.848" "1.015" "265.0" "277.7" "228.0" "301.8" "275.3" "218.4" "286.2" "282.0" "224.8" "269.0" "" "" "" "" "" "" "" "" "" "" "265.0" "235.0" "144.2" "220.0" "225.5" "169.6" "220.6" "242.4" "175.5" "241.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "12.485" "5" "4" "4" "4" "816" "91.3" "6.25" "11.42" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "" "Synthesis of PIPs at the Golgi membrane" "1" "0" "0.875" "0.871" "0.916" "0.915" "0.953" "1.009" "1.022" "0.851" "0.817" "135.7" "118.7" "118.2" "124.3" "124.2" "129.3" "136.9" "138.7" "115.5" "110.9" "" "" "" "" "" "" "" "" "" "" "135.7" "100.4" "74.7" "90.6" "101.8" "100.4" "105.5" "119.2" "90.2" "99.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "12.483" "10" "2" "3" "2" "225" "26.1" "5.66" "10.28" "2" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.103" "1.277" "1.198" "1.114" "1.291" "1.254" "1.158" "1.386" "1.101" "95.5" "105.4" "122.0" "114.5" "106.4" "123.4" "119.8" "110.6" "132.4" "105.2" "" "" "" "" "" "" "" "" "" "" "95.5" "89.2" "77.2" "83.5" "87.2" "95.8" "92.4" "95.1" "103.4" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "12.478" "6" "3" "3" "3" "657" "75.6" "4.98" "10.56" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.125" "0.910" "1.247" "1.290" "0.979" "1.097" "1.177" "1.005" "0.962" "72.4" "81.5" "65.9" "90.4" "93.5" "70.9" "79.5" "85.2" "72.8" "69.7" "" "" "" "" "" "" "" "" "" "" "72.4" "69.0" "41.7" "65.9" "76.6" "55.1" "61.2" "73.3" "56.8" "62.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "12.453" "4" "3" "4" "2" "717" "81.6" "7.14" "11.61" "3" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.050" "1.208" "1.209" "1.127" "1.197" "1.349" "1.289" "1.357" "1.103" "158.1" "166.0" "191.0" "191.1" "178.1" "189.2" "213.2" "203.7" "214.5" "174.4" "" "" "" "" "" "" "" "" "" "" "158.1" "140.4" "120.7" "139.3" "145.9" "146.9" "164.3" "175.2" "167.4" "156.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "12.441" "6" "3" "4" "3" "529" "57.2" "5.19" "10.86" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "7" "0" "1.115" "1.064" "1.157" "1.169" "0.629" "0.974" "0.783" "0.841" "1.318" "22.3" "24.9" "23.7" "25.8" "26.1" "14.0" "21.7" "17.5" "18.8" "29.4" "" "" "" "" "" "" "" "" "" "" "22.3" "21.1" "15.0" "18.8" "21.4" "10.9" "16.7" "15.0" "14.6" "26.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7424972638177503000" "False" "High" "IsMasterProtein" "Q5T1C6" "Acyl-coenzyme A thioesterase THEM4 OS=Homo sapiens OX=9606 GN=THEM4 PE=1 SV=1" "0.000" "False" "12.440" "15" "3" "5" "3" "240" "27.1" "8.28" "13.89" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf03061" "117145" "ENSG00000159445" "THEM4" "B2RBX2; hsa:117145; Q5T1C6; Q96KR2" "PI3K-Akt signaling pathway" "Mitochondrial Fatty Acid Beta-Oxidation; CD28 dependent PI3K/Akt signaling; Activation of AKT2; VEGFR2 mediated vascular permeability; Negative regulation of the PI3K/AKT network" "7" "0" "0.927" "1.262" "0.897" "0.859" "1.045" "0.898" "1.012" "0.993" "1.003" "214.3" "198.6" "270.4" "192.2" "184.0" "223.8" "192.5" "216.8" "212.7" "214.9" "" "" "" "" "" "" "" "" "" "" "214.3" "168.0" "171.0" "140.1" "150.7" "173.8" "148.4" "186.4" "166.0" "193.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908958946430001431" "False" "High" "IsMasterProtein" "O60333" "Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B PE=1 SV=5" "0.000" "False" "12.430" "2" "3" "3" "2" "1816" "204.3" "5.60" "7.87" "3" "cell-cell signaling;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "23095" "ENSG00000054523" "KIF1B" "A6NFS8; A6NKQ4; hsa:23095; O60333; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280" "Intracellular trafficking proteins involved in CMT neuropathy" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "1.078" "1.106" "1.181" "1.173" "1.185" "1.132" "1.118" "0.880" "1.245" "37.5" "40.4" "41.5" "44.3" "44.0" "44.5" "42.5" "42.0" "33.0" "46.7" "" "" "" "" "" "" "" "" "" "" "37.5" "34.2" "26.2" "32.3" "36.1" "34.5" "32.7" "36.1" "25.8" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "12.413" "12" "3" "5" "2" "282" "31.3" "9.83" "17.38" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.041" "1.087" "0.914" "0.819" "0.719" "0.638" "0.730" "0.998" "0.969" "394.7" "411.0" "429.2" "360.5" "323.1" "283.7" "251.9" "288.0" "394.0" "382.5" "" "" "" "" "" "" "" "" "" "" "394.7" "347.7" "271.4" "262.9" "264.7" "220.3" "194.1" "247.6" "307.5" "343.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "12.396" "10" "3" "3" "3" "427" "47.2" "5.34" "10.12" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Interferon gamma signaling; Interferon alpha/beta signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "38" "0" "0.998" "0.874" "1.378" "1.000" "0.749" "1.171" "0.991" "1.103" "0.881" "36.0" "35.9" "31.5" "49.6" "36.0" "27.0" "42.2" "35.7" "39.7" "31.7" "" "" "" "" "" "" "" "" "" "" "36.0" "30.4" "19.9" "36.2" "29.5" "21.0" "32.5" "30.7" "31.0" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "12.374" "6" "3" "3" "3" "456" "52.1" "6.21" "10.29" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "1p36 copy number variation syndrome" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.970" "0.984" "0.969" "0.969" "0.911" "1.081" "0.963" "0.973" "1.009" "274.1" "265.9" "269.8" "265.6" "265.5" "249.8" "296.3" "264.0" "266.8" "276.5" "" "" "" "" "" "" "" "" "" "" "274.1" "225.0" "170.6" "193.7" "217.5" "194.0" "228.4" "227.0" "208.3" "248.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3617199734258832058" "False" "High" "IsMasterProtein" "Q9BZQ8" "Protein Niban 1 OS=Homo sapiens OX=9606 GN=NIBAN1 PE=1 SV=1" "0.000" "False" "12.357" "4" "4" "4" "4" "928" "103.1" "4.78" "9.40" "4" "stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "" "116496" "ENSG00000135842" "NIBAN1" "hsa:116496; Q2TTR2; Q5TEM8; Q8TEI5; Q9BZQ8; Q9H593; Q9H9Y8; Q9HCB9" "" "" "0" "0" "1.193" "1.152" "1.010" "1.093" "1.082" "1.061" "1.070" "1.096" "1.086" "130.0" "155.1" "149.8" "131.3" "142.1" "140.7" "137.8" "139.1" "142.4" "141.2" "" "" "" "" "" "" "" "" "" "" "130.0" "131.2" "94.7" "95.7" "116.4" "109.3" "106.3" "119.6" "111.2" "127.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "12.350" "8" "3" "3" "3" "351" "39.0" "6.16" "11.72" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "0.927" "0.840" "0.978" "0.839" "0.893" "0.960" "0.915" "0.906" "0.848" "382.2" "354.5" "321.2" "373.7" "320.7" "341.4" "366.9" "349.6" "346.4" "324.0" "" "" "" "" "" "" "" "" "" "" "382.2" "299.9" "203.1" "272.5" "262.7" "265.1" "282.8" "300.6" "270.4" "291.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "584714024089658403" "False" "High" "IsMasterProtein" "Q5XPI4" "E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1" "0.000" "False" "12.341" "3" "4" "4" "4" "1314" "148.4" "6.74" "11.85" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf13920" "63891" "ENSG00000164068" "RNF123" "A1L4Q3; A6NLS5; hsa:63891; Q5I022; Q5XPI4; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2" "" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases" "2" "0" "1.089" "0.830" "1.027" "1.124" "1.082" "1.221" "1.125" "1.441" "0.984" "98.6" "107.5" "81.8" "101.3" "110.9" "106.7" "120.5" "110.9" "142.2" "97.0" "" "" "" "" "" "" "" "" "" "" "98.6" "90.9" "51.7" "73.8" "90.8" "82.9" "92.9" "95.4" "111.0" "87.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "12.336" "14" "3" "3" "3" "254" "27.9" "6.83" "9.86" "3" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "" "Sulfide oxidation to sulfate" "1" "0" "1.256" "1.203" "0.945" "0.954" "1.084" "1.185" "1.045" "1.901" "1.487" "15.6" "19.6" "18.7" "14.7" "14.9" "16.9" "18.5" "16.3" "29.6" "23.2" "" "" "" "" "" "" "" "" "" "" "15.6" "16.6" "11.9" "10.7" "12.2" "13.1" "14.2" "14.0" "23.1" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "12.313" "9" "4" "5" "4" "439" "49.4" "4.82" "13.60" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.879" "0.811" "1.007" "1.000" "0.913" "0.946" "0.839" "1.233" "1.192" "27.0" "23.7" "21.9" "27.2" "27.0" "24.7" "25.6" "22.7" "33.3" "32.2" "" "" "" "" "" "" "" "" "" "" "27.0" "20.1" "13.9" "19.8" "22.1" "19.2" "19.7" "19.5" "26.0" "29.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "12.312" "17" "5" "6" "5" "317" "34.3" "5.97" "13.29" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "High" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.000" "False" "12.307" "8" "3" "4" "3" "358" "39.4" "4.86" "12.72" "3" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "0.955" "0.861" "0.818" "0.940" "0.933" "0.823" "0.877" "0.905" "0.868" "347.5" "332.1" "299.3" "284.2" "326.8" "324.4" "286.1" "304.7" "314.4" "301.6" "" "" "" "" "" "" "" "" "" "" "347.5" "280.9" "189.3" "207.2" "267.7" "251.9" "220.6" "262.0" "245.4" "271.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "12.303" "5" "4" "4" "4" "747" "86.1" "6.62" "9.55" "4" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "" "Synthesis of PIPs at the early endosome membrane" "1" "0" "1.066" "1.072" "1.136" "1.101" "1.090" "1.047" "1.065" "1.074" "0.970" "264.5" "282.0" "283.7" "300.6" "291.3" "288.5" "276.9" "281.8" "284.2" "256.6" "" "" "" "" "" "" "" "" "" "" "264.5" "238.6" "179.4" "219.2" "238.7" "224.0" "213.4" "242.3" "221.8" "230.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.000" "False" "12.296" "28" "3" "5" "3" "136" "15.8" "10.56" "12.27" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.899" "1.377" "0.981" "1.138" "1.443" "1.138" "1.382" "1.424" "1.081" "164.8" "148.2" "226.9" "161.6" "187.5" "237.8" "187.5" "227.6" "234.6" "178.2" "" "" "" "" "" "" "" "" "" "" "164.8" "125.4" "143.5" "117.8" "153.7" "184.7" "144.6" "195.7" "183.1" "160.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "12.279" "14" "5" "7" "4" "273" "33.2" "10.35" "19.91" "5" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.149" "1.357" "1.096" "1.138" "1.268" "1.113" "1.043" "1.272" "1.098" "224.6" "258.0" "304.7" "246.2" "255.6" "284.7" "250.0" "234.3" "285.6" "246.7" "" "" "" "" "" "" "" "" "" "" "224.6" "218.3" "192.7" "179.5" "209.5" "221.1" "192.7" "201.4" "222.9" "221.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.000" "False" "12.276" "24" "4" "4" "4" "165" "17.9" "7.44" "12.56" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "17" "0" "0.759" "0.757" "0.856" "0.760" "0.730" "0.690" "0.772" "1.036" "0.795" "215.4" "163.5" "163.0" "184.4" "163.6" "157.2" "148.7" "166.4" "223.0" "171.2" "" "" "" "" "" "" "" "" "" "" "215.4" "138.3" "103.1" "134.5" "134.1" "122.1" "114.6" "143.0" "174.1" "153.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "12.266" "9" "3" "3" "3" "327" "35.6" "7.97" "10.32" "3" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.065" "0.961" "1.091" "1.038" "0.898" "1.014" "1.039" "0.896" "1.065" "253.8" "270.4" "243.9" "277.0" "263.5" "227.8" "257.3" "263.7" "227.3" "270.2" "" "" "" "" "" "" "" "" "" "" "253.8" "228.7" "154.2" "202.0" "215.9" "176.9" "198.3" "226.7" "177.5" "242.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "12.241" "18" "3" "3" "3" "202" "21.2" "5.15" "12.14" "3" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.018" "0.885" "1.072" "1.022" "0.983" "0.942" "0.777" "0.981" "1.402" "34.4" "35.1" "30.5" "36.9" "35.2" "33.8" "32.4" "26.7" "33.8" "48.3" "" "" "" "" "" "" "" "" "" "" "34.4" "29.7" "19.3" "26.9" "28.8" "26.3" "25.0" "23.0" "26.4" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "12.220" "3" "4" "4" "4" "1071" "120.8" "6.70" "13.11" "4" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "" "RHO GTPases Activate Formins; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "8" "0" "1.049" "1.161" "1.111" "1.118" "1.032" "1.138" "1.142" "1.026" "1.061" "360.1" "377.8" "418.1" "400.1" "402.8" "371.8" "409.7" "411.2" "369.5" "381.9" "" "" "" "" "" "" "" "" "" "" "360.1" "319.6" "264.4" "291.7" "330.0" "288.7" "315.8" "353.6" "288.5" "343.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2514407203909916173" "False" "High" "IsMasterProtein" "O95363" "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" "0.000" "False" "12.217" "5" "2" "5" "2" "451" "52.3" "7.46" "15.67" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf03147" "10667" "ENSG00000145982" "FARS2" "B2R664; hsa:10667; O95363; Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.040" "1.040" "1.002" "1.040" "0.995" "0.990" "1.058" "1.050" "0.941" "229.0" "238.2" "238.1" "229.5" "238.1" "227.8" "226.8" "242.3" "240.4" "215.4" "" "" "" "" "" "" "" "" "" "" "229.0" "201.5" "150.6" "167.4" "195.1" "176.9" "174.8" "208.3" "187.6" "193.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624211832406913783" "False" "High" "IsMasterProtein" "P15884" "Transcription factor 4 OS=Homo sapiens OX=9606 GN=TCF4 PE=1 SV=3" "0.000" "False" "12.204" "5" "3" "3" "1" "667" "71.3" "7.01" "10.45" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6925" "ENSG00000196628" "TCF4" "B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4; G0LNU5; G0LNU8; G0LNU9; G0LNV0; G0LNV1; G0LNV2; H3BPQ1; hsa:6925; P15884; Q08AP2; Q08AP3; Q15439; Q15440; Q15441" "Neural crest differentiation; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Development of pulmonary dendritic cells and macrophage subsets; Rett syndrome; Gastrin signaling pathway; Neurogenesis regulation in the olfactory epithelium" "Myogenesis" "10" "2" "0.864" "0.690" "0.990" "0.998" "0.797" "1.109" "0.989" "0.641" "0.781" "336.3" "290.7" "232.1" "332.9" "335.5" "267.9" "373.1" "332.5" "215.5" "262.8" "" "" "" "" "" "" "" "" "" "" "336.3" "245.9" "146.8" "242.7" "274.9" "208.0" "287.6" "285.9" "168.2" "236.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "12.201" "16" "3" "4" "3" "270" "31.3" "7.47" "14.02" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "5" "0" "0.856" "0.950" "1.105" "1.114" "0.991" "1.198" "1.068" "0.970" "0.975" "145.7" "124.7" "138.4" "160.9" "162.2" "144.4" "174.5" "155.6" "141.3" "142.0" "" "" "" "" "" "" "" "" "" "" "145.7" "105.5" "87.5" "117.3" "132.9" "112.1" "134.5" "133.8" "110.3" "127.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5383054079404854662" "False" "High" "IsMasterProtein" "P84022" "Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1" "0.000" "False" "12.186" "7" "3" "4" "2" "425" "48.1" "7.15" "12.51" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4088" "ENSG00000166949" "SMAD3" "A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383; hsa:4088; O09064; O09144; O14510; O35273; P84022; Q92940; Q93002; Q9GKR4" "Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; GDNF signaling; Urotensin-II-mediated signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Ub-specific processing proteases; Formation of axial mesoderm; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; Interleukin-37 signaling; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "56" "0" "0.972" "0.988" "1.050" "1.016" "1.074" "1.131" "1.110" "1.089" "1.012" "133.2" "129.4" "131.5" "139.8" "135.3" "143.0" "150.6" "147.8" "145.1" "134.7" "" "" "" "" "" "" "" "" "" "" "133.2" "109.4" "83.1" "102.0" "110.9" "111.1" "116.1" "127.1" "113.2" "121.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4906938189869504573" "False" "High" "IsMasterProtein" "Q6GQQ9" "OTU domain-containing protein 7B OS=Homo sapiens OX=9606 GN=OTUD7B PE=1 SV=1" "0.000" "False" "12.177" "4" "3" "3" "3" "843" "92.5" "6.71" "9.95" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338, Pf14555" "56957" "ENSG00000264522" "OTUD7B" "B7Z643; D3DUZ8; hsa:56957; Q5SZ60; Q6GQQ9; Q8WWA7; Q9NQ53; Q9UFF4" "TNF-alpha signaling pathway; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling" "6" "0" "0.999" "0.860" "1.044" "1.086" "0.929" "1.075" "1.011" "0.980" "0.971" "232.4" "232.2" "200.0" "242.6" "252.5" "215.9" "249.9" "235.0" "227.7" "225.7" "" "" "" "" "" "" "" "" "" "" "232.4" "196.4" "126.4" "176.9" "206.9" "167.7" "192.6" "202.1" "177.7" "203.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "12.175" "7" "4" "4" "4" "498" "56.9" "7.72" "13.57" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "" "Interferon gamma signaling" "1" "0" "1.001" "0.794" "0.959" "0.846" "0.736" "0.919" "0.858" "0.796" "0.981" "73.1" "73.2" "58.0" "70.1" "61.9" "53.8" "67.2" "62.8" "58.2" "71.8" "" "" "" "" "" "" "" "" "" "" "73.1" "61.9" "36.7" "51.1" "50.7" "41.8" "51.8" "54.0" "45.4" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "12.168" "10" "3" "5" "3" "369" "40.9" "5.36" "17.67" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.103" "1.024" "1.064" "0.992" "1.137" "0.951" "1.044" "1.150" "1.058" "253.3" "279.4" "259.5" "269.5" "251.4" "288.1" "241.0" "264.5" "291.3" "268.0" "" "" "" "" "" "" "" "" "" "" "253.3" "236.4" "164.1" "196.5" "206.0" "223.7" "185.8" "227.4" "227.4" "240.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "12.155" "12" "4" "4" "4" "346" "36.2" "8.79" "12.50" "4" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "3" "0" "0.937" "0.836" "1.013" "0.935" "0.838" "1.010" "0.955" "0.998" "1.003" "117.7" "110.3" "98.3" "119.2" "110.1" "98.6" "118.9" "112.4" "117.5" "118.1" "" "" "" "" "" "" "" "" "" "" "117.7" "93.3" "62.2" "86.9" "90.2" "76.6" "91.7" "96.7" "91.7" "106.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "12.144" "13" "1" "2" "1" "109" "11.6" "7.78" "9.20" "1" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "0.775" "0.718" "0.947" "0.963" "0.872" "1.058" "0.860" "0.904" "1.060" "70.9" "54.9" "50.9" "67.2" "68.3" "61.8" "75.0" "61.0" "64.1" "75.2" "" "" "" "" "" "" "" "" "" "" "70.9" "46.5" "32.2" "49.0" "56.0" "48.0" "57.8" "52.4" "50.0" "67.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "12.135" "11" "3" "3" "3" "310" "33.5" "5.54" "11.75" "3" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "Estrogen-dependent gene expression" "3" "0" "0.944" "0.820" "1.020" "0.971" "0.863" "1.040" "0.934" "0.833" "0.899" "328.6" "310.1" "269.5" "335.3" "319.1" "283.6" "341.6" "306.8" "273.6" "295.2" "" "" "" "" "" "" "" "" "" "" "328.6" "262.3" "170.4" "244.5" "261.4" "220.3" "263.4" "263.8" "213.6" "265.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "12.128" "3" "3" "4" "3" "1192" "129.9" "4.50" "10.32" "3" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "Axonal growth inhibition (RHOA activation)" "7" "0" "0.792" "0.999" "0.947" "0.808" "0.885" "0.912" "0.879" "0.909" "0.756" "95.9" "75.9" "95.7" "90.8" "77.5" "84.8" "87.4" "84.2" "87.1" "72.4" "" "" "" "" "" "" "" "" "" "" "95.9" "64.2" "60.5" "66.2" "63.5" "65.9" "67.4" "72.4" "68.0" "65.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "High" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.000" "False" "12.121" "10" "3" "4" "3" "351" "38.0" "7.88" "12.66" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.190" "1.008" "1.108" "1.059" "1.117" "1.068" "0.994" "1.032" "0.978" "107.8" "128.3" "108.6" "119.4" "114.1" "120.3" "115.1" "107.1" "111.2" "105.4" "" "" "" "" "" "" "" "" "" "" "107.8" "108.5" "68.7" "87.1" "93.5" "93.5" "88.7" "92.1" "86.8" "94.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1378614036355870767" "False" "High" "IsMasterProtein" "Q9UIV1" "CCR4-NOT transcription complex subunit 7 OS=Homo sapiens OX=9606 GN=CNOT7 PE=1 SV=3" "0.000" "False" "12.120" "5" "1" "2" "1" "285" "32.7" "4.84" "8.16" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "29883" "ENSG00000198791" "CNOT7" "A8MZM5; B3KMP1; B3KN35; D3DSP6; G3V108; hsa:29883; Q7Z530; Q9UIV1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.020" "0.774" "0.971" "0.982" "0.950" "1.139" "1.129" "0.967" "1.099" "47.6" "48.6" "36.9" "46.3" "46.8" "45.3" "54.3" "53.8" "46.1" "52.4" "" "" "" "" "" "" "" "" "" "" "47.6" "41.1" "23.3" "33.7" "38.4" "35.2" "41.8" "46.3" "35.9" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "12.108" "4" "3" "5" "3" "841" "92.8" "10.11" "13.30" "3" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "1.011" "1.096" "1.049" "0.927" "1.092" "1.169" "0.957" "1.017" "1.093" "83.7" "84.7" "91.7" "87.8" "77.6" "91.4" "97.9" "80.1" "85.1" "91.5" "" "" "" "" "" "" "" "" "" "" "83.7" "71.6" "58.0" "64.0" "63.6" "71.0" "75.5" "68.9" "66.4" "82.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "12.092" "37" "3" "7" "3" "86" "10.1" "6.52" "25.41" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.929" "0.922" "1.012" "1.041" "0.906" "0.962" "0.973" "0.986" "1.039" "237.7" "220.8" "219.1" "240.6" "247.5" "215.4" "228.7" "231.2" "234.2" "246.9" "" "" "" "" "" "" "" "" "" "" "237.7" "186.8" "138.5" "175.4" "202.8" "167.3" "176.3" "198.8" "182.8" "222.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "12.084" "9" "4" "5" "4" "365" "40.8" "6.04" "16.47" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "Nanoparticle triggered autophagic cell death" "" "1" "0" "1.123" "0.952" "1.061" "1.162" "1.017" "1.222" "1.109" "0.947" "1.028" "228.5" "256.6" "217.6" "242.4" "265.6" "232.5" "279.3" "253.4" "216.4" "234.9" "" "" "" "" "" "" "" "" "" "" "228.5" "217.1" "137.6" "176.7" "217.6" "180.6" "215.3" "217.9" "168.9" "211.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.000" "False" "12.076" "10" "4" "5" "4" "325" "36.9" "8.78" "13.69" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6212598245542673461" "False" "High" "IsMasterProtein" "Q92879" "CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2" "0.000" "False" "12.051" "8" "4" "4" "4" "486" "52.0" "8.46" "11.61" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10658" "ENSG00000149187" "CELF1" "B4E2U5; D3DQS0; F8W940; Q4LE52; Q92879; Q9NP83; Q9NR06" "Adipogenesis; mRNA processing" "" "2" "0" "1.133" "0.890" "1.103" "0.999" "0.907" "0.927" "0.891" "0.898" "0.898" "183.0" "207.3" "162.9" "201.7" "182.8" "166.0" "169.6" "163.0" "164.3" "164.4" "" "" "" "" "" "" "" "" "" "" "183.0" "175.3" "103.0" "147.1" "149.8" "128.9" "130.8" "140.2" "128.3" "147.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "12.033" "3" "4" "5" "4" "1581" "168.4" "8.73" "12.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "Cytoprotection by HMOX1; Estrogen-dependent gene expression; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "18" "0" "1.398" "1.320" "1.562" "1.223" "0.949" "1.262" "1.171" "1.142" "1.134" "40.0" "56.0" "52.8" "62.5" "49.0" "38.0" "50.5" "46.9" "45.7" "45.4" "" "" "" "" "" "" "" "" "" "" "40.0" "47.4" "33.4" "45.6" "40.1" "29.5" "38.9" "40.3" "35.7" "40.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "12.032" "8" "3" "3" "3" "423" "48.1" "8.59" "9.74" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.117" "1.072" "1.021" "1.083" "1.188" "1.052" "0.974" "1.110" "1.152" "103.8" "115.9" "111.2" "106.0" "112.3" "123.3" "109.2" "101.1" "115.2" "119.5" "" "" "" "" "" "" "" "" "" "" "103.8" "98.0" "70.3" "77.3" "92.0" "95.8" "84.1" "86.9" "89.9" "107.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "12.020" "11" "2" "3" "2" "188" "21.0" "5.14" "10.52" "2" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "" "Glutathione synthesis and recycling" "1" "0" "0.855" "0.920" "0.884" "0.865" "1.038" "0.850" "0.826" "1.047" "0.877" "151.5" "129.5" "139.5" "134.0" "131.1" "157.2" "128.8" "125.2" "158.7" "133.0" "" "" "" "" "" "" "" "" "" "" "151.5" "109.6" "88.2" "97.7" "107.4" "122.1" "99.3" "107.7" "123.9" "119.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "12.015" "14" "4" "6" "4" "308" "34.5" "5.12" "16.50" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.943" "0.914" "0.925" "0.930" "0.953" "1.057" "0.975" "0.865" "1.005" "173.9" "164.0" "158.9" "160.8" "161.7" "165.7" "183.8" "169.4" "150.4" "174.7" "" "" "" "" "" "" "" "" "" "" "173.9" "138.8" "100.4" "117.3" "132.5" "128.7" "141.7" "145.7" "117.4" "157.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047850882453787868" "False" "High" "IsMasterProtein" "Q96S19" "Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2" "0.000" "False" "12.013" "11" "2" "5" "2" "204" "22.6" "7.83" "14.45" "2" "" "" "other molecular function" "Pf06080" "84326" "ENSG00000130731" "METTL26" "A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53; hsa:84326; Q96IW1; Q96MD6; Q96S19" "" "" "0" "0" "0.956" "1.087" "1.016" "1.074" "1.101" "1.140" "0.928" "1.160" "0.989" "47.5" "45.4" "51.7" "48.3" "51.0" "52.3" "54.2" "44.1" "55.1" "47.0" "" "" "" "" "" "" "" "" "" "" "47.5" "38.4" "32.7" "35.2" "41.8" "40.6" "41.8" "37.9" "43.0" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "12.009" "4" "3" "4" "3" "737" "80.9" "5.83" "12.68" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "3" "0" "1.082" "0.789" "0.947" "1.005" "0.872" "1.000" "1.020" "0.811" "0.984" "307.7" "333.0" "242.9" "291.2" "309.3" "268.2" "307.5" "313.8" "249.4" "302.7" "" "" "" "" "" "" "" "" "" "" "307.7" "281.7" "153.6" "212.4" "253.4" "208.3" "237.1" "269.8" "194.7" "272.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "12.002" "14" "4" "4" "4" "291" "33.0" "9.66" "9.84" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA polymerase II transcribes snRNA genes" "10" "0" "1.056" "0.878" "1.028" "1.134" "1.153" "1.107" "1.006" "0.911" "1.018" "173.3" "182.9" "152.2" "178.2" "196.5" "199.8" "191.9" "174.4" "157.8" "176.5" "" "" "" "" "" "" "" "" "" "" "173.3" "154.8" "96.3" "130.0" "161.0" "155.2" "147.9" "150.0" "123.2" "158.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "11.991" "4" "1" "2" "1" "457" "49.6" "5.12" "9.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Oxidative damage response" "Regulation of HSF1-mediated heat shock response; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "5" "0" "1.021" "0.762" "1.221" "1.006" "1.099" "1.106" "0.852" "1.074" "1.034" "51.0" "52.0" "38.8" "62.2" "51.2" "56.0" "56.4" "43.4" "54.7" "52.7" "" "" "" "" "" "" "" "" "" "" "51.0" "44.0" "24.6" "45.4" "42.0" "43.5" "43.4" "37.3" "42.7" "47.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "11.990" "7" "4" "5" "4" "583" "65.8" "6.99" "11.50" "4" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "0.932" "0.880" "1.052" "0.920" "0.887" "1.037" "0.951" "0.973" "0.961" "170.4" "158.8" "150.0" "179.3" "156.8" "151.1" "176.7" "162.1" "165.9" "163.7" "" "" "" "" "" "" "" "" "" "" "170.4" "134.3" "94.8" "130.7" "128.5" "117.3" "136.2" "139.4" "129.5" "147.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740912979344048922" "False" "High" "IsMasterProtein" "Q99871" "HAUS augmin-like complex subunit 7 OS=Homo sapiens OX=9606 GN=HAUS7 PE=1 SV=4" "0.000" "False" "11.981" "4" "1" "2" "1" "358" "39.8" "4.75" "8.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "" "55559" "ENSG00000213397" "HAUS7" "B4DUH6; D3DWT9; Q96HS8; Q99871; Q9NP54; Q9UFH9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "0.892" "0.813" "1.116" "1.041" "0.867" "1.101" "1.148" "0.895" "0.889" "110.3" "98.5" "89.7" "123.1" "114.9" "95.7" "121.5" "126.6" "98.7" "98.0" "" "" "" "" "" "" "" "" "" "" "110.3" "83.3" "56.7" "89.8" "94.1" "74.3" "93.6" "108.9" "77.1" "88.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "11.976" "24" "4" "11" "1" "136" "15.3" "11.27" "33.63" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; Amyloid fiber formation; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "36" "3" "1.146" "1.262" "1.095" "1.230" "1.072" "1.202" "1.104" "1.079" "1.107" "206.8" "237.0" "260.9" "226.4" "254.4" "221.7" "248.5" "228.4" "223.1" "228.9" "" "" "" "" "" "" "" "" "" "" "206.8" "200.5" "165.0" "165.1" "208.4" "172.1" "191.6" "196.4" "174.2" "205.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "11.937" "12" "3" "4" "3" "250" "27.4" "8.60" "11.99" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Vitamin B12 metabolism" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "3" "0" "1.051" "0.914" "0.809" "1.075" "1.129" "0.888" "0.952" "0.945" "0.893" "58.0" "60.9" "53.0" "46.9" "62.4" "65.5" "51.5" "55.2" "54.8" "51.8" "" "" "" "" "" "" "" "" "" "" "58.0" "51.6" "33.5" "34.2" "51.1" "50.8" "39.7" "47.4" "42.8" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "11.929" "6" "4" "4" "4" "717" "79.9" "8.31" "11.94" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "" "tRNA modification in the mitochondrion" "1" "0" "1.137" "0.979" "1.134" "1.046" "0.881" "1.097" "0.946" "1.017" "0.962" "70.1" "79.8" "68.7" "79.6" "73.4" "61.8" "76.9" "66.3" "71.4" "67.5" "" "" "" "" "" "" "" "" "" "" "70.1" "67.5" "43.4" "58.0" "60.1" "48.0" "59.3" "57.0" "55.7" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "11.923" "11" "2" "4" "2" "219" "24.6" "4.83" "13.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Ferroptosis" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "3" "0" "0.995" "0.955" "1.168" "1.122" "1.055" "1.267" "1.104" "1.026" "1.120" "170.6" "169.7" "162.9" "199.3" "191.5" "179.9" "216.1" "188.4" "175.1" "191.1" "" "" "" "" "" "" "" "" "" "" "170.6" "143.5" "103.0" "145.3" "156.9" "139.7" "166.6" "162.0" "136.7" "171.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "11.920" "12" "3" "5" "3" "193" "20.8" "5.31" "15.41" "3" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism" "3" "0" "0.994" "1.064" "0.970" "1.055" "0.948" "1.078" "0.953" "0.968" "0.892" "367.8" "365.6" "391.4" "356.7" "388.1" "348.5" "396.4" "350.4" "356.0" "328.2" "" "" "" "" "" "" "" "" "" "" "367.8" "309.3" "247.5" "260.1" "317.9" "270.7" "305.5" "301.3" "277.9" "295.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "11.917" "12" "5" "7" "3" "344" "39.6" "11.43" "18.30" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "1" "1.156" "1.253" "0.944" "1.226" "1.418" "1.183" "1.346" "1.286" "1.302" "394.3" "455.9" "494.0" "372.1" "483.3" "559.2" "466.3" "530.7" "506.9" "513.4" "" "" "" "" "" "" "" "" "" "" "394.3" "385.7" "312.4" "271.3" "396.0" "434.3" "359.4" "456.3" "395.7" "461.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174498408520760419" "False" "High" "IsMasterProtein" "Q02241" "Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3" "0.000" "False" "11.915" "3" "2" "2" "2" "960" "110.0" "8.51" "9.14" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf16540" "9493" "ENSG00000137807" "KIF23" "B4E1K0; hsa:9493; Q02241; Q8WVP0" "Pleural mesothelioma" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis" "5" "0" "0.839" "0.563" "0.850" "1.041" "0.586" "0.942" "0.974" "0.491" "0.864" "152.4" "127.9" "85.9" "129.6" "158.8" "89.3" "143.6" "148.4" "74.8" "131.8" "" "" "" "" "" "" "" "" "" "" "152.4" "108.2" "54.3" "94.5" "130.1" "69.4" "110.7" "127.6" "58.4" "118.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5616367941086101468" "False" "High" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "0.000" "False" "11.910" "6" "4" "4" "4" "570" "65.0" "8.24" "11.87" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "" "Factors involved in megakaryocyte development and platelet production; Intra-Golgi traffic; SARS-CoV-2 modulates autophagy" "3" "0" "1.066" "1.051" "1.050" "0.983" "1.047" "0.966" "0.936" "1.051" "0.999" "187.7" "200.1" "197.3" "197.1" "184.6" "196.5" "181.3" "175.7" "197.3" "187.5" "" "" "" "" "" "" "" "" "" "" "187.7" "169.3" "124.8" "143.7" "151.2" "152.6" "139.8" "151.1" "154.0" "168.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "11.903" "4" "2" "3" "2" "505" "55.4" "4.88" "8.88" "2" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "High" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.000" "False" "11.890" "3" "2" "4" "2" "605" "70.1" "5.47" "11.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.878" "0.559" "1.114" "0.749" "0.983" "0.759" "0.930" "0.750" "0.717" "21.2" "18.6" "11.8" "23.6" "15.9" "20.8" "16.1" "19.7" "15.9" "15.2" "" "" "" "" "" "" "" "" "" "" "21.2" "15.7" "7.5" "17.2" "13.0" "16.2" "12.4" "16.9" "12.4" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "11.886" "9" "4" "5" "4" "434" "48.3" "7.93" "15.70" "4" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialylation" "Sialic acid metabolism" "2" "0" "1.092" "0.870" "0.978" "0.963" "0.958" "0.840" "1.013" "0.933" "0.832" "129.0" "140.8" "112.2" "126.1" "124.2" "123.5" "108.3" "130.7" "120.3" "107.3" "" "" "" "" "" "" "" "" "" "" "129.0" "119.1" "70.9" "91.9" "101.8" "95.9" "83.5" "112.4" "93.9" "96.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.000" "False" "11.880" "10" "2" "2" "2" "329" "36.6" "6.10" "10.42" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "Serotonin transporter activity; Monoamine transport" "" "2" "0" "1.045" "0.638" "0.850" "1.011" "0.847" "0.862" "1.041" "0.967" "0.784" "45.1" "47.2" "28.8" "38.4" "45.6" "38.2" "38.9" "47.0" "43.6" "35.4" "" "" "" "" "" "" "" "" "" "" "45.1" "39.9" "18.2" "28.0" "37.4" "29.7" "30.0" "40.4" "34.1" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945924760519134314" "False" "High" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "0.000" "False" "11.869" "5" "2" "2" "2" "493" "57.0" "7.40" "9.65" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "0.946" "0.791" "1.102" "1.023" "0.964" "1.062" "0.918" "0.907" "0.931" "150.3" "142.2" "118.9" "165.6" "153.8" "144.9" "159.6" "138.0" "136.3" "140.0" "" "" "" "" "" "" "" "" "" "" "150.3" "120.3" "75.2" "120.8" "126.0" "112.5" "123.0" "118.7" "106.4" "125.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4931677639378713516" "False" "High" "IsMasterProtein" "A6NFQ2" "TRPM8 channel-associated factor 2 OS=Homo sapiens OX=9606 GN=TCAF2 PE=1 SV=2" "0.000" "False" "11.867" "4" "3" "4" "3" "919" "100.8" "7.17" "10.59" "3" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf13402, Pf17291" "285966" "ENSG00000170379" "TCAF2" "A6NFQ2; B4DK02; hsa:285966; Q14D25; Q17RQ4; Q8IWQ0; Q8NF84" "" "" "0" "0" "1.322" "1.359" "1.283" "1.128" "1.270" "1.061" "1.047" "1.435" "1.152" "286.6" "379.0" "389.6" "367.7" "323.4" "363.9" "304.1" "300.2" "411.4" "330.1" "" "" "" "" "" "" "" "" "" "" "286.6" "320.7" "246.4" "268.1" "265.0" "282.6" "234.4" "258.1" "321.2" "296.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "11.863" "9" "2" "3" "2" "261" "28.1" "5.91" "10.23" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "1.165" "0.952" "1.020" "1.040" "0.892" "0.919" "1.077" "1.031" "1.135" "83.6" "97.5" "79.6" "85.3" "86.9" "74.6" "76.9" "90.1" "86.3" "94.9" "" "" "" "" "" "" "" "" "" "" "83.6" "82.5" "50.3" "62.2" "71.2" "57.9" "59.3" "77.4" "67.3" "85.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "11.857" "11" "2" "4" "2" "273" "29.3" "8.18" "11.27" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "" "Ion transport by P-type ATPases" "1" "0" "1.022" "1.040" "1.008" "0.981" "1.036" "1.142" "1.056" "0.987" "1.065" "146.2" "149.4" "152.0" "147.3" "143.4" "151.4" "167.0" "154.3" "144.2" "155.6" "" "" "" "" "" "" "" "" "" "" "146.2" "126.4" "96.1" "107.4" "117.5" "117.6" "128.7" "132.7" "112.6" "139.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "11.856" "8" "3" "3" "3" "436" "49.2" "8.81" "10.40" "3" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "23" "0" "0.915" "1.001" "1.037" "1.021" "1.003" "1.044" "0.958" "1.012" "1.123" "94.9" "86.8" "94.9" "98.3" "96.8" "95.2" "99.1" "90.9" "96.0" "106.6" "" "" "" "" "" "" "" "" "" "" "94.9" "73.5" "60.0" "71.7" "79.3" "73.9" "76.4" "78.1" "74.9" "95.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "High" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.000" "False" "11.834" "18" "2" "4" "2" "119" "13.4" "5.52" "14.22" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.085" "0.940" "0.990" "1.098" "1.113" "1.309" "1.095" "1.052" "1.143" "59.2" "64.2" "55.6" "58.5" "64.9" "65.8" "77.4" "64.8" "62.2" "67.6" "" "" "" "" "" "" "" "" "" "" "59.2" "54.3" "35.1" "42.7" "53.2" "51.1" "59.7" "55.7" "48.6" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "11.818" "7" "3" "3" "3" "723" "78.3" "5.58" "8.27" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "3" "0" "1.129" "1.040" "1.421" "1.442" "1.134" "1.504" "1.196" "0.928" "1.052" "56.8" "64.2" "59.1" "80.8" "82.0" "64.5" "85.5" "68.0" "52.8" "59.8" "" "" "" "" "" "" "" "" "" "" "56.8" "54.3" "37.4" "58.9" "67.2" "50.1" "65.9" "58.5" "41.2" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7751322844419777287" "False" "High" "IsMasterProtein" "P33121" "Long-chain-fatty-acid--CoA ligase 1 OS=Homo sapiens OX=9606 GN=ACSL1 PE=1 SV=1" "0.000" "False" "11.818" "6" "4" "4" "4" "698" "77.9" "7.15" "9.88" "4" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00501" "2180" "ENSG00000151726" "ACSL1" "B7Z452; D3DP57; hsa:2180; P33121; P41215; Q8N8V7; Q8TA99" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders; Fatty acids and lipoproteins transport in hepatocytes; Cholesterol biosynthesis pathway in hepatocytes" "PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism" "17" "0" "1.186" "1.008" "1.138" "1.143" "1.083" "1.066" "1.252" "0.910" "1.060" "68.4" "81.1" "69.0" "77.8" "78.2" "74.1" "72.9" "85.6" "62.2" "72.5" "" "" "" "" "" "" "" "" "" "" "68.4" "68.6" "43.6" "56.8" "64.0" "57.5" "56.2" "73.6" "48.6" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.000" "False" "11.813" "12" "4" "4" "4" "334" "38.4" "6.04" "11.39" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "1.070" "1.098" "1.157" "1.157" "1.098" "1.178" "1.104" "1.046" "1.102" "90.3" "96.6" "99.1" "104.5" "104.5" "99.1" "106.4" "99.7" "94.5" "99.5" "" "" "" "" "" "" "" "" "" "" "90.3" "81.8" "62.7" "76.2" "85.6" "77.0" "82.0" "85.7" "73.8" "89.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "11.806" "3" "2" "3" "2" "1103" "122.0" "5.06" "12.25" "2" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "1.095" "1.204" "1.095" "1.065" "1.111" "1.073" "0.992" "1.013" "1.081" "129.6" "142.0" "156.0" "142.0" "138.1" "144.0" "139.1" "128.6" "131.4" "140.1" "" "" "" "" "" "" "" "" "" "" "129.6" "120.1" "98.7" "103.5" "113.1" "111.8" "107.3" "110.6" "102.6" "126.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "11.804" "4" "2" "3" "2" "490" "54.9" "10.13" "8.20" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.106" "1.020" "0.940" "1.099" "1.145" "1.028" "0.951" "1.105" "1.079" "87.2" "96.5" "89.0" "81.9" "95.9" "99.8" "89.6" "82.9" "96.4" "94.1" "" "" "" "" "" "" "" "" "" "" "87.2" "81.6" "56.3" "59.7" "78.5" "77.5" "69.1" "71.2" "75.2" "84.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519156847082484659" "False" "High" "IsMasterProtein" "Q16695" "Histone H3.1t OS=Homo sapiens OX=9606 GN=H3-4 PE=1 SV=3" "0.000" "False" "11.800" "24" "4" "10" "1" "136" "15.5" "11.12" "30.64" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8290" "ENSG00000168148; ENSG00000285435" "H3-4" "B2R5K3; hsa:8290; Q16695; Q6FGU4" "Follicle stimulating hormone (FSH) signaling pathway; Male infertility" "Meiotic synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ)" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.000" "False" "11.797" "20" "4" "4" "4" "196" "22.2" "10.33" "12.57" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.055" "1.221" "1.131" "1.173" "1.083" "1.184" "1.102" "1.178" "1.223" "185.5" "195.7" "226.5" "209.8" "217.7" "200.9" "219.7" "204.4" "218.6" "226.9" "" "" "" "" "" "" "" "" "" "" "185.5" "165.5" "143.2" "153.0" "178.3" "156.0" "169.3" "175.7" "170.7" "204.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.000" "False" "11.789" "16" "2" "3" "2" "194" "20.6" "10.81" "11.25" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.138" "1.017" "1.069" "1.017" "0.971" "1.052" "1.021" "0.996" "1.138" "122.7" "139.6" "124.8" "131.2" "124.8" "119.2" "129.1" "125.3" "122.2" "139.6" "" "" "" "" "" "" "" "" "" "" "122.7" "118.1" "78.9" "95.7" "102.3" "92.5" "99.5" "107.8" "95.4" "125.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "11.782" "6" "3" "3" "3" "577" "63.1" "9.44" "11.11" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.958" "0.987" "0.918" "1.042" "1.260" "1.130" "1.198" "1.044" "0.945" "140.5" "134.7" "138.8" "129.0" "146.4" "177.1" "158.8" "168.4" "146.7" "132.9" "" "" "" "" "" "" "" "" "" "" "140.5" "114.0" "87.7" "94.1" "120.0" "137.5" "122.4" "144.8" "114.5" "119.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "11.775" "6" "3" "4" "3" "428" "48.8" "5.16" "11.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "31" "0" "0.934" "0.930" "1.000" "0.946" "0.994" "0.944" "1.056" "0.886" "0.939" "262.8" "245.5" "244.5" "262.8" "248.5" "261.1" "248.0" "277.6" "232.8" "246.9" "" "" "" "" "" "" "" "" "" "" "262.8" "207.7" "154.6" "191.6" "203.6" "202.8" "191.2" "238.7" "181.7" "222.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165115417245555276" "False" "High" "IsMasterProtein" "Q15293" "Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1" "0.000" "False" "11.771" "10" "4" "8" "4" "331" "38.9" "5.00" "25.86" "4" "developmental processes" "ER/Golgi" "other molecular function" "Pf13202" "5954" "ENSG00000049449" "RCN1" "B7Z1M1; D3DR00; hsa:5954; Q15293" "VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "0.929" "0.994" "0.992" "1.014" "0.947" "1.156" "0.884" "0.974" "1.025" "403.6" "374.9" "401.3" "400.2" "409.1" "382.1" "466.6" "356.7" "393.3" "413.6" "" "" "" "" "" "" "" "" "" "" "403.6" "317.2" "253.8" "291.8" "335.1" "296.7" "359.7" "306.7" "307.0" "371.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "11.766" "3" "5" "5" "5" "1717" "190.2" "6.06" "13.64" "5" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "1.066" "0.953" "0.992" "1.312" "0.921" "1.022" "0.878" "1.054" "0.927" "149.5" "159.3" "142.5" "148.3" "196.1" "137.8" "152.7" "131.2" "157.6" "138.6" "" "" "" "" "" "" "" "" "" "" "149.5" "134.8" "90.1" "108.2" "160.7" "107.0" "117.7" "112.8" "123.0" "124.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "11.762" "5" "2" "3" "2" "454" "51.4" "8.19" "9.54" "2" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan metabolism" "Tryptophan catabolism" "2" "0" "1.442" "1.250" "1.215" "0.984" "1.247" "1.188" "1.484" "0.643" "1.033" "27.6" "39.8" "34.5" "33.6" "27.2" "34.4" "32.8" "41.0" "17.8" "28.5" "" "" "" "" "" "" "" "" "" "" "27.6" "33.7" "21.8" "24.5" "22.3" "26.8" "25.3" "35.2" "13.9" "25.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "11.748" "10" "3" "5" "3" "395" "45.3" "9.29" "10.42" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.949" "1.003" "0.955" "0.906" "1.014" "1.135" "1.051" "0.998" "1.037" "236.4" "224.2" "237.0" "225.6" "214.2" "239.6" "268.2" "248.5" "236.0" "245.1" "" "" "" "" "" "" "" "" "" "" "236.4" "189.7" "149.9" "164.5" "175.5" "186.1" "206.8" "213.6" "184.2" "220.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "11.728" "2" "3" "3" "3" "1135" "128.1" "7.83" "9.76" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.055" "1.364" "1.141" "1.130" "1.457" "1.073" "1.023" "1.281" "1.247" "196.0" "206.7" "267.2" "223.6" "221.5" "285.6" "210.3" "200.5" "251.0" "244.3" "" "" "" "" "" "" "" "" "" "" "196.0" "174.9" "169.0" "163.0" "181.5" "221.8" "162.1" "172.4" "195.9" "219.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "11.720" "7" "3" "4" "3" "393" "44.9" "8.63" "12.10" "3" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "" "Platelet degranulation" "1" "0" "1.164" "0.903" "0.905" "1.270" "1.100" "1.169" "1.235" "1.185" "1.038" "24.8" "28.8" "22.4" "22.4" "31.5" "27.3" "29.0" "30.6" "29.4" "25.7" "" "" "" "" "" "" "" "" "" "" "24.8" "24.4" "14.1" "16.3" "25.8" "21.2" "22.3" "26.3" "22.9" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144980634344963458" "False" "High" "IsMasterProtein" "O14686" "Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2" "0.000" "False" "11.705" "1" "3" "3" "3" "5537" "593.0" "5.58" "6.55" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "8085" "ENSG00000167548" "KMT2D" "hsa:8085; O14686; O14687" "Histone modifications; 16p11.2 proximal deletion syndrome" "Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "0.975" "0.855" "1.062" "1.023" "0.928" "1.005" "1.018" "0.795" "0.850" "64.8" "63.2" "55.4" "68.8" "66.3" "60.1" "65.1" "65.9" "51.5" "55.1" "" "" "" "" "" "" "" "" "" "" "64.8" "53.4" "35.0" "50.2" "54.3" "46.7" "50.2" "56.7" "40.2" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2382558777454412534" "False" "High" "IsMasterProtein" "P25686" "DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3" "0.000" "False" "11.699" "10" "3" "3" "3" "324" "35.6" "5.95" "9.40" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00226" "3300" "ENSG00000135924" "DNAJB2" "A8K9P6; hsa:3300; P25686; Q53QD7; Q8IUK1; Q8IUK2; Q96F52" "" "" "0" "0" "1.035" "0.763" "1.014" "1.021" "0.894" "1.087" "0.994" "0.785" "0.962" "180.3" "186.6" "137.6" "182.7" "184.0" "161.1" "196.0" "179.1" "141.5" "173.4" "" "" "" "" "" "" "" "" "" "" "180.3" "157.9" "87.0" "133.2" "150.7" "125.1" "151.1" "154.0" "110.5" "155.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "11.686" "13" "3" "3" "3" "254" "29.0" "5.50" "11.53" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "1.082" "0.938" "1.073" "1.172" "1.081" "1.125" "1.090" "0.961" "1.107" "269.6" "291.6" "252.9" "289.1" "316.0" "291.3" "303.3" "293.8" "259.1" "298.3" "" "" "" "" "" "" "" "" "" "" "269.6" "246.7" "159.9" "210.8" "258.9" "226.3" "233.8" "252.6" "202.2" "268.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "11.686" "8" "4" "5" "4" "451" "49.7" "6.05" "16.67" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.922" "0.835" "0.974" "0.980" "0.798" "0.932" "0.955" "0.738" "0.910" "482.3" "444.4" "402.5" "469.8" "472.5" "385.0" "449.7" "460.6" "355.8" "438.7" "" "" "" "" "" "" "" "" "" "" "482.3" "376.0" "254.5" "342.5" "387.1" "299.0" "346.6" "396.0" "277.8" "394.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695950193153579401" "False" "High" "IsMasterProtein" "Q6VEQ5" "WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2" "0.000" "False" "11.682" "8" "3" "4" "1" "465" "50.3" "5.71" "11.70" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH2P" "Q6VEQ5" "" "" "0" "1" "0.954" "1.176" "1.280" "1.159" "1.109" "1.244" "1.135" "1.133" "1.345" "31.1" "29.7" "36.6" "39.9" "36.1" "34.5" "38.7" "35.4" "35.3" "41.9" "" "" "" "" "" "" "" "" "" "" "31.1" "25.1" "23.2" "29.1" "29.6" "26.8" "29.9" "30.4" "27.5" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3006741669515463279" "False" "High" "IsMasterProtein" "Q8WUD1" "Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1" "0.000" "False" "11.681" "10" "2" "3" "2" "216" "24.2" "7.83" "9.67" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "84932" "ENSG00000129472" "RAB2B" "B2RD03; D3DS24; hsa:84932; Q6NZ33; Q8WUD1" "" "RAB geranylgeranylation" "1" "0" "1.042" "1.170" "1.065" "1.130" "1.351" "1.159" "1.121" "1.191" "1.072" "87.2" "90.8" "102.0" "92.8" "98.5" "117.8" "101.0" "97.8" "103.8" "93.5" "" "" "" "" "" "" "" "" "" "" "87.2" "76.8" "64.5" "67.7" "80.7" "91.5" "77.9" "84.1" "81.0" "84.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7498907094133803237" "False" "High" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "0.000" "False" "11.679" "4" "3" "4" "3" "747" "83.3" "6.58" "11.56" "3" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400, Pf12894" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "" "CDC42 GTPase cycle" "1" "0" "1.024" "0.945" "0.968" "0.962" "0.864" "0.956" "0.956" "0.826" "1.004" "144.8" "148.3" "136.9" "140.2" "139.3" "125.1" "138.5" "138.4" "119.6" "145.4" "" "" "" "" "" "" "" "" "" "" "144.8" "125.5" "86.5" "102.2" "114.1" "97.2" "106.7" "119.0" "93.3" "130.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "11.678" "7" "4" "4" "4" "520" "60.7" "6.77" "12.47" "4" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "1.058" "1.150" "1.026" "1.102" "1.160" "0.990" "1.198" "1.123" "1.098" "65.1" "68.9" "74.9" "66.8" "71.8" "75.5" "64.4" "78.0" "73.2" "71.5" "" "" "" "" "" "" "" "" "" "" "65.1" "58.3" "47.4" "48.7" "58.8" "58.6" "49.7" "67.1" "57.1" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "High" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.000" "False" "11.660" "21" "3" "4" "3" "110" "12.5" "11.06" "12.93" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.871" "1.516" "1.017" "1.085" "1.505" "1.008" "1.441" "1.607" "1.208" "336.6" "293.1" "510.3" "342.3" "365.4" "506.8" "339.3" "485.2" "540.9" "406.7" "" "" "" "" "" "" "" "" "" "" "336.6" "248.0" "322.7" "249.6" "299.4" "393.5" "261.6" "417.2" "422.2" "365.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2653046833350144460" "False" "High" "IsMasterProtein" "Q96JZ2" "Hematopoietic SH2 domain-containing protein OS=Homo sapiens OX=9606 GN=HSH2D PE=1 SV=1" "0.000" "False" "11.660" "11" "3" "4" "3" "352" "39.0" "7.11" "7.94" "3" "signal transduction" "nucleus;other cell component" "" "Pf00017" "84941" "ENSG00000196684" "HSH2D" "B5ME72; hsa:84941; Q6ZNG7; Q96JZ2" "" "" "0" "0" "1.051" "0.620" "0.982" "1.242" "0.770" "0.977" "1.089" "0.719" "0.910" "122.1" "128.3" "75.7" "120.0" "151.7" "94.1" "119.3" "132.9" "87.8" "111.1" "" "" "" "" "" "" "" "" "" "" "122.1" "108.6" "47.9" "87.5" "124.3" "73.1" "92.0" "114.3" "68.5" "99.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "11.657" "9" "2" "2" "2" "258" "29.0" "5.81" "7.88" "2" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Ciliary landscape; 22q11.2 copy number variation syndrome" "Intra-Golgi traffic; Neutrophil degranulation" "4" "0" "1.034" "0.669" "1.090" "1.056" "0.866" "1.071" "1.051" "0.723" "0.886" "103.2" "106.7" "69.0" "112.5" "108.9" "89.3" "110.5" "108.5" "74.6" "91.4" "" "" "" "" "" "" "" "" "" "" "103.2" "90.3" "43.7" "82.0" "89.3" "69.4" "85.2" "93.3" "58.2" "82.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "11.646" "5" "4" "5" "4" "730" "79.4" "8.87" "15.44" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "2" "0" "1.212" "1.202" "1.176" "0.985" "1.319" "1.007" "0.972" "1.277" "1.106" "199.4" "241.6" "239.7" "234.6" "196.4" "263.1" "200.8" "193.9" "254.7" "220.5" "" "" "" "" "" "" "" "" "" "" "199.4" "204.4" "151.6" "171.1" "160.9" "204.3" "154.8" "166.7" "198.8" "198.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "11.639" "24" "2" "3" "2" "93" "10.4" "4.93" "10.26" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.197" "0.882" "1.086" "1.424" "1.458" "1.221" "1.137" "1.308" "1.202" "34.7" "41.5" "30.6" "37.7" "49.4" "50.6" "42.4" "39.4" "45.4" "41.7" "" "" "" "" "" "" "" "" "" "" "34.7" "35.1" "19.4" "27.5" "40.5" "39.3" "32.7" "33.9" "35.4" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7507804791058133428" "False" "High" "IsMasterProtein" "Q9NX74" "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS2 PE=1 SV=1" "0.000" "False" "11.637" "7" "3" "3" "3" "493" "55.0" "7.11" "9.33" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf01207" "54920" "ENSG00000167264" "DUS2" "A8K3G3; hsa:54920; Q4H4D9; Q9NX74" "" "PKR-mediated signaling; tRNA modification in the nucleus and cytosol" "2" "0" "1.043" "0.810" "1.093" "1.046" "0.855" "1.087" "1.115" "0.975" "0.945" "206.8" "215.8" "167.6" "226.1" "216.4" "176.7" "224.8" "230.6" "201.5" "195.4" "" "" "" "" "" "" "" "" "" "" "206.8" "182.5" "106.0" "164.9" "177.3" "137.3" "173.3" "198.2" "157.3" "175.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "11.637" "6" "4" "4" "4" "796" "86.6" "5.69" "11.64" "4" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "0.980" "0.999" "1.025" "1.053" "1.071" "1.017" "0.965" "1.016" "1.056" "275.8" "270.3" "275.7" "282.6" "290.4" "295.5" "280.4" "266.2" "280.2" "291.2" "" "" "" "" "" "" "" "" "" "" "275.8" "228.6" "174.3" "206.1" "237.9" "229.5" "216.2" "228.9" "218.7" "261.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.000" "False" "11.631" "16" "3" "3" "2" "195" "21.3" "6.89" "9.84" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7386528410140377558" "False" "High" "IsMasterProtein" "Q9H147" "Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens OX=9606 GN=DNTTIP1 PE=1 SV=2" "0.000" "False" "11.630" "8" "2" "2" "2" "329" "37.0" "8.97" "10.39" "2" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18192, Pf21229" "116092" "ENSG00000101457" "DNTTIP1" "B2RA18; hsa:116092; Q96DE3; Q9BQP2; Q9H147; Q9H148" "" "" "0" "0" "1.030" "0.991" "1.091" "1.171" "1.043" "1.182" "1.135" "0.902" "1.074" "206.4" "212.6" "204.6" "225.1" "241.7" "215.2" "243.9" "234.3" "186.2" "221.7" "" "" "" "" "" "" "" "" "" "" "206.4" "179.9" "129.4" "164.1" "198.0" "167.1" "188.0" "201.4" "145.3" "199.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "11.620" "23" "2" "2" "2" "107" "12.4" "6.77" "7.99" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Dual Incision in GG-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "25" "0" "1.177" "0.928" "1.335" "1.101" "1.024" "1.173" "1.157" "0.985" "1.215" "94.2" "110.8" "87.4" "125.7" "103.7" "96.4" "110.4" "109.0" "92.7" "114.4" "" "" "" "" "" "" "" "" "" "" "94.2" "93.8" "55.3" "91.7" "85.0" "74.9" "85.1" "93.7" "72.4" "102.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "11.600" "15" "3" "4" "3" "197" "21.7" "6.55" "14.07" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "2" "0" "1.044" "1.068" "1.311" "1.222" "1.055" "1.120" "1.112" "1.116" "1.096" "121.0" "126.3" "129.3" "158.6" "148.0" "127.8" "135.6" "134.6" "135.1" "132.6" "" "" "" "" "" "" "" "" "" "" "121.0" "106.9" "81.8" "115.7" "121.2" "99.2" "104.5" "115.7" "105.5" "119.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "11.582" "8" "3" "3" "3" "432" "47.4" "6.70" "10.84" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.086" "0.801" "1.064" "1.065" "0.796" "1.147" "1.031" "0.818" "0.919" "168.5" "182.9" "135.0" "179.2" "179.4" "134.1" "193.2" "173.7" "137.8" "154.8" "" "" "" "" "" "" "" "" "" "" "168.5" "154.7" "85.3" "130.6" "147.0" "104.1" "149.0" "149.3" "107.5" "139.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "11.577" "12" "2" "3" "2" "175" "20.1" "8.95" "8.97" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "10" "0" "1.005" "0.832" "0.941" "0.789" "0.784" "0.875" "0.922" "0.905" "0.872" "127.8" "128.5" "106.4" "120.3" "100.9" "100.2" "111.8" "117.8" "115.7" "111.5" "" "" "" "" "" "" "" "" "" "" "127.8" "108.7" "67.3" "87.7" "82.6" "77.8" "86.2" "101.3" "90.3" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "11.576" "8" "3" "3" "3" "299" "32.8" "4.34" "10.67" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "TAR syndrome" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "3" "0" "0.937" "0.862" "0.904" "1.031" "0.883" "1.118" "0.934" "0.894" "0.886" "172.5" "161.6" "148.6" "155.9" "177.8" "152.3" "192.9" "161.2" "154.2" "152.9" "" "" "" "" "" "" "" "" "" "" "172.5" "136.7" "94.0" "113.7" "145.7" "118.3" "148.7" "138.6" "120.4" "137.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "11.563" "2" "3" "3" "3" "1164" "129.7" "6.47" "10.55" "3" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "27" "0" "1.157" "0.878" "1.121" "1.171" "0.913" "1.180" "1.074" "0.938" "1.056" "384.5" "444.9" "337.8" "431.0" "450.2" "351.0" "453.9" "413.2" "360.9" "406.2" "" "" "" "" "" "" "" "" "" "" "384.5" "376.4" "213.6" "314.3" "368.9" "272.6" "349.9" "355.2" "281.7" "365.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "11.558" "7" "2" "2" "2" "370" "43.1" "8.95" "7.71" "2" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "2q11.2 copy number variation syndrome" "Mitochondrial protein degradation; Synthesis of PC" "3" "0" "0.966" "1.006" "0.942" "0.967" "0.921" "1.171" "0.996" "1.237" "0.994" "34.1" "33.0" "34.3" "32.2" "33.0" "31.4" "40.0" "34.0" "42.2" "33.9" "" "" "" "" "" "" "" "" "" "" "34.1" "27.9" "21.7" "23.4" "27.0" "24.4" "30.8" "29.2" "32.9" "30.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "11.556" "2" "3" "3" "3" "1868" "208.3" "6.90" "8.12" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "2" "0" "1.095" "0.920" "1.083" "1.105" "0.967" "1.158" "1.035" "1.011" "1.021" "147.6" "161.6" "135.7" "159.8" "163.1" "142.7" "170.9" "152.7" "149.2" "150.7" "" "" "" "" "" "" "" "" "" "" "147.6" "136.7" "85.8" "116.5" "133.6" "110.8" "131.7" "131.3" "116.4" "135.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157641750499335080" "False" "High" "IsMasterProtein" "Q9C0C7" "Activating molecule in BECN1-regulated autophagy protein 1 OS=Homo sapiens OX=9606 GN=AMBRA1 PE=1 SV=2" "0.000" "False" "11.535" "4" "4" "5" "4" "1298" "142.4" "7.18" "14.60" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "55626" "ENSG00000110497" "AMBRA1" "A6XN33; D3DQP8; G3V193; hsa:55626; Q86XD6; Q9C0C7; Q9H8Z0; Q9NXE7" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism" "Macroautophagy" "6" "0" "0.875" "0.683" "0.947" "0.931" "0.811" "0.923" "0.946" "0.759" "0.895" "186.1" "162.8" "127.0" "176.1" "173.3" "150.8" "171.8" "176.0" "141.1" "166.5" "" "" "" "" "" "" "" "" "" "" "186.1" "137.7" "80.3" "128.4" "142.0" "117.1" "132.4" "151.3" "110.2" "149.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "11.532" "4" "1" "2" "1" "312" "33.2" "5.43" "8.63" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "0.942" "0.978" "0.962" "1.017" "0.989" "0.900" "0.965" "1.018" "0.939" "249.0" "234.5" "243.5" "239.7" "253.3" "246.2" "224.1" "240.4" "253.6" "233.9" "" "" "" "" "" "" "" "" "" "" "249.0" "198.4" "154.0" "174.7" "207.5" "191.2" "172.7" "206.7" "197.9" "210.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "11.514" "2" "3" "3" "3" "1576" "171.4" "8.09" "8.50" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508649530452010436" "False" "High" "IsMasterProtein" "P00167" "Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2" "0.000" "False" "11.504" "16" "1" "1" "1" "134" "15.3" "4.96" "6.68" "1" "transport" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00173" "1528" "ENSG00000166347" "CYB5A" "A8MV91; F8WEU4; hsa:1528; P00167; Q6IB14" "Oxidation by cytochrome P450" "Vitamin C (ascorbate) metabolism" "2" "0" "0.775" "1.238" "0.696" "0.913" "1.402" "1.094" "0.877" "1.331" "0.958" "26.8" "20.7" "33.2" "18.6" "24.4" "37.6" "29.3" "23.5" "35.6" "25.6" "" "" "" "" "" "" "" "" "" "" "26.8" "17.6" "21.0" "13.6" "20.0" "29.2" "22.6" "20.2" "27.8" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "11.495" "5" "1" "2" "1" "238" "26.7" "7.24" "7.55" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "11.492" "8" "3" "3" "3" "386" "43.5" "8.19" "10.81" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.071" "1.064" "0.867" "1.118" "1.016" "0.967" "0.982" "1.063" "0.911" "205.4" "220.0" "218.5" "178.0" "229.6" "208.6" "198.6" "201.8" "218.3" "187.1" "" "" "" "" "" "" "" "" "" "" "205.4" "186.2" "138.2" "129.8" "188.1" "162.0" "153.1" "173.5" "170.4" "168.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.000" "False" "11.474" "2" "2" "2" "2" "1186" "133.0" "5.22" "8.05" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "7" "0" "1.043" "0.866" "1.162" "1.103" "1.023" "1.021" "1.032" "1.024" "0.888" "131.0" "136.6" "113.4" "152.2" "144.6" "134.0" "133.7" "135.2" "134.1" "116.3" "" "" "" "" "" "" "" "" "" "" "131.0" "115.6" "71.7" "111.0" "118.4" "104.0" "103.1" "116.3" "104.7" "104.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "11.474" "10" "3" "4" "3" "476" "52.5" "7.56" "13.61" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.210" "0.968" "1.259" "1.226" "0.965" "1.086" "1.066" "1.045" "1.241" "16.7" "20.2" "16.2" "21.0" "20.5" "16.1" "18.1" "17.8" "17.4" "20.7" "" "" "" "" "" "" "" "" "" "" "16.7" "17.1" "10.2" "15.3" "16.8" "12.5" "14.0" "15.3" "13.6" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "11.465" "31" "5" "9" "5" "130" "14.8" "10.13" "21.43" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.944" "1.141" "1.072" "1.026" "1.184" "1.164" "1.150" "1.126" "1.007" "598.5" "565.3" "682.8" "641.6" "614.0" "708.5" "696.7" "688.4" "673.8" "602.7" "" "" "" "" "" "" "" "" "" "" "598.5" "478.2" "431.8" "467.9" "503.0" "550.2" "537.0" "591.9" "525.9" "541.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "11.453" "20" "3" "8" "1" "128" "13.5" "10.58" "24.59" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence" "35" "0" "1.163" "1.146" "1.014" "1.168" "1.182" "1.099" "1.094" "1.085" "1.096" "377.1" "438.5" "432.3" "382.6" "440.6" "445.8" "414.6" "412.7" "409.2" "413.4" "" "" "" "" "" "" "" "" "" "" "377.1" "370.9" "273.4" "279.0" "361.0" "346.2" "319.6" "354.8" "319.4" "371.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "11.451" "4" "3" "3" "3" "765" "86.5" "5.29" "10.43" "3" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "1.269" "1.094" "1.184" "1.321" "1.059" "1.166" "1.239" "0.939" "1.189" "203.0" "257.7" "222.1" "240.3" "268.1" "215.0" "236.7" "251.6" "190.6" "241.3" "" "" "" "" "" "" "" "" "" "" "203.0" "218.0" "140.4" "175.2" "219.7" "167.0" "182.5" "216.3" "148.8" "216.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "11.444" "7" "3" "6" "3" "540" "56.5" "5.52" "16.94" "3" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; PKR-mediated signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases" "24" "0" "1.141" "1.425" "1.278" "1.011" "1.279" "1.134" "1.131" "1.448" "1.040" "144.9" "165.3" "206.5" "185.1" "146.5" "185.3" "164.3" "163.9" "209.8" "150.7" "" "" "" "" "" "" "" "" "" "" "144.9" "139.9" "130.6" "135.0" "120.0" "143.9" "126.7" "140.9" "163.8" "135.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7259467159663286133" "False" "High" "IsMasterProtein" "Q9Y5N6" "Origin recognition complex subunit 6 OS=Homo sapiens OX=9606 GN=ORC6 PE=1 SV=1" "0.000" "False" "11.443" "12" "3" "5" "3" "252" "28.1" "8.66" "14.94" "3" "DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05460" "23594" "ENSG00000091651" "ORC6" "B3KN89; hsa:23594; Q9Y5N6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "0.987" "0.681" "0.988" "0.980" "0.729" "1.006" "1.001" "0.758" "0.888" "621.9" "613.5" "423.6" "614.3" "609.2" "453.2" "625.8" "622.6" "471.2" "552.1" "" "" "" "" "" "" "" "" "" "" "621.9" "519.1" "267.9" "447.9" "499.2" "352.0" "482.4" "535.3" "367.8" "496.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "11.435" "7" "3" "4" "3" "417" "46.9" "4.54" "15.48" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "0.985" "0.938" "0.932" "1.022" "0.909" "0.995" "1.047" "0.974" "0.896" "206.0" "202.8" "193.1" "192.0" "210.6" "187.2" "205.0" "215.8" "200.7" "184.5" "" "" "" "" "" "" "" "" "" "" "206.0" "171.6" "122.1" "140.0" "172.6" "145.4" "158.0" "185.5" "156.7" "165.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372150383973337968" "False" "High" "IsMasterProtein" "Q96AY4" "Tetratricopeptide repeat protein 28 OS=Homo sapiens OX=9606 GN=TTC28 PE=1 SV=4" "0.000" "False" "11.434" "2" "5" "6" "5" "2481" "270.7" "6.89" "15.27" "5" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf12770, Pf13176, Pf13424" "23331" "ENSG00000100154" "TTC28" "hsa:23331; K7ZRV2; O95928; O95929; Q5W189; Q96AY4; Q9NTE4; Q9UG31; Q9UGG5; Q9UPV8; Q9Y3S5" "" "" "0" "0" "0.991" "0.749" "0.956" "1.037" "0.781" "0.959" "0.961" "0.798" "0.969" "107.3" "106.3" "80.4" "102.6" "111.3" "83.8" "102.9" "103.0" "85.6" "104.0" "" "" "" "" "" "" "" "" "" "" "107.3" "89.9" "50.8" "74.8" "91.2" "65.1" "79.3" "88.6" "66.8" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "11.423" "6" "3" "4" "3" "535" "57.2" "8.28" "9.62" "3" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Fragile X syndrome" "Degradation of GABA" "2" "0" "1.284" "1.111" "1.054" "1.293" "1.188" "0.833" "1.074" "1.018" "1.387" "39.1" "50.2" "43.4" "41.2" "50.6" "46.4" "32.6" "42.0" "39.8" "54.2" "" "" "" "" "" "" "" "" "" "" "39.1" "42.5" "27.5" "30.0" "41.4" "36.1" "25.1" "36.1" "31.1" "48.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "11.414" "6" "1" "6" "1" "225" "24.3" "7.94" "15.93" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "Ciliary landscape" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.123" "0.947" "0.851" "0.931" "0.973" "1.013" "0.957" "1.034" "1.055" "54.5" "61.2" "51.6" "46.4" "50.7" "53.0" "55.2" "52.2" "56.4" "57.5" "" "" "" "" "" "" "" "" "" "" "54.5" "51.8" "32.6" "33.8" "41.6" "41.2" "42.5" "44.9" "44.0" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117817819398789718" "False" "High" "IsMasterProtein" "Q9P2X3" "Protein IMPACT OS=Homo sapiens OX=9606 GN=IMPACT PE=1 SV=2" "0.000" "False" "11.413" "9" "2" "2" "2" "320" "36.5" "4.97" "8.98" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;translation activity;other molecular function" "Pf01205, Pf05773" "55364" "ENSG00000154059" "IMPACT" "A8MXG0; hsa:55364; Q49AM0; Q9H2X4; Q9P2X3" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "1.083" "0.771" "0.978" "1.277" "0.999" "1.096" "0.983" "0.947" "0.933" "33.8" "36.6" "26.0" "33.0" "43.1" "33.7" "37.0" "33.2" "32.0" "31.5" "" "" "" "" "" "" "" "" "" "" "33.8" "30.9" "16.5" "24.1" "35.3" "26.2" "28.5" "28.5" "24.9" "28.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "11.407" "5" "2" "2" "2" "522" "53.2" "5.31" "8.98" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "7q11.23 copy number variation syndrome" "HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "30" "0" "1.046" "0.917" "1.058" "0.996" "0.893" "1.230" "0.855" "0.851" "0.882" "45.3" "47.3" "41.5" "47.9" "45.1" "40.4" "55.7" "38.7" "38.5" "39.9" "" "" "" "" "" "" "" "" "" "" "45.3" "40.1" "26.2" "34.9" "37.0" "31.4" "42.9" "33.3" "30.1" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "11.405" "19" "3" "3" "3" "210" "23.1" "8.69" "8.30" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "11.402" "8" "3" "3" "3" "492" "53.8" "4.70" "10.71" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "" "Neutrophil degranulation" "1" "0" "1.137" "1.019" "0.958" "1.120" "1.024" "0.828" "0.889" "1.199" "1.299" "18.9" "21.5" "19.3" "18.1" "21.2" "19.4" "15.7" "16.8" "22.7" "24.5" "" "" "" "" "" "" "" "" "" "" "18.9" "18.2" "12.2" "13.2" "17.4" "15.0" "12.1" "14.5" "17.7" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "11.385" "10" "3" "3" "3" "338" "38.7" "5.87" "11.50" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "0.820" "0.656" "1.048" "1.108" "0.718" "1.147" "1.051" "0.693" "0.863" "122.2" "100.2" "80.2" "128.1" "135.5" "87.7" "140.2" "128.5" "84.6" "105.5" "" "" "" "" "" "" "" "" "" "" "122.2" "84.8" "50.7" "93.4" "111.0" "68.1" "108.1" "110.5" "66.1" "94.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "11.382" "5" "3" "4" "3" "514" "57.6" "9.42" "15.14" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "1.011" "1.737" "0.967" "0.994" "1.714" "1.104" "1.061" "1.551" "1.155" "213.9" "216.2" "371.5" "206.9" "212.7" "366.6" "236.1" "226.9" "331.7" "247.0" "" "" "" "" "" "" "" "" "" "" "213.9" "182.9" "234.9" "150.9" "174.2" "284.7" "182.0" "195.1" "258.9" "222.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "11.376" "8" "4" "5" "3" "401" "44.9" "5.97" "10.59" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "1" "1.098" "1.600" "1.106" "1.071" "1.659" "1.131" "1.204" "1.525" "1.219" "110.7" "121.5" "177.0" "122.4" "118.5" "183.6" "125.2" "133.2" "168.8" "134.9" "" "" "" "" "" "" "" "" "" "" "110.7" "102.8" "111.9" "89.2" "97.1" "142.5" "96.5" "114.5" "131.7" "121.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "11.375" "9" "3" "3" "3" "299" "34.6" "5.36" "8.99" "3" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "11.372" "18" "4" "6" "4" "214" "24.6" "10.08" "15.63" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.032" "1.168" "1.048" "1.057" "1.262" "1.183" "1.251" "1.251" "1.052" "203.3" "209.8" "237.5" "213.1" "214.9" "256.5" "240.5" "254.3" "254.4" "213.9" "" "" "" "" "" "" "" "" "" "" "203.3" "177.5" "150.2" "155.4" "176.1" "199.2" "185.4" "218.7" "198.6" "192.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "11.365" "9" "3" "3" "3" "377" "41.9" "6.65" "12.26" "3" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "0.936" "1.045" "0.926" "0.872" "0.968" "0.881" "0.987" "1.114" "0.939" "392.0" "367.1" "409.8" "363.1" "342.0" "379.7" "345.4" "387.1" "436.9" "368.1" "" "" "" "" "" "" "" "" "" "" "392.0" "310.6" "259.1" "264.8" "280.2" "294.9" "266.2" "332.8" "341.0" "331.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "11.344" "12" "3" "3" "3" "213" "23.9" "8.76" "11.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "" "Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.021" "0.949" "1.066" "0.927" "0.895" "0.963" "0.982" "1.027" "0.920" "437.5" "446.7" "415.2" "466.4" "405.5" "391.8" "421.2" "429.5" "449.2" "402.4" "" "" "" "" "" "" "" "" "" "" "437.5" "377.9" "262.5" "340.0" "332.2" "304.3" "324.7" "369.2" "350.6" "361.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2147212707680779052" "False" "High" "IsMasterProtein" "P49427" "Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2" "0.000" "False" "11.334" "16" "4" "4" "4" "236" "26.7" "4.54" "12.39" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "997" "ENSG00000099804" "CDC34" "A8K689; hsa:997; P49427" "Vitamin D receptor pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "6" "0" "0.932" "0.879" "1.129" "0.964" "0.727" "1.022" "0.957" "0.845" "0.999" "153.7" "143.2" "135.1" "173.4" "148.2" "111.8" "157.0" "147.0" "129.9" "153.5" "" "" "" "" "" "" "" "" "" "" "153.7" "121.2" "85.4" "126.5" "121.4" "86.8" "121.0" "126.4" "101.4" "138.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "11.328" "17" "3" "4" "3" "194" "21.1" "5.01" "8.28" "3" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "11.318" "2" "2" "4" "2" "916" "104.4" "6.93" "14.16" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "8" "0" "0.935" "0.980" "1.164" "1.121" "0.885" "0.990" "1.014" "1.044" "0.955" "102.1" "95.4" "100.1" "118.8" "114.5" "90.3" "101.1" "103.5" "106.6" "97.5" "" "" "" "" "" "" "" "" "" "" "102.1" "80.8" "63.3" "86.6" "93.8" "70.2" "77.9" "89.0" "83.2" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "11.313" "10" "2" "3" "2" "249" "27.4" "8.06" "8.92" "2" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.161" "1.050" "1.188" "1.123" "1.331" "1.341" "1.116" "1.056" "1.315" "59.4" "69.0" "62.4" "70.6" "66.7" "79.1" "79.7" "66.3" "62.7" "78.1" "" "" "" "" "" "" "" "" "" "" "59.4" "58.4" "39.4" "51.5" "54.6" "61.4" "61.4" "57.0" "49.0" "70.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "11.296" "10" "3" "5" "3" "354" "39.1" "6.44" "14.59" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "27" "0" "1.296" "0.864" "1.415" "1.246" "0.963" "1.196" "1.156" "0.996" "1.228" "80.2" "104.0" "69.3" "113.5" "100.0" "77.3" "95.9" "92.8" "79.9" "98.6" "" "" "" "" "" "" "" "" "" "" "80.2" "88.0" "43.8" "82.8" "81.9" "60.0" "74.0" "79.7" "62.4" "88.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "11.290" "8" "4" "6" "2" "512" "58.5" "7.11" "16.88" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "FCERI mediated NF-kB activation; FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; Cyclin D associated events in G1; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; Dectin-2 family" "45" "0" "1.093" "0.988" "1.026" "0.938" "1.315" "1.007" "0.996" "1.076" "1.072" "42.8" "46.7" "42.2" "43.9" "40.1" "56.3" "43.1" "42.6" "46.0" "45.9" "" "" "" "" "" "" "" "" "" "" "42.8" "39.5" "26.7" "32.0" "32.9" "43.7" "33.2" "36.6" "35.9" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1845643412684317790" "False" "High" "IsMasterProtein" "P49674" "Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1" "0.000" "False" "11.285" "7" "3" "3" "3" "416" "47.3" "9.66" "9.04" "3" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "102800317; 1454" "ENSG00000213923" "CSNK1E" "hsa:102800317; hsa:1454; P49674" "Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease" "Regulation of PLK1 Activity at G2/M Transition; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock; Major pathway of rRNA processing in the nucleolus and cytosol" "20" "0" "1.014" "0.748" "1.010" "1.005" "0.879" "1.046" "0.971" "0.810" "0.959" "242.1" "245.5" "181.1" "244.6" "243.4" "212.9" "253.4" "235.1" "196.1" "232.3" "" "" "" "" "" "" "" "" "" "" "242.1" "207.7" "114.5" "178.4" "199.4" "165.3" "195.3" "202.2" "153.1" "208.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1130505086342919631" "False" "High" "IsMasterProtein" "Q99704" "Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1" "0.000" "False" "11.282" "10" "3" "3" "3" "481" "52.4" "6.47" "10.17" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00169, Pf02174" "1796" "ENSG00000115325" "DOK1" "hsa:1796; O43204; Q53TY2; Q99704; Q9UHG6" "Kit receptor signaling pathway; VEGFA-VEGFR2 signaling; GDNF signaling" "RET signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1" "5" "0" "0.849" "0.826" "1.015" "1.156" "0.745" "1.007" "0.985" "0.995" "0.880" "77.8" "66.1" "64.3" "79.0" "89.9" "58.0" "78.3" "76.6" "77.3" "68.5" "" "" "" "" "" "" "" "" "" "" "77.8" "55.9" "40.6" "57.6" "73.7" "45.0" "60.4" "65.8" "60.4" "61.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "11.273" "22" "3" "4" "3" "147" "15.7" "6.30" "13.69" "3" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "3" "0" "0.765" "0.861" "0.825" "0.764" "1.014" "0.841" "0.733" "1.064" "0.840" "255.0" "195.2" "219.6" "210.3" "194.8" "258.6" "214.6" "186.8" "271.3" "214.2" "" "" "" "" "" "" "" "" "" "" "255.0" "165.1" "138.8" "153.3" "159.6" "200.8" "165.4" "160.6" "211.7" "192.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1698124095596496194" "False" "High" "IsMasterProtein" "Q14147" "Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens OX=9606 GN=DHX34 PE=1 SV=2" "0.000" "False" "11.271" "3" "4" "4" "4" "1143" "128.0" "7.56" "12.25" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9704" "ENSG00000134815" "DHX34" "B4DMY8; hsa:9704; Q14147" "" "" "0" "0" "1.049" "0.739" "1.118" "0.940" "0.714" "1.069" "1.055" "0.859" "0.924" "41.6" "43.6" "30.7" "46.5" "39.1" "29.7" "44.4" "43.8" "35.7" "38.4" "" "" "" "" "" "" "" "" "" "" "41.6" "36.9" "19.4" "33.9" "32.0" "23.1" "34.2" "37.7" "27.9" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "11.267" "1" "4" "4" "4" "3859" "437.3" "8.19" "12.72" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Rett syndrome" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8718116979404921777" "False" "High" "IsMasterProtein" "P51116" "RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "0.000" "False" "11.262" "4" "3" "3" "1" "673" "74.2" "6.23" "10.74" "3" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.007" "1.172" "0.880" "0.942" "1.013" "1.007" "1.297" "1.047" "1.123" "20.3" "20.4" "23.8" "17.8" "19.1" "20.5" "20.4" "26.3" "21.2" "22.8" "" "" "" "" "" "" "" "" "" "" "20.3" "17.3" "15.0" "13.0" "15.6" "15.9" "15.7" "22.6" "16.6" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.000" "False" "11.259" "9" "2" "4" "2" "271" "28.8" "5.83" "14.24" "2" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.122" "0.829" "1.117" "1.084" "0.788" "1.036" "1.164" "0.735" "0.889" "200.3" "224.7" "166.1" "223.7" "217.2" "157.8" "207.6" "233.2" "147.3" "178.1" "" "" "" "" "" "" "" "" "" "" "200.3" "190.1" "105.0" "163.1" "177.9" "122.5" "160.0" "200.5" "115.0" "160.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "11.255" "20" "5" "5" "5" "222" "25.4" "5.33" "13.93" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "1.056" "1.101" "1.050" "0.952" "0.939" "0.968" "1.008" "1.149" "1.153" "187.9" "198.5" "207.0" "197.4" "178.9" "176.5" "181.9" "189.4" "216.0" "216.7" "" "" "" "" "" "" "" "" "" "" "187.9" "167.9" "130.9" "143.9" "146.6" "137.0" "140.2" "162.8" "168.6" "194.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "11.247" "5" "1" "2" "1" "308" "33.9" "4.84" "6.99" "1" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "" "NoRC negatively regulates rRNA expression" "1" "0" "1.461" "1.170" "1.211" "1.233" "1.443" "1.373" "1.432" "1.474" "1.083" "28.1" "41.0" "32.8" "34.0" "34.6" "40.5" "38.6" "40.2" "41.4" "30.4" "" "" "" "" "" "" "" "" "" "" "28.1" "34.7" "20.8" "24.8" "28.4" "31.5" "29.7" "34.6" "32.3" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.000" "False" "11.231" "14" "3" "4" "3" "225" "26.0" "5.78" "11.47" "3" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "1.010" "1.003" "0.887" "0.884" "1.066" "0.971" "1.015" "1.094" "0.987" "266.3" "268.8" "266.9" "236.2" "235.5" "283.8" "258.6" "270.2" "291.3" "262.7" "" "" "" "" "" "" "" "" "" "" "266.3" "227.5" "168.8" "172.2" "192.9" "220.4" "199.3" "232.3" "227.3" "236.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "11.228" "19" "3" "4" "3" "172" "19.3" "5.54" "12.29" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Pyrimidine metabolism; Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.795" "1.270" "1.038" "1.020" "1.080" "1.238" "1.022" "0.970" "1.176" "75.0" "59.7" "95.3" "77.9" "76.5" "81.0" "92.9" "76.6" "72.8" "88.2" "" "" "" "" "" "" "" "" "" "" "75.0" "50.5" "60.2" "56.8" "62.7" "62.9" "71.6" "65.9" "56.8" "79.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "High" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.000" "False" "11.203" "3" "2" "2" "2" "1216" "134.5" "5.45" "7.58" "2" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "1.216" "1.074" "1.173" "1.163" "1.013" "1.127" "1.215" "0.911" "1.103" "56.5" "68.7" "60.7" "66.3" "65.7" "57.2" "63.7" "68.7" "51.5" "62.4" "" "" "" "" "" "" "" "" "" "" "56.5" "58.1" "38.4" "48.3" "53.9" "44.4" "49.1" "59.1" "40.2" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "11.191" "14" "3" "3" "3" "187" "21.6" "7.59" "9.31" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "0.895" "0.593" "0.893" "1.044" "0.895" "1.109" "0.827" "0.793" "0.892" "49.9" "44.7" "29.6" "44.6" "52.1" "44.7" "55.4" "41.3" "39.6" "44.5" "" "" "" "" "" "" "" "" "" "" "49.9" "37.8" "18.7" "32.5" "42.7" "34.7" "42.7" "35.5" "30.9" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "High" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.000" "False" "11.187" "7" "3" "3" "3" "413" "43.9" "4.75" "9.99" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "14" "0" "0.954" "0.840" "1.117" "1.154" "0.934" "1.095" "1.116" "0.835" "0.963" "170.7" "162.8" "143.4" "190.8" "197.0" "159.5" "187.0" "190.5" "142.5" "164.5" "" "" "" "" "" "" "" "" "" "" "170.7" "137.7" "90.7" "139.1" "161.4" "123.9" "144.1" "163.8" "111.2" "147.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "11.176" "17" "2" "3" "2" "110" "11.5" "6.73" "9.57" "2" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "1.256" "1.019" "1.239" "1.228" "1.242" "1.311" "1.118" "1.059" "1.159" "70.5" "88.5" "71.8" "87.3" "86.6" "87.6" "92.4" "78.8" "74.6" "81.7" "" "" "" "" "" "" "" "" "" "" "70.5" "74.9" "45.4" "63.7" "70.9" "68.0" "71.2" "67.8" "58.3" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173280212815183212" "False" "High" "IsMasterProtein" "Q2M385" "Macrophage-expressed gene 1 protein OS=Homo sapiens OX=9606 GN=MPEG1 PE=1 SV=1" "0.000" "False" "11.171" "5" "4" "4" "4" "716" "78.5" "7.65" "11.78" "4" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01823" "219972" "ENSG00000197629" "MPEG1" "hsa:219972; Q2M1T6; Q2M385; Q8TEF8" "" "" "0" "0" "1.155" "0.846" "1.100" "1.324" "1.181" "1.273" "1.222" "1.115" "1.044" "40.2" "46.4" "34.0" "44.2" "53.2" "47.4" "51.1" "49.1" "44.8" "41.9" "" "" "" "" "" "" "" "" "" "" "40.2" "39.2" "21.5" "32.2" "43.6" "36.8" "39.4" "42.2" "34.9" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.000" "False" "11.171" "7" "4" "5" "4" "542" "62.1" "7.12" "15.51" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "12" "0" "1.088" "1.125" "1.127" "1.111" "1.130" "1.085" "1.139" "1.164" "1.104" "236.7" "257.6" "266.2" "266.7" "263.0" "267.5" "256.7" "269.7" "275.5" "261.3" "" "" "" "" "" "" "" "" "" "" "236.7" "217.9" "168.3" "194.5" "215.5" "207.8" "197.9" "231.9" "215.0" "234.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9132635867397603913" "False" "High" "IsMasterProtein" "Q53T59" "HCLS1-binding protein 3 OS=Homo sapiens OX=9606 GN=HS1BP3 PE=1 SV=1" "0.000" "False" "11.162" "9" "3" "3" "3" "392" "42.8" "5.01" "10.11" "3" "other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00787" "64342" "ENSG00000118960" "HS1BP3" "B2RAW2; D6W529; hsa:64342; Q53T59; Q86VC2; Q8N367" "" "" "0" "0" "1.209" "1.042" "1.516" "1.243" "1.145" "1.492" "1.223" "1.168" "1.162" "27.4" "33.1" "28.5" "41.5" "34.0" "31.3" "40.8" "33.4" "32.0" "31.8" "" "" "" "" "" "" "" "" "" "" "27.4" "28.0" "18.0" "30.2" "27.9" "24.3" "31.5" "28.8" "24.9" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "11.149" "7" "5" "5" "4" "610" "68.5" "6.29" "10.15" "5" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "0.971" "0.871" "0.993" "0.925" "1.089" "0.942" "0.638" "1.028" "1.141" "37.5" "36.4" "32.7" "37.2" "34.7" "40.9" "35.3" "23.9" "38.6" "42.8" "" "" "" "" "" "" "" "" "" "" "37.5" "30.8" "20.7" "27.2" "28.4" "31.7" "27.2" "20.6" "30.1" "38.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "11.143" "4" "1" "2" "1" "357" "37.2" "5.76" "7.74" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "1.113" "1.207" "1.177" "1.344" "1.453" "1.321" "1.049" "1.102" "1.334" "45.5" "50.6" "54.9" "53.5" "61.1" "66.1" "60.1" "47.7" "50.1" "60.6" "" "" "" "" "" "" "" "" "" "" "45.5" "42.8" "34.7" "39.0" "50.1" "51.3" "46.3" "41.0" "39.1" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "11.140" "8" "3" "4" "2" "483" "53.0" "7.71" "9.32" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Metabolism of folate and pterines; Carnitine synthesis" "13" "0" "1.033" "1.111" "0.963" "1.140" "1.171" "1.106" "1.120" "1.101" "1.065" "146.7" "151.5" "163.0" "141.3" "167.2" "171.8" "162.2" "164.3" "161.6" "156.3" "" "" "" "" "" "" "" "" "" "" "146.7" "128.2" "103.1" "103.0" "137.0" "133.4" "125.1" "141.2" "126.2" "140.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2956258532807354033" "False" "High" "IsMasterProtein" "O00459" "Phosphatidylinositol 3-kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PIK3R2 PE=1 SV=2" "0.000" "False" "11.136" "5" "4" "4" "3" "728" "81.5" "6.43" "14.67" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5296" "ENSG00000105647" "PIK3R2" "hsa:5296; O00459; Q5EAT5; Q9UPH9" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle" "113" "0" "0.928" "0.939" "0.929" "0.915" "0.940" "0.969" "0.917" "0.945" "0.859" "180.8" "167.8" "169.8" "168.0" "165.5" "170.0" "175.3" "165.8" "170.9" "155.4" "" "" "" "" "" "" "" "" "" "" "180.8" "142.0" "107.4" "122.5" "135.6" "132.0" "135.1" "142.6" "133.4" "139.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3889870800150504402" "False" "High" "IsMasterProtein" "Q8N5C8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 OS=Homo sapiens OX=9606 GN=TAB3 PE=1 SV=3" "0.000" "False" "11.123" "6" "3" "4" "3" "712" "78.6" "8.54" "6.23" "3" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02845" "257397" "ENSG00000157625" "TAB3" "A6NDD9; Q6VQR0; Q8N5C8" "IL-1 signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "18" "0" "1.165" "0.740" "1.054" "0.975" "0.760" "1.315" "1.124" "0.963" "0.894" "41.8" "48.7" "30.9" "44.0" "40.7" "31.8" "54.9" "47.0" "40.2" "37.3" "" "" "" "" "" "" "" "" "" "" "41.8" "41.2" "19.5" "32.1" "33.4" "24.7" "42.3" "40.4" "31.4" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3668723528538727638" "False" "High" "IsMasterProtein" "Q9UDT6" "CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1" "0.000" "False" "11.115" "3" "3" "3" "2" "1046" "115.8" "6.73" "9.46" "3" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302" "7461" "ENSG00000106665" "CLIP2" "hsa:7461; O14527; O43611; Q9UDT6" "7q11.23 copy number variation syndrome" "" "1" "0" "0.857" "0.988" "0.881" "1.083" "0.911" "0.768" "0.930" "0.806" "0.962" "25.5" "21.9" "25.2" "22.5" "27.7" "23.3" "19.6" "23.8" "20.6" "24.6" "" "" "" "" "" "" "" "" "" "" "25.5" "18.5" "16.0" "16.4" "22.7" "18.1" "15.1" "20.4" "16.1" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2089333689475724176" "False" "High" "IsMasterProtein" "Q9BTM9" "Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1" "0.000" "False" "11.112" "13" "1" "2" "1" "101" "11.4" "4.67" "9.40" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09138" "81605" "ENSG00000167118" "URM1" "B3KMH3; B4DV08; hsa:81605; Q5T4B4; Q9BTM9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.039" "1.039" "1.026" "0.993" "0.930" "1.081" "0.973" "0.981" "1.042" "141.0" "146.5" "146.4" "144.6" "140.0" "131.1" "152.4" "137.2" "138.3" "146.9" "" "" "" "" "" "" "" "" "" "" "141.0" "124.0" "92.6" "105.4" "114.7" "101.8" "117.4" "117.9" "108.0" "132.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "11.112" "12" "3" "3" "3" "264" "30.5" "9.80" "10.11" "3" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.972" "0.977" "1.117" "0.999" "1.079" "1.169" "0.982" "1.086" "1.001" "217.1" "211.1" "212.1" "242.6" "217.0" "234.2" "253.9" "213.2" "235.8" "217.3" "" "" "" "" "" "" "" "" "" "" "217.1" "178.6" "134.1" "176.9" "177.8" "181.9" "195.7" "183.3" "184.1" "195.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "11.093" "14" "4" "4" "4" "347" "39.3" "7.43" "10.52" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "34" "0" "1.131" "0.858" "1.072" "1.026" "0.749" "1.004" "1.056" "0.753" "0.960" "136.1" "153.9" "116.7" "145.9" "139.6" "101.9" "136.6" "143.7" "102.4" "130.6" "" "" "" "" "" "" "" "" "" "" "136.1" "130.2" "73.8" "106.4" "114.3" "79.1" "105.3" "123.5" "80.0" "117.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "11.090" "8" "2" "2" "2" "375" "41.9" "5.44" "7.64" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "4" "0" "0.901" "0.823" "0.795" "1.175" "0.893" "1.100" "1.080" "0.871" "0.773" "32.2" "29.1" "26.6" "25.6" "37.9" "28.8" "35.5" "34.8" "28.1" "24.9" "" "" "" "" "" "" "" "" "" "" "32.2" "24.6" "16.8" "18.7" "31.0" "22.4" "27.4" "29.9" "21.9" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "11.083" "5" "4" "5" "4" "726" "81.1" "5.72" "11.07" "4" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "0.987" "1.313" "0.953" "0.953" "1.196" "1.030" "0.940" "1.422" "0.926" "109.9" "108.5" "144.3" "104.8" "104.8" "131.5" "113.2" "103.3" "156.3" "101.7" "" "" "" "" "" "" "" "" "" "" "109.9" "91.8" "91.3" "76.4" "85.8" "102.1" "87.3" "88.8" "122.0" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8773613525593829658" "False" "High" "IsMasterProtein" "Q9NPJ8" "NTF2-related export protein 2 OS=Homo sapiens OX=9606 GN=NXT2 PE=1 SV=1" "0.000" "False" "11.074" "21" "3" "4" "3" "142" "16.2" "5.48" "11.00" "3" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "" "Pf02136" "55916" "ENSG00000101888" "NXT2" "D3DUY1; hsa:55916; Q0VAN8; Q5JYV5; Q5JYV6; Q5JYV7; Q9H8U0; Q9NPJ8; Q9NQ64; Q9NRL7; Q9Y3M4; Q9Y3M5" "" "" "0" "0" "1.039" "0.794" "0.979" "1.089" "0.924" "1.005" "1.076" "0.910" "1.000" "248.9" "258.7" "197.6" "243.7" "271.1" "230.0" "250.1" "267.8" "226.6" "249.0" "" "" "" "" "" "" "" "" "" "" "248.9" "218.9" "125.0" "177.7" "222.1" "178.6" "192.8" "230.2" "176.9" "223.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "11.071" "9" "4" "5" "4" "432" "48.5" "6.54" "11.47" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "27" "0" "0.993" "0.905" "1.167" "1.030" "1.076" "1.079" "1.077" "0.994" "0.964" "210.1" "208.6" "190.2" "245.2" "216.4" "226.1" "226.8" "226.4" "208.9" "202.5" "" "" "" "" "" "" "" "" "" "" "210.1" "176.5" "120.3" "178.8" "177.3" "175.6" "174.8" "194.6" "163.0" "182.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "11.066" "17" "4" "6" "4" "197" "22.4" "4.70" "17.13" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.974" "0.726" "1.099" "0.991" "0.769" "1.085" "0.953" "0.788" "0.948" "381.2" "371.4" "276.7" "419.0" "377.7" "293.3" "413.5" "363.2" "300.2" "361.5" "" "" "" "" "" "" "" "" "" "" "381.2" "314.2" "174.9" "305.5" "309.5" "227.8" "318.7" "312.3" "234.3" "325.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "11.048" "4" "3" "3" "3" "727" "83.9" "6.38" "10.99" "3" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "Primary ovarian insufficiency" "" "1" "0" "0.964" "0.937" "0.929" "0.977" "0.932" "0.883" "0.982" "0.878" "1.023" "311.2" "299.9" "291.7" "289.0" "304.2" "290.2" "274.7" "305.7" "273.3" "318.5" "" "" "" "" "" "" "" "" "" "" "311.2" "253.8" "184.5" "210.7" "249.2" "225.3" "211.8" "262.8" "213.3" "286.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "11.041" "6" "3" "5" "3" "579" "63.7" "8.87" "9.18" "3" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "1" "0" "1.517" "0.903" "1.587" "1.221" "1.249" "1.251" "0.992" "1.092" "1.292" "12.4" "18.8" "11.2" "19.7" "15.1" "15.5" "15.5" "12.3" "13.5" "16.0" "" "" "" "" "" "" "" "" "" "" "12.4" "15.9" "7.1" "14.3" "12.4" "12.0" "11.9" "10.6" "10.6" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620775136701769242" "False" "High" "IsMasterProtein" "P61764" "Syntaxin-binding protein 1 OS=Homo sapiens OX=9606 GN=STXBP1 PE=1 SV=1" "0.000" "False" "11.034" "5" "2" "2" "2" "594" "67.5" "6.96" "7.30" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00995" "6812" "ENSG00000136854" "STXBP1" "B1AM97; hsa:6812; P61764; Q28208; Q62759; Q64320; Q68CM6; Q96TG8" "Synaptic vesicle pathway; Rett syndrome; EGF/EGFR signaling pathway; Insulin signaling; 15q11q13 copy number variation" "Regulation of insulin secretion; Neurexins and neuroligins" "7" "0" "1.130" "1.062" "1.202" "1.028" "1.014" "1.021" "0.952" "1.088" "1.119" "184.6" "208.6" "196.1" "221.9" "189.9" "187.1" "188.5" "175.7" "200.9" "206.7" "" "" "" "" "" "" "" "" "" "" "184.6" "176.5" "124.0" "161.8" "155.6" "145.3" "145.3" "151.1" "156.8" "185.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4865533649162524419" "False" "High" "IsMasterProtein" "P28702" "Retinoic acid receptor RXR-beta OS=Homo sapiens OX=9606 GN=RXRB PE=1 SV=2" "0.000" "False" "11.029" "6" "4" "5" "2" "533" "56.9" "8.18" "14.29" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "6257" "ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712" "RXRB" "hsa:6257; P28702; P28703; Q59G65; Q5JP92; Q5STQ1" "Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "PPARA activates gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "18" "1" "1.037" "0.768" "0.967" "0.997" "0.812" "0.905" "1.018" "0.859" "0.925" "124.4" "129.0" "95.5" "120.3" "124.0" "101.0" "112.6" "126.6" "106.9" "115.1" "" "" "" "" "" "" "" "" "" "" "124.4" "109.1" "60.4" "87.7" "101.6" "78.5" "86.8" "108.9" "83.4" "103.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "11.017" "11" "3" "4" "3" "296" "33.4" "10.01" "10.59" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.709" "0.956" "0.860" "1.056" "0.972" "0.775" "0.894" "0.908" "1.027" "44.2" "31.3" "42.2" "38.0" "46.7" "43.0" "34.3" "39.5" "40.1" "45.4" "" "" "" "" "" "" "" "" "" "" "44.2" "26.5" "26.7" "27.7" "38.3" "33.4" "26.4" "34.0" "31.3" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726167102893575460" "False" "High" "IsMasterProtein" "Q7Z4H7" "HAUS augmin-like complex subunit 6 OS=Homo sapiens OX=9606 GN=HAUS6 PE=1 SV=2" "0.000" "False" "11.011" "4" "4" "5" "4" "955" "108.6" "6.47" "13.87" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14661" "54801" "ENSG00000147874" "HAUS6" "B3KPK4; B4DX82; hsa:54801; Q05CG1; Q14CB6; Q14CD9; Q2TA91; Q6IQ10; Q6NZX5; Q7Z4H7; Q8IZQ4; Q96FN0; Q9H950; Q9H998; Q9HCJ8; Q9NXT8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.068" "1.045" "1.054" "1.072" "0.828" "1.136" "1.078" "0.932" "1.015" "201.3" "214.9" "210.3" "212.1" "215.8" "166.6" "228.6" "217.0" "187.7" "204.3" "" "" "" "" "" "" "" "" "" "" "201.3" "181.8" "133.0" "154.7" "176.8" "129.4" "176.2" "186.6" "146.5" "183.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "10.993" "8" "3" "3" "2" "367" "41.9" "6.39" "10.85" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "30" "0" "0.980" "0.916" "1.020" "0.976" "0.872" "0.962" "0.953" "1.009" "1.092" "160.5" "157.3" "147.0" "163.7" "156.6" "140.0" "154.3" "153.0" "161.9" "175.2" "" "" "" "" "" "" "" "" "" "" "160.5" "133.0" "92.9" "119.4" "128.3" "108.7" "119.0" "131.5" "126.3" "157.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "10.991" "8" "3" "3" "3" "403" "45.8" "9.39" "9.67" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "10.981" "24" "2" "4" "2" "85" "9.8" "6.81" "10.84" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "18" "0" "1.021" "0.869" "1.040" "1.204" "0.966" "1.300" "1.126" "0.960" "0.964" "173.7" "177.3" "151.0" "180.7" "209.2" "167.8" "225.9" "195.6" "166.8" "167.5" "" "" "" "" "" "" "" "" "" "" "173.7" "150.0" "95.5" "131.7" "171.4" "130.3" "174.1" "168.2" "130.2" "150.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.000" "False" "10.960" "20" "2" "2" "2" "163" "17.6" "10.30" "9.60" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "1.484" "1.012" "1.387" "1.358" "1.285" "1.329" "1.408" "1.498" "1.308" "34.4" "51.1" "34.8" "47.7" "46.8" "44.2" "45.7" "48.5" "51.6" "45.0" "" "" "" "" "" "" "" "" "" "" "34.4" "43.2" "22.0" "34.8" "38.3" "34.4" "35.3" "41.7" "40.3" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7695782687359326445" "False" "High" "IsMasterProtein" "Q13342" "Nuclear body protein SP140 OS=Homo sapiens OX=9606 GN=SP140 PE=1 SV=2" "0.000" "False" "10.951" "5" "4" "4" "4" "867" "98.2" "5.27" "13.31" "4" "stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01342, Pf03172" "11262" "ENSG00000079263" "SP140" "E7ESH9; E7EUR5; E9PFJ6; hsa:11262; Q0VGE5; Q13341; Q13342; Q3KR17; Q4ZG66; Q53TG1; Q6NSG4; Q92881; Q96TG3" "" "" "0" "0" "1.140" "1.130" "1.145" "1.167" "1.037" "1.169" "1.115" "1.142" "1.153" "199.1" "226.9" "225.0" "227.9" "232.3" "206.5" "232.7" "222.1" "227.3" "229.4" "" "" "" "" "" "" "" "" "" "" "199.1" "192.0" "142.3" "166.2" "190.3" "160.4" "179.4" "190.9" "177.4" "206.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "10.951" "2" "3" "3" "3" "1435" "160.9" "6.87" "8.30" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.055" "0.756" "1.053" "1.160" "0.951" "1.129" "1.146" "0.965" "1.030" "122.9" "129.6" "93.0" "129.5" "142.6" "116.8" "138.7" "140.9" "118.6" "126.6" "" "" "" "" "" "" "" "" "" "" "122.9" "109.7" "58.8" "94.4" "116.8" "90.7" "106.9" "121.1" "92.6" "113.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "10.943" "6" "3" "3" "3" "534" "60.6" "7.31" "9.74" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.029" "1.173" "1.216" "1.255" "1.214" "1.269" "1.242" "1.130" "1.064" "69.2" "71.2" "81.1" "84.1" "86.9" "84.0" "87.8" "86.0" "78.2" "73.6" "" "" "" "" "" "" "" "" "" "" "69.2" "60.2" "51.3" "61.3" "71.2" "65.2" "67.7" "73.9" "61.0" "66.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "10.917" "7" "2" "4" "2" "300" "33.2" "4.98" "13.40" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "" "HATs acetylate histones" "1" "0" "1.191" "0.951" "1.144" "1.079" "1.023" "0.875" "1.054" "0.918" "1.060" "78.1" "93.0" "74.3" "89.3" "84.2" "79.8" "68.3" "82.3" "71.7" "82.7" "" "" "" "" "" "" "" "" "" "" "78.1" "78.7" "47.0" "65.1" "69.0" "62.0" "52.7" "70.8" "55.9" "74.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7535964181824527260" "False" "High" "IsMasterProtein" "Q9H0E3" "Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1" "0.000" "False" "10.915" "3" "3" "3" "3" "1048" "110.3" "9.83" "9.34" "3" "other biological processes" "nucleus" "" "Pf16014" "79595" "ENSG00000136715" "SAP130" "B7ZLM3; C9K0X9; hsa:79595; Q4ZFV4; Q53T46; Q8WVW4; Q9H0E3; Q9H9G8" "" "NoRC negatively regulates rRNA expression; HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "10.912" "9" "4" "4" "4" "388" "41.8" "8.90" "10.30" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "Adipogenesis" "" "1" "0" "0.876" "0.813" "0.855" "0.805" "0.797" "0.932" "0.935" "0.671" "0.894" "163.7" "143.4" "133.2" "140.0" "131.8" "130.5" "152.6" "153.0" "109.8" "146.3" "" "" "" "" "" "" "" "" "" "" "163.7" "121.3" "84.2" "102.1" "108.0" "101.3" "117.7" "131.6" "85.7" "131.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "High" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.000" "False" "10.905" "3" "3" "4" "3" "859" "97.5" "6.55" "13.69" "3" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle" "9" "0" "0.981" "1.036" "1.012" "1.075" "1.002" "0.980" "0.998" "0.939" "0.997" "303.2" "297.4" "314.0" "306.9" "325.9" "303.7" "297.1" "302.6" "284.8" "302.4" "" "" "" "" "" "" "" "" "" "" "303.2" "251.6" "198.5" "223.8" "267.0" "235.8" "229.0" "260.2" "222.3" "271.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200197799913832465" "False" "High" "IsMasterProtein" "C9J798" "Ras GTPase-activating protein 4B OS=Homo sapiens OX=9606 GN=RASA4B PE=1 SV=2" "0.000" "False" "10.892" "3" "3" "3" "3" "803" "90.4" "7.74" "9.89" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "" "ENSG00000170667" "RASA4B" "C9J798" "Ras signaling" "" "1" "0" "1.049" "0.836" "1.065" "1.060" "0.795" "1.173" "1.073" "0.777" "0.991" "337.3" "353.8" "282.1" "359.3" "357.6" "268.3" "395.5" "362.0" "262.1" "334.4" "" "" "" "" "" "" "" "" "" "" "337.3" "299.3" "178.4" "262.0" "292.9" "208.3" "304.9" "311.3" "204.6" "300.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "10.891" "17" "4" "4" "4" "221" "24.5" "7.39" "13.71" "4" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.001" "1.169" "0.935" "0.864" "1.039" "0.932" "0.905" "1.080" "0.988" "363.4" "363.7" "424.8" "339.8" "314.1" "377.5" "338.5" "329.0" "392.4" "359.1" "" "" "" "" "" "" "" "" "" "" "363.4" "307.7" "268.6" "247.8" "257.4" "293.1" "260.9" "282.8" "306.3" "322.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "10.888" "8" "3" "4" "3" "301" "34.5" "4.82" "12.07" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "" "Processing of DNA double-strand break ends" "1" "0" "0.916" "0.844" "1.076" "1.244" "0.865" "1.224" "1.092" "0.914" "1.053" "122.6" "112.3" "103.5" "132.0" "152.6" "106.0" "150.1" "134.0" "112.1" "129.2" "" "" "" "" "" "" "" "" "" "" "122.6" "95.0" "65.4" "96.3" "125.0" "82.3" "115.7" "115.2" "87.5" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "10.881" "14" "3" "3" "2" "184" "21.4" "10.17" "10.33" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.909" "1.291" "1.061" "0.993" "1.288" "0.992" "1.289" "1.298" "0.942" "320.5" "291.3" "413.8" "339.9" "318.1" "412.7" "317.9" "413.0" "416.0" "301.8" "" "" "" "" "" "" "" "" "" "" "320.5" "246.4" "261.7" "247.8" "260.6" "320.5" "245.1" "355.1" "324.7" "271.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "High" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.000" "False" "10.868" "8" "2" "2" "2" "326" "37.0" "8.79" "7.92" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.111" "0.758" "0.886" "1.169" "0.875" "1.219" "0.709" "0.812" "1.285" "25.5" "28.3" "19.3" "22.6" "29.8" "22.3" "31.1" "18.1" "20.7" "32.7" "" "" "" "" "" "" "" "" "" "" "25.5" "24.0" "12.2" "16.5" "24.4" "17.3" "24.0" "15.5" "16.1" "29.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1386453636298102119" "False" "High" "IsMasterProtein" "Q8NDH3" "Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3" "0.000" "False" "10.853" "9" "4" "4" "4" "523" "55.8" "6.87" "7.92" "4" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf18295" "79716" "ENSG00000215440" "NPEPL1" "A6NGZ0; B4DMW7; B7ZBN0; E9PN47; G5EA34; hsa:79716; Q53G37; Q5W083; Q8NDH3; Q8TF28; Q8WUI2; Q9H1T6; Q9HAI5" "" "" "0" "0" "1.197" "1.105" "1.380" "1.155" "1.246" "1.124" "1.183" "1.117" "1.108" "85.3" "102.1" "94.2" "117.7" "98.5" "106.3" "95.8" "100.9" "95.3" "94.5" "" "" "" "" "" "" "" "" "" "" "85.3" "86.4" "59.6" "85.8" "80.7" "82.6" "73.9" "86.7" "74.4" "84.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "10.846" "16" "3" "11" "3" "154" "17.9" "8.51" "34.66" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "7" "0" "0.891" "0.999" "0.937" "0.976" "1.038" "1.068" "0.911" "1.006" "0.988" "1377.1" "1226.4" "1375.2" "1290.7" "1343.5" "1430.0" "1471.4" "1255.2" "1385.3" "1361.0" "" "" "" "" "" "" "" "" "" "" "1377.1" "1037.5" "869.6" "941.1" "1100.7" "1110.5" "1134.2" "1079.2" "1081.3" "1223.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037316955710450301" "False" "High" "IsMasterProtein" "P38936" "Cyclin-dependent kinase inhibitor 1 OS=Homo sapiens OX=9606 GN=CDKN1A PE=1 SV=3" "0.000" "False" "10.843" "11" "1" "2" "1" "164" "18.1" "8.37" "6.29" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf02234" "1026" "ENSG00000124762" "CDKN1A" "hsa:1026; P38936; Q14010; Q6FI05; Q9BUT4" "Androgen receptor signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Glioblastoma signaling pathways; Adipogenesis; Retinoblastoma gene in cancer; ATM signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; Photodynamic therapy-induced AP-1 survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; Physico-chemical features and toxicity-associated pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Type 2 papillary renal cell carcinoma; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; FGF23 signaling in hypophosphatemic rickets and related disorders; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; Galanin receptor pathway; Pleural mesothelioma; Orexin receptor pathway; Lipid metabolism in senescent cells; Pathophysiological roles of DUX4 in FSHD1; Omega-6-fatty acids in senescence; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent); Androgen receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); Signaling by ALK fusions and activated point mutants; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; The role of GTSE1 in G2/M progression after G2 checkpoint; Neddylation; KEAP1-NFE2L2 pathway; Constitutive Signaling by AKT1 E17K in Cancer; SCF(Skp2)-mediated degradation of p27/p21; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; Transcriptional regulation by RUNX2; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; p53-Dependent G1 DNA Damage Response; TFAP2 (AP-2) family regulates transcription of cell cycle factors; Signaling by FLT3 fusion proteins; RUNX3 regulates CDKN1A transcription; Transcriptional activation of cell cycle inhibitor p21 ; STAT5 activation downstream of FLT3 ITD mutants" "79" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.000" "False" "10.814" "12" "2" "3" "2" "180" "19.7" "7.20" "10.14" "2" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "" "Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.942" "0.761" "1.057" "0.992" "0.720" "1.006" "1.071" "0.709" "0.924" "158.7" "149.6" "120.9" "167.8" "157.4" "114.3" "159.8" "170.0" "112.6" "146.6" "" "" "" "" "" "" "" "" "" "" "158.7" "126.5" "76.4" "122.3" "129.0" "88.8" "123.1" "146.1" "87.9" "131.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3630793398964430880" "False" "High" "IsMasterProtein" "Q58EX7" "Puratrophin-1 OS=Homo sapiens OX=9606 GN=PLEKHG4 PE=1 SV=1" "0.000" "False" "10.804" "4" "5" "6" "5" "1191" "130.7" "5.64" "14.45" "5" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00621" "25894" "ENSG00000196155" "PLEKHG4" "hsa:25894; Q4G0J8; Q4H485; Q56A69; Q58EX7; Q9H7K4; Q9UFW0" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "1.106" "1.047" "1.162" "1.107" "1.057" "1.159" "1.245" "0.998" "1.130" "208.5" "230.6" "218.2" "242.3" "230.7" "220.4" "241.7" "259.5" "208.0" "235.6" "" "" "" "" "" "" "" "" "" "" "208.5" "195.1" "138.0" "176.6" "189.1" "171.1" "186.3" "223.1" "162.4" "211.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5094634281983093833" "False" "High" "IsMasterProtein" "P57723" "Poly(rC)-binding protein 4 OS=Homo sapiens OX=9606 GN=PCBP4 PE=1 SV=1" "0.000" "False" "10.795" "5" "2" "4" "1" "403" "41.5" "8.16" "11.02" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "57060" "ENSG00000090097" "PCBP4" "hsa:57060; P57723; Q96AH7" "" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; FOXO-mediated transcription of cell cycle genes; Transcriptional activation of cell cycle inhibitor p21" "3" "0" "1.032" "0.814" "0.926" "1.085" "0.899" "1.080" "0.995" "0.819" "0.857" "153.6" "158.4" "125.1" "142.2" "166.7" "138.1" "166.0" "152.8" "125.8" "131.7" "" "" "" "" "" "" "" "" "" "" "153.6" "134.1" "79.1" "103.7" "136.5" "107.2" "127.9" "131.4" "98.2" "118.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "High" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.000" "False" "10.789" "4" "2" "2" "2" "477" "52.9" "6.62" "7.12" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "" "tRNA modification in the mitochondrion" "1" "0" "1.118" "1.078" "1.146" "1.060" "1.009" "1.209" "1.143" "1.135" "0.970" "140.5" "157.1" "151.4" "161.0" "148.9" "141.7" "169.9" "160.6" "159.5" "136.3" "" "" "" "" "" "" "" "" "" "" "140.5" "132.9" "95.7" "117.4" "122.0" "110.1" "130.9" "138.1" "124.5" "122.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6133561671554163995" "False" "High" "IsMasterProtein" "P43378" "Tyrosine-protein phosphatase non-receptor type 9 OS=Homo sapiens OX=9606 GN=PTPN9 PE=1 SV=1" "0.000" "False" "10.785" "6" "4" "4" "4" "593" "68.0" "8.02" "12.62" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00102, Pf00650" "5780" "ENSG00000169410" "PTPN9" "hsa:5780; P43378; Q53XR9" "VEGFA-VEGFR2 signaling" "Interleukin-37 signaling" "2" "0" "0.941" "0.908" "1.054" "1.028" "0.969" "1.102" "0.953" "0.941" "1.042" "151.7" "142.8" "137.8" "160.0" "156.0" "147.0" "167.2" "144.5" "142.7" "158.0" "" "" "" "" "" "" "" "" "" "" "151.7" "120.8" "87.1" "116.6" "127.8" "114.1" "128.9" "124.3" "111.4" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "10.783" "6" "2" "5" "2" "315" "35.1" "6.70" "15.59" "2" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "0.968" "1.082" "1.096" "1.064" "1.066" "0.939" "1.108" "1.030" "1.109" "148.8" "144.1" "161.1" "163.0" "158.3" "158.6" "139.7" "164.8" "153.2" "165.0" "" "" "" "" "" "" "" "" "" "" "148.8" "121.9" "101.8" "118.9" "129.7" "123.2" "107.7" "141.7" "119.6" "148.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "10.779" "9" "3" "3" "3" "339" "40.2" "6.83" "10.30" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.984" "1.021" "1.009" "1.066" "1.019" "0.994" "1.044" "0.942" "0.929" "498.7" "490.6" "509.4" "503.1" "531.7" "508.1" "495.6" "520.4" "469.6" "463.5" "" "" "" "" "" "" "" "" "" "" "498.7" "415.1" "322.1" "366.8" "435.6" "394.6" "382.0" "447.4" "366.5" "416.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "10.767" "8" "3" "4" "3" "390" "43.9" "6.46" "9.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Membrane binding and targetting of GAG proteins" "7" "0" "0.998" "0.755" "0.899" "1.116" "1.261" "0.955" "0.997" "0.949" "1.228" "41.3" "41.2" "31.2" "37.1" "46.1" "52.1" "39.4" "41.2" "39.2" "50.7" "" "" "" "" "" "" "" "" "" "" "41.3" "34.9" "19.7" "27.1" "37.7" "40.4" "30.4" "35.4" "30.6" "45.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "10.756" "4" "3" "3" "3" "1361" "151.5" "6.33" "10.39" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "" "RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3087130677209166127" "False" "High" "IsMasterProtein" "O43566" "Regulator of G-protein signaling 14 OS=Homo sapiens OX=9606 GN=RGS14 PE=1 SV=4" "0.000" "False" "10.740" "6" "2" "2" "2" "566" "61.4" "8.19" "8.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00615, Pf02188, Pf02196" "10636" "ENSG00000169220" "RGS14" "hsa:10636; O43565; O43566; Q506M1; Q6ZWA4; Q8TD62" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; 5q35 copy number variation" "G alpha (i) signalling events" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813799245873050122" "False" "High" "IsMasterProtein" "Q96L91" "E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4" "0.000" "False" "10.737" "1" "4" "4" "4" "3159" "343.3" "9.19" "8.27" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529, Pf15790" "57634" "ENSG00000183495" "EP400" "hsa:57634; O15411; Q6P2F5; Q8N8Q7; Q8NE05; Q96JK7; Q96L91; Q9P230" "HDAC6 interactions in the central nervous system" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); HATs acetylate histones" "4" "0" "1.328" "1.037" "0.899" "1.377" "0.957" "1.389" "1.360" "1.042" "1.054" "46.6" "61.9" "48.4" "41.9" "64.2" "44.6" "64.7" "63.4" "48.6" "49.1" "" "" "" "" "" "" "" "" "" "" "46.6" "52.4" "30.6" "30.6" "52.6" "34.6" "49.9" "54.5" "37.9" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8365125981762301712" "False" "High" "IsMasterProtein" "P52739" "Zinc finger protein 131 OS=Homo sapiens OX=9606 GN=ZNF131 PE=1 SV=2" "0.000" "False" "10.731" "2" "1" "2" "1" "623" "71.4" "5.19" "8.67" "1" "other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00651, Pf12874" "7690" "ENSG00000172262" "ZNF131" "B4DRL3; hsa:7690; P52739; Q6PIF0" "" "SUMOylation of transcription cofactors" "1" "0" "0.856" "0.862" "1.118" "1.069" "0.737" "0.988" "0.911" "0.749" "1.000" "71.4" "61.2" "61.5" "79.8" "76.3" "52.6" "70.5" "65.0" "53.5" "71.4" "" "" "" "" "" "" "" "" "" "" "71.4" "51.7" "38.9" "58.2" "62.5" "40.9" "54.4" "55.9" "41.7" "64.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "10.719" "5" "4" "5" "4" "857" "97.6" "7.58" "8.29" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994823038495086157" "False" "High" "IsMasterProtein" "Q02040" "A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2" "0.000" "False" "10.695" "4" "4" "4" "4" "695" "80.7" "9.73" "12.81" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "8227" "ENSG00000197976; ENSG00000292343" "AKAP17A" "hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9" "" "" "0" "0" "1.066" "1.306" "1.009" "1.083" "1.441" "1.090" "1.144" "1.232" "1.108" "169.9" "181.1" "221.9" "171.4" "184.0" "244.7" "185.1" "194.4" "209.2" "188.3" "" "" "" "" "" "" "" "" "" "" "169.9" "153.2" "140.3" "125.0" "150.8" "190.0" "142.7" "167.2" "163.3" "169.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "10.691" "11" "3" "3" "3" "244" "26.7" "9.17" "10.93" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5558821625919889641" "False" "High" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "0.000" "False" "10.686" "8" "2" "2" "1" "337" "37.8" "8.50" "8.25" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.090" "0.872" "1.070" "1.163" "1.052" "1.062" "1.143" "1.066" "0.981" "91.0" "99.3" "79.3" "97.4" "105.9" "95.8" "96.7" "104.1" "97.0" "89.3" "" "" "" "" "" "" "" "" "" "" "91.0" "84.0" "50.2" "71.0" "86.7" "74.4" "74.5" "89.5" "75.7" "80.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "10.685" "11" "2" "3" "2" "189" "20.7" "5.57" "8.88" "2" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "1.653" "1.002" "1.233" "1.708" "1.294" "1.854" "1.439" "1.030" "1.157" "10.9" "18.0" "10.9" "13.4" "18.6" "14.1" "20.2" "15.7" "11.2" "12.6" "" "" "" "" "" "" "" "" "" "" "10.9" "15.2" "6.9" "9.8" "15.2" "10.9" "15.6" "13.5" "8.8" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "10.671" "6" "1" "2" "1" "202" "23.0" "6.54" "8.41" "1" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "" "Neddylation" "1" "0" "1.016" "0.874" "1.005" "0.924" "0.943" "0.958" "0.790" "0.764" "0.980" "90.2" "91.6" "78.9" "90.6" "83.3" "85.1" "86.4" "71.3" "68.9" "88.4" "" "" "" "" "" "" "" "" "" "" "90.2" "77.5" "49.9" "66.1" "68.3" "66.1" "66.6" "61.3" "53.8" "79.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "364086976847350379" "False" "High" "IsMasterProtein" "Q7L592" "Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1" "0.000" "False" "10.653" "10" "4" "5" "4" "441" "49.2" "8.34" "12.84" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf02636" "55471" "ENSG00000003509" "NDUFAF7" "hsa:55471; Q7L592; Q7Z399; Q9P1G3" "" "Complex I biogenesis" "1" "0" "1.035" "1.031" "1.120" "1.150" "1.031" "1.093" "1.085" "1.077" "1.152" "130.6" "135.2" "134.6" "146.3" "150.2" "134.7" "142.8" "141.8" "140.7" "150.4" "" "" "" "" "" "" "" "" "" "" "130.6" "114.4" "85.1" "106.7" "123.1" "104.6" "110.1" "121.9" "109.8" "135.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "10.646" "10" "3" "3" "3" "304" "33.8" "5.55" "9.23" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "31" "0" "1.101" "1.122" "1.238" "1.305" "1.037" "1.153" "1.270" "1.239" "1.070" "109.7" "120.8" "123.1" "135.9" "143.2" "113.7" "126.5" "139.4" "136.0" "117.5" "" "" "" "" "" "" "" "" "" "" "109.7" "102.2" "77.8" "99.1" "117.3" "88.3" "97.5" "119.9" "106.1" "105.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3479204083364141985" "False" "High" "IsMasterProtein" "Q96IY1" "Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3" "0.000" "False" "10.635" "10" "2" "2" "2" "281" "32.1" "6.79" "7.15" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08641" "25936" "ENSG00000117697" "NSL1" "E7ETD5; hsa:25936; Q5SY75; Q96IY1; Q9H2M5; Q9NRN8; Q9Y415" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1889758281858521724" "False" "High" "IsMasterProtein" "Q53HC5" "Kelch-like protein 26 OS=Homo sapiens OX=9606 GN=KLHL26 PE=1 SV=2" "0.000" "False" "10.630" "6" "4" "4" "4" "615" "68.1" "6.48" "8.31" "4" "" "" "" "Pf00651, Pf01344, Pf07707, Pf13964" "55295" "ENSG00000167487" "KLHL26" "hsa:55295; Q53HC5; Q8TAP0; Q9NUX3" "" "" "0" "0" "0.993" "0.785" "1.090" "1.147" "0.839" "0.987" "1.050" "0.886" "0.931" "208.6" "207.0" "163.8" "227.4" "239.2" "174.9" "205.9" "218.9" "184.8" "194.2" "" "" "" "" "" "" "" "" "" "" "208.6" "175.2" "103.6" "165.8" "196.0" "135.8" "158.7" "188.2" "144.2" "174.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "10.620" "3" "3" "3" "3" "951" "104.8" "8.05" "10.05" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "mRNA processing" "" "1" "0" "1.065" "1.338" "1.082" "1.100" "1.514" "1.085" "0.925" "1.361" "1.238" "133.7" "142.4" "178.9" "144.6" "147.0" "202.4" "145.1" "123.7" "182.0" "165.6" "" "" "" "" "" "" "" "" "" "" "133.7" "120.5" "113.1" "105.4" "120.5" "157.2" "111.8" "106.3" "142.0" "148.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "10.620" "16" "5" "5" "5" "302" "32.8" "8.54" "9.85" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.027" "1.053" "1.100" "0.987" "1.096" "0.974" "0.972" "1.127" "1.120" "133.1" "136.7" "140.1" "146.3" "131.3" "145.8" "129.7" "129.3" "150.0" "149.0" "" "" "" "" "" "" "" "" "" "" "133.1" "115.6" "88.6" "106.7" "107.6" "113.2" "99.9" "111.2" "117.1" "134.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011732413234136033" "False" "High" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "0.000" "False" "10.619" "4" "4" "4" "4" "755" "85.0" "6.87" "10.78" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862, Pf21371" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Cell cycle" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "10.618" "17" "3" "4" "2" "193" "21.4" "8.53" "12.46" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "23" "1" "1.158" "1.139" "0.936" "1.035" "1.119" "0.996" "1.023" "1.031" "1.078" "217.5" "251.7" "247.6" "203.6" "225.1" "243.3" "216.5" "222.6" "224.1" "234.4" "" "" "" "" "" "" "" "" "" "" "217.5" "213.0" "156.6" "148.5" "184.5" "189.0" "166.9" "191.4" "174.9" "210.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288572419513908439" "False" "High" "IsMasterProtein" "Q8WXG6" "MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2" "0.000" "False" "10.611" "3" "4" "4" "4" "1647" "183.2" "6.04" "7.89" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02141, Pf03456" "8567" "ENSG00000110514" "MADD" "A8K8S7; B5MEE5; D3DQR4; hsa:8567; O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; Q8WXG6; Q8WZ63" "Apoptosis modulation and signaling; Deregulation of Rab and Rab effector genes in bladder cancer; TNF-alpha signaling pathway" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "High" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.000" "False" "10.610" "8" "3" "3" "3" "351" "40.3" "5.00" "10.03" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "VEGFA-VEGFR2 signaling" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.144" "1.002" "0.991" "1.229" "1.153" "1.137" "1.143" "0.968" "1.125" "126.0" "144.1" "126.2" "124.8" "154.8" "145.3" "143.3" "144.0" "121.9" "141.7" "" "" "" "" "" "" "" "" "" "" "126.0" "121.9" "79.8" "91.0" "126.8" "112.8" "110.4" "123.8" "95.2" "127.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "10.608" "7" "2" "2" "2" "341" "37.5" "7.43" "8.15" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.098" "0.928" "0.949" "1.125" "0.958" "1.291" "1.153" "1.115" "1.149" "42.5" "46.6" "39.4" "40.3" "47.8" "40.7" "54.9" "49.0" "47.4" "48.8" "" "" "" "" "" "" "" "" "" "" "42.5" "39.5" "24.9" "29.4" "39.1" "31.6" "42.3" "42.1" "37.0" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "10.598" "7" "3" "3" "3" "387" "43.6" "5.06" "11.15" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "Ciliary landscape" "" "1" "0" "1.086" "0.940" "1.130" "1.120" "1.126" "1.121" "1.224" "1.081" "1.107" "389.2" "422.7" "365.8" "439.8" "435.8" "438.4" "436.4" "476.6" "420.6" "430.7" "" "" "" "" "" "" "" "" "" "" "389.2" "357.6" "231.3" "320.7" "357.1" "340.5" "336.4" "409.8" "328.3" "387.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "10.596" "23" "3" "4" "3" "142" "15.6" "9.13" "10.25" "3" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "Complement system" "" "1" "0" "1.156" "1.131" "1.181" "1.091" "1.213" "1.095" "1.131" "1.207" "1.117" "233.0" "269.4" "263.5" "275.2" "254.3" "282.7" "255.1" "263.6" "281.4" "260.4" "" "" "" "" "" "" "" "" "" "" "233.0" "228.0" "166.6" "200.7" "208.3" "219.5" "196.7" "226.6" "219.6" "234.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "10.584" "5" "3" "3" "2" "619" "68.6" "6.18" "10.25" "3" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHO GTPases activate KTN1" "6" "0" "0.943" "0.832" "0.958" "0.895" "0.807" "0.824" "0.886" "0.885" "0.909" "110.4" "104.1" "91.9" "105.8" "98.8" "89.1" "91.0" "97.8" "97.7" "100.3" "" "" "" "" "" "" "" "" "" "" "110.4" "88.1" "58.1" "77.1" "81.0" "69.2" "70.1" "84.1" "76.3" "90.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.000" "False" "10.572" "10" "3" "3" "3" "308" "34.9" "6.28" "8.51" "3" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6159881748144421319" "False" "High" "IsMasterProtein" "Q9NQC7" "Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens OX=9606 GN=CYLD PE=1 SV=1" "0.000" "False" "10.565" "4" "4" "4" "4" "956" "107.2" "5.59" "11.29" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00443, Pf01302, Pf16607" "1540" "ENSG00000083799" "CYLD" "hsa:1540; O94934; Q7L3N6; Q96EH0; Q9NQC7; Q9NZX9" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling" "8" "0" "1.115" "0.868" "1.086" "1.122" "1.033" "1.130" "1.163" "1.042" "1.126" "68.0" "75.8" "59.0" "73.8" "76.3" "70.2" "76.9" "79.1" "70.8" "76.6" "" "" "" "" "" "" "" "" "" "" "68.0" "64.1" "37.3" "53.8" "62.5" "54.5" "59.2" "68.0" "55.3" "68.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5958960994699696402" "False" "High" "IsMasterProtein" "Q99081" "Transcription factor 12 OS=Homo sapiens OX=9606 GN=TCF12 PE=1 SV=1" "0.000" "False" "10.561" "5" "3" "3" "1" "682" "72.9" "7.02" "9.31" "3" "other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6938" "ENSG00000140262" "TCF12" "B4E1W1; hsa:6938; Q7Z3D9; Q86TC1; Q86VM2; Q99081" "" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription" "3" "0" "0.882" "0.717" "1.040" "1.302" "1.328" "1.070" "0.950" "0.869" "0.937" "42.0" "37.0" "30.1" "43.7" "54.6" "55.7" "44.9" "39.9" "36.5" "39.3" "" "" "" "" "" "" "" "" "" "" "42.0" "31.3" "19.0" "31.8" "44.8" "43.3" "34.6" "34.3" "28.5" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.000" "False" "10.551" "2" "2" "2" "2" "1424" "155.2" "7.47" "7.01" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression" "11" "0" "1.042" "0.851" "0.986" "1.166" "0.946" "1.140" "1.037" "0.841" "0.973" "104.6" "109.0" "89.1" "103.2" "122.0" "99.0" "119.2" "108.4" "88.0" "101.8" "" "" "" "" "" "" "" "" "" "" "104.6" "92.2" "56.3" "75.2" "99.9" "76.8" "91.9" "93.2" "68.7" "91.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "10.540" "2" "2" "3" "2" "1235" "135.3" "4.60" "9.56" "2" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "10.524" "5" "5" "6" "5" "902" "102.5" "6.84" "15.86" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.120" "0.858" "1.085" "1.141" "0.934" "1.101" "1.167" "0.846" "1.114" "53.9" "60.4" "46.3" "58.5" "61.5" "50.3" "59.4" "62.9" "45.6" "60.1" "" "" "" "" "" "" "" "" "" "" "53.9" "51.1" "29.2" "42.6" "50.4" "39.1" "45.8" "54.1" "35.6" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1051872101959425642" "False" "High" "IsMasterProtein" "O15519" "CASP8 and FADD-like apoptosis regulator OS=Homo sapiens OX=9606 GN=CFLAR PE=1 SV=1" "0.000" "False" "10.522" "5" "2" "2" "2" "480" "55.3" "8.00" "7.63" "2" "cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656, Pf01335" "8837" "ENSG00000003402" "CFLAR" "B4DJE0; B7Z9F9; hsa:8837; O14673; O14674; O14675; O15137; O15138; O15356; O15510; O15519; O43618; O43619; O43620; O60458; O60459; Q53TS6; Q54AF1; Q96TE4; Q9UEW1" "TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; IL-18 signaling pathway; 2q37 copy number variation syndrome" "TRAIL signaling" "9" "0" "1.088" "0.774" "0.872" "0.996" "0.988" "0.780" "1.067" "0.742" "0.997" "89.7" "97.6" "69.4" "78.2" "89.4" "88.6" "70.0" "95.7" "66.5" "89.5" "" "" "" "" "" "" "" "" "" "" "89.7" "82.6" "43.9" "57.0" "73.2" "68.8" "54.0" "82.3" "51.9" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.000" "False" "10.512" "11" "1" "2" "1" "145" "16.8" "9.16" "8.56" "1" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "3" "0" "0.983" "0.889" "1.085" "1.034" "0.712" "1.024" "1.038" "0.854" "1.186" "64.3" "63.2" "57.1" "69.8" "66.5" "45.8" "65.8" "66.7" "54.9" "76.2" "" "" "" "" "" "" "" "" "" "" "64.3" "53.5" "36.1" "50.9" "54.4" "35.6" "50.8" "57.4" "42.9" "68.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.000" "False" "10.510" "2" "3" "3" "3" "1490" "163.7" "6.92" "8.22" "3" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "0.992" "0.924" "0.910" "1.044" "0.883" "1.267" "1.062" "0.792" "0.982" "95.9" "95.2" "88.6" "87.3" "100.2" "84.7" "121.6" "101.9" "76.0" "94.2" "" "" "" "" "" "" "" "" "" "" "95.9" "80.5" "56.0" "63.6" "82.1" "65.8" "93.7" "87.6" "59.3" "84.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "10.504" "5" "4" "5" "4" "747" "85.6" "9.23" "13.36" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Gastric cancer network 1" "AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation" "3" "0" "0.972" "0.956" "0.927" "0.994" "0.858" "0.967" "0.981" "0.841" "1.036" "63.4" "61.6" "60.6" "58.8" "63.0" "54.4" "61.3" "62.2" "53.3" "65.7" "" "" "" "" "" "" "" "" "" "" "63.4" "52.1" "38.3" "42.9" "51.6" "42.3" "47.3" "53.5" "41.6" "59.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "10.494" "25" "2" "7" "2" "92" "10.8" "9.44" "19.74" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.191" "1.136" "1.275" "1.106" "1.157" "1.270" "1.118" "1.118" "1.236" "288.6" "343.7" "327.7" "368.0" "319.0" "333.9" "366.5" "322.6" "322.6" "356.7" "" "" "" "" "" "" "" "" "" "" "288.6" "290.8" "207.2" "268.4" "261.4" "259.3" "282.5" "277.4" "251.8" "320.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "10.490" "7" "4" "4" "4" "474" "53.5" "4.50" "12.54" "4" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "0.980" "0.899" "0.974" "1.098" "0.933" "0.992" "1.036" "0.856" "0.995" "92.2" "90.3" "82.9" "89.8" "101.1" "86.0" "91.4" "95.4" "78.9" "91.7" "" "" "" "" "" "" "" "" "" "" "92.2" "76.4" "52.4" "65.4" "82.9" "66.8" "70.5" "82.1" "61.6" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "10.483" "16" "4" "4" "4" "245" "26.4" "6.52" "10.20" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.876" "0.695" "1.506" "1.129" "0.975" "1.121" "0.494" "1.324" "0.971" "18.1" "15.9" "12.6" "27.2" "20.4" "17.6" "20.3" "8.9" "23.9" "17.6" "" "" "" "" "" "" "" "" "" "" "18.1" "13.4" "8.0" "19.9" "16.7" "13.7" "15.6" "7.7" "18.7" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "10.476" "4" "3" "3" "3" "656" "74.5" "5.34" "9.26" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "Metabolism of folate and pterines" "14" "0" "1.060" "0.944" "1.097" "1.010" "0.966" "1.071" "1.042" "1.103" "0.961" "127.5" "135.2" "120.4" "139.9" "128.9" "123.3" "136.7" "132.9" "140.6" "122.6" "" "" "" "" "" "" "" "" "" "" "127.5" "114.4" "76.1" "102.0" "105.6" "95.7" "105.3" "114.2" "109.8" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7283076570857654598" "False" "High" "IsMasterProtein" "Q96F44" "E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2" "0.000" "False" "10.470" "9" "4" "4" "4" "468" "52.7" "5.69" "10.01" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "81559" "ENSG00000154370" "TRIM11" "A6NKE2; B2RB82; B3KUS3; B4DX88; hsa:81559; Q5VSU1; Q8NCA6; Q96F44; Q9C022" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.547" "1.631" "1.379" "1.278" "1.756" "1.638" "1.342" "1.047" "1.533" "11.7" "18.1" "19.1" "16.1" "14.9" "20.5" "19.2" "15.7" "12.2" "17.9" "" "" "" "" "" "" "" "" "" "" "11.7" "15.3" "12.1" "11.8" "12.2" "15.9" "14.8" "13.5" "9.6" "16.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129418023889810362" "False" "High" "IsMasterProtein" "P40429" "Large ribosomal subunit protein uL13 OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2" "0.000" "False" "10.467" "12" "3" "3" "3" "203" "23.6" "10.93" "9.87" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00572" "23521" "ENSG00000142541" "RPL13A" "A8K505; hsa:23521; P40429" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.890" "1.201" "0.939" "1.071" "1.364" "0.899" "1.250" "1.496" "1.046" "184.4" "164.1" "221.4" "173.1" "197.4" "251.4" "165.8" "230.4" "275.8" "192.8" "" "" "" "" "" "" "" "" "" "" "184.4" "138.9" "140.0" "126.2" "161.8" "195.2" "127.8" "198.1" "215.3" "173.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "10.461" "5" "2" "3" "2" "374" "43.2" "6.21" "8.69" "2" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "9" "0" "0.984" "1.160" "1.117" "0.975" "0.908" "1.185" "0.964" "1.017" "1.064" "52.3" "51.4" "60.6" "58.4" "51.0" "47.5" "61.9" "50.4" "53.2" "55.6" "" "" "" "" "" "" "" "" "" "" "52.3" "43.5" "38.3" "42.6" "41.8" "36.9" "47.7" "43.3" "41.5" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "10.456" "17" "2" "3" "2" "127" "14.5" "5.38" "10.07" "2" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "0.869" "0.942" "0.968" "0.922" "0.840" "0.887" "0.942" "0.936" "1.055" "86.5" "75.2" "81.5" "83.7" "79.8" "72.7" "76.7" "81.5" "80.9" "91.2" "" "" "" "" "" "" "" "" "" "" "86.5" "63.6" "51.5" "61.0" "65.4" "56.4" "59.1" "70.0" "63.2" "82.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "10.454" "9" "5" "6" "5" "509" "58.2" "8.62" "15.51" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.201" "1.068" "1.152" "1.247" "1.299" "1.349" "1.001" "1.032" "1.136" "82.7" "99.2" "88.3" "95.2" "103.1" "107.4" "111.5" "82.8" "85.3" "93.9" "" "" "" "" "" "" "" "" "" "" "82.7" "84.0" "55.8" "69.4" "84.5" "83.4" "85.9" "71.2" "66.6" "84.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "147053636108274367" "False" "High" "IsMasterProtein" "Q08AE8" "Protein spire homolog 1 OS=Homo sapiens OX=9606 GN=SPIRE1 PE=1 SV=3" "0.000" "False" "10.452" "4" "3" "3" "3" "756" "85.5" "8.62" "10.51" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf16474" "56907" "ENSG00000134278" "SPIRE1" "A8K2B5; hsa:56907; J3KQ50; J3KQR5; Q08AE8; Q1RMD4; Q8NDP1; Q9NQ71; Q9ULT4" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.931" "0.742" "0.996" "1.104" "0.894" "1.111" "0.963" "0.739" "0.927" "146.1" "136.0" "108.4" "145.5" "161.2" "130.5" "162.3" "140.7" "108.0" "135.4" "" "" "" "" "" "" "" "" "" "" "146.1" "115.1" "68.5" "106.1" "132.1" "101.4" "125.1" "121.0" "84.3" "121.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501773806852137610" "False" "High" "IsMasterProtein" "Q96PN7" "Transcriptional-regulating factor 1 OS=Homo sapiens OX=9606 GN=TRERF1 PE=1 SV=1" "0.000" "False" "10.448" "2" "3" "3" "3" "1200" "132.2" "6.74" "8.20" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448, Pf13912" "55809" "ENSG00000124496" "TRERF1" "hsa:55809; Q05GC6; Q7Z6T2; Q7Z6T3; Q96PN7; Q9NQ72; Q9NQ73; Q9NUN9" "Mesodermal commitment pathway" "" "1" "0" "1.136" "1.119" "1.127" "1.072" "1.187" "1.087" "1.134" "1.115" "1.162" "115.3" "130.9" "129.0" "129.9" "123.6" "136.8" "125.3" "130.7" "128.5" "133.9" "" "" "" "" "" "" "" "" "" "" "115.3" "110.8" "81.5" "94.7" "101.2" "106.3" "96.6" "112.4" "100.3" "120.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6058304427516802646" "False" "High" "IsMasterProtein" "Q7Z6J9" "tRNA-splicing endonuclease subunit Sen54 OS=Homo sapiens OX=9606 GN=TSEN54 PE=1 SV=3" "0.000" "False" "10.440" "7" "3" "3" "3" "526" "58.8" "7.91" "8.72" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12928" "283989" "ENSG00000182173" "TSEN54" "hsa:283989; Q7Z6J9; Q86WV3; Q86XE4; Q8N9H2" "" "tRNA processing in the nucleus" "1" "0" "1.412" "1.084" "1.034" "1.145" "1.167" "1.020" "0.985" "1.117" "1.203" "23.6" "33.3" "25.6" "24.4" "27.0" "27.5" "24.0" "23.2" "26.3" "28.4" "" "" "" "" "" "" "" "" "" "" "23.6" "28.1" "16.2" "17.8" "22.1" "21.4" "18.5" "20.0" "20.5" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "10.423" "18" "2" "3" "2" "96" "11.2" "8.88" "9.55" "2" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "0.925" "0.988" "0.866" "1.006" "1.056" "1.133" "1.024" "1.039" "0.978" "235.9" "218.1" "233.0" "204.4" "237.2" "249.1" "267.3" "241.7" "245.2" "230.8" "" "" "" "" "" "" "" "" "" "" "235.9" "184.5" "147.3" "149.0" "194.4" "193.5" "206.1" "207.8" "191.4" "207.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "10.401" "13" "3" "4" "3" "226" "24.4" "6.10" "12.18" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.999" "0.956" "1.046" "0.992" "1.127" "1.348" "0.935" "0.973" "1.007" "88.4" "88.3" "84.5" "92.4" "87.7" "99.7" "119.1" "82.7" "86.0" "89.0" "" "" "" "" "" "" "" "" "" "" "88.4" "74.7" "53.4" "67.4" "71.9" "77.4" "91.8" "71.1" "67.1" "80.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "10.389" "26" "2" "8" "2" "115" "12.5" "7.88" "21.65" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "6" "0" "1.090" "1.108" "1.000" "0.942" "0.978" "1.071" "0.974" "1.081" "1.181" "256.3" "279.3" "284.1" "256.2" "241.5" "250.6" "274.4" "249.6" "277.2" "302.6" "" "" "" "" "" "" "" "" "" "" "256.3" "236.3" "179.6" "186.8" "197.8" "194.6" "211.5" "214.6" "216.4" "272.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "High" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.000" "False" "10.375" "8" "4" "4" "3" "424" "48.1" "5.63" "12.89" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "66" "1" "0.978" "1.009" "1.024" "1.065" "1.046" "0.997" "1.029" "1.072" "1.077" "277.7" "271.7" "280.1" "284.3" "295.9" "290.5" "276.9" "285.9" "297.7" "299.3" "" "" "" "" "" "" "" "" "" "" "277.7" "229.9" "177.1" "207.3" "242.4" "225.6" "213.4" "245.8" "232.3" "269.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.000" "False" "10.367" "15" "3" "3" "3" "254" "27.7" "4.46" "7.87" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "4" "0" "1.079" "1.313" "1.425" "1.091" "1.088" "0.974" "1.175" "1.099" "1.209" "34.2" "36.9" "45.0" "48.8" "37.4" "37.2" "33.4" "40.2" "37.6" "41.4" "" "" "" "" "" "" "" "" "" "" "34.2" "31.3" "28.4" "35.6" "30.6" "28.9" "25.7" "34.6" "29.4" "37.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "10.356" "10" "3" "3" "3" "278" "29.5" "8.56" "10.10" "3" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "" "Peroxisomal protein import; RA biosynthesis pathway" "2" "0" "1.140" "1.028" "1.053" "1.092" "1.076" "1.105" "1.159" "1.055" "0.956" "279.2" "318.2" "287.1" "294.1" "305.0" "300.5" "308.6" "323.6" "294.4" "267.0" "" "" "" "" "" "" "" "" "" "" "279.2" "269.2" "181.5" "214.4" "249.9" "233.4" "237.9" "278.2" "229.8" "240.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.000" "False" "10.355" "5" "4" "4" "4" "800" "91.1" "7.87" "11.20" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "MAPK signaling pathway" "" "1" "0" "1.073" "0.937" "1.161" "1.246" "1.042" "1.067" "1.091" "1.014" "1.062" "104.1" "111.7" "97.6" "120.9" "129.8" "108.5" "111.1" "113.7" "105.6" "110.6" "" "" "" "" "" "" "" "" "" "" "104.1" "94.5" "61.7" "88.2" "106.3" "84.2" "85.6" "97.7" "82.4" "99.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "10.355" "17" "2" "4" "2" "163" "18.2" "8.82" "14.90" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Novel intracellular components of RIG-I-like receptor pathway" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "6" "0" "1.066" "1.155" "1.147" "0.976" "0.836" "1.194" "1.140" "0.980" "0.968" "93.5" "99.6" "107.9" "107.2" "91.3" "78.1" "111.5" "106.5" "91.6" "90.4" "" "" "" "" "" "" "" "" "" "" "93.5" "84.3" "68.2" "78.2" "74.8" "60.6" "86.0" "91.6" "71.5" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2344420003979128506" "False" "High" "IsMasterProtein" "O60449" "Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75 PE=1 SV=3" "0.000" "False" "10.339" "2" "2" "3" "2" "1722" "198.2" "6.67" "8.92" "2" "stress response;transport;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00040, Pf00059" "100526664; 4065" "ENSG00000054219" "LY75" "hsa:100526664; hsa:4065; O60449; O75913; Q53R46; Q53TF5; Q7Z575; Q7Z577" "" "" "0" "0" "1.005" "0.952" "0.992" "1.215" "1.013" "0.981" "1.083" "1.034" "0.871" "51.9" "52.1" "49.4" "51.4" "63.0" "52.5" "50.9" "56.2" "53.7" "45.2" "" "" "" "" "" "" "" "" "" "" "51.9" "44.1" "31.2" "37.5" "51.6" "40.8" "39.2" "48.3" "41.9" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.000" "False" "10.339" "4" "2" "2" "2" "459" "51.2" "6.54" "7.62" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.995" "0.957" "0.922" "0.988" "1.055" "1.129" "1.029" "0.908" "1.071" "117.3" "116.7" "112.2" "108.2" "115.9" "123.7" "132.5" "120.7" "106.5" "125.6" "" "" "" "" "" "" "" "" "" "" "117.3" "98.7" "70.9" "78.9" "94.9" "96.0" "102.1" "103.8" "83.1" "113.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "10.319" "28" "4" "4" "4" "160" "18.3" "4.88" "11.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "2q11.2 copy number variation syndrome" "" "1" "0" "0.865" "1.018" "1.049" "0.960" "0.999" "1.018" "1.017" "0.866" "0.894" "173.9" "150.5" "177.0" "182.4" "166.9" "173.7" "177.0" "176.8" "150.5" "155.4" "" "" "" "" "" "" "" "" "" "" "173.9" "127.3" "111.9" "133.0" "136.7" "134.9" "136.5" "152.0" "117.5" "139.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3279265676386753137" "False" "High" "IsMasterProtein" "Q9BXB4" "Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2" "0.000" "False" "10.316" "4" "3" "4" "3" "747" "83.6" "7.06" "12.42" "3" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114885" "ENSG00000144909" "OSBPL11" "A8K9I7; hsa:114885; Q9BXB4" "" "RHOH GTPase cycle" "1" "0" "0.986" "0.897" "0.955" "1.056" "0.969" "0.995" "0.998" "0.902" "0.985" "264.5" "260.7" "237.4" "252.5" "279.4" "256.4" "263.1" "264.1" "238.7" "260.6" "" "" "" "" "" "" "" "" "" "" "264.5" "220.5" "150.1" "184.1" "228.9" "199.1" "202.8" "227.0" "186.3" "234.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1474010075378452952" "False" "High" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "0.000" "False" "10.315" "1" "2" "2" "2" "2871" "331.6" "6.81" "7.60" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373, Pf21019" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "Formation of the cornified envelope; Neutrophil degranulation; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "9" "0" "0.350" "0.178" "0.171" "0.150" "0.247" "0.121" "0.141" "0.504" "0.114" "233.8" "81.9" "41.6" "40.0" "35.0" "57.8" "28.3" "32.9" "117.9" "26.7" "" "" "" "" "" "" "" "" "" "" "233.8" "69.3" "26.3" "29.2" "28.7" "44.9" "21.8" "28.3" "92.0" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.000" "False" "10.309" "3" "2" "3" "2" "776" "86.4" "5.87" "14.82" "2" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "1.144" "1.023" "1.109" "1.334" "1.038" "1.224" "1.170" "1.159" "1.176" "52.4" "59.9" "53.6" "58.1" "69.9" "54.4" "64.1" "61.3" "60.8" "61.6" "" "" "" "" "" "" "" "" "" "" "52.4" "50.7" "33.9" "42.4" "57.3" "42.3" "49.4" "52.7" "47.4" "55.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.000" "False" "10.305" "6" "3" "4" "3" "647" "71.9" "6.99" "9.40" "3" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "High" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.000" "False" "10.295" "8" "5" "5" "5" "559" "62.9" "7.36" "13.57" "5" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "" "TBC/RABGAPs" "1" "0" "0.976" "0.951" "1.044" "1.019" "0.993" "1.089" "1.069" "0.999" "1.027" "296.1" "289.0" "281.7" "309.0" "301.6" "294.2" "322.4" "316.5" "295.8" "304.1" "" "" "" "" "" "" "" "" "" "" "296.1" "244.5" "178.1" "225.3" "247.1" "228.4" "248.5" "272.1" "230.9" "273.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7909778503156322818" "False" "High" "IsMasterProtein" "Q96J02" "E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2" "0.000" "False" "10.284" "5" "4" "5" "2" "903" "102.7" "6.30" "12.16" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00397, Pf00632" "83737" "ENSG00000078747" "ITCH" "A6NEW4; B4E234; E1P5P3; F5H217; hsa:83737; O43584; Q5QP37; Q5TEL0; Q96F66; Q96J02; Q9BY75; Q9H451; Q9H4U5" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; 10q11.21q11.23 copy number variation syndrome; Notch signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of necroptotic cell death; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Downregulation of ERBB4 signaling" "16" "0" "1.103" "0.938" "1.067" "1.145" "1.039" "0.929" "1.153" "1.056" "1.144" "86.0" "94.9" "80.7" "91.8" "98.5" "89.4" "79.9" "99.2" "90.8" "98.4" "" "" "" "" "" "" "" "" "" "" "86.0" "80.3" "51.0" "67.0" "80.7" "69.4" "61.6" "85.3" "70.9" "88.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8098039391314381890" "False" "High" "IsMasterProtein" "Q92503" "SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2" "0.000" "False" "10.257" "5" "3" "5" "3" "715" "81.2" "6.43" "15.52" "3" "stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00650, Pf03765, Pf04707" "6397" "ENSG00000129657" "SEC14L1" "A8K4E8; B4DDI5; D5G3K1; hsa:6397; Q92503; Q99780" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "1.120" "0.674" "1.167" "1.082" "0.937" "0.941" "1.132" "0.842" "0.930" "14.2" "15.9" "9.6" "16.6" "15.4" "13.3" "13.4" "16.1" "12.0" "13.2" "" "" "" "" "" "" "" "" "" "" "14.2" "13.5" "6.1" "12.1" "12.6" "10.4" "10.3" "13.9" "9.4" "11.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "10.246" "10" "2" "2" "2" "197" "21.6" "5.45" "9.34" "2" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.996" "1.017" "0.955" "0.867" "0.929" "0.932" "0.919" "0.994" "1.057" "222.9" "221.9" "226.8" "212.9" "193.2" "207.2" "207.7" "204.9" "221.6" "235.7" "" "" "" "" "" "" "" "" "" "" "222.9" "187.8" "143.4" "155.2" "158.3" "160.9" "160.1" "176.2" "172.9" "211.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "10.219" "5" "4" "4" "4" "599" "60.9" "9.33" "12.26" "4" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.084" "0.909" "1.074" "1.112" "1.047" "1.217" "1.241" "0.894" "1.007" "338.8" "367.3" "307.9" "364.0" "376.6" "354.9" "412.3" "420.6" "302.8" "341.1" "" "" "" "" "" "" "" "" "" "" "338.8" "310.7" "194.7" "265.4" "308.6" "275.6" "317.8" "361.6" "236.3" "306.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.000" "False" "10.212" "21" "3" "4" "3" "117" "13.3" "11.47" "10.38" "3" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.951" "1.496" "1.068" "1.097" "1.650" "1.026" "1.498" "1.568" "1.218" "160.6" "152.7" "240.2" "171.6" "176.2" "265.0" "164.8" "240.6" "251.9" "195.6" "" "" "" "" "" "" "" "" "" "" "160.6" "129.2" "151.9" "125.1" "144.4" "205.8" "127.0" "206.9" "196.6" "175.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2760060553440129895" "False" "High" "IsMasterProtein" "Q8NDB2" "B-cell scaffold protein with ankyrin repeats OS=Homo sapiens OX=9606 GN=BANK1 PE=1 SV=3" "0.000" "False" "10.208" "4" "3" "3" "3" "785" "89.2" "5.40" "10.19" "3" "signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "55024" "ENSG00000153064" "BANK1" "A8K7W8; B0F3S2; hsa:55024; Q8N5K8; Q8NB56; Q8NDB2; Q8WYN5; Q9NWP2" "" "" "0" "0" "0.975" "0.951" "1.034" "1.035" "0.919" "1.159" "1.042" "0.856" "0.947" "214.5" "209.1" "204.1" "221.9" "222.0" "197.1" "248.7" "223.5" "183.7" "203.2" "" "" "" "" "" "" "" "" "" "" "214.5" "176.9" "129.0" "161.8" "181.9" "153.0" "191.7" "192.2" "143.4" "182.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "10.208" "19" "3" "3" "3" "184" "20.9" "5.43" "10.53" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "" "Glutathione synthesis and recycling" "1" "0" "0.958" "1.045" "0.869" "0.980" "0.971" "0.970" "0.928" "0.940" "1.048" "135.5" "129.8" "141.6" "117.8" "132.8" "131.6" "131.5" "125.8" "127.3" "142.0" "" "" "" "" "" "" "" "" "" "" "135.5" "109.8" "89.5" "85.9" "108.8" "102.2" "101.3" "108.2" "99.4" "127.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "10.205" "4" "5" "5" "5" "1159" "134.2" "6.98" "13.34" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "1.136" "1.072" "1.087" "1.130" "1.124" "1.103" "1.126" "1.142" "1.061" "397.0" "451.0" "425.7" "431.6" "448.4" "446.1" "437.9" "447.0" "453.2" "421.1" "" "" "" "" "" "" "" "" "" "" "397.0" "381.5" "269.2" "314.7" "367.4" "346.4" "337.6" "384.3" "353.8" "378.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "10.172" "13" "3" "3" "3" "226" "26.5" "5.88" "9.74" "3" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "0.976" "0.965" "0.987" "0.980" "0.893" "1.070" "1.053" "0.913" "1.002" "349.7" "341.2" "337.6" "345.2" "342.6" "312.1" "374.1" "368.2" "319.4" "350.3" "" "" "" "" "" "" "" "" "" "" "349.7" "288.6" "213.5" "251.7" "280.7" "242.4" "288.3" "316.5" "249.3" "315.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "10.160" "23" "3" "3" "3" "119" "13.6" "5.38" "10.43" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Ciliary landscape" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.074" "0.821" "1.062" "1.009" "0.941" "1.293" "1.047" "0.937" "0.921" "239.0" "256.7" "196.3" "253.9" "241.2" "224.9" "309.0" "250.3" "223.9" "220.0" "" "" "" "" "" "" "" "" "" "" "239.0" "217.2" "124.1" "185.1" "197.7" "174.7" "238.2" "215.2" "174.8" "197.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "10.159" "5" "2" "2" "2" "424" "44.3" "8.44" "7.22" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "11" "0" "1.052" "1.039" "1.159" "1.075" "1.032" "1.001" "1.041" "1.057" "0.986" "165.8" "174.5" "172.2" "192.1" "178.3" "171.1" "166.0" "172.6" "175.3" "163.4" "" "" "" "" "" "" "" "" "" "" "165.8" "147.6" "108.9" "140.1" "146.1" "132.9" "128.0" "148.4" "136.8" "146.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.000" "False" "10.151" "8" "1" "2" "1" "144" "16.3" "5.03" "7.53" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "Intraflagellar transport" "6" "0" "0.960" "1.011" "0.983" "0.946" "0.996" "1.059" "1.036" "0.824" "1.117" "137.2" "131.7" "138.7" "134.9" "129.7" "136.6" "145.2" "142.2" "113.1" "153.2" "" "" "" "" "" "" "" "" "" "" "137.2" "111.4" "87.7" "98.4" "106.3" "106.1" "111.9" "122.2" "88.3" "137.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658427898063884792" "False" "High" "IsMasterProtein" "Q9P2N7" "Kelch-like protein 13 OS=Homo sapiens OX=9606 GN=KLHL13 PE=1 SV=3" "0.000" "False" "10.149" "5" "3" "3" "3" "655" "73.8" "6.62" "8.89" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "90293" "ENSG00000003096" "KLHL13" "B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; hsa:90293; Q6P2E3; Q96QI7; Q9P2N7; Q9UDN9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.055" "0.958" "0.967" "1.120" "0.945" "1.041" "1.055" "0.806" "1.000" "116.9" "123.3" "112.1" "113.1" "130.9" "110.5" "121.8" "123.4" "94.2" "116.9" "" "" "" "" "" "" "" "" "" "" "116.9" "104.3" "70.9" "82.5" "107.3" "85.8" "93.9" "106.1" "73.5" "105.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "10.138" "4" "3" "3" "3" "1024" "114.6" "9.22" "10.42" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "" "tRNA processing in the nucleus" "1" "0" "1.096" "0.916" "1.105" "0.994" "1.008" "1.051" "1.017" "1.061" "0.992" "159.2" "174.5" "145.9" "175.9" "158.2" "160.5" "167.4" "162.0" "168.9" "157.9" "" "" "" "" "" "" "" "" "" "" "159.2" "147.6" "92.2" "128.3" "129.6" "124.6" "129.0" "139.3" "131.8" "142.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5405439584537602890" "False" "High" "IsMasterProtein" "Q9BX46" "RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1" "0.000" "False" "10.120" "8" "2" "4" "2" "236" "24.8" "8.51" "9.69" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "221662" "ENSG00000112183" "RBM24" "E9PAY4; hsa:221662; Q6QDA4; Q8N9D3; Q96NI3; Q9BX46" "" "" "0" "0" "1.041" "1.001" "1.182" "1.002" "0.928" "1.147" "1.081" "0.892" "0.946" "186.2" "193.9" "186.3" "220.0" "186.6" "172.7" "213.5" "201.2" "166.1" "176.2" "" "" "" "" "" "" "" "" "" "" "186.2" "164.0" "117.8" "160.4" "152.9" "134.1" "164.6" "173.0" "129.7" "158.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "10.109" "25" "2" "3" "2" "104" "11.9" "9.66" "10.24" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "Mitochondrial complex III assembly" "" "1" "0" "1.074" "1.084" "0.990" "1.081" "0.980" "1.053" "1.255" "1.232" "1.067" "71.2" "76.5" "77.3" "70.5" "77.0" "69.8" "75.0" "89.4" "87.7" "76.0" "" "" "" "" "" "" "" "" "" "" "71.2" "64.7" "48.9" "51.4" "63.1" "54.2" "57.8" "76.9" "68.5" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "10.107" "8" "2" "4" "2" "298" "33.8" "6.44" "15.94" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "10.104" "7" "3" "4" "3" "465" "53.4" "7.02" "12.01" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "" "Interferon gamma signaling" "1" "0" "1.133" "0.840" "1.067" "1.064" "0.999" "1.013" "1.065" "0.884" "0.969" "84.9" "96.1" "71.3" "90.5" "90.3" "84.8" "86.0" "90.4" "75.0" "82.3" "" "" "" "" "" "" "" "" "" "" "84.9" "81.3" "45.1" "66.0" "74.0" "65.8" "66.3" "77.7" "58.5" "74.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "10.102" "4" "2" "2" "1" "598" "64.3" "7.56" "7.14" "2" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "" "Coenzyme A biosynthesis" "1" "0" "0.925" "0.996" "0.975" "1.011" "0.934" "0.940" "1.011" "0.931" "0.931" "139.8" "129.3" "139.3" "136.4" "141.3" "130.6" "131.5" "141.3" "130.1" "130.1" "" "" "" "" "" "" "" "" "" "" "139.8" "109.4" "88.1" "99.4" "115.8" "101.4" "101.3" "121.5" "101.5" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6070529034068729651" "False" "High" "IsMasterProtein" "Q8TEV9" "Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2" "0.000" "False" "10.099" "2" "2" "4" "2" "937" "105.0" "5.58" "8.78" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11704" "140775" "ENSG00000176994; ENSG00000283741" "SMCR8" "A5PKZ5; hsa:140775; Q3ZCN0; Q6PJL3; Q8TEV9" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.000" "False" "10.095" "11" "3" "3" "3" "301" "34.2" "7.59" "10.26" "3" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Oxidation by cytochrome P450" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "4" "0" "1.187" "1.291" "1.102" "1.152" "1.225" "1.119" "1.260" "1.357" "1.179" "191.4" "227.1" "247.0" "210.9" "220.5" "234.5" "214.2" "241.1" "259.7" "225.7" "" "" "" "" "" "" "" "" "" "" "191.4" "192.2" "156.2" "153.7" "180.6" "182.1" "165.1" "207.3" "202.7" "202.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1870630596764229112" "False" "High" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0.000" "False" "10.094" "2" "4" "4" "4" "1979" "227.4" "5.26" "11.26" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "" "Intraflagellar transport; Intra-Golgi traffic; Signaling by FLT3 fusion proteins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "10.093" "33" "3" "5" "2" "79" "9.9" "8.46" "16.30" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "Small cell lung cancer" "" "1" "1" "0.847" "0.793" "0.908" "0.997" "0.828" "1.021" "0.956" "0.738" "0.905" "438.5" "371.5" "347.6" "398.2" "437.2" "363.0" "447.8" "419.4" "323.6" "397.0" "" "" "" "" "" "" "" "" "" "" "438.5" "314.3" "219.8" "290.3" "358.2" "281.9" "345.2" "360.6" "252.6" "356.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "10.043" "8" "3" "3" "3" "392" "43.1" "6.29" "9.26" "3" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Primary ovarian insufficiency" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.088" "1.168" "1.303" "1.169" "1.083" "1.060" "1.036" "1.188" "1.228" "61.5" "67.0" "71.9" "80.2" "71.9" "66.6" "65.2" "63.8" "73.1" "75.5" "" "" "" "" "" "" "" "" "" "" "61.5" "56.6" "45.4" "58.4" "58.9" "51.8" "50.3" "54.8" "57.1" "67.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "10.042" "7" "2" "3" "2" "309" "33.4" "5.77" "10.62" "2" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "0.877" "1.061" "0.979" "1.025" "0.972" "1.033" "1.063" "1.110" "1.051" "128.6" "112.8" "136.4" "125.9" "131.8" "125.0" "132.9" "136.8" "142.7" "135.2" "" "" "" "" "" "" "" "" "" "" "128.6" "95.5" "86.3" "91.8" "108.0" "97.1" "102.4" "117.6" "111.4" "121.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "10.034" "10" "3" "5" "3" "243" "27.9" "4.20" "14.72" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "Protein hydroxylation" "1" "0" "0.956" "0.975" "1.015" "1.036" "0.952" "1.036" "0.938" "0.905" "1.004" "246.1" "235.3" "239.9" "249.8" "255.1" "234.3" "254.9" "230.9" "222.8" "247.1" "" "" "" "" "" "" "" "" "" "" "246.1" "199.1" "151.7" "182.2" "209.0" "182.0" "196.5" "198.6" "173.9" "222.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "High" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.000" "False" "10.027" "8" "2" "5" "2" "258" "29.4" "9.38" "16.10" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.022" "1.010" "0.925" "1.014" "0.919" "0.980" "1.072" "0.906" "0.985" "246.3" "251.7" "248.8" "227.9" "249.8" "226.2" "241.4" "263.9" "223.2" "242.6" "" "" "" "" "" "" "" "" "" "" "246.3" "212.9" "157.3" "166.2" "204.7" "175.7" "186.1" "226.9" "174.2" "218.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "High" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.000" "False" "10.007" "4" "3" "3" "3" "644" "72.7" "4.87" "9.37" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "1.014" "0.774" "0.930" "0.995" "0.664" "0.900" "1.010" "0.760" "0.733" "88.0" "89.3" "68.1" "81.9" "87.6" "58.4" "79.2" "88.9" "66.9" "64.5" "" "" "" "" "" "" "" "" "" "" "88.0" "75.5" "43.1" "59.7" "71.8" "45.4" "61.1" "76.5" "52.2" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "10.000" "3" "3" "3" "3" "1025" "117.3" "5.73" "8.73" "3" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "3" "0" "0.998" "0.957" "1.202" "1.181" "1.179" "1.077" "0.967" "1.122" "1.178" "71.4" "71.3" "68.3" "85.8" "84.3" "84.2" "76.9" "69.0" "80.1" "84.1" "" "" "" "" "" "" "" "" "" "" "71.4" "60.3" "43.2" "62.6" "69.1" "65.4" "59.3" "59.4" "62.5" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5661386699023188299" "False" "High" "IsMasterProtein" "Q9Y4B4" "Helicase ARIP4 OS=Homo sapiens OX=9606 GN=RAD54L2 PE=1 SV=4" "0.000" "False" "9.998" "2" "3" "5" "3" "1467" "162.7" "6.09" "15.06" "3" "cell organization and biogenesis" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "23132" "ENSG00000164080" "RAD54L2" "hsa:23132; Q8TB57; Q9BV54; Q9Y4B4" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "1.039" "0.714" "1.248" "1.024" "0.852" "1.229" "1.093" "0.811" "0.888" "161.7" "167.9" "115.5" "201.8" "165.6" "137.7" "198.8" "176.7" "131.1" "143.6" "" "" "" "" "" "" "" "" "" "" "161.7" "142.1" "73.0" "147.1" "135.7" "106.9" "153.2" "151.9" "102.4" "129.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "9.995" "10" "2" "2" "2" "307" "33.9" "6.29" "8.96" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "0.852" "1.012" "0.985" "0.846" "0.766" "1.003" "1.000" "1.139" "1.046" "43.7" "37.2" "44.2" "43.0" "36.9" "33.5" "43.8" "43.7" "49.7" "45.7" "" "" "" "" "" "" "" "" "" "" "43.7" "31.5" "27.9" "31.4" "30.3" "26.0" "33.7" "37.5" "38.8" "41.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4534983152498971383" "False" "High" "IsMasterProtein" "Q8N4C6" "Ninein OS=Homo sapiens OX=9606 GN=NIN PE=1 SV=4" "0.000" "False" "9.984" "1" "2" "2" "2" "2090" "243.1" "5.03" "7.54" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "51199" "ENSG00000100503" "NIN" "A6NDB8; B7WPA3; C9JSB6; C9JSG2; C9JXL2; hsa:51199; Q5BKU3; Q6P0P6; Q8N4C6; Q9BWU6; Q9C012; Q9C013; Q9C014; Q9H5I6; Q9HAT7; Q9HBY5; Q9HCK7; Q9UH61" "" "" "0" "0" "1.170" "0.799" "1.112" "1.105" "1.010" "1.323" "1.311" "0.893" "0.967" "50.6" "59.3" "40.5" "56.3" "56.0" "51.2" "67.0" "66.4" "45.2" "49.0" "" "" "" "" "" "" "" "" "" "" "50.6" "50.1" "25.6" "41.1" "45.9" "39.7" "51.6" "57.1" "35.3" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7857168411920132290" "False" "High" "IsMasterProtein" "Q9Y5B8" "Nucleoside diphosphate kinase homolog 7 OS=Homo sapiens OX=9606 GN=NME7 PE=1 SV=1" "0.000" "False" "9.983" "10" "4" "4" "4" "376" "42.5" "6.47" "9.14" "4" "other metabolic processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00334" "29922" "ENSG00000143156" "NME7" "A8K3T6; A8MY09; B3KSW9; hsa:29922; Q5TGZ4; Q9Y5B8" "Pyrimidine metabolism; Ciliopathies" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.063" "0.931" "1.135" "1.044" "0.913" "1.028" "0.985" "0.895" "0.968" "384.7" "409.1" "358.2" "436.6" "401.6" "351.2" "395.5" "378.8" "344.4" "372.3" "" "" "" "" "" "" "" "" "" "" "384.7" "346.1" "226.5" "318.3" "329.1" "272.7" "304.9" "325.7" "268.8" "334.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "258971474423548673" "False" "High" "IsMasterProtein" "Q14746" "Conserved oligomeric Golgi complex subunit 2 OS=Homo sapiens OX=9606 GN=COG2 PE=1 SV=1" "0.000" "False" "9.965" "4" "3" "3" "3" "738" "83.2" "6.62" "9.94" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf06148, Pf12022" "22796" "ENSG00000135775" "COG2" "hsa:22796; Q14746; Q86U99" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "1.035" "0.852" "0.845" "0.947" "0.985" "1.002" "1.035" "0.805" "0.905" "130.9" "135.5" "111.5" "110.6" "124.0" "129.0" "131.2" "135.5" "105.4" "118.5" "" "" "" "" "" "" "" "" "" "" "130.9" "114.6" "70.5" "80.7" "101.6" "100.1" "101.1" "116.5" "82.3" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "9.959" "9" "3" "4" "3" "426" "46.0" "8.53" "8.72" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "5" "0" "1.070" "1.068" "1.168" "1.150" "1.110" "1.116" "1.058" "1.124" "1.165" "209.8" "224.4" "224.0" "245.0" "241.4" "232.9" "234.0" "222.0" "235.9" "244.3" "" "" "" "" "" "" "" "" "" "" "209.8" "189.8" "141.6" "178.7" "197.8" "180.9" "180.4" "190.9" "184.1" "219.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "9.956" "7" "4" "4" "4" "456" "50.4" "8.16" "12.41" "4" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Regulation of signaling by CBL; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "5" "0" "0.981" "1.036" "1.035" "1.005" "0.931" "0.999" "1.002" "0.916" "0.911" "403.8" "396.2" "418.4" "417.8" "405.8" "376.0" "403.3" "404.5" "370.1" "368.1" "" "" "" "" "" "" "" "" "" "" "403.8" "335.2" "264.6" "304.7" "332.4" "292.0" "310.9" "347.8" "288.8" "330.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4122795445893117169" "False" "High" "IsMasterProtein" "Q16548" "Bcl-2-related protein A1 OS=Homo sapiens OX=9606 GN=BCL2A1 PE=1 SV=1" "0.000" "False" "9.955" "15" "2" "2" "2" "175" "20.1" "5.38" "5.61" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf00452" "597" "ENSG00000140379" "BCL2A1" "hsa:597; Q16548; Q6FGZ4; Q6FH19; Q86W13; Q99524" "Photodynamic therapy-induced HIF-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; Acute myeloid leukemia" "Nuclear events stimulated by ALK signaling in cancer" "5" "0" "0.996" "0.937" "1.106" "0.981" "0.927" "1.235" "1.161" "0.936" "1.045" "91.8" "91.4" "86.0" "101.5" "90.1" "85.2" "113.4" "106.7" "85.9" "95.9" "" "" "" "" "" "" "" "" "" "" "91.8" "77.4" "54.4" "74.0" "73.8" "66.1" "87.4" "91.7" "67.1" "86.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.000" "False" "9.954" "6" "1" "2" "1" "204" "22.4" "5.83" "7.82" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "" "HATs acetylate histones" "1" "0" "1.324" "0.760" "1.094" "1.471" "1.098" "0.958" "1.035" "0.998" "1.121" "12.0" "15.8" "9.1" "13.1" "17.6" "13.1" "11.5" "12.4" "11.9" "13.4" "" "" "" "" "" "" "" "" "" "" "12.0" "13.4" "5.7" "9.5" "14.4" "10.2" "8.8" "10.6" "9.3" "12.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "9.951" "19" "3" "4" "3" "167" "18.8" "8.95" "13.00" "3" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "1.196" "0.971" "1.059" "1.217" "1.161" "1.291" "1.107" "1.070" "0.992" "212.8" "254.4" "206.6" "225.3" "259.0" "247.0" "274.6" "235.6" "227.7" "211.1" "" "" "" "" "" "" "" "" "" "" "212.8" "215.3" "130.6" "164.3" "212.2" "191.8" "211.7" "202.6" "177.7" "189.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741603039625968059" "False" "High" "IsMasterProtein" "Q96T49" "Protein phosphatase 1 regulatory inhibitor subunit 16B OS=Homo sapiens OX=9606 GN=PPP1R16B PE=1 SV=1" "0.000" "False" "9.944" "5" "3" "3" "3" "567" "63.5" "6.49" "8.75" "3" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity" "Pf00023, Pf12796" "26051" "ENSG00000101445" "PPP1R16B" "A2RRR6; E9PFS8; hsa:26051; O94912; Q5W9G4; Q96T49; Q9NQG4" "" "" "0" "0" "0.990" "1.059" "1.029" "0.965" "1.001" "1.012" "0.868" "1.053" "0.971" "45.1" "44.7" "47.8" "46.4" "43.5" "45.2" "45.7" "39.2" "47.5" "43.8" "" "" "" "" "" "" "" "" "" "" "45.1" "37.8" "30.2" "33.9" "35.7" "35.1" "35.2" "33.7" "37.1" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "9.939" "8" "3" "3" "3" "323" "37.6" "7.15" "10.19" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "39" "0" "0.973" "0.929" "1.005" "1.045" "0.956" "1.037" "1.049" "0.969" "1.008" "193.7" "188.4" "179.9" "194.6" "202.4" "185.1" "200.8" "203.2" "187.7" "195.3" "" "" "" "" "" "" "" "" "" "" "193.7" "159.4" "113.8" "141.9" "165.8" "143.7" "154.8" "174.7" "146.5" "175.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "9.930" "4" "3" "3" "1" "766" "86.6" "8.72" "10.36" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "" "3" "0" "1.078" "0.992" "1.000" "0.985" "0.971" "0.958" "1.008" "0.921" "0.871" "115.3" "124.3" "114.3" "115.2" "113.5" "111.9" "110.4" "116.2" "106.1" "100.4" "" "" "" "" "" "" "" "" "" "" "115.3" "105.2" "72.3" "84.0" "93.0" "86.9" "85.1" "99.9" "82.8" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847516572355730355" "False" "High" "IsMasterProtein" "P46020" "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=PHKA1 PE=1 SV=2" "0.000" "False" "9.928" "2" "3" "3" "3" "1223" "137.2" "6.19" "9.48" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5255" "ENSG00000067177" "PHKA1" "B7ZL05; B7ZL07; hsa:5255; P46020; Q2M3D7" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.988" "0.996" "1.128" "1.113" "0.792" "1.190" "1.288" "0.968" "1.092" "100.7" "99.5" "100.3" "113.6" "112.1" "79.7" "119.9" "129.6" "97.4" "109.9" "" "" "" "" "" "" "" "" "" "" "100.7" "84.2" "63.4" "82.8" "91.8" "61.9" "92.4" "111.5" "76.0" "98.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6341136208215643454" "False" "High" "IsMasterProtein" "Q6GYQ0" "Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1" "0.000" "False" "9.923" "1" "3" "3" "3" "2036" "229.7" "6.19" "9.06" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "253959" "ENSG00000174373" "RALGAPA1" "A6NMA4; B9EK38; C5NU19; hsa:253959; O94960; Q6GYP9; Q6GYQ0; Q6ZT23; Q86YF3; Q86YF5; Q8ND69" "" "RHOH GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "9.923" "3" "2" "2" "2" "735" "84.7" "6.34" "7.02" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "Ciliary landscape" "" "1" "0" "1.056" "0.896" "1.145" "1.073" "0.949" "1.051" "1.039" "0.905" "1.066" "74.2" "78.3" "66.5" "84.9" "79.6" "70.4" "77.9" "77.1" "67.2" "79.1" "" "" "" "" "" "" "" "" "" "" "74.2" "66.3" "42.0" "61.9" "65.2" "54.7" "60.1" "66.3" "52.4" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "9.918" "4" "2" "3" "2" "620" "67.2" "6.77" "10.47" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "Ciliary landscape" "MET activates RAS signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "9.908" "5" "4" "5" "4" "650" "73.9" "4.88" "13.44" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "" "3" "0" "1.184" "1.071" "0.941" "1.047" "1.191" "1.146" "1.162" "1.125" "1.128" "135.1" "160.0" "144.6" "127.1" "141.3" "160.8" "154.8" "157.0" "151.9" "152.4" "" "" "" "" "" "" "" "" "" "" "135.1" "135.3" "91.4" "92.7" "115.8" "124.9" "119.3" "135.0" "118.6" "137.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "9.903" "7" "1" "3" "1" "181" "20.4" "5.72" "8.37" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.054" "0.958" "1.482" "0.874" "1.075" "1.342" "1.081" "1.014" "0.879" "39.6" "41.7" "37.9" "58.7" "34.6" "42.5" "53.1" "42.8" "40.1" "34.8" "" "" "" "" "" "" "" "" "" "" "39.6" "35.3" "24.0" "42.8" "28.3" "33.0" "40.9" "36.8" "31.3" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "9.902" "22" "3" "6" "3" "118" "12.7" "7.30" "15.37" "3" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "1.025" "1.096" "1.141" "1.066" "1.114" "1.076" "1.116" "1.091" "1.224" "529.7" "543.0" "580.4" "604.4" "564.8" "590.2" "569.8" "590.9" "577.9" "648.3" "" "" "" "" "" "" "" "" "" "" "529.7" "459.4" "367.0" "440.7" "462.7" "458.3" "439.2" "508.0" "451.1" "582.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "9.897" "9" "4" "4" "4" "352" "40.2" "5.47" "11.67" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "2" "0" "1.052" "0.900" "1.019" "0.996" "0.973" "1.016" "1.040" "1.006" "1.037" "202.5" "212.9" "182.2" "206.4" "201.6" "197.1" "205.8" "210.5" "203.8" "210.0" "" "" "" "" "" "" "" "" "" "" "202.5" "180.2" "115.2" "150.5" "165.2" "153.1" "158.6" "181.0" "159.0" "188.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "9.886" "5" "4" "4" "4" "721" "79.1" "6.70" "11.20" "4" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Mesodermal commitment pathway" "Signaling by ALK fusions and activated point mutants" "2" "0" "0.997" "0.961" "1.138" "1.246" "1.119" "1.207" "1.116" "0.958" "1.153" "103.1" "102.7" "99.0" "117.4" "128.5" "115.4" "124.4" "115.1" "98.8" "118.9" "" "" "" "" "" "" "" "" "" "" "103.1" "86.9" "62.6" "85.6" "105.3" "89.6" "95.9" "99.0" "77.1" "106.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758554991952715701" "False" "High" "IsMasterProtein" "Q9C0F1" "Centrosomal protein of 44 kDa OS=Homo sapiens OX=9606 GN=CEP44 PE=1 SV=2" "0.000" "False" "9.845" "9" "3" "3" "3" "390" "44.1" "5.21" "9.32" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf15007" "80817" "ENSG00000164118" "CEP44" "A8K8W9; A8MW11; B3KT53; D3DP42; hsa:80817; Q8IXZ4; Q9C0F1" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "0.912" "1.077" "1.015" "1.137" "0.792" "1.047" "1.177" "0.815" "1.239" "31.4" "28.6" "33.8" "31.9" "35.7" "24.9" "32.9" "37.0" "25.6" "38.9" "" "" "" "" "" "" "" "" "" "" "31.4" "24.2" "21.4" "23.2" "29.3" "19.3" "25.3" "31.8" "20.0" "35.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781498784979718201" "False" "High" "IsMasterProtein" "Q8IY22" "C-Maf-inducing protein OS=Homo sapiens OX=9606 GN=CMIP PE=1 SV=3" "0.000" "False" "9.836" "3" "3" "3" "3" "773" "86.3" "6.70" "8.97" "3" "developmental processes" "cytosol;nucleus" "" "" "80790" "ENSG00000153815" "CMIP" "hsa:80790; Q8IY22; Q9C0G9" "" "" "0" "0" "1.000" "0.853" "1.023" "0.990" "0.816" "1.042" "1.070" "0.856" "0.941" "288.7" "288.8" "246.2" "295.3" "285.8" "235.7" "300.9" "308.9" "247.0" "271.6" "" "" "" "" "" "" "" "" "" "" "288.7" "244.3" "155.7" "215.3" "234.1" "183.0" "232.0" "265.6" "192.8" "244.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "9.829" "19" "3" "5" "3" "127" "14.1" "9.03" "14.98" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.032" "0.903" "0.899" "0.956" "0.821" "0.833" "0.849" "0.921" "0.947" "534.0" "551.0" "482.0" "480.0" "510.2" "438.4" "444.6" "453.5" "492.0" "505.4" "" "" "" "" "" "" "" "" "" "" "534.0" "466.2" "304.8" "350.0" "418.0" "340.4" "342.7" "389.9" "384.0" "454.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "9.812" "8" "2" "3" "2" "211" "23.3" "5.01" "10.49" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "Insulin signaling" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "13" "0" "0.851" "0.892" "0.989" "0.972" "0.913" "1.161" "0.973" "0.826" "0.990" "170.0" "144.6" "151.6" "168.0" "165.1" "155.1" "197.3" "165.4" "140.3" "168.2" "" "" "" "" "" "" "" "" "" "" "170.0" "122.3" "95.9" "122.5" "135.3" "120.5" "152.1" "142.2" "109.5" "151.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4201705345580193530" "False" "High" "IsMasterProtein" "Q969F9" "BLOC-2 complex member HPS3 OS=Homo sapiens OX=9606 GN=HPS3 PE=1 SV=1" "0.000" "False" "9.810" "4" "3" "3" "3" "1004" "113.7" "6.43" "9.39" "3" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle;other cell component" "" "Pf14761, Pf14763" "84343" "ENSG00000163755" "HPS3" "A8K6G6; hsa:84343; Q8WTV6; Q969F9; Q96AP1; Q96MR3; Q9H608" "" "" "0" "0" "1.210" "0.932" "1.155" "1.053" "0.812" "1.187" "1.206" "0.939" "1.071" "30.9" "37.4" "28.8" "35.7" "32.5" "25.1" "36.6" "37.2" "29.0" "33.0" "" "" "" "" "" "" "" "" "" "" "30.9" "31.6" "18.2" "26.0" "26.6" "19.5" "28.2" "32.0" "22.6" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3846544257037738653" "False" "High" "IsMasterProtein" "Q96RT7" "Gamma-tubulin complex component 6 OS=Homo sapiens OX=9606 GN=TUBGCP6 PE=1 SV=3" "0.000" "False" "9.796" "2" "2" "2" "2" "1819" "200.4" "6.32" "6.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681, Pf19340" "85378" "ENSG00000128159" "TUBGCP6" "hsa:85378; Q5JZ80; Q6PJ40; Q86YE9; Q96RT7; Q9BY91; Q9UGX3; Q9UGX4" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "0.979" "1.124" "1.059" "1.137" "1.229" "1.261" "1.028" "1.110" "1.049" "48.5" "47.5" "54.5" "51.3" "55.1" "59.6" "61.1" "49.8" "53.8" "50.8" "" "" "" "" "" "" "" "" "" "" "48.5" "40.2" "34.5" "37.4" "45.1" "46.3" "47.1" "42.9" "42.0" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "9.796" "22" "4" "7" "1" "143" "15.1" "10.74" "19.36" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; RMTs methylate histone arginines; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "47" "3" "1.129" "1.095" "1.027" "1.158" "1.039" "1.126" "0.991" "1.247" "1.075" "408.8" "461.5" "447.6" "419.7" "473.6" "424.8" "460.2" "405.3" "509.8" "439.6" "" "" "" "" "" "" "" "" "" "" "408.8" "390.4" "283.0" "306.1" "388.0" "329.9" "354.7" "348.5" "397.9" "395.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "9.792" "18" "2" "3" "2" "119" "13.3" "11.56" "8.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA processing" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "5" "0" "0.954" "0.965" "1.247" "1.119" "1.169" "1.145" "0.795" "1.434" "1.331" "166.1" "158.5" "160.2" "207.1" "185.8" "194.2" "190.1" "132.0" "238.2" "221.1" "" "" "" "" "" "" "" "" "" "" "166.1" "134.1" "101.3" "151.0" "152.3" "150.8" "146.5" "113.5" "186.0" "198.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "9.792" "22" "4" "5" "4" "156" "18.0" "8.21" "12.94" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "mRNA processing; 3q29 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.032" "1.217" "1.029" "1.116" "1.188" "1.053" "1.160" "1.149" "1.111" "192.0" "198.2" "233.7" "197.5" "214.3" "228.1" "202.1" "222.8" "220.7" "213.3" "" "" "" "" "" "" "" "" "" "" "192.0" "167.7" "147.7" "144.0" "175.6" "177.2" "155.8" "191.5" "172.2" "191.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "9.785" "19" "3" "4" "2" "130" "14.4" "9.11" "14.40" "3" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "0" "1.050" "1.065" "1.054" "1.108" "1.178" "1.141" "1.106" "1.116" "1.087" "323.6" "339.6" "344.6" "341.1" "358.4" "381.0" "369.3" "357.9" "361.2" "351.8" "" "" "" "" "" "" "" "" "" "" "323.6" "287.3" "217.9" "248.7" "293.6" "295.9" "284.6" "307.7" "282.0" "316.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "9.778" "3" "3" "4" "1" "897" "101.3" "5.01" "8.40" "3" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4914593963434688361" "False" "High" "IsMasterProtein" "Q6P3X3" "Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1" "0.000" "False" "9.778" "5" "5" "5" "5" "843" "96.6" "5.59" "13.02" "5" "" "" "" "Pf07719" "55622" "ENSG00000018699" "TTC27" "A6NKJ0; hsa:55622; Q6P3X3; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4" "" "" "0" "0" "1.092" "0.968" "1.187" "1.105" "0.954" "1.002" "0.995" "0.900" "1.000" "122.3" "133.6" "118.4" "145.2" "135.2" "116.8" "122.6" "121.7" "110.2" "122.3" "" "" "" "" "" "" "" "" "" "" "122.3" "113.1" "74.9" "105.9" "110.8" "90.7" "94.5" "104.7" "86.0" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264991097181317635" "False" "High" "IsMasterProtein" "Q9NPF5" "DNA methyltransferase 1-associated protein 1 OS=Homo sapiens OX=9606 GN=DMAP1 PE=1 SV=1" "0.000" "False" "9.768" "9" "4" "4" "4" "467" "53.0" "9.50" "8.75" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05499, Pf16282" "55929" "ENSG00000178028" "DMAP1" "A8K001; D3DPY8; hsa:55929; Q0JSM4; Q5TG41; Q7Z3H7; Q9H0S8; Q9NPF5; Q9P2C2" "" "HATs acetylate histones" "1" "0" "0.959" "0.855" "0.833" "1.037" "0.905" "1.133" "0.935" "0.788" "1.023" "141.9" "136.0" "121.3" "118.1" "147.1" "128.4" "160.7" "132.7" "111.8" "145.2" "" "" "" "" "" "" "" "" "" "" "141.9" "115.1" "76.7" "86.1" "120.5" "99.7" "123.9" "114.1" "87.3" "130.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1483529755144940188" "False" "High" "IsMasterProtein" "P78324" "Tyrosine-protein phosphatase non-receptor type substrate 1 OS=Homo sapiens OX=9606 GN=SIRPA PE=1 SV=2" "0.000" "False" "9.767" "4" "2" "2" "2" "504" "54.9" "6.98" "7.58" "2" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf07654, Pf07686" "140885" "ENSG00000198053" "SIRPA" "A2A2E1; A8K411; B2R6C3; hsa:140885; O00683; O43799; P78324; Q8N517; Q8TAL8; Q9H0Z2; Q9UDX2; Q9UIJ6; Q9Y4U9" "Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "7" "0" "1.052" "1.017" "1.221" "1.142" "1.021" "1.156" "1.151" "1.173" "1.078" "194.7" "204.8" "198.1" "237.7" "222.3" "198.7" "225.0" "224.1" "228.4" "209.8" "" "" "" "" "" "" "" "" "" "" "194.7" "173.2" "125.2" "173.4" "182.2" "154.3" "173.5" "192.6" "178.2" "188.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-822484129541956869" "False" "High" "IsMasterProtein" "Q14149" "MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3" "0.000" "False" "9.763" "4" "3" "3" "3" "939" "107.0" "5.60" "9.45" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07496, Pf13589, Pf17942" "23515" "ENSG00000159256" "MORC3" "A8KA92; hsa:23515; Q14149; Q9UEZ2" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.099" "0.899" "1.350" "0.935" "1.031" "1.495" "1.277" "0.969" "1.211" "26.4" "29.0" "23.7" "35.6" "24.6" "27.2" "39.4" "33.7" "25.5" "31.9" "" "" "" "" "" "" "" "" "" "" "26.4" "24.5" "15.0" "25.9" "20.2" "21.1" "30.4" "28.9" "19.9" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.000" "False" "9.749" "5" "2" "2" "2" "409" "43.7" "6.70" "7.63" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.006" "1.051" "0.981" "1.207" "1.019" "1.101" "1.148" "1.207" "1.116" "114.3" "115.0" "120.2" "112.1" "137.9" "116.5" "125.9" "131.2" "137.9" "127.6" "" "" "" "" "" "" "" "" "" "" "114.3" "97.3" "76.0" "81.7" "113.0" "90.5" "97.0" "112.8" "107.7" "114.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "9.749" "7" "4" "5" "4" "546" "64.4" "10.54" "12.90" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7798556211851200264" "False" "High" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "0.000" "False" "9.747" "5" "4" "4" "4" "596" "67.6" "6.96" "12.04" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "Q547V4; Q96AX1; Q9H5Q0" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "4" "0" "1.093" "0.898" "1.073" "1.127" "0.858" "1.015" "1.038" "0.973" "0.974" "162.4" "177.5" "145.8" "174.3" "183.1" "139.4" "164.8" "168.7" "158.0" "158.1" "" "" "" "" "" "" "" "" "" "" "162.4" "150.2" "92.2" "127.1" "150.0" "108.2" "127.1" "145.0" "123.4" "142.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "9.746" "8" "2" "4" "2" "350" "41.2" "8.56" "12.26" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "1.213" "1.129" "0.934" "1.227" "1.170" "1.073" "1.294" "1.232" "1.131" "40.6" "49.3" "45.8" "37.9" "49.8" "47.5" "43.5" "52.5" "50.0" "45.9" "" "" "" "" "" "" "" "" "" "" "40.6" "41.7" "29.0" "27.7" "40.8" "36.9" "33.6" "45.2" "39.0" "41.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "9.731" "6" "4" "5" "4" "564" "62.3" "6.99" "11.61" "4" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "Coenzyme A biosynthesis" "2" "0" "1.061" "1.154" "1.311" "1.188" "1.088" "1.138" "1.212" "1.083" "1.156" "133.2" "141.4" "153.6" "174.6" "158.2" "145.0" "151.5" "161.4" "144.3" "153.9" "" "" "" "" "" "" "" "" "" "" "133.2" "119.6" "97.2" "127.3" "129.6" "112.6" "116.8" "138.8" "112.6" "138.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "9.712" "4" "2" "2" "2" "600" "67.6" "8.06" "7.81" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.958" "0.938" "1.040" "0.916" "0.964" "1.032" "0.928" "0.915" "0.886" "219.1" "209.8" "205.6" "227.9" "200.6" "211.1" "226.1" "203.4" "200.6" "194.1" "" "" "" "" "" "" "" "" "" "" "219.1" "177.5" "130.0" "166.2" "164.4" "164.0" "174.3" "174.9" "156.6" "174.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "809495191273134722" "False" "High" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "0.000" "False" "9.702" "1" "3" "3" "3" "2102" "236.7" "7.06" "9.69" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "4" "0" "1.120" "1.130" "1.102" "1.076" "1.235" "1.407" "1.191" "1.035" "0.953" "71.3" "79.8" "80.5" "78.5" "76.7" "88.0" "100.3" "84.9" "73.8" "67.9" "" "" "" "" "" "" "" "" "" "" "71.3" "67.5" "50.9" "57.3" "62.9" "68.4" "77.3" "73.0" "57.6" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "9.682" "6" "1" "3" "1" "184" "20.7" "7.99" "10.46" "1" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.024" "1.152" "0.947" "1.214" "0.861" "0.978" "1.200" "0.996" "0.984" "80.8" "82.7" "93.1" "76.5" "98.1" "69.5" "79.0" "96.9" "80.5" "79.5" "" "" "" "" "" "" "" "" "" "" "80.8" "70.0" "58.9" "55.8" "80.4" "54.0" "60.9" "83.3" "62.8" "71.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "9.682" "1" "1" "2" "1" "956" "106.8" "5.94" "9.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "Nanoparticle triggered autophagic cell death" "" "1" "0" "1.021" "0.880" "1.092" "1.038" "0.974" "1.107" "1.056" "0.811" "1.032" "106.3" "108.5" "93.6" "116.1" "110.3" "103.5" "117.7" "112.2" "86.2" "109.7" "" "" "" "" "" "" "" "" "" "" "106.3" "91.8" "59.2" "84.6" "90.4" "80.4" "90.7" "96.5" "67.3" "98.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "9.656" "7" "4" "4" "4" "501" "55.7" "8.05" "10.87" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "0.910" "1.184" "1.141" "1.033" "0.994" "1.062" "1.047" "1.170" "0.987" "74.9" "68.2" "88.7" "85.5" "77.4" "74.4" "79.6" "78.5" "87.6" "73.9" "" "" "" "" "" "" "" "" "" "" "74.9" "57.7" "56.1" "62.3" "63.4" "57.8" "61.3" "67.5" "68.4" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "9.654" "20" "2" "2" "2" "137" "14.5" "8.68" "7.91" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "" "Threonine catabolism" "1" "0" "1.008" "1.119" "0.816" "0.976" "1.092" "1.006" "0.951" "1.054" "1.095" "192.8" "194.3" "215.7" "157.2" "188.3" "210.6" "194.0" "183.4" "203.2" "211.2" "" "" "" "" "" "" "" "" "" "" "192.8" "164.4" "136.4" "114.7" "154.2" "163.6" "149.6" "157.7" "158.6" "189.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "High" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.000" "False" "9.650" "6" "3" "3" "3" "476" "52.8" "6.29" "8.25" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "" "3" "0" "0.926" "0.915" "1.033" "1.106" "0.874" "1.219" "1.154" "0.785" "0.927" "162.6" "150.6" "148.8" "167.9" "179.9" "142.2" "198.3" "187.8" "127.6" "150.8" "" "" "" "" "" "" "" "" "" "" "162.6" "127.4" "94.1" "122.5" "147.4" "110.4" "152.8" "161.4" "99.6" "135.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "9.647" "9" "3" "3" "3" "412" "44.5" "6.54" "10.70" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "MHC class II antigen presentation; Neutrophil degranulation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "8" "0" "0.947" "1.081" "0.978" "0.934" "1.003" "0.935" "0.964" "1.069" "0.996" "270.8" "256.5" "292.9" "265.0" "253.0" "271.6" "253.2" "261.0" "289.4" "269.6" "" "" "" "" "" "" "" "" "" "" "270.8" "217.0" "185.2" "193.2" "207.3" "210.9" "195.2" "224.4" "225.9" "242.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "9.641" "15" "4" "6" "4" "221" "25.5" "11.85" "16.72" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "7" "0" "1.005" "1.376" "0.961" "1.108" "1.430" "1.139" "1.096" "1.335" "1.142" "344.1" "345.8" "473.4" "330.5" "381.1" "492.0" "391.7" "377.1" "459.2" "392.9" "" "" "" "" "" "" "" "" "" "" "344.1" "292.5" "299.3" "241.0" "312.3" "382.1" "302.0" "324.2" "358.5" "353.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "9.639" "6" "3" "3" "3" "570" "61.8" "6.11" "9.58" "3" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "1.033" "0.727" "0.888" "0.926" "0.948" "0.831" "0.881" "0.752" "0.971" "79.5" "82.1" "57.8" "70.6" "73.6" "75.3" "66.0" "70.0" "59.8" "77.2" "" "" "" "" "" "" "" "" "" "" "79.5" "69.4" "36.5" "51.5" "60.3" "58.5" "50.9" "60.2" "46.7" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "9.638" "7" "4" "4" "4" "425" "47.6" "6.62" "10.99" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.099" "1.227" "0.993" "1.009" "1.114" "1.045" "1.091" "1.142" "1.211" "245.0" "269.2" "300.6" "243.2" "247.3" "272.8" "256.0" "267.2" "279.8" "296.7" "" "" "" "" "" "" "" "" "" "" "245.0" "227.7" "190.0" "177.3" "202.6" "211.9" "197.3" "229.8" "218.4" "266.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.000" "False" "9.637" "3" "6" "6" "6" "1812" "201.9" "5.01" "14.71" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "0.898" "1.361" "1.071" "0.909" "1.129" "1.061" "1.004" "1.266" "1.072" "160.7" "144.3" "218.7" "172.1" "146.1" "181.5" "170.6" "161.4" "203.5" "172.3" "" "" "" "" "" "" "" "" "" "" "160.7" "122.0" "138.3" "125.5" "119.7" "141.0" "131.5" "138.7" "158.8" "154.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436526655011241506" "False" "High" "IsMasterProtein" "P19793" "Retinoic acid receptor RXR-alpha OS=Homo sapiens OX=9606 GN=RXRA PE=1 SV=1" "0.000" "False" "9.631" "6" "3" "4" "1" "462" "50.8" "7.80" "11.78" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf11825" "6256" "ENSG00000186350" "RXRA" "B3KY83; hsa:6256; P19793; Q2NL52; Q2V504" "Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; Kleefstra syndrome; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors; Cytoprotection by HMOX1; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.000" "False" "9.626" "3" "3" "3" "3" "941" "107.8" "7.05" "8.96" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "2" "0" "1.095" "0.967" "1.004" "1.012" "0.996" "1.087" "1.075" "0.893" "1.138" "134.0" "146.8" "129.6" "134.6" "135.7" "133.5" "145.7" "144.1" "119.7" "152.6" "" "" "" "" "" "" "" "" "" "" "134.0" "124.2" "82.0" "98.2" "111.1" "103.7" "112.3" "123.9" "93.4" "137.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.000" "False" "9.618" "8" "3" "3" "3" "349" "37.2" "8.25" "10.07" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.120" "0.739" "1.093" "1.029" "0.912" "1.091" "0.982" "0.856" "1.070" "261.6" "293.0" "193.4" "286.1" "269.2" "238.5" "285.4" "257.0" "223.9" "279.8" "" "" "" "" "" "" "" "" "" "" "261.6" "247.9" "122.3" "208.6" "220.5" "185.3" "220.0" "221.0" "174.8" "251.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "9.617" "11" "3" "4" "3" "277" "31.3" "5.15" "7.91" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.966" "0.757" "1.200" "1.140" "0.661" "1.122" "1.062" "0.830" "0.943" "184.9" "178.7" "140.0" "221.9" "210.8" "122.3" "207.5" "196.5" "153.5" "174.4" "" "" "" "" "" "" "" "" "" "" "184.9" "151.2" "88.6" "161.8" "172.7" "95.0" "159.9" "168.9" "119.8" "156.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "9.613" "8" "4" "4" "4" "370" "41.5" "8.18" "12.39" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.895" "0.875" "0.885" "0.858" "0.922" "0.835" "0.885" "0.923" "0.923" "594.4" "532.2" "520.3" "525.9" "509.8" "548.0" "496.3" "526.1" "548.9" "548.7" "" "" "" "" "" "" "" "" "" "" "594.4" "450.3" "329.0" "383.5" "417.7" "425.5" "382.6" "452.3" "428.4" "493.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "9.611" "8" "3" "3" "3" "429" "46.7" "8.62" "10.07" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.077" "1.047" "1.077" "1.076" "1.011" "1.072" "1.062" "0.946" "0.982" "237.8" "256.1" "248.9" "256.0" "255.8" "240.3" "254.8" "252.6" "225.0" "233.5" "" "" "" "" "" "" "" "" "" "" "237.8" "216.7" "157.4" "186.7" "209.6" "186.6" "196.4" "217.2" "175.7" "209.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "9.604" "8" "2" "2" "2" "233" "26.2" "5.74" "7.48" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "9.599" "8" "3" "3" "3" "292" "33.5" "9.50" "10.33" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Cytoplasmic ribosomal proteins" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.062" "0.997" "0.980" "1.028" "1.045" "0.963" "1.019" "0.936" "1.084" "362.6" "385.2" "361.4" "355.1" "372.9" "379.1" "349.1" "369.6" "339.5" "393.0" "" "" "" "" "" "" "" "" "" "" "362.6" "325.9" "228.5" "259.0" "305.5" "294.4" "269.1" "317.8" "265.0" "353.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "9.598" "11" "2" "4" "2" "204" "23.4" "5.49" "12.70" "2" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.059" "0.869" "0.938" "1.065" "1.052" "1.047" "1.087" "0.903" "1.088" "125.6" "133.0" "109.1" "117.8" "133.7" "132.1" "131.5" "136.4" "113.4" "136.7" "" "" "" "" "" "" "" "" "" "" "125.6" "112.6" "69.0" "85.9" "109.5" "102.6" "101.4" "117.3" "88.5" "122.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2903433267102321467" "False" "High" "IsMasterProtein" "Q9UL03" "Integrator complex subunit 6 OS=Homo sapiens OX=9606 GN=INTS6 PE=1 SV=1" "0.000" "False" "9.584" "4" "4" "4" "4" "887" "100.3" "8.62" "11.05" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf13519, Pf15300" "26512" "ENSG00000102786" "INTS6" "hsa:26512; Q0P664; Q6PJP4; Q9UFK0; Q9UL03; Q9Y5M9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.817" "0.903" "0.845" "0.964" "0.853" "0.964" "0.928" "0.873" "0.988" "142.6" "116.5" "128.8" "120.6" "137.4" "121.6" "137.5" "132.4" "124.5" "141.0" "" "" "" "" "" "" "" "" "" "" "142.6" "98.6" "81.4" "87.9" "112.6" "94.4" "106.0" "113.9" "97.2" "126.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "9.580" "1" "4" "4" "4" "3056" "350.5" "6.81" "9.85" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Regulation of HSF1-mediated heat shock response; Resolution of D-loop Structures through Holliday Junction Intermediates; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks; Pexophagy" "54" "0" "1.048" "0.845" "1.092" "0.964" "0.867" "1.114" "1.143" "0.660" "0.822" "41.5" "43.5" "35.1" "45.3" "40.0" "36.0" "46.2" "47.4" "27.4" "34.1" "" "" "" "" "" "" "" "" "" "" "41.5" "36.8" "22.2" "33.0" "32.8" "27.9" "35.6" "40.8" "21.4" "30.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5612646896286873908" "False" "High" "IsMasterProtein" "Q6PJG2" "Mitotic deacetylase-associated SANT domain protein OS=Homo sapiens OX=9606 GN=MIDEAS PE=1 SV=2" "0.000" "False" "9.573" "2" "2" "2" "2" "1045" "114.9" "9.19" "7.59" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448" "91748" "ENSG00000156030" "MIDEAS" "hsa:91748; Q6PJG2; Q6PK13; Q6PK59; Q6ZS23" "" "" "0" "0" "1.217" "0.964" "1.114" "1.121" "1.005" "1.260" "1.341" "0.996" "1.161" "86.4" "105.2" "83.3" "96.2" "96.9" "86.9" "108.9" "115.9" "86.0" "100.3" "" "" "" "" "" "" "" "" "" "" "86.4" "89.0" "52.7" "70.2" "79.4" "67.5" "84.0" "99.6" "67.2" "90.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6355678057945092611" "False" "High" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "0.000" "False" "9.571" "2" "3" "3" "3" "1498" "168.8" "7.50" "8.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "" "Condensation of Prophase Chromosomes" "1" "0" "1.649" "1.496" "1.466" "1.529" "1.018" "1.152" "1.599" "1.231" "1.200" "26.3" "43.3" "39.3" "38.5" "40.2" "26.7" "30.3" "42.0" "32.3" "31.5" "" "" "" "" "" "" "" "" "" "" "26.3" "36.6" "24.8" "28.1" "32.9" "20.8" "23.3" "36.1" "25.2" "28.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8069107240958525203" "False" "High" "IsMasterProtein" "Q92993" "Histone acetyltransferase KAT5 OS=Homo sapiens OX=9606 GN=KAT5 PE=1 SV=2" "0.000" "False" "9.570" "7" "4" "4" "4" "513" "58.5" "8.48" "7.86" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "10524" "ENSG00000172977" "KAT5" "B4E3C7; C9JL99; hsa:10524; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q92993; Q9BWK7" "Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; HDAC6 interactions in the central nervous system" "Estrogen-dependent gene expression; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cardiogenesis; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "9.558" "3" "1" "1" "1" "362" "41.8" "4.86" "4.48" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "1.112" "0.940" "1.034" "1.032" "0.807" "0.984" "0.936" "0.803" "0.973" "100.3" "111.5" "94.3" "103.8" "103.5" "81.0" "98.7" "93.9" "80.6" "97.6" "" "" "" "" "" "" "" "" "" "" "100.3" "94.4" "59.6" "75.7" "84.8" "62.9" "76.1" "80.8" "62.9" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "9.557" "7" "3" "3" "3" "442" "50.5" "5.63" "9.33" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "" "Potential therapeutics for SARS" "1" "0" "1.041" "1.033" "0.937" "0.943" "1.012" "0.966" "1.014" "1.105" "1.112" "186.8" "194.4" "193.0" "175.0" "176.3" "189.1" "180.6" "189.5" "206.4" "207.8" "" "" "" "" "" "" "" "" "" "" "186.8" "164.5" "122.0" "127.6" "144.4" "146.9" "139.2" "162.9" "161.1" "186.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "9.547" "2" "4" "6" "3" "2024" "228.4" "5.02" "15.44" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "9.544" "8" "2" "2" "2" "362" "39.3" "5.52" "7.74" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Metapathway biotransformation Phase I and II" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "0.864" "0.962" "1.140" "0.976" "1.012" "0.899" "0.969" "0.790" "0.985" "38.2" "33.0" "36.7" "43.5" "37.3" "38.6" "34.3" "37.0" "30.1" "37.6" "" "" "" "" "" "" "" "" "" "" "38.2" "27.9" "23.2" "31.7" "30.5" "30.0" "26.5" "31.8" "23.5" "33.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3071770870623054181" "False" "High" "IsMasterProtein" "Q8N442" "Translation factor GUF1, mitochondrial OS=Homo sapiens OX=9606 GN=GUF1 PE=1 SV=1" "0.000" "False" "9.524" "4" "3" "4" "3" "669" "74.3" "8.59" "10.96" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "translation activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf06421" "60558" "ENSG00000151806" "GUF1" "hsa:60558; Q5XKM8; Q8N442; Q9H710; Q9H8U4" "" "" "0" "0" "3.081" "1.098" "1.907" "1.837" "1.726" "1.665" "1.235" "1.699" "1.663" "41.7" "128.6" "45.8" "79.6" "76.7" "72.0" "69.5" "51.5" "70.9" "69.4" "" "" "" "" "" "" "" "" "" "" "41.7" "108.8" "29.0" "58.0" "62.8" "55.9" "53.6" "44.3" "55.3" "62.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "9.520" "5" "4" "5" "4" "753" "80.7" "8.09" "12.27" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "0.956" "0.753" "0.978" "0.951" "0.789" "0.922" "0.964" "0.784" "0.825" "157.8" "150.8" "118.9" "154.3" "150.0" "124.4" "145.5" "152.1" "123.8" "130.2" "" "" "" "" "" "" "" "" "" "" "157.8" "127.6" "75.2" "112.5" "122.9" "96.6" "112.2" "130.8" "96.6" "117.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2764493771843335681" "False" "High" "IsMasterProtein" "P08651" "Nuclear factor 1 C-type OS=Homo sapiens OX=9606 GN=NFIC PE=1 SV=2" "0.000" "False" "9.517" "6" "3" "3" "3" "508" "55.6" "8.38" "9.51" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4782" "ENSG00000141905" "NFIC" "A8K1H0; B7Z4U5; B7Z9C3; hsa:4782; K7EMU1; P08651; P08652; Q14932; Q9UPJ3; Q9UPJ9; Q9UPK0; Q9UPK1" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "1.127" "1.122" "1.122" "1.076" "1.151" "1.091" "1.116" "1.204" "0.978" "231.8" "261.3" "260.2" "260.0" "249.4" "266.8" "252.9" "258.6" "279.1" "226.7" "" "" "" "" "" "" "" "" "" "" "231.8" "221.1" "164.5" "189.6" "204.3" "207.2" "194.9" "222.4" "217.9" "203.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "9.516" "27" "3" "3" "3" "136" "15.1" "5.05" "5.69" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4366826834122666967" "False" "High" "IsMasterProtein" "Q92966" "snRNA-activating protein complex subunit 3 OS=Homo sapiens OX=9606 GN=SNAPC3 PE=1 SV=1" "0.000" "False" "9.510" "8" "3" "3" "3" "411" "46.7" "5.27" "8.68" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12251" "6619" "ENSG00000164975" "SNAPC3" "D3DRI8; hsa:6619; Q2VPI6; Q5T285; Q92966" "" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "3" "0" "0.850" "0.770" "0.924" "0.993" "0.747" "0.987" "0.840" "0.666" "0.925" "83.3" "70.8" "64.1" "76.9" "82.7" "62.2" "82.2" "69.9" "55.5" "77.0" "" "" "" "" "" "" "" "" "" "" "83.3" "59.9" "40.5" "56.1" "67.8" "48.3" "63.4" "60.1" "43.3" "69.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "9.497" "40" "3" "3" "3" "99" "10.9" "9.57" "9.68" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "1.128" "0.911" "1.178" "1.180" "0.935" "1.122" "1.125" "0.964" "0.943" "173.3" "195.5" "157.9" "204.2" "204.4" "161.9" "194.5" "195.0" "167.0" "163.5" "" "" "" "" "" "" "" "" "" "" "173.3" "165.4" "99.9" "148.9" "167.5" "125.8" "149.9" "167.6" "130.4" "147.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "9.497" "4" "2" "2" "2" "508" "55.0" "7.06" "8.51" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "EGF/EGFR signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle" "8" "0" "0.922" "0.829" "0.927" "1.001" "0.811" "0.953" "0.894" "0.809" "1.027" "112.3" "103.5" "93.1" "104.1" "112.4" "91.0" "107.0" "100.3" "90.8" "115.3" "" "" "" "" "" "" "" "" "" "" "112.3" "87.5" "58.9" "75.9" "92.1" "70.7" "82.5" "86.2" "70.9" "103.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.000" "False" "9.486" "3" "3" "3" "3" "1035" "119.0" "6.05" "9.09" "3" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "" "Ub-specific processing proteases" "1" "0" "0.886" "0.945" "1.021" "0.963" "0.923" "0.913" "0.992" "0.887" "1.027" "139.4" "123.5" "131.7" "142.3" "134.3" "128.6" "127.3" "138.2" "123.6" "143.1" "" "" "" "" "" "" "" "" "" "" "139.4" "104.5" "83.3" "103.7" "110.0" "99.9" "98.1" "118.8" "96.5" "128.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "9.482" "12" "3" "5" "3" "275" "29.6" "8.10" "14.95" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.109" "1.088" "1.096" "1.086" "1.035" "0.973" "1.093" "1.250" "1.199" "114.5" "127.0" "124.6" "125.5" "124.4" "118.5" "111.5" "125.1" "143.2" "137.3" "" "" "" "" "" "" "" "" "" "" "114.5" "107.5" "78.8" "91.5" "101.9" "92.0" "85.9" "107.6" "111.7" "123.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.000" "False" "9.479" "9" "2" "2" "2" "234" "26.1" "6.24" "7.44" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "0.968" "0.837" "1.037" "0.943" "0.758" "0.940" "0.988" "0.914" "0.876" "368.0" "356.1" "307.9" "381.7" "347.1" "278.8" "345.9" "363.4" "336.2" "322.4" "" "" "" "" "" "" "" "" "" "" "368.0" "301.2" "194.7" "278.3" "284.4" "216.5" "266.7" "312.4" "262.4" "289.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "9.470" "8" "4" "5" "4" "372" "41.9" "7.31" "15.59" "4" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "" "GDP-fucose biosynthesis" "1" "0" "1.040" "1.082" "1.045" "1.030" "1.038" "1.122" "1.009" "1.029" "1.064" "225.1" "234.0" "243.6" "235.2" "231.8" "233.6" "252.6" "227.1" "231.5" "239.5" "" "" "" "" "" "" "" "" "" "" "225.1" "198.0" "154.0" "171.5" "189.9" "181.4" "194.7" "195.3" "180.7" "215.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "9.455" "6" "3" "4" "3" "505" "58.2" "5.22" "12.55" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "FTO obesity variant mechanism" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "1.004" "1.054" "0.984" "1.085" "1.125" "1.035" "1.023" "1.084" "1.015" "134.7" "135.2" "142.0" "132.6" "146.2" "151.5" "139.4" "137.8" "146.0" "136.7" "" "" "" "" "" "" "" "" "" "" "134.7" "114.4" "89.8" "96.7" "119.8" "117.7" "107.4" "118.5" "114.0" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "9.455" "4" "2" "3" "2" "596" "68.2" "5.85" "9.54" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "15" "0" "0.850" "0.868" "1.312" "1.106" "0.815" "1.068" "1.188" "0.814" "0.920" "45.9" "39.1" "39.9" "60.3" "50.8" "37.5" "49.1" "54.6" "37.4" "42.3" "" "" "" "" "" "" "" "" "" "" "45.9" "33.1" "25.2" "44.0" "41.6" "29.1" "37.8" "46.9" "29.2" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "9.453" "16" "3" "3" "3" "200" "22.2" "4.68" "10.42" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.035" "1.086" "1.314" "1.028" "1.015" "1.285" "1.162" "1.095" "1.252" "135.7" "140.4" "147.3" "178.3" "139.4" "137.6" "174.3" "157.6" "148.5" "169.8" "" "" "" "" "" "" "" "" "" "" "135.7" "118.8" "93.2" "130.0" "114.2" "106.9" "134.3" "135.5" "115.9" "152.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "9.446" "5" "2" "2" "2" "483" "51.7" "8.00" "7.41" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "0" "0.845" "0.815" "0.874" "0.966" "0.865" "0.878" "0.891" "0.758" "0.975" "158.8" "134.2" "129.5" "138.8" "153.3" "137.4" "139.5" "141.5" "120.4" "154.8" "" "" "" "" "" "" "" "" "" "" "158.8" "113.5" "81.9" "101.2" "125.6" "106.7" "107.5" "121.6" "94.0" "139.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "9.445" "7" "2" "2" "2" "275" "32.4" "5.77" "6.45" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Negative regulators of DDX58/IFIH1 signaling; Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "13" "0" "0.854" "1.097" "1.006" "0.967" "0.877" "0.881" "1.169" "0.911" "1.253" "36.8" "31.5" "40.4" "37.1" "35.6" "32.3" "32.4" "43.1" "33.6" "46.1" "" "" "" "" "" "" "" "" "" "" "36.8" "26.6" "25.6" "27.0" "29.2" "25.1" "25.0" "37.0" "26.2" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "9.444" "2" "2" "2" "2" "1068" "119.3" "6.67" "7.46" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "5q35 copy number variation" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "3" "0" "1.215" "1.238" "1.077" "1.392" "1.299" "1.062" "1.210" "1.346" "1.188" "107.4" "130.5" "133.0" "115.7" "149.5" "139.5" "114.1" "129.9" "144.6" "127.6" "" "" "" "" "" "" "" "" "" "" "107.4" "110.4" "84.1" "84.4" "122.5" "108.3" "87.9" "111.7" "112.8" "114.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2683396977362819782" "False" "High" "IsMasterProtein" "P17931" "Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5" "0.000" "False" "9.439" "12" "3" "3" "3" "250" "26.1" "8.56" "9.18" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00337" "3958" "ENSG00000131981" "LGALS3" "B2RC38; hsa:3958; P17931; Q16005; Q6IBA7; Q96J47" "AGE/RAGE pathway; Spinal cord injury; 2q13 copy number variation syndrome; Immune infiltration in pancreatic cancer" "Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells" "8" "0" "0.849" "1.121" "1.038" "1.135" "1.253" "1.040" "1.030" "1.134" "1.209" "124.1" "105.3" "139.1" "128.9" "140.8" "155.4" "129.1" "127.8" "140.7" "150.0" "" "" "" "" "" "" "" "" "" "" "124.1" "89.1" "87.9" "94.0" "115.4" "120.7" "99.5" "109.9" "109.8" "134.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "9.432" "7" "3" "4" "3" "441" "49.4" "9.91" "11.23" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.869" "0.766" "0.973" "0.939" "0.717" "0.963" "1.136" "0.851" "0.831" "88.0" "76.5" "67.4" "85.7" "82.6" "63.2" "84.8" "100.0" "74.9" "73.2" "" "" "" "" "" "" "" "" "" "" "88.0" "64.7" "42.6" "62.5" "67.7" "49.0" "65.3" "86.0" "58.5" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "9.431" "5" "2" "2" "2" "362" "41.4" "9.28" "7.32" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones" "2" "0" "0.947" "0.795" "0.872" "0.925" "0.815" "0.845" "0.869" "0.752" "0.858" "259.2" "245.4" "206.0" "226.0" "239.8" "211.4" "219.0" "225.2" "194.9" "222.5" "" "" "" "" "" "" "" "" "" "" "259.2" "207.6" "130.2" "164.8" "196.5" "164.1" "168.8" "193.6" "152.1" "200.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "9.426" "18" "4" "4" "4" "175" "20.0" "10.11" "9.75" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.016" "1.174" "0.958" "1.097" "1.035" "1.034" "0.992" "1.158" "1.107" "111.6" "113.3" "130.9" "106.9" "122.3" "115.4" "115.3" "110.6" "129.2" "123.5" "" "" "" "" "" "" "" "" "" "" "111.6" "95.9" "82.8" "77.9" "100.2" "89.6" "88.9" "95.1" "100.8" "111.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "High" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.000" "False" "9.424" "3" "3" "3" "3" "889" "96.8" "6.96" "10.19" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.035" "0.982" "1.146" "1.077" "0.984" "1.123" "1.137" "1.021" "1.012" "221.5" "229.2" "217.5" "253.8" "238.6" "218.0" "248.7" "251.9" "226.1" "224.0" "" "" "" "" "" "" "" "" "" "" "221.5" "193.9" "137.6" "185.0" "195.5" "169.3" "191.7" "216.6" "176.5" "201.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6638571290352112575" "False" "High" "IsMasterProtein" "O00746" "Nucleoside diphosphate kinase, mitochondrial OS=Homo sapiens OX=9606 GN=NME4 PE=1 SV=1" "0.000" "False" "9.419" "18" "2" "2" "2" "187" "20.6" "10.29" "6.87" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4833" "ENSG00000103202" "NME4" "A2IDD0; hsa:4833; O00746; Q5U0M9" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.045" "1.035" "1.060" "0.988" "1.009" "0.936" "0.923" "1.227" "1.092" "54.5" "56.9" "56.4" "57.7" "53.8" "54.9" "51.0" "50.3" "66.8" "59.4" "" "" "" "" "" "" "" "" "" "" "54.5" "48.1" "35.6" "42.1" "44.1" "42.7" "39.3" "43.2" "52.2" "53.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "9.418" "19" "2" "2" "2" "128" "14.2" "8.46" "7.43" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA processing" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "1.077" "1.213" "1.201" "1.046" "1.191" "1.007" "1.089" "1.197" "0.972" "129.6" "139.6" "157.2" "155.6" "135.5" "154.4" "130.4" "141.1" "155.1" "125.9" "" "" "" "" "" "" "" "" "" "" "129.6" "118.1" "99.4" "113.5" "111.0" "119.9" "100.5" "121.3" "121.0" "113.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.000" "False" "9.387" "3" "2" "2" "2" "904" "102.3" "11.84" "8.01" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "1.051" "1.179" "1.151" "1.138" "1.268" "1.138" "1.102" "1.222" "1.107" "206.2" "216.7" "243.1" "237.4" "234.5" "261.4" "234.7" "227.2" "251.9" "228.3" "" "" "" "" "" "" "" "" "" "" "206.2" "183.3" "153.7" "173.1" "192.2" "203.0" "180.9" "195.3" "196.6" "205.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "9.379" "6" "3" "3" "3" "458" "50.3" "6.10" "9.48" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "0.956" "1.091" "1.203" "1.036" "1.068" "1.108" "1.080" "1.109" "1.142" "117.3" "112.2" "128.0" "141.1" "121.6" "125.3" "130.1" "126.8" "130.2" "134.0" "" "" "" "" "" "" "" "" "" "" "117.3" "94.9" "80.9" "102.9" "99.6" "97.3" "100.3" "109.0" "101.6" "120.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "9.374" "13" "3" "5" "3" "224" "24.8" "4.94" "15.77" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "1.119" "0.911" "1.028" "1.049" "0.932" "1.159" "1.168" "0.979" "1.020" "183.5" "205.4" "167.2" "188.6" "192.5" "171.0" "212.8" "214.5" "179.7" "187.3" "" "" "" "" "" "" "" "" "" "" "183.5" "173.8" "105.7" "137.5" "157.7" "132.8" "164.0" "184.4" "140.3" "168.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1988329424413395185" "False" "High" "IsMasterProtein" "Q8WVK7" "Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1" "0.000" "False" "9.366" "9" "1" "2" "1" "121" "14.2" "7.33" "7.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf16740" "348235" "ENSG00000182628" "SKA2" "A6NIL3; B3KPL3; E9PCB8; hsa:348235; Q8WVK7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.040" "0.634" "0.988" "1.169" "0.766" "1.031" "1.054" "0.646" "0.909" "77.8" "80.9" "49.3" "76.9" "90.9" "59.6" "80.2" "82.0" "50.2" "70.7" "" "" "" "" "" "" "" "" "" "" "77.8" "68.5" "31.2" "56.0" "74.5" "46.3" "61.8" "70.5" "39.2" "63.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5902665754527388004" "False" "High" "IsMasterProtein" "Q969R8" "KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1" "0.000" "False" "9.353" "8" "3" "3" "3" "447" "49.3" "5.22" "8.65" "3" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf15907" "55846" "ENSG00000111203" "ITFG2" "A8K4Z5; D3DUQ2; hsa:55846; Q6PKU5; Q969R8; Q96SX6" "" "Amino acids regulate mTORC1" "1" "0" "1.017" "1.050" "1.028" "0.979" "0.914" "1.009" "1.092" "1.044" "1.119" "115.4" "117.3" "121.1" "118.6" "113.0" "105.5" "116.4" "126.0" "120.4" "129.1" "" "" "" "" "" "" "" "" "" "" "115.4" "99.3" "76.6" "86.4" "92.6" "81.9" "89.7" "108.3" "94.0" "116.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "9.350" "16" "4" "5" "4" "199" "22.1" "8.10" "12.04" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "0.903" "1.044" "1.108" "1.071" "1.261" "0.974" "1.059" "1.126" "1.223" "104.5" "94.4" "109.0" "115.7" "111.9" "131.7" "101.8" "110.7" "117.7" "127.8" "" "" "" "" "" "" "" "" "" "" "104.5" "79.8" "69.0" "84.4" "91.7" "102.3" "78.5" "95.1" "91.8" "114.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "9.342" "8" "4" "4" "2" "400" "45.5" "8.68" "12.01" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "Oxidative Stress Induced Senescence; Regulation of TNFR1 signaling; activated TAK1 mediates p38 MAPK activation; VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "9.337" "12" "4" "4" "4" "364" "40.6" "6.48" "11.04" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "" "HATs acetylate histones" "1" "0" "1.067" "0.892" "1.062" "1.147" "0.814" "1.035" "1.069" "0.954" "1.148" "65.7" "70.0" "58.6" "69.7" "75.3" "53.5" "68.0" "70.2" "62.6" "75.4" "" "" "" "" "" "" "" "" "" "" "65.7" "59.3" "37.0" "50.8" "61.7" "41.5" "52.4" "60.3" "48.9" "67.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "High" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.000" "False" "9.323" "11" "2" "3" "2" "221" "25.4" "5.54" "8.43" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "6" "0" "1.120" "0.982" "1.274" "1.091" "0.974" "1.425" "1.120" "0.984" "1.356" "45.1" "50.5" "44.3" "57.5" "49.2" "43.9" "64.3" "50.5" "44.4" "61.2" "" "" "" "" "" "" "" "" "" "" "45.1" "42.7" "28.0" "41.9" "40.3" "34.1" "49.6" "43.4" "34.7" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "9.312" "5" "2" "2" "2" "387" "44.1" "6.16" "6.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.131" "1.248" "1.104" "1.095" "1.093" "1.270" "1.104" "1.310" "1.250" "59.2" "67.0" "73.9" "65.4" "64.9" "64.7" "75.2" "65.4" "77.6" "74.0" "" "" "" "" "" "" "" "" "" "" "59.2" "56.7" "46.7" "47.7" "53.1" "50.2" "58.0" "56.2" "60.5" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.000" "False" "9.303" "5" "3" "3" "3" "739" "78.5" "9.23" "10.46" "3" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "2" "0" "1.105" "0.680" "1.123" "1.181" "0.951" "1.191" "1.022" "0.984" "1.077" "114.2" "126.2" "77.6" "128.2" "134.9" "108.5" "136.0" "116.6" "112.4" "123.0" "" "" "" "" "" "" "" "" "" "" "114.2" "106.7" "49.1" "93.5" "110.5" "84.3" "104.8" "100.3" "87.7" "110.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743572851164951841" "False" "High" "IsMasterProtein" "Q13472" "DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1" "0.000" "False" "9.295" "3" "3" "3" "3" "1001" "112.3" "8.34" "8.22" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01396, Pf01751, Pf06839" "7156" "ENSG00000177302; ENSG00000284238" "TOP3A" "A8KA61; B4DK80; D3DXC7; hsa:7156; Q13472; Q13473" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "16" "0" "0.850" "0.802" "1.017" "1.261" "0.887" "1.023" "1.172" "0.997" "1.062" "25.9" "22.0" "20.7" "26.3" "32.6" "22.9" "26.4" "30.3" "25.8" "27.5" "" "" "" "" "" "" "" "" "" "" "25.9" "18.6" "13.1" "19.2" "26.7" "17.8" "20.4" "26.0" "20.1" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "9.290" "9" "2" "3" "2" "205" "22.3" "5.17" "8.60" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "" "Signaling by NODAL; Signaling by Activin" "2" "0" "1.098" "1.078" "1.086" "0.965" "0.942" "0.970" "0.924" "0.980" "0.931" "228.9" "251.4" "246.8" "248.6" "220.8" "215.6" "222.0" "211.6" "224.3" "213.1" "" "" "" "" "" "" "" "" "" "" "228.9" "212.7" "156.0" "181.3" "180.9" "167.4" "171.1" "181.9" "175.1" "191.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "9.283" "6" "3" "3" "3" "491" "56.9" "7.02" "9.96" "3" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "16p11.2 distal deletion syndrome" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "3" "0" "1.115" "0.964" "1.097" "1.042" "0.954" "1.075" "0.982" "1.078" "1.064" "75.7" "84.4" "72.9" "83.0" "78.9" "72.2" "81.3" "74.3" "81.6" "80.5" "" "" "" "" "" "" "" "" "" "" "75.7" "71.4" "46.1" "60.5" "64.6" "56.0" "62.7" "63.9" "63.7" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "High" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.000" "False" "9.271" "4" "3" "4" "3" "608" "67.4" "7.12" "11.89" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "9.267" "6" "2" "3" "2" "362" "40.9" "5.10" "13.95" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Oxidative damage response" "Nonhomologous End-Joining (NHEJ)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8656179388413657305" "False" "High" "IsMasterProtein" "O00308" "NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2" "0.000" "False" "9.264" "4" "3" "3" "2" "870" "98.9" "7.12" "10.12" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00397, Pf00632" "11060" "ENSG00000198373" "WWP2" "A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6" "" "RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle" "5" "0" "1.262" "1.081" "1.215" "1.146" "1.433" "1.175" "1.137" "1.245" "1.100" "102.3" "129.2" "110.6" "124.4" "117.3" "146.6" "120.3" "116.4" "127.4" "112.6" "" "" "" "" "" "" "" "" "" "" "102.3" "109.3" "69.9" "90.7" "96.1" "113.9" "92.7" "100.0" "99.5" "101.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933297728605715540" "False" "High" "IsMasterProtein" "Q9UIK4" "Death-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=DAPK2 PE=1 SV=1" "0.000" "False" "9.261" "5" "2" "2" "2" "370" "42.9" "6.92" "7.90" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "23604" "ENSG00000035664" "DAPK2" "E9JGM7; hsa:23604; O75892; Q24JS1; Q9UIK4" "Bladder cancer; 7q11.23 distal copy number variation" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "1.133" "0.802" "1.156" "1.001" "0.841" "1.044" "0.996" "0.843" "0.989" "125.8" "142.5" "100.9" "145.5" "125.9" "105.9" "131.4" "125.4" "106.1" "124.5" "" "" "" "" "" "" "" "" "" "" "125.8" "120.6" "63.8" "106.1" "103.2" "82.2" "101.3" "107.8" "82.8" "111.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "9.214" "6" "1" "5" "1" "166" "18.4" "8.29" "13.66" "1" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Oxidative stress response" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "3" "0" "0.908" "1.077" "1.028" "1.004" "1.058" "1.009" "0.934" "1.047" "1.055" "123.3" "112.0" "132.8" "126.7" "123.7" "130.4" "124.4" "115.1" "129.0" "130.0" "" "" "" "" "" "" "" "" "" "" "123.3" "94.7" "84.0" "92.4" "101.4" "101.3" "95.9" "99.0" "100.7" "116.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426417921420304223" "False" "High" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRP4K PE=1 SV=3" "0.000" "False" "9.208" "3" "3" "3" "3" "1007" "116.9" "10.26" "5.56" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.112" "1.154" "1.084" "1.190" "1.323" "1.222" "1.186" "1.271" "1.150" "149.0" "165.7" "172.0" "161.5" "177.3" "197.2" "182.1" "176.8" "189.5" "171.4" "" "" "" "" "" "" "" "" "" "" "149.0" "140.1" "108.8" "117.8" "145.3" "153.1" "140.4" "152.0" "147.9" "154.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.000" "False" "9.194" "18" "3" "5" "3" "137" "15.7" "12.02" "15.50" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.019" "1.354" "1.085" "1.080" "1.362" "1.094" "1.208" "1.402" "1.113" "396.1" "403.5" "536.3" "429.8" "427.7" "539.5" "433.3" "478.5" "555.3" "440.6" "" "" "" "" "" "" "" "" "" "" "396.1" "341.4" "339.1" "313.4" "350.4" "419.0" "334.0" "411.4" "433.4" "396.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "9.191" "6" "3" "3" "1" "494" "56.6" "11.52" "8.54" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-909250529717419183" "False" "High" "IsMasterProtein" "P26447" "Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1" "0.000" "False" "9.187" "17" "2" "4" "2" "101" "11.7" "6.11" "9.69" "2" "signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01023" "6275" "ENSG00000196154" "S100A4" "A8K7R8; D3DV46; hsa:6275; P26447; Q6ICP8" "Vitamin D receptor pathway" "" "1" "0" "1.066" "1.011" "1.085" "1.071" "1.049" "1.254" "1.052" "1.091" "0.937" "277.9" "296.4" "281.1" "301.4" "297.5" "291.4" "348.6" "292.3" "303.3" "260.3" "" "" "" "" "" "" "" "" "" "" "277.9" "250.7" "177.7" "219.8" "243.8" "226.3" "268.7" "251.4" "236.8" "234.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7312432654099933298" "False" "High" "IsMasterProtein" "Q8WUF5" "RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4" "0.000" "False" "9.182" "4" "3" "3" "3" "828" "89.0" "6.81" "6.95" "3" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796, Pf14604" "10848" "ENSG00000104881" "PPP1R13L" "hsa:10848; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q8WUF5; Q9Y290" "IL-18 signaling pathway" "Regulation of TP53 Activity through Association with Co-factors" "2" "0" "0.878" "0.985" "0.961" "1.157" "0.995" "1.030" "1.357" "0.850" "0.882" "118.5" "104.0" "116.7" "113.9" "137.0" "117.9" "122.1" "160.8" "100.8" "104.5" "" "" "" "" "" "" "" "" "" "" "118.5" "88.0" "73.8" "83.1" "112.3" "91.6" "94.1" "138.3" "78.7" "94.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.000" "False" "9.165" "3" "2" "3" "2" "698" "77.6" "6.49" "9.79" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "10" "0" "1.026" "0.995" "1.026" "1.034" "1.023" "1.025" "1.109" "1.035" "1.161" "178.4" "182.9" "177.4" "183.1" "184.3" "182.4" "182.8" "197.9" "184.6" "207.1" "" "" "" "" "" "" "" "" "" "" "178.4" "154.8" "112.2" "133.5" "151.0" "141.6" "140.9" "170.1" "144.1" "186.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1385876623079047354" "False" "High" "IsMasterProtein" "Q9UFC0" "Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2" "0.000" "False" "9.156" "4" "2" "2" "2" "647" "70.8" "7.21" "7.86" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf00560" "222229" "ENSG00000161036" "LRWD1" "A8K4K2; B2R9G2; hsa:222229; Q8N0T9; Q8WV43; Q96GJ2; Q9UFC0" "Male infertility" "" "1" "0" "1.063" "0.788" "0.978" "1.019" "0.800" "0.852" "0.897" "0.762" "0.914" "90.4" "96.1" "71.2" "88.4" "92.2" "72.3" "77.0" "81.1" "68.9" "82.6" "" "" "" "" "" "" "" "" "" "" "90.4" "81.3" "45.0" "64.4" "75.5" "56.2" "59.4" "69.7" "53.8" "74.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "9.145" "3" "1" "2" "1" "439" "48.5" "7.03" "8.40" "1" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "Glutamate and glutamine metabolism" "4" "0" "1.013" "0.877" "1.034" "1.016" "0.962" "1.003" "0.953" "0.895" "1.045" "114.8" "116.3" "100.7" "118.7" "116.7" "110.5" "115.2" "109.5" "102.7" "120.0" "" "" "" "" "" "" "" "" "" "" "114.8" "98.4" "63.6" "86.5" "95.6" "85.8" "88.8" "94.1" "80.2" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "9.144" "5" "1" "1" "1" "454" "49.8" "5.10" "5.45" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "1.150" "0.952" "1.166" "1.210" "0.954" "1.241" "1.041" "1.024" "0.945" "23.4" "26.9" "22.2" "27.2" "28.3" "22.3" "29.0" "24.3" "23.9" "22.1" "" "" "" "" "" "" "" "" "" "" "23.4" "22.7" "14.1" "19.9" "23.2" "17.3" "22.3" "20.9" "18.7" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "9.141" "7" "3" "3" "3" "327" "36.7" "9.52" "10.66" "3" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "Rett syndrome" "HCMV Early Events; HDACs deacetylate histones; PPARA activates gene expression; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity" "7" "0" "0.984" "0.897" "0.981" "0.992" "0.948" "1.016" "0.919" "1.009" "0.976" "286.7" "281.9" "257.1" "281.3" "284.4" "271.9" "291.3" "263.4" "289.2" "279.8" "" "" "" "" "" "" "" "" "" "" "286.7" "238.5" "162.6" "205.1" "233.0" "211.1" "224.5" "226.5" "225.7" "251.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.000" "False" "9.140" "8" "4" "4" "4" "398" "45.3" "8.90" "10.40" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "17" "0" "1.128" "0.778" "1.069" "1.124" "0.954" "1.072" "1.091" "0.893" "1.075" "180.8" "204.0" "140.7" "193.2" "203.3" "172.4" "193.9" "197.3" "161.5" "194.3" "" "" "" "" "" "" "" "" "" "" "180.8" "172.6" "89.0" "140.9" "166.5" "133.9" "149.4" "169.6" "126.0" "174.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "9.127" "2" "3" "3" "3" "2266" "252.3" "6.60" "9.80" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Gastric cancer network 2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "9.127" "8" "3" "3" "3" "331" "37.6" "6.92" "9.24" "3" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "Regulation of TP53 Activity through Phosphorylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "24" "0" "1.147" "0.968" "1.236" "1.231" "1.209" "1.124" "1.115" "1.017" "1.120" "23.4" "26.9" "22.7" "29.0" "28.8" "28.3" "26.3" "26.1" "23.8" "26.2" "" "" "" "" "" "" "" "" "" "" "23.4" "22.7" "14.3" "21.1" "23.6" "22.0" "20.3" "22.5" "18.6" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "9.125" "3" "2" "2" "2" "820" "95.5" "9.55" "8.79" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.052" "1.176" "1.205" "1.273" "1.238" "1.124" "1.217" "1.298" "1.140" "97.6" "102.6" "114.7" "117.6" "124.2" "120.8" "109.6" "118.7" "126.7" "111.2" "" "" "" "" "" "" "" "" "" "" "97.6" "86.8" "72.5" "85.7" "101.7" "93.8" "84.5" "102.0" "98.9" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.000" "False" "9.120" "8" "2" "2" "2" "441" "49.3" "6.25" "2.13" "2" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "1.230" "1.243" "1.633" "0.973" "2.180" "1.131" "1.049" "1.850" "0.910" "38.8" "47.7" "48.2" "63.3" "37.7" "84.5" "43.8" "40.6" "71.7" "35.3" "" "" "" "" "" "" "" "" "" "" "38.8" "40.3" "30.5" "46.1" "30.9" "65.6" "33.8" "34.9" "56.0" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.000" "False" "9.110" "10" "2" "2" "2" "200" "22.5" "5.92" "7.13" "2" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "" "Neddylation" "1" "0" "0.950" "0.946" "0.972" "0.881" "0.908" "1.031" "0.915" "0.925" "0.947" "187.9" "178.4" "177.8" "182.7" "165.5" "170.7" "193.7" "171.8" "173.7" "177.9" "" "" "" "" "" "" "" "" "" "" "187.9" "151.0" "112.4" "133.2" "135.6" "132.5" "149.3" "147.8" "135.6" "159.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "9.106" "10" "3" "3" "3" "279" "31.7" "7.05" "9.06" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.094" "0.956" "0.965" "1.033" "0.891" "0.710" "0.873" "1.045" "0.928" "364.9" "399.1" "348.8" "352.2" "376.8" "325.2" "259.0" "318.4" "381.3" "338.7" "" "" "" "" "" "" "" "" "" "" "364.9" "337.6" "220.5" "256.8" "308.7" "252.6" "199.6" "273.8" "297.7" "304.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.000" "False" "9.078" "7" "2" "2" "2" "329" "36.1" "5.69" "7.85" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.989" "1.023" "1.112" "1.052" "0.948" "1.065" "1.113" "0.877" "1.100" "155.5" "153.8" "159.1" "172.9" "163.6" "147.4" "165.6" "173.1" "136.4" "171.0" "" "" "" "" "" "" "" "" "" "" "155.5" "130.1" "100.6" "126.1" "134.0" "114.5" "127.6" "148.8" "106.4" "153.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808857115210323645" "False" "High" "IsMasterProtein" "Q9UFF9" "CCR4-NOT transcription complex subunit 8 OS=Homo sapiens OX=9606 GN=CNOT8 PE=1 SV=1" "0.000" "False" "9.075" "13" "3" "3" "3" "292" "33.5" "4.81" "8.90" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "9337" "ENSG00000155508" "CNOT8" "B0AZS3; B2RAR8; B7Z8R1; D3DQI8; hsa:9337; O95709; Q7Z521; Q9H6Y1; Q9UFF9" "" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "3" "0" "0.896" "0.829" "0.988" "0.905" "1.013" "1.170" "1.134" "0.873" "1.156" "28.7" "25.7" "23.8" "28.4" "26.0" "29.1" "33.6" "32.6" "25.1" "33.2" "" "" "" "" "" "" "" "" "" "" "28.7" "21.8" "15.1" "20.7" "21.3" "22.6" "25.9" "28.0" "19.6" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "9.069" "6" "2" "2" "2" "471" "54.5" "5.00" "7.08" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "1.098" "0.830" "1.300" "1.439" "1.342" "1.307" "1.221" "0.996" "1.167" "29.7" "32.6" "24.6" "38.6" "42.7" "39.8" "38.8" "36.2" "29.6" "34.6" "" "" "" "" "" "" "" "" "" "" "29.7" "27.6" "15.6" "28.1" "35.0" "30.9" "29.9" "31.2" "23.1" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "High" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.000" "False" "9.065" "2" "2" "2" "1" "815" "92.1" "6.28" "7.23" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "9.043" "13" "3" "4" "3" "217" "24.8" "9.94" "11.36" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.997" "1.442" "1.113" "1.152" "1.587" "1.058" "1.419" "1.484" "1.185" "174.7" "174.1" "251.9" "194.5" "201.3" "277.2" "184.8" "247.9" "259.3" "207.0" "" "" "" "" "" "" "" "" "" "" "174.7" "147.3" "159.3" "141.8" "164.9" "215.3" "142.5" "213.2" "202.4" "186.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "9.037" "3" "3" "3" "3" "877" "96.7" "7.37" "9.52" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.346" "1.068" "1.157" "1.250" "1.298" "1.285" "1.362" "1.431" "1.034" "189.7" "255.2" "202.6" "219.4" "237.2" "246.3" "243.8" "258.4" "271.5" "196.1" "" "" "" "" "" "" "" "" "" "" "189.7" "215.9" "128.1" "160.0" "194.4" "191.3" "187.9" "222.1" "211.9" "176.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "9.033" "18" "4" "4" "4" "184" "21.4" "5.11" "11.24" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "4" "0" "1.065" "0.932" "1.103" "1.042" "0.844" "1.027" "1.036" "0.948" "0.982" "135.7" "144.5" "126.5" "149.6" "141.3" "114.5" "139.3" "140.5" "128.6" "133.3" "" "" "" "" "" "" "" "" "" "" "135.7" "122.2" "80.0" "109.1" "115.8" "88.9" "107.4" "120.8" "100.4" "119.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.000" "False" "9.022" "4" "1" "2" "1" "382" "40.4" "7.96" "5.69" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "0.983" "1.004" "1.199" "0.929" "0.926" "1.023" "1.006" "0.991" "0.966" "51.8" "50.9" "52.0" "62.1" "48.1" "47.9" "53.0" "52.1" "51.3" "50.0" "" "" "" "" "" "" "" "" "" "" "51.8" "43.0" "32.9" "45.3" "39.4" "37.2" "40.8" "44.8" "40.0" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5035986382802710418" "False" "High" "IsMasterProtein" "Q9NUB1" "Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2" "0.000" "False" "9.019" "4" "3" "3" "3" "689" "74.8" "7.11" "10.61" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193, Pf16177" "84532" "ENSG00000154930" "ACSS1" "B3KXL2; B4DJZ3; D3DW48; F5H6F4; F8W7Y1; hsa:84532; Q5TF42; Q8IV99; Q8N234; Q96JI1; Q96JX6; Q9NU28; Q9NUB1" "Sterol regulatory element-binding proteins (SREBP) signaling; Amino acid metabolism; Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "Ethanol oxidation" "5" "0" "1.040" "1.068" "0.927" "1.032" "1.018" "1.002" "1.072" "1.007" "0.999" "203.8" "211.9" "217.7" "189.0" "210.3" "207.5" "204.2" "218.5" "205.3" "203.6" "" "" "" "" "" "" "" "" "" "" "203.8" "179.3" "137.6" "137.8" "172.3" "161.1" "157.4" "187.9" "160.2" "183.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "9.018" "8" "3" "3" "3" "400" "46.5" "5.24" "8.58" "3" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-958825745261361591" "False" "High" "IsMasterProtein" "Q7Z3J2" "VPS35 endosomal protein-sorting factor-like OS=Homo sapiens OX=9606 GN=VPS35L PE=1 SV=2" "0.000" "False" "9.012" "3" "3" "3" "3" "963" "109.5" "7.21" "8.99" "3" "transport" "plasma membrane;other membranes;other cytoplasmic organelle" "" "" "57020" "ENSG00000103544" "VPS35L" "A8K2M1; hsa:57020; O43329; Q69YI1; Q6PDA0; Q7L371; Q7Z3J2; Q86W66; Q8WXA5; Q9H0L7; Q9H7C8" "" "Neutrophil degranulation" "1" "0" "0.907" "1.024" "1.056" "1.051" "0.977" "1.076" "0.978" "0.928" "1.038" "127.8" "115.9" "130.8" "135.0" "134.3" "124.8" "137.5" "125.0" "118.6" "132.7" "" "" "" "" "" "" "" "" "" "" "127.8" "98.1" "82.7" "98.4" "110.1" "96.9" "106.0" "107.4" "92.6" "119.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "9.006" "20" "3" "3" "3" "147" "16.8" "5.35" "8.76" "3" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.000" "1.111" "1.034" "1.191" "1.017" "1.104" "1.092" "1.030" "1.197" "63.9" "63.8" "70.9" "66.0" "76.0" "64.9" "70.5" "69.7" "65.8" "76.5" "" "" "" "" "" "" "" "" "" "" "63.9" "54.0" "44.9" "48.2" "62.3" "50.4" "54.3" "59.9" "51.3" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.000" "False" "8.993" "11" "1" "2" "1" "171" "18.6" "4.58" "6.58" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "" "tRNA processing in the nucleus" "1" "0" "0.926" "0.848" "0.939" "0.949" "0.853" "0.808" "1.169" "0.945" "0.931" "36.5" "33.8" "31.0" "34.3" "34.7" "31.2" "29.5" "42.7" "34.5" "34.0" "" "" "" "" "" "" "" "" "" "" "36.5" "28.6" "19.6" "25.0" "28.4" "24.2" "22.7" "36.7" "26.9" "30.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "8.982" "9" "3" "4" "3" "246" "28.0" "8.44" "12.12" "3" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "5" "0" "0.925" "3.427" "1.123" "0.962" "3.313" "0.986" "0.917" "3.542" "1.669" "254.3" "235.3" "871.7" "285.5" "244.6" "842.7" "250.8" "233.3" "900.9" "424.4" "" "" "" "" "" "" "" "" "" "" "254.3" "199.1" "551.2" "208.2" "200.4" "654.4" "193.3" "200.6" "703.2" "381.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778501702482241288" "False" "High" "IsMasterProtein" "P41182" "B-cell lymphoma 6 protein OS=Homo sapiens OX=9606 GN=BCL6 PE=1 SV=1" "0.000" "False" "8.973" "3" "2" "3" "2" "706" "78.8" "7.94" "10.11" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "604" "ENSG00000113916" "BCL6" "A7E241; B8PSA7; D3DNV5; hsa:604; P41182" "B cell receptor signaling pathway; Vitamin D receptor pathway; MECP2 and associated Rett syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Extrafollicular and follicular B cell activation by SARS-CoV-2; DNA damage response (only ATM dependent)" "Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; FOXO-mediated transcription of cell death genes" "9" "0" "0.914" "1.427" "1.520" "1.459" "1.421" "1.273" "1.278" "1.039" "0.872" "14.9" "13.6" "21.3" "22.7" "21.8" "21.2" "19.0" "19.1" "15.5" "13.0" "" "" "" "" "" "" "" "" "" "" "14.9" "11.5" "13.5" "16.6" "17.9" "16.5" "14.7" "16.4" "12.1" "11.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1591325911363533533" "False" "High" "IsMasterProtein" "Q8NFV4" "sn-1-specific diacylglycerol lipase ABHD11 OS=Homo sapiens OX=9606 GN=ABHD11 PE=1 SV=2" "0.000" "False" "8.970" "7" "2" "2" "2" "306" "33.7" "9.19" "6.08" "2" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00561" "83451" "ENSG00000106077" "ABHD11" "H7BYM8; hsa:83451; Q6PJU0; Q8N722; Q8N723; Q8NFV2; Q8NFV3; Q8NFV4; Q9HBS8" "7q11.23 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "8.964" "14" "3" "3" "3" "188" "20.8" "9.66" "8.63" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.970" "0.771" "0.830" "0.988" "0.972" "0.952" "0.837" "0.815" "0.885" "52.9" "51.3" "40.8" "43.9" "52.2" "51.4" "50.3" "44.3" "43.1" "46.8" "" "" "" "" "" "" "" "" "" "" "52.9" "43.4" "25.8" "32.0" "42.8" "39.9" "38.8" "38.1" "33.6" "42.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "8.959" "3" "2" "2" "2" "725" "83.6" "7.05" "6.75" "2" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.237" "1.136" "1.008" "1.204" "0.946" "1.034" "1.216" "0.863" "0.926" "77.5" "95.9" "88.1" "78.1" "93.3" "73.3" "80.1" "94.2" "66.9" "71.8" "" "" "" "" "" "" "" "" "" "" "77.5" "81.1" "55.7" "56.9" "76.4" "56.9" "61.8" "81.0" "52.2" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "8.956" "32" "2" "5" "2" "87" "10.0" "6.57" "15.61" "2" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "Mitochondrial Fatty Acid Beta-Oxidation" "6" "0" "0.890" "1.038" "0.944" "0.973" "1.057" "1.145" "0.934" "0.966" "0.928" "642.0" "571.5" "666.6" "606.2" "625.0" "678.6" "735.1" "599.8" "620.2" "595.5" "" "" "" "" "" "" "" "" "" "" "642.0" "483.5" "421.5" "442.0" "512.1" "527.0" "566.7" "515.7" "484.1" "535.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972887412222597887" "False" "High" "IsMasterProtein" "Q9UIS9" "Methyl-CpG-binding domain protein 1 OS=Homo sapiens OX=9606 GN=MBD1 PE=1 SV=2" "0.000" "False" "8.949" "5" "3" "3" "3" "605" "66.6" "9.04" "9.29" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf02008" "4152" "ENSG00000141644" "MBD1" "A4UTZ0; B4DXJ5; E9PEC5; hsa:4152; K7ELI2; K7EQZ4; K7ESN0; O15248; O95241; Q7Z7B5; Q8N4W4; Q9UIS9; Q9UNZ6; Q9UNZ7; Q9UNZ8; Q9UNZ9" "Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription cofactors" "2" "0" "1.001" "0.732" "1.138" "1.131" "0.868" "1.110" "1.246" "0.824" "0.994" "111.5" "111.7" "81.7" "126.9" "126.1" "96.8" "123.8" "138.9" "91.8" "110.9" "" "" "" "" "" "" "" "" "" "" "111.5" "94.5" "51.6" "92.5" "103.3" "75.1" "95.4" "119.4" "71.7" "99.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "8.935" "5" "2" "2" "2" "458" "48.8" "10.07" "6.87" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "Mitochondrial protein degradation" "6" "0" "1.068" "0.939" "1.133" "1.134" "0.904" "1.091" "1.126" "0.942" "1.014" "128.1" "136.8" "120.3" "145.1" "145.2" "115.8" "139.8" "144.2" "120.7" "129.9" "" "" "" "" "" "" "" "" "" "" "128.1" "115.8" "76.0" "105.8" "119.0" "90.0" "107.8" "124.0" "94.2" "116.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "8.930" "5" "4" "4" "2" "766" "84.4" "7.53" "8.80" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "56" "1" "1.033" "1.128" "1.075" "0.836" "1.105" "1.000" "1.061" "1.112" "1.002" "75.4" "77.9" "85.0" "81.0" "63.1" "83.3" "75.4" "80.0" "83.8" "75.5" "" "" "" "" "" "" "" "" "" "" "75.4" "65.9" "53.8" "59.1" "51.7" "64.7" "58.1" "68.7" "65.4" "67.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "8.928" "33" "3" "6" "2" "79" "9.7" "8.94" "17.72" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "Small cell lung cancer" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "3" "0" "1.075" "1.013" "0.981" "1.059" "0.878" "1.093" "1.012" "0.869" "1.044" "240.5" "258.6" "243.6" "235.9" "254.6" "211.2" "262.8" "243.4" "209.0" "251.0" "" "" "" "" "" "" "" "" "" "" "240.5" "218.7" "154.0" "172.0" "208.6" "164.0" "202.6" "209.3" "163.2" "225.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "8.926" "5" "3" "3" "3" "559" "64.0" "8.12" "9.26" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "36" "0" "1.091" "0.954" "1.131" "1.084" "0.858" "1.068" "1.082" "0.995" "0.917" "180.0" "196.4" "171.8" "203.6" "195.2" "154.4" "192.2" "194.9" "179.2" "165.0" "" "" "" "" "" "" "" "" "" "" "180.0" "166.2" "108.6" "148.5" "159.9" "119.9" "148.2" "167.5" "139.8" "148.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3116404034014267296" "False" "High" "IsMasterProtein" "Q5U5Q3" "RNA-binding E3 ubiquitin-protein ligase MEX3C OS=Homo sapiens OX=9606 GN=MEX3C PE=1 SV=3" "0.000" "False" "8.919" "5" "3" "3" "3" "659" "69.3" "5.00" "5.79" "3" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "51320" "ENSG00000176624" "MEX3C" "A1L022; Q5U5Q3; Q9NZE3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "8.914" "28" "3" "4" "3" "99" "11.3" "9.31" "12.29" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "1.010" "1.080" "1.180" "1.111" "1.035" "1.135" "0.985" "0.912" "1.279" "37.4" "37.8" "40.4" "44.2" "41.6" "38.8" "42.5" "36.9" "34.2" "47.9" "" "" "" "" "" "" "" "" "" "" "37.4" "32.0" "25.6" "32.2" "34.1" "30.1" "32.8" "31.7" "26.7" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "High" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.000" "False" "8.900" "8" "5" "5" "5" "576" "64.1" "8.37" "13.39" "5" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "" "Synthesis of very long-chain fatty acyl-CoAs" "1" "0" "1.094" "0.950" "0.970" "1.110" "0.908" "1.091" "1.040" "0.989" "1.053" "333.3" "364.5" "316.7" "323.2" "369.9" "302.7" "363.6" "346.6" "329.8" "350.8" "" "" "" "" "" "" "" "" "" "" "333.3" "308.4" "200.2" "235.7" "303.1" "235.1" "280.3" "298.0" "257.4" "315.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747450166338589829" "False" "High" "IsMasterProtein" "Q8IUE6" "Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3" "0.000" "False" "8.897" "18" "3" "6" "1" "130" "14.0" "10.89" "16.43" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "317772" "ENSG00000184270" "H2AC21" "hsa:317772; Q8IUE6" "" "HCMV Early Events; UCH proteinases; Ub-specific processing proteases; HCMV Late Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines; HATs acetylate histones" "8" "0" "1.329" "1.158" "1.421" "1.393" "1.208" "1.336" "1.164" "1.278" "1.432" "41.2" "54.7" "47.7" "58.5" "57.3" "49.7" "55.0" "47.9" "52.6" "58.9" "" "" "" "" "" "" "" "" "" "" "41.2" "46.3" "30.1" "42.6" "47.0" "38.6" "42.4" "41.2" "41.1" "53.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "8.894" "13" "2" "4" "2" "176" "20.1" "6.39" "11.95" "2" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "0.811" "0.992" "1.122" "1.119" "0.973" "0.958" "0.703" "1.199" "1.324" "27.5" "22.3" "27.3" "30.9" "30.8" "26.8" "26.4" "19.4" "33.0" "36.5" "" "" "" "" "" "" "" "" "" "" "27.5" "18.9" "17.3" "22.5" "25.2" "20.8" "20.3" "16.6" "25.8" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "8.894" "19" "3" "3" "3" "144" "17.0" "8.82" "9.69" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.962" "1.044" "0.893" "0.793" "0.967" "0.806" "0.786" "0.893" "0.937" "285.6" "274.8" "298.2" "255.0" "226.4" "276.2" "230.3" "224.5" "255.0" "267.6" "" "" "" "" "" "" "" "" "" "" "285.6" "232.5" "188.5" "185.9" "185.5" "214.5" "177.5" "193.0" "199.0" "240.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "8.893" "19" "3" "3" "3" "153" "17.9" "5.06" "9.47" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.000" "False" "8.889" "22" "2" "2" "2" "160" "17.8" "9.41" "7.47" "2" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "1.207" "1.090" "1.128" "1.291" "1.011" "1.322" "1.275" "1.173" "1.196" "53.0" "64.0" "57.7" "59.7" "68.4" "53.6" "70.0" "67.5" "62.1" "63.4" "" "" "" "" "" "" "" "" "" "" "53.0" "54.1" "36.5" "43.6" "56.0" "41.6" "54.0" "58.1" "48.5" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "8.878" "3" "2" "2" "2" "808" "92.1" "5.53" "7.00" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Cell cycle" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.116" "1.001" "1.173" "0.967" "1.001" "0.943" "0.968" "0.975" "1.005" "46.1" "51.4" "46.1" "54.1" "44.6" "46.1" "43.5" "44.6" "45.0" "46.3" "" "" "" "" "" "" "" "" "" "" "46.1" "43.5" "29.2" "39.4" "36.5" "35.8" "33.5" "38.4" "35.1" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "8.874" "3" "2" "2" "2" "683" "78.5" "6.87" "6.45" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "4" "0" "1.009" "1.196" "1.100" "1.018" "0.968" "1.060" "0.991" "1.064" "1.149" "94.5" "95.3" "113.1" "104.0" "96.2" "91.5" "100.2" "93.7" "100.5" "108.6" "" "" "" "" "" "" "" "" "" "" "94.5" "80.7" "71.5" "75.8" "78.8" "71.1" "77.2" "80.6" "78.5" "97.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "8.870" "4" "3" "3" "3" "822" "93.8" "5.22" "10.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.080" "0.910" "1.001" "1.061" "0.973" "1.169" "1.023" "0.915" "1.024" "86.7" "93.6" "78.9" "86.8" "92.0" "84.3" "101.3" "88.7" "79.3" "88.8" "" "" "" "" "" "" "" "" "" "" "86.7" "79.2" "49.9" "63.3" "75.4" "65.5" "78.1" "76.2" "61.9" "79.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2027123753413932420" "False" "High" "IsMasterProtein" "Q8NBN7" "Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2" "0.000" "False" "8.865" "7" "2" "2" "2" "331" "35.9" "8.10" "7.49" "2" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00106" "112724" "ENSG00000160439; ENSG00000273944; ENSG00000274418; ENSG00000274504; ENSG00000275474; ENSG00000276341; ENSG00000276684; ENSG00000276826; ENSG00000278149; ENSG00000278284" "RDH13" "Q6UX79; Q8NBN7; Q96G88" "" "RA biosynthesis pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7912852613905627854" "False" "High" "IsMasterProtein" "Q01196" "Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3" "0.000" "False" "8.859" "10" "4" "4" "4" "453" "48.7" "9.35" "10.75" "4" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "861" "ENSG00000159216" "RUNX1" "A8MV94; B2RMS4; D3DSG1; hsa:861; O60472; O60473; O76047; O76089; Q01196; Q13081; Q13755; Q13756; Q13757; Q13758; Q13759; Q15341; Q15343; Q16122; Q16284; Q16285; Q16286; Q16346; Q16347; Q92479" "Hematopoietic stem cell differentiation; Dual hijack model of Vif in HIV infection; Orexin receptor pathway; Th17 cell differentiation pathway; Acute myeloid leukemia" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Estrogen-dependent gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; Pre-NOTCH Transcription and Translation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Organic cation transport; SARS-CoV-1 activates/modulates innate immune responses; Transcriptional regulation of granulopoiesis; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling" "24" "0" "1.110" "0.986" "1.152" "1.038" "1.093" "1.218" "1.083" "0.995" "0.969" "98.8" "109.7" "97.5" "113.8" "102.6" "108.1" "120.4" "107.0" "98.3" "95.7" "" "" "" "" "" "" "" "" "" "" "98.8" "92.8" "61.6" "83.0" "84.0" "83.9" "92.8" "92.0" "76.7" "86.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.000" "False" "8.854" "4" "2" "2" "2" "619" "70.1" "8.51" "7.49" "2" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "mRNA processing" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1713406968265840354" "False" "High" "IsMasterProtein" "O60825" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2" "0.000" "False" "8.852" "7" "4" "4" "4" "505" "58.4" "8.38" "11.35" "4" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5208" "ENSG00000123836" "PFKFB2" "hsa:5208; O60824; O60825; Q5VVQ3; Q5VVQ4; Q9H3P1" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "1.290" "0.972" "1.017" "1.205" "0.926" "1.051" "1.262" "1.011" "1.191" "48.0" "61.9" "46.7" "48.8" "57.9" "44.4" "50.5" "60.6" "48.6" "57.2" "" "" "" "" "" "" "" "" "" "" "48.0" "52.4" "29.5" "35.6" "47.4" "34.5" "38.9" "52.1" "37.9" "51.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "High" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.000" "False" "8.843" "5" "2" "2" "2" "368" "42.1" "6.21" "7.28" "2" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "1.056" "1.209" "1.112" "1.253" "1.263" "1.232" "1.285" "1.194" "1.104" "130.3" "137.6" "157.6" "145.0" "163.3" "164.6" "160.6" "167.5" "155.6" "143.9" "" "" "" "" "" "" "" "" "" "" "130.3" "116.4" "99.6" "105.7" "133.8" "127.8" "123.8" "144.0" "121.5" "129.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "8.837" "16" "3" "3" "3" "151" "16.6" "7.65" "9.81" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Neutrophil degranulation; LDL clearance" "7" "0" "0.916" "1.134" "0.959" "0.962" "1.095" "1.000" "0.912" "1.040" "0.989" "211.2" "193.4" "239.3" "202.6" "203.1" "231.3" "211.1" "192.5" "219.7" "208.7" "" "" "" "" "" "" "" "" "" "" "211.2" "163.7" "151.3" "147.7" "166.4" "179.6" "162.8" "165.5" "171.5" "187.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "High" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.000" "False" "8.831" "3" "2" "2" "2" "680" "74.5" "5.11" "7.08" "2" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "1.241" "0.989" "1.254" "1.577" "1.249" "1.291" "1.490" "1.016" "1.404" "45.2" "56.1" "44.7" "56.7" "71.3" "56.4" "58.4" "67.3" "45.9" "63.5" "" "" "" "" "" "" "" "" "" "" "45.2" "47.5" "28.3" "41.3" "58.4" "43.8" "45.0" "57.9" "35.8" "57.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.000" "False" "8.829" "6" "4" "4" "4" "655" "76.0" "5.88" "5.85" "4" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle" "6" "0" "0.946" "0.808" "0.956" "0.987" "1.140" "0.931" "1.095" "0.888" "1.069" "56.2" "53.2" "45.4" "53.7" "55.5" "64.1" "52.3" "61.6" "49.9" "60.0" "" "" "" "" "" "" "" "" "" "" "56.2" "45.0" "28.7" "39.2" "45.4" "49.8" "40.3" "52.9" "38.9" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "8.816" "3" "4" "4" "2" "1088" "118.1" "6.28" "10.81" "4" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "1.071" "1.129" "1.125" "1.108" "1.024" "1.064" "1.181" "1.230" "0.979" "60.2" "64.5" "68.0" "67.7" "66.7" "61.6" "64.0" "71.1" "74.0" "58.9" "" "" "" "" "" "" "" "" "" "" "60.2" "54.5" "43.0" "49.4" "54.6" "47.9" "49.4" "61.1" "57.8" "53.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.000" "False" "8.814" "6" "3" "4" "3" "417" "46.5" "5.60" "10.44" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.347" "0.972" "1.176" "1.173" "1.211" "1.098" "1.232" "1.342" "1.338" "93.9" "126.5" "91.3" "110.5" "110.2" "113.7" "103.1" "115.7" "126.0" "125.7" "" "" "" "" "" "" "" "" "" "" "93.9" "107.0" "57.7" "80.6" "90.3" "88.3" "79.5" "99.5" "98.4" "113.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "8.805" "3" "2" "4" "2" "537" "60.6" "4.84" "9.85" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Nucleotide-binding oligomerization domain (NOD) pathway" "Regulation of the apoptosome activity" "3" "0" "1.034" "0.876" "1.185" "1.026" "0.963" "1.119" "1.011" "0.918" "0.994" "94.6" "97.9" "82.9" "112.2" "97.1" "91.1" "105.9" "95.7" "86.9" "94.1" "" "" "" "" "" "" "" "" "" "" "94.6" "82.8" "52.4" "81.8" "79.5" "70.8" "81.6" "82.3" "67.8" "84.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3022549876159517749" "False" "High" "IsMasterProtein" "Q9H8W4" "Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1" "0.000" "False" "8.803" "8" "2" "2" "2" "249" "27.8" "8.21" "6.95" "2" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169, Pf01363" "79666" "ENSG00000175895" "PLEKHF2" "hsa:79666; Q9H8W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.000" "False" "8.799" "10" "5" "5" "5" "519" "59.5" "6.90" "8.12" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3330412660782960382" "False" "High" "IsMasterProtein" "Q16594" "Transcription initiation factor TFIID subunit 9 OS=Homo sapiens OX=9606 GN=TAF9 PE=1 SV=1" "0.000" "False" "8.790" "10" "3" "5" "3" "264" "29.0" "8.66" "13.14" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02291" "6880" "ENSG00000273841; ENSG00000276463" "TAF9" "D3DWA3; hsa:6880; Q16594; Q5U0D1; Q9BTS1" "Eukaryotic transcription initiation" "HATs acetylate histones; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "12" "0" "0.949" "1.001" "0.962" "1.053" "0.952" "1.133" "1.013" "0.951" "1.146" "76.1" "72.2" "76.1" "73.1" "80.1" "72.4" "86.2" "77.1" "72.3" "87.2" "" "" "" "" "" "" "" "" "" "" "76.1" "61.1" "48.1" "53.3" "65.6" "56.2" "66.4" "66.3" "56.4" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7763347901800507563" "False" "High" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=3" "0.000" "False" "8.781" "5" "2" "2" "2" "425" "47.2" "8.66" "7.18" "2" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "ENSG00000169499" "PLEKHA2" "A8K727; hsa:59339; Q9HB19" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "1.104" "0.839" "1.204" "0.911" "0.929" "1.263" "1.106" "0.934" "1.013" "72.1" "79.6" "60.5" "86.8" "65.7" "67.0" "91.1" "79.8" "67.3" "73.1" "" "" "" "" "" "" "" "" "" "" "72.1" "67.4" "38.3" "63.3" "53.8" "52.1" "70.2" "68.6" "52.6" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8289862670679680301" "False" "High" "IsMasterProtein" "Q96EK7" "Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1" "0.000" "False" "8.755" "5" "4" "4" "4" "910" "103.7" "5.69" "9.63" "4" "signal transduction;other biological processes" "nucleus" "" "" "84498" "ENSG00000112584; ENSG00000275333" "FAM120B" "B4DL34; hsa:84498; Q86V68; Q96EK7; Q96JI9" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "2" "0" "1.094" "1.089" "1.072" "1.142" "1.006" "0.993" "1.115" "1.039" "1.083" "278.7" "304.8" "303.4" "298.8" "318.3" "280.3" "276.7" "310.6" "289.5" "301.8" "" "" "" "" "" "" "" "" "" "" "278.7" "257.8" "191.8" "217.9" "260.8" "217.6" "213.3" "267.1" "226.0" "271.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-401785042072942350" "False" "High" "IsMasterProtein" "O94808" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Homo sapiens OX=9606 GN=GFPT2 PE=1 SV=3" "0.000" "False" "8.754" "4" "3" "4" "1" "682" "76.9" "7.37" "10.78" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "9945" "ENSG00000131459" "GFPT2" "hsa:9945; O94808; Q53XM2; Q9BWS4" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.092" "0.893" "0.914" "1.311" "1.237" "1.202" "1.119" "0.911" "1.121" "88.9" "97.1" "79.3" "81.2" "116.6" "109.9" "106.8" "99.4" "81.0" "99.6" "" "" "" "" "" "" "" "" "" "" "88.9" "82.1" "50.2" "59.2" "95.5" "85.4" "82.3" "85.5" "63.2" "89.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "High" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.000" "False" "8.745" "6" "2" "2" "2" "360" "40.2" "4.82" "6.90" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "1.052" "0.772" "1.176" "1.091" "0.811" "1.072" "0.850" "0.766" "0.954" "86.2" "90.7" "66.6" "101.4" "94.1" "69.9" "92.4" "73.3" "66.1" "82.3" "" "" "" "" "" "" "" "" "" "" "86.2" "76.7" "42.1" "73.9" "77.1" "54.3" "71.2" "63.0" "51.6" "74.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "High" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.000" "False" "8.743" "3" "3" "3" "3" "917" "99.0" "9.07" "8.09" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "0.973" "0.701" "1.096" "1.042" "0.935" "1.125" "1.071" "0.741" "0.998" "86.3" "84.0" "60.5" "94.6" "89.9" "80.7" "97.1" "92.4" "64.0" "86.2" "" "" "" "" "" "" "" "" "" "" "86.3" "71.1" "38.2" "68.9" "73.7" "62.6" "74.8" "79.5" "49.9" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "8.734" "5" "3" "4" "3" "655" "70.3" "8.75" "9.71" "3" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "4" "0" "1.134" "1.427" "1.456" "1.280" "1.181" "1.202" "0.973" "1.582" "1.295" "19.5" "22.1" "27.8" "28.4" "24.9" "23.0" "23.4" "19.0" "30.8" "25.2" "" "" "" "" "" "" "" "" "" "" "19.5" "18.7" "17.6" "20.7" "20.4" "17.9" "18.0" "16.3" "24.1" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-161088924712109766" "False" "High" "IsMasterProtein" "Q96RU2" "Ubiquitin carboxyl-terminal hydrolase 28 OS=Homo sapiens OX=9606 GN=USP28 PE=1 SV=1" "0.000" "False" "8.720" "5" "4" "4" "4" "1077" "122.4" "5.20" "7.79" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57646" "ENSG00000048028" "USP28" "B0YJC0; B0YJC1; hsa:57646; Q6NZX9; Q96RU2; Q9P213" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "0.997" "0.710" "1.031" "1.196" "1.023" "1.021" "1.255" "0.689" "0.884" "12.6" "12.6" "8.9" "13.0" "15.1" "12.9" "12.9" "15.8" "8.7" "11.1" "" "" "" "" "" "" "" "" "" "" "12.6" "10.6" "5.7" "9.5" "12.3" "10.0" "9.9" "13.6" "6.8" "10.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624689202228352756" "False" "High" "IsMasterProtein" "Q8IWJ2" "GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4" "0.000" "False" "8.705" "2" "4" "4" "4" "1684" "195.8" "5.14" "10.61" "4" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01465, Pf16704" "9648" "ENSG00000135968" "GCC2" "A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8" "Deregulation of Rab and Rab effector genes in bladder cancer" "Retrograde transport at the Trans-Golgi-Network; Signaling by ALK fusions and activated point mutants" "3" "0" "1.047" "1.048" "1.061" "1.029" "1.016" "1.016" "1.044" "1.152" "1.231" "166.0" "173.8" "174.1" "176.1" "170.9" "168.7" "168.8" "173.3" "191.3" "204.5" "" "" "" "" "" "" "" "" "" "" "166.0" "147.0" "110.1" "128.4" "140.0" "131.0" "130.1" "149.0" "149.4" "183.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.000" "False" "8.695" "9" "3" "3" "3" "312" "34.7" "5.41" "9.54" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "" "COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017591020137158396" "False" "High" "IsMasterProtein" "O14966" "Ras-related protein Rab-7L1 OS=Homo sapiens OX=9606 GN=RAB29 PE=1 SV=1" "0.000" "False" "8.693" "9" "2" "3" "2" "203" "23.1" "7.18" "8.38" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "8934" "ENSG00000117280" "RAB29" "B4E1K3; C9JE77; hsa:8934; O14966" "" "RAB geranylgeranylation" "1" "0" "0.919" "1.065" "0.936" "0.798" "0.978" "0.870" "1.002" "0.939" "0.938" "228.0" "209.5" "242.7" "213.4" "182.0" "223.0" "198.2" "228.5" "214.1" "213.7" "" "" "" "" "" "" "" "" "" "" "228.0" "177.3" "153.5" "155.6" "149.1" "173.2" "152.8" "196.4" "167.1" "192.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "8.691" "6" "2" "2" "2" "547" "59.2" "6.29" "7.73" "2" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.102" "1.130" "0.872" "1.172" "1.189" "1.187" "0.989" "0.839" "0.826" "13.0" "14.3" "14.7" "11.3" "15.2" "15.5" "15.4" "12.9" "10.9" "10.7" "" "" "" "" "" "" "" "" "" "" "13.0" "12.1" "9.3" "8.3" "12.5" "12.0" "11.9" "11.1" "8.5" "9.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2269954353219987429" "False" "High" "IsMasterProtein" "O43927" "C-X-C motif chemokine 13 OS=Homo sapiens OX=9606 GN=CXCL13 PE=1 SV=1" "0.000" "False" "8.679" "13" "1" "2" "1" "109" "12.7" "10.33" "8.40" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00048" "10563" "ENSG00000156234" "CXCL13" "hsa:10563; O43927" "Allograft rejection; Chemokine signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Overview of proinflammatory and profibrotic mediators; 2q13 copy number variation syndrome" "G alpha (i) signalling events; Chemokine receptors bind chemokines" "7" "0" "1.079" "0.839" "1.022" "1.127" "1.365" "1.423" "1.318" "0.878" "1.260" "23.7" "25.6" "19.9" "24.2" "26.7" "32.3" "33.7" "31.2" "20.8" "29.8" "" "" "" "" "" "" "" "" "" "" "23.7" "21.6" "12.6" "17.7" "21.9" "25.1" "26.0" "26.8" "16.2" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "8.670" "9" "3" "3" "3" "307" "33.7" "8.21" "9.27" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "Fatty acid biosynthesis" "" "1" "0" "1.049" "1.096" "1.053" "1.085" "0.987" "1.066" "0.952" "1.053" "1.089" "149.9" "157.2" "164.3" "157.9" "162.6" "147.9" "159.9" "142.7" "157.9" "163.2" "" "" "" "" "" "" "" "" "" "" "149.9" "133.0" "103.9" "115.1" "133.2" "114.8" "123.2" "122.7" "123.2" "146.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4643888973216991338" "False" "High" "IsMasterProtein" "Q9Y4F3" "Meiosis regulator and mRNA stability factor 1 OS=Homo sapiens OX=9606 GN=MARF1 PE=1 SV=6" "0.000" "False" "8.659" "1" "3" "4" "3" "1742" "192.7" "7.87" "9.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf01936, Pf11608, Pf12872, Pf19687" "9665" "ENSG00000166783; ENSG00000277140" "MARF1" "A8MSK2; B2RNX2; B4DYY9; B7ZMG1; B7ZMG2; F8VV09; hsa:9665; Q6P1R6; Q8WYR2; Q9Y4F3; Q9Y4J9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3080210265663367666" "False" "High" "IsMasterProtein" "Q8IY37" "Probable ATP-dependent RNA helicase DHX37 OS=Homo sapiens OX=9606 GN=DHX37 PE=1 SV=1" "0.000" "False" "8.657" "2" "1" "1" "1" "1157" "129.5" "8.10" "4.28" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "57647" "ENSG00000150990" "DHX37" "hsa:57647; Q8IY37; Q9BUI7; Q9P211" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2141575905927618539" "False" "High" "IsMasterProtein" "P79483" "HLA class II histocompatibility antigen, DR beta 3 chain OS=Homo sapiens OX=9606 GN=HLA-DRB3 PE=1 SV=1" "0.000" "False" "8.656" "10" "3" "3" "2" "266" "29.9" "8.56" "9.82" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3125" "ENSG00000196101; ENSG00000231679" "HLA-DRB3" "A0ZXY9; A7MA46; B5AU12; B5AU13; B5AU14; B8YAC6; C6H115; C6H116; O02875; O19590; O46701; O46794; O78049; O78162; P01913; P79483; P79663; Q29721; Q29809; Q2PPD0; Q30144; Q507L8; Q5SP44; Q5STE0; Q6YJU6; Q70M87; Q7YQ62; Q860I9; Q8SP69; Q8WLT7; Q8WLT8; Q95359; Q95HM8; Q95IE5; Q96H16; Q9BCP3; Q9BD18; Q9MYA4; Q9MYH3; Q9MYH4; Q9TP01; Q9TP02; Q9TPB5; Q9TQ21; Q9UIN3; Q9UIN5" "Allograft rejection; Ebola virus infection in host" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "8.655" "6" "3" "3" "3" "458" "50.3" "6.61" "8.95" "3" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7020233943661812607" "False" "High" "IsMasterProtein" "Q9NUJ3" "T-complex protein 11-like protein 1 OS=Homo sapiens OX=9606 GN=TCP11L1 PE=1 SV=1" "0.000" "False" "8.646" "6" "3" "3" "3" "509" "57.0" "5.59" "9.30" "3" "signal transduction" "cytoskeleton" "" "Pf05794" "55346" "ENSG00000176148" "TCP11L1" "D3DR01; hsa:55346; Q8IVX4; Q9NUJ3" "" "" "0" "0" "0.969" "0.851" "1.095" "1.143" "0.931" "1.071" "0.930" "0.981" "1.041" "148.2" "143.6" "126.1" "162.2" "169.3" "138.0" "158.7" "137.8" "145.3" "154.2" "" "" "" "" "" "" "" "" "" "" "148.2" "121.5" "79.7" "118.3" "138.7" "107.2" "122.3" "118.5" "113.4" "138.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855314221236891810" "False" "High" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "0.000" "False" "8.640" "2" "2" "2" "2" "858" "94.2" "5.26" "7.00" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "8.637" "10" "2" "4" "2" "186" "21.4" "7.77" "12.78" "2" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "" "Neutrophil degranulation" "1" "0" "1.031" "1.066" "1.086" "1.015" "1.096" "1.145" "1.056" "1.058" "1.027" "379.7" "391.5" "404.8" "412.2" "385.3" "416.2" "434.9" "400.8" "401.5" "390.1" "" "" "" "" "" "" "" "" "" "" "379.7" "331.2" "256.0" "300.5" "315.7" "323.2" "335.2" "344.6" "313.4" "350.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.000" "False" "8.637" "24" "3" "4" "2" "104" "12.0" "6.80" "9.99" "3" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "" "Phenylalanine metabolism" "1" "0" "1.039" "1.121" "1.099" "1.089" "1.165" "1.059" "1.030" "1.142" "1.154" "136.0" "141.3" "152.5" "149.5" "148.1" "158.4" "144.0" "140.1" "155.2" "156.9" "" "" "" "" "" "" "" "" "" "" "136.0" "119.5" "96.4" "109.0" "121.3" "123.0" "111.0" "120.5" "121.2" "141.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8083299006508235950" "False" "High" "IsMasterProtein" "O94761" "ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2" "0.000" "False" "8.633" "2" "2" "2" "2" "1208" "133.0" "8.09" "8.71" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11719" "9401" "ENSG00000160957" "RECQL4" "A0A087WZ30; hsa:9401; O94761; Q3Y424; Q96DW2; Q96F55" "Primary ovarian insufficiency" "" "1" "0" "1.148" "0.791" "1.134" "1.228" "0.841" "1.325" "1.181" "0.858" "0.914" "68.3" "78.4" "54.0" "77.4" "83.9" "57.4" "90.5" "80.6" "58.6" "62.4" "" "" "" "" "" "" "" "" "" "" "68.3" "66.3" "34.2" "56.4" "68.7" "44.6" "69.7" "69.3" "45.7" "56.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "8.625" "17" "4" "5" "4" "184" "20.5" "5.92" "16.36" "4" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "mTORC1-mediated signalling; Macroautophagy; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "26" "0" "1.027" "1.003" "1.011" "0.940" "1.100" "1.023" "1.003" "1.081" "1.060" "491.9" "505.1" "493.4" "497.5" "462.2" "541.2" "503.1" "493.2" "531.9" "521.4" "" "" "" "" "" "" "" "" "" "" "491.9" "427.3" "312.0" "362.8" "378.7" "420.3" "387.8" "424.1" "415.2" "468.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4300221756741418571" "False" "High" "IsMasterProtein" "P59768" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 OS=Homo sapiens OX=9606 GN=GNG2 PE=1 SV=2" "0.000" "False" "8.605" "23" "1" "2" "1" "71" "7.8" "7.99" "7.69" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "54331" "ENSG00000186469" "GNG2" "hsa:54331; P59768; Q5JPE2; Q6P9A9" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "0.687" "1.228" "1.201" "1.065" "0.987" "1.065" "1.088" "0.889" "1.025" "26.1" "17.9" "32.0" "31.3" "27.7" "25.7" "27.7" "28.4" "23.2" "26.7" "" "" "" "" "" "" "" "" "" "" "26.1" "15.1" "20.2" "22.8" "22.7" "20.0" "21.4" "24.4" "18.1" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "8.598" "6" "3" "4" "3" "433" "48.3" "7.47" "12.32" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "33" "0" "1.024" "0.820" "1.061" "0.877" "0.943" "1.058" "1.031" "0.961" "0.775" "66.3" "67.9" "54.4" "70.4" "58.1" "62.5" "70.1" "68.3" "63.7" "51.4" "" "" "" "" "" "" "" "" "" "" "66.3" "57.4" "34.4" "51.3" "47.6" "48.5" "54.1" "58.7" "49.7" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "8.596" "4" "2" "2" "2" "465" "52.5" "7.39" "6.12" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "0.992" "0.852" "1.218" "1.056" "0.940" "1.021" "1.056" "0.834" "1.037" "77.7" "77.1" "66.2" "94.7" "82.1" "73.1" "79.4" "82.1" "64.8" "80.6" "" "" "" "" "" "" "" "" "" "" "77.7" "65.2" "41.9" "69.0" "67.3" "56.8" "61.2" "70.6" "50.6" "72.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "8.592" "5" "4" "6" "3" "747" "85.1" "7.69" "12.17" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "5" "0" "1.079" "0.980" "0.991" "1.174" "1.120" "1.041" "1.082" "1.047" "1.047" "196.0" "211.6" "192.2" "194.2" "230.1" "219.5" "204.0" "212.0" "205.3" "205.3" "" "" "" "" "" "" "" "" "" "" "196.0" "179.0" "121.5" "141.6" "188.5" "170.4" "157.2" "182.3" "160.3" "184.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "8.589" "3" "4" "5" "4" "1368" "156.4" "7.40" "13.78" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "" "PPARA activates gene expression; RSV-host interactions; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway" "4" "0" "1.089" "1.011" "0.993" "1.168" "1.026" "1.089" "1.117" "1.074" "1.003" "360.6" "392.8" "364.6" "358.0" "421.2" "370.1" "392.5" "402.9" "387.4" "361.7" "" "" "" "" "" "" "" "" "" "" "360.6" "332.4" "230.6" "261.0" "345.1" "287.4" "302.6" "346.4" "302.4" "325.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068779671623766038" "False" "High" "IsMasterProtein" "A6NJ78" "12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1" "0.000" "False" "8.587" "5" "2" "2" "2" "407" "46.1" "8.62" "7.33" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf01795" "196074" "ENSG00000169519" "METTL15" "A6NJ78; A8MRS5; B7WNU2; hsa:196074; Q3MHD3; Q8N601; Q8NBA7" "" "" "0" "0" "0.917" "0.809" "1.150" "1.112" "0.821" "0.969" "0.920" "0.911" "0.957" "124.3" "114.0" "100.5" "143.0" "138.2" "102.1" "120.4" "114.4" "113.3" "119.0" "" "" "" "" "" "" "" "" "" "" "124.3" "96.4" "63.6" "104.3" "113.2" "79.3" "92.8" "98.4" "88.4" "107.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.000" "False" "8.583" "2" "2" "3" "2" "1068" "118.4" "5.41" "9.16" "2" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.034" "0.813" "0.814" "1.034" "0.725" "1.001" "0.927" "0.730" "0.714" "40.9" "42.2" "33.2" "33.3" "42.2" "29.6" "40.9" "37.9" "29.8" "29.2" "" "" "" "" "" "" "" "" "" "" "40.9" "35.7" "21.0" "24.2" "34.6" "23.0" "31.5" "32.6" "23.3" "26.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8687914292583263366" "False" "High" "IsMasterProtein" "O60307" "Microtubule-associated serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=MAST3 PE=1 SV=2" "0.000" "False" "8.575" "2" "3" "3" "2" "1309" "143.0" "8.06" "8.53" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "23031" "ENSG00000099308" "MAST3" "hsa:23031; O60307; Q7LDZ8; Q9UPI0" "" "" "0" "0" "1.071" "0.956" "1.161" "1.008" "0.745" "1.230" "0.998" "0.781" "1.006" "45.1" "48.4" "43.1" "52.4" "45.5" "33.6" "55.5" "45.1" "35.2" "45.4" "" "" "" "" "" "" "" "" "" "" "45.1" "40.9" "27.3" "38.2" "37.3" "26.1" "42.8" "38.7" "27.5" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "8.566" "7" "3" "3" "3" "362" "40.5" "6.70" "9.14" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Methionine metabolism leading to sulfur amino acids and related disorders" "Ribavirin ADME; Purine salvage" "3" "0" "1.067" "0.885" "0.937" "0.978" "1.132" "1.155" "0.989" "1.125" "1.009" "67.0" "71.5" "59.3" "62.8" "65.6" "75.9" "77.4" "66.3" "75.4" "67.6" "" "" "" "" "" "" "" "" "" "" "67.0" "60.5" "37.5" "45.8" "53.7" "58.9" "59.7" "57.0" "58.8" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.000" "False" "8.560" "3" "4" "4" "4" "1250" "140.4" "5.25" "7.71" "4" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "0.950" "0.988" "0.999" "1.011" "0.943" "0.976" "1.019" "0.904" "0.954" "263.0" "249.8" "259.9" "262.8" "265.9" "248.1" "256.7" "268.0" "237.8" "250.9" "" "" "" "" "" "" "" "" "" "" "263.0" "211.3" "164.3" "191.6" "217.8" "192.7" "197.9" "230.5" "185.6" "225.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3950704505580312253" "False" "High" "IsMasterProtein" "Q9BVI4" "Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1" "0.000" "False" "8.555" "6" "3" "3" "3" "516" "58.4" "7.49" "7.86" "3" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "" "Pf03914" "79050" "ENSG00000184967; ENSG00000288146" "NOC4L" "hsa:79050; Q8N2S5; Q96I14; Q9BVI4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.045" "0.745" "0.880" "1.069" "0.796" "1.192" "1.083" "0.663" "0.884" "146.0" "152.6" "108.8" "128.5" "156.1" "116.2" "174.1" "158.2" "96.8" "129.1" "" "" "" "" "" "" "" "" "" "" "146.0" "129.1" "68.8" "93.7" "127.9" "90.2" "134.2" "136.0" "75.5" "116.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "8.554" "2" "3" "6" "1" "1512" "164.8" "9.69" "17.04" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2285465926165935505" "False" "High" "IsMasterProtein" "Q8WVN8" "Ubiquitin-conjugating enzyme E2 Q2 OS=Homo sapiens OX=9606 GN=UBE2Q2 PE=1 SV=1" "0.000" "False" "8.552" "9" "4" "4" "1" "375" "42.8" "4.96" "10.75" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179, Pf05773" "92912" "ENSG00000140367" "UBE2Q2" "B7Z3Q2; H3BRG2; hsa:92912; Q8N4G6; Q8WVN8; Q96J08" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "8.544" "8" "2" "3" "2" "399" "44.2" "5.10" "7.09" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Amino acids regulate mTORC1; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK" "10" "0" "0.930" "1.170" "1.409" "1.202" "1.144" "1.257" "0.954" "1.044" "1.218" "17.7" "16.5" "20.7" "25.0" "21.3" "20.3" "22.3" "16.9" "18.5" "21.6" "" "" "" "" "" "" "" "" "" "" "17.7" "13.9" "13.1" "18.2" "17.5" "15.7" "17.2" "14.5" "14.4" "19.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2488299377452803712" "False" "High" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "0.000" "False" "8.543" "4" "2" "2" "2" "703" "82.5" "5.14" "6.88" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "1.300" "2.367" "1.013" "1.091" "2.677" "1.273" "1.344" "2.551" "1.490" "49.4" "64.2" "117.0" "50.0" "53.9" "132.3" "62.9" "66.4" "126.0" "73.6" "" "" "" "" "" "" "" "" "" "" "49.4" "54.3" "74.0" "36.5" "44.2" "102.7" "48.5" "57.1" "98.4" "66.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "8.533" "9" "3" "3" "3" "340" "38.1" "5.41" "9.31" "3" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7161908197236874210" "False" "High" "IsMasterProtein" "Q9BTV5" "Fibronectin type III and SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FSD1 PE=1 SV=1" "0.000" "False" "8.517" "7" "3" "3" "3" "496" "55.8" "6.99" "10.59" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00041, Pf00622" "79187" "ENSG00000105255" "FSD1" "B2RDT0; hsa:79187; Q9BTV5; Q9BXN0; Q9HAG4" "" "" "0" "0" "0.965" "0.727" "0.820" "1.254" "1.105" "1.058" "1.040" "1.338" "1.065" "27.5" "26.6" "20.0" "22.6" "34.5" "30.4" "29.1" "28.6" "36.8" "29.3" "" "" "" "" "" "" "" "" "" "" "27.5" "22.5" "12.7" "16.5" "28.3" "23.6" "22.5" "24.6" "28.8" "26.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "8.501" "33" "3" "3" "3" "80" "9.1" "9.58" "8.92" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "0.901" "1.000" "0.918" "0.993" "1.090" "0.994" "0.928" "1.118" "1.107" "298.6" "269.0" "298.5" "274.2" "296.5" "325.4" "296.8" "277.0" "333.8" "330.6" "" "" "" "" "" "" "" "" "" "" "298.6" "227.5" "188.7" "199.9" "242.9" "252.7" "228.8" "238.1" "260.6" "297.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "8.494" "7" "3" "3" "3" "424" "48.0" "6.29" "9.60" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "EGF/EGFR signaling pathway" "Metalloprotease DUBs" "2" "0" "0.990" "0.843" "0.966" "1.083" "0.772" "1.022" "0.961" "0.882" "1.009" "96.5" "95.6" "81.4" "93.2" "104.5" "74.5" "98.6" "92.7" "85.1" "97.4" "" "" "" "" "" "" "" "" "" "" "96.5" "80.8" "51.5" "68.0" "85.7" "57.8" "76.0" "79.7" "66.4" "87.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "8.481" "3" "4" "4" "4" "1148" "128.2" "9.36" "9.10" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "22" "0" "1.003" "1.138" "1.125" "1.131" "1.047" "1.081" "0.966" "1.082" "1.032" "180.6" "181.1" "205.5" "203.1" "204.2" "189.0" "195.3" "174.4" "195.4" "186.4" "" "" "" "" "" "" "" "" "" "" "180.6" "153.2" "129.9" "148.1" "167.3" "146.8" "150.5" "149.9" "152.5" "167.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "8.462" "10" "2" "2" "1" "211" "23.3" "8.91" "6.36" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "8.448" "12" "2" "3" "2" "193" "22.8" "9.76" "10.31" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "1.155" "1.215" "1.259" "1.141" "1.385" "1.085" "1.167" "1.334" "1.178" "164.3" "189.8" "199.6" "206.9" "187.5" "227.5" "178.3" "191.7" "219.1" "193.6" "" "" "" "" "" "" "" "" "" "" "164.3" "160.5" "126.2" "150.8" "153.6" "176.7" "137.5" "164.8" "171.1" "174.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172314789071643693" "False" "High" "IsMasterProtein" "Q8IWV7" "E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1" "0.000" "False" "8.444" "2" "3" "3" "3" "1749" "200.1" "6.01" "6.95" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "197131" "ENSG00000159459" "UBR1" "O60708; O75492; Q14D45; Q68DN9; Q8IWV7; Q8IWY6; Q96JY4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.939" "0.940" "1.078" "0.986" "1.004" "1.048" "1.131" "0.861" "0.984" "38.3" "36.0" "36.0" "41.3" "37.8" "38.5" "40.2" "43.4" "33.0" "37.7" "" "" "" "" "" "" "" "" "" "" "38.3" "30.5" "22.8" "30.1" "31.0" "29.9" "31.0" "37.3" "25.7" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "High" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.000" "False" "8.429" "4" "4" "5" "4" "1003" "113.6" "8.82" "13.54" "4" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "VEGFA-VEGFR2 signaling" "MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "19" "0" "1.980" "1.317" "0.997" "1.495" "0.977" "1.088" "0.889" "0.971" "1.007" "109.6" "217.1" "144.4" "109.3" "163.9" "107.2" "119.2" "97.4" "106.5" "110.4" "" "" "" "" "" "" "" "" "" "" "109.6" "183.7" "91.3" "79.7" "134.3" "83.2" "91.9" "83.8" "83.1" "99.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "8.422" "24" "5" "7" "5" "186" "21.1" "5.47" "15.74" "5" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "11" "0" "0.944" "0.917" "0.979" "1.002" "0.955" "0.993" "0.994" "0.981" "0.987" "215.3" "203.2" "197.5" "210.7" "215.6" "205.6" "213.9" "214.0" "211.1" "212.5" "" "" "" "" "" "" "" "" "" "" "215.3" "171.9" "124.9" "153.6" "176.7" "159.7" "164.9" "184.0" "164.8" "191.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3539568279205584801" "False" "High" "IsMasterProtein" "P57764" "Gasdermin-D OS=Homo sapiens OX=9606 GN=GSDMD PE=1 SV=1" "0.000" "False" "8.412" "6" "2" "2" "2" "484" "52.8" "5.08" "7.31" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "79792" "ENSG00000104518; ENSG00000278718" "GSDMD" "A8K702; D3DWJ9; hsa:79792; P57764; Q96Q98" "STING pathway in Kawasaki-like disease and COVID-19" "Neutrophil degranulation; Regulation of TLR by endogenous ligand; Purinergic signaling in leishmaniasis infection; Release of apoptotic factors from the mitochondria; Pyroptosis; Interleukin-1 processing" "7" "0" "1.308" "0.719" "1.193" "1.074" "1.273" "1.231" "1.218" "1.072" "1.330" "24.9" "32.5" "17.9" "29.7" "26.7" "31.7" "30.6" "30.3" "26.6" "33.1" "" "" "" "" "" "" "" "" "" "" "24.9" "27.5" "11.3" "21.6" "21.9" "24.6" "23.6" "26.0" "20.8" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "8.411" "16" "4" "5" "4" "212" "24.7" "8.19" "14.75" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "0.943" "1.030" "1.006" "0.991" "0.913" "0.965" "0.963" "1.006" "1.046" "393.0" "370.4" "404.7" "395.3" "389.3" "358.9" "379.4" "378.4" "395.4" "411.1" "" "" "" "" "" "" "" "" "" "" "393.0" "313.4" "255.9" "288.2" "318.9" "278.7" "292.4" "325.3" "308.7" "369.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912099457443708123" "False" "High" "IsMasterProtein" "O43913" "Origin recognition complex subunit 5 OS=Homo sapiens OX=9606 GN=ORC5 PE=1 SV=1" "0.000" "False" "8.407" "6" "3" "3" "3" "435" "50.3" "7.74" "9.26" "3" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14630, Pf21639" "5001" "ENSG00000164815" "ORC5" "A4D0P8; hsa:5001; O43913; O60590; O95268" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "0.936" "0.663" "0.923" "0.970" "0.773" "1.046" "1.061" "0.730" "0.849" "71.6" "67.1" "47.5" "66.1" "69.5" "55.3" "74.9" "76.0" "52.3" "60.8" "" "" "" "" "" "" "" "" "" "" "71.6" "56.7" "30.0" "48.2" "56.9" "43.0" "57.8" "65.3" "40.8" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "8.405" "15" "3" "4" "3" "228" "24.9" "5.58" "14.01" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway" "3" "0" "0.964" "1.069" "1.006" "1.008" "1.027" "0.970" "1.086" "1.160" "0.966" "467.1" "450.3" "499.1" "470.1" "471.0" "479.9" "453.0" "507.1" "541.8" "451.2" "" "" "" "" "" "" "" "" "" "" "467.1" "381.0" "315.6" "342.8" "385.9" "372.7" "349.2" "436.0" "422.9" "405.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5956791852298741945" "False" "High" "IsMasterProtein" "Q9UPY8" "Microtubule-associated protein RP/EB family member 3 OS=Homo sapiens OX=9606 GN=MAPRE3 PE=1 SV=1" "0.000" "False" "8.399" "6" "2" "6" "1" "281" "32.0" "5.54" "13.12" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22924" "ENSG00000084764" "MAPRE3" "B7WPK5; hsa:22924; O00265; Q6FHB0; Q6FI15; Q9BZP7; Q9BZP8; Q9UPY8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "8.394" "18" "3" "3" "3" "147" "15.9" "8.21" "10.39" "3" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.959" "0.992" "0.921" "1.020" "0.964" "1.071" "1.041" "1.016" "1.057" "353.8" "339.5" "351.0" "325.7" "361.1" "340.9" "378.8" "368.2" "359.5" "373.9" "" "" "" "" "" "" "" "" "" "" "353.8" "287.2" "221.9" "237.5" "295.8" "264.8" "292.0" "316.6" "280.6" "336.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990882527068196170" "False" "High" "IsMasterProtein" "Cont_P56652" "Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus OX=9913 GN=ITIH3 PE=1 SV=2" "0.000" "True" "8.368" "3" "3" "3" "3" "891" "99.5" "5.90" "9.23" "3" "other metabolic processes" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "508355" "ENSBIXG00000030288; ENSBTAG00000007846" "ITIH3" "A0A4W2BJV2; A7MB92; bta:508355; P56652; Q0V8M9" "" "Platelet degranulation" "1" "0" "0.883" "0.942" "0.897" "0.809" "0.961" "1.050" "1.084" "1.027" "0.890" "98.4" "86.9" "92.7" "88.3" "79.5" "94.5" "103.3" "106.6" "101.0" "87.5" "" "" "" "" "" "" "" "" "" "" "98.4" "73.5" "58.6" "64.4" "65.2" "73.4" "79.6" "91.7" "78.9" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "8.365" "6" "2" "2" "2" "463" "52.5" "7.55" "7.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.026" "0.899" "1.265" "0.930" "0.797" "1.378" "0.735" "0.843" "0.938" "18.5" "19.0" "16.6" "23.4" "17.2" "14.7" "25.5" "13.6" "15.6" "17.3" "" "" "" "" "" "" "" "" "" "" "18.5" "16.1" "10.5" "17.1" "14.1" "11.4" "19.6" "11.7" "12.2" "15.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "8.349" "8" "3" "3" "2" "293" "33.3" "6.93" "9.45" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "10" "0" "0.921" "0.892" "1.058" "0.981" "0.798" "1.015" "1.044" "0.866" "1.019" "153.0" "140.9" "136.4" "161.8" "150.0" "122.1" "155.2" "159.7" "132.5" "155.9" "" "" "" "" "" "" "" "" "" "" "153.0" "119.2" "86.3" "118.0" "122.9" "94.8" "119.6" "137.3" "103.4" "140.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "8.348" "5" "3" "3" "3" "591" "66.5" "6.93" "10.06" "3" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Regulation of actin cytoskeleton" "Generation of second messenger molecules; Signaling by ROBO receptors" "3" "0" "1.245" "1.269" "1.245" "1.194" "1.287" "1.241" "1.266" "1.202" "1.133" "70.4" "87.6" "89.3" "87.6" "84.0" "90.6" "87.4" "89.1" "84.6" "79.8" "" "" "" "" "" "" "" "" "" "" "70.4" "74.1" "56.5" "63.9" "68.8" "70.4" "67.4" "76.6" "66.1" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017174203569406372" "False" "High" "IsMasterProtein" "Q86UW6" "NEDD4-binding protein 2 OS=Homo sapiens OX=9606 GN=N4BP2 PE=1 SV=2" "0.000" "False" "8.333" "2" "3" "3" "3" "1770" "198.7" "5.21" "5.95" "3" "DNA metabolism" "cytosol" "kinase activity;other molecular function" "Pf01713, Pf08590, Pf13671" "55728" "ENSG00000078177" "N4BP2" "A0AVR3; hsa:55728; Q86UW6; Q9NVK2; Q9P2D4" "" "" "0" "0" "1.066" "0.930" "1.093" "1.083" "1.027" "1.166" "1.075" "1.008" "1.038" "86.8" "92.5" "80.7" "94.8" "93.9" "89.1" "101.2" "93.2" "87.5" "90.1" "" "" "" "" "" "" "" "" "" "" "86.8" "78.2" "51.0" "69.1" "77.0" "69.2" "78.0" "80.2" "68.3" "81.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7529838149184307642" "False" "High" "IsMasterProtein" "P04066" "Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4" "0.000" "False" "8.325" "6" "3" "3" "3" "466" "53.7" "6.84" "8.69" "3" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01120, Pf16757" "2517" "ENSG00000179163" "FUCA1" "B2RBG3; hsa:2517; P04066; Q14334; Q14335; Q3LID0; Q8NAC2" "p53 transcriptional gene network" "Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway" "3" "0" "0.837" "0.951" "0.956" "1.020" "1.037" "1.015" "0.989" "1.023" "1.071" "176.2" "147.5" "167.5" "168.4" "179.7" "182.8" "178.8" "174.2" "180.2" "188.7" "" "" "" "" "" "" "" "" "" "" "176.2" "124.8" "105.9" "122.8" "147.2" "141.9" "137.9" "149.8" "140.6" "169.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "8.315" "20" "1" "1" "1" "123" "13.8" "6.52" "6.46" "1" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "1.482" "1.283" "1.658" "1.315" "0.939" "1.569" "0.996" "1.132" "1.169" "12.7" "18.8" "16.3" "21.1" "16.7" "11.9" "19.9" "12.7" "14.4" "14.9" "" "" "" "" "" "" "" "" "" "" "12.7" "15.9" "10.3" "15.4" "13.7" "9.3" "15.4" "10.9" "11.2" "13.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "8.303" "6" "3" "3" "3" "481" "55.6" "7.49" "7.82" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.210" "1.095" "1.127" "1.135" "1.178" "1.100" "1.197" "1.174" "1.059" "141.6" "171.4" "155.1" "159.6" "160.8" "166.8" "155.8" "169.5" "166.3" "150.0" "" "" "" "" "" "" "" "" "" "" "141.6" "145.0" "98.1" "116.4" "131.7" "129.6" "120.1" "145.8" "129.8" "134.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.000" "False" "8.301" "9" "2" "5" "2" "312" "33.6" "6.87" "6.15" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.189" "0.716" "0.836" "1.352" "1.038" "1.137" "1.094" "1.151" "1.259" "35.6" "42.3" "25.5" "29.8" "48.1" "36.9" "40.5" "38.9" "41.0" "44.8" "" "" "" "" "" "" "" "" "" "" "35.6" "35.8" "16.1" "21.7" "39.4" "28.7" "31.2" "33.5" "32.0" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7401329575601911727" "False" "High" "IsMasterProtein" "P13674" "Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2" "0.000" "False" "8.299" "5" "2" "2" "2" "534" "61.0" "6.01" "8.12" "2" "cell organization and biogenesis" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf08336, Pf13640" "5033" "ENSG00000122884" "P4HA1" "C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "8.295" "2" "2" "3" "2" "763" "85.5" "8.75" "9.50" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "G0 and Early G1" "3" "0" "1.313" "0.952" "1.232" "1.009" "1.045" "1.103" "1.019" "0.901" "0.903" "62.3" "81.8" "59.3" "76.8" "62.8" "65.1" "68.7" "63.5" "56.1" "56.3" "" "" "" "" "" "" "" "" "" "" "62.3" "69.2" "37.5" "56.0" "51.5" "50.6" "53.0" "54.6" "43.8" "50.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3879752315455634749" "False" "High" "IsMasterProtein" "O43822" "Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1" "0.000" "False" "8.294" "9" "2" "2" "2" "256" "28.3" "7.34" "7.26" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "755" "ENSG00000160226" "CFAP410" "A8MPS9; O14993; O43822; Q8N5X6; Q99837; Q99838" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "1.429" "0.735" "1.497" "1.501" "1.105" "1.347" "0.850" "1.241" "1.102" "16.6" "23.7" "12.2" "24.8" "24.9" "18.3" "22.3" "14.1" "20.6" "18.3" "" "" "" "" "" "" "" "" "" "" "16.6" "20.0" "7.7" "18.1" "20.4" "14.2" "17.2" "12.1" "16.1" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8340372604993352457" "False" "High" "IsMasterProtein" "Q9H4G0" "Band 4.1-like protein 1 OS=Homo sapiens OX=9606 GN=EPB41L1 PE=1 SV=2" "0.000" "False" "8.293" "3" "2" "4" "1" "881" "98.4" "5.62" "9.44" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2036" "ENSG00000088367" "EPB41L1" "hsa:2036; O15046; Q4VXM6; Q4VXM7; Q4VXM8; Q4VXN4; Q6ZT61; Q8IUU7; Q96CV5; Q96L65; Q9H4G0" "Splicing factor NOVA regulated synaptic proteins" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins; Trafficking of AMPA receptors" "5" "0" "1.076" "0.879" "1.040" "1.254" "0.754" "1.209" "1.097" "0.977" "1.407" "15.0" "16.1" "13.2" "15.6" "18.8" "11.3" "18.1" "16.4" "14.6" "21.1" "" "" "" "" "" "" "" "" "" "" "15.0" "13.6" "8.3" "11.4" "15.4" "8.8" "14.0" "14.1" "11.4" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8480986397388579687" "False" "High" "IsMasterProtein" "Q9UBB9" "Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1" "0.000" "False" "8.290" "3" "3" "3" "3" "837" "96.8" "5.67" "8.51" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "extracellular matrix;nucleus;other cell component" "nucleic acid binding activity" "Pf01585, Pf07842, Pf12457" "24144" "ENSG00000100109" "TFIP11" "hsa:24144; O95908; Q20WL0; Q5H8V8; Q9UBB9; Q9UGV7; Q9Y2Q8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.070" "0.955" "1.100" "1.233" "1.071" "1.044" "1.111" "1.119" "1.054" "144.2" "154.2" "137.7" "158.6" "177.7" "154.3" "150.5" "160.2" "161.3" "152.0" "" "" "" "" "" "" "" "" "" "" "144.2" "130.5" "87.1" "115.6" "145.6" "119.9" "116.0" "137.7" "125.9" "136.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5640697701811177027" "False" "High" "IsMasterProtein" "Q8TAG9" "Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3" "0.000" "False" "8.271" "3" "2" "2" "2" "804" "93.7" "6.20" "8.05" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf04091, Pf20651" "54536" "ENSG00000138190" "EXOC6" "E9PHI3; hsa:54536; Q5VXH8; Q8TAG9; Q9NZ24" "Interactions between LOXL4 and oxidative stress pathway; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "8.270" "6" "2" "2" "2" "312" "35.1" "9.13" "7.20" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "0.931" "1.035" "0.908" "0.925" "0.933" "0.864" "0.945" "0.755" "0.931" "186.1" "173.3" "192.7" "169.1" "172.1" "173.8" "160.9" "175.9" "140.5" "173.3" "" "" "" "" "" "" "" "" "" "" "186.1" "146.6" "121.8" "123.3" "141.0" "134.9" "124.0" "151.2" "109.7" "155.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "8.267" "9" "2" "2" "2" "276" "31.5" "7.64" "5.62" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.450" "1.222" "1.609" "1.168" "1.650" "0.846" "1.008" "1.279" "1.500" "20.7" "30.0" "25.3" "33.3" "24.2" "34.2" "17.5" "20.9" "26.5" "31.1" "" "" "" "" "" "" "" "" "" "" "20.7" "25.4" "16.0" "24.3" "19.8" "26.5" "13.5" "18.0" "20.7" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714438533049162384" "False" "High" "IsMasterProtein" "O94953" "Lysine-specific demethylase 4B OS=Homo sapiens OX=9606 GN=KDM4B PE=1 SV=4" "0.000" "False" "8.262" "2" "2" "2" "2" "1096" "121.8" "7.09" "5.19" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23030" "ENSG00000127663" "KDM4B" "B9EGN8; D6W631; hsa:23030; O75274; O94953; Q6P3R5; Q9P1V1; Q9UF40" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "8.257" "15" "3" "3" "3" "206" "23.6" "10.07" "9.97" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.999" "1.064" "0.963" "0.994" "0.952" "0.892" "0.928" "1.003" "1.063" "303.1" "302.7" "322.6" "291.8" "301.1" "288.7" "270.4" "281.2" "304.0" "322.3" "" "" "" "" "" "" "" "" "" "" "303.1" "256.1" "204.0" "212.8" "246.7" "224.2" "208.5" "241.8" "237.3" "289.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3849274809303235677" "False" "High" "IsMasterProtein" "Q6PHR2" "Serine/threonine-protein kinase ULK3 OS=Homo sapiens OX=9606 GN=ULK3 PE=1 SV=2" "0.000" "False" "8.255" "6" "3" "4" "3" "472" "53.4" "7.36" "9.58" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04212" "25989" "ENSG00000140474" "ULK3" "B2RXK3; B4DFT0; B4DRQ7; D3DW68; hsa:25989; Q6PHR2; Q9NPN5; Q9UFS4" "Target of rapamycin signaling" "Hedgehog 'on' state" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "8.253" "9" "3" "6" "3" "365" "41.3" "8.68" "13.81" "3" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "8.251" "18" "3" "5" "3" "169" "19.6" "9.51" "9.71" "3" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "1.112" "1.147" "0.954" "1.056" "1.446" "1.006" "1.078" "1.107" "1.012" "75.1" "83.5" "86.1" "71.7" "79.3" "108.6" "75.5" "81.0" "83.2" "76.0" "" "" "" "" "" "" "" "" "" "" "75.1" "70.6" "54.5" "52.3" "65.0" "84.3" "58.2" "69.6" "64.9" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643865994575879356" "False" "High" "IsMasterProtein" "Q7Z6M4" "Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3" "0.000" "False" "8.248" "6" "2" "3" "2" "381" "43.9" "4.82" "10.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf02536" "130916" "ENSG00000122085" "MTERF4" "A8K6K0; hsa:130916; Q7Z6M4; Q9P0E0" "CCL18 signaling pathway; 2q37 copy number variation syndrome" "rRNA modification in the mitochondrion" "3" "0" "1.137" "1.132" "1.031" "1.041" "1.074" "1.073" "1.125" "1.128" "1.082" "271.0" "308.1" "306.9" "279.5" "282.1" "291.2" "290.7" "304.8" "305.7" "293.1" "" "" "" "" "" "" "" "" "" "" "271.0" "260.7" "194.0" "203.8" "231.1" "226.1" "224.1" "262.1" "238.6" "263.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "8.241" "4" "2" "2" "2" "597" "68.8" "7.02" "6.73" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Cell cycle" "Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.000" "False" "8.238" "3" "3" "3" "3" "1118" "127.4" "8.51" "8.40" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "EGF/EGFR signaling pathway; Male infertility" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "6" "0" "1.026" "0.884" "0.991" "0.908" "0.826" "0.715" "0.814" "1.059" "1.004" "93.6" "96.1" "82.7" "92.8" "85.1" "77.4" "66.9" "76.2" "99.2" "94.0" "" "" "" "" "" "" "" "" "" "" "93.6" "81.3" "52.3" "67.7" "69.7" "60.1" "51.6" "65.5" "77.4" "84.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "8.235" "9" "3" "4" "3" "409" "47.2" "6.32" "5.04" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "" "Histidine catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "8.231" "6" "2" "2" "2" "321" "33.8" "10.18" "7.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Rubinstein-Taybi syndrome 1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.019" "1.008" "1.005" "1.054" "1.161" "1.139" "1.146" "1.072" "1.133" "267.2" "272.4" "269.4" "268.6" "281.6" "310.2" "304.5" "306.2" "286.5" "302.9" "" "" "" "" "" "" "" "" "" "" "267.2" "230.5" "170.3" "195.8" "230.7" "240.9" "234.7" "263.3" "223.6" "272.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457401366019025404" "False" "High" "IsMasterProtein" "Q7KZI7" "Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2" "0.000" "False" "8.224" "2" "2" "2" "2" "788" "87.9" "9.72" "6.75" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "2011" "ENSG00000072518" "MARK2" "hsa:2011; Q15449; Q15524; Q5XGA3; Q68A18; Q7KZI7; Q96HB3; Q96RG0" "Microtubule cytoskeleton regulation; Complement system in neuronal development and plasticity; Neurogenesis regulation in the olfactory epithelium" "" "3" "0" "1.068" "0.903" "1.091" "1.112" "1.059" "1.215" "1.111" "0.966" "1.000" "82.5" "88.1" "74.5" "90.0" "91.7" "87.4" "100.2" "91.6" "79.7" "82.5" "" "" "" "" "" "" "" "" "" "" "82.5" "74.5" "47.1" "65.6" "75.1" "67.9" "77.2" "78.8" "62.2" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.000" "False" "8.220" "4" "2" "2" "2" "434" "50.5" "11.33" "7.17" "2" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "1.107" "0.997" "1.087" "1.086" "1.173" "1.115" "1.001" "0.960" "1.051" "153.6" "170.0" "153.1" "167.0" "166.8" "180.1" "171.3" "153.8" "147.4" "161.3" "" "" "" "" "" "" "" "" "" "" "153.6" "143.8" "96.8" "121.7" "136.6" "139.9" "132.0" "132.2" "115.0" "145.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "8.219" "5" "2" "2" "2" "464" "49.9" "8.29" "7.74" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "0.956" "0.987" "1.146" "1.154" "1.212" "1.031" "1.121" "1.078" "1.187" "153.2" "146.4" "151.2" "175.6" "176.8" "185.7" "158.0" "171.7" "165.2" "181.9" "" "" "" "" "" "" "" "" "" "" "153.2" "123.9" "95.6" "128.0" "144.8" "144.2" "121.8" "147.6" "129.0" "163.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "8.216" "2" "2" "2" "2" "837" "92.3" "6.86" "7.20" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "1.064" "1.014" "1.105" "1.159" "1.031" "1.259" "1.192" "1.168" "1.147" "61.2" "65.1" "62.1" "67.7" "71.0" "63.1" "77.1" "73.0" "71.5" "70.2" "" "" "" "" "" "" "" "" "" "" "61.2" "55.1" "39.3" "49.3" "58.1" "49.0" "59.4" "62.7" "55.8" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3286506536231380161" "False" "High" "IsMasterProtein" "Q9NZI7" "Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1" "0.000" "False" "8.214" "6" "2" "2" "1" "540" "60.5" "6.35" "7.31" "2" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7342" "ENSG00000153560" "UBP1" "hsa:7342; Q68CT0; Q86Y57; Q9H8V0; Q9NZI7; Q9UD76; Q9UD78" "" "" "0" "0" "0.740" "0.620" "0.765" "0.760" "0.790" "0.929" "0.767" "0.694" "0.855" "60.0" "44.4" "37.2" "45.9" "45.6" "47.4" "55.8" "46.0" "41.6" "51.4" "" "" "" "" "" "" "" "" "" "" "60.0" "37.6" "23.5" "33.5" "37.4" "36.8" "43.0" "39.6" "32.5" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "8.208" "5" "3" "3" "3" "556" "63.1" "6.76" "8.80" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "7" "0" "1.144" "1.139" "0.859" "1.023" "0.771" "0.685" "0.743" "1.218" "1.175" "111.4" "127.5" "127.0" "95.8" "114.0" "85.9" "76.3" "82.8" "135.7" "130.9" "" "" "" "" "" "" "" "" "" "" "111.4" "107.9" "80.3" "69.8" "93.4" "66.7" "58.8" "71.2" "105.9" "117.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "8.197" "2" "2" "2" "1" "1050" "116.8" "7.11" "5.92" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "8.195" "9" "3" "3" "3" "354" "38.2" "5.62" "8.00" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "0.985" "0.996" "1.094" "1.027" "1.068" "1.039" "0.974" "1.206" "1.160" "76.9" "75.7" "76.6" "84.1" "78.9" "82.1" "79.8" "74.9" "92.7" "89.2" "" "" "" "" "" "" "" "" "" "" "76.9" "64.1" "48.4" "61.3" "64.7" "63.7" "61.5" "64.4" "72.3" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021225223718005983" "False" "High" "IsMasterProtein" "P31949" "Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2" "0.000" "False" "8.190" "24" "3" "3" "3" "105" "11.7" "7.12" "7.62" "3" "signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6282" "ENSG00000163191" "S100A11" "hsa:6282; P31949; Q5VTK0" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8875331277631851835" "False" "High" "IsMasterProtein" "O75113" "NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4" "0.000" "False" "8.185" "3" "3" "3" "3" "896" "100.3" "5.36" "6.64" "3" "stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf11977" "9683" "ENSG00000102921" "N4BP1" "A7MD49; hsa:9683; O75113; Q2YDX1" "" "Regulation of NF-kappa B signaling" "1" "0" "1.061" "1.017" "1.168" "1.028" "1.034" "1.093" "1.200" "0.990" "1.166" "168.1" "178.3" "171.0" "196.5" "172.8" "173.8" "183.8" "201.8" "166.4" "196.1" "" "" "" "" "" "" "" "" "" "" "168.1" "150.9" "108.1" "143.2" "141.6" "135.0" "141.7" "173.5" "129.9" "176.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.000" "True" "8.185" "10" "3" "3" "3" "265" "30.3" "5.97" "9.62" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "15" "0" "0.714" "0.810" "0.759" "0.684" "0.936" "0.701" "0.738" "0.907" "0.797" "164.6" "117.6" "133.3" "125.0" "112.6" "154.1" "115.3" "121.5" "149.2" "131.2" "" "" "" "" "" "" "" "" "" "" "164.6" "99.5" "84.3" "91.1" "92.3" "119.7" "88.9" "104.4" "116.5" "117.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.000" "False" "8.184" "1" "2" "3" "2" "1801" "199.9" "6.62" "8.23" "2" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "0.950" "0.971" "0.959" "0.990" "1.089" "1.237" "0.975" "0.860" "1.040" "30.4" "28.9" "29.6" "29.2" "30.1" "33.2" "37.7" "29.7" "26.2" "31.7" "" "" "" "" "" "" "" "" "" "" "30.4" "24.5" "18.7" "21.3" "24.7" "25.8" "29.0" "25.5" "20.4" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "8.177" "3" "3" "6" "3" "904" "100.4" "5.76" "12.54" "3" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "15" "0" "0.985" "0.996" "1.001" "0.980" "1.098" "0.872" "0.984" "1.024" "1.012" "209.7" "206.5" "208.8" "209.9" "205.5" "230.2" "182.9" "206.4" "214.7" "212.3" "" "" "" "" "" "" "" "" "" "" "209.7" "174.7" "132.0" "153.1" "168.3" "178.8" "141.0" "177.5" "167.6" "190.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841037560780449706" "False" "High" "IsMasterProtein" "O43663" "Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2" "0.000" "False" "8.174" "3" "2" "2" "1" "620" "71.6" "6.68" "7.33" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03999" "9055" "ENSG00000198901" "PRC1" "A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6" "" "RHO GTPases activate CIT" "1" "0" "1.196" "0.710" "1.139" "1.015" "0.706" "1.056" "1.055" "0.751" "1.018" "97.2" "116.2" "69.0" "110.7" "98.7" "68.7" "102.6" "102.5" "73.0" "98.9" "" "" "" "" "" "" "" "" "" "" "97.2" "98.3" "43.6" "80.7" "80.8" "53.3" "79.1" "88.1" "57.0" "88.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4634440829805379897" "False" "High" "IsMasterProtein" "Q02224" "Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2" "0.000" "False" "8.174" "1" "2" "2" "2" "2701" "316.2" "5.64" "6.99" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "1062" "ENSG00000138778" "CENPE" "A6NKY9; A8K2U7; hsa:1062; Q02224; Q4LE75" "Regulation of sister chromatid separation at the metaphase-anaphase transition" "RHO GTPases Activate Formins; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.024" "0.632" "0.959" "0.984" "0.655" "1.001" "0.966" "0.666" "0.871" "138.2" "141.5" "87.4" "132.6" "136.1" "90.6" "138.4" "133.6" "92.0" "120.4" "" "" "" "" "" "" "" "" "" "" "138.2" "119.7" "55.3" "96.7" "111.5" "70.4" "106.7" "114.9" "71.8" "108.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8347450561102329946" "False" "High" "IsMasterProtein" "Q96BZ4" "5'-3' exonuclease PLD4 OS=Homo sapiens OX=9606 GN=PLD4 PE=1 SV=2" "0.000" "False" "8.173" "4" "2" "2" "2" "506" "55.6" "8.35" "7.18" "2" "DNA metabolism;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13918" "122618" "ENSG00000166428" "PLD4" "hsa:122618; Q6UWD2; Q96BZ4" "" "Role of phospholipids in phagocytosis; Synthesis of PG; Synthesis of IP3 and IP4 in the cytosol" "3" "0" "1.127" "0.995" "0.916" "1.215" "1.002" "1.069" "1.024" "0.974" "1.073" "62.3" "70.2" "62.0" "57.1" "75.7" "62.5" "66.6" "63.8" "60.7" "66.9" "" "" "" "" "" "" "" "" "" "" "62.3" "59.4" "39.2" "41.6" "62.1" "48.5" "51.4" "54.8" "47.4" "60.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "8.164" "13" "2" "3" "2" "143" "15.8" "10.49" "10.84" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.952" "1.124" "0.984" "1.092" "1.034" "1.023" "1.149" "1.067" "0.970" "170.7" "162.4" "191.9" "167.9" "186.4" "176.4" "174.6" "196.1" "182.1" "165.5" "" "" "" "" "" "" "" "" "" "" "170.7" "137.4" "121.3" "122.4" "152.7" "137.0" "134.6" "168.6" "142.1" "148.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "8.161" "2" "2" "3" "2" "920" "96.5" "7.12" "9.87" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "0.951" "1.016" "1.049" "0.937" "0.828" "0.985" "1.091" "0.931" "1.278" "93.7" "89.2" "95.2" "98.3" "87.8" "77.6" "92.4" "102.3" "87.2" "119.8" "" "" "" "" "" "" "" "" "" "" "93.7" "75.4" "60.2" "71.7" "72.0" "60.3" "71.2" "88.0" "68.1" "107.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.000" "False" "8.141" "3" "3" "3" "3" "860" "96.2" "5.27" "8.65" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "" "Neddylation" "1" "0" "0.985" "0.864" "0.998" "0.904" "0.652" "0.789" "0.754" "1.019" "0.743" "38.7" "38.1" "33.4" "38.6" "34.9" "25.2" "30.5" "29.1" "39.4" "28.7" "" "" "" "" "" "" "" "" "" "" "38.7" "32.2" "21.1" "28.1" "28.6" "19.6" "23.5" "25.1" "30.8" "25.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "8.134" "9" "3" "4" "3" "259" "30.1" "5.34" "12.24" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "" "Neddylation" "1" "0" "0.985" "1.077" "0.887" "0.924" "0.972" "0.923" "0.962" "1.061" "1.054" "656.2" "646.1" "706.6" "582.3" "606.3" "638.1" "605.5" "631.4" "696.3" "691.8" "" "" "" "" "" "" "" "" "" "" "656.2" "546.6" "446.8" "424.6" "496.7" "495.5" "466.7" "542.9" "543.5" "622.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8847803836591392449" "False" "High" "IsMasterProtein" "A0AAG2SUK6" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.000" "False" "8.124" "15" "2" "2" "2" "153" "17.8" "9.69" "7.15" "2" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "8.119" "5" "2" "2" "2" "374" "41.7" "4.92" "7.41" "2" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "0.976" "1.086" "1.092" "1.037" "1.067" "1.155" "0.969" "1.037" "1.072" "169.2" "165.2" "183.7" "184.7" "175.5" "180.6" "195.4" "164.1" "175.6" "181.3" "" "" "" "" "" "" "" "" "" "" "169.2" "139.8" "116.2" "134.7" "143.8" "140.2" "150.6" "141.1" "137.0" "163.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "8.109" "12" "2" "2" "2" "223" "26.0" "4.98" "8.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "" "Unwinding of DNA" "1" "0" "1.084" "1.410" "1.541" "1.184" "1.309" "1.215" "1.127" "1.335" "1.267" "15.8" "17.1" "22.2" "24.3" "18.7" "20.7" "19.2" "17.8" "21.1" "20.0" "" "" "" "" "" "" "" "" "" "" "15.8" "14.5" "14.1" "17.7" "15.3" "16.0" "14.8" "15.3" "16.4" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "8.103" "6" "2" "2" "2" "438" "48.1" "7.84" "6.36" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.054" "0.858" "0.529" "0.760" "1.009" "1.208" "1.104" "1.011" "0.845" "21.6" "22.8" "18.5" "11.4" "16.4" "21.8" "26.1" "23.9" "21.9" "18.3" "" "" "" "" "" "" "" "" "" "" "21.6" "19.3" "11.7" "8.3" "13.5" "16.9" "20.1" "20.5" "17.1" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801369761430289409" "False" "High" "IsMasterProtein" "Q12968" "Nuclear factor of activated T-cells, cytoplasmic 3 OS=Homo sapiens OX=9606 GN=NFATC3 PE=1 SV=1" "0.000" "False" "8.080" "3" "3" "4" "1" "1075" "115.5" "6.37" "7.48" "3" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4775" "ENSG00000072736" "NFATC3" "hsa:4775; O75211; Q12968; Q14516; Q99840; Q99841; Q99842" "Heart development; B cell receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "10" "0" "0.918" "1.002" "1.252" "1.471" "0.966" "1.062" "1.149" "0.872" "1.188" "40.5" "37.2" "40.6" "50.7" "59.6" "39.1" "43.0" "46.6" "35.3" "48.1" "" "" "" "" "" "" "" "" "" "" "40.5" "31.5" "25.7" "37.0" "48.8" "30.4" "33.2" "40.0" "27.6" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157889275471212974" "False" "High" "IsMasterProtein" "O75317" "Ubiquitin carboxyl-terminal hydrolase 12 OS=Homo sapiens OX=9606 GN=USP12 PE=1 SV=2" "0.000" "False" "8.071" "8" "3" "3" "3" "370" "42.8" "6.60" "7.91" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "219333" "ENSG00000152484" "USP12" "A8K0X0; hsa:219333; O75317; Q5VZV3; Q8TC49" "" "Ub-specific processing proteases" "1" "0" "0.979" "1.095" "1.151" "1.163" "0.988" "1.032" "1.037" "1.062" "0.992" "90.5" "88.6" "99.2" "104.2" "105.3" "89.4" "93.5" "93.9" "96.1" "89.8" "" "" "" "" "" "" "" "" "" "" "90.5" "75.0" "62.7" "76.0" "86.3" "69.4" "72.0" "80.7" "75.0" "80.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "8.071" "9" "2" "2" "2" "361" "41.2" "4.78" "6.70" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "HDAC6 interactions in the central nervous system" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "3" "0" "1.388" "1.189" "1.125" "1.104" "1.304" "1.282" "1.173" "1.220" "0.950" "41.7" "58.0" "49.6" "46.9" "46.1" "54.4" "53.5" "49.0" "50.9" "39.6" "" "" "" "" "" "" "" "" "" "" "41.7" "49.0" "31.4" "34.2" "37.8" "42.3" "41.3" "42.1" "39.7" "35.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494734003636031426" "False" "High" "IsMasterProtein" "Q8N2Z9" "Centromere protein S OS=Homo sapiens OX=9606 GN=CENPS PE=1 SV=1" "0.000" "False" "8.058" "15" "2" "2" "2" "138" "15.9" "6.05" "5.08" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15630" "100526739; 378708" "ENSG00000175279" "CENPS" "hsa:100526739; hsa:378708; Q8N2Z9; Q8NFE5; Q8NFG5" "DNA repair pathways, full network" "Fanconi Anemia Pathway; Separation of Sister Chromatids; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.134" "0.898" "1.138" "1.200" "1.449" "1.312" "1.122" "1.420" "0.980" "25.7" "29.2" "23.1" "29.3" "30.9" "37.3" "33.7" "28.9" "36.5" "25.2" "" "" "" "" "" "" "" "" "" "" "25.7" "24.7" "14.6" "21.3" "25.3" "28.9" "26.0" "24.8" "28.5" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "8.046" "2" "3" "3" "3" "2214" "248.3" "5.55" "5.99" "3" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "" "Amyloid fiber formation" "1" "0" "1.178" "0.997" "1.106" "1.076" "1.076" "0.964" "1.194" "1.028" "1.093" "53.0" "62.5" "52.9" "58.6" "57.1" "57.0" "51.1" "63.3" "54.5" "57.9" "" "" "" "" "" "" "" "" "" "" "53.0" "52.8" "33.4" "42.8" "46.7" "44.3" "39.4" "54.4" "42.5" "52.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "8.046" "3" "2" "2" "2" "916" "103.6" "9.04" "6.83" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "" "mRNA Splicing - Major Pathway" "1" "0" "1.025" "1.147" "1.028" "1.199" "1.418" "0.780" "1.214" "1.253" "1.139" "46.6" "47.7" "53.4" "47.9" "55.9" "66.1" "36.4" "56.6" "58.4" "53.1" "" "" "" "" "" "" "" "" "" "" "46.6" "40.4" "33.8" "34.9" "45.8" "51.3" "28.0" "48.6" "45.6" "47.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7557480247223307302" "False" "High" "IsMasterProtein" "O94806" "Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1" "0.000" "False" "8.038" "2" "2" "2" "1" "890" "100.4" "6.87" "6.71" "2" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "23683" "ENSG00000115825" "PRKD3" "D6W587; hsa:23683; O94806; Q53TR7; Q8NEL8" "G protein signaling pathways; Hippo signaling regulation pathways; Chronic hyperglycemia impairment of neuron function" "Sphingolipid de novo biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020572113107876671" "False" "High" "IsMasterProtein" "Q13643" "Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4" "0.000" "False" "8.034" "9" "3" "3" "3" "280" "31.2" "6.20" "10.08" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "2275" "ENSG00000183386" "FHL3" "D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2" "" "" "0" "0" "0.970" "0.926" "0.854" "1.069" "1.005" "1.115" "1.011" "0.994" "0.986" "345.1" "334.7" "319.6" "294.6" "368.8" "346.8" "384.8" "348.9" "343.1" "340.3" "" "" "" "" "" "" "" "" "" "" "345.1" "283.2" "202.1" "214.8" "302.2" "269.3" "296.6" "300.0" "267.8" "305.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1136276274869286846" "False" "High" "IsMasterProtein" "Q9NVR2" "Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2" "0.000" "False" "8.016" "4" "3" "3" "3" "710" "82.2" "7.44" "8.58" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf21045" "55174" "ENSG00000104613" "INTS10" "hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.201" "1.005" "1.140" "1.372" "0.969" "1.135" "1.034" "1.080" "1.183" "154.7" "185.8" "155.5" "176.3" "212.2" "149.9" "175.5" "160.0" "167.1" "183.0" "" "" "" "" "" "" "" "" "" "" "154.7" "157.2" "98.3" "128.6" "173.9" "116.4" "135.3" "137.6" "130.4" "164.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "8.007" "15" "4" "5" "2" "207" "22.0" "9.38" "13.47" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "1.030" "1.217" "1.046" "0.999" "1.084" "1.002" "1.030" "1.059" "1.090" "247.6" "255.1" "301.3" "259.1" "247.5" "268.3" "248.1" "254.9" "262.1" "269.8" "" "" "" "" "" "" "" "" "" "" "247.6" "215.9" "190.5" "188.9" "202.7" "208.4" "191.2" "219.2" "204.6" "242.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1676196401690922659" "False" "High" "IsMasterProtein" "Q8WUZ0" "B-cell CLL/lymphoma 7 protein family member C OS=Homo sapiens OX=9606 GN=BCL7C PE=1 SV=3" "0.000" "False" "7.999" "10" "2" "3" "1" "217" "23.5" "5.20" "10.03" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "9274" "ENSG00000099385" "BCL7C" "hsa:9274; O43770; Q6PD89; Q8WUZ0" "" "" "0" "0" "0.795" "0.735" "0.854" "0.830" "0.825" "0.957" "1.046" "0.812" "0.833" "61.9" "49.2" "45.5" "52.9" "51.4" "51.1" "59.3" "64.8" "50.3" "51.6" "" "" "" "" "" "" "" "" "" "" "61.9" "41.7" "28.8" "38.5" "42.1" "39.7" "45.7" "55.7" "39.3" "46.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "7.996" "15" "3" "4" "3" "160" "18.3" "6.30" "9.39" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "1.049" "0.916" "1.017" "1.072" "0.925" "1.037" "0.950" "0.974" "1.060" "465.3" "488.1" "426.2" "473.4" "498.7" "430.6" "482.5" "442.3" "453.1" "493.1" "" "" "" "" "" "" "" "" "" "" "465.3" "413.0" "269.5" "345.2" "408.6" "334.4" "371.9" "380.3" "353.7" "443.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178274936049826083" "False" "High" "IsMasterProtein" "Q9Y2S2" "Lambda-crystallin homolog OS=Homo sapiens OX=9606 GN=CRYL1 PE=1 SV=3" "0.000" "False" "7.992" "6" "2" "2" "2" "319" "35.4" "6.18" "7.40" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00725, Pf02737" "51084" "ENSG00000165475" "CRYL1" "A0PJ43; B3KN92; hsa:51084; Q0VDI1; Q7Z4Z9; Q9P0G7; Q9Y2S2" "13q12 or CRYL1 copy number variation" "Formation of xylulose-5-phosphate" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-930823423680918184" "False" "High" "IsMasterProtein" "Q53H82" "Endoribonuclease LACTB2 OS=Homo sapiens OX=9606 GN=LACTB2 PE=1 SV=2" "0.000" "False" "7.976" "6" "2" "2" "2" "288" "32.8" "6.80" "6.90" "2" "" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00753, Pf17778" "51110" "ENSG00000147592" "LACTB2" "A8K2D6; hsa:51110; Q53H82; Q9Y392" "" "" "0" "0" "0.836" "0.983" "0.892" "0.872" "0.860" "0.819" "0.960" "0.788" "0.856" "117.5" "98.2" "115.5" "104.8" "102.4" "101.0" "96.2" "112.8" "92.6" "100.5" "" "" "" "" "" "" "" "" "" "" "117.5" "83.1" "73.1" "76.4" "83.9" "78.5" "74.1" "97.0" "72.3" "90.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.000" "False" "7.976" "20" "2" "2" "2" "110" "11.3" "6.54" "6.21" "2" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "" "Antimicrobial peptides" "1" "0" "0.984" "0.661" "1.375" "1.616" "0.966" "0.551" "0.872" "0.933" "0.554" "103.8" "102.2" "68.6" "142.7" "167.7" "100.3" "57.2" "90.5" "96.9" "57.6" "" "" "" "" "" "" "" "" "" "" "103.8" "86.5" "43.4" "104.1" "137.4" "77.9" "44.1" "77.8" "75.6" "51.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.000" "False" "7.965" "18" "3" "3" "3" "149" "17.4" "10.86" "8.67" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "1p36 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.924" "0.833" "0.798" "1.096" "0.781" "0.879" "0.825" "0.981" "0.888" "104.8" "96.8" "87.2" "83.7" "114.8" "81.8" "92.1" "86.5" "102.8" "93.0" "" "" "" "" "" "" "" "" "" "" "104.8" "81.9" "55.2" "61.0" "94.1" "63.5" "71.0" "74.3" "80.3" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "7.962" "29" "4" "5" "3" "103" "11.6" "5.27" "13.51" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.937" "1.150" "0.887" "0.999" "1.286" "1.157" "1.003" "1.195" "1.044" "445.8" "417.7" "512.8" "395.3" "445.3" "573.5" "515.9" "447.1" "532.6" "465.6" "" "" "" "" "" "" "" "" "" "" "445.8" "353.4" "324.3" "288.2" "364.8" "445.4" "397.7" "384.4" "415.7" "418.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6060199477949358472" "False" "High" "IsMasterProtein" "Q9Y6X5" "Bis(5'-adenosyl)-triphosphatase ENPP4 OS=Homo sapiens OX=9606 GN=ENPP4 PE=1 SV=3" "0.000" "False" "7.952" "5" "2" "2" "2" "453" "51.6" "6.15" "5.70" "2" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf01663" "22875" "ENSG00000001561" "ENPP4" "A8K5G1; hsa:22875; Q7L2N1; Q9Y6X5" "" "Neutrophil degranulation" "1" "0" "0.869" "0.876" "1.417" "1.385" "1.428" "1.201" "1.275" "1.446" "1.134" "21.1" "18.3" "18.5" "29.9" "29.3" "30.2" "25.4" "26.9" "30.6" "24.0" "" "" "" "" "" "" "" "" "" "" "21.1" "15.5" "11.7" "21.8" "24.0" "23.4" "19.6" "23.2" "23.8" "21.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "7.946" "12" "3" "4" "1" "226" "22.6" "10.92" "10.42" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "0.895" "0.766" "0.922" "0.994" "0.832" "0.939" "1.120" "0.767" "1.017" "182.6" "163.4" "139.9" "168.4" "181.5" "152.0" "171.5" "204.5" "140.1" "185.8" "" "" "" "" "" "" "" "" "" "" "182.6" "138.2" "88.4" "122.8" "148.7" "118.0" "132.2" "175.8" "109.4" "167.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2746041825889845794" "False" "High" "IsMasterProtein" "Q15059" "Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1" "0.000" "False" "7.944" "4" "3" "3" "1" "726" "79.5" "9.36" "7.77" "3" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00439, Pf17035" "8019" "ENSG00000169925" "BRD3" "B1APD9; hsa:8019; Q15059; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "High" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.000" "False" "7.941" "5" "1" "2" "1" "205" "24.2" "10.39" "7.65" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3562387644317083347" "False" "High" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "0.000" "False" "7.936" "1" "3" "3" "3" "2202" "251.3" "7.09" "8.83" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "0.979" "0.988" "1.030" "1.013" "0.930" "1.012" "0.930" "1.032" "1.119" "107.2" "104.9" "105.8" "110.4" "108.5" "99.7" "108.4" "99.6" "110.6" "119.9" "" "" "" "" "" "" "" "" "" "" "107.2" "88.8" "66.9" "80.5" "88.9" "77.4" "83.6" "85.7" "86.3" "107.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "7.933" "8" "2" "2" "2" "293" "34.2" "9.88" "6.89" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "0.977" "0.987" "1.038" "0.919" "0.940" "0.960" "0.928" "0.843" "0.974" "226.1" "220.7" "223.1" "234.6" "207.7" "212.5" "217.1" "209.8" "190.7" "220.2" "" "" "" "" "" "" "" "" "" "" "226.1" "186.8" "141.1" "171.0" "170.2" "165.0" "167.3" "180.4" "148.8" "197.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2041332710814858625" "False" "High" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "0.000" "False" "7.932" "2" "3" "3" "3" "1499" "170.4" "6.64" "8.97" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "Focal adhesion; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "18" "0" "1.159" "0.972" "1.134" "1.148" "1.017" "1.156" "1.077" "1.030" "1.157" "183.0" "212.0" "177.8" "207.6" "210.2" "186.1" "211.7" "197.1" "188.5" "211.8" "" "" "" "" "" "" "" "" "" "" "183.0" "179.4" "112.4" "151.4" "172.2" "144.5" "163.1" "169.5" "147.2" "190.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040602984972190355" "False" "High" "IsMasterProtein" "Q9Y259" "Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3" "0.000" "False" "7.927" "5" "3" "3" "3" "395" "45.2" "5.49" "7.66" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1120" "ENSG00000100288" "CHKB" "A0PJM6; hsa:1120; Q13388; Q9Y259" "Fatty acid beta-oxidation; Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PC; Synthesis of PE" "7" "0" "1.281" "1.360" "1.499" "1.449" "1.227" "1.483" "1.190" "1.319" "1.468" "31.5" "40.3" "42.8" "47.2" "45.6" "38.6" "46.7" "37.5" "41.5" "46.2" "" "" "" "" "" "" "" "" "" "" "31.5" "34.1" "27.1" "34.4" "37.4" "30.0" "36.0" "32.2" "32.4" "41.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "7.926" "11" "3" "3" "3" "368" "41.7" "6.39" "6.47" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "0.971" "1.086" "1.140" "1.019" "1.035" "1.224" "0.924" "1.067" "0.926" "62.3" "60.5" "67.7" "71.0" "63.4" "64.4" "76.3" "57.5" "66.4" "57.7" "" "" "" "" "" "" "" "" "" "" "62.3" "51.2" "42.8" "51.8" "52.0" "50.0" "58.8" "49.5" "51.9" "51.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589862746651834702" "False" "High" "IsMasterProtein" "Q9UBW5" "Bridging integrator 2 OS=Homo sapiens OX=9606 GN=BIN2 PE=1 SV=3" "0.000" "False" "7.912" "4" "2" "2" "2" "565" "61.8" "5.15" "6.91" "2" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf03114, Pf21532" "51411" "ENSG00000110934" "BIN2" "B7Z6F3; F5H0W4; hsa:51411; Q86VV0; Q9NWK4; Q9UBW5; Q9UKN4" "TYROBP causal network in microglia" "Neutrophil degranulation; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "3" "0" "0.987" "1.059" "1.138" "1.067" "1.343" "1.079" "1.132" "1.202" "1.105" "143.9" "142.1" "152.4" "163.8" "153.6" "193.3" "155.2" "162.8" "173.0" "159.0" "" "" "" "" "" "" "" "" "" "" "143.9" "120.2" "96.4" "119.4" "125.8" "150.1" "119.7" "140.0" "135.0" "143.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "7.907" "3" "2" "2" "2" "744" "82.3" "7.78" "5.52" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.336" "1.276" "1.137" "0.946" "1.265" "1.632" "1.342" "1.307" "0.836" "10.7" "14.3" "13.6" "12.2" "10.1" "13.5" "17.5" "14.3" "14.0" "8.9" "" "" "" "" "" "" "" "" "" "" "10.7" "12.1" "8.6" "8.9" "8.3" "10.5" "13.5" "12.3" "10.9" "8.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "7.895" "8" "1" "3" "1" "185" "21.4" "5.44" "8.12" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "" "Unwinding of DNA" "1" "0" "1.032" "0.783" "1.271" "1.275" "1.126" "1.293" "0.992" "1.024" "1.029" "50.9" "52.5" "39.8" "64.7" "64.9" "57.3" "65.8" "50.5" "52.2" "52.4" "" "" "" "" "" "" "" "" "" "" "50.9" "44.5" "25.2" "47.2" "53.2" "44.5" "50.7" "43.4" "40.7" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "7.893" "4" "4" "4" "4" "739" "83.3" "6.70" "9.83" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "4p16.3 copy number variation" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "3" "0" "0.961" "1.167" "0.986" "0.989" "1.141" "1.145" "1.034" "1.129" "1.122" "414.4" "398.3" "483.7" "408.7" "409.7" "472.6" "474.7" "428.4" "468.0" "465.1" "" "" "" "" "" "" "" "" "" "" "414.4" "336.9" "305.8" "298.0" "335.7" "367.0" "365.9" "368.3" "365.3" "418.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4826507384630182713" "False" "High" "IsMasterProtein" "Q96IZ7" "Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1" "0.000" "False" "7.892" "7" "2" "2" "2" "334" "38.7" "11.08" "7.70" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "" "" "51319" "ENSG00000174891" "RSRC1" "A8K2R9; hsa:51319; Q96IZ7; Q96QK2; Q9NZE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.000" "False" "7.885" "13" "2" "3" "2" "163" "18.8" "4.35" "7.99" "2" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Ciliopathies" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "2" "0" "0.983" "0.817" "0.784" "0.824" "0.915" "0.860" "0.910" "0.710" "0.684" "39.3" "38.7" "32.1" "30.8" "32.4" "36.0" "33.8" "35.8" "27.9" "26.9" "" "" "" "" "" "" "" "" "" "" "39.3" "32.7" "20.3" "22.5" "26.6" "28.0" "26.1" "30.8" "21.8" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.000" "False" "7.885" "23" "2" "3" "2" "118" "13.5" "10.21" "8.78" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.869" "1.108" "1.141" "0.996" "1.017" "0.997" "1.060" "1.154" "0.971" "62.0" "53.9" "68.7" "70.8" "61.8" "63.1" "61.8" "65.7" "71.6" "60.3" "" "" "" "" "" "" "" "" "" "" "62.0" "45.6" "43.4" "51.6" "50.6" "49.0" "47.7" "56.5" "55.9" "54.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "7.874" "25" "2" "3" "2" "68" "7.7" "8.18" "10.99" "2" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "" "Mitochondrial protein import" "1" "0" "1.319" "1.185" "1.228" "1.297" "1.180" "1.371" "1.198" "1.055" "1.091" "128.8" "169.8" "152.6" "158.2" "167.1" "151.9" "176.6" "154.3" "135.9" "140.5" "" "" "" "" "" "" "" "" "" "" "128.8" "143.7" "96.5" "115.4" "136.9" "118.0" "136.1" "132.7" "106.1" "126.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6374027858147592096" "False" "High" "IsMasterProtein" "O95613" "Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4" "0.000" "False" "7.873" "1" "2" "2" "2" "3336" "377.8" "5.55" "6.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf10495" "5116" "ENSG00000160299" "PCNT" "hsa:5116; O43152; O95613; Q7Z7C9" "" "Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy" "10" "0" "1.115" "0.907" "1.120" "1.148" "0.883" "1.257" "1.131" "1.021" "1.042" "148.7" "165.8" "134.9" "166.5" "170.6" "131.3" "186.9" "168.2" "151.9" "155.0" "" "" "" "" "" "" "" "" "" "" "148.7" "140.2" "85.3" "121.4" "139.8" "102.0" "144.1" "144.6" "118.5" "139.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.000" "False" "7.864" "3" "2" "2" "2" "671" "74.6" "9.26" "5.30" "2" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "1.354" "1.059" "1.817" "1.877" "2.062" "1.278" "2.026" "1.278" "1.458" "11.6" "15.7" "12.3" "21.1" "21.8" "23.9" "14.8" "23.5" "14.8" "16.9" "" "" "" "" "" "" "" "" "" "" "11.6" "13.3" "7.8" "15.4" "17.9" "18.6" "11.4" "20.2" "11.6" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "7.852" "4" "2" "3" "2" "524" "51.4" "12.41" "9.51" "2" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "0.876" "0.862" "1.009" "0.967" "0.853" "1.024" "1.040" "0.841" "0.945" "227.6" "199.3" "196.2" "229.7" "220.0" "194.2" "233.2" "236.7" "191.3" "215.1" "" "" "" "" "" "" "" "" "" "" "227.6" "168.6" "124.0" "167.5" "180.2" "150.8" "179.7" "203.5" "149.3" "193.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "7.848" "3" "3" "3" "3" "788" "86.7" "9.42" "8.82" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "7" "0" "1.198" "1.255" "1.422" "1.479" "1.096" "1.453" "1.400" "1.193" "1.063" "50.6" "60.7" "63.5" "72.0" "74.9" "55.5" "73.6" "70.9" "60.4" "53.8" "" "" "" "" "" "" "" "" "" "" "50.6" "51.3" "40.2" "52.5" "61.4" "43.1" "56.7" "61.0" "47.2" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.000" "False" "7.840" "3" "3" "4" "2" "794" "89.5" "6.79" "10.45" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.957" "1.077" "1.011" "1.076" "1.087" "1.039" "1.177" "1.067" "1.077" "155.4" "148.8" "167.4" "157.1" "167.3" "168.9" "161.5" "183.0" "165.8" "167.4" "" "" "" "" "" "" "" "" "" "" "155.4" "125.9" "105.9" "114.6" "137.0" "131.2" "124.5" "157.3" "129.4" "150.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "7.839" "18" "2" "2" "2" "100" "11.4" "7.34" "7.58" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "8" "0" "1.049" "1.091" "1.220" "1.157" "1.139" "1.314" "1.122" "1.042" "1.148" "164.5" "172.7" "179.6" "200.7" "190.3" "187.4" "216.2" "184.7" "171.4" "188.9" "" "" "" "" "" "" "" "" "" "" "164.5" "146.1" "113.5" "146.3" "155.9" "145.6" "166.6" "158.8" "133.8" "169.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387955691257056682" "False" "High" "IsMasterProtein" "O43318" "Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1" "0.000" "False" "7.836" "3" "2" "2" "2" "606" "67.2" "7.11" "7.23" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "6885" "ENSG00000135341" "MAP3K7" "B2RE27; E1P523; hsa:6885; O43317; O43318; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNA role in immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "50" "0" "1.067" "0.785" "1.101" "0.978" "0.898" "1.029" "1.073" "0.925" "0.998" "202.8" "216.3" "159.2" "223.2" "198.2" "182.0" "208.6" "217.5" "187.5" "202.3" "" "" "" "" "" "" "" "" "" "" "202.8" "183.0" "100.7" "162.8" "162.4" "141.3" "160.8" "187.0" "146.3" "181.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824076810458492012" "False" "High" "IsMasterProtein" "P05165" "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" "0.000" "False" "7.828" "4" "3" "3" "3" "728" "80.0" "7.52" "7.49" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786, Pf18140" "5095" "ENSG00000175198" "PCCA" "B4DKY8; B4DPF9; C9JPQ8; hsa:5095; P05165; Q15979; Q8WXQ7" "Primary ovarian insufficiency" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "4" "0" "1.007" "1.096" "0.949" "1.021" "1.053" "0.831" "0.894" "1.033" "0.833" "126.3" "127.2" "138.5" "119.9" "129.0" "132.9" "105.0" "112.9" "130.4" "105.2" "" "" "" "" "" "" "" "" "" "" "126.3" "107.6" "87.5" "87.4" "105.7" "103.2" "80.9" "97.0" "101.8" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3995603134814959224" "False" "High" "IsMasterProtein" "Q9NRL2" "Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2" "0.000" "False" "7.821" "2" "3" "3" "3" "1556" "178.6" "6.60" "8.09" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613" "11177" "ENSG00000198604" "BAZ1A" "hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3" "Ectoderm differentiation" "" "1" "0" "1.042" "0.735" "0.920" "1.001" "0.860" "1.031" "0.892" "0.820" "0.883" "165.8" "172.8" "121.9" "152.5" "166.0" "142.6" "170.9" "147.9" "136.0" "146.4" "" "" "" "" "" "" "" "" "" "" "165.8" "146.2" "77.1" "111.2" "136.0" "110.7" "131.8" "127.2" "106.2" "131.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.000" "False" "7.821" "9" "3" "4" "3" "309" "33.8" "6.04" "11.95" "3" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "Pyrimidine metabolism" "" "1" "0" "1.125" "1.050" "1.231" "1.074" "1.098" "1.186" "1.028" "1.076" "1.142" "284.4" "320.1" "298.7" "350.0" "305.3" "312.3" "337.4" "292.3" "306.1" "324.8" "" "" "" "" "" "" "" "" "" "" "284.4" "270.8" "188.9" "255.2" "250.2" "242.5" "260.1" "251.3" "239.0" "292.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "7.810" "10" "2" "2" "2" "272" "28.2" "5.54" "4.71" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "7.807" "11" "3" "4" "3" "271" "29.8" "5.74" "10.78" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "59" "0" "0.688" "0.983" "0.873" "0.827" "0.977" "0.910" "0.944" "0.963" "0.845" "92.1" "63.4" "90.6" "80.5" "76.2" "90.1" "83.9" "87.0" "88.7" "77.9" "" "" "" "" "" "" "" "" "" "" "92.1" "53.6" "57.3" "58.7" "62.4" "69.9" "64.7" "74.8" "69.3" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "7.807" "8" "2" "6" "2" "210" "22.3" "6.40" "14.50" "2" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "" "Cytosolic sulfonation of small molecules" "1" "0" "1.018" "1.156" "1.027" "1.100" "1.185" "0.975" "1.064" "1.203" "1.130" "459.4" "467.6" "531.2" "471.8" "505.4" "544.6" "448.1" "488.6" "552.7" "519.3" "" "" "" "" "" "" "" "" "" "" "459.4" "395.6" "335.9" "344.0" "414.1" "422.9" "345.4" "420.1" "431.4" "466.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8573575756283577734" "False" "High" "IsMasterProtein" "Q8TEH3" "DENN domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DENND1A PE=1 SV=2" "0.000" "False" "7.799" "2" "2" "3" "2" "1009" "110.5" "6.96" "8.93" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "57706" "ENSG00000119522" "DENND1A" "A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; hsa:57706; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q8TEH3; Q9H796" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.098" "1.484" "0.790" "1.582" "1.410" "1.348" "1.341" "1.666" "1.251" "14.6" "16.1" "21.7" "11.6" "23.2" "20.7" "19.8" "19.6" "24.4" "18.3" "" "" "" "" "" "" "" "" "" "" "14.6" "13.6" "13.7" "8.4" "19.0" "16.0" "15.2" "16.9" "19.1" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767729618822811067" "False" "High" "IsMasterProtein" "O14933" "Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4" "0.000" "False" "7.798" "10" "1" "5" "1" "153" "17.8" "7.88" "15.87" "1" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "9246" "ENSG00000156587" "UBE2L6" "A6NDM6; A8MY53; hsa:9246; O14933; Q8N5D8; Q9UEZ0" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; RSV-host interactions; Amyloid fiber formation; PKR-mediated signaling; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "11" "0" "1.231" "0.902" "1.061" "1.217" "0.910" "1.124" "1.165" "0.894" "1.246" "71.2" "87.7" "64.2" "75.5" "86.6" "64.8" "80.0" "83.0" "63.7" "88.7" "" "" "" "" "" "" "" "" "" "" "71.2" "74.2" "40.6" "55.1" "71.0" "50.3" "61.7" "71.3" "49.7" "79.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "7.796" "11" "2" "2" "2" "157" "18.2" "7.59" "6.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "" "Transcriptional Regulation by E2F6" "1" "0" "1.309" "0.989" "1.427" "1.178" "1.010" "1.317" "1.304" "1.200" "1.275" "48.8" "63.9" "48.3" "69.7" "57.5" "49.3" "64.3" "63.7" "58.6" "62.3" "" "" "" "" "" "" "" "" "" "" "48.8" "54.1" "30.6" "50.8" "47.1" "38.3" "49.6" "54.7" "45.7" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-739436223450923494" "False" "High" "IsMasterProtein" "P28749" "Retinoblastoma-like protein 1 OS=Homo sapiens OX=9606 GN=RBL1 PE=1 SV=3" "0.000" "False" "7.793" "3" "3" "3" "3" "1068" "120.8" "7.50" "7.33" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5933" "ENSG00000080839" "RBL1" "A8K2W5; hsa:5933; P28749; Q4VXA0; Q8N5K6; Q9H1L5; Q9H1M1" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "13" "0" "0.815" "1.019" "1.123" "1.232" "0.889" "1.028" "1.145" "0.911" "1.106" "20.5" "16.7" "20.9" "23.0" "25.3" "18.2" "21.1" "23.5" "18.7" "22.7" "" "" "" "" "" "" "" "" "" "" "20.5" "14.2" "13.2" "16.8" "20.7" "14.2" "16.3" "20.2" "14.6" "20.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.000" "False" "7.792" "3" "3" "3" "3" "1085" "122.3" "6.47" "9.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.041" "0.664" "1.019" "1.023" "0.689" "1.056" "1.123" "0.594" "1.017" "260.9" "271.6" "173.3" "266.0" "266.9" "179.7" "275.6" "292.9" "155.1" "265.3" "" "" "" "" "" "" "" "" "" "" "260.9" "229.8" "109.6" "193.9" "218.7" "139.6" "212.5" "251.9" "121.1" "238.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "High" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.000" "False" "7.782" "6" "2" "2" "2" "339" "39.7" "7.65" "5.70" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "7.781" "5" "1" "3" "1" "168" "17.5" "5.49" "11.43" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.824" "1.074" "0.968" "1.036" "0.994" "1.019" "1.044" "1.115" "1.008" "171.8" "141.5" "184.6" "166.3" "178.1" "170.7" "175.1" "179.4" "191.6" "173.3" "" "" "" "" "" "" "" "" "" "" "171.8" "119.8" "116.7" "121.2" "145.9" "132.6" "135.0" "154.3" "149.6" "155.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5389822382155894412" "False" "High" "IsMasterProtein" "Q15223" "Nectin-1 OS=Homo sapiens OX=9606 GN=NECTIN1 PE=1 SV=3" "0.000" "False" "7.758" "4" "2" "2" "2" "517" "57.1" "6.10" "7.98" "2" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686, Pf08205, Pf13927" "5818" "ENSG00000110400" "NECTIN1" "hsa:5818; O75465; Q15223; Q2M3D3; Q9HBE6; Q9HBW2" "" "Nectin/Necl trans heterodimerization" "2" "0" "1.099" "0.932" "1.091" "0.932" "0.902" "1.017" "1.118" "0.859" "0.880" "117.2" "128.9" "109.2" "127.9" "109.2" "105.8" "119.2" "131.1" "100.6" "103.2" "" "" "" "" "" "" "" "" "" "" "117.2" "109.0" "69.1" "93.3" "89.5" "82.1" "91.9" "112.7" "78.6" "92.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "7.753" "1" "2" "2" "2" "1231" "139.9" "5.35" "6.63" "2" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "Ciliary landscape" "" "1" "0" "1.059" "0.881" "1.165" "1.145" "0.896" "1.256" "1.246" "1.017" "0.959" "189.8" "201.0" "167.3" "221.1" "217.4" "170.0" "238.4" "236.4" "193.0" "181.9" "" "" "" "" "" "" "" "" "" "" "189.8" "170.0" "105.8" "161.2" "178.1" "132.0" "183.7" "203.3" "150.7" "163.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "High" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.000" "False" "7.735" "2" "2" "2" "2" "1066" "122.5" "5.24" "7.36" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "7.724" "16" "3" "3" "2" "158" "17.3" "6.35" "8.66" "3" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "1.035" "0.885" "0.976" "1.003" "0.853" "1.188" "0.967" "0.828" "1.027" "85.3" "88.3" "75.5" "83.3" "85.5" "72.8" "101.3" "82.5" "70.6" "87.6" "" "" "" "" "" "" "" "" "" "" "85.3" "74.7" "47.7" "60.7" "70.1" "56.5" "78.1" "71.0" "55.1" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7264395322286508547" "False" "High" "IsMasterProtein" "Q6ZS11" "Ras and Rab interactor-like protein OS=Homo sapiens OX=9606 GN=RINL PE=1 SV=2" "0.000" "False" "7.722" "2" "1" "2" "1" "566" "62.4" "5.92" "7.17" "1" "transport" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02204" "126432" "ENSG00000187994; ENSG00000282895" "RINL" "B4DPG5; hsa:126432; Q6ZS11" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.991" "1.262" "1.117" "1.207" "1.136" "1.245" "1.143" "1.186" "0.945" "56.6" "56.1" "71.4" "63.2" "68.3" "64.2" "70.5" "64.6" "67.1" "53.5" "" "" "" "" "" "" "" "" "" "" "56.6" "47.4" "45.1" "46.1" "55.9" "49.9" "54.3" "55.6" "52.4" "48.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7820090330366172225" "False" "High" "IsMasterProtein" "Cont_Q7RTS7" "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" "0.000" "True" "7.705" "5" "3" "5" "1" "529" "57.8" "7.71" "13.79" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208" "121391" "ENSG00000170484" "KRT74" "B5MD61; hsa:121391; Q7RTS7; Q86Y45" "" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "7.701" "11" "2" "2" "2" "242" "24.1" "7.09" "7.07" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.046" "1.255" "1.076" "1.048" "1.058" "1.326" "1.145" "1.005" "1.023" "52.6" "55.0" "66.0" "56.5" "55.1" "55.6" "69.7" "60.2" "52.8" "53.8" "" "" "" "" "" "" "" "" "" "" "52.6" "46.5" "41.7" "41.2" "45.1" "43.2" "53.7" "51.7" "41.2" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5710815529521285644" "False" "High" "IsMasterProtein" "Q9BQ70" "Ribosome quality control complex subunit TCF25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1" "0.000" "False" "7.700" "3" "2" "2" "2" "676" "76.6" "6.35" "5.24" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04910" "22980" "ENSG00000141002" "TCF25" "hsa:22980; Q2MK75; Q9BQ70; Q9UPV3" "" "" "0" "0" "0.897" "0.595" "0.931" "1.071" "0.629" "0.968" "0.867" "0.558" "0.679" "98.7" "88.5" "58.7" "91.9" "105.7" "62.0" "95.5" "85.6" "55.0" "67.0" "" "" "" "" "" "" "" "" "" "" "98.7" "74.9" "37.1" "67.0" "86.6" "48.2" "73.6" "73.6" "43.0" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "7.690" "5" "2" "3" "2" "489" "52.1" "5.53" "9.73" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "" "Synthesis of diphthamide-EEF2" "1" "0" "0.927" "0.853" "1.043" "1.055" "0.932" "1.043" "1.077" "0.790" "1.000" "184.8" "171.4" "157.6" "192.8" "194.9" "172.2" "192.8" "199.0" "146.0" "184.8" "" "" "" "" "" "" "" "" "" "" "184.8" "145.0" "99.6" "140.6" "159.7" "133.7" "148.6" "171.1" "114.0" "166.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787023427386069087" "False" "High" "IsMasterProtein" "P53365" "Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1" "0.000" "False" "7.684" "5" "2" "4" "1" "341" "37.8" "6.04" "12.28" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06456" "23647" "ENSG00000132254" "ARFIP2" "B4DX86; B4E306; D3DQT5; hsa:23647; P53365" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.062" "0.890" "1.126" "1.076" "0.910" "1.059" "1.032" "0.909" "1.029" "214.8" "228.1" "191.0" "241.8" "231.1" "195.5" "227.4" "221.6" "195.2" "221.0" "" "" "" "" "" "" "" "" "" "" "214.8" "193.0" "120.8" "176.3" "189.3" "151.8" "175.3" "190.6" "152.4" "198.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "7.681" "1" "1" "1" "1" "1099" "120.6" "8.75" "4.72" "1" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.027" "0.852" "1.097" "0.972" "0.968" "1.048" "1.138" "0.791" "1.008" "98.7" "101.4" "84.0" "108.3" "95.9" "95.5" "103.4" "112.3" "78.0" "99.5" "" "" "" "" "" "" "" "" "" "" "98.7" "85.7" "53.1" "78.9" "78.6" "74.1" "79.7" "96.5" "60.9" "89.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "7.679" "4" "2" "2" "2" "424" "46.6" "8.51" "6.29" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "Mesodermal commitment pathway" "HATs acetylate histones" "2" "0" "0.929" "0.814" "1.012" "1.031" "0.908" "1.038" "0.946" "0.871" "0.919" "108.0" "100.3" "87.9" "109.3" "111.3" "98.0" "112.0" "102.1" "94.1" "99.3" "" "" "" "" "" "" "" "" "" "" "108.0" "84.8" "55.6" "79.7" "91.2" "76.1" "86.4" "87.8" "73.4" "89.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8193336255424769444" "False" "High" "IsMasterProtein" "Q92845" "Kinesin-associated protein 3 OS=Homo sapiens OX=9606 GN=KIFAP3 PE=1 SV=2" "0.000" "False" "7.663" "2" "2" "3" "1" "792" "91.1" "5.08" "8.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05804" "22920" "ENSG00000075945" "KIFAP3" "B1AKU4; B1AKU5; B2RDL1; B7Z8A3; F5H591; hsa:22920; Q8NHU7; Q92845; Q9H416" "Genes related to primary cilium development (based on CRISPR)" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport" "6" "0" "1.307" "1.045" "1.147" "1.025" "0.990" "1.216" "1.420" "0.962" "0.938" "41.3" "54.0" "43.1" "47.4" "42.3" "40.9" "50.2" "58.6" "39.7" "38.7" "" "" "" "" "" "" "" "" "" "" "41.3" "45.7" "27.3" "34.5" "34.7" "31.7" "38.7" "50.4" "31.0" "34.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "7.651" "13" "3" "3" "3" "199" "21.8" "7.31" "8.00" "3" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "" "Neddylation" "1" "0" "0.911" "0.877" "1.104" "1.062" "0.815" "1.032" "0.987" "0.881" "1.031" "55.5" "50.6" "48.7" "61.3" "58.9" "45.2" "57.3" "54.7" "48.9" "57.2" "" "" "" "" "" "" "" "" "" "" "55.5" "42.8" "30.8" "44.7" "48.3" "35.1" "44.2" "47.1" "38.2" "51.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "7.650" "14" "3" "3" "3" "198" "21.8" "5.88" "8.35" "3" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "" "Neutrophil degranulation; Neddylation" "2" "0" "0.903" "0.891" "0.877" "0.966" "0.922" "0.912" "0.983" "0.919" "0.989" "298.8" "269.9" "266.3" "261.9" "288.6" "275.4" "272.5" "293.6" "274.5" "295.5" "" "" "" "" "" "" "" "" "" "" "298.8" "228.3" "168.4" "191.0" "236.4" "213.8" "210.0" "252.4" "214.2" "265.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "7.650" "4" "1" "1" "1" "390" "42.9" "8.72" "4.75" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.405" "1.461" "1.233" "1.265" "1.467" "1.656" "1.545" "1.473" "1.483" "16.2" "22.7" "23.6" "20.0" "20.5" "23.7" "26.8" "25.0" "23.8" "24.0" "" "" "" "" "" "" "" "" "" "" "16.2" "19.2" "14.9" "14.6" "16.8" "18.4" "20.7" "21.5" "18.6" "21.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "High" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.000" "False" "7.628" "1" "2" "2" "2" "1938" "212.7" "5.88" "5.44" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "786541619406263347" "False" "High" "IsMasterProtein" "O95243" "Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1" "0.000" "False" "7.621" "5" "3" "5" "3" "580" "66.0" "8.82" "15.50" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01429" "8930" "ENSG00000129071" "MBD4" "B4DZN2; D3DNC3; D3DNC4; E9PEE4; hsa:8930; O95243; Q2MD36; Q7Z4T3; Q96F09" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "5" "0" "1.104" "0.809" "1.170" "1.117" "0.961" "1.184" "1.089" "0.931" "1.072" "256.0" "282.7" "207.1" "299.6" "285.9" "246.1" "303.2" "278.8" "238.3" "274.5" "" "" "" "" "" "" "" "" "" "" "256.0" "239.2" "130.9" "218.5" "234.2" "191.1" "233.7" "239.7" "186.0" "246.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "7.613" "9" "3" "4" "2" "336" "39.1" "7.36" "7.37" "3" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4872124519361806264" "False" "High" "IsMasterProtein" "Q9H1P3" "Oxysterol-binding protein-related protein 2 OS=Homo sapiens OX=9606 GN=OSBPL2 PE=1 SV=1" "0.000" "False" "7.612" "5" "3" "3" "3" "480" "55.2" "6.35" "9.00" "3" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01237" "9885" "ENSG00000130703" "OSBPL2" "A8K736; hsa:9885; Q6IBT0; Q9BZB1; Q9H1P3; Q9Y4B8" "" "Synthesis of bile acids and bile salts" "1" "0" "1.046" "0.778" "1.072" "0.957" "0.826" "0.970" "1.001" "0.797" "0.928" "141.8" "148.3" "110.3" "152.0" "135.7" "117.1" "137.6" "142.0" "112.9" "131.5" "" "" "" "" "" "" "" "" "" "" "141.8" "125.5" "69.8" "110.8" "111.2" "90.9" "106.0" "122.1" "88.1" "118.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.000" "False" "7.611" "6" "3" "3" "3" "443" "49.8" "6.48" "7.89" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "0.923" "0.904" "0.917" "0.809" "0.783" "0.834" "0.883" "0.930" "0.815" "256.0" "236.4" "231.5" "234.7" "207.0" "200.5" "213.6" "226.1" "238.1" "208.8" "" "" "" "" "" "" "" "" "" "" "256.0" "200.0" "146.4" "171.1" "169.6" "155.7" "164.7" "194.4" "185.9" "187.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8134142671229236635" "False" "High" "IsMasterProtein" "Q6ZNB6" "NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens OX=9606 GN=NFXL1 PE=1 SV=2" "0.000" "False" "7.600" "2" "1" "1" "1" "911" "101.3" "8.41" "4.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01422" "152518" "ENSG00000170448" "NFXL1" "B1Q2K1; hsa:152518; Q6ZNB6; Q86VG1; Q8WVH1" "" "" "0" "0" "0.936" "2.057" "0.943" "0.866" "2.482" "0.811" "0.583" "2.259" "1.303" "27.9" "26.2" "57.5" "26.4" "24.2" "69.4" "22.7" "16.3" "63.1" "36.4" "" "" "" "" "" "" "" "" "" "" "27.9" "22.1" "36.3" "19.2" "19.8" "53.9" "17.5" "14.0" "49.3" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7160695848866474340" "False" "High" "IsMasterProtein" "Q96JG6" "Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3" "0.000" "False" "7.579" "2" "2" "2" "2" "964" "111.1" "6.20" "7.43" "2" "transport" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf10474, Pf10475" "55610" "ENSG00000004766" "VPS50" "B3KX22; D1MQ00; F5H5U7; hsa:55610; Q75N07; Q8WVK3; Q96JG6; Q9H5C6" "" "" "0" "0" "1.059" "0.975" "1.086" "1.084" "1.062" "1.141" "1.056" "0.989" "1.026" "253.0" "267.9" "246.6" "274.7" "274.4" "268.8" "288.6" "267.1" "250.2" "259.7" "" "" "" "" "" "" "" "" "" "" "253.0" "226.7" "155.9" "200.3" "224.8" "208.8" "222.5" "229.6" "195.3" "233.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "7.578" "4" "2" "2" "2" "429" "48.6" "9.58" "7.38" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "0.932" "0.962" "0.873" "0.893" "1.026" "0.895" "0.897" "1.009" "0.962" "238.8" "222.5" "229.9" "208.5" "213.4" "245.0" "213.8" "214.3" "241.1" "229.6" "" "" "" "" "" "" "" "" "" "" "238.8" "188.2" "145.3" "152.0" "174.8" "190.3" "164.8" "184.2" "188.2" "206.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874502192455067112" "False" "High" "IsMasterProtein" "O00562" "Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4" "0.000" "False" "7.572" "1" "2" "2" "2" "1244" "134.8" "5.95" "6.25" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf02121, Pf02862" "9600" "ENSG00000110697" "PITPNM1" "A6NME4; hsa:9600; O00562; Q6T7X3; Q8TBN3; Q9BZ73" "" "Synthesis of PI" "1" "0" "1.094" "1.196" "1.181" "1.179" "1.124" "1.245" "1.081" "1.204" "1.110" "123.6" "135.2" "147.8" "145.9" "145.7" "138.8" "153.8" "133.6" "148.8" "137.1" "" "" "" "" "" "" "" "" "" "" "123.6" "114.4" "93.4" "106.4" "119.4" "107.8" "118.6" "114.8" "116.1" "123.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4882677413441311349" "False" "High" "IsMasterProtein" "Q8NB14" "Ubiquitin carboxyl-terminal hydrolase 38 OS=Homo sapiens OX=9606 GN=USP38 PE=1 SV=2" "0.000" "False" "7.561" "3" "3" "3" "3" "1042" "116.5" "6.21" "7.80" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf21246" "84640" "ENSG00000170185" "USP38" "B3KX93; hsa:84640; Q3ZCV1; Q8NB14; Q8NDF5; Q96DK6; Q96PZ6; Q9BY55" "" "" "0" "0" "1.012" "0.888" "0.840" "1.036" "0.985" "1.016" "1.070" "0.839" "0.978" "98.7" "99.9" "87.7" "82.9" "102.3" "97.2" "100.3" "105.6" "82.8" "96.5" "" "" "" "" "" "" "" "" "" "" "98.7" "84.5" "55.5" "60.5" "83.8" "75.5" "77.3" "90.8" "64.6" "86.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.000" "False" "7.549" "4" "3" "4" "3" "1298" "141.4" "5.76" "10.83" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation" "8" "0" "1.166" "1.135" "0.928" "1.179" "1.264" "1.303" "1.107" "1.180" "1.147" "88.5" "103.2" "100.5" "82.1" "104.4" "111.9" "115.4" "98.0" "104.4" "101.5" "" "" "" "" "" "" "" "" "" "" "88.5" "87.3" "63.5" "59.9" "85.5" "86.9" "88.9" "84.3" "81.5" "91.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "7.529" "4" "3" "3" "3" "620" "71.6" "5.85" "9.02" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4635662456929640047" "False" "High" "IsMasterProtein" "O15304" "Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2" "0.000" "False" "7.523" "14" "3" "3" "3" "175" "18.7" "7.61" "8.55" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05458" "10572" "ENSG00000184990" "SIVA1" "hsa:10572; O15304; Q96P98; Q9UPD6" "p53 transcriptional gene network" "" "1" "0" "1.041" "0.831" "0.973" "1.037" "0.936" "1.100" "1.054" "0.797" "0.964" "263.3" "274.1" "218.8" "256.2" "273.1" "246.4" "289.5" "277.4" "209.9" "253.9" "" "" "" "" "" "" "" "" "" "" "263.3" "231.9" "138.3" "186.8" "223.7" "191.3" "223.2" "238.5" "163.8" "228.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.000" "False" "7.512" "20" "3" "3" "3" "135" "15.9" "11.33" "9.76" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.969" "1.378" "1.084" "1.029" "1.460" "1.077" "1.304" "1.561" "1.251" "344.4" "333.7" "474.4" "373.3" "354.5" "502.7" "370.9" "449.1" "537.7" "430.6" "" "" "" "" "" "" "" "" "" "" "344.4" "282.4" "300.0" "272.2" "290.4" "390.4" "285.9" "386.1" "419.7" "387.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629092038123866655" "False" "High" "IsMasterProtein" "Q86TP1" "Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2" "0.000" "False" "7.512" "4" "2" "2" "2" "453" "50.2" "5.50" "7.17" "2" "other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01368, Pf02833" "58497" "ENSG00000143363" "PRUNE1" "B2RCH8; B4DFL7; Q5SZF9; Q659E5; Q6P4E0; Q86TP1; Q8N654; Q96JU5; Q9C071; Q9C072; Q9UIV0" "" "" "0" "0" "1.084" "0.983" "1.154" "1.287" "0.997" "1.243" "1.263" "0.851" "1.055" "90.8" "98.4" "89.2" "104.8" "116.9" "90.5" "112.9" "114.7" "77.2" "95.8" "" "" "" "" "" "" "" "" "" "" "90.8" "83.3" "56.4" "76.4" "95.8" "70.3" "87.0" "98.6" "60.3" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "7.511" "12" "3" "8" "3" "196" "21.7" "8.06" "19.80" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "" "HCMV Late Events" "1" "0" "0.961" "0.982" "1.073" "1.069" "0.876" "1.072" "1.004" "0.949" "0.942" "330.1" "317.3" "324.1" "354.3" "352.7" "289.3" "353.8" "331.3" "313.2" "311.0" "" "" "" "" "" "" "" "" "" "" "330.1" "268.4" "204.9" "258.3" "289.0" "224.7" "272.7" "284.8" "244.5" "279.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "7.506" "7" "2" "2" "2" "266" "30.8" "7.47" "6.73" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "7.491" "6" "3" "4" "3" "411" "46.4" "7.65" "11.91" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "0.944" "0.858" "0.880" "0.784" "0.858" "0.845" "0.835" "0.956" "0.760" "203.5" "192.2" "174.6" "179.1" "159.6" "174.6" "171.9" "169.9" "194.6" "154.7" "" "" "" "" "" "" "" "" "" "" "203.5" "162.6" "110.4" "130.6" "130.7" "135.6" "132.5" "146.1" "151.9" "139.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "7.490" "3" "2" "2" "2" "562" "62.6" "8.21" "7.35" "2" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "4" "0" "0.976" "0.934" "0.992" "0.967" "1.018" "1.019" "1.175" "0.928" "1.053" "311.1" "303.6" "290.5" "308.8" "300.8" "316.7" "317.1" "365.4" "288.8" "327.7" "" "" "" "" "" "" "" "" "" "" "311.1" "256.9" "183.7" "225.1" "246.5" "246.0" "244.4" "314.2" "225.4" "294.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.000" "False" "7.476" "4" "2" "2" "2" "420" "49.9" "8.21" "7.02" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "1.015" "0.863" "0.989" "0.855" "0.849" "1.071" "1.049" "0.792" "0.876" "96.5" "98.0" "83.3" "95.5" "82.5" "81.9" "103.4" "101.3" "76.5" "84.6" "" "" "" "" "" "" "" "" "" "" "96.5" "82.9" "52.7" "69.6" "67.6" "63.6" "79.7" "87.1" "59.7" "76.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.000" "False" "7.471" "3" "2" "2" "2" "631" "73.2" "8.15" "6.74" "2" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "0.981" "1.113" "1.115" "1.052" "0.911" "1.036" "0.929" "1.046" "1.143" "70.8" "69.5" "78.9" "79.0" "74.5" "64.5" "73.4" "65.8" "74.1" "81.0" "" "" "" "" "" "" "" "" "" "" "70.8" "58.8" "49.9" "57.6" "61.0" "50.1" "56.6" "56.6" "57.9" "72.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8657126207816692356" "False" "High" "IsMasterProtein" "O43422" "52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2" "0.000" "False" "7.469" "2" "2" "2" "2" "761" "87.6" "5.86" "5.41" "2" "signal transduction;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf05699, Pf14291" "5612" "ENSG00000137492" "THAP12" "A8K728; hsa:5612; O43422; Q17RY9; Q8WTW1; Q9Y3Z4" "" "" "0" "0" "0.918" "0.799" "0.961" "0.950" "1.036" "1.051" "0.950" "0.951" "0.881" "98.0" "90.0" "78.3" "94.2" "93.1" "101.6" "103.0" "93.1" "93.2" "86.3" "" "" "" "" "" "" "" "" "" "" "98.0" "76.1" "49.5" "68.7" "76.3" "78.9" "79.4" "80.0" "72.8" "77.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5327705833801287144" "False" "High" "IsMasterProtein" "Q96EP0" "E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1" "0.000" "False" "7.468" "2" "2" "2" "2" "1072" "119.6" "6.57" "5.57" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01485, Pf09409, Pf16678, Pf18091, Pf18486" "55072" "ENSG00000092098; ENSG00000285152" "RNF31" "A0A962; Q86VI2; Q8TEI0; Q96EP0; Q96GB4; Q96NF1; Q9H5F1; Q9NWD2" "" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8785162228829611300" "False" "High" "IsMasterProtein" "Q38SD2" "Leucine-rich repeat serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=LRRK1 PE=1 SV=3" "0.000" "False" "7.456" "2" "3" "3" "3" "2015" "225.2" "6.68" "7.93" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00069, Pf00560, Pf08477, Pf16095" "79705" "ENSG00000154237" "LRRK1" "Q38SD2; Q6NVH5; Q6NYC0; Q6ZNL9; Q6ZNM9; Q96JN5; Q9H5S3" "" "" "0" "0" "1.205" "1.222" "1.287" "1.304" "1.192" "1.561" "1.192" "1.083" "1.221" "19.5" "23.4" "23.8" "25.0" "25.4" "23.2" "30.4" "23.2" "21.1" "23.8" "" "" "" "" "" "" "" "" "" "" "19.5" "19.8" "15.0" "18.3" "20.8" "18.0" "23.4" "19.9" "16.4" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1728061732538429863" "False" "High" "IsMasterProtein" "Q9UQC2" "GRB2-associated-binding protein 2 OS=Homo sapiens OX=9606 GN=GAB2 PE=1 SV=1" "0.000" "False" "7.456" "3" "2" "2" "2" "676" "74.4" "8.31" "6.18" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169" "9846" "ENSG00000033327" "GAB2" "A2RRM2; A6NEW9; A7MD36; hsa:9846; O60317; Q9UQC2" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Imatinib and chronic myeloid leukemia; BDNF-TrkB signaling; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; IL-2 signaling pathway; GDNF signaling; Interferon type I signaling pathways; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; Role of LAT2/NTAL/LAB on calcium mobilization; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; PI3K Cascade; Signaling by SCF-KIT; Signaling by CSF3 (G-CSF); Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; STAT5 Activation" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.000" "False" "7.454" "11" "2" "2" "2" "205" "23.3" "5.49" "6.87" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.014" "0.811" "1.038" "1.009" "0.931" "1.103" "1.010" "0.992" "0.927" "69.9" "70.9" "56.7" "72.6" "70.5" "65.1" "77.1" "70.6" "69.4" "64.8" "" "" "" "" "" "" "" "" "" "" "69.9" "60.0" "35.9" "52.9" "57.8" "50.6" "59.5" "60.7" "54.2" "58.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-796628633734857382" "False" "High" "IsMasterProtein" "Q13439" "Golgin subfamily A member 4 OS=Homo sapiens OX=9606 GN=GOLGA4 PE=1 SV=1" "0.000" "False" "7.437" "1" "2" "2" "2" "2230" "261.0" "5.39" "6.09" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01465" "2803" "ENSG00000144674" "GOLGA4" "F8W8Q7; hsa:2803; Q13270; Q13439; Q13654; Q14436; Q59EW8" "" "Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "2" "0" "1.023" "0.924" "1.223" "0.994" "0.799" "1.184" "1.037" "0.838" "0.970" "94.5" "96.6" "87.3" "115.6" "93.9" "75.4" "111.8" "98.0" "79.1" "91.6" "" "" "" "" "" "" "" "" "" "" "94.5" "81.7" "55.2" "84.3" "77.0" "58.6" "86.2" "84.3" "61.8" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782188447227820628" "False" "High" "IsMasterProtein" "Q17RB0" "Retrotransposon Gag-like protein 8B OS=Homo sapiens OX=9606 GN=RTL8B PE=1 SV=1" "0.000" "False" "7.434" "13" "1" "2" "1" "113" "13.2" "5.27" "7.94" "1" "" "" "" "Pf16297" "441518" "ENSG00000212747" "RTL8B" "hsa:441518; Q17RB0" "" "" "0" "0" "1.112" "0.783" "0.946" "1.064" "0.822" "1.234" "1.087" "0.935" "1.036" "65.7" "73.1" "51.5" "62.2" "69.9" "54.0" "81.1" "71.4" "61.4" "68.1" "" "" "" "" "" "" "" "" "" "" "65.7" "61.8" "32.6" "45.3" "57.3" "42.0" "62.5" "61.4" "47.9" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.000" "False" "7.432" "11" "2" "4" "1" "202" "22.4" "4.56" "10.61" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "0" "0.869" "0.836" "0.745" "1.119" "0.592" "0.615" "0.675" "1.135" "1.004" "21.7" "18.8" "18.1" "16.2" "24.3" "12.8" "13.3" "14.6" "24.6" "21.8" "" "" "" "" "" "" "" "" "" "" "21.7" "15.9" "11.5" "11.8" "19.9" "10.0" "10.3" "12.6" "19.2" "19.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "7.429" "13" "2" "3" "2" "178" "20.4" "5.03" "8.98" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.156" "1.069" "1.396" "1.209" "1.289" "1.051" "1.197" "1.179" "1.000" "64.7" "74.8" "69.1" "90.2" "78.2" "83.3" "68.0" "77.4" "76.3" "64.7" "" "" "" "" "" "" "" "" "" "" "64.7" "63.2" "43.7" "65.8" "64.1" "64.7" "52.4" "66.5" "59.5" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4361926129006051556" "False" "High" "IsMasterProtein" "Q9BSH4" "Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1" "0.000" "False" "7.428" "7" "2" "2" "2" "297" "32.5" "8.13" "7.38" "2" "cell organization and biogenesis;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf01709, Pf20772" "51204" "ENSG00000136463" "TACO1" "B2RD21; hsa:51204; Q8N3N6; Q9BSH4; Q9UI60" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "4" "0" "0.988" "0.909" "1.125" "0.813" "0.784" "0.867" "0.867" "0.829" "0.950" "237.7" "234.7" "216.1" "267.4" "193.3" "186.4" "206.1" "206.2" "197.1" "225.8" "" "" "" "" "" "" "" "" "" "" "237.7" "198.6" "136.6" "195.0" "158.4" "144.8" "158.9" "177.2" "153.9" "203.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1043887443334271491" "False" "High" "IsMasterProtein" "Q9H714" "Protein associated with UVRAG as autophagy enhancer OS=Homo sapiens OX=9606 GN=RUBCNL PE=1 SV=3" "0.000" "False" "7.423" "4" "3" "3" "3" "662" "73.4" "6.04" "8.01" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13901, Pf21054" "80183" "ENSG00000102445" "RUBCNL" "A8KAG9; A8XR19; B3KS87; hsa:80183; Q5W051; Q5W053; Q6PJ74; Q6PK94; Q86XH7; Q8N5J6; Q9H714" "" "" "0" "0" "0.884" "0.647" "0.786" "0.854" "0.733" "1.013" "0.896" "0.660" "1.023" "119.8" "105.9" "77.5" "94.2" "102.3" "87.8" "121.4" "107.4" "79.0" "122.6" "" "" "" "" "" "" "" "" "" "" "119.8" "89.6" "49.0" "68.7" "83.9" "68.2" "93.6" "92.3" "61.7" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "7.422" "16" "3" "4" "3" "148" "16.4" "9.95" "12.81" "3" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "1.010" "1.120" "0.988" "0.873" "0.863" "0.950" "0.806" "0.934" "0.987" "270.1" "272.6" "302.6" "266.7" "235.9" "233.0" "256.6" "217.7" "252.3" "266.7" "" "" "" "" "" "" "" "" "" "" "270.1" "230.7" "191.3" "194.5" "193.3" "180.9" "197.8" "187.2" "196.9" "239.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "7.401" "13" "3" "4" "3" "227" "26.5" "8.41" "10.75" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "2" "0" "1.119" "0.906" "1.120" "1.087" "1.062" "1.083" "0.882" "0.986" "0.917" "78.6" "88.0" "71.2" "88.0" "85.4" "83.5" "85.1" "69.3" "77.5" "72.1" "" "" "" "" "" "" "" "" "" "" "78.6" "74.4" "45.0" "64.2" "70.0" "64.8" "65.6" "59.6" "60.5" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.000" "False" "7.394" "7" "2" "2" "2" "454" "49.4" "6.46" "6.22" "2" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904410846819458044" "False" "High" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "0.000" "False" "7.392" "2" "1" "2" "1" "817" "90.3" "7.03" "6.60" "1" "cell adhesion;cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "11" "0" "1.077" "0.867" "1.185" "0.936" "0.973" "1.051" "1.033" "0.951" "0.867" "48.2" "51.9" "41.8" "57.1" "45.1" "46.9" "50.6" "49.7" "45.8" "41.8" "" "" "" "" "" "" "" "" "" "" "48.2" "43.9" "26.4" "41.6" "36.9" "36.4" "39.0" "42.8" "35.8" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.000" "False" "7.386" "11" "2" "4" "2" "188" "21.2" "5.31" "12.89" "2" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "1.064" "0.870" "1.132" "1.095" "0.914" "1.177" "1.086" "0.893" "1.059" "131.5" "139.9" "114.5" "148.9" "144.1" "120.2" "154.9" "142.9" "117.5" "139.2" "" "" "" "" "" "" "" "" "" "" "131.5" "118.3" "72.4" "108.5" "118.0" "93.3" "119.4" "122.9" "91.7" "125.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "7.364" "19" "2" "2" "2" "103" "12.0" "5.91" "6.36" "2" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "7.361" "3" "3" "3" "3" "942" "106.1" "5.59" "7.55" "3" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "Aryl hydrocarbon receptor pathway" "" "1" "0" "1.035" "1.141" "0.909" "1.032" "1.116" "0.976" "1.009" "0.998" "1.107" "36.2" "37.5" "41.3" "32.9" "37.4" "40.4" "35.3" "36.5" "36.1" "40.1" "" "" "" "" "" "" "" "" "" "" "36.2" "31.7" "26.1" "24.0" "30.6" "31.4" "27.2" "31.4" "28.2" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274015145252682130" "False" "High" "IsMasterProtein" "Q9UH62" "Armadillo repeat-containing X-linked protein 3 OS=Homo sapiens OX=9606 GN=ARMCX3 PE=1 SV=1" "0.000" "False" "7.348" "5" "2" "2" "2" "379" "42.5" "8.37" "6.53" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "" "Pf04826" "51566" "ENSG00000102401" "ARMCX3" "hsa:51566; Q53HC6; Q7LCF5; Q9NPE4; Q9UH62" "" "RAC2 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7880695163940437874" "False" "High" "IsMasterProtein" "Q9Y580" "RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1" "0.000" "False" "7.341" "7" "2" "2" "2" "266" "30.5" "9.57" "5.98" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "10179" "ENSG00000076053" "RBM7" "B2R6K8; hsa:10179; Q9NUT4; Q9Y580" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "7.325" "5" "2" "2" "2" "389" "43.2" "5.36" "6.50" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "Initiation of Nuclear Envelope (NE) Reformation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.000" "False" "7.320" "4" "2" "3" "2" "510" "57.5" "5.67" "7.05" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "TAR syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230098152541367258" "False" "High" "IsMasterProtein" "Q14934" "Nuclear factor of activated T-cells, cytoplasmic 4 OS=Homo sapiens OX=9606 GN=NFATC4 PE=1 SV=2" "0.000" "False" "7.307" "3" "3" "4" "1" "902" "95.4" "5.38" "8.16" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4776" "ENSG00000100968; ENSG00000285485" "NFATC4" "B4DDG5; B4DY55; B5B2U7; B5B2U8; B5B2U9; B5B2V0; B5B2V1; B5B2V2; B5B2V3; B5B2V4; B5B2V5; B5B2V7; B5B2V8; B5B2V9; B5B2W0; B5B2W1; B5B2W2; B5B2W3; B5B2W4; B5B2W5; B5B2W6; B5B2W7; B5B2W8; B5B2W9; B5B2X0; hsa:4776; Q14934; Q7Z598; Q96H68" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Heart development; Brain-derived neurotrophic factor (BDNF) signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; IL-18 signaling pathway" "" "9" "0" "1.014" "0.796" "1.240" "1.017" "0.943" "0.975" "0.880" "0.950" "0.993" "47.5" "48.2" "37.9" "59.0" "48.4" "44.8" "46.3" "41.8" "45.2" "47.2" "" "" "" "" "" "" "" "" "" "" "47.5" "40.8" "23.9" "43.0" "39.6" "34.8" "35.7" "36.0" "35.3" "42.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7257835409588343997" "False" "High" "IsMasterProtein" "Q96IZ6" "tRNA N(3)-methylcytidine methyltransferase METTL2A OS=Homo sapiens OX=9606 GN=METTL2A PE=1 SV=5" "0.000" "False" "7.305" "7" "2" "2" "1" "378" "43.5" "6.01" "7.70" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "339175" "ENSG00000087995" "METTL2A" "A6NNC4; hsa:339175; Q96IZ6; Q9H9G9; Q9NUI8; Q9P0B5" "" "" "0" "0" "1.062" "0.855" "1.082" "1.070" "0.949" "1.125" "1.254" "0.899" "0.968" "125.1" "132.9" "107.0" "135.4" "133.9" "118.8" "140.8" "157.0" "112.6" "121.2" "" "" "" "" "" "" "" "" "" "" "125.1" "112.4" "67.6" "98.8" "109.7" "92.2" "108.5" "135.0" "87.9" "108.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "7.303" "22" "1" "1" "1" "91" "9.6" "4.87" "5.35" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "317033728722267888" "False" "High" "IsMasterProtein" "P34913" "Bifunctional epoxide hydrolase 2 OS=Homo sapiens OX=9606 GN=EPHX2 PE=1 SV=2" "0.000" "False" "7.301" "5" "3" "3" "3" "555" "62.6" "6.28" "8.18" "3" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00561, Pf00702" "2053" "ENSG00000120915" "EPHX2" "B2Z3B1; B3KTU8; B3KUA0; G3V134; hsa:2053; J3KPH7; P34913; Q16764; Q9HBJ1; Q9HBJ2" "Eicosanoid metabolism via cytochrome P450 monooxygenases pathway; Familial hyperlipidemia type 2; ALA oxylipin metabolism; Linoleic acid oxylipin metabolism; Docosahexaenoic acid oxylipin metabolism; Arachidonic acid (AA, ARA) oxylipin metabolism; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Biosynthesis of maresins" "12" "0" "0.867" "0.896" "1.015" "0.946" "0.763" "0.755" "0.832" "0.947" "0.768" "46.7" "40.4" "41.8" "47.4" "44.2" "35.6" "35.3" "38.8" "44.2" "35.8" "" "" "" "" "" "" "" "" "" "" "46.7" "34.2" "26.4" "34.6" "36.2" "27.6" "27.2" "33.4" "34.5" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331162755834209068" "False" "High" "IsMasterProtein" "Q8IWR0" "Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1" "0.000" "False" "7.294" "2" "2" "2" "2" "971" "110.5" "7.30" "6.31" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642" "29066" "ENSG00000122299" "ZC3H7A" "D3DUG5; hsa:29066; Q8IWR0; Q9NPE9" "" "" "0" "0" "1.087" "0.932" "0.985" "0.998" "0.957" "0.942" "0.896" "1.000" "0.817" "55.7" "60.5" "51.9" "54.8" "55.5" "53.3" "52.5" "49.9" "55.7" "45.5" "" "" "" "" "" "" "" "" "" "" "55.7" "51.2" "32.8" "40.0" "45.5" "41.4" "40.4" "42.9" "43.4" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-375580382225270930" "False" "High" "IsMasterProtein" "Q96LI5" "CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2" "0.000" "False" "7.290" "3" "1" "1" "1" "555" "63.0" "6.74" "4.89" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03372, Pf13855" "246175" "ENSG00000138767" "CNOT6L" "hsa:246175; Q96LI5; Q9UF92" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "7.282" "5" "3" "3" "3" "514" "57.2" "9.17" "9.31" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.105" "1.399" "1.142" "1.071" "1.378" "1.034" "1.235" "1.327" "1.030" "126.3" "139.5" "176.6" "144.2" "135.3" "174.1" "130.6" "155.9" "167.6" "130.0" "" "" "" "" "" "" "" "" "" "" "126.3" "118.1" "111.7" "105.1" "110.8" "135.2" "100.6" "134.1" "130.8" "116.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "7.280" "14" "3" "3" "3" "209" "23.6" "4.96" "5.63" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "5" "0" "1.011" "1.084" "0.937" "1.046" "1.229" "1.040" "1.243" "1.097" "0.980" "104.5" "105.7" "113.3" "97.9" "109.3" "128.5" "108.7" "129.9" "114.6" "102.4" "" "" "" "" "" "" "" "" "" "" "104.5" "89.4" "71.7" "71.4" "89.6" "99.8" "83.8" "111.7" "89.5" "92.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.000" "False" "7.279" "12" "2" "2" "2" "229" "25.6" "5.92" "6.41" "2" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "PAFAH1B1 copy number variation" "Neutrophil degranulation; COPI-independent Golgi-to-ER retrograde traffic" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.000" "False" "7.275" "2" "2" "2" "2" "1084" "119.0" "6.96" "6.17" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "20" "0" "1.152" "1.149" "1.035" "1.069" "1.095" "1.040" "1.090" "1.324" "1.012" "119.1" "137.2" "136.9" "123.3" "127.4" "130.4" "123.9" "129.8" "157.7" "120.6" "" "" "" "" "" "" "" "" "" "" "119.1" "116.1" "86.6" "89.9" "104.3" "101.3" "95.5" "111.6" "123.1" "108.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "7.274" "7" "2" "2" "2" "328" "35.2" "8.48" "7.16" "2" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "" "RHOBTB2 GTPase cycle" "1" "0" "1.339" "1.072" "1.580" "1.359" "1.136" "1.362" "1.354" "1.303" "1.271" "24.1" "32.3" "25.8" "38.1" "32.7" "27.4" "32.8" "32.6" "31.4" "30.6" "" "" "" "" "" "" "" "" "" "" "24.1" "27.3" "16.3" "27.8" "26.8" "21.2" "25.3" "28.0" "24.5" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8883719811085477974" "False" "High" "IsMasterProtein" "P19419" "ETS domain-containing protein Elk-1 OS=Homo sapiens OX=9606 GN=ELK1 PE=1 SV=2" "0.000" "False" "7.274" "4" "2" "2" "2" "428" "44.9" "6.89" "5.71" "2" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2002" "ENSG00000126767" "ELK1" "B2R7H4; hsa:2002; O75606; O95058; P19419; Q969X8; Q9UJM4" "IL-5 signaling pathway; Thyroxine (thyroid hormone) production; SRF and miRs in smooth muscle differentiation and proliferation; Leptin signaling pathway; Prolactin signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Photodynamic therapy-induced AP-1 survival signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; p38 MAPK signaling pathway; Endometrial cancer; MAPK cascade; Ras signaling; EGF/EGFR signaling pathway; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Insulin signaling; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; ID signaling pathway; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "NGF-stimulated transcription; HCMV Early Events; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; ERK/MAPK targets" "45" "0" "0.979" "0.892" "1.077" "1.105" "0.893" "0.985" "0.952" "0.821" "0.960" "147.9" "144.8" "131.9" "159.3" "163.5" "132.1" "145.7" "140.8" "121.5" "142.1" "" "" "" "" "" "" "" "" "" "" "147.9" "122.5" "83.4" "116.2" "134.0" "102.6" "112.3" "121.1" "94.8" "127.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.000" "False" "7.272" "9" "2" "2" "2" "271" "30.0" "5.47" "6.88" "2" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "13" "0" "1.079" "0.712" "0.991" "1.075" "0.774" "0.874" "0.784" "0.970" "1.059" "27.3" "29.5" "19.4" "27.1" "29.4" "21.1" "23.9" "21.4" "26.5" "28.9" "" "" "" "" "" "" "" "" "" "" "27.3" "24.9" "12.3" "19.7" "24.1" "16.4" "18.4" "18.4" "20.7" "26.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "7.260" "4" "2" "2" "2" "492" "54.1" "6.38" "7.19" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "HCMV Early Events; COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "0.925" "1.015" "1.088" "1.048" "0.883" "1.045" "1.003" "0.865" "0.943" "172.0" "159.0" "174.5" "187.1" "180.3" "151.9" "179.7" "172.5" "148.8" "162.1" "" "" "" "" "" "" "" "" "" "" "172.0" "134.5" "110.4" "136.4" "147.7" "118.0" "138.5" "148.3" "116.1" "145.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659552786150411994" "False" "High" "IsMasterProtein" "O75127" "Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2" "0.000" "False" "7.251" "3" "2" "2" "2" "700" "78.8" "8.59" "6.77" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf01535" "26024" "ENSG00000106246" "PTCD1" "hsa:26024; O75127; Q3ZB78; Q66K60; Q9UDV2" "" "" "0" "0" "1.098" "1.010" "1.138" "1.226" "0.834" "1.157" "1.244" "0.824" "0.955" "48.6" "53.4" "49.1" "55.4" "59.6" "40.6" "56.3" "60.5" "40.1" "46.5" "" "" "" "" "" "" "" "" "" "" "48.6" "45.2" "31.1" "40.4" "48.9" "31.5" "43.4" "52.0" "31.3" "41.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "High" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.000" "False" "7.241" "3" "2" "3" "2" "643" "73.3" "7.40" "8.26" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Intracellular trafficking proteins involved in CMT neuropathy" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane" "5" "0" "1.058" "1.086" "1.143" "1.072" "1.257" "0.876" "1.162" "0.983" "1.212" "52.3" "55.3" "56.8" "59.7" "56.0" "65.7" "45.8" "60.7" "51.4" "63.4" "" "" "" "" "" "" "" "" "" "" "52.3" "46.8" "35.9" "43.6" "45.9" "51.0" "35.3" "52.2" "40.1" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "7.239" "3" "3" "3" "3" "920" "106.1" "9.98" "9.46" "3" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.141" "1.854" "1.227" "1.174" "1.767" "1.377" "1.240" "1.759" "1.456" "210.8" "240.6" "390.9" "258.6" "247.5" "372.6" "290.3" "261.5" "370.9" "307.1" "" "" "" "" "" "" "" "" "" "" "210.8" "203.5" "247.1" "188.6" "202.8" "289.3" "223.8" "224.8" "289.5" "276.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "7.237" "7" "2" "2" "2" "299" "33.6" "8.03" "7.50" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "0.987" "0.936" "1.215" "1.083" "0.912" "1.066" "0.935" "1.013" "0.945" "55.3" "54.5" "51.7" "67.1" "59.9" "50.4" "58.9" "51.7" "56.0" "52.2" "" "" "" "" "" "" "" "" "" "" "55.3" "46.2" "32.7" "49.0" "49.1" "39.2" "45.4" "44.5" "43.7" "47.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4052352701498406510" "False" "High" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "0.000" "False" "7.216" "4" "3" "3" "3" "622" "67.8" "8.97" "7.63" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "" "HATs acetylate histones" "1" "0" "1.021" "0.870" "1.036" "1.018" "0.911" "0.964" "0.897" "0.918" "0.977" "79.9" "81.6" "69.5" "82.8" "81.3" "72.8" "77.0" "71.7" "73.3" "78.1" "" "" "" "" "" "" "" "" "" "" "79.9" "69.0" "43.9" "60.3" "66.6" "56.5" "59.3" "61.6" "57.2" "70.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "7.210" "21" "3" "3" "3" "139" "15.3" "9.99" "8.86" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.043" "1.121" "0.966" "1.018" "0.889" "0.842" "0.726" "1.007" "1.181" "159.9" "166.8" "179.3" "154.5" "162.7" "142.1" "134.6" "116.1" "161.0" "188.9" "" "" "" "" "" "" "" "" "" "" "159.9" "141.1" "113.4" "112.7" "133.3" "110.3" "103.8" "99.8" "125.7" "169.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3729688095668830132" "False" "High" "IsMasterProtein" "O75419" "Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1" "0.000" "False" "7.210" "4" "2" "2" "2" "566" "65.5" "5.53" "6.37" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02724" "8318" "ENSG00000093009" "CDC45" "B4DDB4; B4DDU3; E9PDH7; hsa:8318; O60856; O75419; Q20WK8; Q6UW54; Q9UP68" "Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription" "9" "0" "1.016" "0.868" "1.104" "1.082" "0.936" "1.128" "1.064" "0.874" "0.991" "183.0" "186.0" "158.8" "202.0" "198.0" "171.3" "206.5" "194.8" "159.9" "181.3" "" "" "" "" "" "" "" "" "" "" "183.0" "157.3" "100.4" "147.3" "162.2" "133.1" "159.2" "167.5" "124.8" "163.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "7.202" "7" "2" "2" "1" "378" "43.4" "5.86" "7.76" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "1" "1.243" "0.862" "1.183" "1.149" "0.875" "1.147" "1.058" "1.031" "1.039" "121.6" "151.1" "104.8" "143.8" "139.6" "106.3" "139.5" "128.6" "125.4" "126.3" "" "" "" "" "" "" "" "" "" "" "121.6" "127.8" "66.3" "104.8" "114.4" "82.6" "107.5" "110.6" "97.9" "113.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219070174713908542" "False" "High" "IsMasterProtein" "P04049" "RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1" "0.000" "False" "7.198" "4" "3" "3" "1" "648" "73.0" "9.20" "6.33" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf02196" "5894" "ENSG00000132155" "RAF1" "B0LPH8; B2R5N3; hsa:5894; P04049; Q15278; Q9UC20" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 7q11.23 distal copy number variation; 15q25 copy number variation; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Stimuli-sensing channels; Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway" "104" "0" "0.911" "0.730" "0.937" "0.994" "0.845" "0.886" "1.030" "0.756" "1.036" "115.7" "105.4" "84.4" "108.3" "114.9" "97.8" "102.4" "119.1" "87.5" "119.8" "" "" "" "" "" "" "" "" "" "" "115.7" "89.1" "53.3" "79.0" "94.1" "75.9" "79.0" "102.4" "68.3" "107.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.000" "False" "7.192" "1" "2" "2" "2" "2517" "257.9" "8.10" "5.22" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-989694424414112882" "False" "High" "IsMasterProtein" "Q6P2P2" "Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1" "0.000" "False" "7.188" "3" "3" "3" "3" "845" "94.4" "5.25" "5.43" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf06325" "90826" "ENSG00000164169" "PRMT9" "A8KA39; B3KU92; hsa:90826; Q6P2P2; Q6ZR58; Q8N383; Q9BT55; Q9NT98" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "7.187" "4" "2" "2" "2" "465" "52.8" "6.70" "7.43" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "1.131" "0.971" "1.109" "1.078" "1.046" "1.160" "1.081" "1.025" "0.903" "88.5" "100.1" "85.9" "98.2" "95.5" "92.6" "102.6" "95.7" "90.8" "80.0" "" "" "" "" "" "" "" "" "" "" "88.5" "84.7" "54.3" "71.6" "78.2" "71.9" "79.1" "82.3" "70.8" "71.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.000" "False" "7.184" "4" "3" "3" "3" "861" "97.1" "5.64" "8.02" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.091" "1.016" "1.100" "1.190" "0.868" "1.312" "1.121" "0.934" "1.047" "63.0" "68.8" "64.0" "69.4" "75.0" "54.7" "82.7" "70.6" "58.9" "66.0" "" "" "" "" "" "" "" "" "" "" "63.0" "58.2" "40.5" "50.6" "61.4" "42.5" "63.8" "60.7" "45.9" "59.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-334461821702611292" "False" "High" "IsMasterProtein" "Q6DCA0" "AMMECR1-like protein OS=Homo sapiens OX=9606 GN=AMMECR1L PE=1 SV=1" "0.000" "False" "7.182" "10" "3" "3" "3" "310" "34.5" "8.98" "7.63" "3" "" "nucleus" "" "Pf01871" "83607" "ENSG00000144233" "AMMECR1L" "B4E276; hsa:83607; Q6DCA0" "" "" "0" "0" "1.411" "1.262" "2.139" "1.455" "1.280" "1.287" "1.259" "1.231" "1.475" "16.2" "22.8" "20.4" "34.6" "23.5" "20.7" "20.8" "20.4" "19.9" "23.9" "" "" "" "" "" "" "" "" "" "" "16.2" "19.3" "12.9" "25.2" "19.3" "16.1" "16.1" "17.5" "15.6" "21.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "7.180" "3" "2" "3" "2" "547" "59.0" "6.89" "9.75" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "10" "0" "1.098" "1.062" "1.022" "1.051" "1.255" "1.370" "1.123" "1.086" "1.129" "187.0" "205.3" "198.6" "191.1" "196.6" "234.7" "256.3" "210.0" "203.1" "211.1" "" "" "" "" "" "" "" "" "" "" "187.0" "173.7" "125.6" "139.3" "161.0" "182.2" "197.5" "180.6" "158.5" "189.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.000" "False" "7.174" "11" "3" "5" "3" "204" "24.1" "11.62" "14.69" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.980" "1.312" "1.002" "1.146" "1.482" "1.180" "1.357" "1.383" "1.133" "274.1" "268.6" "359.7" "274.7" "314.1" "406.1" "323.4" "372.0" "379.0" "310.6" "" "" "" "" "" "" "" "" "" "" "274.1" "227.2" "227.4" "200.3" "257.3" "315.4" "249.3" "319.9" "295.8" "279.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933841314574218963" "False" "High" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "0.000" "False" "7.161" "6" "2" "2" "2" "342" "39.8" "8.15" "6.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.878" "0.826" "1.001" "0.896" "0.913" "0.924" "0.916" "0.849" "0.870" "146.5" "128.6" "121.0" "146.7" "131.3" "133.7" "135.3" "134.2" "124.3" "127.4" "" "" "" "" "" "" "" "" "" "" "146.5" "108.8" "76.5" "107.0" "107.6" "103.8" "104.3" "115.4" "97.0" "114.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "7.157" "4" "3" "3" "3" "628" "68.7" "5.69" "7.49" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.000" "False" "7.157" "1" "2" "2" "2" "3065" "336.0" "6.90" "6.60" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Pathways affected in adenoid cystic carcinoma" "Transcriptional Regulation by E2F6" "2" "0" "1.293" "0.622" "1.371" "1.396" "1.520" "1.128" "1.010" "1.381" "1.095" "12.4" "16.1" "7.7" "17.0" "17.3" "18.9" "14.0" "12.5" "17.1" "13.6" "" "" "" "" "" "" "" "" "" "" "12.4" "13.6" "4.9" "12.4" "14.2" "14.6" "10.8" "10.8" "13.4" "12.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2313523377555804982" "False" "High" "IsMasterProtein" "P49754" "Vacuolar protein sorting-associated protein 41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3" "0.000" "False" "7.151" "3" "3" "3" "3" "854" "98.5" "5.85" "7.83" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00637" "27072" "ENSG00000006715" "VPS41" "E9PF36; hsa:27072; P49754; Q86TP8; Q99851; Q99852" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "1.052" "0.939" "1.124" "1.158" "1.010" "1.155" "1.131" "0.998" "1.079" "218.3" "229.7" "204.9" "245.3" "252.8" "220.4" "252.2" "247.0" "217.8" "235.6" "" "" "" "" "" "" "" "" "" "" "218.3" "194.3" "129.5" "178.8" "207.1" "171.2" "194.4" "212.4" "170.0" "211.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5976124044734252657" "False" "High" "IsMasterProtein" "Q8WYA0" "Intraflagellar transport protein 81 homolog OS=Homo sapiens OX=9606 GN=IFT81 PE=1 SV=1" "0.000" "False" "7.149" "3" "2" "2" "2" "676" "79.7" "8.82" "6.31" "2" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf18383" "28981" "ENSG00000122970" "IFT81" "Q2YDY1; Q8NB51; Q8WYA0; Q9BSV2; Q9UNY8" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "7" "0" "1.002" "0.909" "1.041" "1.048" "0.932" "1.023" "1.049" "0.943" "1.078" "133.8" "134.1" "121.6" "139.4" "140.2" "124.7" "136.9" "140.4" "126.2" "144.3" "" "" "" "" "" "" "" "" "" "" "133.8" "113.5" "76.9" "101.6" "114.9" "96.8" "105.5" "120.7" "98.5" "129.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.000" "False" "7.140" "3" "3" "3" "3" "832" "94.3" "6.70" "8.44" "3" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.708" "0.672" "0.883" "0.763" "0.568" "0.704" "0.671" "0.846" "0.584" "25.6" "18.1" "17.2" "22.6" "19.5" "14.5" "18.0" "17.2" "21.6" "14.9" "" "" "" "" "" "" "" "" "" "" "25.6" "15.3" "10.9" "16.4" "16.0" "11.3" "13.9" "14.7" "16.9" "13.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "7.131" "7" "2" "2" "2" "362" "38.5" "4.98" "6.30" "2" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "" "Regulation of the apoptosome activity" "2" "0" "0.858" "0.903" "0.961" "0.976" "0.924" "1.089" "0.953" "0.863" "0.847" "84.5" "72.5" "76.3" "81.2" "82.4" "78.0" "92.0" "80.5" "72.9" "71.5" "" "" "" "" "" "" "" "" "" "" "84.5" "61.3" "48.2" "59.2" "67.5" "60.6" "70.9" "69.2" "56.9" "64.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6761178778762072522" "False" "High" "IsMasterProtein" "P29460" "Interleukin-12 subunit beta OS=Homo sapiens OX=9606 GN=IL12B PE=1 SV=1" "0.000" "False" "7.119" "6" "1" "1" "1" "328" "37.1" "5.74" "4.85" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf10420" "3593" "ENSG00000113302" "IL12B" "hsa:3593; P29460" "Allograft rejection; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Lung fibrosis; Development and heterogeneity of the ILC family; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; Resistin as a regulator of inflammation; Selective expression of chemokine receptors during T-cell polarization; Measles virus infection; IL-18 signaling pathway; Neuroinflammation and glutamatergic signaling; Overview of proinflammatory and profibrotic mediators; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; Toll-like receptor signaling pathway" "Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interleukin-12 signaling; Interleukin-23 signaling" "20" "0" "0.874" "0.678" "1.008" "1.128" "1.310" "1.370" "1.195" "0.982" "1.188" "18.7" "16.4" "12.7" "18.9" "21.1" "24.5" "25.6" "22.4" "18.4" "22.2" "" "" "" "" "" "" "" "" "" "" "18.7" "13.8" "8.0" "13.7" "17.3" "19.0" "19.8" "19.2" "14.3" "20.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "7.117" "4" "2" "2" "1" "473" "51.2" "8.03" "7.16" "2" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3580192836813559225" "False" "High" "IsMasterProtein" "O95425" "Supervillin OS=Homo sapiens OX=9606 GN=SVIL PE=1 SV=2" "0.000" "False" "7.108" "1" "2" "2" "2" "2214" "247.6" "6.98" "5.92" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626, Pf02209" "6840" "ENSG00000197321" "SVIL" "D3DRW9; hsa:6840; M1J557; O60611; O60612; O95425; Q5VZK5; Q5VZK6; Q9H1R7" "" "" "0" "0" "0.935" "1.171" "1.228" "1.028" "1.186" "1.067" "1.060" "1.040" "0.871" "30.6" "28.6" "35.8" "37.5" "31.4" "36.2" "32.6" "32.4" "31.8" "26.6" "" "" "" "" "" "" "" "" "" "" "30.6" "24.2" "22.6" "27.4" "25.7" "28.1" "25.1" "27.8" "24.8" "23.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1000021269069197599" "False" "High" "IsMasterProtein" "Q9Y5V3" "Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3" "0.000" "False" "7.102" "3" "2" "2" "1" "778" "86.1" "5.83" "7.66" "2" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01454" "9500" "ENSG00000179222" "MAGED1" "hsa:9500; Q5VSH6; Q8IZ84; Q8WY92; Q9H352; Q9HBT4; Q9UF36; Q9Y5V3" "5q35 copy number variation" "NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178980302497891247" "False" "High" "IsMasterProtein" "P29597" "Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens OX=9606 GN=TYK2 PE=1 SV=3" "0.000" "False" "7.101" "3" "3" "3" "3" "1187" "133.6" "7.15" "8.68" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "7297" "ENSG00000105397" "TYK2" "hsa:7297; P29597; Q6QB10; Q96CH0" "Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Th17 cell differentiation pathway; IL-26 signaling pathways; Interferon type I signaling pathways" "Interleukin-4 and Interleukin-13 signaling; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Evasion by RSV of host interferon responses; Other interleukin signaling" "36" "0" "0.856" "0.612" "0.997" "0.906" "0.741" "0.967" "1.007" "0.660" "0.882" "120.1" "102.8" "73.5" "119.6" "108.7" "89.0" "116.1" "120.9" "79.3" "105.9" "" "" "" "" "" "" "" "" "" "" "120.1" "87.0" "46.5" "87.2" "89.1" "69.1" "89.5" "103.9" "61.9" "95.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "High" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.000" "False" "7.100" "21" "2" "2" "2" "81" "9.0" "5.90" "6.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "DNA repair pathways, full network" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "4" "0" "0.921" "1.236" "0.957" "0.993" "1.364" "1.177" "0.945" "1.213" "0.954" "275.7" "253.8" "340.8" "263.9" "273.8" "376.1" "324.6" "260.5" "334.3" "263.0" "" "" "" "" "" "" "" "" "" "" "275.7" "214.8" "215.5" "192.5" "224.3" "292.0" "250.2" "224.0" "261.0" "236.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893746772392115503" "False" "High" "IsMasterProtein" "Q6P1L5" "Protein FAM117B OS=Homo sapiens OX=9606 GN=FAM117B PE=1 SV=2" "0.000" "False" "7.097" "5" "2" "2" "2" "589" "61.9" "9.82" "8.45" "2" "" "" "" "Pf15388" "150864" "ENSG00000138439" "FAM117B" "hsa:150864; Q53QZ5; Q585T9; Q6P1L5; Q8N8W1; Q96Q34" "" "" "0" "0" "0.861" "0.680" "1.126" "1.061" "0.814" "1.227" "1.045" "0.830" "0.956" "62.2" "53.5" "42.3" "70.0" "66.0" "50.6" "76.3" "65.0" "51.6" "59.5" "" "" "" "" "" "" "" "" "" "" "62.2" "45.3" "26.7" "51.1" "54.1" "39.3" "58.8" "55.9" "40.3" "53.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6455184460611174421" "False" "High" "IsMasterProtein" "Q96FN4" "Copine-2 OS=Homo sapiens OX=9606 GN=CPNE2 PE=1 SV=3" "0.000" "False" "7.091" "3" "2" "3" "1" "548" "61.2" "6.07" "7.00" "2" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00168, Pf07002" "221184" "ENSG00000140848" "CPNE2" "hsa:221184; Q68D19; Q719H8; Q86XP9; Q96FN4" "" "" "0" "0" "0.891" "1.094" "1.034" "1.034" "1.146" "1.045" "1.074" "0.913" "1.058" "92.3" "82.3" "100.9" "95.4" "95.4" "105.8" "96.4" "99.1" "84.2" "97.6" "" "" "" "" "" "" "" "" "" "" "92.3" "69.6" "63.8" "69.6" "78.2" "82.1" "74.3" "85.2" "65.7" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "845773514533919097" "False" "High" "IsMasterProtein" "Q9Y365" "START domain-containing protein 10 OS=Homo sapiens OX=9606 GN=STARD10 PE=1 SV=2" "0.000" "False" "7.089" "10" "2" "2" "2" "291" "33.0" "7.12" "4.19" "2" "transport" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01852" "10809" "ENSG00000214530" "STARD10" "hsa:10809; O60532; Q9Y365" "" "Synthesis of PC" "1" "0" "1.103" "1.023" "1.025" "1.149" "0.971" "1.190" "1.084" "0.966" "0.737" "47.3" "52.1" "48.4" "48.4" "54.3" "45.9" "56.2" "51.2" "45.7" "34.8" "" "" "" "" "" "" "" "" "" "" "47.3" "44.1" "30.6" "35.3" "44.5" "35.6" "43.3" "44.0" "35.6" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2486972886246464504" "False" "High" "IsMasterProtein" "O00221" "NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3" "0.000" "False" "7.085" "4" "1" "1" "1" "500" "52.8" "6.68" "4.88" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00023" "4794" "ENSG00000146232" "NFKBIE" "hsa:4794; O00221; Q5T9V9" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19" "Activation of NF-kappaB in B cells" "7" "0" "1.413" "1.046" "1.478" "1.389" "1.229" "1.453" "1.110" "1.085" "1.023" "41.1" "58.1" "43.0" "60.7" "57.1" "50.5" "59.7" "45.6" "44.6" "42.0" "" "" "" "" "" "" "" "" "" "" "41.1" "49.1" "27.2" "44.3" "46.8" "39.2" "46.0" "39.2" "34.8" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "213953215988823024" "False" "High" "IsMasterProtein" "Q92896" "Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2" "0.000" "False" "7.084" "2" "2" "2" "2" "1179" "134.5" "6.90" "6.01" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytoskeleton;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00839" "2734" "ENSG00000090863" "GLG1" "B7Z8Y4; D3DUJ7; hsa:2734; Q13221; Q6P9D1; Q92896" "" "Cell surface interactions at the vascular wall" "1" "0" "1.062" "1.133" "1.041" "1.073" "1.177" "1.233" "1.260" "1.174" "1.202" "56.3" "59.7" "63.7" "58.5" "60.4" "66.2" "69.4" "70.9" "66.0" "67.6" "" "" "" "" "" "" "" "" "" "" "56.3" "50.5" "40.3" "42.7" "49.5" "51.4" "53.5" "60.9" "51.5" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "7.083" "5" "2" "2" "2" "349" "38.7" "5.78" "6.42" "2" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "High" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.000" "False" "7.082" "2" "2" "3" "2" "1162" "129.5" "8.37" "10.06" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "" "2" "0" "0.928" "0.802" "1.058" "0.984" "0.887" "1.007" "1.037" "0.841" "0.980" "123.7" "114.8" "99.2" "130.9" "121.8" "109.7" "124.6" "128.3" "104.0" "121.3" "" "" "" "" "" "" "" "" "" "" "123.7" "97.1" "62.8" "95.5" "99.8" "85.2" "96.0" "110.3" "81.2" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7737181066118710012" "False" "High" "IsMasterProtein" "Q8TB40" "(Lyso)-N-acylphosphatidylethanolamine lipase OS=Homo sapiens OX=9606 GN=ABHD4 PE=1 SV=1" "0.000" "False" "7.074" "7" "2" "2" "2" "342" "38.8" "7.59" "6.53" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00561" "63874" "ENSG00000100439" "ABHD4" "B4DDH7; hsa:63874; Q8TB40; Q9H9E0" "" "Acyl chain remodelling of PE" "1" "0" "1.253" "0.989" "1.162" "1.155" "0.877" "1.164" "0.957" "0.965" "0.946" "68.5" "85.9" "67.7" "79.6" "79.2" "60.0" "79.8" "65.6" "66.1" "64.8" "" "" "" "" "" "" "" "" "" "" "68.5" "72.6" "42.8" "58.1" "64.9" "46.6" "61.5" "56.4" "51.6" "58.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3742199827484990276" "False" "High" "IsMasterProtein" "P53667" "LIM domain kinase 1 OS=Homo sapiens OX=9606 GN=LIMK1 PE=1 SV=3" "0.000" "False" "7.067" "3" "2" "2" "2" "647" "72.5" "6.98" "6.75" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3984" "ENSG00000106683" "LIMK1" "B7Z6I8; D3DXF4; D3DXF5; hsa:3984; O15283; P53667; Q15820; Q15821; Q75MU3; Q9Y5Q1" "Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "12" "0" "0.998" "0.777" "0.854" "1.186" "0.829" "0.838" "1.024" "0.754" "0.839" "67.3" "67.2" "52.3" "57.5" "79.8" "55.8" "56.4" "68.9" "50.8" "56.5" "" "" "" "" "" "" "" "" "" "" "67.3" "56.8" "33.1" "41.9" "65.4" "43.4" "43.5" "59.3" "39.6" "50.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "7.065" "2" "2" "2" "2" "1114" "124.0" "6.71" "6.18" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "0.882" "0.805" "1.221" "1.365" "1.066" "1.063" "1.389" "1.027" "1.092" "17.0" "15.0" "13.7" "20.7" "23.2" "18.1" "18.1" "23.6" "17.4" "18.6" "" "" "" "" "" "" "" "" "" "" "17.0" "12.7" "8.7" "15.1" "19.0" "14.1" "13.9" "20.3" "13.6" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4864862303047708944" "False" "High" "IsMasterProtein" "P52630" "Signal transducer and activator of transcription 2 OS=Homo sapiens OX=9606 GN=STAT2 PE=1 SV=1" "0.000" "False" "7.062" "3" "3" "3" "3" "851" "97.9" "5.49" "8.45" "3" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12188, Pf21354" "6773" "ENSG00000170581" "STAT2" "B4DLC7; G3V2M6; hsa:6773; P52630; Q16430; Q16431; Q9UDL4" "Type III interferon signaling; Adipogenesis; Chemokine signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Interferon type I signaling pathways; Type II interferon signaling" "Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of IFNA/IFNB signaling; Interleukin-20 family signaling; Evasion by RSV of host interferon responses" "21" "0" "1.010" "0.554" "0.852" "0.868" "0.469" "0.996" "1.092" "0.703" "0.865" "27.2" "27.4" "15.0" "23.1" "23.6" "12.7" "27.0" "29.7" "19.1" "23.5" "" "" "" "" "" "" "" "" "" "" "27.2" "23.2" "9.5" "16.9" "19.3" "9.9" "20.8" "25.5" "14.9" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2465041974174611566" "False" "High" "IsMasterProtein" "Q96BT7" "Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens OX=9606 GN=ALKBH8 PE=1 SV=2" "0.000" "False" "7.061" "4" "3" "3" "3" "664" "75.2" "7.99" "7.67" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08241, Pf09004, Pf13532" "91801" "ENSG00000137760" "ALKBH8" "B1Q2M0; B4DEF6; hsa:91801; Q8N989; Q96BT7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.063" "0.837" "1.162" "1.098" "1.032" "1.170" "1.156" "0.978" "1.159" "191.5" "203.6" "160.2" "222.5" "210.3" "197.6" "224.0" "221.3" "187.2" "222.0" "" "" "" "" "" "" "" "" "" "" "191.5" "172.3" "101.3" "162.2" "172.3" "153.4" "172.6" "190.3" "146.1" "199.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "7.060" "9" "2" "2" "2" "225" "25.7" "9.25" "6.50" "2" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "0.992" "1.035" "1.303" "1.015" "1.138" "1.295" "0.981" "1.118" "1.042" "104.4" "103.6" "108.1" "136.0" "106.0" "118.8" "135.2" "102.4" "116.7" "108.7" "" "" "" "" "" "" "" "" "" "" "104.4" "87.6" "68.3" "99.2" "86.8" "92.3" "104.2" "88.0" "91.1" "97.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766075774548217970" "False" "High" "IsMasterProtein" "Q8IW19" "Aprataxin and PNK-like factor OS=Homo sapiens OX=9606 GN=APLF PE=1 SV=1" "0.000" "False" "7.055" "4" "2" "3" "2" "511" "56.9" "5.08" "8.74" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10283, Pf17913" "200558" "ENSG00000169621" "APLF" "A8K476; hsa:200558; Q53P47; Q53PB9; Q53QU0; Q8IW19" "" "" "0" "0" "1.167" "0.540" "1.099" "0.842" "0.709" "1.015" "1.083" "0.897" "1.212" "26.4" "30.8" "14.2" "29.0" "22.2" "18.7" "26.8" "28.6" "23.7" "32.0" "" "" "" "" "" "" "" "" "" "" "26.4" "26.1" "9.0" "21.2" "18.2" "14.5" "20.7" "24.6" "18.5" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115267819831113520" "False" "High" "IsMasterProtein" "Q8IX18" "Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2" "0.000" "False" "7.052" "2" "2" "2" "2" "779" "88.5" "8.65" "4.94" "2" "" "" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "79665" "ENSG00000108406" "DHX40" "B3KTJ5; C9JR60; hsa:79665; Q5JPH4; Q8IX18; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "7.051" "10" "1" "1" "1" "252" "25.4" "9.88" "6.47" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "0.788" "1.090" "1.046" "0.787" "1.033" "1.059" "1.038" "0.996" "0.961" "15.0" "11.9" "16.4" "15.7" "11.8" "15.5" "15.9" "15.6" "15.0" "14.4" "" "" "" "" "" "" "" "" "" "" "15.0" "10.0" "10.4" "11.5" "9.7" "12.1" "12.3" "13.4" "11.7" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.000" "False" "7.034" "2" "2" "2" "2" "1064" "115.3" "6.29" "6.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "1.034" "0.852" "1.092" "1.249" "0.887" "1.003" "1.181" "0.910" "0.912" "119.2" "123.2" "101.6" "130.2" "148.9" "105.8" "119.5" "140.7" "108.5" "108.7" "" "" "" "" "" "" "" "" "" "" "119.2" "104.2" "64.2" "94.9" "122.0" "82.1" "92.1" "121.0" "84.7" "97.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "7.026" "8" "2" "2" "2" "265" "28.6" "5.48" "6.08" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.019" "1.113" "1.110" "0.972" "1.344" "1.140" "1.059" "1.082" "1.059" "79.9" "81.5" "89.0" "88.7" "77.7" "107.5" "91.1" "84.7" "86.5" "84.7" "" "" "" "" "" "" "" "" "" "" "79.9" "68.9" "56.3" "64.7" "63.6" "83.5" "70.2" "72.8" "67.5" "76.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4572995838386066943" "False" "High" "IsMasterProtein" "Q13568" "Interferon regulatory factor 5 OS=Homo sapiens OX=9606 GN=IRF5 PE=1 SV=2" "0.000" "False" "7.014" "5" "2" "2" "2" "498" "56.0" "5.77" "5.26" "2" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3663" "ENSG00000128604" "IRF5" "A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54; hsa:3663; Q13568; Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0" "Apoptosis; Vitamin D receptor pathway; miRNA role in immune response in sepsis; p53 transcriptional gene network; Genes associated with the development of rheumatoid arthritis; Orexin receptor pathway; Toll-like receptor signaling pathway" "Interferon gamma signaling; Interferon alpha/beta signaling" "9" "0" "1.280" "1.138" "1.218" "1.222" "1.128" "1.258" "1.214" "1.017" "1.220" "99.5" "127.3" "113.2" "121.2" "121.5" "112.2" "125.1" "120.8" "101.2" "121.4" "" "" "" "" "" "" "" "" "" "" "99.5" "107.7" "71.5" "88.4" "99.6" "87.1" "96.4" "103.8" "79.0" "109.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.000" "False" "7.000" "3" "2" "2" "2" "658" "73.7" "8.18" "6.40" "2" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "PPARA activates gene expression; Carnitine metabolism" "9" "0" "0.905" "0.907" "0.953" "1.119" "0.822" "0.929" "0.991" "0.927" "0.936" "93.2" "84.4" "84.5" "88.8" "104.3" "76.6" "86.5" "92.4" "86.4" "87.2" "" "" "" "" "" "" "" "" "" "" "93.2" "71.4" "53.4" "64.8" "85.4" "59.5" "66.7" "79.4" "67.5" "78.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "6.993" "11" "2" "4" "2" "167" "19.5" "4.49" "12.06" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "" "tRNA processing in the nucleus" "1" "0" "1.186" "1.079" "1.058" "1.139" "1.279" "1.174" "1.203" "1.158" "1.262" "43.7" "51.9" "47.2" "46.3" "49.8" "55.9" "51.4" "52.6" "50.7" "55.2" "" "" "" "" "" "" "" "" "" "" "43.7" "43.9" "29.8" "33.7" "40.8" "43.4" "39.6" "45.2" "39.5" "49.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "167158526121610019" "False" "High" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "0.000" "False" "6.989" "2" "2" "2" "2" "1226" "138.4" "6.15" "6.15" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "0.929" "0.882" "0.997" "1.093" "1.251" "1.334" "1.057" "0.912" "1.034" "63.3" "58.8" "55.9" "63.2" "69.2" "79.2" "84.5" "66.9" "57.8" "65.5" "" "" "" "" "" "" "" "" "" "" "63.3" "49.8" "35.3" "46.0" "56.7" "61.5" "65.1" "57.6" "45.1" "58.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "6.988" "5" "2" "2" "2" "388" "43.9" "8.53" "5.72" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "6.981" "4" "3" "3" "3" "727" "82.7" "6.96" "7.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "5" "0" "0.941" "0.775" "0.752" "0.901" "1.084" "1.189" "1.183" "0.879" "1.031" "33.6" "31.6" "26.1" "25.3" "30.3" "36.4" "40.0" "39.8" "29.6" "34.6" "" "" "" "" "" "" "" "" "" "" "33.6" "26.8" "16.5" "18.4" "24.8" "28.3" "30.8" "34.2" "23.1" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-464578960870386636" "False" "High" "IsMasterProtein" "O43639" "Cytoplasmic protein NCK2 OS=Homo sapiens OX=9606 GN=NCK2 PE=1 SV=2" "0.000" "False" "6.976" "6" "3" "3" "1" "380" "42.9" "6.95" "8.13" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf14604" "8440" "ENSG00000071051" "NCK2" "D3DVK1; hsa:8440; O43639; Q9BWN9; Q9UIC3" "Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway" "RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "866424040394030727" "False" "High" "IsMasterProtein" "Q15052" "Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6 PE=1 SV=2" "0.000" "False" "6.962" "3" "2" "2" "1" "776" "87.4" "6.05" "5.86" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16523, Pf16614, Pf16615" "9459" "ENSG00000129675" "ARHGEF6" "A6NMW9; A8K6S7; B1AL37; hsa:9459; Q15052; Q15396; Q5JQ66; Q7Z3W1; Q86XH0" "Pancreatic adenocarcinoma pathway; Regulation of actin cytoskeleton" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; G beta:gamma signalling through CDC42; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6238619609280539619" "False" "High" "IsMasterProtein" "Q9NZW5" "Protein PALS2 OS=Homo sapiens OX=9606 GN=PALS2 PE=1 SV=2" "0.000" "False" "6.957" "4" "2" "2" "2" "540" "61.1" "6.18" "6.34" "2" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "1.134" "1.040" "1.171" "1.042" "1.011" "1.074" "1.159" "1.009" "1.061" "83.4" "94.6" "86.7" "97.7" "86.9" "84.3" "89.6" "96.6" "84.1" "88.5" "" "" "" "" "" "" "" "" "" "" "83.4" "80.0" "54.8" "71.2" "71.2" "65.5" "69.1" "83.1" "65.7" "79.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3269351355245221217" "False" "High" "IsMasterProtein" "Q8NF37" "Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2" "0.000" "False" "6.956" "2" "1" "1" "1" "534" "59.1" "6.02" "3.76" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01553, Pf13833" "79888" "ENSG00000153395" "LPCAT1" "hsa:79888; Q1HAQ1; Q7Z4G6; Q8N3U7; Q8NF37; Q8WUL8; Q9GZW6" "" "Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC" "5" "0" "0.942" "0.802" "0.928" "0.891" "1.015" "0.869" "1.045" "0.916" "0.904" "57.3" "54.0" "46.0" "53.2" "51.1" "58.2" "49.8" "59.9" "52.5" "51.8" "" "" "" "" "" "" "" "" "" "" "57.3" "45.7" "29.1" "38.8" "41.8" "45.2" "38.4" "51.5" "41.0" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "6.952" "2" "2" "2" "2" "993" "107.5" "6.30" "6.77" "2" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4252967583247382756" "False" "High" "IsMasterProtein" "Q8N3K9" "Cardiomyopathy-associated protein 5 OS=Homo sapiens OX=9606 GN=CMYA5 PE=1 SV=3" "0.000" "False" "6.936" "1" "2" "2" "2" "4069" "448.9" "4.78" "5.31" "2" "" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf00041, Pf00622" "202333" "ENSG00000164309" "CMYA5" "A0PJB7; hsa:202333; Q05CT4; Q2NKX1; Q2T9G9; Q69YQ8; Q69YQ9; Q6P517; Q6P5U3; Q7Z4I1; Q86T34; Q86T49; Q8N3K9; Q8N3S4; Q8N3S7; Q8NAG8; Q9UK88" "" "" "0" "0" "1.146" "1.069" "0.841" "1.289" "0.721" "1.351" "1.138" "0.961" "0.932" "32.8" "37.5" "35.0" "27.5" "42.2" "23.6" "44.3" "37.3" "31.5" "30.5" "" "" "" "" "" "" "" "" "" "" "32.8" "31.8" "22.1" "20.1" "34.6" "18.3" "34.1" "32.1" "24.6" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "6.930" "7" "2" "2" "2" "276" "30.0" "5.30" "6.91" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "6.923" "5" "2" "4" "2" "421" "47.3" "6.84" "6.01" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "5" "0" "1.308" "1.007" "1.119" "1.456" "1.137" "1.476" "1.179" "0.826" "1.150" "78.7" "103.0" "79.3" "88.1" "114.6" "89.6" "116.2" "92.9" "65.0" "90.5" "" "" "" "" "" "" "" "" "" "" "78.7" "87.2" "50.1" "64.3" "93.9" "69.6" "89.6" "79.8" "50.7" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "6.905" "6" "2" "3" "2" "282" "31.8" "4.83" "7.94" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "6.899" "5" "3" "4" "3" "501" "55.8" "7.53" "10.38" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "37" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "6.896" "16" "2" "2" "2" "122" "13.3" "8.46" "7.29" "2" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.967" "0.940" "0.974" "1.042" "1.124" "1.136" "1.195" "0.954" "1.048" "65.8" "63.6" "61.8" "64.0" "68.5" "73.9" "74.7" "78.6" "62.7" "68.9" "" "" "" "" "" "" "" "" "" "" "65.8" "53.8" "39.1" "46.7" "56.1" "57.4" "57.6" "67.6" "49.0" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8265724560765906942" "False" "High" "IsMasterProtein" "Q9BVP2" "Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2" "0.000" "False" "6.893" "5" "4" "4" "4" "549" "62.0" "9.16" "11.38" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf08701" "26354" "ENSG00000163938" "GNL3" "B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.141" "0.745" "0.979" "1.048" "0.774" "1.027" "1.057" "0.750" "0.960" "688.4" "785.2" "512.6" "674.2" "721.2" "533.1" "707.1" "727.6" "516.0" "660.9" "" "" "" "" "" "" "" "" "" "" "688.4" "664.3" "324.2" "491.6" "590.9" "414.0" "545.0" "625.6" "402.7" "594.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "6.890" "5" "3" "3" "3" "659" "74.4" "6.74" "7.70" "3" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Genes related to primary cilium development (based on CRISPR)" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.064" "0.881" "1.102" "1.042" "1.028" "1.116" "1.154" "0.950" "1.012" "108.9" "115.8" "95.9" "120.0" "113.4" "112.0" "121.5" "125.7" "103.4" "110.2" "" "" "" "" "" "" "" "" "" "" "108.9" "98.0" "60.6" "87.5" "92.9" "87.0" "93.7" "108.1" "80.7" "99.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6161986969394420318" "False" "High" "IsMasterProtein" "O95081" "Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2" "0.000" "False" "6.889" "4" "2" "2" "2" "481" "48.9" "9.11" "7.05" "2" "" "other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "3268" "ENSG00000106351" "AGFG2" "hsa:3268; O75429; O95081; Q96AB9; Q96GL4" "" "" "0" "0" "0.987" "0.697" "0.976" "1.004" "0.828" "1.046" "0.989" "0.770" "0.818" "229.4" "226.3" "160.0" "223.7" "230.4" "189.8" "240.0" "226.9" "176.7" "187.7" "" "" "" "" "" "" "" "" "" "" "229.4" "191.4" "101.1" "163.1" "188.8" "147.4" "185.0" "195.1" "137.9" "168.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4865445723935678396" "False" "High" "IsMasterProtein" "Q13309" "S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2" "0.000" "False" "6.883" "5" "2" "2" "2" "424" "47.7" "7.11" "6.01" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12937" "6502" "ENSG00000145604" "SKP2" "A8K5E0; B4DJT4; hsa:6502; Q13309; Q8TDZ0; Q8TDZ1; Q9BV69" "Cell cycle; Retinoblastoma gene in cancer; Imatinib and chronic myeloid leukemia" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.000" "False" "6.873" "10" "2" "3" "2" "191" "20.9" "4.39" "9.81" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "High" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.000" "False" "6.871" "4" "2" "2" "2" "476" "53.5" "7.17" "6.17" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "1.146" "1.292" "1.334" "1.275" "1.092" "1.392" "1.256" "1.061" "1.149" "103.4" "118.4" "133.5" "137.9" "131.8" "112.8" "143.9" "129.9" "109.6" "118.7" "" "" "" "" "" "" "" "" "" "" "103.4" "100.2" "84.4" "100.6" "107.9" "87.6" "110.9" "111.7" "85.6" "106.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "6.868" "6" "4" "4" "4" "497" "55.8" "7.55" "11.05" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.992" "0.936" "0.900" "0.915" "0.891" "1.006" "0.906" "0.849" "0.991" "156.7" "155.4" "146.6" "141.0" "143.4" "139.6" "157.6" "142.0" "133.0" "155.2" "" "" "" "" "" "" "" "" "" "" "156.7" "131.5" "92.7" "102.8" "117.5" "108.4" "121.4" "122.1" "103.8" "139.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "6.867" "3" "2" "2" "2" "579" "65.5" "7.06" "5.45" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7925293955382701162" "False" "High" "IsMasterProtein" "Q96JN8" "Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2" "0.000" "False" "6.862" "2" "2" "2" "2" "1562" "166.8" "5.86" "6.44" "2" "" "cytoskeleton;other cell component" "other molecular function" "Pf07177" "84461" "ENSG00000215041; ENSG00000288301" "NEURL4" "hsa:84461; Q6GPI8; Q96IU9; Q96JN8; Q9H0B0" "" "" "0" "0" "0.987" "0.805" "0.935" "0.912" "0.732" "0.921" "0.947" "0.875" "0.959" "111.0" "109.6" "89.4" "103.8" "101.2" "81.3" "102.2" "105.1" "97.1" "106.5" "" "" "" "" "" "" "" "" "" "" "111.0" "92.7" "56.5" "75.7" "82.9" "63.1" "78.8" "90.4" "75.8" "95.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309589120852016759" "False" "High" "IsMasterProtein" "P54922" "ADP-ribosylhydrolase ARH1 OS=Homo sapiens OX=9606 GN=ADPRH PE=1 SV=1" "0.000" "False" "6.857" "10" "4" "5" "4" "357" "39.5" "6.52" "9.40" "4" "protein metabolism;other metabolic processes" "non-structural extracellular" "other molecular function" "Pf03747" "141" "ENSG00000144843" "ADPRH" "B2R8H1; D3DN83; hsa:141; P54922" "" "" "0" "0" "0.918" "1.072" "0.923" "0.872" "1.043" "0.932" "0.995" "1.068" "0.966" "329.9" "302.9" "353.5" "304.3" "287.5" "344.0" "307.4" "328.2" "352.5" "318.6" "" "" "" "" "" "" "" "" "" "" "329.9" "256.3" "223.5" "221.9" "235.5" "267.1" "236.9" "282.2" "275.1" "286.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7754032673472143678" "False" "High" "IsMasterProtein" "Q8TET4" "Neutral alpha-glucosidase C OS=Homo sapiens OX=9606 GN=GANC PE=1 SV=3" "0.000" "False" "6.850" "4" "2" "2" "2" "914" "104.3" "6.23" "5.71" "2" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf01055, Pf13802, Pf21365" "2595" "ENSG00000214013" "GANC" "hsa:2595; Q52LQ4; Q8IWZ0; Q8IZM4; Q8IZM5; Q8TET4" "Osteoarthritic chondrocyte hypertrophy" "" "1" "0" "0.974" "1.040" "0.903" "1.037" "0.973" "0.992" "1.086" "1.239" "0.976" "73.9" "71.9" "76.8" "66.7" "76.6" "71.9" "73.3" "80.2" "91.5" "72.1" "" "" "" "" "" "" "" "" "" "" "73.9" "60.8" "48.6" "48.6" "62.7" "55.8" "56.5" "69.0" "71.4" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "6.842" "5" "2" "2" "2" "403" "43.8" "5.78" "7.73" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "1.288" "1.053" "1.297" "1.091" "1.148" "1.154" "1.263" "1.083" "1.044" "56.0" "72.2" "59.0" "72.7" "61.1" "64.3" "64.6" "70.8" "60.7" "58.5" "" "" "" "" "" "" "" "" "" "" "56.0" "61.1" "37.3" "53.0" "50.1" "49.9" "49.8" "60.8" "47.4" "52.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "6.833" "2" "2" "2" "2" "963" "108.1" "6.44" "5.73" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "6.829" "4" "3" "3" "3" "590" "67.6" "5.02" "7.93" "3" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7376822484090122143" "False" "High" "IsMasterProtein" "P05166" "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" "0.000" "False" "6.813" "5" "3" "3" "3" "539" "58.2" "7.64" "8.27" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "5096" "ENSG00000114054" "PCCB" "B7Z2Z4; hsa:5096; P05166; Q16813; Q96CX0" "Primary ovarian insufficiency" "Biotin transport and metabolism; Mitochondrial protein degradation; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "5" "0" "1.165" "0.956" "0.995" "1.104" "1.046" "1.025" "1.071" "0.974" "0.986" "126.6" "147.5" "121.1" "126.1" "139.9" "132.5" "129.8" "135.7" "123.3" "124.9" "" "" "" "" "" "" "" "" "" "" "126.6" "124.8" "76.6" "91.9" "114.6" "102.9" "100.0" "116.7" "96.2" "112.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736163179168070894" "False" "High" "IsMasterProtein" "Q9Y2V7" "Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2" "0.000" "False" "6.812" "3" "2" "2" "2" "657" "73.2" "5.76" "6.92" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06419, Pf20653" "57511" "ENSG00000133103" "COG6" "hsa:57511; Q5T0U1; Q6AI19; Q86V49; Q9ULT5; Q9Y2V7" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.889" "0.769" "0.930" "1.015" "0.879" "1.036" "0.916" "0.860" "0.987" "120.8" "107.4" "92.9" "112.3" "122.6" "106.2" "125.1" "110.6" "103.9" "119.2" "" "" "" "" "" "" "" "" "" "" "120.8" "90.8" "58.7" "81.9" "100.5" "82.5" "96.5" "95.1" "81.1" "107.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "High" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.000" "False" "6.806" "12" "2" "2" "2" "195" "21.4" "8.24" "5.92" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.868" "0.650" "0.868" "0.983" "0.796" "1.023" "0.906" "0.770" "0.868" "78.0" "67.7" "50.6" "67.7" "76.7" "62.1" "79.8" "70.7" "60.0" "67.7" "" "" "" "" "" "" "" "" "" "" "78.0" "57.3" "32.0" "49.4" "62.8" "48.2" "61.5" "60.8" "46.9" "60.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "6.798" "1" "2" "2" "2" "2229" "242.8" "8.34" "6.77" "2" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "0.850" "0.868" "1.288" "1.115" "0.924" "0.893" "0.934" "1.347" "1.020" "30.0" "25.5" "26.0" "38.6" "33.4" "27.7" "26.8" "28.0" "40.4" "30.6" "" "" "" "" "" "" "" "" "" "" "30.0" "21.5" "16.4" "28.1" "27.4" "21.5" "20.6" "24.0" "31.5" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "6.797" "6" "3" "3" "3" "445" "48.1" "7.12" "8.29" "3" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "3" "0" "0.939" "1.010" "0.921" "1.035" "0.947" "1.080" "1.065" "1.007" "0.887" "81.3" "76.3" "82.1" "74.9" "84.2" "77.0" "87.8" "86.6" "81.9" "72.1" "" "" "" "" "" "" "" "" "" "" "81.3" "64.6" "51.9" "54.6" "69.0" "59.8" "67.7" "74.4" "63.9" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7568231581715943755" "False" "High" "IsMasterProtein" "Q7Z333" "Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4" "0.000" "False" "6.789" "1" "2" "2" "2" "2677" "302.7" "7.17" "6.30" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087" "23064" "ENSG00000107290" "SETX" "A2A396; B2RPB2; B5ME16; C9JQ10; hsa:23064; O75120; Q3KQX4; Q5JUJ1; Q68DW5; Q6AZD7; Q7Z333; Q7Z3J6; Q8WX33; Q9H9D1; Q9NVP9" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "0.864" "0.744" "0.960" "0.982" "0.736" "0.914" "0.977" "0.772" "0.774" "96.6" "83.4" "71.8" "92.7" "94.8" "71.1" "88.3" "94.3" "74.5" "74.7" "" "" "" "" "" "" "" "" "" "" "96.6" "70.6" "45.4" "67.6" "77.7" "55.2" "68.0" "81.1" "58.2" "67.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457193127181059495" "False" "High" "IsMasterProtein" "Q8TDR0" "TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1" "0.000" "False" "6.774" "4" "3" "3" "3" "691" "78.6" "7.93" "4.59" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf10243, Pf17749" "26146" "ENSG00000204104" "TRAF3IP1" "hsa:26146; Q6PCT1; Q7L8N9; Q8TDR0; Q9NRD6; Q9Y4Q1" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 2q37 copy number variation syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "6" "0" "0.983" "0.976" "1.110" "1.210" "1.115" "1.077" "1.155" "0.975" "0.855" "26.7" "26.3" "26.1" "29.7" "32.3" "29.8" "28.8" "30.8" "26.0" "22.8" "" "" "" "" "" "" "" "" "" "" "26.7" "22.2" "16.5" "21.6" "26.5" "23.1" "22.2" "26.5" "20.3" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "6.768" "3" "2" "2" "2" "781" "89.3" "5.99" "7.80" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.108" "1.131" "1.261" "0.867" "1.083" "0.975" "1.031" "0.905" "0.906" "30.9" "34.3" "35.0" "39.0" "26.8" "33.5" "30.2" "31.9" "28.0" "28.0" "" "" "" "" "" "" "" "" "" "" "30.9" "29.0" "22.1" "28.5" "22.0" "26.0" "23.3" "27.4" "21.9" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7795104145569461525" "False" "High" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "0.000" "False" "6.756" "2" "2" "2" "2" "1173" "136.3" "7.44" "6.70" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "1.131" "1.064" "1.080" "0.992" "0.944" "1.039" "1.024" "0.897" "0.931" "75.8" "85.8" "80.7" "81.9" "75.3" "71.6" "78.8" "77.7" "68.0" "70.6" "" "" "" "" "" "" "" "" "" "" "75.8" "72.6" "51.0" "59.7" "61.7" "55.6" "60.8" "66.8" "53.1" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8722569096218095971" "False" "High" "IsMasterProtein" "Q9NVN3" "Synembryn-B OS=Homo sapiens OX=9606 GN=RIC8B PE=1 SV=2" "0.000" "False" "6.752" "3" "2" "2" "2" "520" "58.8" "5.73" "5.34" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "55188" "ENSG00000111785" "RIC8B" "A2RTZ0; hsa:55188; Q4G103; Q6ZRN4; Q86WD3; Q9NVN3" "" "" "0" "0" "0.998" "0.870" "1.083" "1.024" "0.838" "1.091" "1.058" "0.931" "0.985" "139.2" "138.9" "121.1" "150.8" "142.5" "116.7" "151.9" "147.4" "129.7" "137.2" "" "" "" "" "" "" "" "" "" "" "139.2" "117.6" "76.6" "110.0" "116.8" "90.6" "117.1" "126.7" "101.2" "123.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.000" "False" "6.722" "24" "1" "1" "1" "103" "11.6" "7.43" "4.52" "1" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "" "Mitochondrial protein import" "1" "0" "1.151" "0.802" "1.062" "0.989" "0.771" "1.201" "0.976" "0.723" "1.075" "23.3" "26.8" "18.7" "24.8" "23.1" "18.0" "28.0" "22.8" "16.9" "25.1" "" "" "" "" "" "" "" "" "" "" "23.3" "22.7" "11.8" "18.1" "18.9" "14.0" "21.6" "19.6" "13.2" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330394968015135701" "False" "High" "IsMasterProtein" "Q9P2R3" "Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2" "0.000" "False" "6.719" "2" "2" "2" "2" "1169" "128.3" "6.10" "5.05" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00023, Pf00651, Pf01363, Pf12796" "51479" "ENSG00000185722" "ANKFY1" "A8KA65; hsa:51479; Q5RKV4; Q9P2R3; Q9ULG5" "" "RHOD GTPase cycle" "1" "0" "1.065" "0.922" "1.061" "1.027" "0.897" "0.981" "1.038" "0.986" "1.018" "116.8" "124.5" "107.7" "124.0" "120.0" "104.8" "114.6" "121.3" "115.3" "118.9" "" "" "" "" "" "" "" "" "" "" "116.8" "105.3" "68.1" "90.4" "98.3" "81.4" "88.3" "104.3" "90.0" "106.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.000" "False" "6.717" "3" "2" "2" "2" "617" "67.7" "8.56" "6.43" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.058" "0.842" "1.050" "1.031" "0.783" "1.028" "0.982" "1.008" "0.914" "74.6" "79.0" "62.8" "78.4" "76.9" "58.5" "76.7" "73.3" "75.3" "68.2" "" "" "" "" "" "" "" "" "" "" "74.6" "66.8" "39.7" "57.1" "63.0" "45.4" "59.1" "63.0" "58.7" "61.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786161686779775583" "False" "High" "IsMasterProtein" "B4DXR9" "Zinc finger protein 732 OS=Homo sapiens OX=9606 GN=ZNF732 PE=2 SV=1" "0.000" "False" "6.714" "2" "1" "2" "1" "585" "67.8" "8.98" "5.90" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "654254" "ENSG00000186777" "ZNF732" "B4DXR9; hsa:654254" "" "Generic Transcription Pathway" "1" "0" "1.113" "1.002" "1.103" "1.148" "0.897" "1.254" "1.243" "0.996" "1.180" "78.2" "87.0" "78.3" "86.3" "89.8" "70.2" "98.1" "97.2" "77.9" "92.3" "" "" "" "" "" "" "" "" "" "" "78.2" "73.6" "49.5" "62.9" "73.6" "54.5" "75.6" "83.6" "60.8" "83.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610986345004973856" "False" "High" "IsMasterProtein" "P82664" "Small ribosomal subunit protein uS10m OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "0.000" "False" "6.707" "9" "2" "2" "2" "201" "23.0" "8.00" "6.77" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "" "Mitochondrial protein degradation; Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "4" "0" "1.163" "0.933" "1.335" "1.215" "1.020" "1.193" "1.226" "1.018" "1.262" "63.4" "73.7" "59.2" "84.7" "77.1" "64.7" "75.6" "77.7" "64.6" "80.0" "" "" "" "" "" "" "" "" "" "" "63.4" "62.4" "37.4" "61.7" "63.1" "50.2" "58.3" "66.8" "50.4" "71.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "6.699" "23" "2" "3" "1" "84" "9.5" "9.45" "10.18" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "25" "1" "1.016" "1.162" "1.155" "1.150" "1.229" "1.223" "1.169" "1.170" "1.021" "154.8" "157.3" "179.9" "178.9" "178.1" "190.3" "189.4" "181.0" "181.1" "158.1" "" "" "" "" "" "" "" "" "" "" "154.8" "133.1" "113.8" "130.4" "145.9" "147.7" "146.0" "155.6" "141.4" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.000" "False" "6.698" "3" "2" "3" "2" "612" "68.4" "5.20" "8.58" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "1.059" "0.823" "1.063" "0.997" "0.869" "1.147" "1.167" "0.865" "0.927" "124.8" "132.2" "102.7" "132.6" "124.3" "108.4" "143.1" "145.6" "108.0" "115.7" "" "" "" "" "" "" "" "" "" "" "124.8" "111.8" "65.0" "96.7" "101.9" "84.2" "110.3" "125.2" "84.3" "104.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2767038677570436707" "False" "High" "IsMasterProtein" "P82663" "Small ribosomal subunit protein mS25 OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "0.000" "False" "6.693" "13" "2" "2" "2" "173" "20.1" "8.82" "6.90" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.943" "1.014" "1.001" "1.034" "0.835" "1.021" "0.916" "0.908" "0.985" "176.2" "166.1" "178.7" "176.4" "182.2" "147.1" "179.9" "161.4" "160.0" "173.5" "" "" "" "" "" "" "" "" "" "" "176.2" "140.5" "113.0" "128.6" "149.3" "114.3" "138.7" "138.8" "124.9" "156.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "6.688" "10" "2" "2" "2" "167" "18.0" "9.48" "6.11" "2" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Iron-sulfur cluster biogenesis" "Maturation of replicase proteins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "6.667" "3" "2" "2" "2" "789" "86.6" "6.54" "4.82" "2" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "16" "0" "0.887" "0.735" "1.014" "0.935" "0.900" "0.888" "0.883" "0.941" "1.100" "137.5" "122.0" "101.1" "139.4" "128.6" "123.7" "122.1" "121.5" "129.4" "151.2" "" "" "" "" "" "" "" "" "" "" "137.5" "103.2" "63.9" "101.6" "105.4" "96.1" "94.1" "104.4" "101.0" "136.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1168608704850779616" "False" "High" "IsMasterProtein" "Q9BZV1" "UBX domain-containing protein 6 OS=Homo sapiens OX=9606 GN=UBXN6 PE=1 SV=1" "0.000" "False" "6.666" "5" "2" "3" "2" "441" "49.7" "6.89" "9.68" "2" "protein metabolism;other metabolic processes;stress response;transport" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00789, Pf09409" "80700" "ENSG00000167671" "UBXN6" "D6W626; hsa:80700; Q96AH1; Q96IK9; Q9BZV0; Q9BZV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "6.660" "7" "2" "2" "2" "257" "29.4" "9.67" "7.08" "2" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-754227750452775739" "False" "High" "IsMasterProtein" "Q96JI7" "Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=3" "0.000" "False" "6.659" "1" "3" "3" "3" "2443" "278.7" "5.97" "8.64" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14649" "80208" "ENSG00000104133" "SPG11" "A8KAX9; B9EK60; F5H3N6; Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q96JI7; Q9H734" "" "" "0" "0" "1.149" "0.918" "1.113" "1.107" "0.898" "1.066" "1.277" "0.948" "1.064" "126.4" "145.1" "116.0" "140.6" "139.9" "113.5" "134.7" "161.3" "119.8" "134.4" "" "" "" "" "" "" "" "" "" "" "126.4" "122.8" "73.3" "102.5" "114.6" "88.2" "103.8" "138.7" "93.5" "120.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "6.658" "3" "2" "3" "1" "526" "57.5" "7.33" "9.66" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "" "3" "0" "0.873" "1.005" "1.026" "1.065" "1.091" "1.082" "1.073" "1.056" "0.991" "372.7" "325.2" "374.5" "382.6" "397.1" "406.6" "403.1" "399.8" "393.6" "369.3" "" "" "" "" "" "" "" "" "" "" "372.7" "275.2" "236.8" "279.0" "325.3" "315.8" "310.8" "343.8" "307.3" "332.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4099473831415028291" "False" "High" "IsMasterProtein" "Q15011" "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1" "0.000" "False" "6.654" "5" "2" "2" "2" "391" "43.7" "5.25" "5.48" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00240" "9709" "ENSG00000051108" "HERPUD1" "E9PGD1; hsa:9709; O60644; Q15011; Q6IAN8; Q96D92" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "ATF4 activates genes in response to endoplasmic reticulum stress" "3" "0" "0.952" "1.130" "1.170" "1.094" "0.985" "1.093" "1.057" "0.800" "1.178" "28.3" "26.9" "31.9" "33.1" "30.9" "27.9" "30.9" "29.9" "22.6" "33.3" "" "" "" "" "" "" "" "" "" "" "28.3" "22.8" "20.2" "24.1" "25.3" "21.6" "23.8" "25.7" "17.7" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "6.648" "18" "2" "2" "2" "184" "20.3" "8.22" "5.62" "2" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "" "Complex I biogenesis" "1" "0" "1.028" "0.966" "0.769" "1.072" "1.267" "1.153" "0.927" "1.168" "1.021" "40.5" "41.6" "39.1" "31.1" "43.4" "51.3" "46.7" "37.5" "47.3" "41.3" "" "" "" "" "" "" "" "" "" "" "40.5" "35.2" "24.7" "22.7" "35.6" "39.8" "36.0" "32.3" "36.9" "37.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629743064100226613" "False" "High" "IsMasterProtein" "Q8TAK5" "GA-binding protein subunit beta-2 OS=Homo sapiens OX=9606 GN=GABPB2 PE=1 SV=1" "0.000" "False" "6.644" "5" "2" "2" "2" "448" "48.6" "5.26" "7.32" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796" "126626" "ENSG00000143458" "GABPB2" "B1AVJ8; D3DV14; hsa:126626; Q8NAR5; Q8TAK5" "" "" "0" "0" "0.863" "0.612" "0.985" "1.142" "1.069" "0.792" "1.030" "1.062" "0.816" "31.1" "26.8" "19.0" "30.6" "35.5" "33.2" "24.6" "32.0" "33.0" "25.3" "" "" "" "" "" "" "" "" "" "" "31.1" "22.7" "12.0" "22.3" "29.1" "25.8" "19.0" "27.5" "25.7" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "6.643" "3" "1" "1" "1" "424" "44.4" "8.56" "4.51" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA processing; 10q22q23 copy number variation" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "1.044" "1.209" "0.853" "1.112" "1.154" "1.046" "0.988" "1.020" "1.059" "110.2" "115.1" "133.2" "94.0" "122.5" "127.2" "115.3" "108.8" "112.4" "116.7" "" "" "" "" "" "" "" "" "" "" "110.2" "97.3" "84.2" "68.5" "100.4" "98.7" "88.9" "93.6" "87.7" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "6.643" "6" "2" "2" "2" "416" "44.5" "5.40" "5.63" "2" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "1.013" "1.171" "1.206" "1.214" "1.122" "1.268" "0.947" "1.234" "1.180" "54.7" "55.5" "64.1" "66.0" "66.5" "61.4" "69.4" "51.8" "67.6" "64.6" "" "" "" "" "" "" "" "" "" "" "54.7" "46.9" "40.5" "48.1" "54.5" "47.7" "53.5" "44.6" "52.7" "58.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "6.636" "6" "2" "2" "1" "347" "35.2" "7.37" "7.16" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; Estrogen-dependent gene expression" "14" "0" "1.301" "1.079" "1.253" "1.238" "1.176" "1.304" "1.108" "1.037" "1.180" "74.5" "96.9" "80.4" "93.4" "92.2" "87.7" "97.1" "82.6" "77.2" "87.9" "" "" "" "" "" "" "" "" "" "" "74.5" "82.0" "50.8" "68.1" "75.6" "68.1" "74.9" "71.0" "60.3" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3894590141980117731" "False" "High" "IsMasterProtein" "Q9NR55" "Basic leucine zipper transcriptional factor ATF-like 3 OS=Homo sapiens OX=9606 GN=BATF3 PE=1 SV=1" "0.000" "False" "6.616" "18" "1" "1" "1" "127" "14.5" "8.94" "4.36" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "55509" "ENSG00000123685" "BATF3" "hsa:55509; Q9NR55" "Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "6.616" "2" "1" "2" "1" "482" "55.8" "6.48" "6.00" "1" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "6.610" "3" "2" "4" "2" "652" "70.7" "7.90" "11.75" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "" "Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis" "4" "0" "1.262" "1.128" "1.068" "1.276" "1.191" "1.194" "1.095" "1.180" "1.108" "88.6" "111.8" "99.9" "94.6" "113.0" "105.5" "105.8" "97.0" "104.5" "98.1" "" "" "" "" "" "" "" "" "" "" "88.6" "94.6" "63.2" "69.0" "92.6" "81.9" "81.5" "83.4" "81.6" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021135707239228724" "False" "High" "IsMasterProtein" "Q92664" "Transcription factor IIIA OS=Homo sapiens OX=9606 GN=GTF3A PE=1 SV=3" "0.000" "False" "6.606" "4" "2" "2" "2" "365" "41.5" "9.14" "6.59" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "2971" "ENSG00000122034" "GTF3A" "B7ZBK5; hsa:2971; Q12963; Q13097; Q92664" "Adipogenesis" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3798154804985713391" "False" "High" "IsMasterProtein" "P41229" "Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2" "0.000" "False" "6.605" "1" "2" "2" "2" "1560" "175.6" "5.58" "5.33" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "8242" "ENSG00000126012" "KDM5C" "B0QZ44; B4E3I2; F5H3T1; hsa:8242; P41229; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5" "Clear cell renal cell carcinoma pathways" "HDMs demethylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "6.596" "7" "2" "2" "2" "332" "38.4" "6.40" "6.88" "2" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "0.849" "0.799" "0.722" "1.089" "0.652" "1.011" "0.671" "0.661" "1.039" "15.1" "12.8" "12.0" "10.9" "16.4" "9.8" "15.2" "10.1" "10.0" "15.6" "" "" "" "" "" "" "" "" "" "" "15.1" "10.8" "7.6" "7.9" "13.4" "7.6" "11.7" "8.7" "7.8" "14.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.000" "False" "6.596" "3" "1" "1" "1" "402" "46.4" "6.99" "4.34" "1" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "0.970" "0.753" "0.890" "0.934" "0.773" "0.867" "0.909" "0.760" "1.072" "70.4" "68.3" "53.0" "62.7" "65.8" "54.5" "61.0" "64.0" "53.5" "75.5" "" "" "" "" "" "" "" "" "" "" "70.4" "57.8" "33.5" "45.7" "53.9" "42.3" "47.0" "55.1" "41.8" "67.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "6.592" "6" "2" "2" "2" "338" "37.9" "7.42" "2.99" "2" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4270729495226616365" "False" "High" "IsMasterProtein" "Q9Y535" "DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens OX=9606 GN=POLR3H PE=1 SV=1" "0.000" "False" "6.587" "14" "1" "1" "1" "204" "22.9" "4.58" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03876, Pf08292" "171568" "ENSG00000100413" "POLR3H" "B0QYH9; hsa:171568; Q5M7Y8; Q96AE3; Q9BY95; Q9Y535" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; Primary ovarian insufficiency" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717347442497409014" "False" "High" "IsMasterProtein" "Q9NXF7" "DDB1- and CUL4-associated factor 16 OS=Homo sapiens OX=9606 GN=DCAF16 PE=1 SV=1" "0.000" "False" "6.583" "10" "2" "2" "2" "216" "24.2" "6.04" "5.62" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf15349" "54876" "ENSG00000163257" "DCAF16" "B3KPB7; hsa:54876; Q9NXF7" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053349268782207138" "False" "High" "IsMasterProtein" "Q8IYR2" "SET and MYND domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SMYD4 PE=1 SV=3" "0.000" "False" "6.582" "2" "2" "2" "2" "804" "89.2" "6.83" "5.86" "2" "other metabolic processes;developmental processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "114826" "ENSG00000186532" "SMYD4" "hsa:114826; Q8IYR2; Q8N1P2; Q8NAT0; Q96LV4; Q96PV2" "Histone modifications" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "6.567" "15" "2" "2" "2" "137" "15.3" "9.50" "6.08" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.035" "0.903" "1.126" "1.235" "1.181" "1.058" "1.279" "1.012" "0.890" "38.5" "39.8" "34.7" "43.3" "47.5" "45.4" "40.7" "49.2" "38.9" "34.2" "" "" "" "" "" "" "" "" "" "" "38.5" "33.7" "22.0" "31.6" "38.9" "35.3" "31.4" "42.3" "30.4" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "6.565" "16" "3" "4" "3" "145" "17.2" "10.55" "11.54" "3" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.880" "1.201" "0.983" "0.999" "1.317" "1.083" "1.249" "1.243" "1.083" "197.5" "173.8" "237.2" "194.2" "197.3" "260.2" "214.0" "246.7" "245.6" "213.8" "" "" "" "" "" "" "" "" "" "" "197.5" "147.0" "150.0" "141.6" "161.7" "202.0" "164.9" "212.1" "191.7" "192.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "6.565" "20" "2" "4" "1" "89" "10.3" "7.37" "12.45" "2" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; HCMV Early Events; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BMF and translocation to mitochondria" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.000" "False" "6.551" "1" "2" "2" "2" "2078" "232.6" "5.76" "5.33" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "6.536" "14" "2" "2" "2" "124" "13.6" "7.34" "6.80" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "Neutrophil degranulation; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; MAP2K and MAPK activation; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "13" "0" "1.017" "1.269" "0.907" "0.966" "1.260" "1.017" "0.886" "1.334" "1.144" "83.3" "84.8" "105.8" "75.6" "80.5" "105.0" "84.7" "73.8" "111.2" "95.3" "" "" "" "" "" "" "" "" "" "" "83.3" "71.7" "66.9" "55.1" "66.0" "81.5" "65.3" "63.5" "86.8" "85.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "6.536" "3" "2" "2" "1" "654" "67.6" "6.47" "7.70" "2" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "9" "0" "1.121" "1.019" "1.304" "1.083" "1.143" "1.206" "1.163" "0.910" "1.073" "103.3" "115.8" "105.2" "134.7" "111.9" "118.0" "124.6" "120.1" "94.0" "110.9" "" "" "" "" "" "" "" "" "" "" "103.3" "98.0" "66.5" "98.2" "91.7" "91.7" "96.0" "103.3" "73.3" "99.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200242617848963307" "False" "High" "IsMasterProtein" "P31749" "RAC-alpha serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT1 PE=1 SV=2" "0.000" "False" "6.523" "5" "2" "2" "2" "480" "55.7" "6.07" "5.55" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "207" "ENSG00000142208" "AKT1" "B2RAM5; B7Z5R1; hsa:207; P31749; Q9BWB6" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; S1P receptor signal transduction; Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Endochondral ossification; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; 3q29 copy number variation syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Opioid receptor pathways; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; Roles of ceramides in development of insulin resistance; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Comprehensive IL-17A signaling; Acute myeloid leukemia; Sildenafil treatment; Primary ovarian insufficiency; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response; Estrogen signaling pathway; Toll-like receptor signaling pathway" "Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; Interleukin-4 and Interleukin-13 signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Integrin signaling; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; MTOR signalling; FLT3 Signaling; eNOS activation; Regulation of TP53 Activity through Acetylation; KSRP (KHSRP) binds and destabilizes mRNA; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Cyclin A:Cdk2-associated events at S phase entry; CTLA4 inhibitory signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "179" "0" "1.041" "0.829" "0.956" "0.923" "0.852" "0.831" "1.059" "0.910" "1.006" "31.4" "32.6" "26.0" "30.0" "29.0" "26.7" "26.1" "33.2" "28.5" "31.6" "" "" "" "" "" "" "" "" "" "" "31.4" "27.6" "16.4" "21.9" "23.7" "20.7" "20.1" "28.5" "22.3" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "6.522" "10" "3" "3" "3" "262" "31.3" "11.27" "8.04" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.244" "1.158" "0.850" "1.368" "1.108" "1.315" "1.175" "1.500" "1.429" "52.1" "64.9" "60.4" "44.3" "71.4" "57.8" "68.6" "61.3" "78.2" "74.5" "" "" "" "" "" "" "" "" "" "" "52.1" "54.9" "38.2" "32.3" "58.5" "44.9" "52.8" "52.7" "61.1" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "6.520" "9" "2" "2" "2" "287" "32.0" "4.81" "6.32" "2" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "0.846" "0.648" "1.320" "1.057" "0.690" "1.120" "0.928" "0.720" "0.913" "51.8" "43.8" "33.6" "68.4" "54.7" "35.7" "58.0" "48.1" "37.3" "47.3" "" "" "" "" "" "" "" "" "" "" "51.8" "37.1" "21.2" "49.9" "44.8" "27.7" "44.7" "41.3" "29.1" "42.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "6.519" "13" "2" "4" "2" "126" "13.8" "6.95" "13.58" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "0.968" "0.972" "0.933" "0.995" "1.022" "1.154" "0.969" "1.006" "0.850" "393.6" "381.0" "382.5" "367.3" "391.6" "402.1" "454.2" "381.5" "395.9" "334.6" "" "" "" "" "" "" "" "" "" "" "393.6" "322.4" "241.9" "267.8" "320.8" "312.3" "350.1" "328.0" "309.0" "300.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8398668130488909755" "False" "High" "IsMasterProtein" "Q9BXL7" "Caspase recruitment domain-containing protein 11 OS=Homo sapiens OX=9606 GN=CARD11 PE=1 SV=3" "0.000" "False" "6.519" "2" "2" "3" "2" "1154" "133.2" "6.09" "5.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00619" "84433" "ENSG00000198286" "CARD11" "A4D1Z7; hsa:84433; Q2NKN7; Q548H3; Q9BXL7" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "8" "0" "1.010" "1.049" "1.065" "1.010" "1.020" "0.980" "0.969" "0.892" "1.127" "69.0" "69.7" "72.4" "73.5" "69.7" "70.4" "67.6" "66.9" "61.6" "77.8" "" "" "" "" "" "" "" "" "" "" "69.0" "59.0" "45.8" "53.6" "57.1" "54.7" "52.1" "57.5" "48.1" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "6.513" "9" "2" "3" "2" "276" "31.6" "5.59" "5.83" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "6.505" "5" "2" "2" "2" "445" "50.4" "8.27" "6.33" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Lipid metabolism pathway" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.063" "0.952" "0.860" "1.089" "0.991" "1.034" "1.042" "0.903" "0.952" "195.8" "208.2" "186.3" "168.4" "213.3" "194.1" "202.5" "204.1" "176.8" "186.4" "" "" "" "" "" "" "" "" "" "" "195.8" "176.1" "117.8" "122.8" "174.7" "150.7" "156.1" "175.5" "138.0" "167.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3239366280692976916" "False" "High" "IsMasterProtein" "O14920" "Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1" "0.000" "False" "6.503" "2" "2" "2" "1" "756" "86.5" "5.78" "5.90" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "3551" "ENSG00000104365" "IKBKB" "B4DZ30; B4E0U4; hsa:3551; O14920; O75327" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Polycystic kidney disease pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling" "91" "0" "0.919" "0.708" "0.808" "0.774" "0.734" "0.846" "0.907" "0.556" "0.745" "28.5" "26.2" "20.2" "23.0" "22.0" "20.9" "24.1" "25.8" "15.8" "21.2" "" "" "" "" "" "" "" "" "" "" "28.5" "22.2" "12.7" "16.8" "18.1" "16.2" "18.6" "22.2" "12.4" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "6.501" "9" "3" "3" "3" "251" "28.0" "6.71" "8.79" "3" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "0.991" "1.102" "1.207" "0.986" "1.093" "0.924" "1.005" "1.382" "1.240" "64.4" "63.8" "71.0" "77.7" "63.5" "70.4" "59.5" "64.7" "88.9" "79.8" "" "" "" "" "" "" "" "" "" "" "64.4" "54.0" "44.9" "56.7" "52.0" "54.6" "45.9" "55.6" "69.4" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6302302728029836571" "False" "High" "IsMasterProtein" "Q13489" "Baculoviral IAP repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=BIRC3 PE=1 SV=2" "0.000" "False" "6.499" "4" "2" "2" "2" "604" "68.3" "6.04" "6.93" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "330" "ENSG00000023445" "BIRC3" "hsa:330; Q13489; Q16628; Q9HC27; Q9UP46" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "22" "0" "1.112" "0.771" "0.966" "0.966" "1.012" "0.977" "1.049" "1.004" "1.053" "25.6" "28.4" "19.7" "24.7" "24.7" "25.9" "25.0" "26.8" "25.7" "26.9" "" "" "" "" "" "" "" "" "" "" "25.6" "24.1" "12.5" "18.0" "20.2" "20.1" "19.3" "23.1" "20.1" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023888813436623976" "False" "High" "IsMasterProtein" "O94760" "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens OX=9606 GN=DDAH1 PE=1 SV=3" "0.000" "False" "6.499" "6" "2" "2" "2" "285" "31.1" "5.81" "6.22" "2" "other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf19420" "23576" "ENSG00000153904" "DDAH1" "hsa:23576; O94760; Q5HYC8; Q86XK5" "Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis" "eNOS activation" "3" "0" "0.994" "1.212" "1.338" "1.143" "1.246" "1.038" "1.181" "1.106" "1.130" "149.7" "148.8" "181.5" "200.4" "171.0" "186.6" "155.4" "176.8" "165.6" "169.2" "" "" "" "" "" "" "" "" "" "" "149.7" "125.9" "114.8" "146.1" "140.1" "144.9" "119.8" "152.0" "129.3" "152.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "High" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.000" "False" "6.488" "13" "2" "2" "2" "128" "15.1" "9.98" "6.65" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.923" "0.857" "1.022" "1.006" "0.841" "1.036" "0.979" "0.712" "1.031" "176.6" "162.9" "151.2" "180.5" "177.6" "148.5" "182.8" "172.9" "125.6" "182.1" "" "" "" "" "" "" "" "" "" "" "176.6" "137.8" "95.6" "131.6" "145.5" "115.4" "140.9" "148.6" "98.1" "163.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4597879666501405539" "False" "High" "IsMasterProtein" "Q9NX08" "COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1" "0.000" "False" "6.482" "14" "2" "2" "2" "183" "21.1" "5.43" "5.95" "2" "" "cytosol;nucleus" "" "Pf07258" "54951" "ENSG00000169019" "COMMD8" "hsa:54951; Q8WUR4; Q9HC15; Q9NX08" "" "Neddylation" "1" "0" "0.922" "0.584" "0.993" "1.181" "0.609" "1.007" "1.038" "0.911" "1.042" "17.6" "16.2" "10.3" "17.4" "20.8" "10.7" "17.7" "18.2" "16.0" "18.3" "" "" "" "" "" "" "" "" "" "" "17.6" "13.7" "6.5" "12.7" "17.0" "8.3" "13.6" "15.7" "12.5" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3526658263404779392" "False" "High" "IsMasterProtein" "Q9UBI1" "COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1" "0.000" "False" "6.479" "6" "1" "2" "1" "195" "22.1" "5.99" "5.33" "1" "transport" "non-structural extracellular;nucleus;other cell component" "" "Pf07258" "23412" "ENSG00000148444" "COMMD3" "D3DRU7; hsa:23412; Q5T8Y9; Q9UBI1" "" "Neutrophil degranulation; Neddylation" "2" "0" "0.755" "1.020" "0.931" "1.056" "1.069" "0.979" "1.062" "0.948" "1.168" "81.0" "61.2" "82.7" "75.4" "85.5" "86.6" "79.3" "86.0" "76.8" "94.7" "" "" "" "" "" "" "" "" "" "" "81.0" "51.7" "52.3" "55.0" "70.1" "67.3" "61.1" "74.0" "60.0" "85.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.000" "False" "6.471" "1" "2" "2" "2" "2036" "210.9" "7.87" "6.32" "2" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "6.467" "26" "2" "2" "2" "76" "8.8" "5.48" "6.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "High" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.000" "False" "6.467" "2" "2" "2" "2" "1083" "122.1" "8.69" "6.13" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "6.461" "4" "2" "2" "2" "702" "78.2" "6.62" "2.66" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "1.006" "1.167" "1.047" "0.706" "1.289" "0.963" "0.926" "1.306" "1.322" "18.0" "18.1" "21.0" "18.9" "12.7" "23.2" "17.4" "16.7" "23.6" "23.8" "" "" "" "" "" "" "" "" "" "" "18.0" "15.4" "13.3" "13.8" "10.4" "18.1" "13.4" "14.4" "18.4" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "6.451" "9" "2" "2" "2" "282" "31.5" "5.52" "4.35" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "0.981" "1.164" "1.187" "1.018" "1.033" "1.022" "0.966" "1.089" "1.085" "96.0" "94.2" "111.8" "114.0" "97.8" "99.2" "98.2" "92.8" "104.6" "104.2" "" "" "" "" "" "" "" "" "" "" "96.0" "79.7" "70.7" "83.1" "80.1" "77.0" "75.7" "79.8" "81.6" "93.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.000" "False" "6.448" "5" "1" "1" "1" "305" "34.2" "11.84" "4.07" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "mRNA processing" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3369989001081277177" "False" "High" "IsMasterProtein" "Q96CN9" "GRIP and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GCC1 PE=1 SV=1" "0.000" "False" "6.446" "2" "2" "2" "2" "775" "87.8" "5.45" "6.21" "2" "" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01465" "79571" "ENSG00000179562" "GCC1" "hsa:79571; Q96CN9; Q9H6N7" "Nuclear receptors meta-pathway" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.039" "1.151" "1.251" "0.983" "1.128" "1.159" "1.199" "1.103" "0.875" "62.6" "65.0" "72.0" "78.3" "61.5" "70.6" "72.5" "75.0" "69.0" "54.7" "" "" "" "" "" "" "" "" "" "" "62.6" "55.0" "45.5" "57.1" "50.4" "54.8" "55.9" "64.5" "53.9" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547321454778217727" "False" "High" "IsMasterProtein" "Q6PID6" "Tetratricopeptide repeat protein 33 OS=Homo sapiens OX=9606 GN=TTC33 PE=1 SV=2" "0.000" "False" "6.436" "4" "1" "2" "1" "262" "29.4" "5.44" "7.60" "1" "" "" "" "" "23548" "ENSG00000113638" "TTC33" "B2R6G0; hsa:23548; O95105; Q6PID6" "" "" "0" "0" "1.100" "0.924" "0.932" "0.959" "1.001" "1.002" "0.983" "0.952" "1.048" "203.5" "223.9" "188.1" "189.6" "195.3" "203.7" "203.8" "200.1" "193.8" "213.3" "" "" "" "" "" "" "" "" "" "" "203.5" "189.4" "118.9" "138.3" "160.0" "158.2" "157.1" "172.1" "151.2" "191.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-986396495116814729" "False" "High" "IsMasterProtein" "Q8IZ69" "tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2" "0.000" "False" "6.436" "3" "2" "3" "2" "625" "68.7" "7.94" "7.84" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf05958" "27037" "ENSG00000099899" "TRMT2A" "D3DX25; hsa:27037; Q32P57; Q8IZ69; Q96ME6; Q9H732" "22q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "6.422" "4" "1" "1" "1" "464" "51.6" "6.48" "3.93" "1" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Alanine and aspartate metabolism" "Urea cycle" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1360420814074918380" "False" "High" "IsMasterProtein" "Q5T653" "Large ribosomal subunit protein uL2m OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "0.000" "False" "6.416" "6" "2" "3" "2" "305" "33.3" "11.30" "10.10" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.191" "1.028" "1.129" "1.049" "1.132" "1.037" "0.940" "1.128" "1.059" "261.1" "311.0" "268.4" "294.7" "273.7" "295.5" "270.7" "245.3" "294.4" "276.5" "" "" "" "" "" "" "" "" "" "" "261.1" "263.1" "169.7" "214.9" "224.3" "229.5" "208.6" "210.9" "229.8" "248.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.000" "False" "6.414" "5" "3" "3" "3" "496" "55.8" "7.21" "5.03" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "" "Neutrophil degranulation; Intrinsic Pathway of Fibrin Clot Formation" "2" "0" "0.974" "1.130" "1.003" "1.114" "1.069" "1.046" "1.002" "1.079" "1.107" "132.5" "129.0" "149.6" "132.8" "147.6" "141.6" "138.6" "132.7" "142.9" "146.6" "" "" "" "" "" "" "" "" "" "" "132.5" "109.2" "94.6" "96.9" "120.9" "110.0" "106.8" "114.1" "111.6" "131.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "6.406" "4" "1" "1" "1" "298" "33.0" "9.22" "4.55" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Electron transport chain: OXPHOS system in mitochondria" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.860" "0.864" "1.050" "0.937" "0.844" "0.911" "1.040" "0.930" "0.952" "122.1" "105.0" "105.5" "128.3" "114.4" "103.0" "111.2" "127.0" "113.5" "116.3" "" "" "" "" "" "" "" "" "" "" "122.1" "88.8" "66.7" "93.5" "93.7" "80.0" "85.7" "109.2" "88.6" "104.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6044339121918528105" "False" "High" "IsMasterProtein" "O75676" "Ribosomal protein S6 kinase alpha-4 OS=Homo sapiens OX=9606 GN=RPS6KA4 PE=1 SV=1" "0.000" "False" "6.403" "3" "2" "2" "2" "772" "85.6" "8.28" "6.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "8986" "ENSG00000162302" "RPS6KA4" "A8K7Z8; hsa:8986; O75585; O75676; Q53ES8" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Recycling pathway of L1" "7" "0" "1.040" "0.831" "1.150" "1.032" "0.845" "0.987" "0.978" "0.869" "0.970" "193.2" "201.0" "160.6" "222.1" "199.3" "163.2" "190.7" "188.9" "167.9" "187.4" "" "" "" "" "" "" "" "" "" "" "193.2" "170.1" "101.6" "161.9" "163.3" "126.7" "147.0" "162.4" "131.1" "168.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "6.387" "10" "3" "3" "3" "231" "25.7" "6.02" "8.61" "3" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "1.042" "1.019" "1.072" "1.089" "0.891" "1.432" "1.471" "0.979" "1.327" "35.5" "37.0" "36.1" "38.0" "38.6" "31.6" "50.8" "52.1" "34.7" "47.0" "" "" "" "" "" "" "" "" "" "" "35.5" "31.3" "22.8" "27.7" "31.6" "24.5" "39.1" "44.8" "27.1" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530400762788936201" "False" "High" "IsMasterProtein" "O43299" "AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2" "0.000" "False" "6.384" "3" "2" "2" "2" "807" "88.5" "7.01" "6.47" "2" "DNA metabolism;stress response;transport" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14764" "9907" "ENSG00000242802" "AP5Z1" "hsa:9907; O43299; Q8N3X2; Q96H80" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "6.378" "9" "1" "1" "1" "139" "15.9" "6.16" "4.48" "1" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "" "Nuclear Receptor transcription pathway" "1" "0" "1.132" "0.983" "1.248" "1.019" "0.902" "1.184" "1.064" "1.048" "1.160" "77.4" "87.7" "76.1" "96.6" "78.9" "69.8" "91.7" "82.4" "81.2" "89.8" "" "" "" "" "" "" "" "" "" "" "77.4" "74.2" "48.1" "70.5" "64.6" "54.2" "70.7" "70.8" "63.3" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "6.376" "2" "2" "2" "2" "911" "99.9" "7.55" "3.26" "2" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "Envelope proteins and their potential roles in EDMD physiopathology" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; RND2 GTPase cycle; RHOG GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "1.001" "2.014" "1.170" "1.008" "2.227" "1.103" "0.984" "2.297" "1.394" "92.1" "92.3" "185.5" "107.8" "92.8" "205.2" "101.6" "90.6" "211.6" "128.4" "" "" "" "" "" "" "" "" "" "" "92.1" "78.1" "117.3" "78.6" "76.1" "159.4" "78.3" "77.9" "165.2" "115.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.000" "False" "6.358" "7" "2" "2" "2" "246" "28.4" "8.62" "6.21" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.999" "0.848" "1.013" "0.921" "0.854" "1.072" "1.008" "0.871" "0.852" "107.7" "107.6" "91.3" "109.1" "99.2" "91.9" "115.5" "108.5" "93.8" "91.7" "" "" "" "" "" "" "" "" "" "" "107.7" "91.0" "57.8" "79.5" "81.3" "71.4" "89.0" "93.3" "73.2" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "High" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.000" "False" "6.354" "23" "4" "6" "4" "153" "17.6" "9.35" "10.48" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Hedgehog signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "5" "0" "1.159" "1.167" "1.165" "1.217" "1.124" "1.110" "1.178" "1.273" "1.143" "321.4" "372.3" "375.0" "374.5" "391.0" "361.2" "356.8" "378.6" "409.1" "367.2" "" "" "" "" "" "" "" "" "" "" "321.4" "315.0" "237.1" "273.1" "320.4" "280.5" "275.1" "325.5" "319.3" "330.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7374659774527651574" "False" "High" "IsMasterProtein" "Q5T5P2" "Sickle tail protein homolog OS=Homo sapiens OX=9606 GN=KIAA1217 PE=1 SV=2" "0.000" "False" "6.350" "1" "2" "2" "2" "1943" "214.0" "7.06" "6.05" "2" "developmental processes" "cytoskeleton;other cell component" "" "Pf03915" "56243" "ENSG00000120549" "KIAA1217" "A5LHW9; A6NLF3; A6PVQ5; A6PVQ6; A6PVQ7; B9EGK4; hsa:56243; Q4KMG4; Q5T5P2; Q5T5P3; Q5T7H3; Q6MZZ6; Q6ZUI4; Q8WV45; Q9NSR2; Q9ULK3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "6.348" "2" "1" "2" "1" "482" "54.1" "5.55" "6.92" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "0.907" "1.086" "0.854" "0.972" "1.137" "1.120" "0.905" "0.951" "0.923" "112.5" "102.1" "122.2" "96.1" "109.3" "127.9" "126.0" "101.9" "107.0" "103.9" "" "" "" "" "" "" "" "" "" "" "112.5" "86.4" "77.3" "70.1" "89.6" "99.3" "97.2" "87.6" "83.5" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5377293189636928692" "False" "High" "IsMasterProtein" "Q7Z7L8" "Uncharacterized protein C11orf96 OS=Homo sapiens OX=9606 GN=C11orf96 PE=1 SV=3" "0.000" "False" "6.335" "8" "2" "2" "2" "435" "46.1" "9.99" "4.65" "2" "" "" "" "Pf15766" "387763" "" "C11orf96" "Q7Z7L8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.000" "False" "6.331" "3" "2" "2" "2" "520" "58.9" "8.18" "7.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "" "Ub-specific processing proteases" "1" "0" "1.033" "0.987" "1.148" "1.122" "0.970" "1.217" "1.184" "1.032" "1.126" "128.8" "133.0" "127.1" "147.8" "144.5" "125.0" "156.8" "152.5" "132.9" "145.0" "" "" "" "" "" "" "" "" "" "" "128.8" "112.5" "80.4" "107.8" "118.4" "97.1" "120.9" "131.1" "103.7" "130.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4054335882506265826" "False" "High" "IsMasterProtein" "Q8TE73" "Dynein axonemal heavy chain 5 OS=Homo sapiens OX=9606 GN=DNAH5 PE=1 SV=3" "0.000" "False" "6.328" "0" "2" "5" "1" "4624" "528.7" "6.10" "12.69" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "1767" "ENSG00000039139" "DNAH5" "hsa:1767; Q8TE73; Q92860; Q96L74; Q9H5S7; Q9HCG9" "" "" "0" "0" "1.133" "0.986" "1.025" "1.154" "1.014" "1.155" "1.157" "1.082" "1.071" "123.0" "139.3" "121.3" "126.1" "142.0" "124.7" "142.1" "142.3" "133.1" "131.8" "" "" "" "" "" "" "" "" "" "" "123.0" "117.9" "76.7" "91.9" "116.3" "96.9" "109.6" "122.3" "103.9" "118.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "6.326" "15" "3" "3" "3" "176" "20.7" "6.34" "9.31" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "1.124" "1.106" "1.416" "1.238" "1.363" "1.234" "1.165" "1.251" "1.668" "50.7" "57.0" "56.1" "71.8" "62.8" "69.1" "62.6" "59.1" "63.4" "84.6" "" "" "" "" "" "" "" "" "" "" "50.7" "48.2" "35.4" "52.4" "51.5" "53.7" "48.2" "50.8" "49.5" "76.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5901814721160308162" "False" "High" "IsMasterProtein" "Q9UBS0" "Ribosomal protein S6 kinase beta-2 OS=Homo sapiens OX=9606 GN=RPS6KB2 PE=1 SV=2" "0.000" "False" "6.324" "5" "2" "3" "2" "482" "53.4" "7.34" "8.63" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6199" "ENSG00000175634" "RPS6KB2" "B2RMZ9; B4DML8; hsa:6199; O94809; Q9UBS0; Q9UEC1" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Pleural mesothelioma; Acute myeloid leukemia; ErbB signaling pathway" "AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer" "20" "0" "0.981" "0.773" "0.968" "1.107" "0.929" "1.031" "1.044" "0.951" "1.128" "67.7" "66.5" "52.3" "65.6" "75.0" "62.9" "69.8" "70.7" "64.4" "76.4" "" "" "" "" "" "" "" "" "" "" "67.7" "56.2" "33.1" "47.8" "61.4" "48.8" "53.8" "60.8" "50.3" "68.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "6.307" "3" "2" "2" "2" "722" "78.9" "6.38" "6.29" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "6.306" "6" "2" "3" "1" "271" "29.2" "8.37" "8.31" "2" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "NGF-stimulated transcription; CREB phosphorylation" "9" "0" "1.070" "0.918" "1.123" "1.221" "1.062" "1.155" "1.206" "1.241" "1.174" "73.6" "78.7" "67.6" "82.7" "89.8" "78.1" "85.0" "88.8" "91.3" "86.4" "" "" "" "" "" "" "" "" "" "" "73.6" "66.6" "42.7" "60.3" "73.6" "60.7" "65.5" "76.3" "71.3" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "6.302" "4" "1" "2" "1" "275" "30.3" "8.22" "7.25" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; Neddylation; DNA Damage Recognition in GG-NER" "5" "0" "1.072" "1.043" "0.839" "0.995" "0.923" "1.031" "0.955" "0.885" "1.077" "90.9" "97.4" "94.8" "76.3" "90.5" "83.9" "93.7" "86.8" "80.5" "98.0" "" "" "" "" "" "" "" "" "" "" "90.9" "82.4" "60.0" "55.6" "74.1" "65.2" "72.3" "74.6" "62.8" "88.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-727224885467951098" "False" "High" "IsMasterProtein" "O75925" "E3 SUMO-protein ligase PIAS1 OS=Homo sapiens OX=9606 GN=PIAS1 PE=1 SV=2" "0.000" "False" "6.294" "2" "1" "1" "1" "651" "71.8" "7.30" "3.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "8554" "ENSG00000033800" "PIAS1" "B2RB67; B3KSY9; C5J4B4; hsa:8554; O75925; Q147X4; Q99751; Q9UN02" "Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways" "SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER" "14" "0" "1.107" "0.903" "1.208" "1.067" "0.846" "0.940" "0.926" "0.872" "0.869" "75.0" "83.0" "67.7" "90.6" "80.0" "63.5" "70.5" "69.4" "65.4" "65.1" "" "" "" "" "" "" "" "" "" "" "75.0" "70.2" "42.8" "66.1" "65.6" "49.3" "54.3" "59.7" "51.0" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.000" "False" "6.291" "15" "3" "3" "3" "175" "20.3" "8.82" "8.33" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "" "Complex I biogenesis" "1" "0" "0.847" "0.944" "1.042" "0.985" "0.837" "1.009" "1.031" "0.798" "0.799" "45.6" "38.6" "43.0" "47.4" "44.9" "38.1" "46.0" "47.0" "36.4" "36.4" "" "" "" "" "" "" "" "" "" "" "45.6" "32.7" "27.2" "34.6" "36.7" "29.6" "35.4" "40.4" "28.4" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "6.289" "9" "3" "3" "3" "452" "50.7" "6.81" "7.77" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "6.278" "5" "2" "2" "2" "349" "40.2" "5.20" "6.52" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "1.020" "0.887" "1.006" "0.956" "0.799" "0.844" "0.951" "0.952" "0.902" "97.3" "99.2" "86.2" "97.9" "93.0" "77.7" "82.1" "92.5" "92.6" "87.7" "" "" "" "" "" "" "" "" "" "" "97.3" "83.9" "54.5" "71.4" "76.2" "60.4" "63.3" "79.5" "72.3" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.000" "False" "6.271" "5" "1" "2" "1" "240" "27.9" "8.81" "7.83" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "1.043" "0.943" "1.087" "1.220" "0.941" "1.064" "1.142" "0.881" "1.192" "90.9" "94.8" "85.7" "98.8" "110.9" "85.5" "96.7" "103.8" "80.1" "108.3" "" "" "" "" "" "" "" "" "" "" "90.9" "80.2" "54.2" "72.0" "90.9" "66.4" "74.5" "89.3" "62.5" "97.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660217191297362812" "False" "High" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "0.000" "False" "6.269" "5" "2" "2" "2" "453" "48.4" "8.63" "6.31" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Mitochondrial protein degradation; Respiratory electron transport" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "6.246" "10" "1" "1" "1" "275" "29.7" "6.80" "4.84" "1" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "3" "0" "1.141" "1.054" "1.405" "1.045" "2.212" "2.122" "1.075" "1.868" "0.962" "9.4" "10.7" "9.9" "13.2" "9.8" "20.8" "20.0" "10.1" "17.6" "9.0" "" "" "" "" "" "" "" "" "" "" "9.4" "9.1" "6.3" "9.6" "8.1" "16.2" "15.4" "8.7" "13.7" "8.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "High" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.000" "False" "6.236" "2" "2" "2" "1" "879" "97.3" "5.99" "6.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "" "MASTL Facilitates Mitotic Progression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-150019997035989311" "False" "High" "IsMasterProtein" "Q96JK2" "DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2" "0.000" "False" "6.213" "1" "1" "1" "1" "942" "103.9" "5.76" "4.06" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "8816" "ENSG00000139990" "DCAF5" "B2RN31; G3V4J7; hsa:8816; O60559; Q8N3V3; Q8N3V5; Q96JK2" "" "Neddylation" "1" "0" "1.057" "0.788" "0.982" "1.150" "0.666" "1.147" "0.989" "0.649" "0.845" "69.7" "73.6" "54.9" "68.4" "80.1" "46.4" "79.9" "68.9" "45.2" "58.8" "" "" "" "" "" "" "" "" "" "" "69.7" "62.3" "34.7" "49.9" "65.6" "36.0" "61.6" "59.2" "35.3" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "6.213" "10" "2" "2" "2" "291" "33.1" "7.25" "6.07" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "0.964" "1.007" "1.406" "1.401" "1.112" "1.175" "1.458" "0.965" "1.065" "22.5" "21.7" "22.7" "31.7" "31.6" "25.0" "26.5" "32.8" "21.7" "24.0" "" "" "" "" "" "" "" "" "" "" "22.5" "18.4" "14.3" "23.1" "25.9" "19.4" "20.4" "28.2" "17.0" "21.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "6.212" "5" "2" "2" "2" "540" "61.2" "7.09" "6.18" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "13" "0" "1.218" "0.747" "0.838" "0.853" "0.803" "0.666" "0.851" "0.871" "0.960" "51.5" "62.7" "38.5" "43.1" "43.9" "41.3" "34.3" "43.8" "44.8" "49.4" "" "" "" "" "" "" "" "" "" "" "51.5" "53.0" "24.3" "31.4" "35.9" "32.1" "26.4" "37.6" "35.0" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8017071171928965883" "False" "High" "IsMasterProtein" "Q96C12" "Armadillo repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=ARMC5 PE=1 SV=2" "0.000" "False" "6.201" "3" "3" "3" "3" "935" "97.6" "7.11" "7.98" "3" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "" "" "79798" "ENSG00000140691" "ARMC5" "hsa:79798; Q86WM9; Q96C12; Q9H7P8; Q9H925" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8632982163775733346" "False" "High" "IsMasterProtein" "A6NK58" "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial OS=Homo sapiens OX=9606 GN=LIPT2 PE=1 SV=1" "0.000" "False" "6.201" "10" "2" "2" "2" "231" "25.2" "8.27" "6.54" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "" "387787" "ENSG00000175536" "LIPT2" "A6NK58; hsa:387787" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "6.193" "3" "2" "2" "2" "707" "78.7" "9.01" "5.07" "2" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.099" "1.074" "0.934" "1.054" "1.270" "1.002" "1.074" "1.050" "1.187" "63.2" "69.5" "67.9" "59.1" "66.6" "80.3" "63.4" "67.9" "66.4" "75.0" "" "" "" "" "" "" "" "" "" "" "63.2" "58.8" "43.0" "43.1" "54.6" "62.4" "48.8" "58.4" "51.8" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "6.193" "5" "2" "4" "2" "309" "34.4" "7.33" "10.61" "2" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "1" "0" "1.074" "1.263" "1.052" "1.092" "1.181" "1.104" "1.089" "1.241" "1.122" "332.3" "356.8" "419.7" "349.6" "362.9" "392.6" "366.9" "362.1" "412.5" "372.8" "" "" "" "" "" "" "" "" "" "" "332.3" "301.9" "265.4" "254.9" "297.3" "304.9" "282.8" "311.3" "322.0" "335.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186240485352530352" "False" "High" "IsMasterProtein" "Q96SI1" "BTB/POZ domain-containing protein KCTD15 OS=Homo sapiens OX=9606 GN=KCTD15 PE=1 SV=1" "0.000" "False" "6.185" "6" "2" "2" "2" "283" "31.9" "7.44" "7.71" "2" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf02214, Pf20871" "79047" "ENSG00000153885" "KCTD15" "A8K600; hsa:79047; Q96SI1; Q9BVI6" "" "Negative regulation of activity of TFAP2 (AP-2) family transcription factors" "1" "0" "1.110" "1.064" "1.115" "1.112" "0.988" "1.043" "1.011" "0.923" "0.973" "91.2" "101.3" "97.1" "101.8" "101.5" "90.1" "95.2" "92.3" "84.2" "88.8" "" "" "" "" "" "" "" "" "" "" "91.2" "85.7" "61.4" "74.2" "83.1" "70.0" "73.4" "79.3" "65.7" "79.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "6.180" "3" "2" "2" "2" "791" "85.8" "6.32" "6.58" "2" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "11" "0" "0.895" "0.933" "0.963" "0.995" "1.009" "0.898" "0.969" "0.959" "1.152" "124.5" "111.4" "116.2" "119.9" "123.9" "125.6" "111.7" "120.6" "119.4" "143.4" "" "" "" "" "" "" "" "" "" "" "124.5" "94.3" "73.4" "87.4" "101.5" "97.6" "86.1" "103.7" "93.2" "129.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "6.162" "3" "2" "2" "2" "1023" "112.6" "8.40" "5.05" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "1.001" "0.566" "0.919" "0.947" "0.577" "1.241" "1.012" "0.591" "0.923" "36.0" "36.0" "20.4" "33.1" "34.1" "20.8" "44.7" "36.4" "21.3" "33.2" "" "" "" "" "" "" "" "" "" "" "36.0" "30.5" "12.9" "24.1" "27.9" "16.1" "34.4" "31.3" "16.6" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329902597412157938" "False" "High" "IsMasterProtein" "Q15048" "Leucine-rich repeat-containing protein 14 OS=Homo sapiens OX=9606 GN=LRRC14 PE=1 SV=1" "0.000" "False" "6.160" "3" "2" "2" "2" "493" "54.5" "6.90" "5.29" "2" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf13516" "9684" "ENSG00000160959" "LRRC14" "A8K0A8; D3DWM8; hsa:9684; Q15048" "" "Regulation of NF-kappa B signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8100035487755028303" "False" "High" "IsMasterProtein" "P51957" "Serine/threonine-protein kinase Nek4 OS=Homo sapiens OX=9606 GN=NEK4 PE=1 SV=2" "0.000" "False" "6.156" "3" "2" "2" "2" "841" "94.5" "7.90" "5.29" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069" "6787" "ENSG00000114904" "NEK4" "A5YM70; B2R633; B7Z200; P51957; Q6P576" "" "" "0" "0" "1.094" "0.927" "1.121" "1.097" "0.984" "1.145" "1.141" "0.921" "0.988" "146.6" "160.3" "135.9" "164.4" "160.7" "144.2" "167.8" "167.2" "135.0" "144.8" "" "" "" "" "" "" "" "" "" "" "146.6" "135.6" "85.9" "119.9" "131.7" "112.0" "129.3" "143.7" "105.4" "130.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.000" "False" "6.154" "6" "2" "2" "1" "361" "39.8" "5.45" "5.33" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "3" "0" "0.734" "1.047" "1.015" "0.814" "0.865" "1.143" "0.927" "0.837" "0.738" "31.8" "23.3" "33.3" "32.3" "25.9" "27.5" "36.3" "29.5" "26.6" "23.5" "" "" "" "" "" "" "" "" "" "" "31.8" "19.7" "21.1" "23.5" "21.2" "21.4" "28.0" "25.3" "20.8" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7231922059350436850" "False" "High" "IsMasterProtein" "Q9P1W9" "Serine/threonine-protein kinase pim-2 OS=Homo sapiens OX=9606 GN=PIM2 PE=1 SV=1" "0.000" "False" "6.138" "5" "2" "3" "2" "311" "34.2" "5.92" "8.47" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "11040" "ENSG00000102096; ENSG00000292210" "PIM2" "A8K4G6; hsa:11040; Q99739; Q9P1W9" "Imatinib and chronic myeloid leukemia; Translation inhibitors in chronically activated PDGFRA cells; Acute myeloid leukemia" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "6.133" "4" "2" "2" "2" "559" "62.0" "8.59" "7.01" "2" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2343192111564668879" "False" "High" "IsMasterProtein" "Q96NW4" "Ankyrin repeat domain-containing protein 27 OS=Homo sapiens OX=9606 GN=ANKRD27 PE=1 SV=2" "0.000" "False" "6.131" "1" "1" "1" "1" "1050" "116.9" "6.87" "3.81" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02204, Pf12796" "84079" "ENSG00000105186" "ANKRD27" "hsa:84079; Q71MF5; Q86UC3; Q8ND80; Q96NW4; Q9H0I4" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1530625692360911706" "False" "High" "IsMasterProtein" "Q8IWB7" "WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1" "0.000" "False" "6.126" "3" "1" "1" "1" "410" "46.3" "7.33" "4.35" "1" "other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf01363" "57590" "ENSG00000085449" "WDFY1" "hsa:57590; Q53S17; Q8IWB7; Q9H9D5; Q9P2B3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "6.126" "5" "1" "2" "1" "167" "19.4" "7.40" "6.69" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "0.858" "1.074" "0.995" "1.077" "0.999" "0.947" "0.963" "0.965" "0.952" "76.3" "65.4" "81.9" "75.9" "82.1" "76.1" "72.2" "73.4" "73.6" "72.6" "" "" "" "" "" "" "" "" "" "" "76.3" "55.3" "51.8" "55.3" "67.3" "59.1" "55.6" "63.1" "57.4" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326437507521645462" "False" "High" "IsMasterProtein" "Q9P2W1" "Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1" "0.000" "False" "6.126" "6" "1" "1" "1" "217" "24.9" "7.81" "4.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07106, Pf18517" "29893" "ENSG00000131470" "PSMC3IP" "C5ILB7; hsa:29893; Q14458; Q8WXG2; Q96HA2; Q9P2W1" "Androgen receptor signaling pathway; Primary ovarian insufficiency" "Meiotic recombination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "6.119" "19" "2" "3" "2" "101" "11.6" "5.52" "9.87" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "PKR-mediated signaling; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of IFNG signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "27" "0" "0.899" "0.992" "0.980" "0.904" "0.984" "1.080" "0.906" "0.994" "0.941" "214.6" "192.9" "212.8" "210.4" "193.9" "211.0" "231.7" "194.5" "213.3" "201.9" "" "" "" "" "" "" "" "" "" "" "214.6" "163.2" "134.6" "153.4" "158.9" "163.9" "178.6" "167.2" "166.5" "181.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "6.108" "5" "2" "2" "1" "291" "32.8" "5.34" "7.11" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "6.106" "7" "2" "2" "2" "281" "31.9" "8.73" "6.55" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "7q11.23 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.086" "1.019" "0.979" "1.122" "1.039" "0.930" "1.089" "1.031" "1.214" "70.3" "76.4" "71.6" "68.9" "78.9" "73.1" "65.4" "76.6" "72.5" "85.4" "" "" "" "" "" "" "" "" "" "" "70.3" "64.6" "45.3" "50.2" "64.6" "56.8" "50.4" "65.9" "56.6" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513337833647549896" "False" "High" "IsMasterProtein" "P11717" "Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3" "0.000" "False" "6.090" "1" "2" "2" "2" "2491" "274.2" "5.94" "4.52" "2" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00040, Pf00878" "3482" "ENSG00000197081" "IGF2R" "hsa:3482; P11717; Q7Z7G9; Q96PT5" "TROP2 regulatory signaling" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "1.067" "0.965" "1.113" "0.929" "0.931" "1.210" "0.939" "1.092" "1.238" "46.8" "49.9" "45.2" "52.1" "43.5" "43.6" "56.6" "43.9" "51.1" "57.9" "" "" "" "" "" "" "" "" "" "" "46.8" "42.2" "28.5" "38.0" "35.6" "33.8" "43.7" "37.8" "39.9" "52.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "6.086" "6" "1" "1" "1" "330" "36.3" "6.79" "5.93" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Neutrophil degranulation; Heme biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "6.080" "4" "3" "3" "3" "665" "73.1" "6.62" "8.83" "3" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "9" "0" "0.920" "1.011" "0.947" "1.111" "1.030" "0.888" "1.028" "1.003" "0.999" "149.5" "137.6" "151.1" "141.6" "166.1" "154.0" "132.8" "153.8" "150.0" "149.4" "" "" "" "" "" "" "" "" "" "" "149.5" "116.4" "95.6" "103.3" "136.1" "119.6" "102.3" "132.2" "117.1" "134.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "6.077" "12" "2" "2" "2" "190" "20.7" "6.32" "6.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.015" "1.040" "0.941" "0.953" "1.094" "1.144" "0.911" "1.085" "1.038" "58.8" "59.7" "61.2" "55.4" "56.1" "64.3" "67.3" "53.6" "63.8" "61.1" "" "" "" "" "" "" "" "" "" "" "58.8" "50.5" "38.7" "40.4" "45.9" "50.0" "51.9" "46.1" "49.8" "54.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6689030380433317187" "False" "High" "IsMasterProtein" "Q01543" "Friend leukemia integration 1 transcription factor OS=Homo sapiens OX=9606 GN=FLI1 PE=1 SV=1" "0.000" "False" "6.058" "4" "2" "2" "2" "452" "51.0" "7.06" "5.38" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2313" "ENSG00000151702" "FLI1" "B2R8H2; B4DFV4; B4DTC6; G3V183; hsa:2313; Q01543; Q14319; Q92480; Q9UE07" "Hematopoietic stem cell differentiation" "Transcriptional regulation of granulopoiesis" "2" "0" "1.159" "0.837" "1.084" "1.029" "1.005" "1.175" "1.043" "0.921" "1.017" "138.6" "160.6" "116.0" "150.2" "142.7" "139.3" "162.8" "144.5" "127.7" "141.0" "" "" "" "" "" "" "" "" "" "" "138.6" "135.9" "73.4" "109.5" "116.9" "108.1" "125.5" "124.2" "99.6" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703387660850171759" "False" "High" "IsMasterProtein" "O95900" "Pseudouridylate synthase TRUB2, mitochondrial OS=Homo sapiens OX=9606 GN=TRUB2 PE=1 SV=1" "0.000" "False" "6.055" "6" "2" "2" "2" "331" "36.7" "8.98" "4.93" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01509" "26995" "ENSG00000167112" "TRUB2" "B7Z7G5; hsa:26995; O95900" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.000" "False" "6.048" "4" "1" "1" "1" "314" "36.0" "4.81" "4.69" "1" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Acute viral myocarditis" "Myogenesis" "2" "0" "1.026" "0.948" "0.807" "0.984" "0.888" "0.930" "0.872" "0.868" "1.044" "69.5" "71.3" "65.8" "56.0" "68.3" "61.7" "64.6" "60.6" "60.3" "72.5" "" "" "" "" "" "" "" "" "" "" "69.5" "60.3" "41.6" "40.9" "56.0" "47.9" "49.8" "52.1" "47.1" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2902136520496705703" "False" "High" "IsMasterProtein" "Q8N3F8" "MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2" "0.000" "False" "6.042" "3" "3" "3" "3" "863" "93.4" "7.25" "7.90" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00307, Pf00412, Pf12130" "85377" "ENSG00000100139" "MICALL1" "hsa:85377; Q5TI16; Q7RTP5; Q8N3F8; Q8N3N8; Q9BVL9; Q9BY92; Q9UH43; Q9UH44; Q9UH45" "" "" "0" "0" "1.036" "0.935" "1.110" "1.144" "0.947" "1.091" "1.037" "1.021" "1.075" "191.3" "198.2" "178.9" "212.3" "218.8" "181.1" "208.7" "198.4" "195.2" "205.6" "" "" "" "" "" "" "" "" "" "" "191.3" "167.7" "113.1" "154.8" "179.2" "140.7" "160.9" "170.6" "152.4" "184.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "6.036" "5" "2" "2" "2" "414" "45.6" "6.16" "5.21" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "2q37 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835472215069796756" "False" "High" "IsMasterProtein" "Q9Y692" "Glucocorticoid modulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=GMEB1 PE=1 SV=2" "0.000" "False" "6.033" "3" "2" "2" "1" "573" "62.6" "4.83" "5.67" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "10691" "ENSG00000162419" "GMEB1" "B1AT48; hsa:10691; Q9NWH1; Q9UKD0; Q9Y692" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.000" "False" "6.031" "3" "2" "2" "2" "587" "64.6" "7.94" "6.28" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "Fluoropyrimidine activity" "" "1" "0" "1.177" "0.727" "1.225" "1.212" "0.840" "0.933" "1.148" "0.815" "1.040" "34.0" "40.0" "24.7" "41.6" "41.2" "28.5" "31.7" "39.0" "27.7" "35.3" "" "" "" "" "" "" "" "" "" "" "34.0" "33.9" "15.6" "30.4" "33.8" "22.2" "24.4" "33.5" "21.6" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "6.026" "5" "2" "2" "2" "421" "46.1" "9.99" "5.82" "2" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.371" "1.290" "1.015" "1.425" "1.467" "1.079" "1.104" "1.337" "1.017" "40.3" "55.2" "52.0" "40.9" "57.4" "59.1" "43.5" "44.5" "53.9" "41.0" "" "" "" "" "" "" "" "" "" "" "40.3" "46.7" "32.9" "29.8" "47.0" "45.9" "33.5" "38.2" "42.0" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "6.026" "6" "2" "2" "2" "447" "51.2" "6.05" "5.13" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "6.024" "3" "3" "4" "2" "931" "98.9" "5.86" "9.62" "3" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1654443810418690353" "False" "High" "IsMasterProtein" "Q9UJU2" "Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1" "0.000" "False" "6.024" "3" "1" "1" "1" "399" "44.2" "7.42" "4.61" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf08347" "51176" "ENSG00000138795" "LEF1" "B4DG38; B7Z8E2; E9PDK3; hsa:51176; Q3ZCU4; Q9HAZ0; Q9UJU2" "Arrhythmogenic right ventricular cardiomyopathy; Endoderm differentiation; Mesodermal commitment pathway; Mesodermal commitment pathway; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Effect of progerin on genes involved in progeria; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Hippo signaling regulation pathways; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Acute myeloid leukemia; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Formation of paraxial mesoderm; Transcriptional Regulation by VENTX; Ca2+ pathway; Transcriptional regulation of granulopoiesis; Somitogenesis; Formation of axial mesoderm; Deactivation of the beta-catenin transactivating complex; Cardiogenesis; Germ layer formation at gastrulation; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Repression of WNT target genes" "41" "0" "1.003" "0.725" "1.087" "1.061" "0.601" "1.010" "0.975" "0.748" "0.924" "117.2" "117.6" "84.9" "127.4" "124.4" "70.5" "118.4" "114.3" "87.7" "108.3" "" "" "" "" "" "" "" "" "" "" "117.2" "99.5" "53.7" "92.9" "101.9" "54.7" "91.3" "98.3" "68.4" "97.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9152525013652249776" "False" "High" "IsMasterProtein" "Q9H999" "Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1" "0.000" "False" "6.023" "5" "2" "2" "1" "370" "41.1" "6.55" "5.85" "2" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf03630" "79646" "ENSG00000120137" "PANK3" "D3DQL1; hsa:79646; Q53FJ9; Q7RTX4; Q9H999" "" "Coenzyme A biosynthesis" "1" "0" "1.122" "0.921" "0.899" "0.986" "0.908" "1.036" "1.114" "0.961" "1.065" "41.2" "46.2" "37.9" "37.0" "40.6" "37.4" "42.7" "45.9" "39.6" "43.8" "" "" "" "" "" "" "" "" "" "" "41.2" "39.1" "24.0" "27.0" "33.3" "29.0" "32.9" "39.4" "30.9" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7252282534917135675" "False" "High" "IsMasterProtein" "Q15542" "Transcription initiation factor TFIID subunit 5 OS=Homo sapiens OX=9606 GN=TAF5 PE=1 SV=3" "0.000" "False" "6.022" "3" "2" "2" "2" "800" "86.8" "5.64" "5.91" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "6877" "ENSG00000148835" "TAF5" "A8K5B4; B2RMR0; B7ZKJ6; hsa:6877; Q15542; Q53EM4; Q5SYD5; Q86UZ7; Q9Y4K5" "Eukaryotic transcription initiation" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "0.855" "0.624" "0.843" "0.986" "1.152" "0.983" "1.004" "0.885" "0.755" "34.6" "29.6" "21.6" "29.1" "34.1" "39.8" "34.0" "34.7" "30.6" "26.1" "" "" "" "" "" "" "" "" "" "" "34.6" "25.0" "13.7" "21.2" "27.9" "30.9" "26.2" "29.8" "23.9" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612567353731900527" "False" "High" "IsMasterProtein" "Q9UM82" "Spermatogenesis-associated protein 2 OS=Homo sapiens OX=9606 GN=SPATA2 PE=1 SV=2" "0.000" "False" "6.020" "3" "2" "2" "2" "520" "58.4" "8.75" "5.36" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf21388" "9825" "ENSG00000158480" "SPATA2" "E1P626; hsa:9825; O94857; Q9UM82" "" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "3" "0" "1.103" "0.903" "1.127" "1.132" "0.884" "1.317" "1.111" "1.047" "1.065" "54.6" "60.3" "49.3" "61.5" "61.8" "48.3" "71.9" "60.7" "57.2" "58.1" "" "" "" "" "" "" "" "" "" "" "54.6" "51.0" "31.2" "44.9" "50.6" "37.5" "55.4" "52.2" "44.6" "52.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "6.018" "4" "2" "2" "2" "520" "59.6" "8.21" "8.30" "2" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "1.070" "0.983" "1.152" "1.151" "0.965" "0.958" "1.024" "0.991" "0.986" "133.0" "142.3" "130.8" "153.3" "153.1" "128.4" "127.5" "136.2" "131.8" "131.2" "" "" "" "" "" "" "" "" "" "" "133.0" "120.4" "82.7" "111.8" "125.5" "99.7" "98.3" "117.1" "102.9" "117.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "6.018" "2" "1" "1" "1" "619" "67.5" "5.21" "4.27" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "2" "0" "1.085" "0.720" "1.044" "0.981" "0.738" "1.031" "1.031" "0.728" "1.030" "57.0" "61.9" "41.0" "59.5" "55.9" "42.1" "58.8" "58.8" "41.5" "58.7" "" "" "" "" "" "" "" "" "" "" "57.0" "52.3" "26.0" "43.4" "45.8" "32.7" "45.3" "50.6" "32.4" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "6.015" "7" "2" "2" "2" "266" "29.8" "6.84" "6.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "6.014" "3" "2" "2" "2" "645" "72.4" "7.61" "6.67" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.027" "1.135" "0.931" "1.039" "1.048" "1.107" "1.010" "1.002" "1.019" "92.9" "95.5" "105.5" "86.5" "96.6" "97.4" "102.8" "93.9" "93.1" "94.7" "" "" "" "" "" "" "" "" "" "" "92.9" "80.8" "66.7" "63.1" "79.1" "75.6" "79.3" "80.7" "72.7" "85.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "6.005" "4" "2" "2" "2" "563" "61.2" "6.48" "6.06" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "6.003" "3" "2" "2" "2" "547" "61.6" "9.26" "4.49" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "6.001" "6" "2" "2" "1" "277" "31.4" "7.30" "5.75" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "Pyrimidine salvage" "4" "0" "1.136" "1.079" "1.275" "1.203" "0.979" "1.203" "1.201" "1.069" "1.222" "83.0" "94.3" "89.6" "105.8" "99.9" "81.3" "99.9" "99.7" "88.7" "101.4" "" "" "" "" "" "" "" "" "" "" "83.0" "79.8" "56.6" "77.2" "81.8" "63.1" "77.0" "85.7" "69.3" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "5.993" "2" "2" "2" "2" "940" "99.0" "9.17" "5.88" "2" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "1.147" "0.982" "1.102" "1.214" "1.148" "1.082" "1.067" "1.030" "1.066" "159.0" "182.4" "156.1" "175.2" "193.0" "182.5" "172.0" "169.7" "163.7" "169.5" "" "" "" "" "" "" "" "" "" "" "159.0" "154.3" "98.7" "127.7" "158.1" "141.8" "132.6" "145.9" "127.8" "152.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "5.991" "1" "1" "1" "1" "1410" "155.2" "7.40" "3.90" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "1.029" "0.689" "1.402" "1.177" "0.666" "1.385" "1.440" "0.497" "1.034" "29.5" "30.3" "20.3" "41.3" "34.7" "19.6" "40.8" "42.4" "14.6" "30.5" "" "" "" "" "" "" "" "" "" "" "29.5" "25.7" "12.8" "30.1" "28.4" "15.2" "31.5" "36.5" "11.4" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "5.990" "2" "2" "2" "2" "1440" "159.4" "6.14" "5.79" "2" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "1.004" "0.742" "0.895" "1.007" "0.945" "0.948" "0.965" "0.694" "0.926" "37.4" "37.5" "27.7" "33.5" "37.7" "35.3" "35.5" "36.1" "26.0" "34.6" "" "" "" "" "" "" "" "" "" "" "37.4" "31.8" "17.5" "24.4" "30.9" "27.4" "27.3" "31.0" "20.3" "31.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "5.984" "11" "2" "3" "2" "178" "19.3" "4.63" "8.65" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "1.135" "1.146" "0.997" "1.074" "1.230" "1.026" "1.042" "1.181" "1.111" "165.3" "187.7" "189.4" "164.9" "177.5" "203.3" "169.5" "172.3" "195.3" "183.6" "" "" "" "" "" "" "" "" "" "" "165.3" "158.8" "119.8" "120.2" "145.4" "157.9" "130.7" "148.2" "152.4" "165.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "5.982" "7" "2" "2" "2" "247" "27.9" "7.74" "7.18" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.958" "0.921" "1.197" "1.246" "0.875" "1.282" "1.031" "0.977" "1.098" "80.0" "76.6" "73.7" "95.8" "99.7" "70.0" "102.6" "82.5" "78.1" "87.9" "" "" "" "" "" "" "" "" "" "" "80.0" "64.8" "46.6" "69.9" "81.7" "54.4" "79.1" "71.0" "61.0" "79.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2572043715436263453" "False" "High" "IsMasterProtein" "Q9H3R5" "Centromere protein H OS=Homo sapiens OX=9606 GN=CENPH PE=1 SV=1" "0.000" "False" "5.970" "7" "1" "1" "1" "247" "28.5" "5.29" "4.36" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "other molecular function" "Pf05837" "64946" "ENSG00000153044" "CENPH" "A8K3Y1; hsa:64946; Q9H3R5" "" "Resolution of Sister Chromatid Cohesion; Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.385" "1.321" "1.470" "1.200" "1.266" "2.028" "1.481" "1.339" "1.592" "24.5" "34.0" "32.4" "36.0" "29.4" "31.0" "49.7" "36.3" "32.8" "39.0" "" "" "" "" "" "" "" "" "" "" "24.5" "28.7" "20.5" "26.3" "24.1" "24.1" "38.3" "31.2" "25.6" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "5.961" "2" "1" "1" "1" "627" "70.2" "6.61" "3.75" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "" "Neddylation" "1" "0" "1.093" "0.820" "0.992" "1.066" "0.802" "1.094" "1.086" "0.930" "1.034" "95.7" "104.6" "78.5" "95.0" "102.0" "76.7" "104.7" "104.0" "89.0" "98.9" "" "" "" "" "" "" "" "" "" "" "95.7" "88.5" "49.6" "69.2" "83.6" "59.6" "80.7" "89.4" "69.5" "88.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "5.957" "4" "2" "2" "2" "592" "67.3" "5.92" "6.07" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "Ras signaling" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "6" "0" "0.829" "0.742" "1.006" "0.706" "1.108" "0.833" "0.974" "0.916" "1.110" "32.8" "27.2" "24.3" "33.0" "23.1" "36.3" "27.3" "31.9" "30.0" "36.4" "" "" "" "" "" "" "" "" "" "" "32.8" "23.0" "15.4" "24.1" "19.0" "28.2" "21.1" "27.4" "23.4" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "5.945" "4" "2" "2" "2" "589" "65.4" "6.80" "5.47" "2" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.000" "False" "5.937" "2" "2" "3" "2" "1298" "146.5" "7.01" "6.46" "2" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "5.933" "5" "2" "2" "2" "500" "55.6" "7.18" "5.95" "2" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "Somitogenesis; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "20" "0" "1.120" "0.994" "1.134" "1.214" "1.056" "1.183" "1.038" "1.200" "1.115" "97.2" "108.8" "96.5" "110.2" "118.0" "102.6" "115.0" "100.8" "116.6" "108.3" "" "" "" "" "" "" "" "" "" "" "97.2" "92.1" "61.0" "80.4" "96.7" "79.7" "88.6" "86.7" "91.0" "97.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "High" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.000" "False" "5.925" "3" "2" "2" "1" "606" "67.5" "9.01" "4.90" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "33" "0" "0.977" "1.065" "1.017" "1.130" "0.974" "0.956" "1.034" "0.903" "1.050" "58.9" "57.5" "62.7" "59.9" "66.5" "57.4" "56.2" "60.9" "53.1" "61.8" "" "" "" "" "" "" "" "" "" "" "58.9" "48.6" "39.6" "43.7" "54.5" "44.5" "43.4" "52.3" "41.5" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "5.917" "4" "2" "2" "2" "521" "56.4" "7.99" "7.12" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "2q37 copy number variation syndrome" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3903200629464870595" "False" "High" "IsMasterProtein" "Q6P6B7" "Ankyrin repeat domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ANKRD16 PE=1 SV=1" "0.000" "False" "5.910" "3" "1" "1" "1" "361" "39.3" "7.25" "4.58" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf12796" "54522" "ENSG00000134461" "ANKRD16" "A6NEF0; F8WEI4; hsa:54522; Q6P6B7; Q9NT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "5.907" "14" "2" "4" "2" "184" "20.1" "4.18" "4.49" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "NF1 copy number variation syndrome" "RMTs methylate histone arginines" "2" "0" "1.166" "1.059" "0.919" "1.186" "1.180" "1.441" "1.001" "1.206" "1.251" "22.4" "26.1" "23.7" "20.6" "26.6" "26.5" "32.3" "22.4" "27.0" "28.1" "" "" "" "" "" "" "" "" "" "" "22.4" "22.1" "15.0" "15.0" "21.8" "20.5" "24.9" "19.3" "21.1" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9042587910182290108" "False" "High" "IsMasterProtein" "Q8IZM8" "Zinc finger protein 654 OS=Homo sapiens OX=9606 GN=ZNF654 PE=1 SV=4" "0.000" "False" "5.907" "1" "1" "1" "1" "1128" "127.8" "5.27" "5.46" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "" "ENSG00000175105" "ZNF654" "A0A1B0GWA0; Q8IZM8; Q9H791; Q9NV14" "" "" "0" "0" "0.814" "0.967" "0.997" "0.965" "0.745" "0.780" "0.823" "0.834" "1.031" "25.2" "20.5" "24.3" "25.1" "24.3" "18.7" "19.6" "20.7" "21.0" "25.9" "" "" "" "" "" "" "" "" "" "" "25.2" "17.3" "15.4" "18.3" "19.9" "14.6" "15.1" "17.8" "16.4" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "5.901" "7" "1" "1" "1" "186" "20.4" "4.94" "3.80" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "" "Phase 0 - rapid depolarisation" "1" "0" "0.923" "1.245" "1.278" "1.070" "1.102" "1.382" "1.265" "1.267" "0.976" "50.5" "46.6" "62.8" "64.5" "54.0" "55.6" "69.7" "63.8" "63.9" "49.3" "" "" "" "" "" "" "" "" "" "" "50.5" "39.4" "39.7" "47.0" "44.2" "43.2" "53.8" "54.9" "49.9" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "High" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.000" "False" "5.899" "3" "2" "3" "2" "607" "68.3" "5.27" "7.91" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "1.158" "0.730" "1.139" "1.040" "0.980" "1.165" "1.171" "0.857" "0.929" "72.7" "84.2" "53.1" "82.8" "75.6" "71.3" "84.7" "85.1" "62.3" "67.6" "" "" "" "" "" "" "" "" "" "" "72.7" "71.3" "33.5" "60.4" "61.9" "55.4" "65.3" "73.2" "48.7" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "5.897" "4" "2" "2" "2" "594" "66.0" "9.19" "7.12" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "0.776" "1.163" "1.250" "1.101" "1.027" "0.889" "0.866" "0.987" "1.002" "44.7" "34.7" "52.0" "55.9" "49.2" "45.9" "39.8" "38.7" "44.1" "44.8" "" "" "" "" "" "" "" "" "" "" "44.7" "29.4" "32.9" "40.7" "40.3" "35.6" "30.6" "33.3" "34.4" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "5.896" "12" "1" "4" "1" "102" "11.8" "4.70" "13.04" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "1.052" "1.131" "0.894" "0.973" "1.135" "1.134" "1.006" "1.202" "1.074" "204.6" "215.1" "231.4" "182.9" "199.0" "232.2" "232.0" "205.8" "245.9" "219.7" "" "" "" "" "" "" "" "" "" "" "204.6" "182.0" "146.3" "133.3" "163.1" "180.4" "178.8" "177.0" "191.9" "197.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.000" "False" "5.892" "9" "2" "2" "2" "204" "23.7" "5.67" "7.26" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.112" "1.014" "1.348" "1.144" "1.052" "1.169" "1.037" "1.104" "0.950" "61.7" "68.6" "62.5" "83.1" "70.5" "64.9" "72.1" "64.0" "68.1" "58.6" "" "" "" "" "" "" "" "" "" "" "61.7" "58.0" "39.5" "60.6" "57.8" "50.4" "55.6" "55.0" "53.2" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "5.892" "2" "2" "2" "2" "875" "98.5" "6.73" "5.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "" "Amino acids regulate mTORC1" "1" "0" "0.957" "0.913" "1.089" "0.953" "0.935" "0.922" "1.060" "0.915" "0.936" "117.5" "112.5" "107.3" "128.1" "112.0" "109.9" "108.4" "124.6" "107.6" "110.1" "" "" "" "" "" "" "" "" "" "" "117.5" "95.2" "67.9" "93.4" "91.7" "85.4" "83.6" "107.1" "84.0" "98.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "5.891" "2" "1" "1" "1" "557" "61.8" "5.97" "4.03" "1" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "0.936" "0.694" "1.110" "0.902" "0.745" "1.039" "1.028" "0.858" "0.994" "57.3" "53.6" "39.7" "63.6" "51.7" "42.7" "59.5" "58.9" "49.2" "57.0" "" "" "" "" "" "" "" "" "" "" "57.3" "45.4" "25.1" "46.4" "42.3" "33.1" "45.9" "50.6" "38.4" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7145553044462341407" "False" "High" "IsMasterProtein" "Q8NI36" "WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1" "0.000" "False" "5.885" "2" "2" "2" "2" "951" "105.3" "7.53" "5.69" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04192, Pf12894" "134430" "" "WDR36" "A2RUS4; hsa:134430; Q68E02; Q8N1Q2; Q8NI36" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7679748802745987777" "False" "High" "IsMasterProtein" "Q9NUL7" "Probable ATP-dependent RNA helicase DDX28 OS=Homo sapiens OX=9606 GN=DDX28 PE=1 SV=2" "0.000" "False" "5.868" "3" "2" "2" "2" "540" "59.5" "10.42" "7.37" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55794" "ENSG00000182810" "DDX28" "hsa:55794; Q9NUL7" "" "" "0" "0" "1.029" "0.948" "1.019" "1.009" "0.869" "0.982" "1.017" "0.990" "1.135" "95.1" "97.9" "90.1" "96.9" "96.0" "82.7" "93.3" "96.7" "94.1" "108.0" "" "" "" "" "" "" "" "" "" "" "95.1" "82.8" "57.0" "70.7" "78.7" "64.2" "72.0" "83.2" "73.5" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "High" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.000" "False" "5.868" "5" "1" "1" "1" "339" "37.8" "6.30" "4.35" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR" "7" "0" "1.290" "1.376" "1.367" "1.474" "1.125" "1.399" "1.170" "1.252" "1.029" "24.7" "31.8" "33.9" "33.7" "36.3" "27.7" "34.5" "28.9" "30.9" "25.4" "" "" "" "" "" "" "" "" "" "" "24.7" "26.9" "21.4" "24.6" "29.8" "21.5" "26.6" "24.8" "24.1" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3011217780081752783" "False" "High" "IsMasterProtein" "O43164" "E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens OX=9606 GN=PJA2 PE=1 SV=4" "0.000" "False" "5.866" "3" "2" "3" "2" "708" "78.2" "4.39" "8.50" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf13639" "9867" "ENSG00000198961" "PJA2" "A8K6U4; D3DSZ5; O43164; Q68D49; Q8N1G5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.928" "0.812" "0.941" "1.126" "0.888" "1.081" "1.037" "0.914" "0.988" "201.7" "187.2" "163.7" "189.8" "227.1" "179.1" "217.9" "209.2" "184.3" "199.2" "" "" "" "" "" "" "" "" "" "" "201.7" "158.4" "103.5" "138.4" "186.1" "139.1" "168.0" "179.9" "143.8" "179.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "5.863" "2" "2" "2" "2" "1339" "151.0" "4.82" "5.93" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "" "Activation of ATR in response to replication stress; Ub-specific processing proteases; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins" "4" "0" "0.989" "0.771" "1.034" "0.996" "0.897" "1.097" "1.083" "0.822" "0.936" "130.7" "129.2" "100.8" "135.2" "130.2" "117.2" "143.4" "141.6" "107.5" "122.3" "" "" "" "" "" "" "" "" "" "" "130.7" "109.3" "63.8" "98.6" "106.7" "91.0" "110.5" "121.7" "83.9" "110.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5402246304287674254" "False" "High" "IsMasterProtein" "Q53R41" "FAST kinase domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD1 PE=1 SV=1" "0.000" "False" "5.859" "1" "1" "1" "1" "847" "97.3" "7.74" "3.88" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "79675" "ENSG00000138399" "FASTKD1" "hsa:79675; Q53R41; Q8N583; Q8TEA9; Q96JM5; Q96N71; Q9H6T4" "" "" "0" "0" "1.181" "0.766" "1.132" "1.041" "1.070" "1.216" "1.011" "0.871" "1.196" "78.1" "92.2" "59.8" "88.4" "81.2" "83.5" "95.0" "79.0" "68.0" "93.3" "" "" "" "" "" "" "" "" "" "" "78.1" "78.0" "37.8" "64.4" "66.6" "64.9" "73.2" "67.9" "53.1" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "5.854" "4" "2" "4" "2" "367" "41.0" "9.00" "9.66" "2" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Voltage gated Potassium channels" "3" "0" "0.877" "1.017" "0.973" "0.970" "0.943" "1.168" "0.976" "1.003" "1.075" "54.7" "48.0" "55.6" "53.2" "53.1" "51.6" "63.9" "53.4" "54.9" "58.8" "" "" "" "" "" "" "" "" "" "" "54.7" "40.6" "35.2" "38.8" "43.5" "40.0" "49.3" "45.9" "42.8" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.000" "False" "5.852" "10" "2" "2" "2" "220" "25.4" "10.07" "5.73" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "" "tRNA processing in the nucleus" "1" "0" "0.919" "0.999" "0.724" "0.798" "0.848" "0.917" "0.668" "0.692" "1.036" "15.0" "13.8" "15.0" "10.9" "12.0" "12.8" "13.8" "10.1" "10.4" "15.6" "" "" "" "" "" "" "" "" "" "" "15.0" "11.7" "9.5" "7.9" "9.8" "9.9" "10.6" "8.6" "8.1" "14.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3952694843308391532" "False" "High" "IsMasterProtein" "O00257" "E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3" "0.000" "False" "5.840" "3" "1" "1" "1" "560" "61.3" "9.36" "3.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "8535" "ENSG00000141582" "CBX4" "B1PJR7; hsa:8535; O00257; Q6TPI8; Q96C04" "" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "8" "0" "1.061" "1.059" "1.213" "1.118" "1.233" "1.156" "1.154" "0.950" "1.201" "61.3" "65.1" "64.9" "74.4" "68.6" "75.6" "70.9" "70.7" "58.2" "73.6" "" "" "" "" "" "" "" "" "" "" "61.3" "55.0" "41.1" "54.2" "56.2" "58.7" "54.6" "60.8" "45.4" "66.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8672256548106462340" "False" "High" "IsMasterProtein" "Q9UJC3" "Protein Hook homolog 1 OS=Homo sapiens OX=9606 GN=HOOK1 PE=1 SV=2" "0.000" "False" "5.828" "2" "2" "2" "1" "728" "84.6" "5.15" "6.09" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "51361" "ENSG00000134709" "HOOK1" "A8K8E9; A8MU44; B4DX15; hsa:51361; O60561; Q5TG44; Q9UJC3" "" "" "0" "0" "0.989" "0.742" "0.846" "0.991" "0.841" "0.864" "0.969" "0.941" "0.930" "57.8" "57.2" "42.9" "48.9" "57.3" "48.6" "50.0" "56.0" "54.4" "53.8" "" "" "" "" "" "" "" "" "" "" "57.8" "48.4" "27.1" "35.7" "46.9" "37.7" "38.5" "48.2" "42.4" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "High" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.000" "False" "5.828" "5" "2" "2" "2" "339" "39.0" "6.83" "5.80" "2" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "11" "0" "0.998" "0.826" "1.033" "0.979" "0.691" "1.057" "0.932" "0.858" "1.000" "164.0" "163.6" "135.4" "169.4" "160.6" "113.3" "173.3" "152.8" "140.8" "164.0" "" "" "" "" "" "" "" "" "" "" "164.0" "138.4" "85.6" "123.5" "131.5" "88.0" "133.6" "131.4" "109.9" "147.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "5.824" "22" "2" "4" "2" "95" "10.5" "8.18" "6.26" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "" "Mitochondrial protein import" "1" "0" "1.093" "1.199" "1.271" "1.106" "1.218" "1.209" "1.115" "1.188" "1.002" "135.4" "148.0" "162.4" "172.1" "149.8" "165.0" "163.7" "151.0" "160.9" "135.7" "" "" "" "" "" "" "" "" "" "" "135.4" "125.3" "102.7" "125.5" "122.7" "128.1" "126.2" "129.8" "125.6" "122.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3120416085995135144" "False" "High" "IsMasterProtein" "Q8N961" "Ankyrin repeat and BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ABTB2 PE=1 SV=2" "0.000" "False" "5.823" "2" "1" "2" "1" "1025" "113.6" "6.29" "5.53" "1" "other biological processes" "" "other molecular function" "Pf00651, Pf12796" "25841" "ENSG00000166016" "ABTB2" "A8K6S9; E9PRW7; hsa:25841; Q52LD6; Q6MZW4; Q8N961; Q8NB44" "" "" "0" "0" "1.442" "1.650" "1.956" "1.623" "1.792" "2.254" "1.683" "1.795" "1.982" "16.8" "24.2" "27.7" "32.8" "27.2" "30.1" "37.8" "28.3" "30.1" "33.3" "" "" "" "" "" "" "" "" "" "" "16.8" "20.5" "17.5" "23.9" "22.3" "23.4" "29.2" "24.3" "23.5" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.000" "False" "5.823" "3" "2" "3" "2" "596" "65.3" "8.35" "8.48" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "1.139" "0.992" "0.954" "1.081" "1.210" "1.038" "1.046" "0.988" "1.067" "108.0" "123.1" "107.2" "103.0" "116.8" "130.8" "112.2" "113.0" "106.8" "115.2" "" "" "" "" "" "" "" "" "" "" "108.0" "104.1" "67.8" "75.1" "95.7" "101.5" "86.5" "97.2" "83.3" "103.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.000" "False" "5.817" "10" "2" "2" "2" "194" "22.6" "5.33" "5.21" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.202" "0.742" "1.304" "1.191" "0.943" "1.090" "1.170" "1.094" "1.265" "54.3" "65.3" "40.3" "70.9" "64.7" "51.2" "59.2" "63.6" "59.4" "68.7" "" "" "" "" "" "" "" "" "" "" "54.3" "55.3" "25.5" "51.7" "53.0" "39.8" "45.7" "54.7" "46.4" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8022290740510184659" "False" "High" "IsMasterProtein" "P49257" "Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2" "0.000" "False" "5.815" "3" "2" "3" "2" "510" "57.5" "6.77" "9.76" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03388" "3998" "ENSG00000074695" "LMAN1" "hsa:3998; P49257; Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9; Q9UQH0; Q9UQH1; Q9UQH2" "VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "12" "0" "1.045" "0.858" "0.976" "1.235" "0.904" "1.352" "1.216" "0.888" "1.227" "103.5" "108.2" "88.8" "101.0" "127.8" "93.6" "140.0" "125.9" "91.9" "127.1" "" "" "" "" "" "" "" "" "" "" "103.5" "91.6" "56.2" "73.6" "104.7" "72.7" "107.9" "108.3" "71.8" "114.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "5.810" "3" "2" "3" "1" "467" "50.4" "8.75" "9.63" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "0.961" "1.049" "0.876" "0.945" "1.098" "0.917" "1.037" "1.009" "0.924" "173.7" "167.0" "182.3" "152.1" "164.2" "190.8" "159.3" "180.1" "175.4" "160.4" "" "" "" "" "" "" "" "" "" "" "173.7" "141.3" "115.3" "110.9" "134.5" "148.1" "122.8" "154.8" "136.9" "144.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1529683512558084157" "False" "High" "IsMasterProtein" "Q4LE39" "AT-rich interactive domain-containing protein 4B OS=Homo sapiens OX=9606 GN=ARID4B PE=1 SV=2" "0.000" "False" "5.803" "1" "2" "3" "2" "1312" "147.7" "5.12" "8.12" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity" "Pf01388, Pf08169, Pf11717" "51742" "ENSG00000054267" "ARID4B" "A1L465; hsa:51742; Q3MHV4; Q4LE39; Q5HY99; Q5T2C2; Q5T2C3; Q5T2C4; Q5T2C5; Q5T2C6; Q6P600; Q86UX1; Q86WR4; Q9H915; Q9NYU3; Q9NZB6; Q9NZG4; Q9P2W4; Q9UF62; Q9Y6E1" "Pathways affected in adenoid cystic carcinoma" "NoRC negatively regulates rRNA expression; Potential therapeutics for SARS; HDACs deacetylate histones" "4" "0" "1.212" "0.933" "1.232" "1.389" "1.134" "1.166" "1.168" "1.056" "1.368" "36.8" "44.6" "34.3" "45.3" "51.1" "41.7" "42.9" "42.9" "38.8" "50.3" "" "" "" "" "" "" "" "" "" "" "36.8" "37.7" "21.7" "33.0" "41.8" "32.4" "33.0" "36.9" "30.3" "45.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "5.800" "1" "1" "1" "1" "952" "105.3" "6.00" "4.22" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "3" "0" "1.040" "1.508" "1.327" "1.188" "1.383" "1.627" "1.236" "1.465" "1.244" "74.3" "77.3" "112.0" "98.6" "88.3" "102.8" "120.9" "91.8" "108.9" "92.4" "" "" "" "" "" "" "" "" "" "" "74.3" "65.4" "70.8" "71.9" "72.3" "79.8" "93.2" "79.0" "85.0" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.000" "False" "5.794" "6" "1" "2" "1" "252" "27.6" "9.61" "6.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion" "3" "0" "1.092" "0.624" "1.065" "1.130" "0.829" "1.102" "1.033" "0.658" "0.889" "83.5" "91.1" "52.1" "88.9" "94.3" "69.2" "92.0" "86.2" "54.9" "74.2" "" "" "" "" "" "" "" "" "" "" "83.5" "77.1" "32.9" "64.8" "77.3" "53.7" "70.9" "74.1" "42.8" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1991915273317640998" "False" "High" "IsMasterProtein" "O00463" "TNF receptor-associated factor 5 OS=Homo sapiens OX=9606 GN=TRAF5 PE=1 SV=2" "0.000" "False" "5.783" "3" "2" "2" "1" "557" "64.4" "7.43" "3.63" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7188" "ENSG00000082512" "TRAF5" "B4DIS9; B4E0A2; hsa:7188; O00463; Q6FHY1" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; 1p36 copy number variation syndrome; 13q12.12 copy number variation" "" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "5.762" "2" "2" "2" "2" "1241" "136.9" "6.29" "5.13" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Proximal tubule transport" "Bicarbonate transporters" "2" "0" "0.957" "0.983" "0.963" "0.918" "1.239" "1.156" "1.020" "1.214" "1.076" "60.4" "57.8" "59.4" "58.2" "55.5" "74.9" "69.9" "61.6" "73.3" "65.0" "" "" "" "" "" "" "" "" "" "" "60.4" "48.9" "37.6" "42.4" "45.4" "58.1" "53.9" "53.0" "57.2" "58.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890677899884632439" "False" "High" "IsMasterProtein" "Q01201" "Transcription factor RelB OS=Homo sapiens OX=9606 GN=RELB PE=1 SV=2" "0.000" "False" "5.754" "4" "2" "2" "2" "579" "62.1" "6.24" "4.96" "2" "stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179, Pf16180, Pf16181" "5971" "ENSG00000104856" "RELB" "hsa:5971; Q01201; Q6GTX7; Q9UEI7" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; EDA signaling in hair follicle development; Ebola virus infection in host; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Osteoarthritic chondrocyte hypertrophy" "CD209 (DC-SIGN) signaling; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling" "14" "0" "0.960" "0.706" "0.931" "0.871" "0.751" "0.936" "0.944" "0.660" "0.947" "116.1" "111.4" "81.9" "108.1" "101.1" "87.2" "108.7" "109.6" "76.6" "109.9" "" "" "" "" "" "" "" "" "" "" "116.1" "94.3" "51.8" "78.8" "82.8" "67.7" "83.8" "94.2" "59.8" "98.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "5.740" "7" "2" "2" "2" "245" "28.2" "6.23" "6.66" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Metapathway biotransformation Phase I and II; Methylation pathways" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635059186967103870" "False" "High" "IsMasterProtein" "Q96PC3" "AP-1 complex subunit sigma-3 OS=Homo sapiens OX=9606 GN=AP1S3 PE=1 SV=1" "0.000" "False" "5.737" "10" "2" "4" "1" "154" "18.3" "6.79" "11.26" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "130340" "ENSG00000152056" "AP1S3" "B4DQZ1; hsa:130340; Q8WTY1; Q96DD1; Q96PC3" "" "MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944436007343456073" "False" "High" "IsMasterProtein" "Q9H7B4" "Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4" "0.000" "False" "5.728" "3" "1" "1" "1" "428" "49.1" "7.25" "3.61" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01753" "64754" "ENSG00000185420" "SMYD3" "A8K0P0; B1AN38; hsa:64754; Q86TL8; Q8N5Z6; Q96AI5; Q9H7B4" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "1.048" "0.917" "0.875" "1.026" "0.872" "0.975" "1.039" "0.855" "1.101" "27.7" "29.0" "25.3" "24.2" "28.4" "24.1" "27.0" "28.7" "23.6" "30.4" "" "" "" "" "" "" "" "" "" "" "27.7" "24.5" "16.0" "17.6" "23.2" "18.7" "20.8" "24.7" "18.4" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1864840127282000894" "False" "High" "IsMasterProtein" "Q9Y2I1" "Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3" "0.000" "False" "5.716" "2" "3" "3" "3" "1504" "166.5" "5.14" "7.55" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787" "11188" "ENSG00000010322" "NISCH" "C9J245; hsa:11188; Q6PGP3; Q6PIB4; Q7L8M3; Q7Z2X6; Q9UES6; Q9UEU4; Q9UFW3; Q9Y2I1" "" "RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle" "3" "0" "1.012" "1.198" "1.069" "0.978" "1.011" "0.999" "1.021" "0.915" "0.863" "140.9" "142.5" "168.7" "150.5" "137.7" "142.4" "140.7" "143.8" "128.9" "121.5" "" "" "" "" "" "" "" "" "" "" "140.9" "120.6" "106.7" "109.7" "112.8" "110.6" "108.5" "123.7" "100.6" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "5.713" "2" "2" "2" "2" "1076" "122.9" "6.35" "6.34" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "5.713" "7" "1" "1" "1" "243" "26.5" "4.78" "5.03" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "Role of LAT2/NTAL/LAB on calcium mobilization" "3" "0" "1.234" "1.091" "1.359" "1.098" "1.197" "0.974" "1.476" "0.827" "0.989" "21.0" "25.9" "22.9" "28.5" "23.0" "25.1" "20.4" "31.0" "17.3" "20.7" "" "" "" "" "" "" "" "" "" "" "21.0" "21.9" "14.5" "20.8" "18.9" "19.5" "15.7" "26.6" "13.5" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "5.711" "5" "2" "2" "2" "357" "39.3" "8.10" "6.83" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.045" "0.826" "0.993" "0.865" "0.853" "0.702" "0.765" "1.022" "0.995" "147.0" "153.6" "121.4" "145.9" "127.2" "125.3" "103.2" "112.4" "150.2" "146.2" "" "" "" "" "" "" "" "" "" "" "147.0" "130.0" "76.8" "106.4" "104.2" "97.3" "79.6" "96.7" "117.2" "131.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "77131538121857207" "False" "High" "IsMasterProtein" "Q9H3D4" "Tumor protein 63 OS=Homo sapiens OX=9606 GN=TP63 PE=1 SV=1" "0.000" "False" "5.708" "2" "1" "1" "1" "680" "76.7" "6.57" "3.78" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00870, Pf07647, Pf07710" "8626" "ENSG00000073282" "TP63" "hsa:8626; O75080; O75195; O75922; O76078; Q6VEG2; Q6VEG3; Q6VEG4; Q6VFJ1; Q6VFJ2; Q6VFJ3; Q6VH20; Q7LDI3; Q7LDI4; Q7LDI5; Q96KR0; Q9H3D2; Q9H3D3; Q9H3D4; Q9H3P8; Q9NPH7; Q9P1B4; Q9P1B5; Q9P1B6; Q9P1B7; Q9UBV9; Q9UE10; Q9UP26; Q9UP27; Q9UP28; Q9UP74" "TP53 network; Apoptosis; Head and neck squamous cell carcinoma; Primary ovarian insufficiency" "TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Metabolic Genes; TP53 Regulates Transcription of Caspase Activators and Caspases; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Pyroptosis" "12" "0" "0.812" "0.842" "0.960" "0.872" "0.790" "1.221" "0.938" "0.747" "0.922" "23.1" "18.7" "19.4" "22.2" "20.1" "18.2" "28.2" "21.7" "17.2" "21.3" "" "" "" "" "" "" "" "" "" "" "23.1" "15.9" "12.3" "16.2" "16.5" "14.2" "21.7" "18.6" "13.5" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7256809200695467141" "False" "High" "IsMasterProtein" "Q02083" "N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3" "0.000" "False" "5.696" "6" "3" "3" "3" "359" "40.0" "8.75" "8.30" "3" "other metabolic processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "27163" "ENSG00000138744" "NAAA" "hsa:27163; Q02083; Q5KTF2; Q96EY2; Q9BRA8" "" "Neurotransmitter release cycle" "1" "0" "1.075" "0.895" "0.991" "1.053" "0.994" "1.009" "1.039" "1.017" "0.954" "228.4" "245.5" "204.5" "226.3" "240.5" "227.1" "230.4" "237.2" "232.2" "217.9" "" "" "" "" "" "" "" "" "" "" "228.4" "207.7" "129.3" "165.0" "197.0" "176.3" "177.6" "204.0" "181.3" "195.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5295951375825513477" "False" "High" "IsMasterProtein" "Q14186" "Transcription factor Dp-1 OS=Homo sapiens OX=9606 GN=TFDP1 PE=1 SV=1" "0.000" "False" "5.696" "9" "2" "2" "2" "410" "45.0" "6.05" "6.04" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf08781" "7027" "ENSG00000198176" "TFDP1" "B4DLQ9; hsa:7027; Q14186; Q5JSB4; Q8IZL5" "Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control; DYRK1A involvement regarding cell proliferation in brain development" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Transcriptional Regulation by E2F6; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; Transcriptional regulation of granulopoiesis; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2603490362497748862" "False" "High" "IsMasterProtein" "P49961" "Ectonucleoside triphosphate diphosphohydrolase 1 OS=Homo sapiens OX=9606 GN=ENTPD1 PE=1 SV=1" "0.000" "False" "5.691" "5" "3" "3" "3" "510" "57.9" "6.34" "7.55" "3" "cell adhesion;other metabolic processes;stress response" "plasma membrane;other membranes" "other molecular function" "Pf01150" "953" "ENSG00000138185" "ENTPD1" "A9Z1X8; B4DWB9; B4E1X1; B7Z599; G3XAF6; hsa:953; P49961; Q5T561; Q5T562; Q86VV3; Q9UQQ9; Q9Y3Q9" "Pyrimidine metabolism" "Purinergic signaling in leishmaniasis infection; Phosphate bond hydrolysis by NTPDase proteins" "3" "0" "1.017" "0.988" "0.998" "1.015" "1.055" "1.088" "0.975" "1.115" "1.027" "164.7" "167.5" "162.8" "164.3" "167.1" "173.7" "179.2" "160.5" "183.6" "169.2" "" "" "" "" "" "" "" "" "" "" "164.7" "141.7" "102.9" "119.8" "136.9" "134.9" "138.1" "138.0" "143.3" "152.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "5.677" "2" "1" "1" "1" "583" "62.8" "6.44" "3.66" "1" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "65" "0" "0.927" "0.823" "0.884" "1.115" "0.908" "1.042" "0.940" "0.819" "0.938" "36.3" "33.7" "29.9" "32.1" "40.5" "33.0" "37.8" "34.1" "29.7" "34.0" "" "" "" "" "" "" "" "" "" "" "36.3" "28.5" "18.9" "23.4" "33.2" "25.6" "29.1" "29.3" "23.2" "30.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.000" "False" "5.673" "8" "3" "3" "3" "315" "34.6" "4.64" "8.31" "3" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "0.908" "0.685" "1.169" "0.836" "0.870" "0.743" "0.760" "0.950" "1.194" "25.9" "23.5" "17.7" "30.3" "21.6" "22.5" "19.3" "19.7" "24.6" "30.9" "" "" "" "" "" "" "" "" "" "" "25.9" "19.9" "11.2" "22.1" "17.7" "17.5" "14.8" "16.9" "19.2" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2783430516031168393" "False" "High" "IsMasterProtein" "Q8IYT2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens OX=9606 GN=CMTR2 PE=1 SV=2" "0.000" "False" "5.668" "1" "1" "1" "1" "770" "88.1" "7.01" "3.43" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01728" "55783" "ENSG00000180917" "CMTR2" "B2RCD5; D3DWS1; hsa:55783; Q8IYT2; Q8NE77; Q8NFR5; Q9H8Z4; Q9NUS3; Q9NXF5" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6979715234218397145" "False" "High" "IsMasterProtein" "Q9BVC3" "Sister chromatid cohesion protein DCC1 OS=Homo sapiens OX=9606 GN=DSCC1 PE=1 SV=2" "0.000" "False" "5.663" "3" "1" "1" "1" "393" "44.8" "5.17" "4.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09724" "79075" "ENSG00000136982" "DSCC1" "hsa:79075; Q969N5; Q9BVC3" "Gastric cancer network 2" "Polymerase switching on the C-strand of the telomere" "2" "0" "1.104" "0.805" "1.344" "0.993" "0.765" "0.944" "1.290" "0.779" "0.886" "69.9" "77.2" "56.3" "94.0" "69.4" "53.5" "66.0" "90.2" "54.5" "61.9" "" "" "" "" "" "" "" "" "" "" "69.9" "65.3" "35.6" "68.5" "56.8" "41.5" "50.8" "77.5" "42.5" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.000" "False" "5.660" "3" "1" "1" "1" "332" "37.8" "6.99" "4.03" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.944" "1.010" "1.235" "1.090" "0.948" "1.062" "1.059" "0.919" "1.022" "84.0" "79.3" "84.8" "103.7" "91.5" "79.6" "89.2" "88.9" "77.1" "85.8" "" "" "" "" "" "" "" "" "" "" "84.0" "67.1" "53.6" "75.6" "75.0" "61.8" "68.7" "76.5" "60.2" "77.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340635961720124479" "False" "High" "IsMasterProtein" "O75140" "GATOR1 complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5 PE=1 SV=2" "0.000" "False" "5.649" "1" "2" "2" "2" "1603" "181.1" "6.73" "3.96" "2" "stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00610, Pf12257, Pf19418" "9681" "ENSG00000100150" "DEPDC5" "A6H8V6; A8MPX9; B4DH93; B9EGN9; hsa:9681; O75140; Q5K3V5; Q5THY9; Q5THZ0; Q5THZ1; Q5THZ3; Q68DR1; Q6MZX3; Q6PEZ1; Q9UGV8; Q9UH13" "22q11.2 copy number variation syndrome" "Amino acids regulate mTORC1" "2" "0" "0.970" "0.817" "0.801" "1.171" "0.607" "1.054" "0.990" "0.943" "0.744" "16.2" "15.7" "13.2" "12.9" "18.9" "9.8" "17.0" "16.0" "15.2" "12.0" "" "" "" "" "" "" "" "" "" "" "16.2" "13.3" "8.3" "9.4" "15.5" "7.6" "13.1" "13.8" "11.9" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932263568853688601" "False" "High" "IsMasterProtein" "Q9UKA9" "Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1" "0.000" "False" "5.648" "3" "2" "2" "1" "531" "57.5" "8.66" "5.14" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "58155" "ENSG00000117569" "PTBP2" "hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9" "Genes targeted by miRNAs in adipocytes; mRNA processing" "" "2" "0" "1.052" "1.018" "1.150" "0.974" "0.953" "0.924" "0.949" "0.931" "0.793" "45.5" "47.9" "46.3" "52.3" "44.3" "43.3" "42.0" "43.2" "42.3" "36.1" "" "" "" "" "" "" "" "" "" "" "45.5" "40.5" "29.3" "38.1" "36.3" "33.7" "32.4" "37.1" "33.0" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "5.645" "19" "3" "3" "3" "109" "12.4" "6.62" "8.44" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "Eukaryotic transcription initiation" "Estrogen-dependent gene expression; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "0.996" "0.988" "0.971" "0.975" "1.135" "0.888" "0.961" "1.044" "1.145" "74.8" "74.5" "73.9" "72.7" "73.0" "84.9" "66.5" "71.9" "78.1" "85.6" "" "" "" "" "" "" "" "" "" "" "74.8" "63.1" "46.7" "53.0" "59.8" "66.0" "51.2" "61.8" "61.0" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746729675254705765" "False" "High" "IsMasterProtein" "Q6ZN18" "Zinc finger protein AEBP2 OS=Homo sapiens OX=9606 GN=AEBP2 PE=1 SV=2" "0.000" "False" "5.637" "4" "2" "2" "2" "517" "54.4" "5.21" "5.43" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "121536" "ENSG00000139154" "AEBP2" "hsa:121536; Q59FS5; Q6ZN18; Q6ZN62; Q96BG3" "Histone modifications; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2)" "PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "5" "0" "0.969" "0.983" "1.043" "1.019" "0.966" "1.051" "1.018" "1.019" "0.934" "171.4" "166.0" "168.5" "178.7" "174.6" "165.6" "180.1" "174.5" "174.6" "160.1" "" "" "" "" "" "" "" "" "" "" "171.4" "140.5" "106.6" "130.3" "143.1" "128.6" "138.8" "150.0" "136.3" "143.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "5.635" "1" "3" "3" "3" "1608" "181.6" "6.32" "7.74" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "5.624" "3" "2" "3" "2" "706" "79.1" "6.32" "6.97" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "" "RHOD GTPase cycle; RHOF GTPase cycle; Miscellaneous transport and binding events" "3" "0" "1.487" "1.188" "1.356" "1.404" "1.012" "1.304" "1.392" "1.590" "1.457" "24.3" "36.2" "28.9" "33.0" "34.2" "24.6" "31.7" "33.9" "38.7" "35.4" "" "" "" "" "" "" "" "" "" "" "24.3" "30.6" "18.3" "24.1" "28.0" "19.1" "24.4" "29.1" "30.2" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "5.620" "8" "1" "3" "1" "133" "14.4" "10.17" "4.84" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.115" "1.126" "1.214" "1.279" "1.336" "1.372" "1.239" "1.242" "1.478" "25.9" "28.9" "29.2" "31.4" "33.1" "34.6" "35.5" "32.1" "32.2" "38.3" "" "" "" "" "" "" "" "" "" "" "25.9" "24.4" "18.4" "22.9" "27.1" "26.9" "27.4" "27.6" "25.1" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "10965468186403699" "False" "High" "IsMasterProtein" "Q8WY54" "Protein phosphatase 1E OS=Homo sapiens OX=9606 GN=PPM1E PE=1 SV=3" "0.000" "False" "5.616" "2" "1" "1" "1" "755" "83.9" "5.01" "4.45" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00481" "22843" "ENSG00000175175" "PPM1E" "A7E2X1; hsa:22843; Q68DW1; Q7LAF3; Q8WY54; Q9UPT0" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "0.763" "0.868" "0.878" "0.879" "0.927" "0.786" "0.826" "0.983" "0.957" "97.5" "74.4" "84.6" "85.6" "85.7" "90.4" "76.6" "80.6" "95.9" "93.3" "" "" "" "" "" "" "" "" "" "" "97.5" "62.9" "53.5" "62.4" "70.2" "70.2" "59.1" "69.3" "74.8" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "5.614" "5" "3" "3" "3" "594" "68.2" "5.33" "7.58" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.922" "1.002" "1.140" "1.177" "1.063" "1.132" "0.996" "1.100" "0.972" "111.0" "102.3" "111.2" "126.6" "130.6" "118.0" "125.7" "110.6" "122.2" "107.9" "" "" "" "" "" "" "" "" "" "" "111.0" "86.6" "70.3" "92.3" "107.0" "91.6" "96.9" "95.1" "95.3" "97.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "5.613" "6" "1" "2" "1" "182" "20.1" "8.02" "5.40" "1" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "Vasopressin-regulated water reabsorption" "COPI-mediated anterograde transport; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5657020156058980872" "False" "High" "IsMasterProtein" "Q9UK22" "F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2" "0.000" "False" "5.611" "6" "1" "1" "1" "296" "33.3" "4.37" "4.75" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26232" "ENSG00000116661" "FBXO2" "B2R7K7; hsa:26232; Q5TGY0; Q6FGJ7; Q8TB29; Q9UK22; Q9UKC6" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.874" "0.535" "0.927" "0.836" "0.916" "0.861" "0.911" "0.748" "0.749" "37.3" "32.6" "19.9" "34.5" "31.1" "34.1" "32.1" "33.9" "27.9" "27.9" "" "" "" "" "" "" "" "" "" "" "37.3" "27.5" "12.6" "25.2" "25.5" "26.5" "24.7" "29.2" "21.7" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8918324511185795548" "False" "High" "IsMasterProtein" "Q9BVC4" "Target of rapamycin complex subunit LST8 OS=Homo sapiens OX=9606 GN=MLST8 PE=1 SV=1" "0.000" "False" "5.608" "4" "1" "1" "1" "326" "35.9" "5.86" "3.60" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00400" "64223" "ENSG00000167965" "MLST8" "B3KMM4; B4DY00; D3DU88; hsa:64223; Q5M800; Q86Y18; Q8WUI5; Q9BVC4; Q9HA66; Q9UJV6" "Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "34" "0" "0.970" "0.865" "1.064" "1.073" "0.912" "0.960" "1.247" "0.900" "0.935" "38.2" "37.1" "33.0" "40.6" "41.0" "34.8" "36.7" "47.6" "34.4" "35.7" "" "" "" "" "" "" "" "" "" "" "38.2" "31.3" "20.9" "29.6" "33.6" "27.1" "28.3" "41.0" "26.8" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "5.606" "4" "1" "1" "1" "301" "34.3" "4.73" "4.22" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "1" "0" "1.049" "1.077" "1.045" "0.785" "0.903" "1.021" "1.045" "0.821" "1.246" "62.4" "65.5" "67.2" "65.3" "49.0" "56.4" "63.7" "65.2" "51.2" "77.8" "" "" "" "" "" "" "" "" "" "" "62.4" "55.4" "42.5" "47.6" "40.2" "43.8" "49.1" "56.1" "40.0" "69.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "5.601" "5" "1" "1" "1" "245" "26.7" "7.65" "4.43" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "" "Synthesis of Ketone Bodies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8336959389003651340" "False" "High" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0.000" "False" "5.596" "0" "2" "2" "2" "4579" "520.8" "7.05" "6.14" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "13q12.12 copy number variation" "" "1" "0" "0.804" "0.782" "1.018" "0.838" "0.814" "0.914" "0.893" "0.918" "0.930" "76.2" "61.3" "59.6" "77.6" "63.9" "62.0" "69.7" "68.1" "70.0" "70.9" "" "" "" "" "" "" "" "" "" "" "76.2" "51.8" "37.7" "56.6" "52.4" "48.2" "53.7" "58.5" "54.6" "63.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "5.594" "7" "2" "2" "2" "206" "24.5" "9.63" "6.65" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "22q11.2 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "5.589" "10" "2" "2" "2" "221" "23.6" "7.03" "3.17" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.042" "0.663" "1.106" "1.029" "0.864" "0.963" "0.991" "0.750" "0.867" "46.8" "48.7" "31.0" "51.7" "48.1" "40.4" "45.0" "46.3" "35.1" "40.5" "" "" "" "" "" "" "" "" "" "" "46.8" "41.2" "19.6" "37.7" "39.4" "31.4" "34.7" "39.8" "27.4" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "5.586" "4" "3" "3" "3" "582" "64.8" "8.46" "6.88" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7648847178929813829" "False" "High" "IsMasterProtein" "Q9H1K0" "Rabenosyn-5 OS=Homo sapiens OX=9606 GN=RBSN PE=1 SV=2" "0.000" "False" "5.585" "3" "2" "2" "2" "784" "88.8" "5.50" "6.00" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11464, Pf16601" "64145" "ENSG00000131381" "RBSN" "B4DWY8; C9J4P5; hsa:64145; Q3KP30; Q59EY8; Q8NAQ1; Q9H1K0" "" "Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "0.941" "0.940" "0.892" "0.924" "1.031" "0.980" "1.046" "0.861" "0.945" "76.7" "72.2" "72.0" "68.4" "70.9" "79.1" "75.1" "80.2" "66.0" "72.5" "" "" "" "" "" "" "" "" "" "" "76.7" "61.1" "45.5" "49.9" "58.1" "61.4" "57.9" "68.9" "51.5" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "High" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.000" "False" "5.583" "9" "3" "3" "3" "337" "36.5" "8.56" "7.70" "3" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "0.907" "0.542" "0.810" "0.937" "0.884" "1.019" "1.131" "0.479" "0.939" "20.8" "18.8" "11.3" "16.8" "19.5" "18.3" "21.2" "23.5" "9.9" "19.5" "" "" "" "" "" "" "" "" "" "" "20.8" "15.9" "7.1" "12.3" "15.9" "14.2" "16.3" "20.2" "7.8" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502282286759796404" "False" "High" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0.000" "False" "5.582" "2" "2" "2" "2" "1230" "138.5" "8.98" "5.06" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "5.577" "2" "1" "1" "1" "524" "56.5" "7.50" "4.46" "1" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "Detoxification of Reactive Oxygen Species" "7" "0" "1.006" "0.823" "0.897" "0.976" "0.953" "0.837" "1.031" "1.115" "0.929" "96.2" "96.9" "79.2" "86.3" "93.9" "91.7" "80.5" "99.2" "107.3" "89.4" "" "" "" "" "" "" "" "" "" "" "96.2" "81.9" "50.1" "62.9" "76.9" "71.2" "62.1" "85.3" "83.7" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "5.561" "6" "2" "2" "2" "284" "30.4" "6.54" "6.19" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "0.976" "1.000" "0.982" "1.061" "0.976" "0.968" "1.021" "1.061" "1.052" "309.5" "302.1" "309.4" "303.9" "328.3" "302.1" "299.6" "316.0" "328.5" "325.7" "" "" "" "" "" "" "" "" "" "" "309.5" "255.6" "195.7" "221.6" "269.0" "234.6" "230.9" "271.7" "256.4" "292.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "5.561" "2" "1" "1" "1" "566" "59.3" "6.20" "3.62" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "" "TYSND1 cleaves peroxisomal proteins" "2" "0" "1.034" "0.824" "1.171" "1.024" "0.988" "1.246" "0.969" "0.873" "0.992" "73.8" "76.4" "60.8" "86.5" "75.6" "72.9" "92.0" "71.6" "64.5" "73.3" "" "" "" "" "" "" "" "" "" "" "73.8" "64.6" "38.4" "63.0" "61.9" "56.6" "70.9" "61.5" "50.3" "65.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2183625062591563072" "False" "High" "IsMasterProtein" "Q9NZT1" "Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2" "0.000" "False" "5.553" "12" "2" "2" "2" "146" "15.9" "4.44" "6.03" "2" "signal transduction;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "51806" "ENSG00000178372" "CALML5" "hsa:51806; Q5SQI3; Q8IXU8; Q9NZT1" "Alzheimer's disease and miRNA effects; Ras signaling; Melanoma; Alzheimer's disease" "Neutrophil degranulation" "5" "0" "1.435" "2.205" "0.965" "1.022" "1.277" "0.649" "1.279" "1.322" "0.889" "98.4" "141.2" "216.9" "95.0" "100.6" "125.6" "63.9" "125.8" "130.1" "87.5" "" "" "" "" "" "" "" "" "" "" "98.4" "119.5" "137.2" "69.3" "82.4" "97.5" "49.2" "108.2" "101.5" "78.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "High" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.000" "False" "5.553" "1" "1" "1" "1" "1238" "138.4" "6.33" "3.36" "1" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "5.553" "3" "2" "2" "2" "639" "70.3" "5.29" "6.14" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "" "TBC/RABGAPs; Amyloid fiber formation" "2" "0" "0.903" "1.040" "1.009" "1.064" "1.065" "0.975" "1.063" "0.805" "0.935" "122.3" "110.4" "127.2" "123.3" "130.2" "130.2" "119.2" "130.0" "98.4" "114.3" "" "" "" "" "" "" "" "" "" "" "122.3" "93.4" "80.4" "89.9" "106.6" "101.1" "91.9" "111.7" "76.8" "102.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8452486629110953776" "False" "High" "IsMasterProtein" "Q9BVC6" "Voltage-gated monoatomic cation channel TMEM109 OS=Homo sapiens OX=9606 GN=TMEM109 PE=1 SV=1" "0.000" "False" "5.549" "5" "1" "1" "1" "243" "26.2" "10.48" "3.59" "1" "stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "transporter activity" "Pf14965" "79073" "ENSG00000110108" "TMEM109" "hsa:79073; Q9BVC6" "" "" "0" "0" "1.341" "1.023" "1.201" "1.237" "1.000" "1.071" "1.176" "1.018" "1.212" "48.9" "65.5" "50.0" "58.7" "60.4" "48.9" "52.3" "57.5" "49.7" "59.2" "" "" "" "" "" "" "" "" "" "" "48.9" "55.4" "31.6" "42.8" "49.5" "38.0" "40.3" "49.4" "38.8" "53.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.000" "False" "5.533" "10" "2" "3" "2" "217" "22.3" "10.92" "6.14" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.915" "1.445" "1.441" "1.187" "1.319" "1.396" "1.392" "1.350" "1.296" "24.2" "22.1" "35.0" "34.9" "28.7" "31.9" "33.8" "33.7" "32.7" "31.4" "" "" "" "" "" "" "" "" "" "" "24.2" "18.7" "22.1" "25.4" "23.5" "24.8" "26.0" "29.0" "25.5" "28.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "5.519" "7" "3" "3" "3" "446" "52.2" "5.02" "7.65" "3" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "1.377" "0.811" "1.068" "1.411" "1.044" "1.261" "1.154" "1.016" "1.150" "32.0" "44.0" "25.9" "34.1" "45.1" "33.4" "40.3" "36.9" "32.5" "36.8" "" "" "" "" "" "" "" "" "" "" "32.0" "37.2" "16.4" "24.9" "36.9" "25.9" "31.1" "31.7" "25.3" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828666302567516124" "False" "High" "IsMasterProtein" "Q6P2H3" "Centrosomal protein of 85 kDa OS=Homo sapiens OX=9606 GN=CEP85 PE=1 SV=1" "0.000" "False" "5.514" "4" "4" "4" "3" "762" "85.6" "6.00" "9.40" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "" "64793" "ENSG00000130695" "CEP85" "B4DRL1; D3DPK4; F8W7K4; hsa:64793; Q5VY68; Q5VY70; Q6P2H3; Q9H6Q1; Q9H828; Q9UF52" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "5.506" "5" "3" "3" "3" "441" "49.9" "5.07" "7.07" "3" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "5.489" "7" "2" "2" "2" "313" "35.4" "6.34" "4.86" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.099" "1.098" "1.239" "1.024" "1.069" "1.073" "1.051" "1.208" "1.070" "101.0" "111.0" "110.9" "125.2" "103.5" "108.0" "108.4" "106.2" "122.0" "108.1" "" "" "" "" "" "" "" "" "" "" "101.0" "93.9" "70.1" "91.3" "84.8" "83.9" "83.6" "91.3" "95.3" "97.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.000" "False" "5.488" "5" "2" "2" "2" "357" "39.7" "8.09" "5.46" "2" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "1.102" "1.040" "1.113" "0.938" "1.172" "0.831" "1.061" "1.193" "1.478" "49.7" "54.8" "51.7" "55.3" "46.7" "58.3" "41.3" "52.7" "59.3" "73.5" "" "" "" "" "" "" "" "" "" "" "49.7" "46.3" "32.7" "40.3" "38.2" "45.2" "31.8" "45.3" "46.3" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "5.479" "1" "1" "1" "1" "989" "110.2" "6.95" "3.87" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.972" "0.940" "1.091" "1.026" "0.797" "1.032" "0.920" "0.917" "1.021" "55.1" "53.5" "51.7" "60.0" "56.5" "43.9" "56.8" "50.7" "50.5" "56.2" "" "" "" "" "" "" "" "" "" "" "55.1" "45.3" "32.7" "43.8" "46.3" "34.1" "43.8" "43.6" "39.4" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605379253823960098" "False" "High" "IsMasterProtein" "Q96Q83" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1" "0.000" "False" "5.475" "11" "3" "3" "3" "286" "33.4" "8.40" "6.92" "3" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf13532" "221120" "ENSG00000166199" "ALKBH3" "A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; Q96Q83" "Direct reversal repair; 11p11.2 copy number variation syndrome" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "1.052" "1.141" "1.198" "1.014" "1.080" "1.303" "1.008" "1.082" "0.976" "58.4" "61.4" "66.6" "69.9" "59.2" "63.1" "76.0" "58.8" "63.1" "57.0" "" "" "" "" "" "" "" "" "" "" "58.4" "51.9" "42.1" "51.0" "48.5" "49.0" "58.6" "50.6" "49.3" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "High" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.000" "False" "5.471" "2" "2" "2" "2" "1133" "125.7" "7.27" "5.18" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-965135399172773459" "False" "High" "IsMasterProtein" "Q00978" "Interferon regulatory factor 9 OS=Homo sapiens OX=9606 GN=IRF9 PE=1 SV=1" "0.000" "False" "5.463" "4" "2" "2" "2" "393" "43.7" "5.77" "5.23" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "10379" "ENSG00000213928; ENSG00000285048" "IRF9" "D3DS61; hsa:10379; Q00978" "Type III interferon signaling; Immune response to tuberculosis; Overview of interferons-mediated signaling pathway; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; p53 transcriptional gene network; Interferon type I signaling pathways; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6075912895449175249" "False" "High" "IsMasterProtein" "Q9NTG7" "NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2" "0.000" "False" "5.462" "3" "1" "1" "1" "399" "43.5" "8.70" "4.67" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23410" "ENSG00000142082" "SIRT3" "B7Z5U6; hsa:23410; Q9NTG7; Q9Y6E8" "Energy metabolism; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Transcriptional activation of mitochondrial biogenesis; Regulation of FOXO transcriptional activity by acetylation" "8" "0" "0.898" "0.928" "0.922" "0.782" "0.773" "0.836" "0.909" "0.836" "0.976" "43.8" "39.3" "40.6" "40.4" "34.2" "33.8" "36.6" "39.8" "36.6" "42.7" "" "" "" "" "" "" "" "" "" "" "43.8" "33.3" "25.7" "29.4" "28.0" "26.3" "28.2" "34.2" "28.6" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6508655288533718058" "False" "High" "IsMasterProtein" "Q9Y666" "Solute carrier family 12 member 7 OS=Homo sapiens OX=9606 GN=SLC12A7 PE=1 SV=3" "0.000" "False" "5.449" "3" "2" "2" "2" "1083" "119.0" "6.71" "5.72" "2" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522" "10723" "ENSG00000113504" "SLC12A7" "A6NDS8; hsa:10723; Q4G0F3; Q96I81; Q9H7I3; Q9H7I7; Q9UFW2; Q9Y666" "" "Cation-coupled Chloride cotransporters" "1" "0" "1.143" "1.048" "1.252" "1.035" "1.073" "1.080" "1.121" "1.054" "0.968" "156.0" "178.3" "163.5" "195.4" "161.4" "167.4" "168.5" "174.9" "164.5" "151.0" "" "" "" "" "" "" "" "" "" "" "156.0" "150.8" "103.4" "142.4" "132.3" "130.0" "129.9" "150.4" "128.4" "135.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "5.435" "10" "3" "3" "3" "320" "33.6" "7.77" "6.47" "3" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "2" "0" "0.935" "0.917" "0.917" "0.996" "0.895" "0.987" "0.940" "0.614" "0.690" "76.0" "71.1" "69.7" "69.7" "75.7" "68.0" "75.0" "71.5" "46.7" "52.4" "" "" "" "" "" "" "" "" "" "" "76.0" "60.1" "44.0" "50.8" "62.0" "52.8" "57.8" "61.5" "36.4" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7586099756274293155" "False" "High" "IsMasterProtein" "Q71UM5" "Ribosomal protein eS27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3" "0.000" "False" "5.434" "23" "2" "3" "1" "84" "9.5" "9.45" "9.47" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01667" "51065" "ENSG00000185088" "RPS27L" "hsa:51065; Q71UM5; Q9BTJ1" "" "Eukaryotic Translation Termination; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842122085258800044" "False" "High" "IsMasterProtein" "Q9BVM4" "Gamma-glutamylaminecyclotransferase OS=Homo sapiens OX=9606 GN=GGACT PE=1 SV=2" "0.000" "False" "5.434" "11" "2" "2" "2" "153" "17.3" "6.87" "5.26" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf06094" "87769" "ENSG00000134864" "GGACT" "B3KTN1; hsa:87769; Q9BT41; Q9BVM4" "" "" "0" "0" "1.143" "0.905" "1.060" "1.154" "1.096" "1.078" "1.068" "1.326" "0.990" "51.2" "58.6" "46.4" "54.3" "59.1" "56.2" "55.3" "54.7" "67.9" "50.7" "" "" "" "" "" "" "" "" "" "" "51.2" "49.5" "29.3" "39.6" "48.4" "43.6" "42.6" "47.0" "53.0" "45.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "High" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.000" "False" "5.431" "4" "2" "2" "2" "671" "75.3" "9.45" "5.00" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "" "Smooth Muscle Contraction" "1" "0" "0.950" "1.021" "0.954" "0.887" "0.956" "0.949" "0.900" "1.161" "1.002" "67.6" "64.2" "69.0" "64.4" "59.9" "64.6" "64.1" "60.8" "78.5" "67.7" "" "" "" "" "" "" "" "" "" "" "67.6" "54.3" "43.6" "47.0" "49.1" "50.2" "49.4" "52.3" "61.2" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1986987314704609604" "False" "High" "IsMasterProtein" "Q8TCU6" "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein OS=Homo sapiens OX=9606 GN=PREX1 PE=1 SV=3" "0.000" "False" "5.425" "1" "2" "2" "2" "1659" "186.1" "6.44" "6.15" "2" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00610, Pf00621" "57580" "ENSG00000124126" "PREX1" "E1P5X9; hsa:57580; Q5JS95; Q5JS96; Q69YL2; Q7Z2L9; Q8TCU6; Q9BQH0; Q9BX55; Q9H4Q6; Q9P2D2; Q9UGQ4" "Chemokine signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711402174933544761" "False" "High" "IsMasterProtein" "Q8NG31" "Kinetochore scaffold 1 OS=Homo sapiens OX=9606 GN=KNL1 PE=1 SV=3" "0.000" "False" "5.419" "1" "2" "2" "2" "2342" "265.2" "5.47" "6.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf18210, Pf19221" "57082" "ENSG00000137812" "KNL1" "hsa:57082; Q8NG31; Q8NHE1; Q8WXA6; Q9HCK2; Q9NR92" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463882674882175167" "False" "High" "IsMasterProtein" "Q5NDL2" "EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1" "0.000" "False" "5.413" "3" "2" "3" "2" "527" "62.0" "7.05" "9.90" "2" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf04577" "285203" "ENSG00000163378" "EOGT" "A8K2U1; B4DFH5; hsa:285203; L7X1M5; Q5NDL2; Q6MZY0; Q6P985; Q6ZTV0" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.045" "1.031" "1.076" "0.959" "1.036" "0.972" "1.025" "1.080" "0.968" "161.7" "169.0" "166.6" "174.0" "155.0" "167.5" "157.1" "165.7" "174.7" "156.6" "" "" "" "" "" "" "" "" "" "" "161.7" "142.9" "105.4" "126.9" "127.0" "130.1" "121.1" "142.5" "136.3" "140.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3309716213588487454" "False" "High" "IsMasterProtein" "Q659C4" "La-related protein 1B OS=Homo sapiens OX=9606 GN=LARP1B PE=1 SV=2" "0.000" "False" "5.409" "2" "2" "3" "1" "914" "105.3" "7.61" "10.34" "2" "other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383, Pf21071" "55132" "ENSG00000138709" "LARP1B" "hsa:55132; Q2YDB6; Q4W599; Q4W5B2; Q659A0; Q659C4; Q6P5X2; Q7Z3F7; Q86VK7; Q8N6F4; Q8N7H4; Q8NAF2; Q9H5E7; Q9NW12" "" "" "0" "0" "0.783" "0.603" "0.863" "0.755" "0.710" "0.822" "0.766" "0.853" "0.831" "25.3" "19.8" "15.3" "21.9" "19.1" "18.0" "20.8" "19.4" "21.6" "21.0" "" "" "" "" "" "" "" "" "" "" "25.3" "16.8" "9.7" "15.9" "15.7" "14.0" "16.1" "16.7" "16.9" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107037615117632570" "False" "High" "IsMasterProtein" "P07992" "DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1" "0.000" "False" "5.408" "7" "2" "2" "2" "297" "32.5" "6.25" "5.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00633, Pf03834" "2067" "ENSG00000012061" "ERCC1" "B2RC01; B3KRR0; hsa:2067; P07992; Q7Z7F5; Q96S40" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "9" "0" "1.020" "0.990" "1.174" "1.022" "1.042" "1.126" "1.073" "1.098" "1.109" "119.9" "122.3" "118.7" "140.8" "122.6" "125.0" "135.0" "128.7" "131.6" "133.0" "" "" "" "" "" "" "" "" "" "" "119.9" "103.5" "75.0" "102.6" "100.4" "97.1" "104.1" "110.6" "102.7" "119.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "5.408" "7" "2" "2" "2" "217" "25.4" "8.63" "5.40" "2" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "1.000" "0.972" "0.964" "0.985" "0.840" "1.008" "0.916" "0.875" "0.972" "281.1" "281.3" "273.4" "270.9" "276.9" "236.2" "283.5" "257.6" "245.9" "273.4" "" "" "" "" "" "" "" "" "" "" "281.1" "238.0" "172.9" "197.5" "226.8" "183.4" "218.5" "221.5" "191.9" "245.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383269344633082517" "False" "High" "IsMasterProtein" "Q8WTW3" "Conserved oligomeric Golgi complex subunit 1 OS=Homo sapiens OX=9606 GN=COG1 PE=1 SV=1" "0.000" "False" "5.395" "3" "3" "3" "3" "980" "108.9" "7.31" "4.94" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf08700" "9382" "ENSG00000166685" "COG1" "hsa:9382; Q8WTW3; Q9NPV9; Q9P2G6" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.918" "0.838" "1.007" "1.008" "0.885" "1.085" "1.096" "0.934" "0.974" "127.4" "116.9" "106.7" "128.2" "128.5" "112.8" "138.1" "139.6" "119.0" "124.0" "" "" "" "" "" "" "" "" "" "" "127.4" "98.9" "67.5" "93.5" "105.2" "87.6" "106.5" "120.1" "92.9" "111.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980978827116582562" "False" "High" "IsMasterProtein" "Q07889" "Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1" "0.000" "False" "5.393" "2" "2" "2" "2" "1333" "152.4" "6.84" "6.10" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6654" "ENSG00000115904" "SOS1" "A8K2G3; B4DXG2; hsa:6654; Q07889" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Acute myeloid leukemia; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling" "120" "0" "1.054" "0.988" "0.900" "0.865" "0.909" "0.948" "0.966" "1.098" "0.924" "105.2" "110.9" "103.9" "94.7" "91.0" "95.6" "99.7" "101.6" "115.4" "97.2" "" "" "" "" "" "" "" "" "" "" "105.2" "93.8" "65.7" "69.0" "74.5" "74.2" "76.8" "87.4" "90.1" "87.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "5.386" "12" "2" "2" "2" "147" "16.7" "7.80" "5.82" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Proteasome degradation" "E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "13" "0" "1.153" "0.811" "0.872" "1.139" "1.182" "1.035" "1.114" "1.098" "1.330" "70.1" "80.9" "56.9" "61.1" "79.9" "82.9" "72.6" "78.1" "77.0" "93.3" "" "" "" "" "" "" "" "" "" "" "70.1" "68.4" "36.0" "44.6" "65.5" "64.4" "55.9" "67.2" "60.1" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "5.379" "3" "3" "3" "2" "753" "80.5" "5.40" "7.75" "3" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "1.376" "1.241" "1.050" "1.201" "1.184" "1.565" "1.514" "1.426" "1.207" "32.4" "44.6" "40.2" "34.0" "38.9" "38.4" "50.7" "49.1" "46.2" "39.1" "" "" "" "" "" "" "" "" "" "" "32.4" "37.7" "25.4" "24.8" "31.9" "29.8" "39.1" "42.2" "36.1" "35.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414831155981605711" "False" "High" "IsMasterProtein" "P06703" "Protein S100-A6 OS=Homo sapiens OX=9606 GN=S100A6 PE=1 SV=1" "0.000" "False" "5.374" "17" "2" "3" "2" "90" "10.2" "5.48" "9.65" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf01023" "6277" "ENSG00000197956" "S100A6" "D3DV39; hsa:6277; P06703; Q5RHS4" "Gastric cancer network 2; Vitamin D receptor pathway; Prostaglandin synthesis and regulation" "" "3" "0" "1.061" "1.078" "1.150" "1.092" "1.136" "1.241" "0.978" "1.110" "1.009" "207.0" "219.7" "223.1" "238.1" "226.0" "235.2" "256.9" "202.4" "229.7" "208.9" "" "" "" "" "" "" "" "" "" "" "207.0" "185.9" "141.1" "173.6" "185.2" "182.6" "198.1" "174.0" "179.3" "187.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8593610449357646347" "False" "High" "IsMasterProtein" "P0C2W1" "F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1" "0.000" "False" "5.370" "4" "1" "1" "1" "286" "30.6" "7.83" "4.11" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf12937" "200933" "ENSG00000174013" "FBXO45" "A6NF90; D3DXB5; hsa:200933; P0C2W1" "3q29 copy number variation syndrome" "" "1" "0" "0.913" "0.842" "1.020" "1.067" "0.824" "1.079" "1.056" "0.965" "0.981" "117.5" "107.3" "98.9" "119.9" "125.4" "96.9" "126.8" "124.1" "113.4" "115.2" "" "" "" "" "" "" "" "" "" "" "117.5" "90.7" "62.6" "87.4" "102.8" "75.2" "97.7" "106.7" "88.5" "103.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2332565569261485395" "False" "High" "IsMasterProtein" "Q9BZL6" "Serine/threonine-protein kinase D2 OS=Homo sapiens OX=9606 GN=PRKD2 PE=1 SV=3" "0.000" "False" "5.370" "2" "2" "2" "1" "878" "96.7" "6.84" "5.36" "2" "cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "25865" "ENSG00000105287" "PRKD2" "B4DTS2; hsa:25865; M0QZW1; M0R2R2; Q8NCK8; Q8TB08; Q9BZL6; Q9P0T6; Q9Y3X8" "VEGFA-VEGFR2 signaling; Gastrin signaling pathway" "Sphingolipid de novo biosynthesis" "3" "1" "1.034" "0.832" "1.222" "1.000" "0.878" "1.153" "1.095" "0.730" "0.931" "82.5" "85.3" "68.7" "100.8" "82.5" "72.5" "95.2" "90.4" "60.2" "76.8" "" "" "" "" "" "" "" "" "" "" "82.5" "72.2" "43.4" "73.5" "67.6" "56.3" "73.4" "77.7" "47.0" "69.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "5.355" "9" "1" "3" "1" "156" "17.4" "4.93" "10.20" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "7" "0" "1.286" "1.035" "0.823" "1.120" "1.440" "1.425" "0.992" "1.302" "1.039" "30.5" "39.2" "31.6" "25.1" "34.2" "43.9" "43.5" "30.2" "39.7" "31.7" "" "" "" "" "" "" "" "" "" "" "30.5" "33.2" "20.0" "18.3" "28.0" "34.1" "33.5" "26.0" "31.0" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "5.354" "10" "1" "1" "1" "126" "14.9" "7.37" "4.11" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "Mitochondrial complex III assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.000" "False" "5.353" "7" "1" "2" "1" "205" "22.3" "7.77" "6.57" "1" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "5.351" "12" "1" "1" "1" "112" "12.1" "8.76" "3.14" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.993" "0.956" "1.167" "1.060" "1.028" "1.084" "0.958" "0.964" "1.157" "51.3" "51.0" "49.1" "59.9" "54.4" "52.8" "55.6" "49.2" "49.5" "59.4" "" "" "" "" "" "" "" "" "" "" "51.3" "43.1" "31.0" "43.7" "44.6" "41.0" "42.9" "42.3" "38.6" "53.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "5.344" "16" "2" "2" "2" "91" "10.7" "4.44" "5.68" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "1.164" "0.930" "1.068" "0.935" "1.010" "1.190" "0.958" "0.906" "0.861" "146.8" "170.9" "136.6" "156.8" "137.3" "148.2" "174.6" "140.6" "133.1" "126.4" "" "" "" "" "" "" "" "" "" "" "146.8" "144.6" "86.3" "114.3" "112.5" "115.1" "134.6" "120.9" "103.9" "113.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2333101891394808779" "False" "High" "IsMasterProtein" "O95573" "Fatty acid CoA ligase Acsl3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3" "0.000" "False" "5.333" "4" "2" "3" "1" "720" "80.4" "8.38" "10.09" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2181" "ENSG00000123983" "ACSL3" "hsa:2181; O95573; Q60I92; Q8IUM9" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110732802669380645" "False" "High" "IsMasterProtein" "P24864" "G1/S-specific cyclin-E1 OS=Homo sapiens OX=9606 GN=CCNE1 PE=1 SV=2" "0.000" "False" "5.325" "5" "2" "2" "2" "410" "47.0" "6.04" "5.24" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "898" "ENSG00000105173" "CCNE1" "A8K684; hsa:898; P24864; Q14091; Q8NFG1; Q92501; Q9UD21" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; p53 transcriptional gene network; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G1/S-Specific Transcription; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "38" "0" "1.013" "1.430" "0.992" "1.079" "1.525" "1.151" "1.027" "1.428" "1.266" "114.8" "116.3" "164.2" "113.9" "123.9" "175.1" "132.2" "117.9" "163.9" "145.3" "" "" "" "" "" "" "" "" "" "" "114.8" "98.4" "103.8" "83.0" "101.5" "135.9" "101.9" "101.4" "128.0" "130.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-68439151188917529" "False" "High" "IsMasterProtein" "P50219" "Motor neuron and pancreas homeobox protein 1 OS=Homo sapiens OX=9606 GN=MNX1 PE=1 SV=3" "0.000" "False" "5.322" "5" "2" "2" "2" "401" "40.5" "7.68" "5.42" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3110" "ENSG00000130675" "MNX1" "F5H401; hsa:3110; P50219; Q9Y648" "" "" "0" "0" "1.268" "0.994" "1.393" "1.350" "1.166" "1.600" "1.592" "1.177" "1.253" "36.2" "46.0" "36.0" "50.5" "48.9" "42.3" "58.0" "57.7" "42.7" "45.4" "" "" "" "" "" "" "" "" "" "" "36.2" "38.9" "22.8" "36.8" "40.1" "32.8" "44.7" "49.6" "33.3" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "5.314" "5" "1" "2" "1" "192" "21.9" "9.95" "6.83" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.024" "1.417" "0.901" "1.173" "1.471" "0.999" "1.382" "1.545" "1.138" "185.9" "190.3" "263.4" "167.5" "218.1" "273.4" "185.7" "256.9" "287.1" "211.6" "" "" "" "" "" "" "" "" "" "" "185.9" "161.0" "166.5" "122.1" "178.7" "212.3" "143.1" "220.9" "224.1" "190.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8964751153975728348" "False" "High" "IsMasterProtein" "Q96RE7" "Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1" "0.000" "False" "5.312" "4" "2" "2" "2" "527" "57.2" "5.74" "5.94" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf10523" "112939" "ENSG00000160877" "NACC1" "hsa:112939; Q96RE7" "" "" "0" "0" "0.851" "0.858" "0.814" "0.857" "0.739" "0.906" "0.806" "0.684" "0.806" "147.7" "125.7" "126.7" "120.2" "126.6" "109.3" "133.9" "119.1" "101.0" "119.0" "" "" "" "" "" "" "" "" "" "" "147.7" "106.3" "80.1" "87.7" "103.7" "84.8" "103.2" "102.4" "78.9" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "5.307" "6" "1" "1" "1" "204" "23.4" "6.01" "3.21" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "RND1 GTPase cycle" "6" "0" "1.150" "0.892" "0.969" "1.074" "1.010" "1.146" "0.852" "0.822" "0.886" "37.6" "43.3" "33.6" "36.5" "40.4" "38.0" "43.1" "32.0" "30.9" "33.3" "" "" "" "" "" "" "" "" "" "" "37.6" "36.6" "21.2" "26.6" "33.1" "29.5" "33.2" "27.5" "24.1" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "5.301" "3" "2" "2" "2" "735" "79.3" "4.91" "3.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3146849743976844279" "False" "High" "IsMasterProtein" "Q02809" "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" "0.000" "False" "5.300" "2" "1" "1" "1" "727" "83.5" "6.95" "3.33" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03171" "5351" "ENSG00000083444" "PLOD1" "B4DR87; hsa:5351; Q02809; Q96AV9; Q9H132" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4776370304497058949" "False" "High" "IsMasterProtein" "Q8IV04" "Carabin OS=Homo sapiens OX=9606 GN=TBC1D10C PE=1 SV=1" "0.000" "False" "5.293" "4" "2" "2" "2" "446" "49.7" "8.76" "6.20" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "374403" "ENSG00000175463" "TBC1D10C" "G3V1D6; hsa:374403; Q8IV04" "" "Neutrophil degranulation; TBC/RABGAPs" "2" "0" "0.998" "0.839" "1.037" "0.925" "0.820" "1.085" "0.849" "0.749" "0.834" "107.9" "107.7" "90.5" "111.8" "99.7" "88.4" "117.1" "91.6" "80.8" "89.9" "" "" "" "" "" "" "" "" "" "" "107.9" "91.1" "57.2" "81.5" "81.7" "68.6" "90.2" "78.8" "63.1" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6257492621702889989" "False" "High" "IsMasterProtein" "Q10589" "Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1" "0.000" "False" "5.290" "6" "1" "1" "1" "180" "19.8" "5.60" "4.05" "1" "stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf16716" "684" "ENSG00000130303" "BST2" "A8K4Y4; hsa:684; Q10589; Q53G07" "Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling" "Neutrophil degranulation; Interferon alpha/beta signaling; SARS-CoV-1 activates/modulates innate immune responses" "5" "0" "1.192" "1.101" "1.161" "1.304" "1.003" "1.342" "1.179" "0.894" "1.253" "70.7" "84.3" "77.9" "82.1" "92.2" "70.9" "94.9" "83.4" "63.2" "88.6" "" "" "" "" "" "" "" "" "" "" "70.7" "71.3" "49.2" "59.9" "75.6" "55.1" "73.2" "71.7" "49.3" "79.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.000" "False" "5.287" "10" "1" "5" "1" "88" "10.4" "10.46" "15.59" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "0.987" "1.127" "1.131" "1.114" "1.176" "1.124" "1.085" "1.102" "1.030" "190.7" "188.2" "214.9" "215.7" "212.6" "224.4" "214.4" "206.9" "210.1" "196.5" "" "" "" "" "" "" "" "" "" "" "190.7" "159.2" "135.9" "157.3" "174.2" "174.2" "165.3" "177.9" "164.0" "176.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.000" "False" "5.278" "4" "1" "1" "1" "443" "49.0" "4.78" "4.99" "1" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "0.971" "1.033" "1.046" "1.221" "0.981" "1.303" "1.129" "0.812" "0.837" "30.6" "29.8" "31.6" "32.0" "37.4" "30.1" "39.9" "34.6" "24.9" "25.6" "" "" "" "" "" "" "" "" "" "" "30.6" "25.2" "20.0" "23.4" "30.6" "23.3" "30.8" "29.8" "19.4" "23.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-750359377190588192" "False" "High" "IsMasterProtein" "O75616" "GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2" "0.000" "False" "5.267" "2" "1" "1" "1" "437" "48.3" "8.84" "3.59" "1" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "translation activity;nucleic acid binding activity;other molecular function" "Pf01926" "26284" "ENSG00000132591" "ERAL1" "B3KN21; C9JEC6; hsa:26284; O75616; O75617; Q8WUY4; Q96LE2; Q96TC0" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "High" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.000" "False" "5.261" "5" "2" "2" "2" "366" "40.7" "4.63" "6.53" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "0.985" "1.304" "1.007" "1.000" "1.201" "1.048" "1.087" "1.028" "1.230" "100.9" "99.5" "131.7" "101.7" "101.0" "121.3" "105.8" "109.7" "103.8" "124.2" "" "" "" "" "" "" "" "" "" "" "100.9" "84.2" "83.3" "74.1" "82.7" "94.2" "81.5" "94.3" "81.0" "111.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2425076065007408183" "False" "High" "IsMasterProtein" "Q9H7F0" "Polyamine-transporting ATPase 13A3 OS=Homo sapiens OX=9606 GN=ATP13A3 PE=1 SV=4" "0.000" "False" "5.247" "1" "1" "1" "1" "1226" "138.0" "6.64" "3.25" "1" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00122, Pf00690, Pf12409, Pf13246" "79572" "ENSG00000133657" "ATP13A3" "hsa:79572; Q8NC11; Q96KS1; Q9H7F0" "" "" "0" "0" "0.910" "1.150" "0.925" "1.175" "1.079" "0.989" "0.970" "1.130" "1.088" "44.6" "40.6" "51.3" "41.3" "52.4" "48.2" "44.1" "43.3" "50.4" "48.6" "" "" "" "" "" "" "" "" "" "" "44.6" "34.4" "32.4" "30.1" "43.0" "37.4" "34.0" "37.2" "39.4" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.000" "False" "5.247" "0" "1" "6" "1" "1693" "189.1" "7.74" "17.34" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Mesodermal commitment pathway; GPR40 pathway" "Synthesis of IP3 and IP4 in the cytosol" "3" "0" "0.946" "1.092" "0.961" "0.932" "0.951" "0.893" "0.898" "1.035" "0.984" "143.3" "135.5" "156.5" "137.7" "133.6" "136.3" "128.0" "128.7" "148.4" "141.0" "" "" "" "" "" "" "" "" "" "" "143.3" "114.7" "99.0" "100.4" "109.4" "105.8" "98.7" "110.6" "115.8" "126.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261642457935236614" "False" "High" "IsMasterProtein" "Q9NS73" "MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2" "0.000" "False" "5.246" "6" "2" "3" "2" "344" "39.3" "7.24" "6.91" "2" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "51562" "ENSG00000151332" "MBIP" "hsa:51562; Q86TZ2; Q96AS5; Q9BS93; Q9NS73; Q9NZE1" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.090" "0.955" "1.035" "1.224" "0.949" "1.041" "1.258" "0.957" "1.057" "130.1" "141.8" "124.2" "134.7" "159.3" "123.5" "135.4" "163.6" "124.6" "137.5" "" "" "" "" "" "" "" "" "" "" "130.1" "120.0" "78.5" "98.2" "130.5" "95.9" "104.4" "140.7" "97.2" "123.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3981645766527825606" "False" "High" "IsMasterProtein" "Q9HC98" "Serine/threonine-protein kinase Nek6 OS=Homo sapiens OX=9606 GN=NEK6 PE=1 SV=2" "0.000" "False" "5.239" "5" "2" "2" "1" "313" "35.7" "8.03" "5.01" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "10783" "ENSG00000119408" "NEK6" "B7Z2D9; hsa:10783; Q5TBG3; Q5TBG9; Q6FG86; Q6IAR3; Q96E83; Q9HC98; Q9ULX2" "" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "3" "1" "0.929" "0.696" "0.872" "0.964" "0.747" "0.894" "0.991" "0.660" "0.884" "265.6" "246.9" "184.9" "231.6" "256.1" "198.4" "237.5" "263.3" "175.2" "234.9" "" "" "" "" "" "" "" "" "" "" "265.6" "208.9" "116.9" "168.9" "209.8" "154.1" "183.0" "226.4" "136.8" "211.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "5.238" "1" "1" "1" "1" "876" "98.4" "9.32" "3.40" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "1.174" "1.135" "1.233" "1.323" "1.127" "1.146" "1.215" "0.973" "1.231" "47.7" "56.0" "54.2" "58.8" "63.2" "53.8" "54.7" "58.0" "46.4" "58.7" "" "" "" "" "" "" "" "" "" "" "47.7" "47.4" "34.3" "42.9" "51.7" "41.8" "42.2" "49.9" "36.3" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-209810513370909151" "False" "High" "IsMasterProtein" "Q8NBJ4" "Golgi membrane protein 1 OS=Homo sapiens OX=9606 GN=GOLM1 PE=1 SV=1" "0.000" "False" "5.236" "5" "1" "1" "1" "401" "45.3" "4.97" "4.55" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi" "" "" "51280" "ENSG00000135052" "GOLM1" "hsa:51280; Q6IAF4; Q8NBJ4; Q9NRB9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "1.040" "1.135" "0.932" "1.057" "1.100" "1.256" "1.243" "0.938" "1.111" "24.5" "25.5" "27.8" "22.9" "25.9" "27.0" "30.8" "30.5" "23.0" "27.3" "" "" "" "" "" "" "" "" "" "" "24.5" "21.6" "17.6" "16.7" "21.3" "20.9" "23.7" "26.2" "18.0" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "742235004239548424" "False" "High" "IsMasterProtein" "Q6ICL3" "Transport and Golgi organization protein 2 homolog OS=Homo sapiens OX=9606 GN=TANGO2 PE=1 SV=1" "0.000" "False" "5.233" "7" "2" "2" "2" "276" "30.9" "5.17" "5.52" "2" "cell organization and biogenesis;transport" "cytosol;mitochondrion;ER/Golgi;other cell component" "" "Pf05742" "128989" "ENSG00000183597" "TANGO2" "A8MUE9; B7WNV6; B7Z583; B7Z730; D3DX23; hsa:128989; Q6ICL3; Q8IW05; Q8NAL0; Q8TCS0; Q96M16" "22q11.2 copy number variation syndrome" "" "1" "0" "1.074" "1.198" "0.831" "0.949" "0.997" "0.939" "0.926" "1.146" "0.929" "32.9" "35.4" "39.5" "27.4" "31.3" "32.8" "30.9" "30.5" "37.8" "30.6" "" "" "" "" "" "" "" "" "" "" "32.9" "29.9" "25.0" "20.0" "25.6" "25.5" "23.8" "26.2" "29.5" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "996701164361086035" "False" "High" "IsMasterProtein" "Q96E29" "Transcription termination factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF3 PE=1 SV=2" "0.000" "False" "5.232" "2" "1" "1" "1" "417" "47.9" "8.53" "3.68" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "nucleic acid binding activity" "Pf02536" "51001" "ENSG00000156469" "MTERF3" "B3KMG6; G3V130; hsa:51001; Q96E29; Q9Y301" "Mitochondrial gene expression" "PINK1-PRKN Mediated Mitophagy" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036196760614096612" "False" "High" "IsMasterProtein" "P11802" "Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2" "0.000" "False" "5.224" "6" "2" "4" "1" "303" "33.7" "7.01" "11.75" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "1019" "ENSG00000135446" "CDK4" "B2R9A0; B4DNF9; hsa:1019; O00576; P11802; Q6FG61" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Bladder cancer; PPAR-alpha pathway; Nuclear receptors meta-pathway; Ovarian infertility; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Sphingolipid metabolism in senescence; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; JAK-STAT signaling in the regulation of beta cells; DNA damage response" "Oxidative Stress Induced Senescence; Transcriptional regulation of white adipocyte differentiation; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; Transcriptional regulation by RUNX2; Meiotic recombination; Transcriptional regulation of granulopoiesis; PTK6 Regulates Cell Cycle; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity" "47" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "5.221" "5" "2" "3" "2" "420" "47.0" "8.73" "8.23" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "" "rRNA modification in the mitochondrion" "1" "0" "1.123" "0.965" "1.141" "1.095" "1.141" "0.835" "1.012" "1.109" "0.999" "58.2" "65.3" "56.2" "66.4" "63.8" "66.4" "48.6" "58.9" "64.6" "58.1" "" "" "" "" "" "" "" "" "" "" "58.2" "55.3" "35.5" "48.4" "52.2" "51.6" "37.5" "50.6" "50.4" "52.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7465059453910529804" "False" "High" "IsMasterProtein" "Q9NSB8" "Homer protein homolog 2 OS=Homo sapiens OX=9606 GN=HOMER2 PE=1 SV=1" "0.000" "False" "5.216" "5" "2" "3" "1" "354" "40.6" "6.38" "4.42" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00568" "9455" "ENSG00000103942" "HOMER2" "hsa:9455; O95269; O95349; Q9NSB6; Q9NSB7; Q9NSB8; Q9UNT7" "15q25 copy number variation; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531343313582380268" "False" "High" "IsMasterProtein" "P42338" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1" "0.000" "False" "5.215" "2" "2" "2" "1" "1070" "122.7" "7.09" "4.21" "2" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5291" "ENSG00000051382" "PIK3CB" "D3DNF0; hsa:5291; P42338; Q24JU2" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Focal adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; VEGFA-VEGFR2 Pathway; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Signaling by CSF1 (M-CSF) in myeloid cells" "74" "0" "0.717" "1.170" "1.680" "1.214" "0.929" "1.757" "1.355" "1.382" "1.252" "11.5" "8.3" "13.5" "19.3" "14.0" "10.7" "20.2" "15.6" "15.9" "14.4" "" "" "" "" "" "" "" "" "" "" "11.5" "7.0" "8.5" "14.1" "11.5" "8.3" "15.6" "13.4" "12.4" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2436656635601103317" "False" "High" "IsMasterProtein" "Q3ZCW2" "Galectin-related protein OS=Homo sapiens OX=9606 GN=LGALSL PE=1 SV=2" "0.000" "False" "5.213" "6" "1" "2" "1" "172" "19.0" "5.35" "5.46" "1" "" "" "other molecular function" "Pf00337" "29094" "ENSG00000119862" "LGALSL" "B2RBG8; D6W5E8; hsa:29094; Q3ZCW2; Q6P5T6; Q9P005" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172063933685251467" "False" "High" "IsMasterProtein" "Q9BTA9" "WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3" "0.000" "False" "5.207" "3" "2" "2" "2" "647" "70.7" "9.45" "2.86" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00397" "51322" "ENSG00000095787" "WAC" "A8K2A9; C9JBT9; D3DRW5; D3DRW6; D3DRW7; hsa:51322; Q53EN9; Q5JU75; Q5JU77; Q5VXK0; Q5VXK2; Q8TCK1; Q96DP3; Q96FW6; Q96JI3; Q9BTA9" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "5.206" "3" "2" "2" "2" "491" "52.4" "5.10" "6.81" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "mRNA Splicing - Major Pathway" "4" "0" "0.915" "0.857" "0.914" "0.941" "0.883" "0.997" "0.987" "0.796" "0.886" "348.7" "319.0" "298.9" "318.7" "328.2" "307.9" "347.7" "344.3" "277.5" "309.1" "" "" "" "" "" "" "" "" "" "" "348.7" "269.9" "189.0" "232.4" "268.9" "239.1" "268.0" "296.0" "216.6" "277.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.000" "True" "5.199" "7" "2" "2" "2" "202" "23.2" "5.87" "5.35" "2" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "0.711" "0.791" "0.744" "0.702" "1.189" "0.772" "0.506" "1.248" "0.778" "96.3" "68.5" "76.1" "71.6" "67.6" "114.5" "74.3" "48.7" "120.1" "74.9" "" "" "" "" "" "" "" "" "" "" "96.3" "57.9" "48.1" "52.2" "55.4" "88.9" "57.3" "41.9" "93.8" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "5.198" "2" "1" "1" "1" "507" "55.0" "7.72" "4.01" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "7" "0" "0.970" "0.975" "1.041" "0.994" "1.116" "1.128" "1.052" "0.921" "1.122" "123.3" "119.6" "120.2" "128.3" "122.6" "137.5" "139.1" "129.7" "113.6" "138.3" "" "" "" "" "" "" "" "" "" "" "123.3" "101.2" "76.0" "93.5" "100.4" "106.8" "107.2" "111.5" "88.7" "124.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5480517122965498200" "False" "High" "IsMasterProtein" "P15735" "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Homo sapiens OX=9606 GN=PHKG2 PE=1 SV=1" "0.000" "False" "5.190" "5" "2" "2" "2" "406" "46.4" "6.38" "6.19" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5261" "ENSG00000156873" "PHKG2" "A8K0C7; B4DEB7; E9PEU3; hsa:5261; P11800; P15735" "Ferroptosis; Glycogen synthesis and degradation; 1p36 copy number variation syndrome" "Glycogen breakdown (glycogenolysis)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.000" "False" "5.188" "13" "1" "1" "1" "92" "10.2" "12.25" "4.27" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.047" "0.996" "0.959" "1.038" "1.190" "1.298" "1.084" "0.975" "1.328" "100.2" "104.9" "99.9" "96.1" "104.0" "119.2" "130.1" "108.7" "97.7" "133.1" "" "" "" "" "" "" "" "" "" "" "100.2" "88.8" "63.1" "70.1" "85.2" "92.6" "100.3" "93.4" "76.2" "119.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8960608706317852180" "False" "High" "IsMasterProtein" "A1L188" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 OS=Homo sapiens OX=9606 GN=NDUFAF8 PE=1 SV=1" "0.000" "False" "5.186" "15" "1" "1" "1" "74" "7.8" "9.32" "3.48" "1" "cell organization and biogenesis" "mitochondrion" "" "" "284184" "ENSG00000224877" "NDUFAF8" "A1L188; hsa:284184" "" "" "0" "0" "0.959" "1.190" "1.119" "1.019" "1.187" "1.231" "0.800" "1.246" "1.184" "53.1" "50.9" "63.2" "59.5" "54.2" "63.1" "65.4" "42.5" "66.2" "62.9" "" "" "" "" "" "" "" "" "" "" "53.1" "43.1" "40.0" "43.4" "44.4" "49.0" "50.4" "36.5" "51.7" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2164411391658513183" "False" "High" "IsMasterProtein" "O94887" "FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3" "0.000" "False" "5.186" "2" "1" "1" "1" "1054" "119.8" "8.79" "4.83" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380" "9855" "ENSG00000006607" "FARP2" "B7Z6J8; F5GZ84; hsa:9855; O94887; Q53QM5; Q8WU27; Q9UFE7" "2q37 copy number variation syndrome; TAR syndrome" "RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "4" "0" "1.155" "1.100" "1.024" "1.167" "1.327" "1.050" "1.118" "1.185" "1.037" "18.6" "21.5" "20.4" "19.0" "21.7" "24.7" "19.5" "20.8" "22.0" "19.3" "" "" "" "" "" "" "" "" "" "" "18.6" "18.2" "12.9" "13.9" "17.8" "19.1" "15.0" "17.9" "17.2" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "5.182" "11" "2" "2" "2" "150" "16.8" "6.79" "6.00" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "Respiratory electron transport; Mitochondrial protein degradation; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "9" "0" "1.036" "1.107" "1.069" "0.949" "1.195" "1.184" "1.079" "1.151" "1.023" "241.2" "249.8" "266.9" "257.8" "228.9" "288.3" "285.5" "260.3" "277.6" "246.8" "" "" "" "" "" "" "" "" "" "" "241.2" "211.4" "168.7" "187.9" "187.5" "223.9" "220.1" "223.8" "216.7" "221.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2812564218304631981" "False" "High" "IsMasterProtein" "Q9NRD1" "F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1" "0.000" "False" "5.180" "4" "1" "1" "1" "293" "33.9" "6.09" "5.18" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26270" "ENSG00000116663" "FBXO6" "B1AK42; B2RC88; hsa:26270; Q9NRD1; Q9UKT3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "0.632" "1.058" "1.471" "1.228" "0.904" "0.820" "0.957" "0.696" "0.828" "15.6" "9.9" "16.5" "23.0" "19.2" "14.1" "12.8" "14.9" "10.9" "12.9" "" "" "" "" "" "" "" "" "" "" "15.6" "8.3" "10.4" "16.7" "15.7" "11.0" "9.9" "12.9" "8.5" "11.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.000" "False" "5.179" "1" "1" "1" "1" "1566" "172.3" "7.69" "4.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "0.931" "1.398" "1.165" "0.714" "1.362" "1.067" "0.880" "1.539" "1.189" "92.3" "85.9" "129.0" "107.4" "65.9" "125.6" "98.4" "81.2" "141.9" "109.7" "" "" "" "" "" "" "" "" "" "" "92.3" "72.7" "81.5" "78.3" "54.0" "97.6" "75.9" "69.8" "110.8" "98.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "5.173" "9" "2" "3" "2" "186" "20.5" "5.41" "8.22" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2050370214376890264" "False" "High" "IsMasterProtein" "O76075" "DNA fragmentation factor subunit beta OS=Homo sapiens OX=9606 GN=DFFB PE=1 SV=1" "0.000" "False" "5.168" "6" "2" "2" "2" "338" "39.1" "9.00" "4.93" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02017, Pf09230" "1677" "ENSG00000169598" "DFFB" "hsa:1677; O60521; O76075; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "0.957" "0.805" "1.051" "1.096" "0.785" "1.030" "1.006" "0.898" "1.058" "200.1" "191.5" "161.0" "210.3" "219.2" "157.1" "206.0" "201.2" "179.7" "211.6" "" "" "" "" "" "" "" "" "" "" "200.1" "162.0" "101.8" "153.4" "179.6" "122.0" "158.8" "173.0" "140.3" "190.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "5.167" "1" "1" "1" "1" "1222" "134.2" "7.20" "4.02" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Alstrom syndrome" "Ovarian tumor domain proteases" "2" "0" "1.101" "1.255" "1.378" "1.227" "0.883" "1.123" "1.059" "1.121" "1.352" "20.5" "22.6" "25.8" "28.3" "25.2" "18.1" "23.1" "21.7" "23.0" "27.7" "" "" "" "" "" "" "" "" "" "" "20.5" "19.1" "16.3" "20.6" "20.6" "14.1" "17.8" "18.7" "18.0" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5474212331785371457" "False" "High" "IsMasterProtein" "Q9P2G3" "Kelch-like protein 14 OS=Homo sapiens OX=9606 GN=KLHL14 PE=1 SV=2" "0.000" "False" "5.160" "4" "2" "2" "2" "628" "70.7" "6.68" "5.62" "2" "" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "57565" "ENSG00000197705" "KLHL14" "A6NNW1; B4DHA0; hsa:57565; Q8WU41; Q9P2G3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2506181633878019200" "False" "High" "IsMasterProtein" "P50548" "ETS domain-containing transcription factor ERF OS=Homo sapiens OX=9606 GN=ERF PE=1 SV=2" "0.000" "False" "5.160" "4" "2" "2" "2" "548" "58.7" "7.30" "5.37" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2077" "ENSG00000105722" "ERF" "B2RAP1; B7Z4R0; hsa:2077; P50548; Q59G38; Q9UPI7" "Ciliary landscape" "Oncogene Induced Senescence" "2" "0" "1.006" "0.881" "1.100" "1.170" "0.861" "1.067" "1.212" "0.865" "0.951" "148.5" "149.5" "130.8" "163.3" "173.7" "127.9" "158.5" "180.1" "128.5" "141.2" "" "" "" "" "" "" "" "" "" "" "148.5" "126.4" "82.7" "119.1" "142.3" "99.4" "122.2" "154.8" "100.3" "127.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.000" "False" "5.143" "1" "2" "2" "2" "1445" "155.2" "6.81" "6.49" "2" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "" "MET interacts with TNS proteins" "1" "0" "1.073" "0.981" "1.156" "1.151" "1.036" "1.274" "1.294" "0.928" "0.991" "87.4" "93.7" "85.7" "101.0" "100.6" "90.5" "111.3" "113.1" "81.1" "86.6" "" "" "" "" "" "" "" "" "" "" "87.4" "79.3" "54.2" "73.6" "82.4" "70.3" "85.8" "97.2" "63.3" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "5.142" "3" "1" "1" "1" "300" "34.4" "6.38" "3.70" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.093" "0.914" "1.085" "1.105" "1.103" "1.078" "1.103" "1.159" "1.079" "53.5" "58.4" "48.9" "58.0" "59.1" "59.0" "57.7" "59.0" "61.9" "57.7" "" "" "" "" "" "" "" "" "" "" "53.5" "49.4" "30.9" "42.3" "48.4" "45.8" "44.4" "50.7" "48.3" "51.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "High" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.000" "False" "5.130" "3" "2" "3" "2" "669" "75.9" "5.86" "9.61" "2" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8281195296370466031" "False" "High" "IsMasterProtein" "P0CG13" "Chromosome transmission fidelity protein 8 homolog OS=Homo sapiens OX=9606 GN=CHTF8 PE=1 SV=1" "0.000" "False" "5.124" "11" "1" "1" "1" "121" "13.3" "8.18" "4.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf09696" "54921" "ENSG00000168802" "CHTF8" "A8MYX8; hsa:54921; P0CG13; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "Gastric cancer network 2" "Polymerase switching on the C-strand of the telomere" "2" "0" "1.161" "1.014" "1.267" "1.029" "1.108" "1.130" "0.994" "0.928" "1.013" "58.4" "67.8" "59.3" "74.0" "60.1" "64.7" "66.0" "58.1" "54.2" "59.2" "" "" "" "" "" "" "" "" "" "" "58.4" "57.4" "37.5" "54.0" "49.2" "50.3" "50.9" "49.9" "42.3" "53.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "5.121" "2" "1" "1" "1" "552" "62.0" "8.31" "3.49" "1" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Glycosaminoglycan degradation" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "5" "0" "0.961" "1.230" "1.184" "1.158" "1.244" "0.953" "1.288" "1.614" "1.167" "29.5" "28.3" "36.3" "34.9" "34.2" "36.7" "28.1" "38.0" "47.6" "34.4" "" "" "" "" "" "" "" "" "" "" "29.5" "24.0" "22.9" "25.5" "28.0" "28.5" "21.7" "32.7" "37.2" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "5.118" "7" "2" "3" "2" "242" "28.6" "6.80" "9.30" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.046" "0.766" "1.211" "1.209" "0.903" "1.175" "1.189" "0.879" "0.941" "203.8" "213.1" "156.0" "246.8" "246.5" "184.0" "239.5" "242.3" "179.2" "191.8" "" "" "" "" "" "" "" "" "" "" "203.8" "180.3" "98.7" "180.0" "201.9" "142.9" "184.6" "208.3" "139.8" "172.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3166111857838769824" "False" "High" "IsMasterProtein" "P46531" "Neurogenic locus notch homolog protein 1 OS=Homo sapiens OX=9606 GN=NOTCH1 PE=1 SV=4" "0.000" "False" "5.115" "1" "2" "2" "2" "2555" "272.3" "5.12" "5.73" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00008, Pf00066, Pf06816, Pf07645, Pf07684, Pf12661, Pf12796, Pf13637" "4851" "ENSG00000148400" "NOTCH1" "hsa:4851; P46531; Q59ED8; Q5SXM3" "Heart development; Neural crest differentiation; Gastric cancer network 1; Cardiac progenitor differentiation; Primary focal segmental glomerulosclerosis (FSGS); Notch signaling; Pluripotent stem cell differentiation pathway; Hematopoietic stem cell differentiation; Endoderm differentiation; Gene regulatory network modeling somitogenesis ; NOTCH1 regulation of endothelial cell calcification; Pathways affected in adenoid cystic carcinoma; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; BMP signaling in eyelid development; OSX and miRNAs in tooth development; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Somitogenesis in the context of spondylocostal dysostosis; Osteoblast differentiation and related diseases; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; DYRK1A involvement regarding cell proliferation in brain development; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Neurogenesis regulation in the olfactory epithelium; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; Cell lineage map for neuronal differentiation; Notch signaling pathway" "Regulation of NFE2L2 gene expression; Formation of paraxial mesoderm; Somitogenesis; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Pre-NOTCH Processing in Golgi; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating tumorigenic genes; NOTCH4 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Defective LFNG causes SCDO3; RUNX3 regulates NOTCH signaling" "53" "0" "1.048" "1.235" "1.284" "1.227" "1.199" "1.305" "1.236" "1.393" "1.035" "89.7" "94.0" "110.8" "115.2" "110.1" "107.6" "117.1" "110.9" "125.0" "92.9" "" "" "" "" "" "" "" "" "" "" "89.7" "79.5" "70.1" "84.0" "90.2" "83.5" "90.3" "95.4" "97.5" "83.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3451849306749892991" "False" "High" "IsMasterProtein" "P49459" "Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2" "0.000" "False" "5.098" "7" "1" "1" "1" "152" "17.3" "5.15" "4.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7319" "ENSG00000077721" "UBE2A" "A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4" "" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.121" "0.988" "1.191" "0.943" "0.810" "1.074" "0.925" "1.027" "1.042" "110.3" "123.7" "109.0" "131.4" "104.1" "89.3" "118.6" "102.1" "113.3" "115.0" "" "" "" "" "" "" "" "" "" "" "110.3" "104.6" "68.9" "95.8" "85.3" "69.4" "91.4" "87.8" "88.4" "103.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635036141062544876" "False" "High" "IsMasterProtein" "P52655" "Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1" "0.000" "False" "5.091" "5" "2" "2" "2" "376" "41.5" "4.55" "5.22" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "2957" "ENSG00000165417" "GTF2A1" "hsa:2957; P52655; Q3KNQ9" "" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "10" "0" "0.929" "1.043" "1.247" "1.109" "1.099" "1.094" "1.191" "0.842" "1.030" "52.7" "48.9" "54.9" "65.6" "58.4" "57.9" "57.6" "62.7" "44.3" "54.3" "" "" "" "" "" "" "" "" "" "" "52.7" "41.4" "34.7" "47.9" "47.8" "44.9" "44.4" "53.9" "34.6" "48.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1829057595259192676" "False" "High" "IsMasterProtein" "Q8ND83" "SLAIN motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SLAIN1 PE=1 SV=3" "0.000" "False" "5.089" "3" "2" "2" "1" "568" "60.6" "7.64" "5.44" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf15301" "122060" "ENSG00000139737" "SLAIN1" "A8K0Z9; B7Z209; hsa:122060; Q5T6P4; Q5T6P7; Q8ND10; Q8ND83; Q96NV0" "" "" "0" "0" "1.107" "0.876" "0.848" "0.988" "1.145" "1.010" "0.953" "0.909" "0.758" "101.3" "112.1" "88.7" "85.9" "100.1" "115.9" "102.3" "96.6" "92.1" "76.8" "" "" "" "" "" "" "" "" "" "" "101.3" "94.8" "56.1" "62.6" "82.0" "90.0" "78.9" "83.0" "71.9" "69.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.000" "False" "5.086" "9" "1" "1" "1" "159" "17.7" "11.66" "4.30" "1" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.005" "1.385" "1.153" "1.098" "1.299" "1.150" "1.127" "1.204" "1.227" "150.8" "151.6" "208.9" "173.9" "165.5" "195.9" "173.4" "169.9" "181.6" "185.1" "" "" "" "" "" "" "" "" "" "" "150.8" "128.3" "132.1" "126.8" "135.6" "152.2" "133.6" "146.1" "141.7" "166.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "5.084" "4" "1" "1" "1" "270" "29.7" "5.10" "3.67" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657566489845177469" "False" "High" "IsMasterProtein" "Q969K3" "E3 ubiquitin-protein ligase RNF34 OS=Homo sapiens OX=9606 GN=RNF34 PE=1 SV=1" "0.000" "False" "5.081" "3" "1" "1" "1" "372" "41.6" "4.96" "3.51" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13920, Pf21272" "80196" "ENSG00000170633" "RNF34" "B7Z933; hsa:80196; Q8NG47; Q969K3; Q9H6W8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TP53 Degradation" "2" "0" "1.035" "0.832" "1.003" "0.927" "0.717" "1.555" "0.820" "0.647" "0.745" "21.6" "22.4" "18.0" "21.7" "20.0" "15.5" "33.6" "17.7" "14.0" "16.1" "" "" "" "" "" "" "" "" "" "" "21.6" "18.9" "11.4" "15.8" "16.4" "12.0" "25.9" "15.2" "10.9" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "5.067" "2" "2" "2" "2" "638" "69.8" "8.95" "5.58" "2" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "" "XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "1.011" "1.374" "1.052" "1.014" "1.128" "1.057" "1.117" "1.361" "1.208" "80.1" "81.0" "110.1" "84.3" "81.3" "90.3" "84.6" "89.5" "109.0" "96.8" "" "" "" "" "" "" "" "" "" "" "80.1" "68.5" "69.6" "61.4" "66.6" "70.2" "65.3" "76.9" "85.1" "87.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.000" "False" "5.067" "1" "1" "1" "1" "1000" "110.4" "5.69" "4.35" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.138" "0.864" "1.103" "0.945" "0.959" "1.036" "1.016" "0.899" "0.906" "68.3" "77.7" "59.0" "75.4" "64.6" "65.5" "70.8" "69.4" "61.4" "61.9" "" "" "" "" "" "" "" "" "" "" "68.3" "65.8" "37.3" "55.0" "52.9" "50.9" "54.5" "59.7" "48.0" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8681135963765944837" "False" "High" "IsMasterProtein" "Q01892" "Transcription factor Spi-B OS=Homo sapiens OX=9606 GN=SPIB PE=1 SV=1" "0.000" "False" "5.065" "5" "1" "1" "1" "262" "28.8" "5.52" "4.40" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "6689" "ENSG00000269404" "SPIB" "A8K9C9; B4DUG6; hsa:6689; Q01892; Q15359" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2309309010695254198" "False" "High" "IsMasterProtein" "Q7Z6J8" "E3 ubiquitin-protein ligase E3D OS=Homo sapiens OX=9606 GN=UBE3D PE=1 SV=2" "0.000" "False" "5.060" "4" "1" "1" "1" "389" "43.6" "8.13" "4.30" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09814" "90025" "ENSG00000118420" "UBE3D" "B4DP63; hsa:90025; Q5T4W2; Q6IPR4; Q75UG0; Q7Z6J8; Q9NT42" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "5.051" "2" "1" "2" "1" "418" "45.9" "6.46" "4.14" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "0.891" "0.881" "1.004" "0.849" "0.972" "0.949" "0.962" "0.880" "0.861" "180.5" "160.9" "159.1" "181.2" "153.3" "175.4" "171.3" "173.7" "158.9" "155.4" "" "" "" "" "" "" "" "" "" "" "180.5" "136.1" "100.6" "132.1" "125.6" "136.2" "132.1" "149.3" "124.0" "139.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.000" "False" "5.050" "1" "2" "2" "2" "2442" "281.0" "5.02" "5.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Mesodermal commitment pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.038" "1.097" "1.122" "1.194" "1.153" "1.106" "1.307" "1.026" "1.183" "138.7" "143.9" "152.1" "155.6" "165.5" "159.9" "153.3" "181.2" "142.2" "164.0" "" "" "" "" "" "" "" "" "" "" "138.7" "121.8" "96.2" "113.5" "135.6" "124.1" "118.2" "155.8" "111.0" "147.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "5.039" "8" "2" "2" "2" "268" "28.1" "8.27" "2.96" "2" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "Gastric cancer network 1" "" "1" "0" "1.005" "1.049" "0.805" "1.001" "1.069" "0.891" "0.945" "0.958" "0.904" "52.0" "52.3" "54.6" "41.9" "52.1" "55.6" "46.3" "49.1" "49.8" "47.0" "" "" "" "" "" "" "" "" "" "" "52.0" "44.2" "34.5" "30.5" "42.6" "43.2" "35.7" "42.2" "38.9" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2261169505387302822" "False" "High" "IsMasterProtein" "Q2M1Z3" "Rho GTPase-activating protein 31 OS=Homo sapiens OX=9606 GN=ARHGAP31 PE=1 SV=2" "0.000" "False" "5.037" "1" "2" "2" "1" "1444" "156.9" "5.76" "5.51" "2" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "57514" "ENSG00000031081" "ARHGAP31" "hsa:57514; Q2M1Z3; Q9ULL6" "Genetic causes of porto-sinusoidal vascular disease" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.000" "False" "5.035" "5" "1" "1" "1" "185" "18.8" "4.75" "3.42" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "2" "0" "0.992" "0.924" "0.972" "0.839" "1.099" "1.209" "0.902" "1.186" "1.098" "41.1" "40.7" "37.9" "39.9" "34.4" "45.1" "49.6" "37.0" "48.7" "45.1" "" "" "" "" "" "" "" "" "" "" "41.1" "34.5" "24.0" "29.1" "28.2" "35.0" "38.3" "31.8" "38.0" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8164709769345228762" "False" "High" "IsMasterProtein" "Q9H4Z3" "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1" "0.000" "False" "5.033" "2" "1" "1" "1" "704" "80.6" "7.42" "3.06" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf12237" "63935" "ENSG00000100982" "PCIF1" "E1P5P1; hsa:63935; Q54AB9; Q9H4Z3; Q9NT85" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "5.032" "5" "2" "3" "2" "323" "36.8" "8.24" "5.33" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.000" "False" "5.027" "10" "1" "1" "1" "97" "10.8" "4.36" "4.26" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "0.950" "0.878" "1.013" "0.999" "0.938" "1.039" "1.051" "0.827" "1.017" "232.7" "221.0" "204.3" "235.7" "232.6" "218.4" "241.8" "244.6" "192.5" "236.7" "" "" "" "" "" "" "" "" "" "" "232.7" "187.0" "129.2" "171.8" "190.5" "169.6" "186.4" "210.3" "150.3" "212.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981502460717336485" "False" "High" "IsMasterProtein" "O60244" "Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2" "0.000" "False" "5.026" "1" "2" "2" "1" "1454" "160.5" "8.73" "5.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08638" "9282" "ENSG00000180182" "MED14" "hsa:9282; O60244; Q4KMR7; Q9UNB3" "Vitamin D in inflammatory diseases" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "5" "0" "1.048" "0.852" "0.972" "1.183" "1.117" "1.114" "1.078" "0.978" "1.121" "69.2" "72.5" "58.9" "67.2" "81.8" "77.3" "77.0" "74.6" "67.7" "77.5" "" "" "" "" "" "" "" "" "" "" "69.2" "61.3" "37.2" "49.0" "67.0" "60.0" "59.4" "64.1" "52.8" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.000" "False" "5.022" "6" "1" "2" "1" "178" "20.0" "7.56" "7.73" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7546150518504420539" "False" "High" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "0.000" "False" "5.020" "2" "1" "1" "1" "592" "67.7" "7.80" "3.71" "1" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "3" "0" "0.925" "0.940" "1.170" "1.021" "1.175" "1.210" "1.031" "1.114" "1.154" "102.4" "94.7" "96.2" "119.8" "104.6" "120.3" "123.8" "105.5" "114.1" "118.1" "" "" "" "" "" "" "" "" "" "" "102.4" "80.1" "60.8" "87.3" "85.7" "93.4" "95.5" "90.7" "89.0" "106.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "5.020" "2" "2" "2" "2" "1085" "110.0" "9.94" "5.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "0.997" "1.074" "1.138" "1.272" "1.222" "1.116" "1.152" "1.029" "1.049" "72.8" "72.5" "78.2" "82.8" "92.6" "88.9" "81.2" "83.8" "74.9" "76.3" "" "" "" "" "" "" "" "" "" "" "72.8" "61.3" "49.4" "60.4" "75.8" "69.1" "62.6" "72.1" "58.4" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7084160994910384820" "False" "High" "IsMasterProtein" "Q96G04" "Protein-lysine N-methyltransferase EEF2KMT OS=Homo sapiens OX=9606 GN=EEF2KMT PE=1 SV=2" "0.000" "False" "5.012" "3" "1" "1" "1" "330" "36.9" "6.05" "3.41" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf10294, Pf14904" "196483" "ENSG00000118894" "EEF2KMT" "D3DUF0; Q96G04; Q96S85" "" "Protein methylation" "1" "0" "1.093" "0.996" "1.045" "0.914" "0.981" "1.098" "1.058" "1.097" "1.045" "90.0" "98.4" "89.7" "94.1" "82.3" "88.3" "98.8" "95.2" "98.8" "94.1" "" "" "" "" "" "" "" "" "" "" "90.0" "83.3" "56.7" "68.6" "67.4" "68.6" "76.2" "81.9" "77.1" "84.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378421800270237029" "False" "High" "IsMasterProtein" "Q5TZA2" "Rootletin OS=Homo sapiens OX=9606 GN=CROCC PE=1 SV=2" "0.000" "False" "4.997" "1" "2" "3" "1" "2017" "228.3" "5.49" "6.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf15035" "9696" "ENSG00000058453" "CROCC" "hsa:9696; Q2VHY3; Q5TZA2; Q66GT7; Q7Z2L4; Q7Z5D7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4738177424081249956" "False" "High" "IsMasterProtein" "Q8WWI1" "LIM domain only protein 7 OS=Homo sapiens OX=9606 GN=LMO7 PE=1 SV=3" "0.000" "False" "4.996" "1" "1" "1" "1" "1683" "192.6" "8.09" "3.67" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00307, Pf00412, Pf00595, Pf15949" "4008" "ENSG00000136153" "LMO7" "E9PLH4; O15462; O95346; Q5TBK6; Q8WWI1; Q9UKC1; Q9UQM5; Q9Y6A7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Signaling by ALK fusions and activated point mutants" "3" "0" "1.277" "1.571" "1.444" "1.137" "1.854" "1.184" "1.049" "1.509" "1.452" "33.0" "42.1" "51.8" "47.6" "37.5" "61.1" "39.0" "34.6" "49.7" "47.9" "" "" "" "" "" "" "" "" "" "" "33.0" "35.6" "32.7" "34.7" "30.7" "47.5" "30.1" "29.7" "38.8" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1198198230857353565" "False" "High" "IsMasterProtein" "O43169" "Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3" "0.000" "False" "4.996" "8" "1" "1" "1" "150" "16.7" "4.97" "2.79" "1" "other metabolic processes;stress response" "other membranes;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00173" "80777" "ENSG00000103018" "CYB5B" "A8K6B1; hsa:80777; J3KNF8; O43169; Q96CC3; Q9BT35" "Oxidation by cytochrome P450" "Sphingolipid de novo biosynthesis; Phase I - Functionalization of compounds" "3" "0" "1.114" "1.042" "0.876" "1.311" "1.031" "1.250" "1.289" "1.309" "1.159" "18.0" "20.1" "18.8" "15.8" "23.6" "18.6" "22.6" "23.3" "23.6" "20.9" "" "" "" "" "" "" "" "" "" "" "18.0" "17.0" "11.9" "11.5" "19.4" "14.5" "17.4" "20.0" "18.4" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3918971924664803467" "False" "High" "IsMasterProtein" "Q14088" "Ras-related protein Rab-33A OS=Homo sapiens OX=9606 GN=RAB33A PE=1 SV=2" "0.000" "False" "4.985" "7" "2" "2" "2" "237" "26.6" "7.88" "3.27" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "9363" "ENSG00000134594" "RAB33A" "hsa:9363; Q14088; Q5JUZ6; Q92465" "" "RAB geranylgeranylation; TBC/RABGAPs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.000" "False" "4.983" "10" "1" "1" "1" "121" "13.8" "7.31" "4.44" "1" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "1.117" "0.910" "1.013" "1.116" "1.120" "1.068" "1.189" "0.891" "1.075" "53.8" "60.1" "49.0" "54.6" "60.1" "60.3" "57.5" "64.0" "48.0" "57.9" "" "" "" "" "" "" "" "" "" "" "53.8" "50.9" "31.0" "39.8" "49.2" "46.8" "44.3" "55.1" "37.5" "52.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045891090085866349" "False" "High" "IsMasterProtein" "Q6N063" "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OGFOD2 PE=1 SV=2" "0.000" "False" "4.978" "5" "2" "2" "2" "350" "39.0" "5.68" "6.01" "2" "" "" "other molecular function" "" "79676" "ENSG00000111325" "OGFOD2" "B3KT24; hsa:79676; Q4KN13; Q6N023; Q6N063; Q9H8K6" "" "" "0" "0" "0.927" "1.019" "1.059" "1.078" "0.988" "1.061" "1.101" "0.949" "0.946" "146.7" "136.0" "149.4" "155.3" "158.0" "144.9" "155.6" "161.5" "139.2" "138.7" "" "" "" "" "" "" "" "" "" "" "146.7" "115.1" "94.5" "113.2" "129.5" "112.6" "119.9" "138.8" "108.7" "124.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "4.968" "2" "2" "2" "1" "759" "84.5" "7.23" "4.51" "2" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "Integrin-mediated cell adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "1.065" "1.214" "1.063" "1.010" "1.032" "0.944" "0.900" "1.110" "1.021" "218.1" "232.3" "264.9" "231.9" "220.2" "225.1" "206.0" "196.2" "242.2" "222.8" "" "" "" "" "" "" "" "" "" "" "218.1" "196.5" "167.5" "169.1" "180.4" "174.8" "158.8" "168.7" "189.1" "200.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.000" "False" "4.968" "5" "1" "3" "1" "206" "23.0" "5.24" "7.93" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "673060285531934523" "False" "High" "IsMasterProtein" "Q8IWF6" "Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1" "0.000" "False" "4.965" "2" "1" "1" "1" "608" "69.5" "8.27" "4.57" "1" "other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf09794" "201627" "ENSG00000174839" "DENND6A" "hsa:201627; Q7Z5T4; Q8IWF6; Q8N235; Q8TEG8" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "4.959" "3" "1" "1" "1" "391" "42.5" "5.66" "4.30" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress" "14" "0" "0.609" "0.747" "1.542" "0.878" "0.986" "1.061" "0.402" "1.756" "1.266" "98.1" "59.8" "73.3" "151.2" "86.1" "96.8" "104.1" "39.4" "172.3" "124.2" "" "" "" "" "" "" "" "" "" "" "98.1" "50.6" "46.4" "110.3" "70.5" "75.1" "80.3" "33.9" "134.5" "111.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "4.949" "35" "3" "4" "3" "85" "9.1" "9.31" "7.72" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "1.083" "1.211" "1.129" "1.003" "1.126" "1.229" "0.953" "1.088" "0.990" "233.1" "252.3" "282.2" "263.2" "233.8" "262.4" "286.4" "222.1" "253.5" "230.7" "" "" "" "" "" "" "" "" "" "" "233.1" "213.5" "178.5" "191.9" "191.6" "203.8" "220.7" "190.9" "197.9" "207.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2150748430854839914" "False" "High" "IsMasterProtein" "Q96JC1" "Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2" "0.000" "False" "4.948" "3" "2" "2" "2" "886" "101.7" "6.99" "5.27" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00780, Pf10366, Pf10367" "23339" "ENSG00000166887" "VPS39" "hsa:23339; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96JC1; Q96RM0" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "4" "0" "1.163" "1.047" "0.887" "1.215" "1.006" "1.030" "1.230" "1.065" "1.033" "28.7" "33.3" "30.0" "25.4" "34.8" "28.8" "29.5" "35.2" "30.5" "29.6" "" "" "" "" "" "" "" "" "" "" "28.7" "28.2" "19.0" "18.5" "28.5" "22.4" "22.8" "30.3" "23.8" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "4.945" "4" "2" "3" "2" "575" "63.5" "7.03" "7.17" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "4.940" "9" "2" "2" "2" "184" "19.4" "5.83" "6.38" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.000" "False" "4.935" "7" "2" "2" "2" "243" "27.0" "9.16" "5.76" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "1.094" "1.222" "1.175" "1.046" "1.372" "1.205" "1.136" "1.365" "1.141" "54.9" "60.0" "67.1" "64.5" "57.4" "75.3" "66.2" "62.4" "74.9" "62.6" "" "" "" "" "" "" "" "" "" "" "54.9" "50.8" "42.4" "47.0" "47.0" "58.5" "51.0" "53.6" "58.5" "56.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6065007746744177820" "False" "High" "IsMasterProtein" "Q9ULZ2" "Signal-transducing adaptor protein 1 OS=Homo sapiens OX=9606 GN=STAP1 PE=1 SV=1" "0.000" "False" "4.926" "4" "1" "1" "1" "295" "34.3" "7.77" "3.47" "1" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00169" "26228" "ENSG00000035720" "STAP1" "B2R980; hsa:26228; Q9ULZ2" "" "" "0" "0" "0.817" "1.064" "1.091" "1.118" "1.129" "1.209" "0.857" "1.205" "0.979" "28.2" "23.1" "30.1" "30.8" "31.6" "31.9" "34.2" "24.2" "34.0" "27.7" "" "" "" "" "" "" "" "" "" "" "28.2" "19.5" "19.0" "22.5" "25.9" "24.8" "26.3" "20.8" "26.6" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6806341616060295731" "False" "High" "IsMasterProtein" "Q8WYL5" "Protein phosphatase Slingshot homolog 1 OS=Homo sapiens OX=9606 GN=SSH1 PE=1 SV=2" "0.000" "False" "4.920" "2" "2" "2" "2" "1049" "115.4" "6.25" "6.04" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00782, Pf08766" "54434" "ENSG00000084112" "SSH1" "hsa:54434; Q6P6C0; Q8N9A7; Q8WYL3; Q8WYL4; Q8WYL5; Q9P2P8" "Regulation of actin cytoskeleton" "" "1" "0" "1.075" "1.119" "1.105" "1.066" "1.156" "1.131" "1.072" "1.218" "1.144" "134.9" "145.0" "150.9" "149.1" "143.8" "156.0" "152.6" "144.7" "164.2" "154.4" "" "" "" "" "" "" "" "" "" "" "134.9" "122.7" "95.4" "108.7" "117.8" "121.1" "117.6" "124.4" "128.2" "138.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4527402495997135849" "False" "High" "IsMasterProtein" "Q08AG7" "Mitotic-spindle organizing protein 1 OS=Homo sapiens OX=9606 GN=MZT1 PE=1 SV=2" "0.000" "False" "4.912" "20" "1" "1" "1" "82" "8.5" "4.78" "3.98" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf12554" "440145" "ENSG00000204899" "MZT1" "hsa:440145; Q08AG7; Q5W0P5" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "4.898" "3" "2" "2" "2" "583" "66.2" "8.18" "4.17" "2" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "Influence of laminopathies on Wnt signaling" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1352490875980109709" "False" "High" "IsMasterProtein" "Q5VVQ6" "Ubiquitin thioesterase OTU1 OS=Homo sapiens OX=9606 GN=YOD1 PE=1 SV=1" "0.000" "False" "4.892" "5" "2" "2" "2" "348" "38.3" "6.11" "5.41" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02338, Pf21403" "55432" "ENSG00000180667" "YOD1" "B2RNX3; hsa:55432; Q5VVQ5; Q5VVQ6; Q6ZRS6; Q86T63; Q9P1L8" "" "Ovarian tumor domain proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7148094604996287167" "False" "High" "IsMasterProtein" "Q9Y3E1" "Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1" "0.000" "False" "4.889" "8" "2" "3" "1" "203" "22.6" "7.99" "9.16" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00855" "50810" "ENSG00000166503" "HDGFL3" "hsa:50810; Q9Y3E1" "" "" "0" "0" "0.921" "0.987" "1.009" "1.018" "1.021" "1.075" "0.876" "1.150" "0.939" "151.9" "139.9" "150.0" "153.3" "154.6" "155.2" "163.4" "133.1" "174.6" "142.7" "" "" "" "" "" "" "" "" "" "" "151.9" "118.4" "94.9" "111.8" "126.7" "120.5" "125.9" "114.4" "136.3" "128.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "High" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.000" "False" "4.884" "2" "1" "1" "1" "462" "48.8" "9.69" "3.21" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.978" "0.725" "0.881" "0.988" "0.756" "0.996" "0.903" "0.827" "0.872" "74.0" "72.4" "53.6" "65.2" "73.1" "56.0" "73.7" "66.8" "61.2" "64.5" "" "" "" "" "" "" "" "" "" "" "74.0" "61.2" "33.9" "47.6" "59.9" "43.5" "56.8" "57.5" "47.8" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7272269523816723745" "False" "High" "IsMasterProtein" "Q13613" "Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4" "0.000" "False" "4.876" "3" "2" "2" "2" "665" "74.6" "7.14" "6.54" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf02893, Pf06602" "8776" "ENSG00000063601" "MTMR1" "A0A024RC07; hsa:8776; Q13613; Q9UBX6; Q9UEM0; Q9UQD5" "" "RHOF GTPase cycle; Synthesis of PIPs at the plasma membrane" "2" "0" "1.016" "1.077" "1.009" "0.900" "1.075" "0.875" "1.103" "1.033" "1.077" "86.2" "87.6" "92.8" "86.9" "77.6" "92.7" "75.4" "95.1" "89.0" "92.8" "" "" "" "" "" "" "" "" "" "" "86.2" "74.1" "58.7" "63.4" "63.5" "72.0" "58.1" "81.7" "69.5" "83.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7026483087037268354" "False" "High" "IsMasterProtein" "Q05823" "2-5A-dependent ribonuclease OS=Homo sapiens OX=9606 GN=RNASEL PE=1 SV=2" "0.000" "False" "4.874" "2" "2" "3" "1" "741" "83.5" "6.65" "6.14" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00023, Pf00069, Pf06479" "6041" "ENSG00000135828" "RNASEL" "hsa:6041; Q05823; Q5W0L2; Q6AI46" "" "Interferon alpha/beta signaling; OAS antiviral response" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.000" "False" "4.869" "2" "1" "1" "1" "445" "52.6" "5.62" "4.07" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "5q35 copy number variation" "Neutrophil degranulation; RHOA GTPase cycle" "3" "0" "0.897" "0.888" "0.865" "1.109" "0.894" "1.017" "0.975" "0.854" "0.919" "78.4" "70.3" "69.6" "67.7" "86.9" "70.1" "79.7" "76.4" "66.9" "72.0" "" "" "" "" "" "" "" "" "" "" "78.4" "59.5" "44.0" "49.4" "71.2" "54.4" "61.4" "65.7" "52.2" "64.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "4.860" "3" "1" "1" "1" "289" "32.8" "7.09" "3.70" "1" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.290" "1.299" "1.054" "1.214" "1.180" "1.130" "1.164" "1.169" "1.255" "128.3" "165.5" "166.6" "135.2" "155.7" "151.4" "145.0" "149.3" "149.9" "161.0" "" "" "" "" "" "" "" "" "" "" "128.3" "140.1" "105.4" "98.6" "127.6" "117.6" "111.7" "128.4" "117.0" "144.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "4.858" "6" "1" "2" "1" "142" "16.0" "4.31" "5.96" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "" "Mitochondrial protein import" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "High" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.000" "False" "4.848" "1" "2" "2" "2" "1905" "214.7" "7.40" "4.26" "2" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981490796003058050" "False" "High" "IsMasterProtein" "Q9H4P4" "E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2" "0.000" "False" "4.843" "3" "1" "1" "1" "317" "35.9" "6.14" "3.54" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08941, Pf13923" "10193" "ENSG00000181852" "RNF41" "A6NFW0; B2RBT8; hsa:10193; O75598; Q9H4P4" "" "Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling" "2" "0" "1.010" "1.079" "1.219" "0.844" "0.896" "0.951" "0.990" "1.054" "0.877" "43.8" "44.3" "47.3" "53.4" "37.0" "39.2" "41.7" "43.3" "46.2" "38.4" "" "" "" "" "" "" "" "" "" "" "43.8" "37.4" "29.9" "38.9" "30.3" "30.5" "32.1" "37.3" "36.0" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "4.841" "4" "2" "2" "2" "474" "53.3" "5.52" "4.50" "2" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "0.619" "0.621" "0.712" "0.582" "0.955" "0.556" "0.531" "0.857" "0.787" "23.8" "14.7" "14.8" "17.0" "13.9" "22.8" "13.3" "12.7" "20.4" "18.8" "" "" "" "" "" "" "" "" "" "" "23.8" "12.5" "9.4" "12.4" "11.4" "17.7" "10.2" "10.9" "16.0" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7958389170144649522" "False" "High" "IsMasterProtein" "P45983" "Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2" "0.000" "False" "4.839" "4" "2" "2" "1" "427" "48.3" "6.89" "6.39" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5599" "ENSG00000107643" "MAPK8" "B5BTZ5; B7ZLV4; D3DX88; D3DX92; hsa:5599; P45983; Q15709; Q15712; Q15713; Q308M2" "Osteoclast signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; IL-3 signaling pathway; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; PDGFR-beta pathway; Wnt signaling in kidney disease; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; Wnt signaling; miRNA role in immune response in sepsis; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Roles of ceramides in development of insulin resistance; IL-26 signaling pathways; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Signaling by ALK fusions and activated point mutants; NRAGE signals death through JNK; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; WNT5:FZD7-mediated leishmania damping; DSCAM interactions; Activation of BIM and translocation to mitochondria ; Activation of the AP-1 family of transcription factors; NRIF signals cell death from the nucleus; Activation of BMF and translocation to mitochondria; Interleukin-38 signaling" "99" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "4.829" "7" "1" "1" "1" "226" "25.5" "8.41" "2.52" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Glutathione conjugation" "3" "0" "1.118" "1.481" "1.418" "1.096" "1.021" "1.008" "1.230" "1.002" "0.737" "15.1" "16.9" "22.3" "21.4" "16.5" "15.4" "15.2" "18.5" "15.1" "11.1" "" "" "" "" "" "" "" "" "" "" "15.1" "14.3" "14.1" "15.6" "13.5" "12.0" "11.7" "15.9" "11.8" "10.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "4.825" "5" "1" "1" "1" "239" "27.5" "8.29" "3.32" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5727120310183573784" "False" "High" "IsMasterProtein" "Q92560" "Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2" "0.000" "False" "4.824" "2" "1" "1" "1" "729" "80.3" "6.84" "4.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01088, Pf18031" "8314" "ENSG00000163930" "BAP1" "A8K993; hsa:8314; Q6LEM0; Q7Z5E8; Q92560" "Clear cell renal cell carcinoma pathways; Pleural mesothelioma; Kleefstra syndrome" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "4.822" "7" "2" "2" "2" "227" "26.1" "8.28" "5.65" "2" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "" "Mitochondrial protein import; Cristae formation" "2" "0" "1.031" "0.936" "1.084" "0.987" "1.103" "1.126" "1.012" "0.905" "1.095" "95.7" "98.6" "89.5" "103.7" "94.4" "105.5" "107.7" "96.8" "86.5" "104.7" "" "" "" "" "" "" "" "" "" "" "95.7" "83.5" "56.6" "75.6" "77.3" "81.9" "83.0" "83.2" "67.6" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928347610324358029" "False" "High" "IsMasterProtein" "Q9HAP6" "Protein lin-7 homolog B OS=Homo sapiens OX=9606 GN=LIN7B PE=1 SV=1" "0.000" "False" "4.818" "5" "1" "1" "1" "207" "22.9" "8.66" "3.60" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00595, Pf02828" "64130" "ENSG00000104863" "LIN7B" "hsa:64130; Q9HAP6" "" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; RHO GTPases Activate Rhotekin and Rhophilins" "4" "0" "0.795" "1.219" "0.890" "0.853" "1.029" "1.074" "0.904" "0.976" "0.915" "117.2" "93.2" "142.9" "104.4" "100.1" "120.7" "125.9" "105.9" "114.5" "107.3" "" "" "" "" "" "" "" "" "" "" "117.2" "78.8" "90.3" "76.1" "82.0" "93.7" "97.0" "91.1" "89.3" "96.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812439539275377351" "False" "High" "IsMasterProtein" "Q9NQ86" "E3 ubiquitin-protein ligase TRIM36 OS=Homo sapiens OX=9606 GN=TRIM36 PE=1 SV=2" "0.000" "False" "4.812" "4" "3" "4" "3" "728" "83.0" "6.11" "8.96" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00041, Pf00643, Pf13445, Pf18568" "55521" "ENSG00000152503" "TRIM36" "A1L3Z1; A6NDD0; B7Z3V4; B7ZAV7; E9PFI8; hsa:55521; Q0P5Z9; Q9NQ86" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.093" "1.053" "1.045" "0.886" "0.860" "0.966" "0.996" "1.068" "1.115" "55.2" "60.3" "58.1" "57.7" "48.9" "47.5" "53.3" "55.0" "59.0" "61.6" "" "" "" "" "" "" "" "" "" "" "55.2" "51.0" "36.7" "42.1" "40.1" "36.9" "41.1" "47.3" "46.0" "55.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2593700082527683985" "False" "High" "IsMasterProtein" "O43572" "A-kinase anchor protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP10 PE=1 SV=2" "0.000" "False" "4.809" "3" "2" "2" "2" "662" "73.8" "6.39" "6.43" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00615" "11216" "ENSG00000108599" "AKAP10" "B2R650; hsa:11216; O43572; Q96AJ7" "G protein signaling pathways; TAR syndrome" "Factors involved in megakaryocyte development and platelet production" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5249923035871806906" "False" "High" "IsMasterProtein" "O60759" "Cytohesin-interacting protein OS=Homo sapiens OX=9606 GN=CYTIP PE=1 SV=2" "0.000" "False" "4.808" "4" "2" "2" "2" "359" "40.0" "6.99" "5.65" "2" "other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00595" "9595" "ENSG00000115165" "CYTIP" "B4DWH9; hsa:9595; O60759; Q15630; Q8NE32" "Amplification and expansion of oncogenic pathways as metastatic traits" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8150388100330610211" "False" "High" "IsMasterProtein" "Q96HP0" "Dedicator of cytokinesis protein 6 OS=Homo sapiens OX=9606 GN=DOCK6 PE=1 SV=3" "0.000" "False" "4.802" "1" "2" "2" "1" "2047" "229.4" "6.74" "6.49" "2" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "57572" "ENSG00000130158" "DOCK6" "A6H8X5; hsa:57572; Q7Z7P4; Q96HP0; Q9P2F2" "Genetic causes of porto-sinusoidal vascular disease" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "4" "0" "1.074" "0.952" "1.139" "0.968" "0.904" "1.137" "1.071" "0.955" "0.883" "120.2" "129.1" "114.4" "136.9" "116.3" "108.7" "136.7" "128.7" "114.7" "106.1" "" "" "" "" "" "" "" "" "" "" "120.2" "109.2" "72.4" "99.8" "95.3" "84.4" "105.4" "110.6" "89.6" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6981567354116466271" "False" "High" "IsMasterProtein" "O43542" "DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1" "0.000" "False" "4.799" "3" "1" "1" "1" "346" "37.8" "8.48" "3.41" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7517" "ENSG00000126215" "XRCC3" "hsa:7517; O43542; O43568; Q9BU18" "Fluoropyrimidine activity; Male infertility" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8040183580905194760" "False" "High" "IsMasterProtein" "Q8TC26" "Transmembrane protein 163 OS=Homo sapiens OX=9606 GN=TMEM163 PE=1 SV=1" "0.000" "False" "4.798" "6" "2" "2" "2" "289" "31.4" "7.53" "5.91" "2" "transport;developmental processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "81615" "ENSG00000152128" "TMEM163" "hsa:81615; Q53QM3; Q53SV7; Q69YH3; Q8TC26; Q9UFG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3898709646125856874" "False" "High" "IsMasterProtein" "Q02086" "Transcription factor Sp2 OS=Homo sapiens OX=9606 GN=SP2 PE=1 SV=3" "0.000" "False" "4.797" "2" "1" "1" "1" "613" "64.9" "9.92" "4.12" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6668" "ENSG00000167182" "SP2" "A6NK74; hsa:6668; Q02086" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.000" "False" "4.790" "2" "1" "1" "1" "657" "74.9" "7.83" "3.65" "1" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "High" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.000" "False" "4.790" "1" "1" "1" "1" "1143" "130.9" "6.87" "3.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Mesodermal commitment pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.049" "0.713" "1.108" "0.871" "0.850" "1.073" "1.175" "0.777" "0.921" "38.5" "40.4" "27.5" "42.7" "33.6" "32.7" "41.4" "45.3" "29.9" "35.5" "" "" "" "" "" "" "" "" "" "" "38.5" "34.2" "17.4" "31.1" "27.5" "25.4" "31.9" "38.9" "23.4" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7498924071980765815" "False" "High" "IsMasterProtein" "Q9Y2G3" "Phospholipid-transporting ATPase IF OS=Homo sapiens OX=9606 GN=ATP11B PE=1 SV=2" "0.000" "False" "4.787" "1" "1" "1" "1" "1177" "134.1" "6.96" "3.54" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00702, Pf13246, Pf16209, Pf16212" "23200" "ENSG00000058063" "ATP11B" "hsa:23200; Q96FN1; Q9UKK7; Q9Y2G3" "" "Neutrophil degranulation; Ion transport by P-type ATPases" "2" "0" "1.219" "0.900" "1.162" "1.424" "1.321" "1.363" "1.360" "1.018" "1.130" "29.5" "36.0" "26.6" "34.3" "42.1" "39.0" "40.3" "40.2" "30.1" "33.4" "" "" "" "" "" "" "" "" "" "" "29.5" "30.5" "16.8" "25.0" "34.5" "30.3" "31.0" "34.5" "23.5" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330094663577244460" "False" "High" "IsMasterProtein" "Q13049" "E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2" "0.000" "False" "4.784" "2" "1" "1" "1" "653" "71.9" "6.98" "3.12" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01436, Pf13445" "22954" "ENSG00000119401" "TRIM32" "hsa:22954; Q13049; Q9NQP8" "Ciliopathies; Bardet-Biedl syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "4.780" "7" "1" "1" "1" "237" "26.4" "10.86" "3.05" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.209" "1.164" "1.271" "1.097" "1.309" "1.132" "1.371" "1.428" "1.103" "33.0" "39.9" "38.4" "42.0" "36.2" "43.2" "37.4" "45.3" "47.1" "36.4" "" "" "" "" "" "" "" "" "" "" "33.0" "33.8" "24.3" "30.6" "29.7" "33.6" "28.8" "38.9" "36.8" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "High" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.000" "False" "4.778" "5" "2" "2" "1" "302" "34.5" "8.25" "4.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "5" "0" "1.025" "0.956" "0.915" "1.034" "0.970" "0.978" "1.000" "0.950" "1.005" "221.3" "226.8" "211.5" "202.5" "228.8" "214.7" "216.6" "221.2" "210.2" "222.4" "" "" "" "" "" "" "" "" "" "" "221.3" "191.9" "133.7" "147.7" "187.4" "166.8" "166.9" "190.2" "164.0" "200.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.000" "False" "4.768" "1" "2" "3" "2" "1215" "131.3" "5.30" "5.40" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Cilium Assembly; Aggrephagy; Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "17" "0" "1.282" "0.932" "0.960" "1.016" "1.051" "0.859" "1.046" "1.076" "1.143" "100.8" "129.1" "93.9" "96.7" "102.3" "105.9" "86.6" "105.4" "108.4" "115.2" "" "" "" "" "" "" "" "" "" "" "100.8" "109.3" "59.4" "70.5" "83.9" "82.2" "66.7" "90.6" "84.6" "103.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.000" "False" "4.766" "2" "1" "1" "1" "614" "67.1" "8.92" "3.72" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "4.758" "5" "1" "1" "1" "243" "27.2" "7.30" "2.66" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Ciliary landscape" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Sphingolipid de novo biosynthesis; RAC2 GTPase cycle; RHOD GTPase cycle" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5444198170657218689" "False" "High" "IsMasterProtein" "O14508" "Suppressor of cytokine signaling 2 OS=Homo sapiens OX=9606 GN=SOCS2 PE=1 SV=1" "0.000" "False" "4.750" "8" "2" "2" "2" "198" "22.2" "8.69" "5.89" "2" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf07525" "8835" "ENSG00000120833" "SOCS2" "A8K3D1; hsa:8835; O14508; O14542; O95102; Q9UKS5" "Leptin signaling pathway; Prolactin signaling pathway; Ectoderm differentiation; Leptin-insulin signaling overlap; JAK-STAT signaling in the regulation of beta cells" "Neddylation; Interleukin-7 signaling; Negative regulation of FLT3; Growth hormone receptor signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4045203445570515749" "False" "High" "IsMasterProtein" "Q9BQ49" "Small integral membrane protein 7 OS=Homo sapiens OX=9606 GN=SMIM7 PE=1 SV=2" "0.000" "False" "4.749" "13" "1" "1" "1" "75" "8.6" "8.18" "3.58" "1" "" "other membranes" "" "" "79086" "ENSG00000214046" "SMIM7" "A8MX44; hsa:79086; Q9BQ49" "" "" "0" "0" "1.061" "0.909" "0.977" "0.875" "1.105" "1.190" "1.036" "0.778" "0.973" "73.5" "78.0" "66.8" "71.9" "64.3" "81.2" "87.5" "76.2" "57.2" "71.5" "" "" "" "" "" "" "" "" "" "" "73.5" "66.0" "42.3" "52.4" "52.7" "63.1" "67.4" "65.5" "44.6" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "4.748" "1" "2" "2" "1" "1417" "158.9" "7.49" "5.98" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "18" "0" "1.180" "1.196" "1.400" "1.138" "1.354" "1.125" "1.196" "1.268" "1.051" "70.3" "83.0" "84.1" "98.4" "80.0" "95.2" "79.1" "84.1" "89.2" "73.9" "" "" "" "" "" "" "" "" "" "" "70.3" "70.2" "53.2" "71.8" "65.6" "73.9" "61.0" "72.3" "69.6" "66.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004394019571150397" "False" "High" "IsMasterProtein" "P25942" "Tumor necrosis factor receptor superfamily member 5 OS=Homo sapiens OX=9606 GN=CD40 PE=1 SV=1" "0.000" "False" "4.746" "4" "1" "1" "1" "277" "30.6" "5.76" "3.69" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "958" "ENSG00000101017" "CD40" "E1P5S9; hsa:958; P25942; Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0" "Allograft rejection; Complement system; Vitamin D receptor pathway; Nod-like receptor (NLR) signaling pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Platelet-mediated interactions with vascular and circulating cells; Inflammatory response pathway; Genes associated with the development of rheumatoid arthritis; Extrafollicular and follicular B cell activation by SARS-CoV-2; Toll-like receptor signaling pathway" "" "10" "0" "0.649" "0.720" "0.739" "0.843" "0.701" "0.760" "0.797" "0.773" "0.748" "159.5" "103.5" "114.8" "117.8" "134.5" "111.8" "121.2" "127.1" "123.3" "119.4" "" "" "" "" "" "" "" "" "" "" "159.5" "87.6" "72.6" "85.9" "110.2" "86.8" "93.5" "109.3" "96.3" "107.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.000" "False" "4.745" "3" "1" "1" "1" "494" "51.0" "8.16" "4.23" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "Pre-implantation embryo; TYROBP causal network in microglia" "M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.139" "0.985" "1.336" "1.221" "1.322" "1.162" "1.114" "1.155" "1.121" "53.9" "61.3" "53.1" "72.0" "65.8" "71.2" "62.6" "60.0" "62.2" "60.4" "" "" "" "" "" "" "" "" "" "" "53.9" "51.9" "33.6" "52.5" "53.9" "55.3" "48.3" "51.6" "48.6" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858959922113811047" "False" "High" "IsMasterProtein" "Q6ZMI0" "Protein phosphatase 1 regulatory subunit 21 OS=Homo sapiens OX=9606 GN=PPP1R21 PE=1 SV=1" "0.000" "False" "4.737" "2" "1" "1" "1" "780" "88.3" "6.84" "4.07" "1" "" "other cytoplasmic organelle" "" "Pf10205, Pf10212, Pf21636" "129285" "ENSG00000162869" "PPP1R21" "B7ZKY5; B7ZKY7; E1B6W7; hsa:129285; Q2TA78; Q6ZMI0; Q6ZMI6; Q8IW83; Q8J029; Q96ES8" "" "" "0" "0" "0.939" "1.141" "1.124" "1.160" "0.987" "1.232" "0.867" "0.857" "1.026" "49.7" "46.7" "56.8" "55.9" "57.7" "49.1" "61.3" "43.1" "42.6" "51.1" "" "" "" "" "" "" "" "" "" "" "49.7" "39.5" "35.9" "40.8" "47.3" "38.1" "47.3" "37.1" "33.3" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9046713427756662077" "False" "High" "IsMasterProtein" "Q05209" "Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3" "0.000" "False" "4.734" "1" "1" "1" "1" "780" "88.1" "5.62" "3.44" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5782" "ENSG00000127947" "PTPN12" "A4D1C5; B4DKY2; E9PBR5; E9PEH9; hsa:5782; Q05209; Q16130; Q59FD6; Q75MN8; Q86XU4" "EGF/EGFR signaling pathway" "Signaling by PDGF; SHC1 events in ERBB2 signaling; Downregulation of ERBB2 signaling; EGFR downregulation; Interleukin-37 signaling; Constitutive Signaling by Overexpressed ERBB2" "7" "0" "0.920" "0.864" "0.946" "0.908" "1.015" "0.906" "1.047" "0.846" "0.975" "131.8" "121.3" "113.9" "124.7" "119.7" "133.7" "119.5" "138.0" "111.5" "128.5" "" "" "" "" "" "" "" "" "" "" "131.8" "102.6" "72.0" "90.9" "98.1" "103.8" "92.1" "118.6" "87.0" "115.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463196673493200714" "False" "High" "IsMasterProtein" "P01116" "GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1" "0.000" "False" "4.732" "10" "2" "2" "2" "189" "21.6" "6.77" "4.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00071" "3845" "ENSG00000133703" "KRAS" "A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10" "IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF" "60" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "4.730" "4" "2" "3" "1" "699" "80.0" "6.54" "2.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "High" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.000" "False" "4.725" "4" "2" "2" "2" "600" "65.4" "9.16" "6.42" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.062" "0.966" "1.073" "1.108" "1.116" "1.154" "1.001" "1.064" "1.078" "84.6" "89.8" "81.7" "90.7" "93.7" "94.4" "97.6" "84.6" "90.0" "91.1" "" "" "" "" "" "" "" "" "" "" "84.6" "76.0" "51.6" "66.1" "76.7" "73.3" "75.2" "72.8" "70.2" "81.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021851569600186030" "False" "High" "IsMasterProtein" "A2A288" "Probable ribonuclease ZC3H12D OS=Homo sapiens OX=9606 GN=ZC3H12D PE=1 SV=3" "0.000" "False" "4.722" "4" "2" "2" "2" "527" "58.0" "8.68" "5.90" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977, Pf18039" "340152" "ENSG00000178199" "ZC3H12D" "A1L178; A2A288; B2RXF4; B7WNU7; B9ZZP9; B9ZZQ0; hsa:340152; Q6ZRW2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "53418054531759760" "False" "High" "IsMasterProtein" "Q86Y79" "Peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1" "0.000" "False" "4.719" "8" "2" "2" "2" "214" "22.9" "10.56" "4.44" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "" "other molecular function" "Pf01195" "138428" "ENSG00000187024" "PTRH1" "hsa:138428; Q86Y79" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880299812085229449" "False" "High" "IsMasterProtein" "P11049" "Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2" "0.000" "False" "4.710" "3" "1" "1" "1" "281" "31.7" "7.94" "3.85" "1" "" "plasma membrane" "" "Pf00335" "951" "ENSG00000104894" "CD37" "B4DVC1; hsa:951; P11049; Q3KPF9" "TYROBP causal network in microglia" "" "1" "0" "0.811" "0.827" "0.840" "0.912" "0.794" "0.962" "0.975" "0.909" "0.869" "116.1" "94.1" "96.0" "97.5" "105.9" "92.2" "111.7" "113.2" "105.5" "100.9" "" "" "" "" "" "" "" "" "" "" "116.1" "79.7" "60.7" "71.1" "86.7" "71.6" "86.1" "97.3" "82.3" "90.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.000" "False" "4.707" "11" "2" "2" "2" "167" "19.5" "4.74" "5.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "Breast cancer pathway" "" "1" "0" "1.197" "0.705" "0.985" "1.177" "0.938" "1.578" "1.291" "0.665" "0.970" "22.1" "26.5" "15.6" "21.8" "26.1" "20.8" "34.9" "28.6" "14.7" "21.5" "" "" "" "" "" "" "" "" "" "" "22.1" "22.4" "9.9" "15.9" "21.3" "16.1" "26.9" "24.6" "11.5" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574893947770882391" "False" "High" "IsMasterProtein" "P53701" "Holocytochrome c-type synthase OS=Homo sapiens OX=9606 GN=HCCS PE=1 SV=1" "0.000" "False" "4.705" "4" "1" "1" "1" "268" "30.6" "6.68" "3.96" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf01265" "3052" "ENSG00000004961" "HCCS" "B3KUS1; hsa:3052; P53701; Q502X8" "" "" "0" "0" "0.870" "1.230" "1.057" "0.982" "1.349" "1.178" "0.868" "1.088" "1.048" "80.5" "70.0" "99.0" "85.1" "79.0" "108.5" "94.8" "69.8" "87.5" "84.3" "" "" "" "" "" "" "" "" "" "" "80.5" "59.2" "62.6" "62.0" "64.7" "84.3" "73.1" "60.0" "68.3" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "High" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.000" "False" "4.701" "0" "1" "1" "1" "2839" "319.2" "7.39" "3.34" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "14" "0" "1.120" "0.779" "0.971" "0.981" "1.042" "1.026" "1.072" "0.786" "1.046" "72.4" "81.1" "56.5" "70.3" "71.1" "75.5" "74.3" "77.7" "56.9" "75.8" "" "" "" "" "" "" "" "" "" "" "72.4" "68.6" "35.7" "51.3" "58.2" "58.6" "57.3" "66.8" "44.4" "68.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6197247688658885913" "False" "High" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "0.000" "False" "4.700" "2" "2" "2" "2" "723" "82.2" "5.99" "5.10" "2" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129, Pf20655" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.142" "1.037" "1.180" "1.176" "1.077" "0.972" "1.086" "1.097" "1.114" "63.5" "72.5" "65.8" "74.9" "74.6" "68.3" "61.7" "69.0" "69.6" "70.7" "" "" "" "" "" "" "" "" "" "" "63.5" "61.3" "41.6" "54.6" "61.1" "53.1" "47.5" "59.3" "54.4" "63.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.000" "False" "4.699" "3" "2" "2" "2" "549" "63.4" "6.39" "5.91" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "1.132" "1.164" "1.055" "1.183" "1.166" "1.188" "1.308" "1.269" "1.190" "66.4" "75.2" "77.3" "70.1" "78.6" "77.5" "78.9" "86.9" "84.3" "79.0" "" "" "" "" "" "" "" "" "" "" "66.4" "63.6" "48.9" "51.1" "64.4" "60.2" "60.9" "74.7" "65.8" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5583729165405332410" "False" "High" "IsMasterProtein" "Q96AB6" "Protein N-terminal asparagine amidohydrolase OS=Homo sapiens OX=9606 GN=NTAN1 PE=1 SV=3" "0.000" "False" "4.697" "5" "2" "2" "2" "310" "34.7" "6.27" "5.22" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf14736" "123803" "ENSG00000157045; ENSG00000275779" "NTAN1" "hsa:123803; Q7Z4Z0; Q96AB6" "" "" "0" "0" "1.016" "1.267" "1.216" "0.952" "1.077" "1.039" "1.122" "1.066" "1.030" "88.0" "89.5" "111.5" "107.1" "83.8" "94.8" "91.5" "98.8" "93.8" "90.7" "" "" "" "" "" "" "" "" "" "" "88.0" "75.7" "70.5" "78.1" "68.7" "73.7" "70.5" "84.9" "73.2" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3184795118132692170" "False" "High" "IsMasterProtein" "P10636" "Microtubule-associated protein tau OS=Homo sapiens OX=9606 GN=MAPT PE=1 SV=5" "0.000" "False" "4.696" "2" "1" "1" "1" "758" "78.9" "6.71" "3.20" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00418" "4137" "ENSG00000186868; ENSG00000276155; ENSG00000277956" "MAPT" "hsa:4137; P10636; P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3; Q9UMH0; Q9UQ96" "IL-5 signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Copper homeostasis; MAPK signaling pathway; IL-2 signaling pathway; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; HDAC6 interactions in the central nervous system" "Caspase-mediated cleavage of cytoskeletal proteins" "14" "0" "0.858" "1.460" "0.929" "1.049" "1.222" "1.122" "1.016" "1.300" "0.893" "27.1" "23.2" "39.5" "25.1" "28.4" "33.1" "30.4" "27.5" "35.2" "24.2" "" "" "" "" "" "" "" "" "" "" "27.1" "19.6" "25.0" "18.3" "23.2" "25.7" "23.4" "23.6" "27.4" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551510042259004717" "False" "High" "IsMasterProtein" "Q70J99" "Protein unc-13 homolog D OS=Homo sapiens OX=9606 GN=UNC13D PE=1 SV=1" "0.000" "False" "4.694" "1" "1" "1" "1" "1090" "123.2" "6.65" "3.29" "1" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf06292" "201294" "ENSG00000092929" "UNC13D" "B4DWG9; hsa:201294; Q70J99; Q9H7K5" "Deregulation of Rab and Rab effector genes in bladder cancer" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3499966319797164374" "False" "High" "IsMasterProtein" "Q9UKZ1" "CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1" "0.000" "False" "4.693" "2" "1" "1" "1" "510" "55.2" "6.40" "3.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10155" "55571" "ENSG00000158435" "CNOT11" "hsa:55571; Q6P2M9; Q8N681; Q9UKZ1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "High" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.000" "False" "4.693" "2" "1" "1" "1" "488" "55.1" "5.60" "3.66" "1" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964570486467497795" "False" "High" "IsMasterProtein" "Q96NM4" "TOX high mobility group box family member 2 OS=Homo sapiens OX=9606 GN=TOX2 PE=1 SV=2" "0.000" "False" "4.677" "4" "2" "2" "1" "488" "51.6" "6.71" "5.26" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "84969" "ENSG00000124191" "TOX2" "A8K1J1; E1P5X0; G3XAC7; hsa:84969; Q5TE33; Q5TE34; Q5TE35; Q96IC9; Q96NM4; Q9BQN5" "Clear cell renal cell carcinoma pathways" "" "1" "0" "0.761" "1.060" "1.178" "0.977" "0.730" "1.228" "1.072" "0.752" "0.868" "24.0" "18.2" "25.4" "28.2" "23.4" "17.5" "29.4" "25.7" "18.0" "20.8" "" "" "" "" "" "" "" "" "" "" "24.0" "15.4" "16.1" "20.6" "19.2" "13.6" "22.7" "22.1" "14.1" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3462028508883828896" "False" "High" "IsMasterProtein" "O60318" "Germinal-center associated nuclear protein OS=Homo sapiens OX=9606 GN=MCM3AP PE=1 SV=2" "0.000" "False" "4.663" "1" "1" "1" "1" "1980" "218.3" "6.39" "3.43" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03399, Pf16766, Pf16768, Pf16769" "8888" "ENSG00000160294" "MCM3AP" "C9JL56; hsa:8888; O60318; Q2M3C1; Q6PJP6; Q9BSY5; Q9UMT4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "4.659" "4" "2" "2" "2" "580" "64.2" "8.41" "3.03" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "1.089" "1.099" "1.056" "1.017" "1.199" "1.122" "1.147" "1.290" "1.211" "125.7" "136.8" "138.2" "132.7" "127.8" "150.7" "141.0" "144.1" "162.1" "152.1" "" "" "" "" "" "" "" "" "" "" "125.7" "115.8" "87.4" "96.8" "104.7" "117.0" "108.7" "123.9" "126.5" "136.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1020812304193846387" "False" "High" "IsMasterProtein" "Q96ED9" "Protein Hook homolog 2 OS=Homo sapiens OX=9606 GN=HOOK2 PE=1 SV=3" "0.000" "False" "4.656" "2" "2" "2" "2" "719" "83.2" "5.47" "6.18" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "29911" "ENSG00000095066" "HOOK2" "hsa:29911; O60562; Q96ED9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "4.654" "1" "1" "1" "1" "813" "92.6" "7.65" "3.82" "1" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Integrin-mediated cell adhesion" "Degradation of the extracellular matrix" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "4.643" "10" "3" "4" "3" "218" "25.6" "9.98" "10.25" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.138" "0.874" "0.986" "1.139" "0.895" "0.976" "1.066" "1.090" "1.016" "113.3" "128.9" "99.0" "111.7" "129.0" "101.3" "110.6" "120.7" "123.5" "115.1" "" "" "" "" "" "" "" "" "" "" "113.3" "109.0" "62.6" "81.4" "105.7" "78.7" "85.2" "103.8" "96.4" "103.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "4.643" "2" "1" "1" "1" "781" "81.9" "5.26" "4.22" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription factors" "5" "0" "0.861" "0.752" "0.984" "1.081" "0.941" "1.138" "0.780" "1.062" "1.108" "41.4" "35.7" "31.2" "40.8" "44.8" "39.0" "47.2" "32.3" "44.0" "45.9" "" "" "" "" "" "" "" "" "" "" "41.4" "30.2" "19.7" "29.7" "36.7" "30.3" "36.4" "27.8" "34.4" "41.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766745797864106974" "False" "High" "IsMasterProtein" "O75528" "Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1" "0.000" "False" "4.642" "6" "2" "2" "2" "432" "48.9" "6.27" "3.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10198" "10474" "ENSG00000171148" "TADA3" "hsa:10474; O75528; Q6FI83; Q9UFS2" "" "Ub-specific processing proteases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.000" "False" "4.632" "2" "1" "1" "1" "518" "57.4" "5.12" "3.78" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.011" "1.010" "0.906" "1.057" "1.136" "1.106" "1.076" "1.127" "1.177" "89.3" "90.2" "90.2" "80.9" "94.4" "101.4" "98.8" "96.0" "100.6" "105.1" "" "" "" "" "" "" "" "" "" "" "89.3" "76.3" "57.0" "59.0" "77.3" "78.8" "76.1" "82.6" "78.5" "94.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "4.621" "17" "2" "4" "2" "99" "10.7" "9.66" "10.57" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "1.071" "1.011" "0.831" "1.005" "0.838" "0.855" "0.814" "1.004" "1.165" "188.8" "202.2" "190.8" "156.9" "189.7" "158.3" "161.4" "153.7" "189.5" "220.0" "" "" "" "" "" "" "" "" "" "" "188.8" "171.1" "120.6" "114.4" "155.5" "122.9" "124.4" "132.2" "147.9" "197.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.000" "False" "4.621" "2" "1" "1" "1" "485" "54.9" "8.35" "3.31" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "" "Transcriptional activation of mitochondrial biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2379782774127482569" "False" "High" "IsMasterProtein" "Q86YM7" "Homer protein homolog 1 OS=Homo sapiens OX=9606 GN=HOMER1 PE=1 SV=2" "0.000" "False" "4.620" "5" "2" "2" "1" "354" "40.3" "5.44" "5.18" "2" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9456" "ENSG00000152413" "HOMER1" "B2R688; hsa:9456; O96003; Q86YM5; Q86YM7" "BDNF-TrkB signaling; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Orexin receptor pathway; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "7" "0" "1.147" "1.079" "1.201" "1.047" "0.970" "1.024" "1.196" "1.107" "1.054" "49.0" "56.2" "52.9" "58.9" "51.3" "47.5" "50.2" "58.6" "54.2" "51.7" "" "" "" "" "" "" "" "" "" "" "49.0" "47.6" "33.5" "42.9" "42.0" "36.9" "38.7" "50.4" "42.3" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.000" "False" "4.619" "3" "2" "2" "2" "655" "72.3" "7.56" "5.73" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "4.615" "11" "2" "4" "1" "204" "23.0" "4.41" "9.22" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "22q11.2 copy number variation syndrome" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "1" "0.970" "0.936" "1.133" "0.966" "0.810" "1.059" "1.025" "0.921" "0.956" "128.3" "124.5" "120.1" "145.3" "124.0" "103.9" "135.8" "131.6" "118.1" "122.7" "" "" "" "" "" "" "" "" "" "" "128.3" "105.3" "75.9" "106.0" "101.6" "80.7" "104.7" "113.1" "92.2" "110.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479152358026622907" "False" "High" "IsMasterProtein" "Q8WV74" "Mitochondrial coenzyme A diphosphatase NUDT8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2" "0.000" "False" "4.609" "7" "2" "2" "2" "236" "25.4" "8.41" "4.98" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00293" "254552" "ENSG00000167799" "NUDT8" "hsa:254552; Q6ZW59; Q8WV74" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "0.805" "0.760" "0.868" "0.743" "0.678" "0.796" "0.637" "0.801" "0.898" "88.1" "71.0" "67.0" "76.5" "65.5" "59.8" "70.1" "56.2" "70.6" "79.1" "" "" "" "" "" "" "" "" "" "" "88.1" "60.0" "42.4" "55.8" "53.7" "46.4" "54.1" "48.3" "55.1" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "4.604" "6" "1" "1" "1" "280" "31.7" "6.84" "3.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "4.603" "4" "2" "5" "2" "418" "47.3" "5.05" "7.42" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "Histone modifications" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "4.598" "1" "1" "1" "1" "1651" "178.6" "6.86" "3.94" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "0.855" "0.814" "1.088" "1.098" "0.817" "1.100" "0.929" "0.866" "0.919" "56.5" "48.3" "46.0" "61.5" "62.1" "46.2" "62.1" "52.5" "48.9" "51.9" "" "" "" "" "" "" "" "" "" "" "56.5" "40.9" "29.1" "44.8" "50.8" "35.8" "47.9" "45.1" "38.2" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "4.591" "7" "2" "4" "2" "199" "23.6" "9.01" "12.05" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.761" "1.012" "0.783" "0.890" "1.003" "1.031" "0.734" "0.918" "0.895" "103.2" "78.6" "104.5" "80.8" "91.8" "103.5" "106.4" "75.7" "94.8" "92.4" "" "" "" "" "" "" "" "" "" "" "103.2" "66.5" "66.1" "58.9" "75.2" "80.4" "82.0" "65.1" "74.0" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "4.553" "3" "1" "1" "1" "385" "42.4" "8.32" "4.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "1.104" "0.892" "1.062" "1.142" "0.991" "1.261" "1.187" "0.951" "1.103" "91.1" "100.5" "81.2" "96.8" "104.1" "90.3" "114.8" "108.2" "86.6" "100.5" "" "" "" "" "" "" "" "" "" "" "91.1" "85.0" "51.4" "70.6" "85.3" "70.1" "88.5" "93.0" "67.6" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-144841769978260211" "False" "High" "IsMasterProtein" "P16671" "Platelet glycoprotein 4 OS=Homo sapiens OX=9606 GN=CD36 PE=1 SV=2" "0.000" "False" "4.549" "3" "2" "2" "2" "472" "53.0" "7.96" "5.84" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf01130" "948" "ENSG00000135218" "CD36" "D9IX66; D9IX67; D9IX68; D9IX69; hsa:948; P16671; Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; Q9BZN4; Q9BZN5" "Aryl hydrocarbon receptor pathway; PPAR signaling pathway; IL-18 signaling pathway; Genes controlling nephrogenesis; Fatty acid transporters; Cholesterol metabolism; Enterocyte cholesterol metabolism; Vitamin A and carotenoid metabolism" "ER-Phagosome pathway; Transcriptional regulation of white adipocyte differentiation; Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; PPARA activates gene expression; Scavenging by Class B Receptors; Neutrophil degranulation; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Intracellular metabolism of fatty acids regulates insulin secretion; Cross-presentation of particulate exogenous antigens (phagosomes)" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "4.547" "4" "2" "2" "2" "373" "40.4" "8.76" "5.38" "2" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "3" "0" "0.965" "1.084" "1.092" "1.133" "1.080" "0.973" "0.984" "1.162" "1.181" "70.6" "68.1" "76.5" "77.0" "80.0" "76.2" "68.6" "69.4" "82.0" "83.3" "" "" "" "" "" "" "" "" "" "" "70.6" "57.6" "48.4" "56.2" "65.5" "59.2" "52.9" "59.7" "64.0" "74.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "4.545" "8" "1" "1" "1" "186" "21.1" "8.32" "3.85" "1" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "Pyrimidine metabolism" "" "1" "0" "0.961" "1.293" "1.254" "0.608" "1.122" "0.787" "1.049" "0.748" "0.933" "16.4" "15.7" "21.2" "20.5" "10.0" "18.4" "12.9" "17.2" "12.2" "15.3" "" "" "" "" "" "" "" "" "" "" "16.4" "13.3" "13.4" "15.0" "8.2" "14.3" "9.9" "14.8" "9.6" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7191429951444630095" "False" "High" "IsMasterProtein" "Q96RR4" "Calcium/calmodulin-dependent protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=CAMKK2 PE=1 SV=2" "0.000" "False" "4.545" "3" "1" "1" "1" "588" "64.7" "6.68" "3.82" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "10645" "ENSG00000110931" "CAMKK2" "A8K7Q7; hsa:10645; O94883; Q8IUG2; Q8IUG3; Q8N3I4; Q8WY03; Q8WY04; Q8WY05; Q8WY06; Q96RP1; Q96RP2; Q96RR3; Q96RR4; Q9BWE9; Q9UER3; Q9UES2; Q9Y5N2" "AMP-activated protein kinase signaling; VEGFA-VEGFR2 signaling; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis" "Activation of AMPK downstream of NMDARs; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Activation of RAC1 downstream of NMDARs" "10" "0" "1.076" "0.773" "1.087" "0.986" "0.679" "1.151" "0.939" "0.770" "0.779" "34.8" "37.5" "26.9" "37.9" "34.3" "23.7" "40.1" "32.7" "26.8" "27.1" "" "" "" "" "" "" "" "" "" "" "34.8" "31.7" "17.0" "27.6" "28.1" "18.4" "30.9" "28.1" "20.9" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2062699528790100691" "False" "High" "IsMasterProtein" "Q8WYK2" "Jun dimerization protein 2 OS=Homo sapiens OX=9606 GN=JDP2 PE=1 SV=1" "0.000" "False" "4.544" "6" "1" "2" "1" "163" "18.7" "9.23" "7.28" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "122953" "ENSG00000140044" "JDP2" "hsa:122953; J3KN58; O95430; Q8WYK2; Q9UIE4" "" "" "0" "0" "1.044" "0.887" "1.278" "1.157" "1.040" "1.324" "1.128" "0.975" "0.991" "147.7" "154.1" "130.9" "188.7" "170.9" "153.6" "195.6" "166.6" "143.9" "146.4" "" "" "" "" "" "" "" "" "" "" "147.7" "130.4" "82.8" "137.6" "140.0" "119.3" "150.7" "143.2" "112.4" "131.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.000" "False" "4.534" "3" "1" "1" "1" "336" "38.0" "8.54" "3.47" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.928" "0.796" "1.063" "0.942" "1.028" "1.106" "0.882" "0.798" "0.931" "55.4" "51.4" "44.1" "58.9" "52.2" "56.9" "61.3" "48.9" "44.2" "51.5" "" "" "" "" "" "" "" "" "" "" "55.4" "43.5" "27.9" "42.9" "42.7" "44.2" "47.2" "42.0" "34.5" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5267554590826270529" "False" "High" "IsMasterProtein" "P62380" "TATA box-binding protein-like 1 OS=Homo sapiens OX=9606 GN=TBPL1 PE=1 SV=1" "0.000" "False" "4.531" "6" "1" "1" "1" "186" "20.9" "9.54" "3.52" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "9519" "ENSG00000028839" "TBPL1" "A8K8F5; hsa:9519; O95753; P62380; Q9BWD5; Q9Z2Z0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.000" "False" "4.529" "2" "1" "2" "1" "381" "41.9" "5.66" "5.83" "1" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "" "Neutrophil degranulation" "1" "0" "0.902" "0.839" "0.954" "1.063" "0.861" "1.010" "1.101" "0.980" "1.039" "97.4" "87.9" "81.7" "92.9" "103.6" "83.8" "98.4" "107.2" "95.4" "101.2" "" "" "" "" "" "" "" "" "" "" "97.4" "74.3" "51.7" "67.7" "84.9" "65.1" "75.8" "92.2" "74.5" "91.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431357567481647024" "False" "High" "IsMasterProtein" "Q86YD1" "Prostate tumor-overexpressed gene 1 protein OS=Homo sapiens OX=9606 GN=PTOV1 PE=1 SV=1" "0.000" "False" "4.527" "2" "1" "1" "1" "416" "46.8" "10.54" "3.81" "1" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf11232" "53635" "ENSG00000104960" "PTOV1" "hsa:53635; Q6UXX7; Q86YD1; Q96BU3; Q9HBN4; Q9NYL1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8080898461419441815" "False" "High" "IsMasterProtein" "Q66K89" "Transcription factor E4F1 OS=Homo sapiens OX=9606 GN=E4F1 PE=1 SV=2" "0.000" "False" "4.527" "2" "1" "1" "1" "784" "83.4" "6.34" "4.18" "1" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "1877" "ENSG00000167967" "E4F1" "A8K2R4; O00146; Q66K89" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.000" "False" "4.503" "12" "2" "2" "2" "127" "15.0" "4.12" "6.02" "2" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "0.933" "0.869" "0.953" "0.897" "0.899" "1.038" "0.963" "0.878" "0.988" "402.2" "375.4" "349.7" "383.3" "360.8" "361.5" "417.7" "387.4" "353.0" "397.4" "" "" "" "" "" "" "" "" "" "" "402.2" "317.6" "221.1" "279.5" "295.6" "280.7" "322.0" "333.1" "275.6" "357.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.000" "False" "4.501" "7" "1" "1" "1" "137" "15.4" "9.57" "4.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.119" "1.136" "0.988" "1.059" "1.131" "1.117" "1.223" "0.987" "1.046" "114.1" "127.8" "129.7" "112.7" "120.8" "129.0" "127.5" "139.6" "112.7" "119.3" "" "" "" "" "" "" "" "" "" "" "114.1" "108.1" "82.0" "82.2" "99.0" "100.2" "98.3" "120.0" "88.0" "107.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "4.499" "3" "2" "2" "1" "586" "65.6" "6.90" "6.67" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.000" "False" "4.484" "9" "2" "2" "2" "218" "25.0" "6.15" "4.87" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "126204850056993689" "False" "High" "IsMasterProtein" "Q9NPB8" "Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens OX=9606 GN=GPCPD1 PE=1 SV=2" "0.000" "False" "4.479" "2" "1" "1" "1" "672" "76.0" "5.53" "3.30" "1" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00686, Pf03009" "56261" "ENSG00000125772" "GPCPD1" "D3DW06; hsa:56261; Q9BQL8; Q9NPB8; Q9NUX0" "" "Hydrolysis of LPC; Hydrolysis of LPE" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691661012823891973" "False" "High" "IsMasterProtein" "P54278" "Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2" "0.000" "False" "4.472" "2" "1" "1" "1" "862" "95.7" "6.86" "3.38" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01119, Pf08676, Pf13589" "5395" "ENSG00000122512" "PMS2" "B2R610; hsa:5395; P54278; Q52LH6; Q5FBW9; Q5FBX1; Q5FBX2; Q75MR2" "Male infertility; DNA repair pathways, full network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "8" "0" "0.953" "1.251" "1.019" "0.884" "0.891" "1.059" "0.783" "0.795" "1.104" "19.9" "19.0" "24.9" "20.3" "17.6" "17.7" "21.1" "15.6" "15.8" "21.9" "" "" "" "" "" "" "" "" "" "" "19.9" "16.0" "15.7" "14.8" "14.4" "13.8" "16.2" "13.4" "12.3" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "4.448" "4" "2" "2" "2" "409" "46.6" "7.05" "5.83" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "0.959" "1.045" "1.055" "0.997" "0.958" "0.931" "0.935" "1.201" "0.901" "143.3" "137.4" "149.7" "151.1" "142.8" "137.3" "133.4" "133.9" "172.1" "129.2" "" "" "" "" "" "" "" "" "" "" "143.3" "116.2" "94.7" "110.2" "117.0" "106.6" "102.8" "115.2" "134.3" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "High" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.000" "False" "4.446" "1" "1" "1" "1" "805" "92.5" "10.02" "3.39" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "High" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.000" "False" "4.442" "7" "2" "2" "2" "229" "25.0" "9.95" "4.97" "2" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "0.990" "0.731" "1.009" "1.025" "0.879" "1.038" "0.949" "0.787" "0.842" "141.6" "140.2" "103.5" "142.8" "145.1" "124.4" "147.0" "134.4" "111.5" "119.2" "" "" "" "" "" "" "" "" "" "" "141.6" "118.6" "65.4" "104.1" "118.9" "96.6" "113.3" "115.5" "87.0" "107.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257292579144491246" "False" "High" "IsMasterProtein" "Q92544" "Transmembrane 9 superfamily member 4 OS=Homo sapiens OX=9606 GN=TM9SF4 PE=1 SV=2" "0.000" "False" "4.411" "1" "1" "1" "1" "642" "74.5" "6.54" "3.45" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9777" "ENSG00000101337" "TM9SF4" "B0QYT7; hsa:9777; Q92544; Q9NUA3" "" "" "0" "0" "1.135" "1.119" "1.077" "1.084" "1.058" "1.058" "1.197" "0.855" "1.151" "75.4" "85.5" "84.3" "81.2" "81.7" "79.7" "79.7" "90.2" "64.4" "86.8" "" "" "" "" "" "" "" "" "" "" "75.4" "72.3" "53.3" "59.2" "66.9" "61.9" "61.5" "77.6" "50.3" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7554911446023016001" "False" "High" "IsMasterProtein" "P51668" "Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1" "0.000" "False" "4.409" "7" "1" "1" "1" "147" "16.6" "7.42" "4.54" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7321" "ENSG00000072401" "UBE2D1" "A6NLF6; A8K786; hsa:7321; P51668" "Proteasome degradation" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CLEC7A (Dectin-1) signaling; CDK-mediated phosphorylation and removal of Cdc6; Neddylation; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Signaling by BMP; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ovarian tumor domain proteases" "35" "0" "0.892" "0.802" "1.031" "0.882" "0.869" "0.919" "1.001" "0.837" "1.067" "119.9" "106.9" "96.2" "123.7" "105.7" "104.2" "110.2" "120.0" "100.4" "128.0" "" "" "" "" "" "" "" "" "" "" "119.9" "90.5" "60.8" "90.2" "86.6" "80.9" "85.0" "103.2" "78.4" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2405416738570297592" "False" "High" "IsMasterProtein" "Q9NZR1" "Tropomodulin-2 OS=Homo sapiens OX=9606 GN=TMOD2 PE=1 SV=1" "0.000" "False" "4.403" "5" "2" "2" "1" "351" "39.6" "5.27" "5.82" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf03250" "29767" "ENSG00000128872" "TMOD2" "B4DEW6; hsa:29767; Q9NZR1" "" "Striated Muscle Contraction" "1" "0" "1.324" "1.079" "1.357" "1.070" "0.828" "1.289" "1.099" "0.878" "1.020" "26.2" "34.7" "28.3" "35.5" "28.0" "21.7" "33.8" "28.8" "23.0" "26.7" "" "" "" "" "" "" "" "" "" "" "26.2" "29.3" "17.9" "25.9" "23.0" "16.8" "26.0" "24.7" "17.9" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "4.402" "2" "1" "1" "1" "486" "56.2" "6.71" "3.80" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "27" "0" "0.979" "0.874" "1.143" "1.015" "0.991" "0.994" "1.093" "1.028" "1.017" "83.0" "81.3" "72.6" "94.9" "84.2" "82.2" "82.5" "90.7" "85.3" "84.3" "" "" "" "" "" "" "" "" "" "" "83.0" "68.8" "45.9" "69.2" "69.0" "63.8" "63.6" "78.0" "66.6" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "4.402" "18" "2" "14" "2" "44" "5.0" "5.36" "37.08" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "2" "0" "0.968" "1.117" "0.895" "0.852" "0.972" "1.002" "0.932" "0.963" "0.835" "788.9" "763.8" "881.4" "706.3" "672.1" "767.0" "790.6" "735.3" "759.6" "658.8" "" "" "" "" "" "" "" "" "" "" "788.9" "646.2" "557.3" "515.0" "550.6" "595.6" "609.4" "632.2" "592.9" "592.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "4.390" "5" "1" "1" "1" "263" "29.4" "10.02" "3.27" "1" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8368590675514001044" "False" "High" "IsMasterProtein" "Q8N1W2" "Zinc finger protein 710 OS=Homo sapiens OX=9606 GN=ZNF710 PE=1 SV=2" "0.000" "False" "4.389" "3" "1" "1" "1" "664" "74.4" "6.80" "3.70" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "374655" "ENSG00000140548" "ZNF710" "A0AVS3; hsa:374655; Q6ZMK9; Q8N1W2; Q8NDU0" "" "Generic Transcription Pathway" "1" "0" "1.088" "0.836" "0.946" "0.935" "1.003" "1.206" "0.847" "0.674" "1.091" "32.7" "35.6" "27.3" "30.9" "30.6" "32.8" "39.5" "27.7" "22.0" "35.7" "" "" "" "" "" "" "" "" "" "" "32.7" "30.1" "17.3" "22.5" "25.1" "25.5" "30.4" "23.8" "17.2" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925362542189153162" "False" "High" "IsMasterProtein" "Q92854" "Semaphorin-4D OS=Homo sapiens OX=9606 GN=SEMA4D PE=1 SV=1" "0.000" "False" "4.379" "2" "2" "2" "2" "862" "96.1" "7.96" "6.21" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf01403, Pf01437" "10507" "ENSG00000187764" "SEMA4D" "B2RPM6; hsa:10507; Q7Z5S4; Q8N8B0; Q92854" "Clock-controlled autophagy in bone metabolism" "Sema4D induced cell migration and growth-cone collapse; Other semaphorin interactions; Sema4D mediated inhibition of cell attachment and migration" "4" "0" "1.121" "0.926" "1.135" "0.973" "0.858" "1.329" "1.037" "0.910" "1.031" "132.7" "148.8" "122.9" "150.6" "129.1" "113.9" "176.3" "137.6" "120.7" "136.8" "" "" "" "" "" "" "" "" "" "" "132.7" "125.9" "77.7" "109.8" "105.8" "88.4" "135.9" "118.3" "94.2" "123.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-139215625365560454" "False" "High" "IsMasterProtein" "O00566" "U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2" "0.000" "False" "4.377" "1" "1" "1" "1" "681" "78.8" "4.86" "3.40" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf04006" "10199" "ENSG00000124383" "MPHOSPH10" "A0AVJ8; hsa:10199; O00566" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.000" "False" "4.369" "5" "2" "3" "2" "340" "37.7" "6.84" "9.16" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "1.004" "0.948" "1.006" "1.076" "0.977" "1.149" "0.933" "0.849" "0.942" "69.8" "70.1" "66.1" "70.2" "75.1" "68.1" "80.1" "65.1" "59.2" "65.7" "" "" "" "" "" "" "" "" "" "" "69.8" "59.3" "41.8" "51.2" "61.5" "52.9" "61.8" "56.0" "46.2" "59.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6002449157154954042" "False" "High" "IsMasterProtein" "O60346" "PH domain leucine-rich repeat-containing protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PHLPP1 PE=1 SV=3" "0.000" "False" "4.367" "1" "2" "2" "2" "1717" "184.6" "6.28" "5.22" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00169, Pf00481, Pf00560, Pf13516, Pf13855" "23239" "ENSG00000081913" "PHLPP1" "A1A4F5; hsa:23239; O60346; Q641Q7; Q6P4C4; Q6PJI6; Q86TN6; Q96FK2; Q9NUY1" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Negative regulation of the PI3K/AKT network" "3" "0" "1.236" "1.086" "1.073" "0.795" "1.195" "1.166" "1.021" "0.990" "1.239" "17.0" "21.0" "18.4" "18.2" "13.5" "20.3" "19.8" "17.4" "16.8" "21.0" "" "" "" "" "" "" "" "" "" "" "17.0" "17.8" "11.7" "13.3" "11.1" "15.8" "15.3" "14.9" "13.1" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9124413372325642778" "False" "High" "IsMasterProtein" "P12757" "Ski-like protein OS=Homo sapiens OX=9606 GN=SKIL PE=1 SV=2" "0.000" "False" "4.366" "2" "2" "3" "2" "684" "76.9" "7.11" "7.81" "2" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02437, Pf08782" "6498" "ENSG00000136603" "SKIL" "A6NGT1; B4DT50; hsa:6498; O00464; P12756; P12757; Q07501" "Ectoderm differentiation; Lung fibrosis; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; TGF-beta receptor signaling in skeletal dysplasias; Orexin receptor pathway; TGF-beta receptor signaling" "Downregulation of SMAD2/3:SMAD4 transcriptional activity" "8" "0" "1.087" "0.834" "0.989" "1.093" "0.874" "1.034" "1.191" "1.034" "0.995" "114.0" "123.9" "95.0" "112.7" "124.6" "99.7" "117.9" "135.8" "117.9" "113.5" "" "" "" "" "" "" "" "" "" "" "114.0" "104.8" "60.1" "82.2" "102.1" "77.4" "90.9" "116.8" "92.0" "102.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487985857359002276" "False" "High" "IsMasterProtein" "Q8IWU2" "Serine/threonine-protein kinase LMTK2 OS=Homo sapiens OX=9606 GN=LMTK2 PE=1 SV=2" "0.000" "False" "4.365" "1" "1" "1" "1" "1503" "164.8" "4.48" "2.91" "1" "protein metabolism;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf07714" "22853" "ENSG00000164715" "LMTK2" "A4D272; hsa:22853; Q75MG7; Q8IWU2; Q9UPS3" "" "" "0" "0" "0.920" "0.966" "0.888" "1.063" "0.757" "1.054" "0.964" "0.753" "0.839" "24.9" "22.9" "24.1" "22.1" "26.5" "18.9" "26.3" "24.0" "18.8" "20.9" "" "" "" "" "" "" "" "" "" "" "24.9" "19.4" "15.2" "16.1" "21.7" "14.7" "20.2" "20.7" "14.6" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2811612656550812332" "False" "High" "IsMasterProtein" "O75019" "Leukocyte immunoglobulin-like receptor subfamily A member 1 OS=Homo sapiens OX=9606 GN=LILRA1 PE=1 SV=1" "0.000" "False" "4.364" "2" "1" "1" "1" "489" "53.2" "7.84" "3.22" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13895, Pf13927" "11024" "ENSG00000104974; ENSG00000274935; ENSG00000275525; ENSG00000277398" "LILRA1" "hsa:11024; O75018; O75019; Q3MJA6" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "1" "0" "1.029" "0.936" "0.957" "1.017" "0.960" "1.077" "1.007" "1.180" "1.214" "46.6" "47.9" "43.6" "44.6" "47.4" "44.7" "50.2" "46.9" "55.0" "56.5" "" "" "" "" "" "" "" "" "" "" "46.6" "40.5" "27.6" "32.5" "38.8" "34.7" "38.7" "40.3" "42.9" "50.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "4.362" "9" "1" "1" "1" "104" "11.4" "9.25" "3.80" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "High" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.000" "False" "4.361" "4" "2" "2" "2" "452" "51.4" "8.07" "5.62" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "13" "0" "0.940" "0.889" "1.109" "0.968" "0.913" "1.239" "1.082" "0.951" "1.064" "195.1" "183.4" "173.4" "216.3" "188.7" "178.1" "241.6" "211.1" "185.5" "207.5" "" "" "" "" "" "" "" "" "" "" "195.1" "155.1" "109.7" "157.7" "154.6" "138.3" "186.2" "181.5" "144.8" "186.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "4.358" "2" "1" "1" "1" "541" "56.6" "5.48" "3.61" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; Amino acid transport across the plasma membrane" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "4.355" "1" "2" "2" "2" "1792" "201.4" "9.64" "4.74" "2" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "" "RHOBTB1 GTPase cycle; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6663277192588582226" "False" "High" "IsMasterProtein" "Q4G0A6" "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 OS=Homo sapiens OX=9606 GN=MINDY4 PE=1 SV=2" "0.000" "False" "4.351" "2" "1" "1" "1" "757" "84.3" "6.90" "3.43" "1" "protein metabolism" "" "other molecular function" "Pf13898" "84182" "ENSG00000106125" "MINDY4" "Q4G0A6; Q71AZ7; Q9H6D2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "4.344" "5" "1" "2" "1" "179" "20.3" "6.74" "7.59" "1" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "4.343" "6" "2" "2" "2" "325" "37.2" "8.05" "5.06" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Primary focal segmental glomerulosclerosis (FSGS)" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "0.925" "0.896" "1.062" "1.054" "0.911" "1.059" "1.011" "0.982" "0.983" "132.3" "122.3" "118.5" "140.5" "139.4" "120.6" "140.1" "133.7" "130.0" "130.0" "" "" "" "" "" "" "" "" "" "" "132.3" "103.5" "74.9" "102.4" "114.2" "93.6" "108.0" "115.0" "101.4" "116.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5303653638395268189" "False" "High" "IsMasterProtein" "Q16633" "POU domain class 2-associating factor 1 OS=Homo sapiens OX=9606 GN=POU2AF1 PE=1 SV=1" "0.000" "False" "4.333" "4" "1" "1" "1" "256" "27.4" "4.94" "3.44" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09310" "5450" "ENSG00000110777" "POU2AF1" "B2R8Z9; hsa:5450; Q14983; Q16633" "" "" "0" "0" "1.050" "0.839" "1.085" "0.902" "0.857" "0.895" "0.947" "0.968" "1.006" "208.7" "219.1" "175.1" "226.5" "188.2" "178.9" "186.9" "197.6" "202.0" "210.0" "" "" "" "" "" "" "" "" "" "" "208.7" "185.4" "110.7" "165.2" "154.2" "138.9" "144.1" "169.9" "157.7" "188.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479596295726178059" "False" "High" "IsMasterProtein" "P98160" "Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4" "0.000" "False" "4.327" "1" "2" "2" "2" "4391" "468.5" "6.51" "5.14" "2" "other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00008, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf13895, Pf13927" "3339" "ENSG00000142798" "HSPG2" "hsa:3339; P98160; Q16287; Q5SZI3; Q9H3V5" "Hepatitis B infection; Comprehensive IL-17A signaling" "RSV-host interactions; Amyloid fiber formation; Degradation of the extracellular matrix; Integrin cell surface interactions; ECM proteoglycans; Respiratory syncytial virus (RSV) attachment and entry; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Non-integrin membrane-ECM interactions; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Attachment and Entry; Retinoid metabolism and transport; Laminin interactions" "20" "0" "1.676" "1.281" "1.964" "1.800" "1.244" "1.609" "1.790" "1.425" "1.425" "12.3" "20.6" "15.7" "24.1" "22.1" "15.3" "19.8" "22.0" "17.5" "17.5" "" "" "" "" "" "" "" "" "" "" "12.3" "17.4" "10.0" "17.6" "18.1" "11.9" "15.2" "18.9" "13.7" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072940265532369101" "False" "High" "IsMasterProtein" "Q9NY26" "Zinc transporter ZIP1 OS=Homo sapiens OX=9606 GN=SLC39A1 PE=1 SV=1" "0.000" "False" "4.320" "4" "1" "1" "1" "324" "34.2" "5.92" "3.90" "1" "transport;developmental processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;transporter activity" "Pf02535" "27173" "ENSG00000143570" "SLC39A1" "B4DDY7; hsa:27173; Q5T4K1; Q8N2H7; Q9BTV0; Q9NY26; Q9UBI7; Q9Y2Z7; Q9Y380" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis" "Zinc influx into cells by the SLC39 gene family" "4" "0" "1.150" "1.215" "1.284" "1.156" "1.205" "1.386" "1.236" "0.931" "0.969" "38.1" "43.8" "46.3" "49.0" "44.1" "45.9" "52.8" "47.1" "35.5" "37.0" "" "" "" "" "" "" "" "" "" "" "38.1" "37.1" "29.3" "35.7" "36.1" "35.7" "40.7" "40.5" "27.7" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-337966676989864898" "False" "High" "IsMasterProtein" "Q96LB3" "Intraflagellar transport protein 74 homolog OS=Homo sapiens OX=9606 GN=IFT74 PE=1 SV=1" "0.000" "False" "4.316" "3" "2" "2" "2" "600" "69.2" "6.00" "4.16" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "80173" "ENSG00000096872" "IFT74" "hsa:80173; Q3B789; Q5VY34; Q6PGQ8; Q96LB3; Q9H643; Q9H8G7" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7560300285237323007" "False" "High" "IsMasterProtein" "Q12980" "GATOR1 complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1" "0.000" "False" "4.309" "5" "2" "2" "2" "569" "63.6" "6.98" "4.52" "2" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf03666" "8131" "ENSG00000103148" "NPRL3" "D3DU40; hsa:8131; Q12980; Q1W6H0; Q4TT56; Q92469" "22q11.2 copy number variation syndrome" "Amino acids regulate mTORC1" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "4.306" "4" "1" "1" "1" "209" "23.8" "7.39" "3.91" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "" "Glycosphingolipid transport" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "High" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.000" "False" "4.302" "2" "2" "2" "2" "808" "89.0" "6.90" "5.91" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8653500297928283924" "False" "High" "IsMasterProtein" "Q9H7Z3" "Nuclear exosome regulator NRDE2 OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3" "0.000" "False" "4.294" "2" "3" "3" "3" "1164" "132.6" "7.68" "6.32" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08424" "55051" "ENSG00000119720" "NRDE2" "B4DH71; hsa:55051; Q4G0A7; Q9H7Z3; Q9NWH6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2173979595876030532" "False" "High" "IsMasterProtein" "Q9Y4I1" "Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2" "0.000" "False" "4.293" "1" "2" "2" "2" "1855" "215.3" "8.48" "5.01" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4644" "ENSG00000197535" "MYO5A" "A8MZC5; hsa:4644; O60653; Q07902; Q16249; Q9UE30; Q9UE31; Q9Y4I1" "Joubert syndrome; 2q37 copy number variation syndrome" "Regulation of actin dynamics for phagocytic cup formation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; FCGR3A-mediated phagocytosis" "6" "0" "1.034" "0.991" "1.012" "0.947" "0.919" "1.198" "1.046" "1.000" "1.026" "52.4" "54.2" "51.9" "53.0" "49.6" "48.2" "62.8" "54.8" "52.4" "53.8" "" "" "" "" "" "" "" "" "" "" "52.4" "45.9" "32.8" "38.7" "40.7" "37.4" "48.4" "47.2" "40.9" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5930476095621651501" "False" "High" "IsMasterProtein" "Q15283" "Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3" "0.000" "False" "4.284" "2" "2" "2" "2" "850" "96.6" "7.20" "5.32" "2" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "5922" "ENSG00000155903" "RASA2" "A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2" "MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation" "Regulation of RAS by GAPs" "5" "0" "0.719" "0.920" "0.949" "1.060" "0.787" "1.059" "1.014" "0.708" "0.825" "42.2" "30.3" "38.8" "40.0" "44.7" "33.2" "44.7" "42.8" "29.9" "34.8" "" "" "" "" "" "" "" "" "" "" "42.2" "25.7" "24.6" "29.2" "36.7" "25.8" "34.4" "36.8" "23.3" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-32150545336103988" "False" "High" "IsMasterProtein" "Q14687" "Genetic suppressor element 1 OS=Homo sapiens OX=9606 GN=GSE1 PE=1 SV=3" "0.000" "False" "4.278" "2" "2" "2" "2" "1217" "136.1" "7.74" "2.93" "2" "" "" "" "Pf12540" "23199" "ENSG00000131149" "GSE1" "D3DUM4; hsa:23199; Q14687; Q8IY61; Q96GA4; Q9BW09" "" "" "0" "0" "1.895" "1.310" "1.799" "1.862" "1.390" "1.443" "1.390" "1.591" "1.622" "13.9" "26.3" "18.2" "24.9" "25.8" "19.3" "20.0" "19.3" "22.1" "22.5" "" "" "" "" "" "" "" "" "" "" "13.9" "22.2" "11.5" "18.2" "21.1" "15.0" "15.4" "16.6" "17.2" "20.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.000" "False" "4.272" "6" "2" "2" "2" "248" "27.6" "5.30" "5.93" "2" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1906728962657119093" "False" "High" "IsMasterProtein" "Q13077" "TNF receptor-associated factor 1 OS=Homo sapiens OX=9606 GN=TRAF1 PE=1 SV=1" "0.000" "False" "4.266" "4" "2" "2" "2" "416" "46.1" "6.11" "5.73" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16673, Pf21355" "7185" "ENSG00000056558" "TRAF1" "B4DJ77; hsa:7185; Q13077; Q658U1; Q8NF13" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Oxidative damage response; Small cell lung cancer; IL-18 signaling pathway; 16p11.2 distal deletion syndrome; Genes associated with the development of rheumatoid arthritis; 13q12.12 copy number variation" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway" "14" "0" "1.166" "0.906" "1.146" "1.165" "0.996" "1.217" "1.250" "1.039" "0.992" "48.6" "56.7" "44.0" "55.7" "56.6" "48.4" "59.1" "60.7" "50.5" "48.2" "" "" "" "" "" "" "" "" "" "" "48.6" "47.9" "27.8" "40.6" "46.4" "37.6" "45.6" "52.2" "39.4" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1623430571812818172" "False" "High" "IsMasterProtein" "Q9Y4G8" "Rap guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=RAPGEF2 PE=1 SV=1" "0.000" "False" "4.258" "1" "1" "1" "1" "1499" "167.3" "6.67" "3.35" "1" "cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00595, Pf00617, Pf00618, Pf00788" "9693" "ENSG00000109756" "RAPGEF2" "D3DP27; hsa:9693; Q9Y4G8" "MAPK signaling pathway" "RAF/MAP kinase cascade" "2" "0" "1.006" "1.049" "1.182" "1.108" "1.028" "1.202" "1.085" "0.993" "1.163" "69.5" "69.9" "72.9" "82.1" "77.0" "71.4" "83.5" "75.4" "69.0" "80.8" "" "" "" "" "" "" "" "" "" "" "69.5" "59.1" "46.1" "59.9" "63.1" "55.4" "64.4" "64.8" "53.8" "72.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "4.257" "5" "1" "1" "1" "217" "23.3" "4.98" "3.86" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.221" "0.878" "1.081" "1.119" "1.008" "1.187" "1.087" "0.909" "1.022" "73.0" "89.1" "64.0" "78.9" "81.7" "73.6" "86.6" "79.3" "66.3" "74.6" "" "" "" "" "" "" "" "" "" "" "73.0" "75.4" "40.5" "57.5" "66.9" "57.1" "66.7" "68.2" "51.8" "67.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3477378732405532846" "False" "High" "IsMasterProtein" "Q5TCX8" "Mitogen-activated protein kinase kinase kinase 21 OS=Homo sapiens OX=9606 GN=MAP3K21 PE=1 SV=3" "0.000" "False" "4.254" "2" "2" "2" "2" "1036" "113.9" "8.73" "5.44" "2" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf07714, Pf14604" "84451" "ENSG00000143674" "MAP3K21" "A0A1W2PKR9; B2RN34; hsa:84451; Q5TCX7; Q5TCX8; Q5TCX9; Q8WWN1; Q8WWN2; Q96JM1; X6R610" "" "" "0" "0" "0.988" "0.910" "1.054" "1.176" "1.050" "1.050" "1.139" "0.912" "0.996" "57.6" "56.9" "52.4" "60.7" "67.7" "60.4" "60.4" "65.6" "52.5" "57.3" "" "" "" "" "" "" "" "" "" "" "57.6" "48.1" "33.1" "44.3" "55.5" "46.9" "46.6" "56.4" "41.0" "51.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5997632050867013674" "False" "High" "IsMasterProtein" "Q9UGR2" "Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2" "0.000" "False" "4.248" "1" "1" "1" "1" "977" "109.8" "7.25" "3.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf13181" "23264" "ENSG00000100403" "ZC3H7B" "A7YY88; B2RCA4; hsa:23264; Q5TFX9; Q8TBT9; Q9H8B6; Q9UGQ9; Q9UGR0; Q9UGR1; Q9UGR2; Q9UK03; Q9UPW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7520728591750181120" "False" "High" "IsMasterProtein" "O00625" "Pirin OS=Homo sapiens OX=9606 GN=PIR PE=1 SV=1" "0.000" "False" "4.246" "6" "2" "2" "2" "290" "32.1" "6.92" "5.23" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02678, Pf05726" "8544" "ENSG00000087842" "PIR" "hsa:8544; O00625; Q5U0G0; Q6FHD2" "" "Digestion" "1" "0" "1.044" "1.530" "1.067" "1.226" "1.151" "1.319" "1.028" "1.231" "0.899" "18.8" "19.7" "28.8" "20.1" "23.1" "21.7" "24.8" "19.4" "23.2" "16.9" "" "" "" "" "" "" "" "" "" "" "18.8" "16.6" "18.2" "14.7" "18.9" "16.8" "19.1" "16.7" "18.1" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949732143901396407" "False" "High" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "0.000" "False" "4.244" "3" "1" "1" "1" "364" "41.9" "6.48" "3.94" "1" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "Modulators of TCR signaling and T cell activation" "" "1" "0" "0.975" "1.069" "1.049" "1.053" "0.878" "1.089" "1.201" "0.935" "0.984" "53.7" "52.4" "57.4" "56.3" "56.5" "47.2" "58.5" "64.5" "50.2" "52.9" "" "" "" "" "" "" "" "" "" "" "53.7" "44.3" "36.3" "41.1" "46.3" "36.6" "45.1" "55.4" "39.2" "47.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2010666374773995606" "False" "High" "IsMasterProtein" "Q06587" "E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2" "0.000" "False" "4.243" "6" "2" "2" "1" "406" "42.4" "5.62" "5.32" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00097, Pf16207" "6015" "ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107" "RING1" "A8JZZ0; Q06587; Q5JP96; Q5SQW2; Q86V19" "Pleural mesothelioma; Notch signaling pathway" "Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "11" "0" "1.066" "1.228" "1.168" "1.078" "1.015" "1.030" "1.095" "1.141" "0.958" "41.7" "44.5" "51.2" "48.7" "44.9" "42.3" "43.0" "45.6" "47.6" "39.9" "" "" "" "" "" "" "" "" "" "" "41.7" "37.6" "32.4" "35.5" "36.8" "32.9" "33.1" "39.2" "37.1" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7254766562605531244" "False" "High" "IsMasterProtein" "P62324" "Protein BTG1 OS=Homo sapiens OX=9606 GN=BTG1 PE=1 SV=1" "0.000" "False" "4.239" "6" "1" "1" "1" "171" "19.2" "8.18" "3.44" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07742" "694" "ENSG00000133639" "BTG1" "hsa:694; P31607; P62324" "Exercise-induced circadian regulation" "FOXO-mediated transcription of cell cycle genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803937283949644789" "False" "High" "IsMasterProtein" "O15381" "Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1" "0.000" "False" "4.226" "2" "2" "2" "2" "856" "95.0" "6.48" "4.63" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00004, Pf16725, Pf17862" "4931" "ENSG00000143748" "NVL" "B4DMC4; B4DP98; hsa:4931; O15381; Q96EM7" "" "" "0" "0" "1.133" "1.319" "1.027" "1.209" "1.778" "1.149" "1.142" "1.666" "1.410" "116.5" "132.0" "153.6" "119.6" "140.9" "207.2" "133.9" "133.1" "194.1" "164.2" "" "" "" "" "" "" "" "" "" "" "116.5" "111.7" "97.1" "87.2" "115.4" "160.9" "103.2" "114.4" "151.5" "147.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "High" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.000" "False" "4.225" "7" "1" "1" "1" "125" "14.6" "9.07" "3.57" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "Mitochondrial complex II assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "4.224" "4" "1" "1" "1" "262" "29.6" "6.96" "2.95" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147390557476055838" "False" "High" "IsMasterProtein" "Q9BYT3" "Serine/threonine-protein kinase 33 OS=Homo sapiens OX=9606 GN=STK33 PE=1 SV=1" "0.000" "False" "4.223" "5" "3" "3" "3" "514" "57.8" "7.03" "4.13" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "65975" "ENSG00000130413" "STK33" "hsa:65975; Q658S6; Q8NEF5; Q9BYT3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "4.215" "6" "2" "2" "2" "280" "31.6" "8.76" "5.64" "2" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "7" "0" "1.210" "1.098" "1.086" "1.091" "1.089" "1.026" "0.988" "1.081" "0.963" "84.0" "101.7" "92.2" "91.3" "91.7" "91.5" "86.2" "83.0" "90.8" "80.9" "" "" "" "" "" "" "" "" "" "" "84.0" "86.0" "58.3" "66.6" "75.1" "71.1" "66.4" "71.4" "70.9" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3764290193644051117" "False" "High" "IsMasterProtein" "Q8WU10" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1" "0.000" "False" "4.214" "2" "1" "1" "1" "500" "55.8" "5.85" "2.15" "1" "stress response" "cytoskeleton;nucleus" "other molecular function" "Pf07992, Pf18267" "79912" "ENSG00000121350" "PYROXD1" "A6NKI6; B3KWN8; hsa:79912; Q8WU10; Q9H6P1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "4.214" "2" "2" "2" "2" "726" "80.6" "8.78" "5.46" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "17" "0" "1.013" "0.956" "1.088" "1.205" "1.039" "1.053" "1.143" "0.994" "0.969" "69.8" "70.7" "66.7" "75.9" "84.1" "72.5" "73.5" "79.8" "69.4" "67.7" "" "" "" "" "" "" "" "" "" "" "69.8" "59.8" "42.2" "55.4" "68.9" "56.3" "56.6" "68.6" "54.2" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-62154573745771927" "False" "High" "IsMasterProtein" "Q9NRG9" "Aladin OS=Homo sapiens OX=9606 GN=AAAS PE=1 SV=1" "0.000" "False" "4.210" "2" "1" "1" "1" "546" "59.5" "7.50" "3.52" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "" "Pf00400" "8086" "ENSG00000094914; ENSG00000291836" "AAAS" "hsa:8086; Q5JB47; Q9NRG9; Q9NWI6; Q9UG19" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RHOA GTPase cycle; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "29" "0" "0.983" "0.725" "0.969" "1.016" "0.886" "0.989" "0.982" "0.880" "0.894" "87.6" "86.2" "63.5" "84.9" "89.1" "77.6" "86.7" "86.0" "77.1" "78.3" "" "" "" "" "" "" "" "" "" "" "87.6" "72.9" "40.1" "61.9" "73.0" "60.3" "66.8" "74.0" "60.2" "70.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818998789770137613" "False" "High" "IsMasterProtein" "Q9Y4W6" "Mitochondrial inner membrane m-AAA protease component AFG3L2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2" "0.000" "False" "4.209" "1" "1" "1" "1" "797" "88.5" "8.66" "4.10" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "10939" "ENSG00000141385" "AFG3L2" "hsa:10939; Q6P1L0; Q9Y4W6" "Ciliary landscape; 10q22q23 copy number variation" "Mitochondrial protein degradation; Processing of SMDT1" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "825951420826884356" "False" "High" "IsMasterProtein" "Q9NWB7" "Intraflagellar transport protein 57 homolog OS=Homo sapiens OX=9606 GN=IFT57 PE=1 SV=1" "0.000" "False" "4.196" "3" "1" "1" "1" "429" "49.1" "4.98" "3.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf10498" "55081" "ENSG00000114446" "IFT57" "hsa:55081; Q96DA9; Q9NWB7" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "Intraflagellar transport; Hedgehog 'off' state" "6" "0" "1.030" "0.906" "1.091" "1.181" "0.863" "1.066" "0.916" "0.900" "0.940" "55.2" "56.8" "50.0" "60.2" "65.2" "47.6" "58.9" "50.6" "49.7" "51.9" "" "" "" "" "" "" "" "" "" "" "55.2" "48.1" "31.6" "43.9" "53.4" "37.0" "45.4" "43.5" "38.8" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "4.196" "1" "1" "1" "1" "789" "90.8" "5.43" "3.03" "1" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "2" "0" "1.275" "1.100" "1.138" "1.080" "1.099" "1.115" "1.050" "1.016" "0.863" "75.5" "96.3" "83.0" "86.0" "81.5" "83.0" "84.2" "79.2" "76.7" "65.1" "" "" "" "" "" "" "" "" "" "" "75.5" "81.4" "52.5" "62.7" "66.8" "64.4" "64.9" "68.1" "59.9" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "4.194" "1" "1" "1" "1" "701" "80.6" "7.56" "3.76" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "4.187" "6" "2" "2" "2" "417" "46.3" "7.37" "4.80" "2" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.000" "False" "4.184" "1" "1" "2" "1" "614" "64.8" "8.73" "5.92" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "1.032" "0.968" "1.026" "1.050" "1.142" "1.073" "1.077" "1.171" "1.017" "242.4" "250.2" "234.6" "248.8" "254.5" "276.8" "260.1" "261.0" "283.9" "246.4" "" "" "" "" "" "" "" "" "" "" "242.4" "211.7" "148.3" "181.4" "208.5" "214.9" "200.5" "224.4" "221.6" "221.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6924656061698190740" "False" "High" "IsMasterProtein" "Cont_Q2UVX4" "Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2" "0.000" "True" "4.182" "1" "1" "1" "1" "1661" "187.1" "6.84" "3.54" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17790, Pf17791, Pf21308, Pf21406" "280677" "ENSBTAG00000017280" "C3" "bta:280677; Q2KIZ4; Q2UVX4" "Complement and coagulation cascades; Complement activation, classical pathway" "Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "11" "0" "0.705" "0.748" "0.837" "0.664" "0.913" "0.584" "0.641" "1.054" "0.879" "84.2" "59.4" "63.0" "70.5" "55.9" "76.9" "49.2" "54.0" "88.7" "74.0" "" "" "" "" "" "" "" "" "" "" "84.2" "50.3" "39.8" "51.4" "45.8" "59.7" "37.9" "46.4" "69.3" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "4.180" "9" "1" "1" "1" "116" "13.2" "5.00" "3.91" "1" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "1.017" "0.996" "1.187" "1.204" "1.074" "1.196" "1.009" "0.998" "1.090" "112.5" "114.4" "112.1" "133.6" "135.5" "120.9" "134.5" "113.6" "112.3" "122.7" "" "" "" "" "" "" "" "" "" "" "112.5" "96.8" "70.9" "97.4" "111.0" "93.9" "103.7" "97.6" "87.7" "110.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2540636687362609874" "False" "High" "IsMasterProtein" "O94768" "Serine/threonine-protein kinase 17B OS=Homo sapiens OX=9606 GN=STK17B PE=1 SV=1" "0.000" "False" "4.177" "2" "1" "1" "1" "372" "42.3" "5.25" "3.95" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9262" "ENSG00000081320" "STK17B" "hsa:9262; O94768" "" "" "0" "0" "1.077" "0.874" "0.847" "0.933" "0.804" "0.949" "1.184" "0.806" "0.914" "135.6" "146.1" "118.6" "114.9" "126.6" "109.0" "128.8" "160.6" "109.3" "124.0" "" "" "" "" "" "" "" "" "" "" "135.6" "123.6" "75.0" "83.7" "103.7" "84.7" "99.3" "138.1" "85.3" "111.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1862365170183324257" "False" "High" "IsMasterProtein" "P56182" "Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1" "0.000" "False" "4.176" "3" "1" "1" "1" "461" "52.8" "9.33" "2.63" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05997" "8568" "ENSG00000160214" "RRP1" "hsa:8568; P56182; Q9NST5" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "4.171" "2" "2" "2" "1" "734" "84.6" "8.59" "5.02" "2" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1137572445612648044" "False" "High" "IsMasterProtein" "Q7Z4L5" "Tetratricopeptide repeat protein 21B OS=Homo sapiens OX=9606 GN=TTC21B PE=1 SV=2" "0.000" "False" "4.167" "2" "2" "2" "2" "1316" "150.8" "6.96" "4.13" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13176, Pf13181, Pf14559" "79809" "ENSG00000123607" "TTC21B" "A8MUZ3; Q3LIE4; Q53T84; Q6P4A1; Q6PIF5; Q7Z4L5; Q8NCN3; Q96MA4; Q9HAK8" "Nephrotic syndrome; Ciliopathies; Bardet-Biedl syndrome" "Intraflagellar transport; Hedgehog 'off' state" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "4.164" "2" "2" "2" "2" "977" "107.1" "10.08" "4.71" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "1.350" "1.209" "1.082" "1.080" "1.177" "1.078" "1.380" "1.105" "1.327" "19.4" "26.2" "23.5" "21.0" "21.0" "22.8" "20.9" "26.8" "21.4" "25.8" "" "" "" "" "" "" "" "" "" "" "19.4" "22.2" "14.8" "15.3" "17.2" "17.7" "16.1" "23.0" "16.7" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8643593738164187642" "False" "High" "IsMasterProtein" "Q9H6S0" "3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2" "0.000" "False" "4.161" "1" "2" "2" "2" "1430" "160.1" "8.40" "4.58" "2" "cell cycle OR cell proliferation;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf00270, Pf00271, Pf01424, Pf04146, Pf04408, Pf07717, Pf21010" "64848" "ENSG00000047188" "YTHDC2" "B2RP66; hsa:64848; Q9H6S0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.000" "False" "4.153" "2" "1" "1" "1" "755" "81.4" "7.74" "3.04" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "" "Regulation of innate immune responses to cytosolic DNA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4523717261131920154" "False" "High" "IsMasterProtein" "Q8NEZ4" "Histone-lysine N-methyltransferase 2C OS=Homo sapiens OX=9606 GN=KMT2C PE=1 SV=3" "0.000" "False" "4.152" "0" "1" "1" "1" "4911" "541.0" "6.49" "3.82" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "58508" "ENSG00000055609" "KMT2C" "hsa:58508; Q8NC02; Q8NDF6; Q8NEZ4; Q9H9P4; Q9NR13; Q9P222; Q9UDR7" "Histone modifications; Pathways affected in adenoid cystic carcinoma; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Formation of WDR5-containing histone-modifying complexes" "9" "0" "1.321" "0.794" "1.509" "1.108" "1.006" "1.258" "1.107" "1.245" "1.149" "24.0" "31.7" "19.0" "36.2" "26.5" "24.1" "30.1" "26.5" "29.8" "27.5" "" "" "" "" "" "" "" "" "" "" "24.0" "26.8" "12.0" "26.4" "21.7" "18.7" "23.2" "22.8" "23.3" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-984434890743612814" "False" "High" "IsMasterProtein" "Q96A57" "Transmembrane protein 230 OS=Homo sapiens OX=9606 GN=TMEM230 PE=1 SV=1" "0.000" "False" "4.151" "10" "1" "1" "1" "120" "13.2" "9.31" "2.28" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf05915" "29058" "ENSG00000089063" "TMEM230" "B2RDM8; D3DVZ9; hsa:29058; Q0VGC8; Q5TDS5; Q96A57; Q96ES2; Q9P0A7" "" "" "0" "0" "0.872" "0.777" "1.151" "0.952" "1.011" "1.307" "1.053" "0.967" "0.935" "39.1" "34.1" "30.4" "45.0" "37.2" "39.5" "51.1" "41.2" "37.8" "36.5" "" "" "" "" "" "" "" "" "" "" "39.1" "28.8" "19.2" "32.8" "30.5" "30.7" "39.4" "35.4" "29.5" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4192165975954364853" "False" "High" "IsMasterProtein" "Q93015" "N-alpha-acetyltransferase 80 OS=Homo sapiens OX=9606 GN=NAA80 PE=1 SV=2" "0.000" "False" "4.148" "4" "1" "1" "1" "286" "31.4" "7.85" "3.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00583" "24142" "ENSG00000243477" "NAA80" "hsa:24142; Q93014; Q93015" "Metapathway biotransformation Phase I and II" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "High" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.000" "False" "4.146" "4" "2" "2" "1" "482" "52.7" "6.10" "4.67" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "15q25 copy number variation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3850938661228975130" "False" "High" "IsMasterProtein" "Q9NQ55" "Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=1 SV=1" "0.000" "False" "4.139" "3" "1" "1" "1" "473" "53.2" "10.13" "3.14" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "56342; 692312" "ENSG00000130810" "PPAN" "C9J3F9; hsa:56342; hsa:692312; Q9BW97; Q9H170; Q9NQ55" "" "" "0" "0" "0.728" "0.799" "0.722" "1.070" "1.074" "0.898" "0.843" "0.965" "0.754" "35.8" "26.0" "28.6" "25.8" "38.2" "38.4" "32.1" "30.1" "34.5" "27.0" "" "" "" "" "" "" "" "" "" "" "35.8" "22.0" "18.1" "18.8" "31.3" "29.8" "24.7" "25.9" "26.9" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3050786431982256186" "False" "High" "IsMasterProtein" "Q53ET0" "CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2" "0.000" "False" "4.135" "4" "2" "2" "2" "693" "73.3" "7.11" "2.79" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "200186" "ENSG00000160741" "CRTC2" "hsa:200186; Q53ET0; Q6UUV8; Q7Z3X7; Q8N332" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Circadian Clock; Heme signaling; Transcriptional activation of mitochondrial biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.000" "False" "4.132" "3" "1" "1" "1" "285" "32.7" "5.12" "3.52" "1" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "1.137" "1.028" "1.134" "1.276" "1.072" "1.209" "1.013" "0.827" "1.123" "65.5" "74.5" "67.3" "74.3" "83.6" "70.2" "79.1" "66.3" "54.1" "73.5" "" "" "" "" "" "" "" "" "" "" "65.5" "63.0" "42.6" "54.2" "68.5" "54.5" "61.0" "57.0" "42.3" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7124655669919314751" "False" "High" "IsMasterProtein" "Q5T7V8" "RAB6-interacting golgin OS=Homo sapiens OX=9606 GN=GORAB PE=1 SV=2" "0.000" "False" "4.127" "3" "1" "2" "1" "369" "42.2" "6.48" "5.50" "1" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf04949" "92344" "ENSG00000120370" "GORAB" "hsa:92344; Q49A22; Q5T7V8; Q6P1P9; Q9HAE6; Q9Y350" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "High" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.000" "False" "4.116" "2" "1" "1" "1" "381" "41.0" "5.01" "3.58" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "High" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.000" "False" "4.112" "12" "2" "2" "2" "149" "17.0" "6.00" "5.04" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "1.127" "0.882" "1.012" "1.043" "1.008" "1.228" "0.930" "1.183" "0.998" "31.0" "35.0" "27.4" "31.4" "32.4" "31.3" "38.1" "28.8" "36.7" "31.0" "" "" "" "" "" "" "" "" "" "" "31.0" "29.6" "17.3" "22.9" "26.5" "24.3" "29.4" "24.8" "28.7" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "4.111" "3" "2" "2" "1" "632" "71.1" "7.42" "5.27" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4471823552801457794" "False" "High" "IsMasterProtein" "Q9GZN1" "Actin-related protein 6 OS=Homo sapiens OX=9606 GN=ACTR6 PE=1 SV=1" "0.000" "False" "4.111" "4" "2" "2" "2" "396" "45.8" "5.03" "5.72" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "64431" "ENSG00000075089" "ACTR6" "B3KW37; B4DLG9; hsa:64431; Q53GH2; Q9BY39; Q9GZN1; Q9H8H6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "4.102" "2" "1" "1" "1" "477" "54.2" "6.15" "3.41" "1" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "1.132" "2.669" "1.223" "1.197" "2.819" "1.496" "1.171" "2.877" "1.731" "102.5" "116.1" "273.7" "125.4" "122.7" "289.0" "153.4" "120.0" "295.0" "177.5" "" "" "" "" "" "" "" "" "" "" "102.5" "98.2" "173.0" "91.5" "100.6" "224.5" "118.3" "103.2" "230.2" "159.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4605522544337800066" "False" "High" "IsMasterProtein" "Q9Y3U8" "Large ribosomal subunit protein eL36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3" "0.000" "False" "4.099" "10" "1" "1" "1" "105" "12.2" "11.59" "4.02" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01158" "25873" "ENSG00000130255" "RPL36" "B2R4Y1; D6W634; hsa:25873; Q6FIG1; Q9UQF6; Q9Y3U8" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.050" "1.798" "1.015" "1.273" "1.992" "1.211" "1.464" "1.969" "1.383" "78.7" "82.7" "141.5" "79.9" "100.2" "156.8" "95.3" "115.3" "155.1" "108.9" "" "" "" "" "" "" "" "" "" "" "78.7" "69.9" "89.5" "58.3" "82.1" "121.8" "73.5" "99.1" "121.0" "97.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "High" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.000" "False" "4.098" "1" "1" "1" "1" "785" "88.2" "5.45" "3.76" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "4" "0" "1.053" "0.712" "1.219" "1.221" "0.974" "1.163" "0.992" "0.837" "0.931" "50.8" "53.5" "36.2" "61.9" "62.0" "49.5" "59.1" "50.4" "42.5" "47.3" "" "" "" "" "" "" "" "" "" "" "50.8" "45.3" "22.9" "45.2" "50.8" "38.5" "45.6" "43.4" "33.2" "42.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.000" "False" "4.094" "4" "1" "2" "1" "294" "32.9" "9.09" "5.15" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076794450194740666" "False" "High" "IsMasterProtein" "Q5JWR5" "Protein dopey-1 OS=Homo sapiens OX=9606 GN=DOP1A PE=1 SV=1" "0.000" "False" "4.091" "1" "2" "2" "2" "2465" "277.2" "6.29" "4.70" "2" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf04118" "23033" "ENSG00000083097" "DOP1A" "hsa:23033; Q5JWR5; Q86XV1; Q9H5J5; Q9NSL4; Q9UPN5; Q9Y414" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "4.088" "2" "2" "2" "2" "1048" "115.2" "8.48" "5.30" "2" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "" "Estrogen-dependent gene expression" "1" "0" "0.959" "0.827" "1.152" "1.075" "1.011" "1.032" "1.157" "0.894" "1.060" "75.0" "71.9" "62.0" "86.4" "80.6" "75.8" "77.4" "86.7" "67.0" "79.5" "" "" "" "" "" "" "" "" "" "" "75.0" "60.8" "39.2" "63.0" "66.0" "58.9" "59.7" "74.6" "52.3" "71.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.000" "False" "4.087" "2" "1" "1" "1" "455" "50.6" "9.10" "2.55" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.000" "False" "4.076" "3" "2" "2" "2" "597" "66.7" "6.35" "4.63" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.000" "False" "4.072" "8" "1" "1" "1" "130" "14.5" "9.85" "3.10" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.205" "0.868" "1.279" "1.115" "1.164" "1.111" "1.133" "1.049" "1.057" "52.0" "62.7" "45.2" "66.5" "58.0" "60.6" "57.8" "58.9" "54.6" "55.0" "" "" "" "" "" "" "" "" "" "" "52.0" "53.0" "28.6" "48.5" "47.5" "47.0" "44.5" "50.7" "42.6" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7841713393868884800" "False" "High" "IsMasterProtein" "Q9BSL1" "Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1" "0.000" "False" "4.069" "5" "2" "3" "2" "405" "45.3" "4.92" "6.06" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00627" "10422" "ENSG00000130560" "UBAC1" "hsa:10422; O75500; Q9BSL1; Q9UMW7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.006" "1.086" "1.240" "1.176" "1.147" "1.228" "1.257" "1.014" "1.152" "75.7" "76.1" "82.2" "93.9" "89.0" "86.8" "92.9" "95.1" "76.7" "87.2" "" "" "" "" "" "" "" "" "" "" "75.7" "64.4" "52.0" "68.4" "72.9" "67.4" "71.6" "81.8" "59.9" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717831225161761415" "False" "High" "IsMasterProtein" "P46100" "Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=6" "0.000" "False" "4.063" "0" "1" "1" "1" "2492" "282.4" "6.55" "2.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf17981" "546" "ENSG00000085224" "ATRX" "D3DTE2; P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3" "Pathways affected in adenoid cystic carcinoma" "Inhibition of DNA recombination at telomere; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097658218394758056" "False" "High" "IsMasterProtein" "P54259" "Atrophin-1 OS=Homo sapiens OX=9606 GN=ATN1 PE=1 SV=3" "0.000" "False" "4.061" "1" "1" "1" "1" "1190" "125.3" "8.98" "3.19" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03154" "1822" "ENSG00000111676" "ATN1" "hsa:1822; P54259; Q99495; Q99621; Q9UEK7" "" "Regulation of PTEN gene transcription" "1" "0" "1.047" "0.799" "1.195" "1.149" "0.911" "1.002" "1.249" "0.947" "1.050" "101.4" "106.3" "81.1" "121.2" "116.6" "92.4" "101.6" "126.7" "96.1" "106.5" "" "" "" "" "" "" "" "" "" "" "101.4" "89.9" "51.3" "88.4" "95.5" "71.8" "78.3" "108.9" "75.0" "95.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.000" "False" "4.054" "8" "1" "3" "1" "247" "26.5" "6.51" "5.03" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "2" "0" "1.169" "1.384" "1.474" "1.255" "1.854" "1.378" "1.205" "1.537" "1.076" "175.3" "205.0" "242.7" "258.4" "220.0" "325.1" "241.6" "211.3" "269.4" "188.7" "" "" "" "" "" "" "" "" "" "" "175.3" "173.4" "153.5" "188.4" "180.2" "252.5" "186.2" "181.7" "210.3" "169.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1503815789163397173" "False" "High" "IsMasterProtein" "Q9NRG7" "Epimerase family protein SDR39U1 OS=Homo sapiens OX=9606 GN=SDR39U1 PE=1 SV=3" "0.000" "False" "4.050" "3" "1" "1" "1" "293" "31.1" "9.04" "3.61" "1" "" "" "other molecular function" "Pf01370, Pf08338" "56948" "ENSG00000100445" "SDR39U1" "hsa:56948; Q6ZW71; Q9BVQ3; Q9NRG7" "" "" "0" "0" "0.926" "0.862" "1.034" "1.012" "0.957" "1.116" "0.992" "0.932" "1.049" "120.8" "111.8" "104.1" "124.9" "122.2" "115.6" "134.8" "119.8" "112.6" "126.6" "" "" "" "" "" "" "" "" "" "" "120.8" "94.6" "65.8" "91.0" "100.1" "89.8" "103.9" "103.0" "87.9" "113.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-567080843799231126" "False" "High" "IsMasterProtein" "Q9NVF7" "F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1" "0.000" "False" "4.044" "4" "2" "2" "2" "368" "41.1" "9.55" "5.22" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00646" "23219" "ENSG00000143756" "FBXO28" "E9PEM8; hsa:23219; O75070; Q9NVF7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.000" "False" "4.040" "3" "2" "4" "2" "615" "70.7" "9.36" "8.28" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "18" "0" "1.100" "1.215" "1.090" "1.219" "1.277" "1.197" "1.110" "1.302" "1.235" "185.5" "204.1" "225.4" "202.1" "226.1" "236.8" "222.0" "205.9" "241.5" "229.1" "" "" "" "" "" "" "" "" "" "" "185.5" "172.7" "142.5" "147.4" "185.3" "183.9" "171.1" "177.0" "188.5" "206.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "4.031" "1" "1" "1" "1" "658" "73.8" "6.33" "3.77" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.191" "1.023" "0.982" "1.248" "1.177" "1.177" "1.133" "0.929" "1.038" "74.7" "89.0" "76.4" "73.4" "93.2" "87.9" "87.9" "84.6" "69.3" "77.5" "" "" "" "" "" "" "" "" "" "" "74.7" "75.3" "48.3" "53.5" "76.4" "68.3" "67.7" "72.7" "54.1" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8326576177653758886" "False" "High" "IsMasterProtein" "O60447" "Ecotropic viral integration site 5 protein homolog OS=Homo sapiens OX=9606 GN=EVI5 PE=1 SV=3" "0.000" "False" "4.028" "1" "1" "1" "1" "810" "92.9" "6.10" "3.73" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;other molecular function" "Pf00566" "7813" "ENSG00000067208" "EVI5" "A6NKX8; B9A6J0; hsa:7813; O60447; Q9H1Y9" "" "" "0" "0" "0.975" "0.656" "1.115" "1.096" "0.814" "0.986" "1.021" "0.776" "0.841" "66.7" "65.1" "43.8" "74.4" "73.1" "54.3" "65.8" "68.1" "51.7" "56.1" "" "" "" "" "" "" "" "" "" "" "66.7" "55.0" "27.7" "54.3" "59.9" "42.2" "50.7" "58.6" "40.4" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "4.025" "5" "1" "1" "1" "178" "19.2" "9.80" "3.59" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "0.960" "0.988" "1.061" "1.162" "0.974" "1.113" "1.015" "1.085" "1.053" "81.0" "77.7" "80.0" "86.0" "94.1" "78.9" "90.2" "82.2" "87.9" "85.3" "" "" "" "" "" "" "" "" "" "" "81.0" "65.8" "50.6" "62.7" "77.1" "61.3" "69.5" "70.7" "68.6" "76.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "4.023" "2" "1" "1" "1" "540" "59.1" "4.82" "3.06" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "11" "0" "0.959" "0.874" "0.974" "0.900" "1.038" "0.881" "0.840" "0.970" "1.012" "41.4" "39.7" "36.2" "40.3" "37.3" "43.0" "36.5" "34.8" "40.2" "41.9" "" "" "" "" "" "" "" "" "" "" "41.4" "33.6" "22.9" "29.4" "30.5" "33.4" "28.1" "29.9" "31.3" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "4.023" "4" "2" "2" "2" "457" "52.2" "6.55" "5.27" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "Synthesis of PC; Synthesis of PE" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2931302988534192752" "False" "High" "IsMasterProtein" "Q53QZ3" "Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2" "0.000" "False" "4.013" "2" "1" "1" "1" "475" "54.5" "9.39" "3.45" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "55843" "ENSG00000075884" "ARHGAP15" "hsa:55843; Q53QZ3; Q53R36; Q53RD7; Q53RT6; Q53SX9; Q584N9; Q6PJE6; Q86WP1; Q8IXX1; Q9NRL8; Q9NZ77; Q9NZ91" "Ectoderm differentiation; Ectoderm differentiation" "RAC1 GTPase cycle; RAC3 GTPase cycle" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "4.013" "6" "2" "2" "2" "231" "24.7" "7.23" "5.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "" "L1CAM interactions" "1" "0" "1.167" "0.964" "1.200" "1.131" "1.211" "1.210" "1.136" "1.451" "1.156" "87.5" "102.1" "84.3" "105.0" "99.0" "105.9" "105.8" "99.4" "126.9" "101.2" "" "" "" "" "" "" "" "" "" "" "87.5" "86.4" "53.3" "76.6" "81.1" "82.3" "81.6" "85.5" "99.1" "91.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5595867341215440863" "False" "High" "IsMasterProtein" "Q6ZU65" "Ubinuclein-2 OS=Homo sapiens OX=9606 GN=UBN2 PE=1 SV=2" "0.000" "False" "4.012" "1" "2" "2" "2" "1347" "146.0" "9.19" "5.64" "2" "" "nucleus" "" "Pf08729, Pf14075" "254048" "ENSG00000157741" "UBN2" "A4D1S2; hsa:254048; Q2YDY4; Q6P1K0; Q6ZU65; Q86XN9; Q8N7D1" "" "" "0" "0" "1.303" "1.116" "1.209" "1.442" "1.259" "1.362" "1.319" "1.012" "1.247" "31.4" "40.9" "35.0" "37.9" "45.2" "39.5" "42.7" "41.4" "31.7" "39.1" "" "" "" "" "" "" "" "" "" "" "31.4" "34.6" "22.1" "27.7" "37.1" "30.7" "32.9" "35.6" "24.8" "35.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "151514905296234920" "False" "High" "IsMasterProtein" "Q99759" "Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2" "0.000" "False" "4.012" "3" "2" "2" "1" "626" "70.9" "8.84" "2.47" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00564" "4215" "ENSG00000198909" "MAP3K3" "B2RCW2; D3DU15; hsa:4215; Q5BKZ6; Q8N3I9; Q99759" "IL-1 signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Pleural mesothelioma; GDNF signaling" "Interleukin-1 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841941710175491915" "False" "High" "IsMasterProtein" "Q5HYK3" "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2" "0.000" "False" "4.011" "6" "2" "2" "2" "327" "37.1" "6.95" "4.55" "2" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01209" "84274" "ENSG00000110871" "COQ5" "B2RDU9; B3GK62; B4DEJ4; hsa:84274; Q32Q28; Q53HH0; Q5HYK3; Q96LV1; Q9BSP8" "" "Ubiquinol biosynthesis" "1" "0" "1.102" "1.190" "0.994" "1.117" "1.022" "0.968" "0.899" "1.001" "1.070" "100.4" "110.6" "119.5" "99.8" "112.1" "102.6" "97.2" "90.3" "100.5" "107.4" "" "" "" "" "" "" "" "" "" "" "100.4" "93.6" "75.5" "72.8" "91.8" "79.7" "74.9" "77.6" "78.5" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "4.011" "3" "1" "2" "1" "338" "37.4" "6.98" "6.17" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1998394200407490675" "False" "High" "IsMasterProtein" "Q8WUA4" "General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2" "0.000" "False" "4.009" "2" "2" "2" "2" "911" "100.6" "7.31" "5.58" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00400" "2976" "ENSG00000115207" "GTF3C2" "D6W557; hsa:2976; Q16632; Q8WUA4; Q9BWI7" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.898" "0.910" "1.026" "0.996" "0.943" "0.905" "1.084" "0.777" "1.040" "89.9" "80.7" "81.8" "92.2" "89.6" "84.8" "81.4" "97.5" "69.9" "93.5" "" "" "" "" "" "" "" "" "" "" "89.9" "68.3" "51.7" "67.3" "73.4" "65.8" "62.7" "83.8" "54.5" "84.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4994086141420822230" "False" "High" "IsMasterProtein" "P02794" "Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2" "0.000" "False" "4.009" "9" "2" "3" "2" "183" "21.2" "5.55" "7.28" "2" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2495" "ENSG00000167996" "FTH1" "B3KNR5; hsa:2495; P02794; Q3KRA8; Q3SWW1" "Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "4.006" "3" "1" "1" "1" "307" "34.9" "9.57" "3.73" "1" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1532626323839813541" "False" "High" "IsMasterProtein" "Q99622" "Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1" "0.000" "False" "4.005" "12" "1" "1" "1" "126" "13.2" "5.14" "3.47" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf14974" "113246" "ENSG00000111678" "C12orf57" "B2R4Q6; hsa:113246; Q99622" "" "" "0" "0" "1.054" "0.785" "1.031" "1.172" "1.060" "1.140" "1.043" "0.926" "1.276" "52.1" "54.9" "40.9" "53.7" "61.1" "55.2" "59.4" "54.3" "48.3" "66.5" "" "" "" "" "" "" "" "" "" "" "52.1" "46.5" "25.9" "39.2" "50.0" "42.9" "45.8" "46.7" "37.7" "59.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "High" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.000" "False" "4.003" "5" "2" "2" "2" "353" "38.2" "4.59" "5.52" "2" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314583423527293992" "False" "High" "IsMasterProtein" "Q96SZ6" "Mitochondrial tRNA methylthiotransferase CDK5RAP1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2" "0.000" "False" "4.000" "2" "2" "2" "2" "601" "67.6" "8.21" "4.56" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00919, Pf01938, Pf04055" "51654" "ENSG00000101391" "CDK5RAP1" "A8K7R0; hsa:51654; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q96SZ6; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1179356982440791831" "False" "High" "IsMasterProtein" "Q6ZNW5" "GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2" "0.000" "False" "3.992" "5" "2" "2" "2" "385" "42.3" "6.47" "5.16" "2" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "" "390637" "ENSG00000183208" "GDPGP1" "hsa:390637; Q6ZNW5" "" "" "0" "0" "0.987" "0.903" "1.168" "1.062" "0.809" "1.127" "1.056" "1.033" "1.120" "41.7" "41.2" "37.7" "48.7" "44.3" "33.8" "47.0" "44.1" "43.1" "46.7" "" "" "" "" "" "" "" "" "" "" "41.7" "34.9" "23.8" "35.5" "36.3" "26.2" "36.3" "37.9" "33.6" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.000" "False" "3.988" "7" "2" "2" "2" "250" "29.4" "10.37" "3.12" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.114" "1.189" "1.167" "1.221" "1.080" "1.150" "1.149" "1.177" "1.096" "195.2" "217.3" "232.0" "227.7" "238.3" "210.9" "224.4" "224.2" "229.8" "213.9" "" "" "" "" "" "" "" "" "" "" "195.2" "183.9" "146.7" "166.0" "195.3" "163.8" "173.0" "192.8" "179.3" "192.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5570985190498897976" "False" "High" "IsMasterProtein" "P28676" "Grancalcin OS=Homo sapiens OX=9606 GN=GCA PE=1 SV=2" "0.000" "False" "3.987" "5" "1" "1" "1" "217" "24.0" "5.21" "3.30" "1" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202" "25801" "ENSG00000115271" "GCA" "B2R5X3; hsa:25801; P28676; Q53TB5; Q59EP3" "" "Neutrophil degranulation" "1" "0" "1.163" "1.010" "1.407" "1.068" "0.960" "1.194" "1.283" "1.335" "1.566" "29.9" "34.7" "30.2" "42.0" "31.9" "28.7" "35.7" "38.3" "39.9" "46.8" "" "" "" "" "" "" "" "" "" "" "29.9" "29.4" "19.1" "30.6" "26.1" "22.3" "27.5" "32.9" "31.1" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6562177240292846235" "False" "High" "IsMasterProtein" "Q99490" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=AGAP2 PE=1 SV=2" "0.000" "False" "3.986" "1" "1" "1" "1" "1192" "124.6" "9.89" "4.06" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf00071, Pf01412" "116986" "ENSG00000135439" "AGAP2" "A8K9F7; hsa:116986; O00578; Q548E0; Q8IWU3; Q99490" "Prolactin signaling pathway; Fragile X syndrome; Netrin-UNC5B signaling pathway; 15q25 copy number variation" "Netrin-1 signaling" "5" "0" "1.219" "0.769" "1.196" "1.169" "1.153" "1.304" "1.273" "0.805" "1.265" "23.6" "28.8" "18.2" "28.3" "27.6" "27.3" "30.8" "30.1" "19.0" "29.9" "" "" "" "" "" "" "" "" "" "" "23.6" "24.4" "11.5" "20.6" "22.6" "21.2" "23.8" "25.9" "14.9" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "3.986" "5" "1" "2" "1" "187" "20.8" "9.10" "4.86" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "3.982" "4" "2" "2" "2" "399" "44.3" "8.07" "5.21" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "35" "0" "1.093" "0.758" "1.058" "0.852" "0.745" "0.855" "0.916" "0.712" "0.961" "54.0" "59.0" "40.9" "57.1" "46.0" "40.2" "46.2" "49.4" "38.4" "51.9" "" "" "" "" "" "" "" "" "" "" "54.0" "49.9" "25.9" "41.7" "37.7" "31.2" "35.6" "42.5" "30.0" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097608289690062130" "False" "High" "IsMasterProtein" "P43250" "G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2" "0.000" "False" "3.982" "2" "1" "1" "1" "576" "65.9" "8.00" "3.18" "1" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2870" "ENSG00000198055" "GRK6" "hsa:2870; O60541; P43250; Q13652" "Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells; 5q35 copy number variation" "G alpha (s) signalling events" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "High" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.000" "False" "3.981" "2" "1" "1" "1" "940" "105.9" "8.90" "3.26" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "3.980" "8" "1" "1" "1" "150" "17.4" "5.67" "2.99" "1" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "6" "0" "1.154" "1.257" "1.041" "0.996" "0.998" "1.072" "1.117" "1.211" "1.216" "19.2" "22.1" "24.1" "20.0" "19.1" "19.1" "20.6" "21.4" "23.2" "23.3" "" "" "" "" "" "" "" "" "" "" "19.2" "18.7" "15.2" "14.6" "15.6" "14.9" "15.8" "18.4" "18.1" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "3.977" "1" "1" "1" "1" "670" "75.4" "9.50" "2.80" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.142" "1.158" "1.203" "0.935" "1.420" "0.799" "1.318" "1.315" "1.114" "30.4" "34.7" "35.2" "36.6" "28.4" "43.2" "24.3" "40.1" "40.0" "33.8" "" "" "" "" "" "" "" "" "" "" "30.4" "29.4" "22.3" "26.7" "23.3" "33.5" "18.7" "34.5" "31.2" "30.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2264903312611257722" "False" "High" "IsMasterProtein" "Q05469" "Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4" "0.000" "False" "3.974" "2" "2" "2" "2" "1076" "116.5" "6.70" "5.97" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf06350, Pf07859" "3991" "ENSG00000079435" "LIPE" "hsa:3991; Q05469; Q3LRT2; Q6NSL7" "AMP-activated protein kinase signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy" "Triglyceride catabolism" "11" "0" "1.006" "0.936" "0.897" "1.043" "1.047" "0.991" "1.065" "0.960" "0.942" "145.9" "146.7" "136.5" "130.8" "152.1" "152.7" "144.5" "155.4" "140.0" "137.4" "" "" "" "" "" "" "" "" "" "" "145.9" "124.1" "86.3" "95.4" "124.6" "118.6" "111.4" "133.6" "109.3" "123.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "3.967" "4" "1" "1" "1" "336" "35.3" "8.13" "4.02" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271257472643545210" "False" "High" "IsMasterProtein" "Q6PCE3" "Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3" "0.000" "False" "3.964" "3" "2" "2" "1" "622" "70.4" "7.15" "5.34" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf02878, Pf02879, Pf02880" "283209" "ENSG00000165434" "PGM2L1" "hsa:283209; Q6PCE3; Q96MQ7; Q9UIK3" "" "Glycolysis" "1" "0" "1.077" "1.184" "0.889" "1.120" "1.143" "1.000" "1.098" "1.082" "1.119" "113.0" "121.7" "133.8" "100.4" "126.6" "129.2" "113.0" "124.1" "122.2" "126.5" "" "" "" "" "" "" "" "" "" "" "113.0" "103.0" "84.6" "73.2" "103.7" "100.3" "87.1" "106.7" "95.4" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "3.959" "10" "1" "3" "1" "118" "12.6" "5.48" "8.94" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "32" "0" "1.062" "1.008" "1.086" "1.041" "1.052" "1.044" "0.996" "0.985" "0.980" "178.9" "189.9" "180.3" "194.2" "186.2" "188.2" "186.9" "178.1" "176.3" "175.4" "" "" "" "" "" "" "" "" "" "" "178.9" "160.7" "114.0" "141.6" "152.6" "146.2" "144.0" "153.2" "137.6" "157.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "3.953" "3" "1" "3" "1" "572" "61.8" "7.09" "11.68" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "" "CRMPs in Sema3A signaling" "1" "0" "1.035" "1.070" "1.163" "1.012" "1.033" "0.987" "1.009" "1.087" "1.083" "239.7" "248.1" "256.6" "278.7" "242.7" "247.6" "236.5" "242.0" "260.6" "259.7" "" "" "" "" "" "" "" "" "" "" "239.7" "209.9" "162.2" "203.2" "198.8" "192.3" "182.3" "208.0" "203.4" "233.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1655818240381757095" "False" "High" "IsMasterProtein" "Q9NSY1" "BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2" "0.000" "False" "3.953" "1" "1" "1" "1" "1161" "129.1" "6.51" "3.20" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf15282" "55589" "ENSG00000138756" "BMP2K" "hsa:55589; O94791; Q4W5H2; Q8IYF2; Q8N2G7; Q8NHG9; Q9NSY1; Q9NTG8" "" "" "0" "0" "0.978" "0.706" "1.044" "0.823" "1.007" "0.860" "0.854" "0.822" "0.940" "42.8" "41.8" "30.2" "44.6" "35.2" "43.0" "36.8" "36.5" "35.2" "40.2" "" "" "" "" "" "" "" "" "" "" "42.8" "35.4" "19.1" "32.6" "28.8" "33.4" "28.3" "31.4" "27.4" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-794247632168197847" "False" "High" "IsMasterProtein" "Q8NI37" "Protein phosphatase PTC7 homolog OS=Homo sapiens OX=9606 GN=PPTC7 PE=1 SV=1" "0.000" "False" "3.949" "5" "1" "1" "1" "304" "32.6" "5.19" "3.55" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf07228" "160760" "ENSG00000196850" "PPTC7" "B3KWC5; hsa:160760; Q68DZ7; Q6UY82; Q8NI37" "" "" "0" "0" "1.054" "0.966" "1.132" "1.239" "1.099" "1.074" "0.983" "1.027" "1.156" "55.4" "58.4" "53.5" "62.7" "68.6" "60.9" "59.5" "54.5" "56.9" "64.0" "" "" "" "" "" "" "" "" "" "" "55.4" "49.4" "33.8" "45.7" "56.2" "47.3" "45.9" "46.8" "44.4" "57.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "High" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.000" "False" "3.947" "1" "1" "1" "1" "1069" "121.3" "6.70" "3.28" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.116" "1.119" "1.121" "1.100" "1.187" "1.050" "1.067" "1.263" "1.046" "47.2" "52.7" "52.8" "52.9" "52.0" "56.1" "49.6" "50.4" "59.6" "49.4" "" "" "" "" "" "" "" "" "" "" "47.2" "44.6" "33.4" "38.6" "42.6" "43.5" "38.2" "43.3" "46.5" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4832953395278977218" "False" "High" "IsMasterProtein" "Q8NDZ2" "SUMO-interacting motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SIMC1 PE=1 SV=3" "0.000" "False" "3.944" "2" "1" "1" "1" "872" "96.8" "6.57" "2.87" "1" "" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "375484" "ENSG00000170085" "SIMC1" "F6R0L0; hsa:375484; J3KQQ8; Q6NXN8; Q6ZTU4; Q8IZ15; Q8NDZ2; R9TJD7" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256207077144686062" "False" "High" "IsMasterProtein" "Q9UK61" "Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3" "0.000" "False" "3.941" "1" "1" "1" "1" "1670" "188.9" "5.80" "2.28" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12509" "23272" "ENSG00000163946" "TASOR" "A1L3A4; B5ME28; hsa:23272; Q9H2F7; Q9UK61; Q9UPP7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "High" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.000" "False" "3.936" "7" "2" "2" "2" "214" "23.8" "5.68" "5.49" "2" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342285970436861386" "False" "High" "IsMasterProtein" "Q9UPM8" "AP-4 complex subunit epsilon-1 OS=Homo sapiens OX=9606 GN=AP4E1 PE=1 SV=2" "0.000" "False" "3.935" "1" "1" "1" "1" "1137" "127.2" "5.99" "2.80" "1" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf14807" "23431" "ENSG00000081014" "AP4E1" "A0AVD6; A1L4A9; A6NNX7; H0YKX4; hsa:23431; Q68D31; Q9UPM8; Q9Y588" "" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "2" "0" "0.987" "0.920" "1.231" "0.967" "1.015" "1.078" "0.698" "0.981" "0.896" "18.8" "18.6" "17.3" "23.2" "18.2" "19.1" "20.3" "13.1" "18.5" "16.9" "" "" "" "" "" "" "" "" "" "" "18.8" "15.7" "11.0" "16.9" "14.9" "14.8" "15.7" "11.3" "14.4" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "3.930" "3" "1" "1" "1" "322" "34.9" "6.44" "3.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "Exercise-induced circadian regulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.000" "False" "3.925" "11" "2" "2" "2" "142" "17.0" "6.18" "5.68" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "0.967" "1.119" "1.060" "1.092" "1.056" "1.141" "0.965" "1.008" "0.900" "107.0" "103.4" "119.7" "113.4" "116.8" "113.0" "122.0" "103.2" "107.8" "96.3" "" "" "" "" "" "" "" "" "" "" "107.0" "87.5" "75.7" "82.7" "95.7" "87.8" "94.1" "88.7" "84.2" "86.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1842086300853461210" "False" "High" "IsMasterProtein" "Q9ULL1" "Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens OX=9606 GN=PLEKHG1 PE=1 SV=2" "0.000" "False" "3.923" "1" "1" "2" "1" "1385" "155.3" "6.24" "3.06" "1" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "57480" "ENSG00000120278" "PLEKHG1" "hsa:57480; Q5T1F2; Q9ULL1" "Opioid receptor pathways" "CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.000" "False" "3.920" "11" "1" "1" "1" "90" "10.4" "8.72" "3.30" "1" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein import" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.000" "False" "3.916" "3" "1" "1" "1" "347" "40.1" "6.49" "3.96" "1" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "0.861" "0.657" "0.896" "0.656" "1.001" "0.773" "0.774" "0.924" "0.966" "43.6" "37.6" "28.7" "39.1" "28.6" "43.7" "33.7" "33.8" "40.3" "42.2" "" "" "" "" "" "" "" "" "" "" "43.6" "31.8" "18.1" "28.5" "23.5" "33.9" "26.0" "29.1" "31.5" "37.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "3.910" "7" "1" "1" "1" "196" "23.0" "7.39" "3.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "" "Unwinding of DNA" "1" "0" "1.092" "1.196" "1.189" "1.170" "1.246" "1.293" "1.229" "1.412" "1.294" "67.4" "73.6" "80.6" "80.1" "78.8" "83.9" "87.1" "82.8" "95.1" "87.2" "" "" "" "" "" "" "" "" "" "" "67.4" "62.3" "51.0" "58.4" "64.6" "65.2" "67.2" "71.2" "74.3" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677179923960499603" "False" "High" "IsMasterProtein" "Q86UD0" "Suppressor APC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SAPCD2 PE=1 SV=2" "0.000" "False" "3.906" "3" "1" "1" "1" "394" "42.6" "8.82" "3.40" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf11414" "89958" "ENSG00000186193" "SAPCD2" "hsa:89958; Q86UD0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1388162349834073741" "False" "High" "IsMasterProtein" "P31323" "cAMP-dependent protein kinase type II-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2B PE=1 SV=3" "0.000" "False" "3.906" "4" "2" "3" "2" "418" "46.3" "4.92" "5.00" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5577" "ENSG00000005249" "PRKAR2B" "A4D0R9; hsa:5577; P31323" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "High" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.000" "False" "3.906" "2" "1" "1" "1" "577" "65.9" "6.51" "3.42" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Cell cycle; G1 to S cell cycle control; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4393204020125526762" "False" "High" "IsMasterProtein" "O75164" "Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2" "0.000" "False" "3.904" "1" "1" "1" "1" "1064" "120.6" "5.85" "3.68" "1" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "9682" "ENSG00000066135" "KDM4A" "hsa:9682; O75164; Q5VVB1" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "3" "0" "0.971" "1.001" "1.057" "1.032" "1.034" "1.099" "1.173" "0.949" "0.960" "108.1" "105.0" "108.2" "114.3" "111.5" "111.8" "118.8" "126.8" "102.6" "103.8" "" "" "" "" "" "" "" "" "" "" "108.1" "88.8" "68.4" "83.3" "91.4" "86.8" "91.6" "109.0" "80.1" "93.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "3.893" "1" "2" "2" "2" "1531" "174.3" "8.72" "4.33" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "5" "0" "0.923" "1.064" "0.790" "1.133" "0.788" "0.761" "0.905" "0.887" "0.485" "15.4" "14.2" "16.4" "12.2" "17.4" "12.1" "11.7" "13.9" "13.7" "7.5" "" "" "" "" "" "" "" "" "" "" "15.4" "12.0" "10.4" "8.9" "14.3" "9.4" "9.0" "12.0" "10.7" "6.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1961832364316848105" "False" "High" "IsMasterProtein" "Q9NVM4" "Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1" "0.000" "False" "3.888" "4" "3" "3" "3" "692" "78.4" "5.57" "5.18" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf06325" "54496" "ENSG00000132600" "PRMT7" "B3KPR0; B3KUG9; B4E379; hsa:54496; Q96PV5; Q9H9L0; Q9NVM4" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038891551851932043" "False" "High" "IsMasterProtein" "Q6ZT07" "TBC1 domain family member 9 OS=Homo sapiens OX=9606 GN=TBC1D9 PE=1 SV=2" "0.000" "False" "3.883" "1" "1" "1" "1" "1266" "143.1" "5.31" "2.57" "1" "" "" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23158" "ENSG00000109436" "TBC1D9" "A6H8U8; D3DNZ1; hsa:23158; O94958; Q6ZT07" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1009047956554057166" "False" "High" "IsMasterProtein" "Q12756" "Kinesin-like protein KIF1A OS=Homo sapiens OX=9606 GN=KIF1A PE=1 SV=2" "0.000" "False" "3.882" "1" "2" "2" "1" "1690" "190.9" "6.21" "5.02" "2" "transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "547" "ENSG00000130294" "KIF1A" "B0I1S5; F5H045; hsa:547; O95068; Q12756; Q13355; Q14752; Q2NKJ6; Q4LE42; Q53T78; Q59GH1; Q63Z40; Q6P1R9; Q7KZ57" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "1.327" "1.532" "1.398" "1.507" "1.508" "1.779" "1.728" "1.782" "1.968" "38.9" "51.6" "59.6" "54.4" "58.6" "58.7" "69.2" "67.2" "69.3" "76.5" "" "" "" "" "" "" "" "" "" "" "38.9" "43.7" "37.7" "39.7" "48.0" "45.6" "53.3" "57.8" "54.1" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633091577178115671" "False" "High" "IsMasterProtein" "P41212" "Transcription factor ETV6 OS=Homo sapiens OX=9606 GN=ETV6 PE=1 SV=1" "0.000" "False" "3.882" "4" "2" "2" "2" "452" "53.0" "7.43" "4.81" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2120" "ENSG00000139083" "ETV6" "A3QVP6; A8K076; hsa:2120; P41212; Q9UMF6; Q9UMF7; Q9UMG0" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Exercise-induced circadian regulation" "Signaling by FLT3 fusion proteins; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "3.881" "4" "1" "1" "1" "309" "35.0" "4.60" "3.68" "1" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7321680242331923571" "False" "High" "IsMasterProtein" "Q96EI5" "Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2" "0.000" "False" "3.877" "4" "1" "1" "1" "215" "24.6" "5.20" "4.38" "1" "" "nucleus" "" "Pf04538" "79921" "ENSG00000133142" "TCEAL4" "hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "120688063892906197" "False" "High" "IsMasterProtein" "Q6P4R8" "Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2" "0.000" "False" "3.876" "2" "2" "2" "2" "1299" "138.9" "9.25" "5.78" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf14465" "4798" "ENSG00000170322" "NFRKB" "hsa:4798; Q12869; Q15312; Q6P4R8; Q9H048" "Overview of nanoparticle effects" "UCH proteinases; DNA Damage Recognition in GG-NER" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4221848423236778260" "False" "High" "IsMasterProtein" "Q14872" "Metal regulatory transcription factor 1 OS=Homo sapiens OX=9606 GN=MTF1 PE=1 SV=2" "0.000" "False" "3.872" "2" "1" "1" "1" "753" "80.9" "5.30" "2.71" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "4520" "ENSG00000188786" "MTF1" "B2RAK6; hsa:4520; Q14872; Q96CB1" "Copper homeostasis; Zinc homeostasis" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); MTF1 activates gene expression" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7004216377696589077" "False" "High" "IsMasterProtein" "Q96DC7" "Transmembrane and coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=TMCO6 PE=1 SV=2" "0.000" "False" "3.872" "2" "1" "1" "1" "493" "54.4" "5.81" "3.59" "1" "transport" "other membranes" "other molecular function" "" "55374" "ENSG00000113119" "TMCO6" "hsa:55374; Q96DC7; Q9BUU0; Q9P198" "" "" "0" "0" "0.466" "0.864" "1.164" "0.624" "1.028" "0.607" "0.947" "1.550" "1.682" "14.0" "6.5" "12.1" "16.3" "8.7" "14.4" "8.5" "13.3" "21.7" "23.6" "" "" "" "" "" "" "" "" "" "" "14.0" "5.5" "7.7" "11.9" "7.2" "11.2" "6.6" "11.4" "17.0" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5734018844191392129" "False" "High" "IsMasterProtein" "Q96EN9" "Required for excision 1-B domain-containing protein OS=Homo sapiens OX=9606 GN=REX1BD PE=1 SV=1" "0.000" "False" "3.870" "4" "1" "1" "1" "201" "22.6" "6.96" "2.73" "1" "" "" "" "Pf14966" "55049" "ENSG00000006015" "REX1BD" "E9PAS0; hsa:55049; Q8NAX4; Q96EN9; Q9NWI0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.000" "False" "3.868" "7" "2" "3" "1" "251" "28.1" "5.68" "9.44" "2" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "" "Trafficking of myristoylated proteins to the cilium" "1" "0" "0.804" "0.722" "0.908" "0.773" "0.679" "0.788" "0.746" "1.155" "0.806" "112.9" "90.7" "81.5" "102.5" "87.2" "76.6" "89.0" "84.1" "130.3" "91.0" "" "" "" "" "" "" "" "" "" "" "112.9" "76.7" "51.5" "74.8" "71.5" "59.5" "68.6" "72.3" "101.7" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325955711170823186" "False" "High" "IsMasterProtein" "Q9UIF9" "Bromodomain adjacent to zinc finger domain protein 2A OS=Homo sapiens OX=9606 GN=BAZ2A PE=1 SV=4" "0.000" "False" "3.867" "1" "2" "2" "2" "1905" "211.1" "6.64" "5.77" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01429, Pf02791, Pf15612, Pf15613" "11176" "ENSG00000076108" "BAZ2A" "B3KN66; hsa:11176; O00536; O15030; Q68DI8; Q96H26; Q9UIF9" "" "NoRC negatively regulates rRNA expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1635726356787300158" "False" "High" "IsMasterProtein" "Q7LDG7" "RAS guanyl-releasing protein 2 OS=Homo sapiens OX=9606 GN=RASGRP2 PE=1 SV=1" "0.000" "False" "3.866" "1" "1" "1" "1" "609" "69.2" "7.80" "3.79" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617, Pf00618, Pf13202" "10235" "ENSG00000068831" "RASGRP2" "A6NDC7; hsa:10235; O00538; Q7LDG7; Q9UL65" "MAPK signaling pathway; Chemokine signaling pathway; Ras signaling" "FCERI mediated NF-kB activation; Integrin signaling; Effects of PIP2 hydrolysis; Rap1 signalling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.000" "False" "3.865" "7" "1" "1" "1" "122" "14.3" "9.94" "3.20" "1" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "1.138" "1.030" "0.964" "0.994" "0.945" "0.960" "1.168" "1.200" "0.747" "45.4" "51.6" "46.7" "43.7" "45.1" "42.9" "43.5" "53.0" "54.4" "33.9" "" "" "" "" "" "" "" "" "" "" "45.4" "43.7" "29.6" "31.9" "36.9" "33.3" "33.6" "45.6" "42.5" "30.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.000" "False" "3.863" "1" "1" "1" "1" "1229" "125.0" "10.37" "2.84" "1" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622425969869744688" "False" "High" "IsMasterProtein" "Q9H4M3" "F-box only protein 44 OS=Homo sapiens OX=9606 GN=FBXO44 PE=1 SV=3" "0.000" "False" "3.862" "6" "1" "1" "1" "255" "29.7" "5.82" "3.34" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf04300, Pf12937" "93611" "ENSG00000132879" "FBXO44" "B3KNZ2; B7Z743; hsa:93611; Q5TGX2; Q5TGX4; Q5TGX5; Q68DJ9; Q8WWY2; Q9H4M3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8108900187098047619" "False" "High" "IsMasterProtein" "Q9H6U6" "BCAS3 microtubule associated cell migration factor OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3" "0.000" "False" "3.859" "1" "1" "1" "1" "928" "101.2" "6.70" "2.83" "1" "cell-cell signaling;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12490, Pf21034" "54828" "ENSG00000141376" "BCAS3" "hsa:54828; Q17RM0; Q6KF21; Q8IXI6; Q8NDR8; Q8TDL9; Q8TDM1; Q8WY55; Q9BVF0; Q9H6U6; Q9H957; Q9H9Y9; Q9NXP4" "Ectoderm differentiation" "" "1" "0" "1.078" "1.152" "0.994" "1.190" "1.079" "1.186" "1.167" "1.102" "1.179" "48.3" "52.1" "55.7" "48.0" "57.5" "52.2" "57.3" "56.4" "53.3" "57.0" "" "" "" "" "" "" "" "" "" "" "48.3" "44.1" "35.2" "35.0" "47.1" "40.5" "44.2" "48.5" "41.6" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298882931648225908" "False" "High" "IsMasterProtein" "Q9UGJ1" "Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1" "0.000" "False" "3.852" "2" "1" "1" "1" "667" "76.0" "6.65" "3.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cytoplasmic organelle" "cytoskeletal activity" "Pf04130, Pf17681" "27229" "ENSG00000137822" "TUBGCP4" "B3KNK6; hsa:27229; Q969X3; Q9NVF0; Q9UGJ1" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660069339337031106" "False" "High" "IsMasterProtein" "Q5T1R4" "Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=1 SV=1" "0.000" "False" "3.850" "0" "1" "1" "1" "2406" "259.3" "7.81" "3.75" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "59269" "ENSG00000127124" "HIVEP3" "A7YY91; hsa:59269; Q5T1R4; Q5T1R5; Q9BZS0; Q9HCL7" "" "Regulation of RUNX2 expression and activity" "1" "0" "0.951" "0.839" "0.967" "0.897" "0.810" "1.143" "0.926" "0.871" "0.843" "57.8" "55.0" "48.5" "55.9" "51.9" "46.9" "66.1" "53.6" "50.4" "48.7" "" "" "" "" "" "" "" "" "" "" "57.8" "46.6" "30.7" "40.8" "42.5" "36.4" "51.0" "46.1" "39.3" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "3.848" "3" "1" "1" "1" "571" "60.6" "6.54" "3.06" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "Ovarian tumor domain proteases; Negative regulators of DDX58/IFIH1 signaling" "4" "0" "1.271" "1.037" "1.377" "1.265" "0.939" "1.357" "1.312" "0.845" "1.180" "30.9" "39.3" "32.1" "42.6" "39.1" "29.0" "42.0" "40.6" "26.1" "36.5" "" "" "" "" "" "" "" "" "" "" "30.9" "33.3" "20.3" "31.0" "32.1" "22.5" "32.4" "34.9" "20.4" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "3.843" "5" "2" "3" "1" "286" "33.7" "9.36" "6.12" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "" "RHOJ GTPase cycle; RHOH GTPase cycle" "2" "0" "0.978" "0.982" "0.927" "0.990" "1.060" "1.005" "0.934" "0.999" "0.998" "268.0" "262.2" "263.3" "248.4" "265.4" "284.1" "269.4" "250.3" "267.7" "267.4" "" "" "" "" "" "" "" "" "" "" "268.0" "221.8" "166.5" "181.1" "217.5" "220.7" "207.6" "215.2" "209.0" "240.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "High" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.000" "False" "3.842" "4" "2" "2" "2" "350" "40.2" "6.60" "5.22" "2" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "3.839" "2" "1" "1" "1" "623" "71.3" "5.62" "3.61" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "0.933" "0.865" "1.150" "1.049" "0.995" "1.090" "1.030" "1.085" "1.033" "97.2" "90.6" "84.0" "111.7" "101.9" "96.6" "105.8" "100.1" "105.4" "100.3" "" "" "" "" "" "" "" "" "" "" "97.2" "76.7" "53.1" "81.5" "83.5" "75.0" "81.6" "86.0" "82.3" "90.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.000" "False" "3.821" "3" "1" "1" "1" "388" "40.4" "6.90" "3.09" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "0" "0.983" "1.021" "1.208" "0.947" "1.072" "0.882" "1.097" "1.043" "0.996" "83.2" "81.7" "84.9" "100.5" "78.7" "89.1" "73.4" "91.2" "86.8" "82.8" "" "" "" "" "" "" "" "" "" "" "83.2" "69.2" "53.7" "73.3" "64.5" "69.2" "56.6" "78.4" "67.7" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8151909637929937359" "False" "High" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "0.000" "False" "3.820" "3" "1" "1" "1" "519" "59.6" "7.91" "2.27" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "" "XBP1(S) activates chaperone genes" "1" "0" "1.227" "0.845" "1.299" "1.123" "0.887" "0.710" "0.872" "0.942" "1.013" "19.7" "24.2" "16.7" "25.6" "22.1" "17.5" "14.0" "17.2" "18.6" "20.0" "" "" "" "" "" "" "" "" "" "" "19.7" "20.5" "10.5" "18.7" "18.1" "13.6" "10.8" "14.8" "14.5" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3423051625263553233" "False" "High" "IsMasterProtein" "Q9BZQ6" "ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2" "0.000" "False" "3.816" "2" "2" "4" "2" "932" "104.6" "4.93" "7.47" "2" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi" "other molecular function" "Pf01532, Pf02225" "80267" "ENSG00000116406" "EDEM3" "B2RCH6; B7ZLZ2; hsa:80267; Q0VGM5; Q5TEZ0; Q7L2Y5; Q9BZQ6; Q9HCW1; Q9UFV7" "" "ER Quality Control Compartment (ERQC)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.000" "False" "3.808" "7" "2" "2" "2" "246" "27.4" "9.50" "4.39" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "3.805" "13" "2" "3" "2" "114" "13.5" "5.11" "9.45" "2" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "" "2" "0" "0.903" "0.873" "0.884" "0.848" "0.846" "0.948" "0.866" "0.767" "0.818" "528.3" "477.0" "461.3" "466.9" "448.1" "447.0" "500.7" "457.3" "405.4" "432.1" "" "" "" "" "" "" "" "" "" "" "528.3" "403.6" "291.7" "340.4" "367.1" "347.1" "386.0" "393.2" "316.5" "388.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "3.800" "3" "1" "1" "1" "345" "38.8" "7.81" "2.88" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Androgen receptor signaling pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.891" "0.826" "0.996" "1.060" "1.109" "0.956" "1.014" "0.963" "0.969" "149.8" "133.4" "123.8" "149.1" "158.7" "166.1" "143.1" "151.8" "144.1" "145.2" "" "" "" "" "" "" "" "" "" "" "149.8" "112.9" "78.3" "108.7" "130.0" "129.0" "110.3" "130.5" "112.5" "130.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6648624995345891134" "False" "High" "IsMasterProtein" "Q96T23" "Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2" "0.000" "False" "3.800" "1" "2" "2" "2" "1441" "163.7" "5.01" "5.07" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628, Pf15612" "51773" "ENSG00000048649" "RSF1" "hsa:51773; Q86X86; Q96T23; Q9H3L8; Q9NVZ8; Q9NYU0" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "1.047" "1.481" "1.045" "0.999" "1.434" "1.137" "1.143" "1.401" "1.069" "215.9" "226.0" "319.7" "225.5" "215.6" "309.5" "245.5" "246.8" "302.4" "230.8" "" "" "" "" "" "" "" "" "" "" "215.9" "191.2" "202.2" "164.4" "176.6" "240.3" "189.2" "212.2" "236.1" "207.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1078046361948541096" "False" "High" "IsMasterProtein" "Q6UWP2" "Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1" "0.000" "False" "3.796" "4" "1" "1" "1" "260" "28.3" "6.64" "3.10" "1" "other metabolic processes" "non-structural extracellular" "other molecular function" "Pf00106" "79154" "ENSG00000275397; ENSG00000278535" "DHRS11" "A0A0U5BLD0; B2RDZ3; hsa:79154; Q6UWP2; Q9BUC7; Q9H674" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "3.791" "3" "1" "1" "1" "421" "47.7" "8.03" "3.35" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "" "tRNA modification in the mitochondrion" "1" "0" "1.111" "1.190" "1.369" "1.044" "1.041" "1.127" "0.902" "0.925" "1.042" "56.2" "62.5" "66.9" "76.9" "58.7" "58.5" "63.3" "50.7" "52.0" "58.6" "" "" "" "" "" "" "" "" "" "" "56.2" "52.8" "42.3" "56.1" "48.1" "45.4" "48.8" "43.6" "40.6" "52.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.000" "False" "3.782" "3" "1" "1" "1" "376" "42.2" "6.74" "3.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "DNA repair pathways, full network" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "12" "0" "1.255" "0.928" "1.205" "1.034" "0.896" "1.107" "1.044" "1.033" "1.152" "61.7" "77.4" "57.2" "74.3" "63.7" "55.2" "68.2" "64.4" "63.7" "71.0" "" "" "" "" "" "" "" "" "" "" "61.7" "65.4" "36.2" "54.2" "52.2" "42.9" "52.6" "55.3" "49.7" "63.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403198551536365946" "False" "High" "IsMasterProtein" "Q14692" "Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1" "0.000" "False" "3.781" "1" "1" "1" "1" "1282" "145.7" "6.44" "3.43" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "9790" "ENSG00000165733" "BMS1" "hsa:9790; Q14692; Q5QPT5; Q86XJ9" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.998" "1.287" "1.007" "1.315" "1.396" "1.297" "1.165" "1.203" "1.135" "35.3" "35.2" "45.4" "35.5" "46.4" "49.2" "45.8" "41.1" "42.4" "40.1" "" "" "" "" "" "" "" "" "" "" "35.3" "29.8" "28.7" "25.9" "38.0" "38.2" "35.3" "35.3" "33.1" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200249932545446703" "False" "High" "IsMasterProtein" "Q6ZN55" "Zinc finger protein 574 OS=Homo sapiens OX=9606 GN=ZNF574 PE=1 SV=2" "0.000" "False" "3.781" "1" "1" "1" "1" "896" "98.8" "8.07" "3.04" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf13912" "64763" "ENSG00000105732" "ZNF574" "hsa:64763; Q6IPE0; Q6ZN10; Q6ZN55; Q7L5Z5; Q8NCE3; Q9H6N0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.000" "False" "3.779" "1" "1" "1" "1" "918" "105.4" "9.44" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "" "SUMOylation of DNA replication proteins; RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.224" "2.896" "1.271" "1.214" "3.227" "1.272" "1.043" "4.032" "1.427" "18.4" "22.5" "53.2" "23.4" "22.3" "59.3" "23.4" "19.2" "74.1" "26.2" "" "" "" "" "" "" "" "" "" "" "18.4" "19.0" "33.6" "17.0" "18.3" "46.1" "18.0" "16.5" "57.8" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "High" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.000" "False" "3.770" "2" "2" "2" "2" "928" "103.9" "8.05" "5.06" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "5" "0" "0.937" "0.820" "0.852" "0.877" "0.647" "0.917" "0.798" "0.769" "0.867" "38.7" "36.2" "31.7" "32.9" "33.9" "25.0" "35.4" "30.9" "29.8" "33.5" "" "" "" "" "" "" "" "" "" "" "38.7" "30.6" "20.1" "24.0" "27.8" "19.4" "27.3" "26.5" "23.2" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.000" "False" "3.770" "3" "2" "3" "1" "879" "100.8" "5.52" "8.05" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "3.755" "9" "1" "1" "1" "90" "9.4" "9.99" "2.75" "1" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.761" "2.043" "1.697" "1.590" "1.921" "1.217" "0.937" "1.770" "2.186" "67.3" "118.5" "137.4" "114.2" "107.0" "129.2" "81.9" "63.0" "119.0" "147.0" "" "" "" "" "" "" "" "" "" "" "67.3" "100.2" "86.9" "83.2" "87.6" "100.3" "63.1" "54.2" "92.9" "132.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "3.754" "2" "1" "1" "1" "417" "44.9" "8.75" "3.41" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "" "Neutrophil degranulation" "1" "0" "1.079" "0.992" "0.978" "0.960" "1.308" "1.151" "1.035" "1.040" "0.869" "61.1" "65.9" "60.6" "59.7" "58.7" "79.9" "70.3" "63.2" "63.5" "53.1" "" "" "" "" "" "" "" "" "" "" "61.1" "55.8" "38.3" "43.6" "48.1" "62.1" "54.2" "54.4" "49.6" "47.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.000" "False" "3.754" "2" "1" "1" "1" "621" "71.9" "7.66" "3.88" "1" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1970513305898255231" "False" "High" "IsMasterProtein" "Q9H2D6" "TRIO and F-actin-binding protein OS=Homo sapiens OX=9606 GN=TRIOBP PE=1 SV=3" "0.000" "False" "3.751" "1" "2" "2" "2" "2365" "261.2" "8.48" "5.48" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169" "11078" "ENSG00000100106" "TRIOBP" "B1AHD4; B1AHD7; F2Z2W0; F8W6V6; hsa:11078; O94797; Q2PZW8; Q2Q3Z9; Q2Q400; Q5R3M6; Q96DW1; Q9BT77; Q9BTL7; Q9BY98; Q9H2D6; Q9Y3L4" "" "" "0" "0" "1.147" "1.176" "1.420" "1.546" "1.372" "1.365" "1.367" "1.348" "1.083" "61.1" "70.1" "71.9" "86.8" "94.5" "83.8" "83.5" "83.6" "82.4" "66.2" "" "" "" "" "" "" "" "" "" "" "61.1" "59.3" "45.5" "63.3" "77.4" "65.1" "64.3" "71.9" "64.3" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "3.747" "2" "1" "1" "1" "595" "69.6" "6.47" "2.99" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "10" "0" "1.056" "1.001" "1.142" "0.918" "1.159" "1.129" "1.244" "1.189" "0.777" "24.0" "25.4" "24.0" "27.4" "22.0" "27.8" "27.1" "29.9" "28.5" "18.7" "" "" "" "" "" "" "" "" "" "" "24.0" "21.5" "15.2" "20.0" "18.1" "21.6" "20.9" "25.7" "22.3" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708904731044144793" "False" "High" "IsMasterProtein" "Q7Z3K6" "Mesoderm induction early response protein 3 OS=Homo sapiens OX=9606 GN=MIER3 PE=1 SV=2" "0.000" "False" "3.745" "2" "1" "1" "1" "550" "61.4" "4.51" "2.35" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "166968" "ENSG00000155545" "MIER3" "B4DRI9; B8ZZQ0; hsa:166968; Q5CZI0; Q68CS3; Q6MZS7; Q7Z3K6; Q86YG8; Q8NA13" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6790579379401263319" "False" "High" "IsMasterProtein" "Q8IU85" "Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1" "0.000" "False" "3.740" "2" "1" "1" "1" "385" "42.9" "7.21" "2.96" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "57118" "ENSG00000183049" "CAMK1D" "B0YIY0; hsa:57118; Q8IU85; Q9HD31" "" "" "0" "0" "1.143" "1.135" "1.154" "1.126" "1.135" "1.110" "1.078" "1.155" "1.136" "78.8" "90.0" "89.4" "91.0" "88.7" "89.4" "87.4" "84.9" "91.0" "89.5" "" "" "" "" "" "" "" "" "" "" "78.8" "76.2" "56.6" "66.3" "72.7" "69.5" "67.4" "73.0" "71.0" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697558618654746564" "False" "High" "IsMasterProtein" "Q92546" "RAB6A-GEF complex partner protein 2 OS=Homo sapiens OX=9606 GN=RGP1 PE=1 SV=1" "0.000" "False" "3.735" "3" "1" "1" "1" "391" "42.4" "5.96" "3.33" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf08737" "9827" "ENSG00000107185" "RGP1" "hsa:9827; Q5TCV5; Q92546" "" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5221985020490519737" "False" "High" "IsMasterProtein" "Q6PJI9" "GATOR2 complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "0.000" "False" "3.734" "2" "2" "2" "2" "974" "109.7" "7.91" "5.37" "2" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "" "Amino acids regulate mTORC1" "1" "0" "0.879" "0.852" "0.876" "0.967" "1.007" "0.847" "1.052" "0.810" "1.000" "48.6" "42.7" "41.4" "42.6" "47.0" "48.9" "41.1" "51.1" "39.3" "48.6" "" "" "" "" "" "" "" "" "" "" "48.6" "36.1" "26.1" "31.0" "38.5" "38.0" "31.7" "43.9" "30.7" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904247061824975509" "False" "High" "IsMasterProtein" "Q9NP73" "UDP-N-acetylglucosamine transferase subunit ALG13 OS=Homo sapiens OX=9606 GN=ALG13 PE=1 SV=2" "0.000" "False" "3.729" "1" "1" "2" "1" "1137" "126.0" "6.74" "6.28" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02338, Pf04101" "79868" "ENSG00000101901" "ALG13" "B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; B7ZAJ1; B7ZB57; hsa:79868; Q17RC3; Q5JXY9; Q9H5U8; Q9NP73" "N-glycan biosynthesis" "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS" "3" "0" "0.936" "1.147" "0.928" "1.147" "1.204" "1.201" "1.151" "0.897" "1.125" "68.5" "64.1" "78.6" "63.6" "78.6" "82.5" "82.3" "78.8" "61.4" "77.0" "" "" "" "" "" "" "" "" "" "" "68.5" "54.3" "49.7" "46.4" "64.4" "64.0" "63.4" "67.8" "48.0" "69.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4213076317646871579" "False" "High" "IsMasterProtein" "P16219" "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADS PE=1 SV=1" "0.000" "False" "3.726" "3" "1" "1" "1" "412" "44.3" "7.99" "3.04" "1" "other metabolic processes" "cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "35" "ENSG00000122971" "ACADS" "hsa:35; P16219; P78331" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101695172236042640" "False" "High" "IsMasterProtein" "P82921" "Small ribosomal subunit protein bS21m OS=Homo sapiens OX=9606 GN=MRPS21 PE=1 SV=3" "0.000" "False" "3.713" "24" "2" "4" "2" "87" "10.7" "9.92" "7.58" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01165" "54460" "ENSG00000266472" "MRPS21" "A0A075B746; hsa:54460; P82921; Q5TB11; Q9BST6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.083" "1.003" "1.049" "1.108" "0.935" "1.136" "1.274" "1.057" "0.925" "66.4" "71.9" "66.6" "69.7" "73.6" "62.1" "75.5" "84.6" "70.2" "61.4" "" "" "" "" "" "" "" "" "" "" "66.4" "60.9" "42.1" "50.8" "60.3" "48.2" "58.2" "72.8" "54.8" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1940412608894295944" "False" "High" "IsMasterProtein" "Q6P9B6" "MTOR-associated protein MEAK7 OS=Homo sapiens OX=9606 GN=MEAK7 PE=1 SV=2" "0.000" "False" "3.707" "3" "1" "1" "1" "456" "51.0" "6.24" "3.68" "1" "signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07534" "57707" "ENSG00000140950" "MEAK7" "hsa:57707; Q6P9B6; Q8IZ64; Q9HCG3; Q9NTE8" "" "" "0" "0" "0.984" "0.921" "1.227" "1.281" "1.009" "1.160" "1.053" "1.711" "0.898" "22.8" "22.5" "21.0" "28.0" "29.3" "23.1" "26.5" "24.0" "39.1" "20.5" "" "" "" "" "" "" "" "" "" "" "22.8" "19.0" "13.3" "20.4" "24.0" "17.9" "20.4" "20.7" "30.5" "18.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444310123710857374" "False" "High" "IsMasterProtein" "Q9Y2Y9" "Krueppel-like factor 13 OS=Homo sapiens OX=9606 GN=KLF13 PE=1 SV=1" "0.000" "False" "3.707" "7" "1" "1" "1" "288" "31.2" "9.54" "3.66" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "51621" "ENSG00000169926; ENSG00000275746" "KLF13" "hsa:51621; Q9Y2Y9; Q9Y356" "15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "" "2" "0" "0.966" "1.122" "1.115" "1.365" "1.208" "1.335" "1.423" "1.261" "0.958" "21.2" "20.5" "23.7" "23.6" "28.9" "25.6" "28.3" "30.1" "26.7" "20.3" "" "" "" "" "" "" "" "" "" "" "21.2" "17.3" "15.0" "17.2" "23.7" "19.9" "21.8" "25.9" "20.8" "18.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6884862282451345768" "False" "High" "IsMasterProtein" "Q9Y232" "Chromodomain Y-like protein OS=Homo sapiens OX=9606 GN=CDYL PE=1 SV=2" "0.000" "False" "3.703" "2" "1" "1" "1" "598" "66.4" "9.45" "2.73" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00378, Pf00385" "9425" "ENSG00000153046" "CDYL" "A8K6D6; B4DLG4; hsa:9425; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y232; Q9Y424" "" "" "0" "0" "1.000" "1.282" "0.849" "0.970" "1.232" "1.094" "0.858" "1.118" "0.993" "52.9" "52.8" "67.8" "44.9" "51.3" "65.1" "57.8" "45.3" "59.1" "52.5" "" "" "" "" "" "" "" "" "" "" "52.9" "44.7" "42.9" "32.7" "42.0" "50.6" "44.6" "39.0" "46.1" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "High" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.000" "False" "3.702" "5" "1" "1" "1" "287" "30.5" "6.79" "3.03" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4955977949004154122" "False" "High" "IsMasterProtein" "Q9NRW3" "DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2" "0.000" "False" "3.702" "7" "1" "1" "1" "190" "22.8" "7.59" "2.60" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf18782" "27350" "ENSG00000244509" "APOBEC3C" "B2R884; hsa:27350; Q5JZ92; Q7Z2N7; Q96F12; Q9NRW3" "" "Formation of the Editosome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "3.700" "5" "2" "3" "2" "289" "31.4" "7.36" "7.79" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446156853799225344" "False" "High" "IsMasterProtein" "Q9C0D2" "Centrosomal protein of 295 kDa OS=Homo sapiens OX=9606 GN=CEP295 PE=1 SV=4" "0.001" "False" "3.697" "0" "2" "3" "1" "2601" "295.0" "6.00" "8.57" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309" "85459" "ENSG00000166004" "CEP295" "C9J5H9; C9JQY8; hsa:85459; Q8N7L4; Q8N919; Q8N9B0; Q96LT8; Q9C0D2" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.001" "False" "3.696" "12" "1" "2" "1" "73" "8.5" "8.44" "5.70" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.054" "0.727" "1.106" "1.003" "0.681" "1.166" "0.950" "0.675" "0.920" "149.1" "157.2" "108.4" "164.8" "149.6" "101.5" "173.8" "141.7" "100.7" "137.1" "" "" "" "" "" "" "" "" "" "" "149.1" "133.0" "68.5" "120.2" "122.6" "78.9" "134.0" "121.8" "78.6" "123.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3067082233610559279" "False" "High" "IsMasterProtein" "Q9Y639" "Neuroplastin OS=Homo sapiens OX=9606 GN=NPTN PE=1 SV=2" "0.001" "False" "3.695" "3" "1" "1" "1" "398" "44.4" "7.99" "2.28" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13927" "27020" "ENSG00000156642" "NPTN" "B2RAL7; B7Z4D3; B7ZLL2; hsa:27020; Q17R52; Q59EJ9; Q6NVX7; Q9Y639; Q9Y640" "" "GABA receptor activation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.001" "False" "3.694" "2" "1" "1" "1" "437" "48.7" "5.82" "3.09" "1" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3182776734112552640" "False" "High" "IsMasterProtein" "P41279" "Mitogen-activated protein kinase kinase kinase 8 OS=Homo sapiens OX=9606 GN=MAP3K8 PE=1 SV=2" "0.001" "False" "3.692" "2" "1" "1" "1" "467" "52.9" "5.81" "3.36" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00069" "1326" "ENSG00000107968" "MAP3K8" "A8K2Q5; D3DRX1; hsa:1326; P41279; Q14275; Q5T855; Q9HC81" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "CD28 dependent PI3K/Akt signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3703559118083168088" "False" "High" "IsMasterProtein" "Q8N5H7" "SH2 domain-containing protein 3C OS=Homo sapiens OX=9606 GN=SH2D3C PE=1 SV=1" "0.001" "False" "3.691" "1" "1" "1" "1" "860" "94.4" "8.07" "3.07" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00617" "10044" "ENSG00000095370" "SH2D3C" "A8K5S8; E9PG48; hsa:10044; Q5HYE5; Q5JU31; Q6UY42; Q8N5H7; Q8N6X3; Q9Y2X5" "" "" "0" "0" "1.003" "0.836" "0.925" "1.197" "0.892" "1.378" "1.125" "0.957" "0.996" "50.3" "50.5" "42.1" "46.6" "60.3" "44.9" "69.4" "56.6" "48.1" "50.2" "" "" "" "" "" "" "" "" "" "" "50.3" "42.7" "26.6" "34.0" "49.4" "34.9" "53.5" "48.7" "37.6" "45.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1426220521717518042" "False" "High" "IsMasterProtein" "Q9BYH8" "NF-kappa-B inhibitor zeta OS=Homo sapiens OX=9606 GN=NFKBIZ PE=1 SV=1" "0.001" "False" "3.691" "1" "1" "1" "1" "718" "78.0" "6.62" "2.59" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12796" "64332" "ENSG00000144802" "NFKBIZ" "B3KNR2; D3DN54; hsa:64332; Q8IUL4; Q8NAZ8; Q9BYH8" "IL-18 signaling pathway; Burn wound healing" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "High" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.001" "False" "3.687" "2" "1" "1" "1" "338" "36.3" "7.96" "3.71" "1" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Modulators of TCR signaling and T cell activation" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "2" "0" "1.074" "1.098" "1.132" "1.242" "1.120" "1.187" "1.225" "1.101" "0.921" "133.8" "143.7" "146.8" "151.5" "166.1" "149.8" "158.8" "163.9" "147.3" "123.2" "" "" "" "" "" "" "" "" "" "" "133.8" "121.6" "92.9" "110.4" "136.1" "116.4" "122.4" "140.9" "115.0" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.001" "False" "3.679" "2" "1" "1" "1" "496" "53.3" "7.77" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "5q35 copy number variation" "Neutrophil degranulation" "2" "0" "0.952" "1.026" "0.868" "0.940" "1.020" "0.884" "0.968" "0.955" "0.928" "120.1" "114.3" "123.3" "104.2" "113.0" "122.6" "106.2" "116.3" "114.8" "111.5" "" "" "" "" "" "" "" "" "" "" "120.1" "96.7" "77.9" "76.0" "92.5" "95.2" "81.9" "100.0" "89.6" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7531321553929023079" "False" "High" "IsMasterProtein" "Q69YI7" "Nuclear apoptosis-inducing factor 1 OS=Homo sapiens OX=9606 GN=NAIF1 PE=1 SV=1" "0.001" "False" "3.679" "3" "1" "1" "1" "327" "35.1" "7.21" "2.51" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus" "" "Pf13873" "203245" "ENSG00000171169" "NAIF1" "B3KV81; hsa:203245; Q69YI7; Q8WU12" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8839545620378570956" "False" "High" "IsMasterProtein" "Q9NRR6" "Phosphatidylinositol polyphosphate 5-phosphatase type IV OS=Homo sapiens OX=9606 GN=INPP5E PE=1 SV=2" "0.001" "False" "3.677" "1" "1" "1" "1" "644" "70.2" "8.95" "2.22" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "" "56623" "ENSG00000148384" "INPP5E" "hsa:56623; Q15734; Q6PIV5; Q9NRR6" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Synthesis of PIPs at the Golgi membrane; ARL13B-mediated ciliary trafficking of INPP5E" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.001" "False" "3.669" "6" "1" "1" "1" "191" "21.9" "5.40" "4.41" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "Epithelial to mesenchymal transition in colorectal cancer" "" "1" "0" "1.193" "1.100" "1.091" "1.144" "1.306" "1.003" "1.246" "1.126" "1.210" "32.2" "38.5" "35.5" "35.2" "36.9" "42.1" "32.3" "40.2" "36.3" "39.0" "" "" "" "" "" "" "" "" "" "" "32.2" "32.5" "22.4" "25.7" "30.2" "32.7" "24.9" "34.5" "28.3" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.001" "False" "3.669" "4" "2" "2" "2" "356" "40.0" "7.05" "5.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "" "Neutrophil degranulation; RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.046" "0.845" "0.923" "0.871" "1.015" "0.847" "1.025" "0.820" "0.881" "77.3" "80.9" "65.3" "71.4" "67.3" "78.5" "65.5" "79.2" "63.4" "68.1" "" "" "" "" "" "" "" "" "" "" "77.3" "68.4" "41.3" "52.0" "55.2" "60.9" "50.5" "68.1" "49.5" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4019435844159720202" "False" "High" "IsMasterProtein" "P84074" "Neuron-specific calcium-binding protein hippocalcin OS=Homo sapiens OX=9606 GN=HPCA PE=1 SV=2" "0.001" "False" "3.663" "10" "2" "2" "2" "193" "22.4" "4.97" "5.28" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf13499" "3208" "ENSG00000121905" "HPCA" "B2R9T3; D3DPQ7; hsa:3208; P32076; P41211; P70510; P84074" "Opioid receptor pathways" "" "1" "0" "0.978" "0.799" "1.229" "1.386" "0.985" "0.962" "0.919" "1.041" "0.984" "32.8" "32.1" "26.2" "40.3" "45.4" "32.3" "31.5" "30.1" "34.1" "32.3" "" "" "" "" "" "" "" "" "" "" "32.8" "27.1" "16.6" "29.4" "37.2" "25.1" "24.3" "25.9" "26.7" "29.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3136372525851950601" "False" "High" "IsMasterProtein" "P0C7T5" "Ataxin-1-like OS=Homo sapiens OX=9606 GN=ATXN1L PE=1 SV=1" "0.001" "False" "3.663" "2" "1" "1" "1" "689" "73.3" "6.60" "2.34" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08517, Pf12547" "342371" "ENSG00000224470" "ATXN1L" "hsa:342371; P0C7T5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1059597510691601" "False" "High" "IsMasterProtein" "B2RBV5" "MORF4 family associated protein 1 like 2 OS=Homo sapiens OX=9606 GN=MRFAP1L2 PE=1 SV=1" "0.001" "False" "3.658" "7" "1" "1" "1" "119" "13.4" "8.22" "3.17" "1" "other biological processes" "" "" "Pf15155" "" "" "MRFAP1L2" "B2RBV5" "" "" "0" "0" "0.992" "0.874" "1.094" "0.986" "0.788" "1.154" "0.978" "0.762" "0.768" "84.3" "83.6" "73.7" "92.2" "83.1" "66.5" "97.3" "82.5" "64.2" "64.8" "" "" "" "" "" "" "" "" "" "" "84.3" "70.8" "46.6" "67.3" "68.1" "51.6" "75.0" "70.9" "50.1" "58.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.001" "False" "3.655" "2" "2" "2" "2" "603" "69.9" "8.18" "4.82" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.138" "1.184" "1.240" "1.128" "1.214" "1.140" "1.211" "1.308" "1.125" "233.5" "265.6" "276.5" "289.4" "263.3" "283.5" "266.1" "282.8" "305.3" "262.6" "" "" "" "" "" "" "" "" "" "" "233.5" "224.7" "174.8" "211.0" "215.7" "220.1" "205.1" "243.2" "238.3" "236.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.001" "False" "3.651" "23" "2" "2" "2" "124" "13.7" "8.28" "5.33" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626058579617190840" "False" "High" "IsMasterProtein" "Q5VYS8" "Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1" "0.001" "False" "3.647" "1" "1" "1" "1" "1495" "171.1" "6.83" "3.46" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf03828, Pf16631, Pf19088" "79670" "ENSG00000083223" "TUT7" "hsa:79670; Q5H9T0; Q5VYS5; Q5VYS7; Q5VYS8; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811963604537530771" "False" "High" "IsMasterProtein" "Q96S15" "GATOR2 complex protein WDR24 OS=Homo sapiens OX=9606 GN=WDR24 PE=1 SV=2" "0.001" "False" "3.633" "1" "1" "1" "1" "790" "88.2" "6.52" "2.94" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "84219" "ENSG00000127580" "WDR24" "A2IDB8; D3DU59; hsa:84219; Q96GC7; Q96S15; Q9H0B7" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "High" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.001" "False" "3.626" "1" "1" "1" "1" "1040" "115.8" "6.57" "3.25" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "" "Lysosomal oligosaccharide catabolism" "1" "0" "1.108" "0.907" "0.943" "1.002" "0.940" "0.949" "1.175" "0.902" "0.966" "53.3" "59.0" "48.3" "50.2" "53.4" "50.1" "50.6" "62.6" "48.0" "51.5" "" "" "" "" "" "" "" "" "" "" "53.3" "49.9" "30.5" "36.6" "43.7" "38.9" "39.0" "53.8" "37.5" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.001" "False" "3.625" "7" "1" "2" "1" "138" "15.8" "9.60" "6.17" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.016" "1.102" "0.917" "0.992" "1.004" "1.128" "0.949" "1.065" "0.943" "242.2" "246.1" "267.0" "222.1" "240.2" "243.2" "273.1" "229.8" "258.0" "228.5" "" "" "" "" "" "" "" "" "" "" "242.2" "208.2" "168.8" "161.9" "196.8" "188.9" "210.5" "197.6" "201.3" "205.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "High" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.001" "False" "3.621" "6" "1" "1" "1" "138" "15.2" "10.29" "3.25" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3147119451307441974" "False" "High" "IsMasterProtein" "Q96MU7" "YTH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=YTHDC1 PE=1 SV=3" "0.001" "False" "3.620" "2" "2" "3" "2" "727" "84.6" "6.23" "7.42" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf04146" "91746" "ENSG00000083896; ENSG00000275272" "YTHDC1" "hsa:91746; Q4W5Q3; Q7Z622; Q8TF35; Q96MU7" "" "" "0" "0" "0.864" "2.692" "0.990" "1.088" "3.177" "0.811" "0.782" "3.108" "1.522" "26.0" "22.5" "70.1" "25.8" "28.3" "82.7" "21.1" "20.4" "80.9" "39.6" "" "" "" "" "" "" "" "" "" "" "26.0" "19.0" "44.3" "18.8" "23.2" "64.2" "16.3" "17.5" "63.1" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1893119365438926918" "False" "High" "IsMasterProtein" "Q86UU0" "B-cell CLL/lymphoma 9-like protein OS=Homo sapiens OX=9606 GN=BCL9L PE=1 SV=1" "0.001" "False" "3.619" "1" "1" "1" "1" "1499" "157.0" "8.63" "3.29" "1" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf11502" "283149" "ENSG00000186174" "BCL9L" "A1A4C1; hsa:283149; Q67FY1; Q6ZWJ0; Q6ZWK2; Q86UU0" "" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "2" "0" "0.980" "0.823" "1.059" "1.135" "0.931" "1.267" "1.174" "0.769" "0.939" "74.4" "72.8" "61.2" "78.7" "84.4" "69.3" "94.2" "87.3" "57.2" "69.8" "" "" "" "" "" "" "" "" "" "" "74.4" "61.6" "38.7" "57.4" "69.2" "53.8" "72.6" "75.1" "44.6" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.001" "False" "3.615" "2" "1" "2" "1" "524" "58.1" "5.17" "6.17" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "6" "0" "1.033" "1.166" "0.874" "0.969" "1.143" "1.241" "0.946" "1.042" "1.053" "181.6" "187.7" "211.8" "158.7" "176.0" "207.6" "225.5" "171.8" "189.3" "191.3" "" "" "" "" "" "" "" "" "" "" "181.6" "158.8" "133.9" "115.7" "144.2" "161.2" "173.8" "147.7" "147.7" "172.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7792324858940339683" "False" "High" "IsMasterProtein" "Q5THJ4" "Intermembrane lipid transfer protein VPS13D OS=Homo sapiens OX=9606 GN=VPS13D PE=1 SV=2" "0.001" "False" "3.611" "0" "1" "1" "1" "4388" "491.6" "6.58" "3.03" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes" "" "Pf00627, Pf06650, Pf12624, Pf16908, Pf16909, Pf16910" "55187" "ENSG00000048707" "VPS13D" "hsa:55187; J3KP14; Q58F10; Q5THJ4; Q6MZK9; Q6ZV12; Q709C4; Q709C5; Q86UB4; Q9NSJ3; Q9UIM0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343350754074728938" "False" "High" "IsMasterProtein" "P83881" "Large ribosomal subunit protein eL42 OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2" "0.001" "False" "3.589" "8" "1" "4" "1" "106" "12.4" "10.58" "10.28" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus" "other molecular function" "Pf00935" "6173" "ENSG00000241343" "RPL36A" "hsa:6173; P09896; P10661; P83881; Q08ES5; Q5J9I6" "Cytoplasmic ribosomal proteins" "GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.261" "1.758" "1.023" "1.220" "1.880" "1.226" "1.703" "1.899" "1.385" "100.3" "126.5" "176.4" "102.6" "122.4" "188.6" "123.0" "170.8" "190.5" "138.9" "" "" "" "" "" "" "" "" "" "" "100.3" "107.0" "111.5" "74.8" "100.3" "146.5" "94.8" "146.9" "148.7" "124.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225000128541682863" "False" "High" "IsMasterProtein" "Q99836" "Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1" "0.001" "False" "3.589" "4" "1" "1" "1" "296" "33.2" "6.15" "3.24" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf13676" "4615" "ENSG00000172936" "MYD88" "B4DKH8; B4DKU4; B4DQ60; B4DQ72; hsa:4615; J3KPU4; J3KQ87; J3KQJ6; P78397; Q53XS7; Q99836" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; HDAC6 interactions in the central nervous system; Toll-like receptor signaling pathway" "Interleukin-1 signaling; p75NTR recruits signalling complexes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ER-Phagosome pathway; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); RIP-mediated NFkB activation via ZBP1; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "35" "0" "0.960" "0.992" "1.329" "1.178" "0.993" "1.123" "1.041" "0.938" "0.965" "43.2" "41.4" "42.8" "57.4" "50.9" "42.9" "48.5" "45.0" "40.5" "41.7" "" "" "" "" "" "" "" "" "" "" "43.2" "35.1" "27.1" "41.9" "41.7" "33.3" "37.4" "38.7" "31.6" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3193827358447086587" "False" "High" "IsMasterProtein" "P20936" "Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1" "0.001" "False" "3.585" "1" "1" "1" "1" "1047" "116.3" "6.54" "3.34" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00616" "5921" "ENSG00000145715" "RASA1" "B2R6W3; B4DTL2; hsa:5921; P20936; Q68CU6; Q9UDI1" "Androgen receptor network in prostate cancer; PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; PDGFR-beta pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; GDNF signaling; EPO receptor signaling" "Regulation of RAS by GAPs; EPHB-mediated forward signaling; Downstream signal transduction; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5840239989080540215" "False" "High" "IsMasterProtein" "Q8IVH2" "Forkhead box protein P4 OS=Homo sapiens OX=9606 GN=FOXP4 PE=1 SV=1" "0.001" "False" "3.584" "2" "1" "1" "1" "680" "73.4" "6.40" "2.81" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "116113" "ENSG00000137166" "FOXP4" "hsa:116113; Q5W098; Q7Z7F8; Q8IVH2; Q8IW55; Q96E19" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "89490356486863537" "False" "High" "IsMasterProtein" "Q8TCG2" "Phosphatidylinositol 4-kinase type 2-beta OS=Homo sapiens OX=9606 GN=PI4K2B PE=1 SV=1" "0.001" "False" "3.579" "2" "1" "1" "1" "481" "54.7" "5.97" "2.91" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf00454" "55300" "ENSG00000038210" "PI4K2B" "hsa:55300; Q8TCG2; Q9NUW2" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3047103662304523242" "False" "High" "IsMasterProtein" "Q9ULD9" "Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4" "0.001" "False" "3.578" "1" "1" "1" "1" "1512" "162.1" "8.79" "1.91" "1" "other biological processes" "nucleus" "other molecular function" "" "57507" "ENSG00000168916" "ZNF608" "A7E2W9; hsa:57507; Q3SYM6; Q68D12; Q8IY05; Q9ULD9; Q9Y5A1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009616737900095404" "False" "High" "IsMasterProtein" "Q9Y2Y4" "Zinc finger and BTB domain-containing protein 32 OS=Homo sapiens OX=9606 GN=ZBTB32 PE=1 SV=1" "0.001" "False" "3.576" "2" "1" "1" "1" "487" "52.9" "9.17" "3.37" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf12874" "27033" "ENSG00000011590" "ZBTB32" "hsa:27033; Q8WVP2; Q9Y2Y4" "" "" "0" "0" "0.807" "0.774" "0.897" "1.078" "0.810" "1.091" "1.109" "0.670" "1.032" "34.2" "27.6" "26.5" "30.7" "36.9" "27.7" "37.3" "38.0" "23.0" "35.3" "" "" "" "" "" "" "" "" "" "" "34.2" "23.4" "16.8" "22.4" "30.2" "21.5" "28.8" "32.7" "17.9" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "High" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.001" "False" "3.574" "3" "2" "2" "2" "632" "71.0" "8.88" "4.46" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHOC GTPase cycle; RHOA GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle" "13" "0" "0.888" "0.992" "0.967" "1.019" "0.972" "0.939" "1.031" "0.972" "1.019" "67.7" "60.2" "67.2" "65.5" "69.0" "65.8" "63.6" "69.8" "65.8" "69.0" "" "" "" "" "" "" "" "" "" "" "67.7" "50.9" "42.5" "47.7" "56.6" "51.1" "49.0" "60.0" "51.4" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2125908269399926840" "False" "High" "IsMasterProtein" "Q9UKK3" "Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3" "0.001" "False" "3.568" "1" "1" "1" "1" "1724" "192.5" "5.66" "3.17" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00092, Pf00533, Pf00644, Pf08487" "143" "ENSG00000102699" "PARP4" "hsa:143; O75903; Q14682; Q5QNZ9; Q9H1M6; Q9UKK3" "NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-363787563517568256" "False" "High" "IsMasterProtein" "Q9H165" "B-cell lymphoma/leukemia 11A OS=Homo sapiens OX=9606 GN=BCL11A PE=1 SV=2" "0.001" "False" "3.567" "1" "1" "1" "1" "835" "91.1" "6.61" "3.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "53335" "ENSG00000119866" "BCL11A" "D6W5D7; hsa:53335; Q66LN6; Q86W14; Q8WU92; Q96JL6; Q9H163; Q9H164; Q9H165; Q9H3G9; Q9NWA7" "Prion disease pathway" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "3" "0" "1.008" "0.779" "0.934" "1.116" "0.895" "1.208" "1.220" "0.889" "0.965" "155.2" "156.5" "121.0" "145.0" "173.2" "139.0" "187.6" "189.4" "138.0" "149.8" "" "" "" "" "" "" "" "" "" "" "155.2" "132.4" "76.5" "105.8" "141.9" "107.9" "144.6" "162.9" "107.7" "134.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3524975929259860741" "False" "High" "IsMasterProtein" "Q86X27" "Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1" "0.001" "False" "3.566" "2" "1" "1" "1" "583" "65.1" "8.73" "2.81" "1" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00169, Pf00617" "55103" "ENSG00000116191" "RALGPS2" "B7Z7B1; hsa:55103; Q5T5Z1; Q5VZ67; Q86X27; Q9NW78" "" "" "0" "0" "1.145" "1.113" "1.061" "1.138" "1.052" "1.082" "1.170" "1.148" "1.148" "222.3" "254.5" "247.5" "235.9" "252.9" "233.8" "240.5" "260.0" "255.2" "255.3" "" "" "" "" "" "" "" "" "" "" "222.3" "215.3" "156.5" "172.0" "207.2" "181.6" "185.4" "223.6" "199.2" "229.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "894930863063919588" "False" "High" "IsMasterProtein" "Q86W34" "Archaemetzincin-2 OS=Homo sapiens OX=9606 GN=AMZ2 PE=1 SV=2" "0.001" "False" "3.556" "2" "1" "1" "1" "360" "41.2" "8.15" "3.47" "1" "protein metabolism" "" "other molecular function" "Pf07998" "51321" "ENSG00000196704" "AMZ2" "A6NLD9; B3KR44; hsa:51321; Q5XKF1; Q86W34; Q9NZE2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122628487347765753" "False" "High" "IsMasterProtein" "P41273" "Tumor necrosis factor ligand superfamily member 9 OS=Homo sapiens OX=9606 GN=TNFSF9 PE=1 SV=1" "0.001" "False" "3.556" "11" "2" "2" "2" "254" "26.6" "7.02" "3.19" "2" "cell-cell signaling;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf00229" "8744" "ENSG00000125657" "TNFSF9" "hsa:8744; P41273; Q2M3S2" "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling" "TNFs bind their physiological receptors" "2" "0" "1.296" "1.184" "1.244" "1.127" "1.061" "1.220" "1.228" "1.225" "1.049" "54.3" "70.4" "64.3" "67.5" "61.2" "57.6" "66.3" "66.7" "66.6" "57.0" "" "" "" "" "" "" "" "" "" "" "54.3" "59.5" "40.7" "49.2" "50.1" "44.7" "51.1" "57.4" "51.9" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494838164348438910" "False" "High" "IsMasterProtein" "Q08117" "TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4" "0.001" "False" "3.554" "5" "1" "1" "1" "197" "22.0" "6.37" "3.78" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03920" "166" "ENSG00000104964" "TLE5" "B2RBL0; hsa:166; Q08117; Q12808; Q14CJ1; Q96TG9; Q9UDY9" "Androgen receptor signaling pathway; Ectoderm differentiation" "Repression of WNT target genes" "3" "0" "1.020" "0.858" "1.098" "1.122" "0.979" "1.086" "1.031" "0.922" "1.060" "137.4" "140.2" "117.9" "150.9" "154.2" "134.5" "149.2" "141.7" "126.7" "145.6" "" "" "" "" "" "" "" "" "" "" "137.4" "118.6" "74.6" "110.0" "126.4" "104.4" "115.0" "121.9" "98.9" "130.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.001" "False" "3.550" "21" "2" "3" "2" "77" "8.5" "8.75" "8.17" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.835" "1.082" "0.867" "0.878" "0.998" "1.029" "0.869" "1.004" "0.920" "353.5" "295.1" "382.7" "306.6" "310.3" "352.7" "363.9" "307.2" "355.0" "325.1" "" "" "" "" "" "" "" "" "" "" "353.5" "249.6" "242.0" "223.6" "254.2" "273.9" "280.5" "264.2" "277.1" "292.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1668082602578177329" "False" "High" "IsMasterProtein" "O95625" "Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2" "0.001" "False" "3.539" "1" "1" "2" "1" "1053" "119.3" "8.66" "4.92" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912, Pf17921" "27107" "ENSG00000066422" "ZBTB11" "hsa:27107; O95625; Q2NKP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6192952789392002261" "False" "High" "IsMasterProtein" "O15085" "Rho guanine nucleotide exchange factor 11 OS=Homo sapiens OX=9606 GN=ARHGEF11 PE=1 SV=1" "0.001" "False" "3.538" "1" "1" "1" "1" "1522" "167.6" "5.50" "3.76" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00595, Pf00621, Pf09128, Pf17838" "9826" "ENSG00000132694" "ARHGEF11" "D3DVD0; hsa:9826; O15085; Q5VY40; Q6PFW2" "" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse" "8" "0" "0.985" "1.084" "1.088" "1.081" "1.163" "1.161" "1.082" "0.948" "1.260" "61.0" "60.0" "66.1" "66.3" "65.9" "70.9" "70.8" "66.0" "57.8" "76.8" "" "" "" "" "" "" "" "" "" "" "61.0" "50.8" "41.8" "48.4" "54.0" "55.1" "54.6" "56.7" "45.1" "69.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5887664116474982474" "False" "High" "IsMasterProtein" "Q9H6E4" "Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1" "0.001" "False" "3.533" "5" "1" "2" "1" "229" "26.5" "8.85" "4.60" "1" "developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf15002" "79879" "ENSG00000100147" "CCDC134" "hsa:79879; Q9H6E4" "" "" "0" "0" "1.337" "0.730" "0.997" "0.995" "1.080" "1.166" "1.268" "0.960" "1.094" "25.9" "34.6" "18.9" "25.8" "25.7" "27.9" "30.2" "32.8" "24.8" "28.3" "" "" "" "" "" "" "" "" "" "" "25.9" "29.3" "11.9" "18.8" "21.1" "21.7" "23.3" "28.2" "19.4" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.001" "False" "3.533" "2" "1" "1" "1" "457" "49.8" "8.41" "3.32" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "RET signaling" "4" "0" "1.137" "0.932" "1.144" "1.048" "0.992" "1.113" "1.042" "0.909" "1.006" "162.6" "184.8" "151.5" "185.9" "170.4" "161.3" "180.9" "169.4" "147.7" "163.6" "" "" "" "" "" "" "" "" "" "" "162.6" "156.3" "95.8" "135.6" "139.6" "125.2" "139.4" "145.6" "115.3" "147.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.001" "False" "3.529" "3" "1" "1" "1" "349" "38.2" "5.50" "2.13" "1" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "" "The role of GTSE1 in G2/M progression after G2 checkpoint" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2370626703481031957" "False" "High" "IsMasterProtein" "Q9H7N4" "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" "0.001" "False" "3.528" "1" "1" "1" "1" "1312" "139.2" "9.25" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "58506" "ENSG00000126461" "SCAF1" "hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.001" "False" "3.527" "5" "1" "1" "1" "148" "16.9" "5.39" "3.72" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "Myometrial relaxation and contraction pathways" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032311727132364318" "False" "High" "IsMasterProtein" "Q8IVV7" "Glucose-induced degradation protein 4 homolog OS=Homo sapiens OX=9606 GN=GID4 PE=1 SV=1" "0.001" "False" "3.518" "3" "1" "1" "1" "300" "33.5" "9.16" "3.16" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf09783" "79018" "ENSG00000141034" "GID4" "hsa:79018; Q8IVV7; Q8TEB5; Q9BW50" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.014" "0.885" "1.057" "1.046" "0.907" "1.251" "0.956" "1.010" "1.015" "92.3" "93.6" "81.7" "97.5" "96.6" "83.7" "115.4" "88.3" "93.3" "93.7" "" "" "" "" "" "" "" "" "" "" "92.3" "79.2" "51.6" "71.1" "79.1" "65.0" "89.0" "75.9" "72.8" "84.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3887179328578035438" "False" "High" "IsMasterProtein" "P0C7X2" "Zinc finger protein 688 OS=Homo sapiens OX=9606 GN=ZNF688 PE=1 SV=1" "0.001" "False" "3.514" "3" "1" "1" "1" "276" "30.6" "9.25" "3.37" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "146542" "ENSG00000229809" "ZNF688" "A8MV39; B3KV51; hsa:146542; O75701; P0C7X2; Q8IW91; Q8WV14; Q96MN0" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.001" "False" "3.513" "5" "1" "1" "1" "152" "17.0" "8.95" "3.22" "1" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "0.873" "1.059" "0.742" "0.965" "1.134" "1.052" "0.867" "1.075" "0.886" "96.9" "84.7" "102.7" "71.9" "93.5" "109.9" "101.9" "84.1" "104.2" "85.9" "" "" "" "" "" "" "" "" "" "" "96.9" "71.6" "64.9" "52.4" "76.6" "85.4" "78.6" "72.3" "81.3" "77.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887438287931190959" "False" "High" "IsMasterProtein" "Q8IZX4" "Transcription initiation factor TFIID subunit 1-like OS=Homo sapiens OX=9606 GN=TAF1L PE=1 SV=1" "0.001" "False" "3.494" "1" "1" "1" "1" "1826" "207.2" "5.40" "3.40" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf09247, Pf12157, Pf15288" "138474" "ENSG00000122728" "TAF1L" "hsa:138474; Q0VG57; Q8IZX4" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "1.038" "0.903" "1.227" "1.201" "1.028" "1.270" "1.097" "0.978" "1.003" "117.5" "122.0" "106.1" "144.2" "141.1" "120.8" "149.3" "128.9" "114.9" "117.9" "" "" "" "" "" "" "" "" "" "" "117.5" "103.2" "67.1" "105.1" "115.6" "93.8" "115.1" "110.8" "89.7" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.001" "False" "3.490" "2" "1" "1" "1" "464" "50.8" "8.21" "2.45" "1" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "Not Found" "1" "" "-4254147789153280630" "False" "High" "IsMasterProtein" "Q9BZ68" "Putative FERM domain-containing protein FRMD8P1 OS=Homo sapiens OX=9606 GN=FRMD8P1 PE=5 SV=2" "0.001" "False" "3.482" "2" "1" "1" "1" "369" "41.1" "5.82" "3.45" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373" "" "" "FRMD8P1" "A1A4X4; Q9BZ68" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-582593904784736124" "False" "High" "IsMasterProtein" "Q9Y5W9" "Sorting nexin-11 OS=Homo sapiens OX=9606 GN=SNX11 PE=1 SV=2" "0.001" "False" "3.468" "4" "1" "1" "1" "270" "30.4" "7.05" "1.90" "1" "cell organization and biogenesis;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29916" "ENSG00000002919" "SNX11" "B3KRL6; B4DPY5; D3DTV0; hsa:29916; Q53YC0; Q9H885; Q9Y5W9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4689562730932566719" "False" "High" "IsMasterProtein" "Q9Y620" "DNA repair and recombination protein RAD54B OS=Homo sapiens OX=9606 GN=RAD54B PE=1 SV=1" "0.001" "False" "3.465" "1" "1" "1" "1" "910" "102.9" "8.12" "2.30" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "25788" "ENSG00000197275" "RAD54B" "F6WBS8; hsa:25788; Q9Y620" "Homologous recombination; DNA repair pathways, full network" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.001" "False" "3.461" "2" "1" "1" "1" "467" "53.9" "6.33" "3.27" "1" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "1.007" "0.865" "1.205" "1.374" "1.060" "1.395" "1.271" "1.098" "0.856" "50.0" "50.3" "43.2" "60.2" "68.7" "52.9" "69.7" "63.5" "54.9" "42.8" "" "" "" "" "" "" "" "" "" "" "50.0" "42.6" "27.3" "43.9" "56.3" "41.1" "53.7" "54.6" "42.8" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-511612548329445483" "False" "High" "IsMasterProtein" "P32970" "CD70 antigen OS=Homo sapiens OX=9606 GN=CD70 PE=1 SV=2" "0.001" "False" "3.459" "6" "1" "1" "1" "193" "21.1" "8.53" "3.87" "1" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf00229" "970" "ENSG00000125726" "CD70" "B4DPR8; hsa:970; P32970; Q53XX4; Q96J57" "" "TNFs bind their physiological receptors" "1" "0" "0.994" "0.892" "1.151" "1.123" "1.000" "1.054" "1.121" "0.910" "1.131" "93.2" "92.7" "83.2" "107.3" "104.7" "93.2" "98.3" "104.5" "84.9" "105.4" "" "" "" "" "" "" "" "" "" "" "93.2" "78.4" "52.6" "78.2" "85.8" "72.4" "75.8" "89.9" "66.2" "94.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286717889543307804" "False" "High" "IsMasterProtein" "O94889" "Kelch-like protein 18 OS=Homo sapiens OX=9606 GN=KLHL18 PE=1 SV=3" "0.001" "False" "3.457" "3" "1" "1" "1" "574" "63.6" "5.60" "3.28" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "23276" "ENSG00000114648" "KLHL18" "A8K612; hsa:23276; O94889; Q7Z3E8; Q8N125" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9165007621832030545" "False" "High" "IsMasterProtein" "Q7Z624" "Calmodulin-lysine N-methyltransferase OS=Homo sapiens OX=9606 GN=CAMKMT PE=1 SV=2" "0.001" "False" "3.448" "4" "1" "1" "1" "323" "36.1" "6.83" "3.35" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf10294" "79823" "ENSG00000143919" "CAMKMT" "hsa:79823; Q4ZG15; Q53SS6; Q7Z624; Q8N6P5; Q9H5G8" "" "Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation" "2" "0" "1.245" "1.147" "1.067" "1.208" "1.159" "1.246" "1.241" "1.200" "1.094" "86.7" "108.0" "99.4" "92.5" "104.8" "100.5" "108.1" "107.6" "104.0" "94.9" "" "" "" "" "" "" "" "" "" "" "86.7" "91.4" "62.9" "67.5" "85.9" "78.1" "83.3" "92.5" "81.2" "85.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4165561941768478758" "False" "High" "IsMasterProtein" "Q9UID6" "Zinc finger protein 639 OS=Homo sapiens OX=9606 GN=ZNF639 PE=1 SV=1" "0.001" "False" "3.447" "2" "1" "1" "1" "485" "56.0" "5.57" "3.54" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "51193" "ENSG00000121864" "ZNF639" "A9X3Z9; D3DNR3; hsa:51193; Q9UID6" "" "" "0" "0" "0.942" "0.725" "1.057" "0.984" "0.834" "1.065" "1.178" "0.755" "0.929" "95.3" "89.8" "69.1" "100.7" "93.8" "79.5" "101.5" "112.3" "71.9" "88.6" "" "" "" "" "" "" "" "" "" "" "95.3" "76.0" "43.7" "73.5" "76.8" "61.7" "78.3" "96.5" "56.1" "79.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "High" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.001" "False" "3.446" "1" "1" "1" "1" "758" "84.4" "9.76" "3.13" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "1.124" "0.723" "1.168" "1.124" "1.009" "1.306" "1.291" "0.965" "1.111" "65.8" "73.9" "47.6" "76.8" "73.9" "66.4" "85.9" "84.9" "63.5" "73.1" "" "" "" "" "" "" "" "" "" "" "65.8" "62.6" "30.1" "56.0" "60.6" "51.5" "66.2" "73.0" "49.6" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "High" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.001" "False" "3.442" "16" "2" "3" "2" "97" "11.1" "11.74" "7.54" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "1.081" "1.403" "0.952" "1.040" "1.345" "1.078" "1.192" "1.620" "1.048" "219.6" "237.3" "308.2" "209.2" "228.5" "295.4" "236.7" "261.8" "355.7" "230.0" "" "" "" "" "" "" "" "" "" "" "219.6" "200.8" "194.9" "152.5" "187.2" "229.4" "182.4" "225.1" "277.6" "206.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469861955524626528" "False" "High" "IsMasterProtein" "Q9BTX7" "Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2" "0.001" "False" "3.439" "8" "2" "2" "2" "342" "38.5" "6.44" "3.46" "2" "" "" "other molecular function" "Pf00650, Pf03765" "79183" "ENSG00000124120" "TTPAL" "E1P5X3; hsa:79183; Q5QPC1; Q9BTX7; Q9H1G2; Q9NQG8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8771198256922364078" "False" "High" "IsMasterProtein" "P10244" "Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1" "0.001" "False" "3.439" "1" "1" "1" "1" "700" "78.7" "6.87" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf09316, Pf13921" "4605" "ENSG00000101057" "MYBL2" "B2RBS5; B7Z8D9; F8W6N6; hsa:4605; P10244; Q53F07" "Gastric cancer network 1; EGF/EGFR signaling pathway" "Polo-like kinase mediated events; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.001" "False" "3.438" "4" "1" "1" "1" "268" "29.3" "8.91" "3.91" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "High" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.001" "False" "3.435" "7" "2" "2" "2" "382" "43.1" "8.07" "4.75" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "" "XBP1(S) activates chaperone genes" "1" "0" "1.156" "1.047" "0.958" "1.204" "1.303" "1.333" "1.131" "1.168" "1.048" "52.3" "60.5" "54.8" "50.1" "63.0" "68.2" "69.8" "59.1" "61.1" "54.9" "" "" "" "" "" "" "" "" "" "" "52.3" "51.2" "34.6" "36.6" "51.6" "52.9" "53.8" "50.9" "47.7" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1947513766824077482" "False" "High" "IsMasterProtein" "Q9HCU9" "Breast cancer metastasis-suppressor 1 OS=Homo sapiens OX=9606 GN=BRMS1 PE=1 SV=1" "0.001" "False" "3.435" "5" "1" "1" "1" "246" "28.4" "4.74" "3.17" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf08598" "25855" "ENSG00000174744" "BRMS1" "hsa:25855; Q6IAI2; Q9HCU9" "" "Potential therapeutics for SARS; HDACs deacetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774592991242960215" "False" "High" "IsMasterProtein" "Q9H0H0" "Integrator complex subunit 2 OS=Homo sapiens OX=9606 GN=INTS2 PE=1 SV=2" "0.001" "False" "3.422" "1" "1" "1" "1" "1204" "134.2" "6.05" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf14750" "57508" "ENSG00000108506" "INTS2" "hsa:57508; Q9H0H0; Q9ULD3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.001" "False" "3.414" "3" "1" "1" "1" "300" "32.5" "6.28" "3.67" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "1.022" "1.033" "1.084" "1.243" "0.889" "1.344" "1.200" "0.911" "1.086" "137.6" "140.6" "142.1" "149.1" "171.0" "122.4" "185.0" "165.1" "125.4" "149.4" "" "" "" "" "" "" "" "" "" "" "137.6" "119.0" "89.8" "108.7" "140.1" "95.0" "142.6" "141.9" "97.9" "134.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1490025525500914879" "False" "High" "IsMasterProtein" "O43929" "Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2" "0.001" "False" "3.407" "3" "1" "1" "1" "436" "50.3" "8.00" "2.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14629" "5000" "ENSG00000115947" "ORC4" "B7Z3D0; B7Z5F1; D3DP86; F5H069; hsa:5000; O43929; Q96C42" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "1.180" "1.057" "0.859" "1.145" "1.038" "0.997" "1.031" "0.856" "0.922" "47.6" "56.2" "50.4" "40.9" "54.5" "49.4" "47.5" "49.1" "40.8" "43.9" "" "" "" "" "" "" "" "" "" "" "47.6" "47.6" "31.8" "29.8" "44.7" "38.4" "36.6" "42.2" "31.8" "39.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1965272560754222552" "False" "High" "IsMasterProtein" "Q9BZ29" "Dedicator of cytokinesis protein 9 OS=Homo sapiens OX=9606 GN=DOCK9 PE=1 SV=2" "0.001" "False" "3.405" "0" "1" "1" "1" "2069" "236.3" "7.49" "2.72" "1" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "23348" "ENSG00000088387" "DOCK9" "B3KX25; E9PFM9; hsa:23348; Q5JUD4; Q5JUD6; Q5T2Q1; Q5TAN8; Q9BZ25; Q9BZ26; Q9BZ27; Q9BZ28; Q9BZ29; Q9UPU4" "" "RAC1 GTPase cycle; CDC42 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7862445690525938863" "False" "High" "IsMasterProtein" "P32455" "Guanylate-binding protein 1 OS=Homo sapiens OX=9606 GN=GBP1 PE=1 SV=2" "0.001" "False" "3.404" "3" "2" "2" "2" "592" "67.9" "6.32" "4.78" "2" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02263, Pf02841" "2633" "ENSG00000117228" "GBP1" "D3DT26; hsa:2633; P32455; Q5T8M1" "Type II interferon signaling" "Interferon gamma signaling" "2" "0" "1.132" "1.141" "1.305" "1.275" "1.231" "1.235" "1.122" "1.181" "1.169" "60.8" "68.8" "69.3" "79.3" "77.5" "74.8" "75.0" "68.2" "71.7" "71.0" "" "" "" "" "" "" "" "" "" "" "60.8" "58.2" "43.8" "57.8" "63.5" "58.1" "57.8" "58.6" "56.0" "63.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355832090730620748" "False" "High" "IsMasterProtein" "Q03169" "Tumor necrosis factor alpha-induced protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP2 PE=1 SV=2" "0.001" "False" "3.401" "3" "2" "3" "2" "654" "72.6" "6.46" "7.70" "2" "transport;developmental processes;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf06046" "7127" "ENSG00000185215" "TNFAIP2" "hsa:7127; Q03169; Q86VI0" "IL-18 signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8678565654600364554" "False" "High" "IsMasterProtein" "Q8WWV3" "Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2" "0.001" "False" "3.395" "2" "1" "1" "1" "396" "43.6" "9.11" "3.28" "1" "developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf08240, Pf13602" "84816" "ENSG00000130347" "RTN4IP1" "hsa:84816; Q8N9B3; Q8WWV3; Q8WZ66; Q9BRA4" "" "" "0" "0" "0.965" "0.852" "1.018" "0.986" "0.873" "1.080" "0.960" "0.901" "0.962" "127.2" "122.7" "108.3" "129.4" "125.4" "111.1" "137.3" "122.1" "114.6" "122.3" "" "" "" "" "" "" "" "" "" "" "127.2" "103.8" "68.5" "94.3" "102.7" "86.2" "105.8" "105.0" "89.5" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4759143822293773725" "False" "High" "IsMasterProtein" "Q9Y366" "Intraflagellar transport protein 52 homolog OS=Homo sapiens OX=9606 GN=IFT52 PE=1 SV=3" "0.001" "False" "3.392" "3" "1" "1" "1" "437" "49.7" "5.26" "2.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf09822, Pf21178" "51098" "ENSG00000101052" "IFT52" "B3KMA1; E1P5W9; hsa:51098; Q5H8Z0; Q9H1G3; Q9H1G4; Q9H1H2; Q9Y366" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "Intraflagellar transport; Hedgehog 'off' state" "6" "0" "1.053" "0.910" "1.212" "1.245" "1.272" "1.314" "1.199" "1.128" "1.132" "20.5" "21.6" "18.7" "24.9" "25.6" "26.1" "27.0" "24.6" "23.2" "23.3" "" "" "" "" "" "" "" "" "" "" "20.5" "18.3" "11.8" "18.2" "21.0" "20.3" "20.8" "21.2" "18.1" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4302556008406665398" "False" "High" "IsMasterProtein" "P20591" "Interferon-induced GTP-binding protein Mx1 OS=Homo sapiens OX=9606 GN=MX1 PE=1 SV=4" "0.001" "False" "3.385" "2" "1" "1" "1" "662" "75.5" "5.83" "2.75" "1" "stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "4599" "ENSG00000157601" "MX1" "B2RDA5; B3KU10; C9IYV7; C9J8D6; C9JN19; C9JN88; C9JUL1; C9JZS6; D3DSI8; hsa:4599; P20591; Q86YP5; Q96CI3" "Immune response to tuberculosis; Measles virus infection; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "ISG15 antiviral mechanism; Interferon alpha/beta signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.001" "False" "3.384" "6" "2" "2" "2" "325" "35.7" "4.74" "4.06" "2" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5570011762610831178" "False" "High" "IsMasterProtein" "Q99685" "Monoglyceride lipase OS=Homo sapiens OX=9606 GN=MGLL PE=1 SV=2" "0.001" "False" "3.382" "3" "1" "1" "1" "303" "33.2" "6.99" "3.45" "1" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf12146" "11343" "ENSG00000074416" "MGLL" "B3KRC2; B7Z9D1; hsa:11343; Q6IBG9; Q96AA5; Q99685" "Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; Familial partial lipodystrophy" "Triglyceride catabolism; Acyl chain remodeling of DAG and TAG; Arachidonate production from DAG" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1804572452754127455" "False" "High" "IsMasterProtein" "Q96AW1" "WW domain binding protein VOPP1 OS=Homo sapiens OX=9606 GN=VOPP1 PE=1 SV=1" "0.001" "False" "3.380" "5" "1" "1" "1" "172" "19.2" "8.40" "3.01" "1" "" "other membranes;other cytoplasmic organelle" "other molecular function" "" "81552" "ENSG00000154978" "VOPP1" "B0AZU1; B2RAT4; B3KS72; C9JWR3; hsa:81552; Q6FIE3; Q8NBN8; Q96AW1; Q96RE5; Q9H0W4" "" "" "0" "0" "1.075" "1.141" "1.108" "1.208" "1.357" "1.088" "1.193" "1.015" "1.141" "42.3" "45.5" "48.3" "46.9" "51.1" "57.4" "46.1" "50.5" "43.0" "48.3" "" "" "" "" "" "" "" "" "" "" "42.3" "38.5" "30.5" "34.2" "41.9" "44.6" "35.5" "43.4" "33.5" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "78901819500717128" "False" "High" "IsMasterProtein" "Q96AH0" "SOSS complex subunit B2 OS=Homo sapiens OX=9606 GN=NABP1 PE=1 SV=1" "0.001" "False" "3.379" "4" "1" "1" "1" "204" "22.4" "9.58" "3.65" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf21473" "64859" "ENSG00000173559" "NABP1" "hsa:64859; Q658Y8; Q96AH0; Q9H5X6" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.074" "0.680" "1.116" "0.973" "0.689" "1.111" "1.136" "0.806" "1.013" "74.6" "80.1" "50.8" "83.3" "72.6" "51.4" "82.9" "84.8" "60.1" "75.6" "" "" "" "" "" "" "" "" "" "" "74.6" "67.8" "32.1" "60.7" "59.5" "39.9" "63.9" "72.9" "46.9" "68.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "186297121193818465" "False" "High" "IsMasterProtein" "Q5QJ74" "Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens OX=9606 GN=TBCEL PE=1 SV=2" "0.001" "False" "3.377" "3" "1" "2" "1" "424" "48.2" "5.38" "2.15" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf14560, Pf14580" "219899" "ENSG00000154114" "TBCEL" "hsa:219899; Q0VAN6; Q5QJ74" "" "" "0" "0" "1.296" "0.820" "1.049" "1.537" "1.399" "1.108" "1.090" "1.003" "1.069" "27.9" "36.2" "22.9" "29.3" "42.9" "39.0" "30.9" "30.4" "28.0" "29.8" "" "" "" "" "" "" "" "" "" "" "27.9" "30.6" "14.5" "21.3" "35.2" "30.3" "23.8" "26.2" "21.9" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7619751379045493323" "False" "High" "IsMasterProtein" "P04062" "Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3" "0.001" "False" "3.363" "2" "1" "1" "1" "536" "59.7" "7.61" "2.92" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf02055, Pf17189" "2629" "ENSG00000177628" "GBA1" "A8K796; B7Z5G2; B7Z6S1; hsa:2629; J3KQG4; J3KQK9; P04062; Q16545; Q4VX22; Q6I9R6; Q9UMJ8" "Sphingolipid pathway" "Association of TriC/CCT with target proteins during biosynthesis; Glycosphingolipid catabolism" "3" "0" "1.025" "0.862" "1.042" "1.054" "1.117" "1.080" "1.008" "0.845" "1.053" "72.3" "74.1" "62.3" "75.3" "76.2" "80.7" "78.0" "72.8" "61.0" "76.1" "" "" "" "" "" "" "" "" "" "" "72.3" "62.7" "39.4" "54.9" "62.4" "62.7" "60.2" "62.6" "47.7" "68.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.001" "False" "3.360" "3" "2" "2" "2" "531" "59.7" "5.40" "2.86" "2" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "IL-18 signaling pathway" "" "1" "0" "0.993" "1.028" "1.053" "1.237" "1.249" "1.223" "1.163" "1.087" "1.051" "64.9" "64.5" "66.7" "68.3" "80.3" "81.1" "79.4" "75.5" "70.6" "68.2" "" "" "" "" "" "" "" "" "" "" "64.9" "54.5" "42.2" "49.8" "65.8" "62.9" "61.2" "64.9" "55.1" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7932512641698154547" "False" "High" "IsMasterProtein" "Q9UH92" "Max-like protein X OS=Homo sapiens OX=9606 GN=MLX PE=1 SV=2" "0.001" "False" "3.360" "3" "1" "1" "1" "298" "33.3" "8.06" "3.16" "1" "other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6945" "ENSG00000108788" "MLX" "A8K2J3; B2RAV8; B2RD73; hsa:6945; Q53XM6; Q96FL2; Q9H2V0; Q9H2V1; Q9H2V2; Q9NXN3; Q9UH92" "Nonalcoholic fatty liver disease" "ChREBP activates metabolic gene expression" "2" "0" "0.907" "0.732" "1.165" "0.953" "0.931" "1.108" "1.097" "0.999" "0.963" "52.6" "47.7" "38.5" "61.2" "50.1" "48.9" "58.2" "57.6" "52.5" "50.6" "" "" "" "" "" "" "" "" "" "" "52.6" "40.3" "24.3" "44.6" "41.0" "38.0" "44.9" "49.6" "41.0" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1457147367295860872" "False" "High" "IsMasterProtein" "Q9BXL8" "Cell division cycle-associated protein 4 OS=Homo sapiens OX=9606 GN=CDCA4 PE=1 SV=1" "0.001" "False" "3.358" "4" "1" "1" "1" "241" "26.1" "4.97" "3.08" "1" "" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf06031" "55038" "ENSG00000170779" "CDCA4" "hsa:55038; Q8TB18; Q9BXL8; Q9NWK7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5546431663136658050" "False" "High" "IsMasterProtein" "Q9UK39" "Nocturnin OS=Homo sapiens OX=9606 GN=NOCT PE=1 SV=2" "0.001" "False" "3.356" "3" "1" "2" "1" "431" "48.2" "7.23" "4.51" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "25819" "ENSG00000151014" "NOCT" "D3DNY5; hsa:25819; Q14D51; Q9HD93; Q9HD94; Q9HD95; Q9UK39" "Orexin receptor pathway" "BMAL1:CLOCK,NPAS2 activates circadian gene expression" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1437377503696460912" "False" "High" "IsMasterProtein" "Q6Q0C0" "E3 ubiquitin-protein ligase TRAF7 OS=Homo sapiens OX=9606 GN=TRAF7 PE=1 SV=1" "0.001" "False" "3.354" "3" "2" "2" "2" "670" "74.6" "7.15" "5.39" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00400, Pf13445" "84231" "ENSG00000131653" "TRAF7" "hsa:84231; Q6Q0C0; Q9H073" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.969" "0.802" "1.039" "0.995" "0.854" "1.075" "1.057" "0.884" "0.992" "155.2" "150.4" "124.5" "161.3" "154.4" "132.6" "166.8" "164.0" "137.1" "153.9" "" "" "" "" "" "" "" "" "" "" "155.2" "127.2" "78.7" "117.6" "126.5" "103.0" "128.5" "141.0" "107.0" "138.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1043542800326556912" "False" "High" "IsMasterProtein" "Q9NRA0" "Sphingosine kinase 2 OS=Homo sapiens OX=9606 GN=SPHK2 PE=1 SV=2" "0.001" "False" "3.353" "2" "1" "1" "1" "654" "69.2" "6.95" "2.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00781, Pf19279" "56848" "ENSG00000063176" "SPHK2" "A0T4C8; B4DU87; hsa:56848; Q9BRN1; Q9H0Q2; Q9NRA0; Q9NWU7" "Sphingolipid pathway; S1P receptor signal transduction; Metabolism of sphingolipids in ER and Golgi apparatus; Sphingolipid metabolism: integrated pathway; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids" "Sphingolipid de novo biosynthesis" "7" "0" "0.870" "0.839" "0.820" "1.082" "0.770" "0.930" "0.855" "0.790" "0.976" "43.7" "38.1" "36.7" "35.8" "47.3" "33.7" "40.7" "37.4" "34.5" "42.7" "" "" "" "" "" "" "" "" "" "" "43.7" "32.2" "23.2" "26.1" "38.8" "26.1" "31.4" "32.1" "27.0" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.001" "False" "3.344" "6" "1" "1" "1" "247" "26.9" "6.37" "2.71" "1" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "1.081" "0.932" "1.060" "1.053" "1.142" "0.946" "0.839" "1.017" "0.981" "32.4" "35.1" "30.2" "34.4" "34.2" "37.1" "30.7" "27.2" "33.0" "31.8" "" "" "" "" "" "" "" "" "" "" "32.4" "29.7" "19.1" "25.1" "28.0" "28.8" "23.7" "23.4" "25.8" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.001" "False" "3.344" "3" "1" "1" "1" "323" "35.5" "6.23" "3.74" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "1.214" "1.074" "1.165" "1.019" "1.123" "1.205" "0.990" "1.158" "1.092" "60.0" "72.9" "64.5" "69.9" "61.2" "67.4" "72.4" "59.4" "69.5" "65.5" "" "" "" "" "" "" "" "" "" "" "60.0" "61.7" "40.8" "51.0" "50.1" "52.4" "55.8" "51.1" "54.3" "58.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3542349619496752208" "False" "High" "IsMasterProtein" "Q96CN4" "EVI5-like protein OS=Homo sapiens OX=9606 GN=EVI5L PE=1 SV=1" "0.001" "False" "3.343" "2" "2" "2" "2" "794" "91.3" "5.34" "3.70" "2" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf00566" "115704" "ENSG00000142459" "EVI5L" "B9A6I9; hsa:115704; Q96CN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802259196988862678" "False" "High" "IsMasterProtein" "Q9NUY8" "TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3" "0.001" "False" "3.342" "2" "1" "1" "1" "699" "78.3" "5.41" "3.19" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cell component" "" "Pf00566, Pf00581, Pf19430" "55773" "ENSG00000036054" "TBC1D23" "B9A6M5; hsa:55773; Q8TCN8; Q8WUB7; Q96D90; Q9NUY8; Q9NV75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969032140850025003" "False" "High" "IsMasterProtein" "O60674" "Tyrosine-protein kinase JAK2 OS=Homo sapiens OX=9606 GN=JAK2 PE=1 SV=2" "0.001" "False" "3.341" "1" "2" "2" "1" "1132" "130.6" "7.21" "4.98" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714, Pf17887, Pf18377, Pf18379" "3717" "ENSG00000096968" "JAK2" "hsa:3717; O14636; O60674; O75297" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; Th17 cell differentiation pathway; Clock-controlled autophagy in bone metabolism; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling; Serotonin HTR1 group and FOS pathway" "Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs" "80" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.001" "False" "3.329" "6" "1" "1" "1" "167" "18.8" "5.12" "3.77" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "1.078" "1.018" "1.140" "1.219" "0.921" "1.235" "1.084" "0.857" "1.306" "73.9" "79.7" "75.2" "84.2" "90.1" "68.0" "91.3" "80.1" "63.3" "96.6" "" "" "" "" "" "" "" "" "" "" "73.9" "67.4" "47.6" "61.4" "73.8" "52.8" "70.4" "68.9" "49.4" "86.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.001" "False" "3.322" "4" "1" "1" "1" "183" "20.6" "4.67" "3.73" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Ciliary landscape" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.992" "1.102" "1.065" "0.933" "1.022" "0.989" "1.000" "1.008" "0.980" "154.9" "153.6" "170.7" "164.9" "144.5" "158.2" "153.2" "154.8" "156.1" "151.8" "" "" "" "" "" "" "" "" "" "" "154.9" "130.0" "107.9" "120.3" "118.4" "122.9" "118.1" "133.1" "121.9" "136.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850539477477938049" "False" "High" "IsMasterProtein" "Q9Y2J8" "Protein-arginine deiminase type-2 OS=Homo sapiens OX=9606 GN=PADI2 PE=1 SV=2" "0.001" "False" "3.316" "2" "1" "2" "1" "665" "75.5" "5.59" "6.11" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03068, Pf08526, Pf08527" "11240" "ENSG00000117115; ENSG00000291387" "PADI2" "hsa:11240; Q96DA7; Q9UPN2; Q9Y2J8" "" "Neutrophil degranulation; Chromatin modifying enzymes" "2" "0" "1.299" "1.181" "1.082" "1.139" "1.395" "1.250" "1.293" "1.181" "1.199" "31.5" "41.0" "37.2" "34.1" "35.9" "44.0" "39.4" "40.8" "37.2" "37.8" "" "" "" "" "" "" "" "" "" "" "31.5" "34.7" "23.5" "24.9" "29.4" "34.1" "30.4" "35.1" "29.1" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7542471958177645128" "False" "High" "IsMasterProtein" "Q8TBC3" "SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2" "0.001" "False" "3.315" "1" "1" "1" "1" "707" "76.3" "8.28" "3.12" "1" "cell organization and biogenesis;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf02214" "92799" "ENSG00000160410" "SHKBP1" "Q8N2I6; Q8TBC3; Q8WY93; Q96IB8" "" "CDC42 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.001" "False" "3.315" "1" "1" "1" "1" "1267" "139.4" "5.76" "2.88" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "1.111" "0.868" "1.128" "1.230" "1.187" "1.241" "1.172" "0.883" "1.203" "39.9" "44.3" "34.6" "45.0" "49.1" "47.4" "49.5" "46.8" "35.2" "48.0" "" "" "" "" "" "" "" "" "" "" "39.9" "37.5" "21.9" "32.8" "40.2" "36.8" "38.2" "40.2" "27.5" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6351982484354438023" "False" "High" "IsMasterProtein" "Q96E14" "RecQ-mediated genome instability protein 2 OS=Homo sapiens OX=9606 GN=RMI2 PE=1 SV=2" "0.001" "False" "3.311" "12" "2" "2" "2" "147" "15.9" "7.90" "5.35" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf16100" "116028" "ENSG00000175643" "RMI2" "B3KVZ6; hsa:116028; Q49AE2; Q8TBL0; Q96E14" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "1.062" "0.914" "1.025" "1.181" "0.950" "1.200" "1.115" "0.954" "1.030" "149.1" "158.3" "136.3" "152.9" "176.0" "141.6" "178.9" "166.3" "142.3" "153.6" "" "" "" "" "" "" "" "" "" "" "149.1" "133.9" "86.2" "111.5" "144.2" "110.0" "137.9" "143.0" "111.1" "138.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534484608378348231" "False" "High" "IsMasterProtein" "Q9H000" "E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2" "0.001" "False" "3.310" "2" "1" "1" "1" "416" "46.9" "7.61" "3.62" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00097, Pf00642, Pf14608" "23609" "ENSG00000075975" "MKRN2" "A6NIA2; B3KRC5; B4DPR4; Q8N391; Q96BD4; Q9BUY2; Q9H000; Q9NRY1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337623474681162042" "False" "High" "IsMasterProtein" "P18074" "General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1" "0.001" "False" "3.310" "1" "1" "1" "1" "760" "86.9" "7.15" "2.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf06777, Pf13307" "2068" "ENSG00000104884" "ERCC2" "hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721" "Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.001" "False" "3.307" "3" "1" "1" "1" "327" "36.5" "5.41" "2.53" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.096" "1.010" "1.061" "1.041" "1.156" "1.142" "0.979" "1.040" "0.902" "69.6" "76.3" "70.3" "73.8" "72.5" "80.5" "79.5" "68.2" "72.4" "62.8" "" "" "" "" "" "" "" "" "" "" "69.6" "64.6" "44.5" "53.8" "59.4" "62.5" "61.3" "58.6" "56.5" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960186512465263261" "False" "High" "IsMasterProtein" "Q96L93" "Kinesin-like protein KIF16B OS=Homo sapiens OX=9606 GN=KIF16B PE=1 SV=2" "0.001" "False" "3.299" "1" "1" "1" "1" "1317" "151.9" "6.16" "3.57" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf00787" "55614" "ENSG00000089177" "KIF16B" "A6NKJ9; A7E2A8; B1AKG3; B1AKT7; C9JDN5; C9JI52; C9JSM8; C9JWJ7; hsa:55614; Q2TBF5; Q5HYC0; Q5HYK1; Q5JWW3; Q5TFK5; Q86VL9; Q86YS5; Q8IYU0; Q96L93; Q9BQJ8; Q9BQM0; Q9BQM1; Q9BQM5; Q9H5U0; Q9HCI2; Q9NXN9" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3596151466959216240" "False" "High" "IsMasterProtein" "Q9HD45" "Transmembrane 9 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM9SF3 PE=1 SV=2" "0.001" "False" "3.299" "2" "1" "1" "1" "589" "67.8" "7.21" "2.64" "1" "other biological processes" "other membranes" "" "Pf02990" "56889" "ENSG00000077147" "TM9SF3" "hsa:56889; Q5TB57; Q6UWE7; Q9HD45; Q9NWL8; Q9P0G9; Q9UHW8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.001" "False" "3.290" "15" "2" "2" "2" "101" "11.5" "9.33" "5.21" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "" "HATs acetylate histones" "1" "0" "1.122" "0.908" "1.078" "1.083" "1.070" "1.132" "0.922" "0.947" "0.985" "136.8" "153.5" "124.2" "147.5" "148.1" "146.4" "154.8" "126.2" "129.6" "134.8" "" "" "" "" "" "" "" "" "" "" "136.8" "129.9" "78.5" "107.6" "121.4" "113.7" "119.4" "108.5" "101.2" "121.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.001" "False" "3.289" "2" "1" "1" "1" "499" "56.3" "7.25" "2.89" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.001" "False" "3.281" "3" "1" "3" "1" "232" "25.8" "9.74" "8.51" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "" "tRNA processing in the nucleus" "1" "0" "1.044" "0.742" "1.171" "1.098" "0.753" "1.165" "1.075" "0.764" "0.981" "257.9" "269.2" "191.2" "301.9" "283.1" "194.1" "300.5" "277.1" "196.9" "253.0" "" "" "" "" "" "" "" "" "" "" "257.9" "227.7" "120.9" "220.1" "231.9" "150.7" "231.7" "238.3" "153.7" "227.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.001" "False" "3.281" "2" "2" "2" "2" "651" "74.7" "7.02" "5.26" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Glycosaminoglycan degradation" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "5" "0" "1.321" "1.213" "1.317" "1.356" "1.000" "1.335" "1.166" "1.286" "1.024" "75.7" "100.0" "91.9" "99.7" "102.7" "75.7" "101.1" "88.3" "97.4" "77.5" "" "" "" "" "" "" "" "" "" "" "75.7" "84.6" "58.1" "72.7" "84.1" "58.8" "77.9" "75.9" "76.0" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4835806217438690237" "False" "High" "IsMasterProtein" "Q9Y2K5" "R3H domain-containing protein 2 OS=Homo sapiens OX=9606 GN=R3HDM2 PE=1 SV=3" "0.001" "False" "3.280" "1" "1" "1" "1" "976" "106.9" "8.85" "2.76" "1" "" "nucleus" "" "Pf01424" "22864" "ENSG00000179912" "R3HDM2" "B7ZL65; hsa:22864; Q2M1T9; Q3ZCT5; Q9Y2K5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344595424207440426" "False" "High" "IsMasterProtein" "Q96RT8" "Gamma-tubulin complex component 5 OS=Homo sapiens OX=9606 GN=TUBGCP5 PE=1 SV=1" "0.001" "False" "3.275" "1" "1" "1" "1" "1024" "118.2" "5.90" "3.17" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681" "114791" "ENSG00000275835" "TUBGCP5" "E9PB12; hsa:114791; Q6IQ52; Q96PY8; Q96RT8" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8889272797840220039" "False" "High" "IsMasterProtein" "Q9UBZ9" "DNA repair protein REV1 OS=Homo sapiens OX=9606 GN=REV1 PE=1 SV=1" "0.001" "False" "3.275" "1" "2" "2" "2" "1251" "138.2" "8.51" "5.19" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00817, Pf11799, Pf14377, Pf16727, Pf21704" "51455" "ENSG00000135945" "REV1" "hsa:51455; O95941; Q53SI7; Q9C0J4; Q9NUP2; Q9UBZ9" "DNA repair pathways, full network" "Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI" "5" "0" "0.830" "0.750" "0.815" "0.839" "0.884" "1.071" "0.900" "0.824" "0.892" "88.0" "73.0" "66.0" "71.7" "73.8" "77.8" "94.2" "79.2" "72.5" "78.5" "" "" "" "" "" "" "" "" "" "" "88.0" "61.8" "41.7" "52.3" "60.5" "60.4" "72.6" "68.1" "56.6" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174289831199594781" "False" "High" "IsMasterProtein" "Q2KHR3" "Glutamine and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=QSER1 PE=1 SV=3" "0.001" "False" "3.267" "1" "1" "1" "1" "1735" "189.9" "7.08" "2.16" "1" "" "other cell component" "" "Pf13926" "79832" "" "QSER1" "hsa:79832; Q2KHR3; Q6ZU30; Q6ZUR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.001" "False" "3.267" "3" "1" "1" "1" "274" "28.6" "7.72" "2.97" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "" "Glutamate and glutamine metabolism" "1" "0" "1.144" "1.152" "1.094" "1.110" "0.945" "1.026" "1.042" "1.061" "1.107" "84.6" "96.8" "97.5" "92.5" "93.9" "79.9" "86.8" "88.2" "89.8" "93.6" "" "" "" "" "" "" "" "" "" "" "84.6" "81.9" "61.6" "67.5" "76.9" "62.1" "66.9" "75.8" "70.1" "84.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "High" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.001" "False" "3.254" "1" "2" "2" "2" "1548" "172.7" "6.84" "5.54" "2" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "1.250" "1.052" "0.964" "1.123" "1.046" "0.960" "1.078" "1.251" "0.980" "115.3" "144.1" "121.4" "111.1" "129.5" "120.6" "110.8" "124.3" "144.2" "113.0" "" "" "" "" "" "" "" "" "" "" "115.3" "121.9" "76.8" "81.0" "106.1" "93.7" "85.4" "106.9" "112.6" "101.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7981006517049811851" "False" "High" "IsMasterProtein" "Q8N3Z3" "GTP-binding protein 8 OS=Homo sapiens OX=9606 GN=GTPBP8 PE=1 SV=1" "0.001" "False" "3.250" "4" "1" "1" "1" "284" "32.1" "9.42" "3.10" "1" "" "mitochondrion" "other molecular function" "Pf01926" "29083" "ENSG00000163607" "GTPBP8" "A6NE99; A6NN11; A8K0P6; hsa:29083; Q5I0Y4; Q8N3Z3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "High" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.001" "False" "3.247" "1" "1" "1" "1" "1148" "128.4" "6.62" "2.39" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.108" "0.985" "1.145" "1.370" "1.278" "1.033" "1.077" "1.041" "1.091" "23.2" "25.7" "22.8" "26.5" "31.8" "29.6" "23.9" "25.0" "24.1" "25.3" "" "" "" "" "" "" "" "" "" "" "23.2" "21.7" "14.4" "19.3" "26.0" "23.0" "18.5" "21.5" "18.8" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.001" "False" "3.247" "11" "1" "1" "1" "120" "12.9" "6.67" "2.51" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "Translation factors; Fragile X syndrome" "" "2" "0" "0.923" "0.917" "0.943" "0.927" "0.909" "0.976" "0.869" "0.935" "0.660" "22.2" "20.4" "20.3" "20.9" "20.5" "20.1" "21.6" "19.2" "20.7" "14.6" "" "" "" "" "" "" "" "" "" "" "22.2" "17.3" "12.8" "15.2" "16.8" "15.6" "16.7" "16.5" "16.2" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.001" "False" "3.246" "3" "1" "1" "1" "306" "35.3" "9.03" "3.01" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.001" "False" "3.243" "1" "1" "1" "1" "1328" "148.8" "9.28" "3.25" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112026886534242272" "False" "High" "IsMasterProtein" "Q99653" "Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3" "0.001" "False" "3.237" "6" "1" "1" "1" "195" "22.4" "5.10" "2.75" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00036" "11261" "ENSG00000187446" "CHP1" "B2R6H9; hsa:11261; Q6FHZ9; Q99653" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "Hyaluronan uptake and degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.001" "False" "3.231" "7" "1" "1" "1" "136" "14.9" "9.31" "2.80" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.001" "False" "3.227" "3" "1" "1" "1" "379" "43.3" "6.99" "3.55" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "Defective GALT can cause GALCT; Galactose catabolism" "4" "0" "0.903" "1.010" "1.077" "1.024" "1.044" "0.999" "1.051" "1.067" "1.066" "127.7" "115.3" "129.0" "137.6" "130.8" "133.3" "127.6" "134.2" "136.2" "136.2" "" "" "" "" "" "" "" "" "" "" "127.7" "97.6" "81.5" "100.3" "107.2" "103.5" "98.4" "115.4" "106.3" "122.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.001" "False" "3.223" "2" "1" "1" "1" "415" "46.9" "6.21" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "" "Metalloprotease DUBs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8120916206400470693" "False" "High" "IsMasterProtein" "O96006" "E3 SUMO-protein ligase ZBED1 OS=Homo sapiens OX=9606 GN=ZBED1 PE=1 SV=1" "0.001" "False" "3.222" "2" "1" "1" "1" "694" "78.1" "6.10" "3.51" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892, Pf05699" "9189" "ENSG00000214717; ENSG00000292345" "ZBED1" "hsa:9189; O96006; Q96BY4" "" "SUMOylation of chromatin organization proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.001" "False" "3.204" "4" "1" "2" "1" "216" "24.5" "5.34" "5.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "" "Unwinding of DNA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2019204481334339745" "False" "High" "IsMasterProtein" "Q9H3R0" "Lysine-specific demethylase 4C OS=Homo sapiens OX=9606 GN=KDM4C PE=1 SV=2" "0.001" "False" "3.199" "1" "1" "1" "1" "1056" "119.9" "6.46" "2.52" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23081" "ENSG00000107077" "KDM4C" "B4E1Y4; B7ZL46; F5H347; F5H7P0; hsa:23081; O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; Q9H3R0" "" "HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.001" "False" "3.198" "2" "1" "1" "1" "450" "51.9" "4.89" "3.41" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy; RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1824813434461880276" "False" "High" "IsMasterProtein" "P84157" "Matrix-remodeling-associated protein 7 OS=Homo sapiens OX=9606 GN=MXRA7 PE=1 SV=1" "0.001" "False" "3.195" "4" "1" "1" "1" "204" "21.5" "4.26" "3.86" "1" "" "other membranes;ER/Golgi" "" "" "439921" "ENSG00000182534" "MXRA7" "hsa:439921; P84157; Q0P5W3" "" "" "0" "0" "0.964" "0.975" "0.850" "1.141" "0.919" "1.286" "0.858" "0.771" "0.983" "167.7" "161.6" "163.4" "142.6" "191.4" "154.1" "215.7" "143.9" "129.4" "164.9" "" "" "" "" "" "" "" "" "" "" "167.7" "136.7" "103.3" "104.0" "156.8" "119.6" "166.3" "123.7" "101.0" "148.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4859548127155767748" "False" "High" "IsMasterProtein" "A1A4S6" "Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1" "0.001" "False" "3.192" "1" "1" "1" "1" "786" "89.3" "7.18" "2.62" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00169, Pf00620, Pf14604, Pf16746" "79658" "ENSG00000071205" "ARHGAP10" "A1A4S6; A1L0S5; hsa:79658; Q2VPC4; Q2VPC5; Q96EV3; Q96S75" "Ectoderm differentiation; Ectoderm differentiation" "Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "6" "0" "1.048" "0.918" "1.068" "1.165" "0.932" "1.240" "1.001" "1.018" "0.888" "12.8" "13.4" "11.8" "13.7" "15.0" "12.0" "15.9" "12.8" "13.1" "11.4" "" "" "" "" "" "" "" "" "" "" "12.8" "11.4" "7.4" "10.0" "12.2" "9.3" "12.3" "11.0" "10.2" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1208810271641948454" "False" "High" "IsMasterProtein" "Q8NEL9" "Phospholipase DDHD1 OS=Homo sapiens OX=9606 GN=DDHD1 PE=1 SV=2" "0.001" "False" "3.182" "1" "1" "1" "1" "900" "100.4" "5.67" "3.36" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02862" "80821" "ENSG00000100523" "DDHD1" "G5E9D1; hsa:80821; Q8NEL9; Q8WVH3; Q96LL2; Q9C0F8" "" "Synthesis of PA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.001" "False" "3.179" "12" "1" "1" "1" "91" "10.8" "10.73" "3.15" "1" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "High" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.001" "False" "3.176" "3" "1" "1" "1" "466" "53.0" "6.40" "2.94" "1" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.001" "False" "3.171" "13" "1" "1" "1" "61" "6.1" "7.96" "3.77" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "Metallothioneins bind metals" "4" "0" "0.850" "1.134" "0.919" "0.830" "1.100" "1.105" "0.907" "1.133" "0.889" "180.7" "153.6" "205.0" "166.1" "150.0" "198.7" "199.6" "163.8" "204.7" "160.7" "" "" "" "" "" "" "" "" "" "" "180.7" "130.0" "129.6" "121.1" "122.9" "154.3" "153.9" "140.8" "159.8" "144.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.001" "False" "3.165" "3" "1" "1" "1" "274" "30.3" "7.15" "3.19" "1" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.240" "1.331" "1.156" "1.022" "1.189" "1.079" "0.959" "1.303" "1.081" "144.9" "179.7" "192.9" "167.5" "148.1" "172.3" "156.4" "139.0" "188.9" "156.6" "" "" "" "" "" "" "" "" "" "" "144.9" "152.1" "121.9" "122.1" "121.4" "133.8" "120.5" "119.5" "147.4" "140.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414288998537041680" "False" "High" "IsMasterProtein" "Q9UK53" "Inhibitor of growth protein 1 OS=Homo sapiens OX=9606 GN=ING1 PE=1 SV=2" "0.001" "False" "3.165" "2" "1" "1" "1" "422" "46.7" "9.06" "3.57" "1" "cell cycle OR cell proliferation;transport;other biological processes" "nucleus" "other molecular function" "Pf12998" "3621" "ENSG00000153487" "ING1" "hsa:3621; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52; Q9UK53" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528813137520318057" "False" "High" "IsMasterProtein" "Q9UBG0" "C-type mannose receptor 2 OS=Homo sapiens OX=9606 GN=MRC2 PE=1 SV=2" "0.001" "False" "3.164" "1" "1" "1" "1" "1479" "166.6" "5.83" "2.23" "1" "other metabolic processes;transport" "" "other molecular function" "Pf00040, Pf00059" "9902" "ENSG00000011028" "MRC2" "A6H8K4; D3DU08; hsa:9902; Q7LGE7; Q9UBG0; Q9Y5P9" "" "Cross-presentation of soluble exogenous antigens (endosomes)" "1" "0" "1.282" "1.067" "1.202" "1.290" "1.025" "1.135" "1.445" "1.251" "1.214" "37.9" "48.6" "40.5" "45.6" "48.9" "38.9" "43.0" "54.8" "47.4" "46.0" "" "" "" "" "" "" "" "" "" "" "37.9" "41.1" "25.6" "33.2" "40.1" "30.2" "33.2" "47.1" "37.0" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.001" "False" "3.163" "8" "1" "1" "1" "140" "14.6" "8.46" "4.04" "1" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "0.942" "0.802" "0.935" "1.096" "0.844" "0.963" "0.925" "0.968" "0.860" "93.7" "88.3" "75.2" "87.5" "102.7" "79.0" "90.2" "86.6" "90.6" "80.6" "" "" "" "" "" "" "" "" "" "" "93.7" "74.7" "47.5" "63.8" "84.1" "61.4" "69.5" "74.5" "70.8" "72.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.001" "False" "3.163" "2" "1" "1" "1" "411" "46.5" "6.96" "3.49" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "" "Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Expression and translocation of olfactory receptors; Cardiogenesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6761620060411252827" "False" "High" "IsMasterProtein" "Q9HBH0" "Rho-related GTP-binding protein RhoF OS=Homo sapiens OX=9606 GN=RHOF PE=1 SV=1" "0.001" "False" "3.160" "4" "1" "1" "1" "211" "23.6" "8.65" "3.72" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "enzyme regulator activity;other molecular function" "Pf00071" "54509" "ENSG00000139725" "RHOF" "hsa:54509; Q8WVB1; Q9HBH0; Q9NXH6" "" "Neutrophil degranulation; RHOF GTPase cycle" "2" "0" "1.032" "1.130" "1.149" "1.004" "0.980" "1.041" "1.218" "1.035" "1.080" "109.3" "112.8" "123.5" "125.6" "109.8" "107.1" "113.8" "133.1" "113.2" "118.0" "" "" "" "" "" "" "" "" "" "" "109.3" "95.5" "78.1" "91.6" "89.9" "83.2" "87.8" "114.5" "88.3" "106.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1022536969773821467" "False" "High" "IsMasterProtein" "P20702" "Integrin alpha-X OS=Homo sapiens OX=9606 GN=ITGAX PE=1 SV=3" "0.001" "False" "3.159" "1" "1" "1" "1" "1163" "127.7" "6.64" "3.24" "1" "cell adhesion;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00357, Pf01839, Pf08441, Pf20805, Pf21520" "3687" "ENSG00000140678" "ITGAX" "hsa:3687; P20702; Q8IVA6" "Integrin-mediated cell adhesion; Complement system; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; TYROBP causal network in microglia; Complement system in neuronal development and plasticity; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; Interleukin-4 and Interleukin-13 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120350254176484171" "False" "High" "IsMasterProtein" "A6NGB0" "Transmembrane protein 191C OS=Homo sapiens OX=9606 GN=TMEM191C PE=1 SV=3" "0.001" "False" "3.158" "2" "1" "1" "1" "302" "34.8" "5.16" "0.00" "1" "" "other membranes" "" "Pf14992, Pf15194" "" "ENSG00000206140" "TMEM191C" "A0A1B0GW53; A6NGB0; hsa:645426" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4170065577155678868" "False" "High" "IsMasterProtein" "Q5QP82" "DDB1- and CUL4-associated factor 10 OS=Homo sapiens OX=9606 GN=DCAF10 PE=1 SV=1" "0.001" "False" "3.152" "2" "1" "1" "1" "559" "60.5" "7.50" "2.25" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "79269" "ENSG00000122741" "DCAF10" "A4VCJ5; hsa:79269; Q32NE2; Q5QP82; Q8N2Q5; Q96ET5; Q9BTQ5; Q9H5P6" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "High" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.001" "False" "3.151" "5" "1" "2" "1" "274" "30.3" "5.97" "2.59" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "Neutrophil degranulation; Interleukin-1 signaling" "7" "0" "1.593" "1.360" "1.551" "1.404" "1.083" "0.945" "0.886" "0.903" "1.523" "12.0" "19.1" "16.3" "18.6" "16.8" "13.0" "11.3" "10.6" "10.8" "18.2" "" "" "" "" "" "" "" "" "" "" "12.0" "16.1" "10.3" "13.5" "13.8" "10.1" "8.7" "9.1" "8.4" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925318187336607023" "False" "High" "IsMasterProtein" "Q32M84" "BTB/POZ domain-containing protein 16 OS=Homo sapiens OX=9606 GN=BTBD16 PE=1 SV=2" "0.001" "False" "3.140" "4" "2" "2" "1" "506" "58.4" "9.20" "4.26" "2" "" "" "" "Pf21059" "118663" "ENSG00000138152" "BTBD16" "A6NM63; hsa:118663; Q32M84; Q4VXL1; Q96LN0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "High" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.001" "False" "3.128" "0" "2" "5" "2" "5142" "560.4" "6.47" "13.08" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea" "2" "0" "0.963" "0.982" "1.019" "1.002" "0.873" "0.858" "0.971" "1.072" "0.925" "97.2" "93.6" "95.4" "99.1" "97.4" "84.8" "83.4" "94.4" "104.2" "89.9" "" "" "" "" "" "" "" "" "" "" "97.2" "79.2" "60.3" "72.2" "79.8" "65.9" "64.3" "81.1" "81.3" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.001" "False" "3.126" "13" "1" "1" "1" "67" "7.6" "7.77" "3.79" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "56" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564730176707544032" "False" "High" "IsMasterProtein" "O95479" "GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2" "0.001" "False" "3.122" "1" "1" "2" "1" "791" "88.8" "7.30" "5.06" "1" "other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00479, Pf01182, Pf02781" "9563" "ENSG00000049239" "H6PD" "hsa:9563; O95479; Q4TT33; Q66I35; Q68DT3; R4GMU1" "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism" "" "1" "0" "1.308" "1.203" "1.117" "1.214" "1.322" "1.213" "1.116" "1.343" "1.202" "51.8" "67.8" "62.3" "57.9" "62.9" "68.5" "62.9" "57.8" "69.6" "62.3" "" "" "" "" "" "" "" "" "" "" "51.8" "57.4" "39.4" "42.2" "51.6" "53.2" "48.4" "49.7" "54.3" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.001" "False" "3.114" "22" "2" "2" "2" "111" "12.0" "9.83" "1.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "" "Termination of translesion DNA synthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5478357759493696038" "False" "High" "IsMasterProtein" "Q16584" "Mitogen-activated protein kinase kinase kinase 11 OS=Homo sapiens OX=9606 GN=MAP3K11 PE=1 SV=1" "0.001" "False" "3.110" "1" "1" "1" "1" "847" "92.6" "8.12" "3.14" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf07714, Pf14604" "4296" "ENSG00000173327" "MAP3K11" "B4DS76; hsa:4296; Q16584; Q53H00; Q59F06; Q6P2G4" "MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma" "CDC42 GTPase cycle; RHOG GTPase cycle; RHOV GTPase cycle; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.001" "False" "3.104" "1" "1" "1" "1" "620" "70.5" "5.73" "3.22" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "1.170" "1.299" "1.104" "1.146" "1.396" "1.138" "1.162" "1.367" "1.111" "89.4" "104.6" "116.2" "98.7" "102.4" "124.9" "101.8" "103.9" "122.2" "99.4" "" "" "" "" "" "" "" "" "" "" "89.4" "88.5" "73.4" "72.0" "83.9" "97.0" "78.4" "89.3" "95.4" "89.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.001" "False" "3.104" "1" "1" "1" "1" "621" "68.7" "7.96" "3.32" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.001" "False" "3.103" "2" "2" "2" "2" "771" "87.9" "7.87" "4.94" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.980" "1.158" "1.042" "1.196" "1.216" "1.043" "1.157" "1.198" "1.086" "88.6" "86.8" "102.6" "92.3" "106.0" "107.7" "92.4" "102.5" "106.1" "96.2" "" "" "" "" "" "" "" "" "" "" "88.6" "73.5" "64.9" "67.3" "86.8" "83.7" "71.2" "88.1" "82.8" "86.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011686902353610677" "False" "High" "IsMasterProtein" "Q8NBI5" "Equilibrative nucleobase transporter 1 OS=Homo sapiens OX=9606 GN=SLC43A3 PE=1 SV=2" "0.001" "False" "3.100" "2" "1" "1" "1" "491" "54.5" "8.53" "3.46" "1" "transport" "plasma membrane;other membranes" "transporter activity" "" "29015" "ENSG00000134802" "SLC43A3" "B4DNR8; E7EQD2; hsa:29015; Q8NBI5; Q9NSS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.001" "False" "3.099" "4" "2" "2" "2" "753" "84.4" "9.57" "2.35" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Complement system in neuronal development and plasticity" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "10" "0" "1.017" "0.978" "0.932" "1.569" "1.096" "1.212" "1.151" "1.103" "1.112" "22.4" "22.8" "21.9" "20.9" "35.2" "24.6" "27.2" "25.8" "24.7" "24.9" "" "" "" "" "" "" "" "" "" "" "22.4" "19.3" "13.9" "15.2" "28.8" "19.1" "20.9" "22.2" "19.3" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.001" "False" "3.090" "11" "2" "2" "2" "176" "18.7" "9.09" "4.79" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Vitamin B12 metabolism" "Propionyl-CoA catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4022376780209334762" "False" "High" "IsMasterProtein" "Q96EM0" "Trans-3-hydroxy-L-proline dehydratase OS=Homo sapiens OX=9606 GN=L3HYPDH PE=1 SV=2" "0.001" "False" "3.083" "3" "1" "2" "1" "354" "38.1" "6.68" "4.60" "1" "" "" "other molecular function" "Pf05544" "112849" "ENSG00000126790" "L3HYPDH" "hsa:112849; Q96EM0; Q96LJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.001" "False" "3.081" "2" "1" "2" "1" "393" "43.5" "5.77" "5.33" "1" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "1.093" "0.881" "1.250" "1.023" "1.060" "1.290" "1.170" "1.252" "1.084" "45.8" "50.0" "40.3" "57.2" "46.8" "48.5" "59.0" "53.5" "57.3" "49.6" "" "" "" "" "" "" "" "" "" "" "45.8" "42.3" "25.5" "41.7" "38.3" "37.7" "45.5" "46.0" "44.7" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.001" "False" "3.081" "3" "1" "1" "1" "268" "29.0" "6.43" "3.20" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "0.941" "0.941" "0.968" "1.473" "1.093" "1.543" "1.063" "1.042" "0.963" "118.1" "111.1" "111.1" "114.3" "173.9" "129.0" "182.3" "125.6" "123.1" "113.7" "" "" "" "" "" "" "" "" "" "" "118.1" "94.0" "70.3" "83.3" "142.5" "100.2" "140.5" "108.0" "96.1" "102.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.002" "False" "3.076" "6" "1" "1" "1" "133" "15.5" "6.06" "3.36" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "0.894" "0.839" "1.043" "1.012" "0.991" "1.186" "0.988" "0.885" "0.889" "161.7" "144.6" "135.6" "168.6" "163.7" "160.2" "191.7" "159.7" "143.2" "143.8" "" "" "" "" "" "" "" "" "" "" "161.7" "122.3" "85.7" "122.9" "134.1" "124.4" "147.8" "137.3" "111.8" "129.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.002" "False" "3.075" "4" "1" "2" "1" "213" "23.1" "8.51" "6.11" "1" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "1.039" "0.921" "1.139" "1.110" "0.985" "1.289" "1.109" "0.799" "0.902" "117.6" "122.1" "108.3" "133.9" "130.4" "115.8" "151.6" "130.3" "94.0" "106.0" "" "" "" "" "" "" "" "" "" "" "117.6" "103.3" "68.5" "97.6" "106.9" "89.9" "116.8" "112.1" "73.4" "95.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7557449725087676483" "False" "High" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "0.002" "False" "3.072" "2" "1" "1" "1" "529" "60.2" "6.54" "3.65" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21237, Pf21238" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "0.793" "0.932" "0.806" "0.952" "1.012" "0.833" "0.842" "1.026" "0.894" "121.7" "96.5" "113.4" "98.1" "115.9" "123.2" "101.4" "102.4" "124.8" "108.7" "" "" "" "" "" "" "" "" "" "" "121.7" "81.6" "71.7" "71.5" "94.9" "95.7" "78.2" "88.0" "97.4" "97.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396130811194437516" "False" "High" "IsMasterProtein" "O15254" "Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens OX=9606 GN=ACOX3 PE=1 SV=2" "0.002" "False" "3.066" "1" "1" "1" "1" "700" "77.6" "7.25" "2.60" "1" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770" "8310" "ENSG00000087008" "ACOX3" "hsa:8310; O15254; Q96AJ8" "PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA" "6" "0" "1.175" "0.952" "1.267" "1.034" "0.945" "1.300" "1.284" "1.139" "0.952" "114.2" "134.1" "108.6" "144.7" "118.1" "107.9" "148.4" "146.6" "130.0" "108.7" "" "" "" "" "" "" "" "" "" "" "114.2" "113.5" "68.7" "105.5" "96.8" "83.8" "114.4" "126.0" "101.5" "97.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-142769344711843061" "False" "High" "IsMasterProtein" "P60468" "Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2" "0.002" "False" "3.062" "11" "1" "1" "1" "96" "10.0" "11.56" "2.15" "1" "protein metabolism;other metabolic processes;stress response;transport" "other membranes;cytosol;ER/Golgi" "translation activity;other molecular function" "Pf03911" "10952" "ENSG00000106803" "SEC61B" "hsa:10952; P38390; P38391; P60468; Q6IBC1" "" "ER-Phagosome pathway; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; SRP-dependent cotranslational protein targeting to membrane" "3" "0" "0.926" "0.612" "0.906" "0.773" "0.733" "0.961" "0.764" "0.593" "0.853" "57.5" "53.3" "35.2" "52.1" "44.5" "42.2" "55.3" "44.0" "34.1" "49.1" "" "" "" "" "" "" "" "" "" "" "57.5" "45.1" "22.3" "38.0" "36.4" "32.7" "42.6" "37.8" "26.6" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394977433117342737" "False" "High" "IsMasterProtein" "Q92859" "Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2" "0.002" "False" "3.059" "1" "1" "1" "1" "1461" "159.9" "6.54" "2.18" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf06583, Pf07679, Pf13895, Pf13927" "4756" "ENSG00000067141" "NEO1" "B7ZKM9; B7ZKN0; hsa:4756; O00340; Q17RX1; Q92859" "Splicing factor NOVA regulated synaptic proteins; Netrin-UNC5B signaling pathway; 10q11.21q11.23 copy number variation syndrome" "Myogenesis; Netrin-1 signaling" "5" "0" "1.002" "0.727" "1.120" "0.857" "0.789" "1.147" "0.863" "0.680" "0.973" "24.1" "24.1" "17.5" "27.0" "20.6" "19.0" "27.6" "20.8" "16.4" "23.4" "" "" "" "" "" "" "" "" "" "" "24.1" "20.4" "11.1" "19.7" "16.9" "14.7" "21.3" "17.9" "12.8" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6372570130755295238" "False" "High" "IsMasterProtein" "Q5XUX0" "F-box only protein 31 OS=Homo sapiens OX=9606 GN=FBXO31 PE=1 SV=2" "0.002" "False" "3.057" "2" "1" "1" "1" "539" "60.6" "7.02" "3.16" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction" "cytosol;other cell component" "other molecular function" "Pf12014, Pf12937" "79791" "ENSG00000103264" "FBXO31" "hsa:79791; Q5K680; Q5XUX0; Q8WYV1; Q96D73; Q9UFV4" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.220" "0.817" "1.157" "1.207" "0.868" "0.887" "1.199" "0.757" "1.031" "36.6" "44.6" "29.9" "42.3" "44.1" "31.7" "32.4" "43.9" "27.7" "37.7" "" "" "" "" "" "" "" "" "" "" "36.6" "37.7" "18.9" "30.8" "36.2" "24.6" "25.0" "37.7" "21.6" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447255440292633936" "False" "High" "IsMasterProtein" "Q92625" "Ankyrin repeat and SAM domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKS1A PE=1 SV=4" "0.002" "False" "3.054" "1" "2" "2" "2" "1134" "123.0" "6.38" "4.91" "2" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00023, Pf00536, Pf00640" "23294" "ENSG00000064999" "ANKS1A" "A2RUC1; B4DQW8; hsa:23294; Q5JYI9; Q5SYR2; Q86WQ7; Q92625" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "High" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.002" "False" "3.052" "3" "1" "2" "1" "292" "33.2" "6.70" "4.16" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "" "MicroRNA (miRNA) biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681183959761710458" "False" "High" "IsMasterProtein" "Q96G28" "Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2" "0.002" "False" "3.048" "3" "1" "1" "1" "342" "39.4" "4.97" "3.13" "1" "" "cytoskeleton;nucleus;other cell component" "" "Pf11527" "112942" "ENSG00000163001" "CFAP36" "hsa:112942; Q53SF0; Q53ST9; Q6UY34; Q96G28" "" "" "0" "0" "0.820" "0.582" "0.880" "0.881" "0.871" "0.989" "0.946" "0.876" "0.769" "30.8" "25.2" "17.9" "27.1" "27.1" "26.8" "30.5" "29.1" "27.0" "23.7" "" "" "" "" "" "" "" "" "" "" "30.8" "21.4" "11.3" "19.8" "22.2" "20.8" "23.5" "25.1" "21.1" "21.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-357583033537535039" "False" "High" "IsMasterProtein" "Q9NX20" "Large ribosomal subunit protein uL16m OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1" "0.002" "False" "3.048" "3" "1" "1" "1" "251" "28.4" "10.13" "2.82" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00252" "54948" "ENSG00000166902" "MRPL16" "hsa:54948; Q9BYD0; Q9HB70; Q9NX20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144210320745121937" "False" "High" "IsMasterProtein" "Q5T1J5" "Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD2P9 PE=5 SV=1" "0.002" "False" "3.046" "9" "1" "1" "1" "151" "15.5" "9.89" "3.58" "1" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "" "" "" "CHCHD2P9" "Q5T1J5" "" "" "0" "0" "1.324" "0.976" "1.156" "1.274" "1.376" "1.220" "1.151" "1.068" "1.087" "79.5" "105.3" "77.7" "92.0" "101.3" "109.4" "97.0" "91.5" "84.9" "86.4" "" "" "" "" "" "" "" "" "" "" "79.5" "89.1" "49.1" "67.1" "83.0" "85.0" "74.8" "78.7" "66.3" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.002" "False" "3.044" "4" "1" "1" "1" "201" "22.7" "5.17" "2.61" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "5q35 copy number variation" "COPII-mediated vesicle transport; Cargo concentration in the ER; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Pre-NOTCH Processing in Golgi" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3701102835141245935" "False" "High" "IsMasterProtein" "Q9HBH9" "MAP kinase-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MKNK2 PE=1 SV=3" "0.002" "False" "3.041" "2" "1" "1" "1" "465" "51.8" "6.19" "3.02" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "2872" "ENSG00000099875" "MKNK2" "hsa:2872; Q6GPI3; Q9HBH8; Q9HBH9; Q9UHR0; Q9Y2N6" "Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Pleural mesothelioma" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1879188943006423964" "False" "High" "IsMasterProtein" "A8MSI8" "LYR motif-containing protein 9 OS=Homo sapiens OX=9606 GN=LYRM9 PE=1 SV=2" "0.002" "False" "3.036" "13" "1" "1" "1" "78" "9.4" "9.66" "2.64" "1" "" "" "" "Pf05347" "201229" "ENSG00000232859" "LYRM9" "A6NJT7; A8MSI8; hsa:201229; Q6X7B8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.002" "False" "3.033" "2" "1" "1" "1" "525" "59.1" "6.65" "2.71" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.002" "False" "3.033" "4" "1" "1" "1" "268" "30.8" "7.39" "2.64" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.002" "False" "3.033" "5" "2" "3" "2" "291" "32.5" "9.14" "6.96" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "" "Phase I - Functionalization of compounds" "1" "0" "1.419" "1.344" "1.204" "1.348" "1.533" "1.232" "0.908" "0.851" "1.241" "15.8" "22.4" "21.2" "19.0" "21.2" "24.2" "19.4" "14.3" "13.4" "19.6" "" "" "" "" "" "" "" "" "" "" "15.8" "18.9" "13.4" "13.8" "17.4" "18.8" "15.0" "12.3" "10.5" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.002" "False" "3.031" "1" "1" "1" "1" "648" "72.6" "5.21" "3.17" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "" "TBC/RABGAPs" "1" "0" "1.030" "0.785" "1.024" "1.149" "0.890" "1.059" "0.906" "0.909" "0.915" "81.6" "84.1" "64.1" "83.6" "93.8" "72.7" "86.5" "73.9" "74.3" "74.7" "" "" "" "" "" "" "" "" "" "" "81.6" "71.1" "40.5" "60.9" "76.9" "56.4" "66.7" "63.6" "58.0" "67.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1997120607862774840" "False" "High" "IsMasterProtein" "O00189" "AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2" "0.002" "False" "3.028" "4" "2" "2" "2" "453" "49.9" "7.20" "4.69" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00928, Pf01217" "9179" "ENSG00000221838" "AP4M1" "D6W5U1; hsa:9179; O00189; Q8WV65; Q9UHK9" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.115" "1.228" "0.968" "1.110" "1.070" "1.291" "1.187" "1.162" "1.171" "47.5" "53.0" "58.4" "46.0" "52.8" "50.9" "61.4" "56.4" "55.2" "55.7" "" "" "" "" "" "" "" "" "" "" "47.5" "44.8" "36.9" "33.5" "43.2" "39.5" "47.3" "48.5" "43.1" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890880560088896106" "False" "High" "IsMasterProtein" "Q8NFZ5" "TNFAIP3-interacting protein 2 OS=Homo sapiens OX=9606 GN=TNIP2 PE=1 SV=1" "0.002" "False" "3.020" "3" "1" "1" "1" "429" "48.7" "6.44" "2.09" "1" "stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12180" "79155" "ENSG00000168884" "TNIP2" "B1AKS4; B3KTY8; D3DVQ9; hsa:79155; Q7L5L2; Q8NFZ5; Q9BQR6; Q9H682" "RAC1/PAK1/p38/MMP2 pathway" "MAP3K8 (TPL2)-dependent MAPK1/3 activation; Ovarian tumor domain proteases" "3" "0" "0.901" "1.033" "1.065" "1.170" "1.055" "1.156" "0.964" "0.853" "1.150" "42.8" "38.6" "44.2" "45.6" "50.1" "45.1" "49.4" "41.2" "36.5" "49.2" "" "" "" "" "" "" "" "" "" "" "42.8" "32.6" "27.9" "33.2" "41.0" "35.0" "38.1" "35.4" "28.5" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6678202250508335411" "False" "High" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "0.002" "False" "3.018" "3" "1" "1" "1" "278" "31.8" "5.53" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.041" "0.936" "1.159" "1.002" "0.926" "1.162" "1.124" "1.164" "0.936" "50.7" "52.8" "47.4" "58.7" "50.8" "46.9" "58.9" "57.0" "59.0" "47.5" "" "" "" "" "" "" "" "" "" "" "50.7" "44.6" "30.0" "42.8" "41.6" "36.4" "45.4" "49.0" "46.1" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011700536364298071" "False" "High" "IsMasterProtein" "Q8TBQ9" "Protein kish-A OS=Homo sapiens OX=9606 GN=TMEM167A PE=1 SV=1" "0.002" "False" "3.016" "13" "1" "1" "1" "72" "8.1" "8.95" "3.18" "1" "transport" "other membranes;ER/Golgi" "" "Pf06842" "153339" "ENSG00000174695" "TMEM167A" "hsa:153339; Q0P692; Q8TBQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1253953420551710594" "False" "High" "IsMasterProtein" "Q8TAA5" "GrpE protein homolog 2, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL2 PE=1 SV=1" "0.002" "False" "3.000" "4" "1" "1" "1" "225" "25.4" "7.72" "3.20" "1" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf01025" "134266" "ENSG00000164284" "GRPEL2" "B4DFA6; hsa:134266; Q49AJ6; Q8TAA5" "" "Mitochondrial protein import" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1500672588244887756" "False" "High" "IsMasterProtein" "P05089" "Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2" "0.002" "False" "2.994" "3" "1" "1" "1" "322" "34.7" "7.21" "3.18" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00491" "383" "ENSG00000118520" "ARG1" "A6NEA0; hsa:383; P05089; Q5JWT5; Q5JWT6; Q8TE72; Q9BS50" "Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway" "Neutrophil degranulation; Urea cycle" "5" "0" "1.376" "0.578" "0.474" "0.470" "0.504" "0.479" "0.367" "0.871" "0.451" "53.6" "73.8" "31.0" "25.4" "25.2" "27.0" "25.7" "19.7" "46.7" "24.2" "" "" "" "" "" "" "" "" "" "" "53.6" "62.4" "19.6" "18.6" "20.6" "21.0" "19.8" "16.9" "36.5" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7332918538450832394" "False" "High" "IsMasterProtein" "P18847" "Cyclic AMP-dependent transcription factor ATF-3 OS=Homo sapiens OX=9606 GN=ATF3 PE=1 SV=2" "0.002" "False" "2.985" "6" "1" "1" "1" "181" "20.6" "8.54" "3.93" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "467" "ENSG00000162772" "ATF3" "hsa:467; P18847; Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6" "Myometrial relaxation and contraction pathways; Photodynamic therapy-induced unfolded protein response; TGF-beta signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; IL-18 signaling pathway; Pleural mesothelioma; CCL18 signaling pathway; Hypertrophy model" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "11" "0" "1.306" "1.098" "1.430" "1.458" "1.903" "1.494" "1.521" "1.261" "1.380" "78.6" "102.6" "86.3" "112.4" "114.5" "149.6" "117.4" "119.5" "99.1" "108.5" "" "" "" "" "" "" "" "" "" "" "78.6" "86.8" "54.6" "82.0" "93.8" "116.1" "90.5" "102.8" "77.4" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.002" "False" "2.985" "2" "1" "1" "1" "395" "43.9" "5.99" "3.10" "1" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "1.128" "1.181" "1.138" "1.118" "0.909" "1.306" "1.042" "1.084" "0.982" "89.0" "100.5" "105.2" "101.3" "99.5" "80.9" "116.2" "92.8" "96.5" "87.5" "" "" "" "" "" "" "" "" "" "" "89.0" "85.0" "66.5" "73.8" "81.5" "62.8" "89.6" "79.8" "75.3" "78.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449078799256658420" "False" "High" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "0.002" "False" "2.984" "5" "2" "3" "2" "332" "35.5" "7.17" "5.81" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.002" "False" "2.980" "1" "1" "1" "1" "1210" "132.3" "5.45" "2.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.002" "False" "2.979" "2" "1" "1" "1" "396" "45.3" "9.19" "3.52" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Energy metabolism; Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "4" "0" "1.172" "1.009" "1.143" "1.176" "1.139" "1.318" "1.099" "1.076" "1.019" "83.9" "98.3" "84.6" "95.9" "98.7" "95.5" "110.6" "92.2" "90.3" "85.5" "" "" "" "" "" "" "" "" "" "" "83.9" "83.2" "53.5" "69.9" "80.8" "74.2" "85.2" "79.3" "70.5" "76.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6470413876399214347" "False" "High" "IsMasterProtein" "Q9NSK7" "Protein C19orf12 OS=Homo sapiens OX=9606 GN=C19orf12 PE=1 SV=4" "0.002" "False" "2.978" "7" "1" "1" "1" "141" "15.0" "5.90" "2.85" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.002" "False" "2.976" "2" "1" "1" "1" "351" "38.5" "5.41" "3.16" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "1.039" "0.940" "1.128" "1.047" "0.906" "1.158" "1.045" "0.876" "1.026" "119.4" "124.1" "112.2" "134.7" "125.0" "108.2" "138.3" "124.8" "104.6" "122.6" "" "" "" "" "" "" "" "" "" "" "119.4" "105.0" "70.9" "98.2" "102.4" "84.0" "106.6" "107.3" "81.7" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4124331423707824926" "False" "High" "IsMasterProtein" "Q8N4S0" "Coiled-coil domain-containing protein 82 OS=Homo sapiens OX=9606 GN=CCDC82 PE=1 SV=2" "0.002" "False" "2.969" "2" "1" "1" "1" "544" "64.0" "5.01" "2.90" "1" "" "nucleus" "" "Pf13846, Pf13926" "79780" "ENSG00000149231" "CCDC82" "B3KPU7; hsa:79780; Q8N4S0; Q8WV71; Q9H2Q5; Q9H5E3" "" "" "0" "0" "1.073" "0.852" "0.998" "1.197" "1.027" "1.154" "1.077" "0.985" "1.090" "72.2" "77.5" "61.5" "72.1" "86.5" "74.2" "83.4" "77.8" "71.2" "78.7" "" "" "" "" "" "" "" "" "" "" "72.2" "65.6" "38.9" "52.6" "70.9" "57.6" "64.3" "66.9" "55.5" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.002" "False" "2.966" "3" "1" "1" "1" "437" "45.9" "5.63" "2.34" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4926655616225133563" "False" "High" "IsMasterProtein" "Q86TI0" "TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2" "0.002" "False" "2.963" "1" "1" "1" "1" "1168" "133.0" "6.96" "2.87" "1" "" "nucleus" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "23216" "ENSG00000065882" "TBC1D1" "B7Z3D9; E9PGH8; hsa:23216; Q86TI0; Q96K82; Q9UPP4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "2" "0" "0.884" "0.906" "1.083" "1.077" "1.170" "1.104" "1.150" "0.864" "1.130" "25.0" "22.1" "22.7" "27.1" "26.9" "29.3" "27.6" "28.8" "21.6" "28.2" "" "" "" "" "" "" "" "" "" "" "25.0" "18.7" "14.3" "19.7" "22.1" "22.7" "21.3" "24.7" "16.9" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550245044930584374" "False" "High" "IsMasterProtein" "O60583" "Cyclin-T2 OS=Homo sapiens OX=9606 GN=CCNT2 PE=1 SV=2" "0.002" "False" "2.959" "1" "1" "1" "1" "730" "81.0" "8.92" "2.56" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "905" "ENSG00000082258" "CCNT2" "A8KA48; D3DP73; D3DP74; hsa:905; O60582; O60583; Q29R66; Q53SR4; Q5I1Y0" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "1.104" "0.752" "1.126" "1.174" "0.840" "1.187" "1.151" "1.062" "0.882" "60.1" "66.3" "45.2" "67.7" "70.5" "50.5" "71.3" "69.2" "63.8" "53.0" "" "" "" "" "" "" "" "" "" "" "60.1" "56.1" "28.6" "49.3" "57.8" "39.2" "54.9" "59.5" "49.8" "47.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480743538418204073" "False" "High" "IsMasterProtein" "Cont_P02777" "Platelet factor 4 OS=Bos taurus OX=9913 GN=PF4 PE=1 SV=1" "0.002" "True" "2.943" "9" "1" "1" "1" "88" "9.5" "6.52" "3.19" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00048" "" "" "PF4" "P02777" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.002" "False" "2.940" "3" "1" "1" "1" "325" "37.5" "7.06" "2.98" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801865805934873113" "False" "High" "IsMasterProtein" "Q86YR5" "G-protein-signaling modulator 1 OS=Homo sapiens OX=9606 GN=GPSM1 PE=1 SV=2" "0.002" "False" "2.939" "1" "1" "1" "1" "675" "74.5" "6.54" "3.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf02188, Pf13424" "26086" "ENSG00000160360" "GPSM1" "A9Z1X4; B1B0W3; hsa:26086; Q86SR5; Q86YR5; Q969T1; Q9UFS8" "" "G alpha (i) signalling events" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "High" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.002" "False" "2.939" "4" "1" "1" "1" "213" "23.5" "9.99" "3.33" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "High" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.002" "False" "2.933" "2" "1" "1" "1" "469" "51.7" "7.96" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.934" "0.878" "1.065" "0.995" "0.831" "1.053" "1.000" "0.865" "0.976" "133.3" "124.5" "117.0" "141.9" "132.6" "110.8" "140.4" "133.2" "115.3" "130.0" "" "" "" "" "" "" "" "" "" "" "133.3" "105.3" "74.0" "103.5" "108.6" "86.1" "108.2" "114.5" "90.0" "116.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "High" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.002" "False" "2.931" "4" "1" "1" "1" "203" "23.1" "6.23" "3.40" "1" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "5q35 copy number variation" "Neutrophil degranulation; RAB geranylgeranylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6886594892760411930" "False" "High" "IsMasterProtein" "Q13946" "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A OS=Homo sapiens OX=9606 GN=PDE7A PE=1 SV=2" "0.002" "False" "2.930" "2" "1" "1" "1" "482" "55.5" "7.50" "2.69" "1" "other metabolic processes;signal transduction" "cytosol" "other molecular function" "Pf00233" "5150" "ENSG00000205268" "PDE7A" "A0AVH6; A8K436; A8K9G5; hsa:5150; O15380; Q13946; Q96T72" "Ectoderm differentiation; Ectoderm differentiation; G protein signaling pathways; Phosphodiesterases in neuronal function" "G alpha (s) signalling events" "5" "0" "0.968" "1.164" "1.084" "1.245" "1.058" "1.030" "1.106" "0.967" "0.992" "52.9" "51.2" "61.6" "57.3" "65.9" "56.0" "54.5" "58.5" "51.2" "52.5" "" "" "" "" "" "" "" "" "" "" "52.9" "43.4" "38.9" "41.8" "54.0" "43.5" "42.0" "50.3" "39.9" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.002" "False" "2.927" "2" "1" "1" "1" "384" "43.1" "8.18" "3.83" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2412952300113516382" "False" "High" "IsMasterProtein" "Cont_P28800" "Alpha-2-antiplasmin OS=Bos taurus OX=9913 GN=SERPINF2 PE=1 SV=2" "0.002" "True" "2.919" "2" "1" "1" "1" "492" "54.7" "5.72" "2.51" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "282522" "ENSBIXG00000029361; ENSBTAG00000020859" "SERPINF2" "A0A4W2DRH6; bta:282522; P28800" "Complement and coagulation cascades; Blood clotting cascade" "Platelet degranulation ; Dissolution of Fibrin Clot" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8138947424293882527" "False" "High" "IsMasterProtein" "Q8WV60" "Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD2 PE=1 SV=3" "0.002" "False" "2.919" "3" "1" "1" "1" "388" "43.9" "9.23" "2.31" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion" "" "Pf10037" "79810" "ENSG00000049883" "PTCD2" "B7Z5D0; B7Z8L7; E9PFV7; hsa:79810; Q6IA65; Q8WV60; Q9H9R0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528548452001868396" "False" "High" "IsMasterProtein" "Q8NA72" "Centrosomal protein POC5 OS=Homo sapiens OX=9606 GN=POC5 PE=1 SV=2" "0.002" "False" "2.918" "2" "1" "1" "1" "575" "63.3" "7.42" "2.90" "1" "cell cycle OR cell proliferation" "cytosol;cytoskeleton;nucleus" "" "" "134359" "ENSG00000152359" "POC5" "B4DJG7; hsa:134359; Q494X7; Q494X9; Q6P085; Q8NA72" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3881079650873622249" "False" "High" "IsMasterProtein" "P29466" "Caspase-1 OS=Homo sapiens OX=9606 GN=CASP1 PE=1 SV=1" "0.002" "False" "2.917" "2" "1" "1" "1" "404" "45.1" "5.91" "2.72" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "834" "ENSG00000137752" "CASP1" "B5MDZ1; hsa:834; P29466; Q53EY6; Q6DMQ1; Q6GSS3; Q6PI75; Q9UCN3" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Pleural mesothelioma; Prostaglandin signaling" "TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; NOD1/2 Signaling Pathway; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.002" "False" "2.915" "2" "1" "1" "1" "392" "44.3" "8.65" "3.58" "1" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4949581647878709913" "False" "High" "IsMasterProtein" "Q7Z7A1" "Centriolin OS=Homo sapiens OX=9606 GN=CNTRL PE=1 SV=2" "0.002" "False" "2.914" "0" "1" "1" "1" "2325" "268.7" "5.55" "3.19" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf14580" "11064" "ENSG00000119397" "CNTRL" "A2A2Y1; B2RP67; hsa:11064; Q3MN79; Q5FWF8; Q5JVD0; Q6MZR3; Q6PKC1; Q7Z7A1; Q8TEP3; Q9Y489" "" "Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "High" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.002" "False" "2.913" "3" "1" "1" "1" "238" "26.5" "8.78" "2.92" "1" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6424066842672829369" "False" "High" "IsMasterProtein" "P52952" "Homeobox protein Nkx-2.5 OS=Homo sapiens OX=9606 GN=NKX2-5 PE=1 SV=1" "0.002" "False" "2.906" "3" "1" "1" "1" "324" "34.9" "9.38" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "1482" "ENSG00000183072" "NKX2-5" "A8K3K0; B4DNB6; E9PBU6; hsa:1482; P52952" "Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac progenitor differentiation; 22q11.2 copy number variation syndrome" "Cardiogenesis; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Physiological factors" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1113653796691851863" "False" "High" "IsMasterProtein" "Q86X83" "COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2" "0.002" "False" "2.905" "4" "1" "1" "1" "199" "22.7" "6.73" "2.90" "1" "" "other cell component" "" "Pf07258" "51122" "ENSG00000114744" "COMMD2" "hsa:51122; Q561V4; Q86X83; Q9H3L5; Q9Y5V1" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.002" "False" "2.905" "11" "1" "2" "1" "85" "9.6" "6.00" "4.50" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2108703214608144017" "False" "High" "IsMasterProtein" "Q7Z591" "Microtubule organization protein AKNA OS=Homo sapiens OX=9606 GN=AKNA PE=1 SV=2" "0.002" "False" "2.903" "1" "1" "1" "1" "1439" "155.0" "6.32" "2.78" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12443" "80709" "ENSG00000106948" "AKNA" "hsa:80709; Q05BK5; Q5T535; Q5T536; Q5T537; Q64FX6; Q64FX7; Q64FX8; Q64FY2; Q6ZMK0; Q6ZNL2; Q6ZTX0; Q7Z591; Q8TET1; Q8TF33; Q96RR9; Q9H7P7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.002" "False" "2.899" "7" "1" "1" "1" "107" "11.7" "10.32" "3.50" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "13" "0" "1.032" "1.135" "1.030" "0.991" "1.000" "1.090" "0.855" "1.185" "0.936" "240.4" "248.0" "272.9" "247.6" "238.2" "240.3" "262.1" "205.5" "284.8" "225.1" "" "" "" "" "" "" "" "" "" "" "240.4" "209.8" "172.6" "180.5" "195.2" "186.6" "202.0" "176.7" "222.3" "202.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.002" "False" "2.899" "2" "1" "1" "1" "446" "50.4" "9.63" "1.83" "1" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4933148501745744706" "False" "High" "IsMasterProtein" "O94916" "Nuclear factor of activated T-cells 5 OS=Homo sapiens OX=9606 GN=NFAT5 PE=1 SV=1" "0.002" "False" "2.897" "1" "1" "1" "1" "1531" "165.7" "5.24" "3.35" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "10725" "ENSG00000102908" "NFAT5" "A2RRB4; A6H8V5; E9PHR7; hsa:10725; O94916; O95693; Q7LA65; Q969Q8; Q96QH3; Q9UN18" "Cancer immunotherapy by PD-1 blockade" "" "1" "0" "1.098" "0.774" "1.150" "1.160" "1.039" "1.071" "0.961" "0.816" "0.859" "89.0" "97.7" "68.9" "102.3" "103.2" "92.4" "95.3" "85.5" "72.6" "76.5" "" "" "" "" "" "" "" "" "" "" "89.0" "82.7" "43.5" "74.6" "84.5" "71.8" "73.5" "73.5" "56.7" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2228908930204537618" "False" "High" "IsMasterProtein" "Q7Z4V0" "Zinc finger protein 438 OS=Homo sapiens OX=9606 GN=ZNF438 PE=1 SV=1" "0.002" "False" "2.890" "1" "1" "1" "1" "828" "91.8" "9.39" "2.44" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "220929" "ENSG00000183621" "ZNF438" "A2A3J4; A8K9L5; hsa:220929; Q5T426; Q658Q4; Q6ZN65; Q7Z4V0" "" "" "0" "0" "1.035" "1.028" "1.124" "1.209" "0.804" "1.002" "0.968" "0.825" "0.910" "121.4" "125.6" "124.8" "136.4" "146.8" "97.6" "121.7" "117.5" "100.1" "110.5" "" "" "" "" "" "" "" "" "" "" "121.4" "106.3" "78.9" "99.5" "120.3" "75.8" "93.8" "101.0" "78.2" "99.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8134550695814129755" "False" "High" "IsMasterProtein" "P30519" "Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2" "0.002" "False" "2.888" "3" "1" "1" "1" "316" "36.0" "5.41" "3.52" "1" "other metabolic processes;stress response" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01126" "3163" "ENSG00000103415; ENSG00000277424" "HMOX2" "A8MT35; D3DUD5; hsa:3163; I3L430; O60605; P30519" "" "RHOA GTPase cycle; Neutrophil degranulation; Cytoprotection by HMOX1; Iron uptake and transport; Heme degradation" "5" "0" "0.919" "1.721" "0.961" "0.947" "1.904" "0.960" "0.992" "1.837" "1.325" "113.7" "104.5" "195.6" "109.3" "107.6" "216.5" "109.1" "112.8" "208.8" "150.6" "" "" "" "" "" "" "" "" "" "" "113.7" "88.4" "123.7" "79.7" "88.2" "168.1" "84.1" "97.0" "163.0" "135.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045429465415994492" "False" "High" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "0.002" "False" "2.884" "2" "1" "1" "1" "353" "39.6" "8.37" "2.73" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "" "Mitochondrial protein import" "1" "0" "1.106" "1.533" "1.387" "1.305" "1.408" "1.431" "1.307" "1.548" "1.080" "70.7" "78.2" "108.3" "98.0" "92.2" "99.5" "101.1" "92.4" "109.4" "76.3" "" "" "" "" "" "" "" "" "" "" "70.7" "66.1" "68.5" "71.5" "75.6" "77.3" "78.0" "79.4" "85.4" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4783796531760009514" "False" "High" "IsMasterProtein" "Q9Y228" "TRAF3-interacting JNK-activating modulator OS=Homo sapiens OX=9606 GN=TRAF3IP3 PE=1 SV=2" "0.002" "False" "2.875" "1" "1" "1" "1" "551" "63.6" "8.51" "3.24" "1" "other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "80342" "ENSG00000009790" "TRAF3IP3" "A1L464; A6NIU9; hsa:80342; Q2YDB5; Q4VY06; Q7Z706; Q9Y228" "" "" "0" "0" "0.872" "1.026" "1.075" "0.935" "0.915" "1.096" "1.143" "0.867" "1.072" "94.1" "82.0" "96.5" "101.1" "87.9" "86.1" "103.1" "107.5" "81.5" "100.8" "" "" "" "" "" "" "" "" "" "" "94.1" "69.4" "61.0" "73.7" "72.0" "66.9" "79.5" "92.5" "63.6" "90.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "High" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.002" "False" "2.875" "3" "1" "1" "1" "299" "34.6" "8.91" "3.44" "1" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "Ciliary landscape; Mitochondrial complex III assembly" "" "2" "0" "1.185" "1.010" "1.370" "1.221" "1.095" "1.246" "1.242" "1.012" "1.099" "50.1" "59.4" "50.6" "68.7" "61.2" "54.9" "62.4" "62.3" "50.7" "55.1" "" "" "" "" "" "" "" "" "" "" "50.1" "50.3" "32.0" "50.1" "50.1" "42.6" "48.1" "53.5" "39.6" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6559218798370917350" "False" "High" "IsMasterProtein" "Q6ZUT9" "DENN domain-containing protein 5B OS=Homo sapiens OX=9606 GN=DENND5B PE=1 SV=2" "0.002" "False" "2.874" "1" "1" "1" "1" "1274" "144.9" "6.73" "3.38" "1" "other biological processes" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf01477, Pf02141, Pf02759, Pf03455, Pf03456" "160518" "ENSG00000170456" "DENND5B" "B5ME75; hsa:160518; Q59FW8; Q68CZ7; Q6NUJ0; Q6ZUT9; Q7Z3F9; Q8N973; Q8WUC8" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.966" "0.760" "1.031" "0.859" "1.059" "0.846" "0.882" "0.997" "1.042" "64.2" "62.1" "48.8" "66.2" "55.2" "68.0" "54.3" "56.6" "64.0" "66.9" "" "" "" "" "" "" "" "" "" "" "64.2" "52.5" "30.9" "48.3" "45.2" "52.8" "41.9" "48.7" "49.9" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.002" "False" "2.871" "13" "1" "1" "1" "121" "13.6" "5.08" "2.17" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "HSF1 activation; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "36" "0" "1.209" "2.073" "1.250" "1.521" "1.626" "1.533" "1.820" "2.122" "1.877" "52.0" "62.8" "107.7" "65.0" "79.0" "84.5" "79.7" "94.6" "110.3" "97.5" "" "" "" "" "" "" "" "" "" "" "52.0" "53.1" "68.1" "47.4" "64.8" "65.6" "61.4" "81.3" "86.1" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2919844003918088189" "False" "High" "IsMasterProtein" "Q9P215" "Pogo transposable element with KRAB domain OS=Homo sapiens OX=9606 GN=POGK PE=1 SV=2" "0.002" "False" "2.869" "2" "1" "2" "1" "609" "69.4" "5.14" "4.08" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01352, Pf03184, Pf03221, Pf09607" "57645" "ENSG00000143157" "POGK" "hsa:57645; Q5TIJ1; Q8TE07; Q9P215" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.002" "False" "2.866" "3" "2" "2" "1" "439" "51.9" "4.98" "4.87" "2" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "Canonical and non-canonical Notch signaling; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7587381805021517015" "False" "High" "IsMasterProtein" "Q8IUC6" "TIR domain-containing adapter molecule 1 OS=Homo sapiens OX=9606 GN=TICAM1 PE=1 SV=1" "0.002" "False" "2.861" "1" "1" "1" "1" "712" "76.4" "5.41" "2.95" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf12721, Pf17798" "148022" "ENSG00000127666" "TICAM1" "B3Y691; hsa:148022; O75532; Q86XP8; Q8IUC6; Q96GA0" "Nanoparticle triggered regulated necrosis; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; Toll-like receptor signaling pathway" "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Caspase activation via Death Receptors in the presence of ligand; MyD88-independent TLR4 cascade ; TRIF-mediated programmed cell death; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; RIP-mediated NFkB activation via ZBP1; TICAM1 deficiency - HSE; TRAF3 deficiency - HSE; TLR3-mediated TICAM1-dependent programmed cell death; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.002" "False" "2.857" "2" "1" "1" "1" "427" "47.8" "9.47" "3.39" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "Ub-specific processing proteases; TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Neddylation; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "21" "0" "0.983" "1.064" "1.167" "1.154" "0.977" "0.956" "1.019" "1.190" "1.212" "54.8" "53.9" "58.3" "63.9" "63.2" "53.6" "52.4" "55.8" "65.2" "66.4" "" "" "" "" "" "" "" "" "" "" "54.8" "45.6" "36.9" "46.6" "51.8" "41.6" "40.4" "48.0" "50.9" "59.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.002" "False" "2.856" "1" "1" "1" "1" "1025" "115.7" "8.27" "3.19" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "Metapathway biotransformation Phase I and II" "rRNA modification in the nucleus and cytosol" "2" "0" "1.090" "1.542" "0.802" "1.147" "1.394" "0.960" "1.261" "1.328" "1.244" "44.7" "48.8" "69.0" "35.9" "51.3" "62.4" "43.0" "56.4" "59.4" "55.7" "" "" "" "" "" "" "" "" "" "" "44.7" "41.2" "43.6" "26.1" "42.1" "48.4" "33.1" "48.5" "46.4" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294861354005901566" "False" "High" "IsMasterProtein" "Cont_P17690" "Beta-2-glycoprotein 1 OS=Bos taurus OX=9913 GN=APOH PE=1 SV=4" "0.002" "True" "2.856" "3" "1" "2" "1" "345" "38.2" "8.15" "6.32" "1" "" "non-structural extracellular" "other molecular function" "Pf00084, Pf09014" "281006" "" "APOH" "bta:281006; P17690; Q148G1; Q28052" "" "" "0" "0" "0.938" "0.996" "1.048" "1.016" "1.250" "0.896" "0.834" "1.585" "0.941" "113.6" "106.5" "113.1" "119.0" "115.4" "142.0" "101.7" "94.7" "180.0" "106.9" "" "" "" "" "" "" "" "" "" "" "113.6" "90.1" "71.5" "86.8" "94.6" "110.3" "78.4" "81.4" "140.5" "96.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265573447895357549" "False" "High" "IsMasterProtein" "Q13625" "Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2" "0.002" "False" "2.856" "1" "1" "1" "1" "1128" "125.5" "6.07" "2.53" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00018, Pf00023, Pf21801" "7159" "ENSG00000143514" "TP53BP2" "B4DG66; hsa:7159; Q12892; Q13625; Q86X75; Q96KQ3" "" "TP53 Regulates Transcription of Death Receptors and Ligands; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.002" "False" "2.848" "5" "1" "1" "1" "203" "22.1" "6.55" "3.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2666601626281135846" "False" "High" "IsMasterProtein" "Q92551" "Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3" "0.002" "False" "2.845" "2" "1" "1" "1" "441" "50.2" "7.24" "2.47" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "9807" "ENSG00000176095" "IP6K1" "A8K157; A8MUX4; hsa:9807; Q7L3I7; Q92551; Q96E38" "" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2523415922773781630" "False" "High" "IsMasterProtein" "Q9Y3C1" "Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2" "0.002" "False" "2.844" "4" "1" "1" "1" "178" "21.2" "9.94" "3.04" "1" "other biological processes" "nucleus;other cell component" "" "Pf09420" "51491" "ENSG00000048162" "NOP16" "B4DV13; D6RGD3; hsa:51491; Q05D05; Q6IAI6; Q6PIM0; Q8IXL5; Q9Y3C1" "5q35 copy number variation" "" "1" "0" "0.805" "0.591" "0.742" "0.840" "0.758" "0.784" "0.828" "0.832" "0.859" "129.5" "104.2" "76.5" "96.1" "108.8" "98.2" "101.5" "107.2" "107.7" "111.3" "" "" "" "" "" "" "" "" "" "" "129.5" "88.2" "48.4" "70.0" "89.1" "76.2" "78.2" "92.1" "84.1" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267649899047478727" "False" "High" "IsMasterProtein" "Q92562" "Polyphosphoinositide phosphatase OS=Homo sapiens OX=9606 GN=FIG4 PE=1 SV=1" "0.002" "False" "2.837" "1" "1" "1" "1" "907" "103.6" "6.92" "2.61" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02383" "9896" "ENSG00000112367" "FIG4" "hsa:9896; Q53H49; Q5TCS6; Q92562" "Intracellular trafficking proteins involved in CMT neuropathy" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6992356892802965689" "False" "High" "IsMasterProtein" "Q6UVJ0" "Spindle assembly abnormal protein 6 homolog OS=Homo sapiens OX=9606 GN=SASS6 PE=1 SV=1" "0.002" "False" "2.836" "2" "1" "1" "1" "657" "74.4" "7.55" "2.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf16531, Pf18594" "163786" "ENSG00000156876" "SASS6" "D3DT55; hsa:163786; Q6UVJ0; Q8N3K0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6528342238616596443" "False" "High" "IsMasterProtein" "Q92542" "Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2" "0.002" "False" "2.834" "2" "1" "1" "1" "709" "78.4" "5.99" "2.69" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05450, Pf18266" "23385" "ENSG00000162736" "NCSTN" "hsa:23385; Q5T207; Q5T208; Q86VV5; Q92542" "Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Notch signaling pathway" "Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8268221381324165575" "False" "High" "IsMasterProtein" "Q96B96" "Lipid droplet assembly factor 1 OS=Homo sapiens OX=9606 GN=LDAF1 PE=1 SV=2" "0.002" "False" "2.831" "5" "1" "1" "1" "161" "17.5" "5.06" "3.13" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf16015" "57146" "ENSG00000011638" "LDAF1" "A6NMA9; B4DEC1; hsa:57146; O00323; Q96B96" "" "" "0" "0" "0.954" "1.040" "1.012" "1.042" "0.987" "1.120" "1.040" "0.973" "1.086" "141.2" "134.8" "146.8" "143.0" "147.2" "139.4" "158.2" "146.9" "137.4" "153.3" "" "" "" "" "" "" "" "" "" "" "141.2" "114.0" "92.9" "104.2" "120.6" "108.3" "122.0" "126.3" "107.2" "137.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553626301853439744" "False" "High" "IsMasterProtein" "P63146" "Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1" "0.002" "False" "2.830" "8" "1" "1" "1" "152" "17.3" "5.01" "2.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00179" "7320" "ENSG00000119048" "UBE2B" "B2R503; D3DQA2; hsa:7320; P23567; P63146; Q4PJ15; Q9D0J6" "Proteasome degradation; Male infertility" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Recognition of DNA damage by PCNA-containing replication complex" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8102518268723220557" "False" "High" "IsMasterProtein" "Q2M2I8" "AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3" "0.002" "False" "2.829" "1" "1" "1" "1" "961" "103.8" "6.60" "2.25" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "22848" "ENSG00000115977" "AAK1" "hsa:22848; Q2M2I8; Q4ZFZ3; Q53RX6; Q9UPV4" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.029" "0.937" "0.823" "1.480" "1.433" "0.908" "0.793" "1.169" "0.749" "19.0" "19.6" "17.8" "15.6" "28.1" "27.2" "17.3" "15.1" "22.2" "14.2" "" "" "" "" "" "" "" "" "" "" "19.0" "16.6" "11.3" "11.4" "23.0" "21.1" "13.3" "13.0" "17.3" "12.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5544959501066740394" "False" "High" "IsMasterProtein" "Cont_P02666" "Beta-casein OS=Bos taurus OX=9913 GN=CSN2 PE=1 SV=2" "0.002" "True" "2.821" "8" "1" "1" "1" "224" "25.1" "5.35" "3.95" "1" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00363" "104997418; 109560545; 281099" "" "CSN2" "A0A1U9XAM2; A0A6P3I767; A1YQZ8; A6N8V0; bbis:104997418; biu:109560545; L8I8G5; P02666; Q2TA13; Q5EEQ6; Q5EEQ7; Q6UN63; Q9BDG5; Q9TSD5" "" "" "0" "0" "1.303" "0.826" "1.458" "1.152" "0.839" "1.205" "1.174" "1.033" "1.089" "28.4" "37.1" "23.5" "41.5" "32.8" "23.9" "34.3" "33.4" "29.4" "31.0" "" "" "" "" "" "" "" "" "" "" "28.4" "31.3" "14.9" "30.2" "26.8" "18.5" "26.4" "28.7" "22.9" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444785854763805629" "False" "High" "IsMasterProtein" "O15550" "Lysine-specific demethylase 6A OS=Homo sapiens OX=9606 GN=KDM6A PE=1 SV=2" "0.002" "False" "2.820" "1" "1" "1" "1" "1401" "154.1" "7.44" "1.95" "1" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02373, Pf13181, Pf21322, Pf21326" "7403" "ENSG00000147050" "KDM6A" "hsa:7403; O15550; Q52LL9; Q5JVQ7" "Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones; Chromatin modifications during the maternal to zygotic transition (MZT)" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8001945499400243229" "False" "High" "IsMasterProtein" "Q99519" "Sialidase-1 OS=Homo sapiens OX=9606 GN=NEU1 PE=1 SV=1" "0.002" "False" "2.813" "2" "1" "1" "1" "415" "45.4" "5.88" "2.42" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13088" "4758" "ENSG00000184494; ENSG00000204386; ENSG00000223957; ENSG00000227129; ENSG00000227315; ENSG00000228691; ENSG00000234343; ENSG00000234846" "NEU1" "hsa:4758; Q99519" "" "Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "4" "0" "0.956" "0.964" "1.006" "1.236" "0.864" "1.153" "1.110" "0.866" "1.203" "47.4" "45.3" "45.7" "47.7" "58.6" "40.9" "54.6" "52.6" "41.0" "57.0" "" "" "" "" "" "" "" "" "" "" "47.4" "38.3" "28.9" "34.7" "48.0" "31.8" "42.1" "45.2" "32.0" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.002" "False" "2.800" "8" "1" "1" "1" "106" "12.5" "10.65" "3.48" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.115" "1.423" "1.038" "1.082" "1.559" "1.076" "1.485" "1.624" "1.306" "286.5" "319.5" "407.7" "297.3" "310.0" "446.7" "308.4" "425.4" "465.2" "374.1" "" "" "" "" "" "" "" "" "" "" "286.5" "270.3" "257.8" "216.8" "254.0" "346.9" "237.7" "365.8" "363.1" "336.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084397244840994227" "False" "High" "IsMasterProtein" "Q8N9B5" "Junction-mediating and -regulatory protein OS=Homo sapiens OX=9606 GN=JMY PE=1 SV=2" "0.002" "False" "2.799" "1" "1" "1" "1" "988" "111.4" "6.18" "2.51" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf15871, Pf15920" "133746" "ENSG00000152409" "JMY" "A1L4P5; B5MDS2; B5MDT0; hsa:133746; Q8N9B5" "" "Regulation of TP53 Activity through Methylation" "1" "0" "0.943" "0.811" "1.076" "0.941" "0.825" "1.062" "1.017" "0.979" "1.097" "149.2" "140.7" "121.0" "160.5" "140.4" "123.0" "158.4" "151.6" "146.0" "163.6" "" "" "" "" "" "" "" "" "" "" "149.2" "119.0" "76.5" "117.0" "115.0" "95.5" "122.1" "130.4" "113.9" "147.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4106858905325956782" "False" "High" "IsMasterProtein" "P17483" "Homeobox protein Hox-B4 OS=Homo sapiens OX=9606 GN=HOXB4 PE=1 SV=2" "0.002" "False" "2.793" "5" "1" "1" "1" "251" "27.6" "9.77" "2.49" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3214" "ENSG00000182742" "HOXB4" "hsa:3214; P17483; Q9NTA0" "" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the nephric duct" "2" "0" "1.039" "0.763" "0.939" "1.033" "1.024" "0.934" "0.873" "1.124" "1.130" "29.6" "30.8" "22.6" "27.8" "30.6" "30.3" "27.7" "25.9" "33.3" "33.5" "" "" "" "" "" "" "" "" "" "" "29.6" "26.1" "14.3" "20.3" "25.1" "23.6" "21.3" "22.2" "26.0" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3422303379443285128" "False" "High" "IsMasterProtein" "Q8NBI2" "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 OS=Homo sapiens OX=9606 GN=CYB561A3 PE=1 SV=1" "0.002" "False" "2.792" "4" "1" "1" "1" "242" "27.2" "9.60" "4.16" "1" "transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03188" "220002" "ENSG00000162144" "CYB561A3" "B3KPU2; B4DLN9; hsa:220002; J3KQH4; Q6PK96; Q8NBI2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.002" "False" "2.789" "2" "1" "1" "1" "419" "47.5" "9.16" "3.19" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "28" "0" "1.105" "0.964" "1.093" "1.131" "1.019" "1.384" "1.246" "0.718" "0.998" "88.4" "97.7" "85.2" "96.6" "100.0" "90.1" "122.4" "110.2" "63.4" "88.2" "" "" "" "" "" "" "" "" "" "" "88.4" "82.7" "53.9" "70.5" "81.9" "70.0" "94.4" "94.7" "49.5" "79.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.002" "False" "2.787" "2" "1" "1" "1" "452" "50.8" "5.81" "3.45" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "1.098" "1.209" "0.905" "0.997" "1.085" "1.052" "1.022" "1.104" "1.019" "126.7" "139.1" "153.2" "114.7" "126.3" "137.4" "133.3" "129.5" "139.9" "129.1" "" "" "" "" "" "" "" "" "" "" "126.7" "117.7" "96.8" "83.6" "103.5" "106.7" "102.8" "111.3" "109.2" "116.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.002" "False" "2.786" "4" "1" "1" "1" "218" "21.7" "6.57" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "" "Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; HATs acetylate histones" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926251137078555946" "False" "High" "IsMasterProtein" "Q96IZ5" "RNA-binding protein 41 OS=Homo sapiens OX=9606 GN=RBM41 PE=1 SV=2" "0.003" "False" "2.775" "2" "1" "1" "1" "413" "47.1" "8.70" "2.92" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076" "55285" "ENSG00000089682" "RBM41" "hsa:55285; Q5JSN7; Q5JSN8; Q96IZ5; Q9H8F7; Q9NV04" "" "" "0" "0" "1.054" "0.914" "1.087" "1.211" "0.975" "1.126" "1.223" "0.907" "0.953" "83.9" "88.5" "76.7" "91.2" "101.6" "81.8" "94.5" "102.6" "76.1" "80.0" "" "" "" "" "" "" "" "" "" "" "83.9" "74.8" "48.5" "66.5" "83.2" "63.5" "72.8" "88.3" "59.4" "71.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745274347307830124" "False" "High" "IsMasterProtein" "Q9BX70" "BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1" "0.003" "False" "2.762" "3" "2" "2" "1" "525" "55.9" "5.90" "2.60" "2" "developmental processes" "cytosol;other cell component" "" "Pf00651, Pf07707, Pf08005" "55643" "ENSG00000133243" "BTBD2" "hsa:55643; O60418; O75248; Q4VBZ1; Q6IAC5; Q7Z5W0; Q96SX8; Q9BX70; Q9NPS1; Q9NX81" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260730847028697075" "False" "High" "IsMasterProtein" "Q9BU70" "tRNA (adenine(37)-N6)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMO PE=1 SV=2" "0.003" "False" "2.760" "2" "1" "1" "1" "441" "48.6" "7.17" "2.12" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01980" "51531" "ENSG00000136932" "TRMO" "hsa:51531; Q5T113; Q86SK0; Q9BU70; Q9NXJ7; Q9P0Q7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4117070045163199408" "False" "High" "IsMasterProtein" "Q6NUQ1" "RAD50-interacting protein 1 OS=Homo sapiens OX=9606 GN=RINT1 PE=1 SV=1" "0.003" "False" "2.756" "2" "2" "2" "2" "792" "90.6" "5.45" "5.03" "2" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf04437" "60561" "ENSG00000135249" "RINT1" "hsa:60561; Q6NUQ1; Q75MG9; Q75MH0; Q96IW8; Q9H229; Q9HAD9" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.003" "False" "2.750" "3" "1" "1" "1" "351" "39.5" "4.67" "2.53" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.879" "1.054" "1.179" "1.153" "1.300" "1.256" "1.197" "1.244" "1.199" "72.6" "63.8" "76.5" "85.6" "83.6" "94.3" "91.2" "86.8" "90.2" "87.0" "" "" "" "" "" "" "" "" "" "" "72.6" "54.0" "48.4" "62.4" "68.5" "73.2" "70.3" "74.7" "70.4" "78.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "High" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.003" "False" "2.748" "2" "1" "1" "1" "395" "44.4" "6.76" "2.83" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Dual Incision in GG-NER; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Formation of Incision Complex in GG-NER" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8565728270651974122" "False" "High" "IsMasterProtein" "Q6PCT2" "F-box/LRR-repeat protein 19 OS=Homo sapiens OX=9606 GN=FBXL19 PE=1 SV=3" "0.003" "False" "2.748" "2" "1" "1" "1" "694" "75.7" "9.17" "2.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf16866" "54620" "ENSG00000099364" "FBXL19" "A8MT10; hsa:54620; Q6PCT2; Q8N789; Q9NT14" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "336772770148819757" "False" "High" "IsMasterProtein" "Q9NVR0" "Kelch-like protein 11 OS=Homo sapiens OX=9606 GN=KLHL11 PE=1 SV=1" "0.003" "False" "2.748" "1" "1" "1" "1" "708" "80.1" "6.16" "2.62" "1" "" "cytosol" "" "Pf00651, Pf01344, Pf07707" "55175" "ENSG00000178502" "KLHL11" "hsa:55175; Q9NVR0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286277691384661774" "False" "High" "IsMasterProtein" "Q6P1X5" "Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3" "0.003" "False" "2.741" "1" "1" "1" "1" "1199" "136.9" "8.19" "2.58" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "6873" "ENSG00000064313" "TAF2" "B2RE82; hsa:6873; O43487; O43604; O60668; Q6P1X5; Q86WW7; Q8IWK4" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "1.006" "0.968" "1.338" "1.084" "0.886" "1.088" "1.195" "1.176" "1.052" "34.6" "34.8" "33.5" "46.3" "37.5" "30.6" "37.6" "41.3" "40.7" "36.4" "" "" "" "" "" "" "" "" "" "" "34.6" "29.5" "21.2" "33.7" "30.7" "23.8" "29.0" "35.5" "31.8" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.003" "False" "2.733" "3" "1" "2" "1" "245" "27.6" "7.49" "5.19" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "0.978" "0.968" "1.044" "1.110" "1.072" "1.185" "1.168" "1.008" "1.028" "115.8" "113.2" "112.1" "120.8" "128.5" "124.1" "137.2" "135.2" "116.7" "119.0" "" "" "" "" "" "" "" "" "" "" "115.8" "95.8" "70.9" "88.1" "105.3" "96.4" "105.7" "116.3" "91.1" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6311792634323400615" "False" "High" "IsMasterProtein" "Q9NSU2" "Three-prime repair exonuclease 1 OS=Homo sapiens OX=9606 GN=TREX1 PE=1 SV=2" "0.003" "False" "2.724" "3" "1" "1" "1" "314" "33.2" "7.93" "3.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "11277" "ENSG00000213689" "TREX1" "B2RCN9; hsa:11277; Q8TEU2; Q9BPW1; Q9NSU2; Q9Y4X2" "Cytosolic DNA-sensing pathway" "IRF3-mediated induction of type I IFN; Regulation by TREX1" "3" "0" "1.055" "0.944" "1.171" "1.149" "1.227" "1.197" "1.158" "1.346" "1.209" "60.0" "63.3" "56.6" "70.3" "68.9" "73.6" "71.8" "69.5" "80.7" "72.6" "" "" "" "" "" "" "" "" "" "" "60.0" "53.6" "35.8" "51.2" "56.5" "57.2" "55.4" "59.7" "63.0" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5820747965278093086" "False" "High" "IsMasterProtein" "Q9BPX7" "UPF0415 protein C7orf25 OS=Homo sapiens OX=9606 GN=C7orf25 PE=1 SV=1" "0.003" "False" "2.721" "3" "1" "1" "1" "421" "46.4" "6.42" "3.04" "1" "" "" "" "Pf07000, Pf18474" "79020" "ENSG00000136197" "C7orf25" "A4D1V2; hsa:79020; J3KR36; Q9BPX7; Q9H779" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.003" "False" "2.720" "2" "1" "1" "1" "366" "39.0" "5.08" "3.05" "1" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.003" "False" "2.720" "5" "1" "1" "1" "248" "26.4" "12.23" "2.98" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "0.913" "1.019" "1.033" "1.133" "1.274" "1.097" "1.057" "1.237" "1.138" "63.4" "57.9" "64.6" "65.5" "71.9" "80.8" "69.6" "67.1" "78.5" "72.2" "" "" "" "" "" "" "" "" "" "" "63.4" "49.0" "40.9" "47.8" "58.9" "62.8" "53.6" "57.7" "61.2" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6035111303900286977" "False" "High" "IsMasterProtein" "Q99973" "Telomerase protein component 1 OS=Homo sapiens OX=9606 GN=TEP1 PE=1 SV=2" "0.003" "False" "2.719" "0" "1" "1" "1" "2627" "290.3" "7.97" "3.03" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf05386, Pf05729, Pf05731, Pf13271, Pf19334" "7011" "ENSG00000129566; ENSG00000291791" "TEP1" "A0AUV9; hsa:7011; Q99973" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849777412656735708" "False" "High" "IsMasterProtein" "Q13190" "Syntaxin-5 OS=Homo sapiens OX=9606 GN=STX5 PE=1 SV=2" "0.003" "False" "2.708" "2" "1" "1" "1" "355" "39.6" "9.16" "3.45" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf11416" "6811" "ENSG00000162236" "STX5" "B2R8T2; F8W8Q9; hsa:6811; Q13190; Q5U0D4; Q7Z3T6; Q9BUG1" "Alstrom syndrome" "RHOA GTPase cycle; COPI-mediated anterograde transport; RHOC GTPase cycle; RHOG GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Intra-Golgi traffic; COPII-mediated vesicle transport; Cargo concentration in the ER" "9" "0" "0.976" "0.579" "0.954" "0.826" "0.701" "0.911" "0.882" "0.620" "0.758" "184.0" "179.6" "106.5" "175.6" "151.9" "128.9" "167.6" "162.4" "114.1" "139.4" "" "" "" "" "" "" "" "" "" "" "184.0" "151.9" "67.3" "128.1" "124.5" "100.1" "129.2" "139.6" "89.1" "125.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1613875613327361847" "False" "High" "IsMasterProtein" "Q96G25" "Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2" "0.003" "False" "2.707" "4" "1" "1" "1" "268" "29.1" "7.44" "2.89" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10232" "112950" "ENSG00000159479" "MED8" "A9IZ91; A9IZ92; hsa:112950; Q5JUY8; Q96FQ4; Q96G25" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.003" "False" "2.706" "1" "1" "1" "1" "731" "83.1" "5.24" "3.01" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "High" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.003" "False" "2.704" "1" "1" "1" "1" "837" "95.5" "6.29" "2.84" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441085758956725082" "False" "High" "IsMasterProtein" "P02778" "C-X-C motif chemokine 10 OS=Homo sapiens OX=9606 GN=CXCL10 PE=1 SV=2" "0.003" "False" "2.688" "12" "1" "1" "1" "98" "10.9" "9.86" "2.76" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00048" "3627" "ENSG00000169245" "CXCL10" "hsa:3627; P02778; Q96QJ5" "Spinal cord injury; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Fibrin complement receptor 3 signaling pathway; Hippo-YAP signaling; Hippo-Merlin signaling dysregulation; Interactions between immune cells and microRNAs in tumor microenvironment; Cytosolic DNA-sensing pathway; COVID-19 adverse outcome pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Prostaglandin signaling; Overview of proinflammatory and profibrotic mediators; Lung pathology of COVID-19; Cell interactions of the pancreatic cancer microenvironment; Type II interferon signaling; Toll-like receptor signaling pathway" "G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2643160478096269244" "False" "High" "IsMasterProtein" "O00213" "Amyloid beta precursor protein binding family B member 1 OS=Homo sapiens OX=9606 GN=APBB1 PE=1 SV=2" "0.003" "False" "2.678" "2" "1" "1" "1" "710" "77.2" "5.06" "0.00" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00397, Pf00640" "322" "ENSG00000166313" "APBB1" "A1E379; A6NH82; A6NL69; B7Z1J5; B7Z1J6; B7Z2Y0; D3DQT2; hsa:322; O00213; Q7Z324; Q96A93; V9GYK0; V9GYT4" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8754734411753965302" "False" "High" "IsMasterProtein" "P19823" "Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2" "0.003" "False" "2.676" "1" "1" "1" "1" "946" "106.4" "6.86" "3.20" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00092, Pf06668, Pf08487" "3698" "ENSG00000151655" "ITIH2" "hsa:3698; P19823; Q14659; Q15484; Q5T986" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2999863784191888722" "False" "High" "IsMasterProtein" "Q8TER5" "Rho guanine nucleotide exchange factor 40 OS=Homo sapiens OX=9606 GN=ARHGEF40 PE=1 SV=3" "0.003" "False" "2.672" "1" "1" "1" "1" "1519" "164.6" "6.15" "2.02" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00621" "55701" "ENSG00000165801" "ARHGEF40" "A5PL07; hsa:55701; Q8TER5; Q9BWP5; Q9H7L6; Q9NTF9; Q9NW24" "" "RHOA GTPase cycle; RHOC GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "4" "0" "0.973" "0.990" "0.847" "0.780" "0.899" "0.890" "0.878" "1.029" "1.032" "58.3" "56.8" "57.8" "49.4" "45.5" "52.4" "51.9" "51.2" "60.0" "60.2" "" "" "" "" "" "" "" "" "" "" "58.3" "48.0" "36.5" "36.0" "37.3" "40.7" "40.0" "44.1" "46.9" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2822230476469774963" "False" "High" "IsMasterProtein" "P10415" "Apoptosis regulator Bcl-2 OS=Homo sapiens OX=9606 GN=BCL2 PE=1 SV=2" "0.003" "False" "2.665" "3" "1" "1" "1" "239" "26.2" "7.28" "3.14" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00452, Pf02180" "596" "ENSG00000171791" "BCL2" "C9JHD5; hsa:596; P10415; P10416; Q13842; Q16197" "IL-5 signaling pathway; Influenza A virus infection; TP53 network; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Nanoparticle triggered autophagic cell death; Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Overview of nanoparticle effects; Photodynamic therapy-induced AP-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Acute viral myocarditis; MicroRNA network associated with chronic lymphocytic leukemia; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Hepatitis B infection; Male infertility; Vitamin D-sensitive calcium signaling in depression; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endoplasmic reticulum stress response in coronavirus infection; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; Unfolded protein response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; Clock-controlled autophagy in bone metabolism; Hippocampal synaptogenesis and neurogenesis; TROP2 regulatory signaling; 10q11.21q11.23 copy number variation syndrome; NF1 copy number variation syndrome ; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent); Estrogen signaling pathway" "Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; NFE2L2 regulating tumorigenic genes; Activation of BAD and translocation to mitochondria ; The NLRP1 inflammasome" "59" "0" "1.056" "0.896" "1.012" "1.064" "1.021" "1.006" "1.099" "0.945" "0.914" "295.2" "311.7" "264.3" "298.7" "313.9" "301.5" "297.0" "324.5" "278.8" "269.6" "" "" "" "" "" "" "" "" "" "" "295.2" "263.7" "167.1" "217.8" "257.2" "234.1" "228.9" "279.0" "217.6" "242.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535495802418594220" "False" "High" "IsMasterProtein" "Q9H081" "Protein MIS12 homolog OS=Homo sapiens OX=9606 GN=MIS12 PE=1 SV=1" "0.003" "False" "2.658" "4" "1" "1" "1" "205" "24.1" "5.69" "2.51" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05859" "79003" "ENSG00000167842" "MIS12" "hsa:79003; Q96N24; Q9H081" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "300613952239317335" "False" "High" "IsMasterProtein" "O43766" "Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3" "0.003" "False" "2.652" "3" "1" "1" "1" "372" "41.9" "8.59" "2.94" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion" "other molecular function" "Pf04055, Pf16881" "11019" "ENSG00000121897" "LIAS" "A8K873; C9JCF6; hsa:11019; O43766; Q8IV62" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.003" "False" "2.648" "4" "1" "1" "1" "352" "38.4" "9.11" "3.23" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "8" "0" "0.848" "0.753" "0.853" "0.947" "0.710" "0.796" "0.953" "0.835" "0.961" "68.9" "58.4" "51.9" "58.8" "65.3" "48.9" "54.9" "65.7" "57.5" "66.2" "" "" "" "" "" "" "" "" "" "" "68.9" "49.4" "32.8" "42.9" "53.5" "38.0" "42.3" "56.5" "44.9" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.003" "False" "2.643" "1" "1" "1" "1" "666" "73.1" "5.59" "3.12" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "TYROBP causal network in microglia" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107333921582106986" "False" "High" "IsMasterProtein" "Q9UPR3" "Nonsense-mediated mRNA decay factor SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3" "0.003" "False" "2.633" "1" "1" "2" "1" "1016" "113.9" "5.91" "4.58" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23381" "ENSG00000198952" "SMG5" "D3DVB7; hsa:23381; Q5QJE7; Q659C7; Q8IXC0; Q8IY09; Q96IJ7; Q9UPR3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.003" "False" "2.632" "6" "1" "1" "1" "155" "17.6" "5.67" "3.28" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5352136499893616615" "False" "High" "IsMasterProtein" "O95219" "Sorting nexin-4 OS=Homo sapiens OX=9606 GN=SNX4 PE=1 SV=1" "0.003" "False" "2.619" "2" "1" "1" "1" "450" "51.9" "5.99" "3.29" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787" "8723" "ENSG00000114520" "SNX4" "B3KMH0; B4DQV4; D3DNA3; hsa:8723; O95219" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2836691942658563138" "False" "High" "IsMasterProtein" "Q8TEP8" "Centrosomal protein of 192 kDa OS=Homo sapiens OX=9606 GN=CEP192 PE=1 SV=3" "0.003" "False" "2.618" "1" "2" "2" "2" "2537" "278.9" "5.48" "2.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55125" "ENSG00000101639" "CEP192" "A0A060A9S4; B7ZMF0; E9PF99; hsa:55125; Q8TEP8; Q8WYT8; Q9H0F4; Q9NW27" "Gastric cancer network 1; Genes related to primary cilium development (based on CRISPR); Alstrom syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "10" "0" "1.188" "0.855" "1.343" "1.164" "1.139" "1.275" "1.252" "0.857" "0.887" "23.3" "27.6" "19.9" "31.2" "27.1" "26.5" "29.7" "29.1" "19.9" "20.6" "" "" "" "" "" "" "" "" "" "" "23.3" "23.4" "12.6" "22.8" "22.2" "20.6" "22.9" "25.0" "15.5" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8473500087346521620" "False" "High" "IsMasterProtein" "O43734" "E3 ubiquitin ligase TRAF3IP2 OS=Homo sapiens OX=9606 GN=TRAF3IP2 PE=1 SV=3" "0.003" "False" "2.615" "2" "1" "1" "1" "574" "64.6" "6.76" "2.75" "1" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08357" "10758" "ENSG00000056972" "TRAF3IP2" "B2RAY9; E1P555; hsa:10758; O43734; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72" "IL-17 signaling pathway; VEGFA-VEGFR2 signaling" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.003" "False" "2.611" "9" "1" "1" "1" "99" "11.1" "9.50" "2.44" "1" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3396571255610308931" "False" "High" "IsMasterProtein" "P22692" "Insulin-like growth factor-binding protein 4 OS=Homo sapiens OX=9606 GN=IGFBP4 PE=1 SV=2" "0.003" "False" "2.609" "4" "1" "1" "1" "258" "27.9" "7.15" "2.99" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "non-structural extracellular;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf00219" "3487" "ENSG00000141753" "IGFBP4" "A0N9W2; B4E351; hsa:3487; P22692; Q5U012; Q9UCL6" "Myometrial relaxation and contraction pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.003" "False" "2.608" "6" "1" "1" "1" "127" "14.6" "4.70" "3.11" "1" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "0.913" "0.830" "0.999" "1.207" "0.812" "1.180" "1.070" "0.896" "0.996" "100.4" "91.7" "83.3" "100.3" "121.1" "81.5" "118.4" "107.4" "90.0" "100.0" "" "" "" "" "" "" "" "" "" "" "100.4" "77.6" "52.7" "73.1" "99.3" "63.3" "91.3" "92.4" "70.2" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.004" "False" "2.607" "1" "2" "2" "2" "1224" "136.6" "6.92" "5.80" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "" "RHOH GTPase cycle" "1" "0" "1.096" "1.351" "0.774" "0.923" "0.644" "0.638" "0.656" "0.850" "0.997" "251.4" "275.7" "339.7" "194.5" "232.2" "162.0" "160.4" "164.9" "213.8" "250.8" "" "" "" "" "" "" "" "" "" "" "251.4" "233.2" "214.8" "141.8" "190.2" "125.8" "123.6" "141.8" "166.9" "225.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892501601992705752" "False" "High" "IsMasterProtein" "Q5K651" "Sterile alpha motif domain-containing protein 9 OS=Homo sapiens OX=9606 GN=SAMD9 PE=1 SV=1" "0.004" "False" "2.604" "1" "1" "1" "1" "1589" "184.2" "7.83" "2.75" "1" "cell organization and biogenesis;stress response;transport" "cytosol;other cell component" "" "Pf00536" "54809" "ENSG00000205413" "SAMD9" "A2RU68; hsa:54809; Q5K649; Q5K651; Q6P080; Q75N21; Q8IVG6; Q9NXS8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "High" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.004" "False" "2.603" "1" "1" "6" "1" "691" "73.2" "7.77" "12.52" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "1.064" "1.052" "0.959" "0.955" "0.913" "0.899" "1.018" "1.048" "0.956" "351.1" "373.8" "369.2" "336.6" "335.5" "320.4" "315.5" "357.5" "367.9" "335.5" "" "" "" "" "" "" "" "" "" "" "351.1" "316.2" "233.5" "245.4" "274.9" "248.8" "243.2" "307.4" "287.2" "301.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5363989837697164567" "False" "High" "IsMasterProtein" "Q9Y4C2" "TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3" "0.004" "False" "2.602" "1" "1" "1" "1" "921" "102.1" "6.54" "3.98" "1" "other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13402, Pf17291" "9747" "ENSG00000198420" "TCAF1" "A8K6E0; hsa:9747; Q75KM8; Q75KM9; Q7L665; Q9BW63; Q9Y4C2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.004" "False" "2.596" "5" "1" "1" "1" "185" "21.2" "9.06" "2.77" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.912" "0.885" "0.752" "0.886" "0.970" "1.055" "1.044" "0.784" "0.797" "93.1" "85.0" "82.4" "70.1" "82.6" "90.3" "98.2" "97.3" "73.0" "74.2" "" "" "" "" "" "" "" "" "" "" "93.1" "71.9" "52.1" "51.1" "67.6" "70.1" "75.7" "83.6" "57.0" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.004" "False" "2.594" "1" "1" "1" "1" "743" "83.9" "6.79" "3.03" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "1.288" "1.164" "1.282" "1.301" "1.006" "1.196" "1.486" "1.342" "1.121" "52.9" "68.2" "61.6" "67.9" "68.9" "53.2" "63.3" "78.7" "71.0" "59.3" "" "" "" "" "" "" "" "" "" "" "52.9" "57.7" "38.9" "49.5" "56.4" "41.3" "48.8" "67.6" "55.4" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3436560803263431899" "False" "High" "IsMasterProtein" "P14921" "Protein C-ets-1 OS=Homo sapiens OX=9606 GN=ETS1 PE=1 SV=1" "0.004" "False" "2.594" "2" "1" "1" "1" "441" "50.4" "5.19" "3.11" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf19525" "2113" "ENSG00000134954" "ETS1" "A9UL17; F5GYX9; hsa:2113; P14921; Q14278; Q16080; Q6N087; Q96AC5" "Neural crest differentiation; B cell receptor signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Melanoma; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Oncogene Induced Senescence" "11" "0" "1.033" "0.725" "1.136" "0.935" "0.752" "1.141" "0.940" "0.763" "0.936" "82.3" "85.0" "59.6" "93.5" "76.9" "61.9" "93.9" "77.4" "62.8" "77.1" "" "" "" "" "" "" "" "" "" "" "82.3" "71.9" "37.7" "68.2" "63.0" "48.1" "72.4" "66.5" "49.0" "69.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.004" "False" "2.593" "9" "1" "1" "1" "100" "10.9" "4.27" "3.64" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "0.969" "0.742" "0.906" "1.078" "0.787" "1.017" "0.893" "0.752" "0.939" "161.3" "156.3" "119.7" "146.2" "174.0" "127.0" "164.1" "144.0" "121.3" "151.5" "" "" "" "" "" "" "" "" "" "" "161.3" "132.3" "75.7" "106.6" "142.5" "98.6" "126.5" "123.8" "94.7" "136.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.004" "False" "2.590" "4" "1" "2" "1" "245" "28.3" "8.88" "4.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "ISG15 antiviral mechanism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7929132600900675326" "False" "High" "IsMasterProtein" "Q53GL7" "Protein mono-ADP-ribosyltransferase PARP10 OS=Homo sapiens OX=9606 GN=PARP10 PE=1 SV=2" "0.004" "False" "2.590" "1" "1" "1" "1" "1025" "109.9" "4.97" "3.17" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00644" "84875" "ENSG00000178685" "PARP10" "hsa:84875; Q53GL7; Q8N2I0; Q8WV05; Q96CH7; Q96K72" "" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "3" "0" "1.125" "1.084" "1.147" "1.151" "1.009" "1.015" "1.076" "0.977" "1.151" "163.8" "184.3" "177.7" "187.8" "188.5" "165.3" "166.3" "176.2" "160.0" "188.5" "" "" "" "" "" "" "" "" "" "" "163.8" "156.0" "112.3" "137.0" "154.5" "128.4" "128.2" "151.5" "124.9" "169.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.004" "False" "2.576" "7" "1" "1" "1" "163" "18.8" "7.27" "2.37" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1168885672839203187" "False" "High" "IsMasterProtein" "Q9HC52" "Chromobox protein homolog 8 OS=Homo sapiens OX=9606 GN=CBX8 PE=1 SV=3" "0.004" "False" "2.573" "3" "1" "1" "1" "389" "43.4" "9.91" "2.98" "1" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "57332" "ENSG00000141570" "CBX8" "hsa:57332; Q96H39; Q9HC52; Q9NR07" "" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.004" "False" "2.571" "5" "1" "1" "1" "152" "17.0" "8.31" "3.26" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "0.898" "0.796" "0.954" "0.986" "0.790" "0.880" "0.869" "0.816" "0.929" "217.1" "195.1" "172.9" "207.1" "214.1" "171.5" "191.1" "188.6" "177.2" "201.7" "" "" "" "" "" "" "" "" "" "" "217.1" "165.0" "109.4" "151.0" "175.4" "133.2" "147.3" "162.2" "138.3" "181.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.004" "False" "2.567" "9" "1" "1" "1" "99" "11.2" "4.88" "3.35" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "5" "0" "0.931" "0.896" "0.952" "0.972" "0.936" "1.307" "0.947" "0.943" "1.052" "112.5" "104.7" "100.8" "107.0" "109.3" "105.3" "146.9" "106.5" "106.0" "118.3" "" "" "" "" "" "" "" "" "" "" "112.5" "88.6" "63.7" "78.0" "89.5" "81.7" "113.3" "91.6" "82.8" "106.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2185607745939655049" "False" "High" "IsMasterProtein" "P19532" "Transcription factor E3 OS=Homo sapiens OX=9606 GN=TFE3 PE=1 SV=4" "0.004" "False" "2.560" "2" "2" "2" "2" "575" "61.5" "5.58" "4.90" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7030" "ENSG00000068323; ENSG00000292217" "TFE3" "A8MZL6; hsa:7030; P19532; Q5JU74; Q92757; Q92758; Q99964" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Autophagy in pancreatic ductal adenocarcinoma; TGF-beta receptor signaling" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952210186294942098" "False" "High" "IsMasterProtein" "O15315" "DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2" "0.004" "False" "2.554" "3" "1" "1" "1" "384" "42.2" "5.69" "2.16" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5890" "ENSG00000182185" "RAD51B" "hsa:5890; O15315; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2617055671743182872" "False" "High" "IsMasterProtein" "O75417" "DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2" "0.004" "False" "2.553" "0" "1" "2" "1" "2590" "289.4" "7.36" "4.67" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00476, Pf20470, Pf21099" "10721" "ENSG00000051341" "POLQ" "hsa:10721; O75417; O95160; Q6VMB5" "" "HDR through MMEJ (alt-NHEJ)" "1" "0" "0.752" "0.568" "0.983" "0.570" "0.730" "0.982" "0.960" "0.910" "0.954" "16.6" "12.5" "9.4" "16.3" "9.5" "12.1" "16.3" "15.9" "15.1" "15.8" "" "" "" "" "" "" "" "" "" "" "16.6" "10.6" "6.0" "11.9" "7.7" "9.4" "12.6" "13.7" "11.8" "14.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8879076887959786971" "False" "High" "IsMasterProtein" "Q9P1Y6" "PHD and RING finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PHRF1 PE=1 SV=3" "0.004" "False" "2.552" "0" "1" "1" "1" "1649" "178.6" "8.95" "2.98" "1" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00628, Pf13639" "57661" "ENSG00000070047; ENSG00000274780" "PHRF1" "A6H8W1; B7ZM64; B9EGP0; C9JS82; hsa:57661; Q6PJP2; Q8IVY2; Q8N2Y7; Q9BSM2; Q9P1Y6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.004" "False" "2.552" "2" "1" "1" "1" "483" "54.2" "9.06" "3.34" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.163" "0.974" "1.017" "1.115" "0.789" "1.139" "1.245" "0.896" "0.963" "97.4" "113.3" "94.9" "99.1" "108.6" "76.8" "111.0" "121.3" "87.3" "93.8" "" "" "" "" "" "" "" "" "" "" "97.4" "95.9" "60.0" "72.3" "89.0" "59.7" "85.5" "104.3" "68.2" "84.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696589814023666564" "False" "High" "IsMasterProtein" "Q13503" "Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1" "0.004" "False" "2.549" "8" "1" "1" "1" "144" "15.6" "4.45" "2.58" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11221" "9412" "ENSG00000152944" "MED21" "B2R4I3; hsa:9412; Q13503; Q6IB05; Q92811" "" "RSV-host interactions; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "0" "1.061" "1.116" "1.193" "1.298" "1.262" "0.977" "0.957" "1.041" "1.060" "67.5" "71.6" "75.3" "80.5" "87.6" "85.1" "65.9" "64.6" "70.2" "71.5" "" "" "" "" "" "" "" "" "" "" "67.5" "60.6" "47.6" "58.7" "71.8" "66.1" "50.8" "55.5" "54.8" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "High" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.004" "False" "2.541" "4" "2" "2" "2" "415" "44.3" "9.47" "5.48" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "16" "0" "1.041" "0.910" "1.009" "1.067" "0.948" "1.038" "1.008" "0.953" "1.022" "324.7" "338.0" "295.5" "327.7" "346.3" "307.7" "337.1" "327.3" "309.4" "331.7" "" "" "" "" "" "" "" "" "" "" "324.7" "286.0" "186.9" "239.0" "283.7" "239.0" "259.9" "281.4" "241.5" "298.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2039087024744643374" "False" "High" "IsMasterProtein" "Cont_Q5D862" "Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1" "0.004" "True" "2.526" "3" "1" "1" "1" "2391" "247.9" "8.31" "3.03" "1" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other cell component" "other molecular function" "Pf01023" "388698" "ENSG00000143520" "FLG2" "hsa:388698; Q5D862; Q9H4U1" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.004" "False" "2.526" "10" "1" "1" "1" "175" "19.6" "6.79" "2.12" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2256509221484731544" "False" "High" "IsMasterProtein" "Q8NE18" "Putative methyltransferase NSUN7 OS=Homo sapiens OX=9606 GN=NSUN7 PE=1 SV=4" "0.004" "False" "2.523" "2" "2" "2" "2" "718" "81.0" "8.75" "4.52" "2" "other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01189, Pf21148" "79730" "ENSG00000179299" "NSUN7" "C9JI19; hsa:79730; Q8N9K8; Q8NE18; Q9H815" "" "" "0" "0" "1.086" "1.044" "1.003" "1.234" "1.177" "1.262" "1.293" "1.094" "1.272" "108.2" "117.5" "112.9" "108.4" "133.5" "127.3" "136.5" "139.9" "118.3" "137.6" "" "" "" "" "" "" "" "" "" "" "108.2" "99.4" "71.4" "79.1" "109.4" "98.9" "105.2" "120.3" "92.4" "123.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "High" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.004" "False" "2.521" "4" "1" "1" "1" "366" "39.0" "6.54" "1.80" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "6" "0" "1.001" "1.015" "0.902" "0.948" "1.032" "0.855" "0.950" "1.039" "1.092" "297.0" "297.3" "301.5" "267.9" "281.6" "306.6" "253.9" "282.2" "308.7" "324.3" "" "" "" "" "" "" "" "" "" "" "297.0" "251.5" "190.7" "195.3" "230.7" "238.1" "195.7" "242.7" "241.0" "291.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "High" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.004" "False" "2.520" "0" "1" "1" "1" "2843" "311.5" "7.80" "2.26" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "45" "0" "0.854" "1.417" "1.301" "0.812" "1.125" "1.150" "1.111" "1.119" "1.066" "13.1" "11.2" "18.6" "17.1" "10.7" "14.8" "15.1" "14.6" "14.7" "14.0" "" "" "" "" "" "" "" "" "" "" "13.1" "9.5" "11.8" "12.5" "8.7" "11.5" "11.7" "12.6" "11.5" "12.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6635530035702083019" "False" "High" "IsMasterProtein" "Q68DK2" "Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=4" "0.004" "False" "2.516" "0" "1" "1" "1" "2539" "284.4" "6.39" "2.90" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "23503" "ENSG00000072121" "ZFYVE26" "B1B5Y3; B4E2U3; hsa:23503; O15035; Q68DK2; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; Q96H43" "" "" "0" "0" "0.999" "0.940" "1.019" "1.088" "0.833" "1.022" "1.068" "0.972" "0.868" "63.1" "63.0" "59.3" "64.3" "68.6" "52.6" "64.5" "67.4" "61.3" "54.7" "" "" "" "" "" "" "" "" "" "" "63.1" "53.3" "37.5" "46.9" "56.2" "40.8" "49.7" "57.9" "47.9" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "High" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.004" "False" "2.514" "2" "1" "1" "1" "491" "54.5" "8.29" "2.58" "1" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "" "InlA-mediated entry of Listeria monocytogenes into host cells" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3248682762130005719" "False" "High" "IsMasterProtein" "Q9BQ39" "ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1" "0.004" "False" "2.508" "1" "1" "1" "1" "737" "82.5" "9.17" "2.49" "1" "" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00270, Pf00271, Pf08152" "79009" "ENSG00000107625" "DDX50" "hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4509780979578999144" "False" "High" "IsMasterProtein" "Q8WUX1" "Sodium-coupled neutral amino acid transporter 5 OS=Homo sapiens OX=9606 GN=SLC38A5 PE=1 SV=1" "0.004" "False" "2.507" "2" "1" "1" "1" "472" "51.4" "8.21" "2.93" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf01490" "92745" "ENSG00000017483" "SLC38A5" "B3KT20; B5MDE6; B7WPJ9; hsa:92745; Q6PIW9; Q8WUX1; Q8WYU2; Q96PQ4" "Neuroinflammation and glutamatergic signaling" "Amino acid transport across the plasma membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3008882847524475916" "False" "High" "IsMasterProtein" "Q15041" "ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Homo sapiens OX=9606 GN=ARL6IP1 PE=1 SV=2" "0.004" "False" "2.506" "4" "1" "1" "1" "203" "23.3" "9.32" "3.28" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "" "23204" "ENSG00000170540" "ARL6IP1" "B7Z6S5; B7Z791; F5GXP4; hsa:23204; Q15041" "" "" "0" "0" "0.980" "0.868" "0.928" "0.977" "0.866" "0.986" "1.037" "0.797" "0.878" "211.2" "207.0" "183.4" "196.0" "206.4" "182.8" "208.3" "219.1" "168.3" "185.3" "" "" "" "" "" "" "" "" "" "" "211.2" "175.1" "116.0" "142.9" "169.1" "142.0" "160.6" "188.3" "131.4" "166.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5305151798806457032" "False" "High" "IsMasterProtein" "Q9UJ68" "Mitochondrial peptide methionine sulfoxide reductase OS=Homo sapiens OX=9606 GN=MSRA PE=1 SV=1" "0.004" "False" "2.505" "3" "1" "1" "1" "235" "26.1" "8.09" "2.06" "1" "protein metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01625" "4482" "ENSG00000175806; ENSG00000285250" "MSRA" "E9PAS8; hsa:4482; Q52TC4; Q549N4; Q66MI7; Q9UJ68" "Sulindac metabolic pathway; Methionine de novo and salvage pathway; 8p23.1 copy number variation syndrome" "Protein repair" "4" "0" "0.465" "1.256" "0.722" "0.652" "0.927" "0.719" "0.480" "0.725" "0.670" "17.4" "8.1" "21.9" "12.6" "11.4" "16.2" "12.5" "8.4" "12.6" "11.7" "" "" "" "" "" "" "" "" "" "" "17.4" "6.9" "13.8" "9.2" "9.3" "12.6" "9.7" "7.2" "9.9" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.004" "False" "2.500" "1" "1" "1" "1" "578" "65.5" "8.21" "2.83" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "" "Mitochondrial tRNA aminoacylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.004" "False" "2.495" "4" "1" "2" "1" "186" "21.0" "6.20" "4.55" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "0.927" "1.262" "1.102" "1.030" "1.146" "0.911" "0.880" "1.213" "0.977" "49.2" "45.6" "62.1" "54.3" "50.7" "56.4" "44.9" "43.3" "59.7" "48.1" "" "" "" "" "" "" "" "" "" "" "49.2" "38.6" "39.3" "39.6" "41.5" "43.8" "34.6" "37.2" "46.6" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466607120088991796" "False" "High" "IsMasterProtein" "P51888" "Prolargin OS=Homo sapiens OX=9606 GN=PRELP PE=1 SV=1" "0.004" "False" "2.491" "3" "1" "1" "1" "382" "43.8" "9.38" "2.53" "1" "other metabolic processes;stress response;developmental processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cytoplasmic organelle" "extracellular structural activity;other molecular function" "Pf13855" "5549" "ENSG00000188783" "PRELP" "hsa:5549; P51888; Q6FG38" "" "Keratan sulfate biosynthesis; Keratan sulfate degradation; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)" "5" "0" "1.292" "0.899" "0.876" "1.078" "1.089" "1.047" "1.037" "0.977" "1.021" "161.6" "208.7" "145.3" "141.5" "174.1" "175.9" "169.1" "167.5" "157.8" "165.0" "" "" "" "" "" "" "" "" "" "" "161.6" "176.6" "91.9" "103.2" "142.7" "136.6" "130.4" "144.0" "123.2" "148.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.004" "False" "2.480" "4" "1" "1" "1" "235" "25.2" "7.59" "3.23" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.004" "False" "2.479" "11" "1" "2" "1" "63" "6.9" "7.24" "5.40" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "Mitochondrial protein import" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.004" "False" "2.478" "1" "1" "1" "1" "696" "81.8" "4.77" "3.19" "1" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "" "Intra-Golgi traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7170816328475154252" "False" "High" "IsMasterProtein" "Cont_Q2KJF1" "Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1" "0.004" "True" "2.473" "3" "1" "1" "1" "503" "53.5" "5.43" "2.50" "1" "" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00047" "518955" "ENSBTAG00000009735" "A1BG" "bta:518955; Q2KJF1" "" "Neutrophil degranulation; Platelet degranulation" "2" "0" "1.000" "0.805" "1.139" "0.836" "0.954" "0.840" "0.641" "1.364" "0.878" "29.0" "29.0" "23.4" "33.0" "24.3" "27.7" "24.4" "18.6" "39.6" "25.5" "" "" "" "" "" "" "" "" "" "" "29.0" "24.5" "14.8" "24.1" "19.9" "21.5" "18.8" "16.0" "30.9" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8780259354878837006" "False" "High" "IsMasterProtein" "Q7Z7L7" "Protein zer-1 homolog OS=Homo sapiens OX=9606 GN=ZER1 PE=1 SV=1" "0.004" "False" "2.472" "2" "1" "1" "1" "766" "88.1" "5.62" "1.65" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "10444" "ENSG00000160445" "ZER1" "hsa:10444; O00156; Q5T272; Q5T273; Q7Z7L7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155133754937223753" "False" "High" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "0.004" "False" "2.463" "5" "1" "1" "1" "210" "23.8" "6.40" "2.74" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "549572925276105069" "False" "High" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "0.004" "False" "2.463" "1" "1" "1" "1" "1271" "142.7" "7.03" "2.83" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541658205894384730" "False" "High" "IsMasterProtein" "Q8N8R7" "ARL14 effector protein OS=Homo sapiens OX=9606 GN=ARL14EP PE=1 SV=1" "0.004" "False" "2.455" "3" "1" "1" "1" "260" "29.3" "8.07" "3.40" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf14949" "120534" "ENSG00000152219" "ARL14EP" "hsa:120534; Q5HYH9; Q8N8R7" "" "" "0" "0" "1.069" "0.883" "1.150" "1.178" "1.000" "1.295" "1.163" "0.816" "1.217" "116.7" "124.7" "103.0" "134.2" "137.4" "116.6" "151.1" "135.7" "95.3" "142.0" "" "" "" "" "" "" "" "" "" "" "116.7" "105.5" "65.1" "97.9" "112.6" "90.6" "116.5" "116.7" "74.3" "127.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.004" "False" "2.453" "1" "1" "1" "1" "808" "87.1" "9.19" "2.85" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.004" "False" "2.448" "1" "1" "1" "1" "846" "94.8" "8.78" "2.98" "1" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.004" "False" "2.444" "2" "1" "1" "1" "430" "47.1" "4.49" "3.74" "1" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "0.963" "0.924" "1.124" "1.025" "1.016" "1.121" "0.937" "0.985" "0.935" "168.6" "162.3" "155.8" "189.5" "172.7" "171.2" "188.9" "157.9" "166.0" "157.7" "" "" "" "" "" "" "" "" "" "" "168.6" "137.3" "98.5" "138.1" "141.5" "132.9" "145.6" "135.7" "129.6" "141.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.004" "False" "2.442" "4" "1" "1" "1" "293" "32.6" "9.88" "2.63" "1" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105590479105363220" "False" "High" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "0.004" "False" "2.440" "3" "1" "1" "1" "393" "45.3" "8.95" "2.82" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2600718552513118007" "False" "High" "IsMasterProtein" "Q86VR2" "Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1" "0.004" "False" "2.439" "2" "1" "1" "1" "466" "51.4" "4.97" "2.85" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "" "162427" "ENSG00000141699" "RETREG3" "B3KR75; hsa:162427; Q86VR2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1153318479582770530" "False" "High" "IsMasterProtein" "P53677" "AP-3 complex subunit mu-2 OS=Homo sapiens OX=9606 GN=AP3M2 PE=1 SV=1" "0.004" "False" "2.439" "2" "1" "1" "1" "418" "46.9" "7.56" "3.20" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf00928, Pf01217" "10947" "ENSG00000070718" "AP3M2" "B2RCR0; D3DSY2; hsa:10947; P53677; Q7Z472" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3090856641429635389" "False" "High" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN2 PE=1 SV=1" "0.005" "False" "2.436" "6" "1" "1" "1" "294" "31.8" "6.55" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003, Pf20635, Pf20636" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.008" "0.989" "0.996" "1.301" "0.908" "1.119" "1.113" "0.924" "0.993" "32.1" "32.3" "31.7" "31.9" "41.7" "29.1" "35.9" "35.7" "29.6" "31.8" "" "" "" "" "" "" "" "" "" "" "32.1" "27.3" "20.1" "23.3" "34.2" "22.6" "27.7" "30.7" "23.1" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3525120211935772800" "False" "High" "IsMasterProtein" "Q9H892" "Tetratricopeptide repeat protein 12 OS=Homo sapiens OX=9606 GN=TTC12 PE=1 SV=2" "0.005" "False" "2.435" "1" "1" "2" "1" "705" "78.7" "5.66" "2.98" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf00515, Pf13181" "54970" "ENSG00000149292" "TTC12" "hsa:54970; Q8N5H9; Q9H892; Q9NWY3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.005" "False" "2.419" "2" "1" "1" "1" "344" "39.4" "7.68" "2.61" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "Primary ovarian insufficiency" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.005" "False" "2.413" "2" "1" "1" "1" "615" "70.5" "5.96" "2.73" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "1.178" "0.849" "1.003" "1.470" "1.148" "1.373" "1.209" "0.955" "1.454" "23.6" "27.8" "20.0" "23.7" "34.7" "27.1" "32.4" "28.5" "22.5" "34.3" "" "" "" "" "" "" "" "" "" "" "23.6" "23.5" "12.7" "17.2" "28.4" "21.0" "25.0" "24.5" "17.6" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.005" "False" "2.403" "3" "1" "1" "1" "203" "23.8" "9.26" "3.38" "1" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "0.853" "0.885" "0.883" "0.930" "0.935" "0.895" "0.835" "0.739" "0.836" "178.8" "152.6" "158.2" "157.8" "166.3" "167.2" "160.0" "149.2" "132.1" "149.4" "" "" "" "" "" "" "" "" "" "" "178.8" "129.1" "100.0" "115.1" "136.2" "129.8" "123.3" "128.3" "103.1" "134.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3275196182656961977" "False" "High" "IsMasterProtein" "Q8WXB1" "Protein N-lysine methyltransferase METTL21A OS=Homo sapiens OX=9606 GN=METTL21A PE=1 SV=2" "0.005" "False" "2.401" "3" "1" "1" "1" "218" "24.6" "6.27" "2.48" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "151194" "ENSG00000144401" "METTL21A" "hsa:151194; Q53RV0; Q8N1Z9; Q8WXB1; Q96GH6" "" "Protein methylation" "1" "0" "1.163" "1.124" "1.249" "0.999" "1.318" "1.187" "1.077" "1.049" "1.341" "46.9" "54.5" "52.7" "58.5" "46.8" "61.7" "55.6" "50.5" "49.2" "62.8" "" "" "" "" "" "" "" "" "" "" "46.9" "46.1" "33.3" "42.7" "38.4" "47.9" "42.9" "43.4" "38.4" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028441251658952013" "False" "High" "IsMasterProtein" "Q9H7L9" "Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2" "0.005" "False" "2.395" "2" "1" "1" "1" "328" "38.1" "5.66" "2.96" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08598" "64426" "ENSG00000111707" "SUDS3" "hsa:64426; Q4KMQ5; Q8N6H0; Q9H7L9; Q9H8D2" "" "Ub-specific processing proteases; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Potential therapeutics for SARS" "4" "0" "1.048" "0.903" "1.204" "1.201" "1.075" "1.072" "0.913" "0.876" "1.017" "82.0" "85.9" "74.0" "98.7" "98.5" "88.2" "87.9" "74.9" "71.8" "83.4" "" "" "" "" "" "" "" "" "" "" "82.0" "72.7" "46.8" "72.0" "80.7" "68.5" "67.8" "64.4" "56.0" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.005" "False" "2.393" "1" "1" "1" "1" "689" "78.7" "6.60" "2.73" "1" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4731047404195791293" "False" "High" "IsMasterProtein" "Q8IXW5" "Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 OS=Homo sapiens OX=9606 GN=RPAP2 PE=1 SV=1" "0.005" "False" "2.390" "1" "1" "1" "1" "612" "69.5" "7.78" "2.43" "1" "RNA metabolism OR transcription;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04181" "79871" "ENSG00000122484" "RPAP2" "C9JKB5; hsa:79871; Q49AS7; Q8IXW5; Q9H8Y2" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.971" "0.698" "0.911" "0.999" "0.796" "0.883" "0.951" "0.790" "0.821" "113.2" "109.9" "79.1" "103.1" "113.1" "90.2" "100.0" "107.7" "89.5" "92.9" "" "" "" "" "" "" "" "" "" "" "113.2" "93.0" "50.0" "75.2" "92.6" "70.0" "77.1" "92.6" "69.8" "83.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.005" "False" "2.376" "2" "1" "1" "1" "448" "47.3" "5.88" "2.42" "1" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7144530855907264984" "False" "High" "IsMasterProtein" "Q9H6R4" "Nucleolar protein 6 OS=Homo sapiens OX=9606 GN=NOL6 PE=1 SV=2" "0.005" "False" "2.362" "1" "1" "1" "1" "1146" "127.5" "7.64" "2.36" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf03813, Pf17403, Pf17404, Pf17405, Pf17406, Pf17407" "65083" "ENSG00000165271" "NOL6" "hsa:65083; Q5T5M3; Q5T5M4; Q7L4G6; Q8N6I0; Q8TEY9; Q8TEZ0; Q8TEZ1; Q9H675; Q9H6R4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.136" "1.436" "1.120" "1.161" "1.560" "1.113" "1.095" "1.211" "1.253" "27.4" "31.2" "39.4" "30.7" "31.8" "42.8" "30.5" "30.0" "33.2" "34.4" "" "" "" "" "" "" "" "" "" "" "27.4" "26.4" "24.9" "22.4" "26.1" "33.2" "23.5" "25.8" "25.9" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8412715806264131259" "False" "High" "IsMasterProtein" "Q5F1R6" "DnaJ homolog subfamily C member 21 OS=Homo sapiens OX=9606 GN=DNAJC21 PE=1 SV=2" "0.005" "False" "2.360" "2" "1" "1" "1" "531" "62.0" "5.47" "2.72" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00226, Pf12171" "134218" "ENSG00000168724" "DNAJC21" "Q3B7J9; Q5F1R6; Q6P086; Q6ZS43; Q86VC6" "" "" "0" "0" "1.060" "1.178" "0.895" "0.932" "1.499" "0.899" "1.013" "1.301" "1.158" "101.5" "107.7" "119.6" "90.9" "94.7" "152.2" "91.3" "102.9" "132.1" "117.6" "" "" "" "" "" "" "" "" "" "" "101.5" "91.1" "75.6" "66.3" "77.6" "118.2" "70.3" "88.4" "103.1" "105.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3777783708088155115" "False" "High" "IsMasterProtein" "Q96AP0" "Adrenocortical dysplasia protein homolog OS=Homo sapiens OX=9606 GN=ACD PE=1 SV=4" "0.005" "False" "2.357" "2" "1" "1" "1" "458" "48.9" "5.30" "2.31" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10341" "65057" "ENSG00000102977" "ACD" "A0A0C4DGT6; hsa:65057; Q562H5; Q96AP0; Q9H8F9" "" "Polymerase switching on the C-strand of the telomere; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "14" "0" "0.896" "0.669" "0.923" "0.889" "0.642" "0.894" "0.925" "0.978" "0.788" "31.9" "28.6" "21.3" "29.4" "28.3" "20.5" "28.5" "29.5" "31.2" "25.1" "" "" "" "" "" "" "" "" "" "" "31.9" "24.2" "13.5" "21.5" "23.2" "15.9" "22.0" "25.4" "24.4" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1241863298076822509" "False" "High" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "0.005" "False" "2.355" "0" "1" "1" "1" "2279" "251.0" "7.20" "2.20" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "Androgen receptor signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8594684179756660612" "False" "High" "IsMasterProtein" "O77932" "Decapping and exoribonuclease protein OS=Homo sapiens OX=9606 GN=DXO PE=1 SV=2" "0.005" "False" "2.353" "2" "1" "1" "1" "396" "44.9" "7.69" "2.40" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf08652" "1797" "ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765" "DXO" "A2CER3; B0UZ80; hsa:1797; O15004; O77932; O78127; O78128; Q5ST60; Q6IPZ2; Q9NPK4" "" "" "0" "0" "1.088" "0.862" "0.992" "1.049" "0.917" "0.704" "0.913" "1.106" "1.037" "47.3" "51.5" "40.8" "46.9" "49.7" "43.4" "33.3" "43.2" "52.4" "49.1" "" "" "" "" "" "" "" "" "" "" "47.3" "43.6" "25.8" "34.2" "40.7" "33.7" "25.7" "37.1" "40.9" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.005" "False" "2.350" "4" "2" "2" "2" "350" "39.1" "8.22" "2.68" "2" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394219767961209764" "False" "High" "IsMasterProtein" "Q5T5Y3" "Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2" "0.005" "False" "2.347" "1" "1" "1" "1" "1602" "177.9" "6.73" "3.08" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "157922" "ENSG00000130559" "CAMSAP1" "A1L4L2; B2REB2; B2REB3; hsa:157922; Q5T5Y3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7630031287778180300" "False" "High" "IsMasterProtein" "O75081" "Protein CBFA2T3 OS=Homo sapiens OX=9606 GN=CBFA2T3 PE=1 SV=2" "0.005" "False" "2.345" "1" "1" "1" "1" "653" "71.1" "8.18" "2.16" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf01753, Pf07531, Pf08788" "863" "ENSG00000129993" "CBFA2T3" "D3DX78; hsa:863; O60615; O60616; O60617; O75081; O75082; O75107; O75108; Q0P5Z6; Q6P5W6" "Hematopoietic stem cell differentiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6091940501454683011" "False" "High" "IsMasterProtein" "Q9UNX4" "WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1" "0.005" "False" "2.342" "1" "1" "1" "1" "943" "106.0" "6.64" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf04003, Pf12894" "10885" "ENSG00000065183" "WDR3" "hsa:10885; Q9UNX4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7548754380540719877" "False" "High" "IsMasterProtein" "Q96ET8" "Golgi apparatus membrane protein TVP23 homolog C OS=Homo sapiens OX=9606 GN=TVP23C PE=1 SV=3" "0.005" "False" "2.341" "3" "1" "1" "1" "276" "31.1" "9.29" "2.96" "1" "transport" "other membranes" "" "Pf05832" "100533496; 201158" "ENSG00000175106" "TVP23C" "hsa:100533496; hsa:201158; Q3LIC7; Q96ET8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058994257240808720" "False" "High" "IsMasterProtein" "Q9ULR5" "Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2" "0.005" "False" "2.338" "7" "1" "1" "1" "123" "14.2" "4.17" "3.03" "1" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "400961" "ENSG00000124374" "PAIP2B" "hsa:400961; Q9ULR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "High" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.005" "False" "2.336" "4" "1" "1" "1" "209" "23.7" "6.68" "2.40" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4105769586193157402" "False" "High" "IsMasterProtein" "Q02410" "Amyloid-beta A4 precursor protein-binding family A member 1 OS=Homo sapiens OX=9606 GN=APBA1 PE=1 SV=3" "0.005" "False" "2.335" "1" "1" "1" "1" "837" "92.8" "4.93" "2.61" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00595, Pf00640" "320" "ENSG00000107282" "APBA1" "hsa:320; O14914; O60570; Q02410; Q5VYR8" "" "Neurexins and neuroligins; Assembly and cell surface presentation of NMDA receptors; Dopamine Neurotransmitter Release Cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "451284985450217438" "False" "High" "IsMasterProtein" "Q9NVV4" "Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP PE=1 SV=1" "0.005" "False" "2.330" "1" "1" "1" "1" "582" "66.1" "9.04" "3.68" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03828, Pf17797" "55149" "ENSG00000107951" "MTPAP" "D3DRX0; hsa:55149; Q659E3; Q6P7E5; Q9HA74; Q9NVV4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330656270512848682" "False" "High" "IsMasterProtein" "Q8WVR3" "Trafficking protein particle complex subunit 14 OS=Homo sapiens OX=9606 GN=TRAPPC14 PE=1 SV=2" "0.005" "False" "2.329" "3" "1" "1" "1" "580" "62.6" "8.87" "2.35" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf15806" "55262" "ENSG00000146826" "TRAPPC14" "A4D2A9; D6W5U4; hsa:55262; Q8WVR3; Q9BQJ1; Q9BUB6; Q9NV47" "" "" "0" "0" "0.960" "0.802" "0.900" "1.114" "1.423" "0.854" "0.704" "0.729" "1.035" "28.9" "27.8" "23.2" "26.0" "32.2" "41.2" "24.7" "20.4" "21.1" "30.0" "" "" "" "" "" "" "" "" "" "" "28.9" "23.5" "14.7" "19.0" "26.4" "32.0" "19.0" "17.5" "16.5" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "High" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.005" "False" "2.328" "6" "1" "1" "1" "148" "16.5" "9.16" "2.75" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Macrophage markers; Pancreatic cancer subtypes" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "High" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.005" "False" "2.327" "3" "1" "1" "1" "208" "23.3" "5.69" "3.07" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "33" "0" "1.228" "0.868" "1.228" "1.307" "0.948" "1.168" "1.161" "0.881" "1.025" "61.4" "75.4" "53.3" "75.4" "80.3" "58.2" "71.7" "71.3" "54.1" "63.0" "" "" "" "" "" "" "" "" "" "" "61.4" "63.8" "33.7" "55.0" "65.8" "45.2" "55.3" "61.3" "42.2" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2350188829608931465" "False" "High" "IsMasterProtein" "Q8TDD1" "ATP-dependent RNA helicase DDX54 OS=Homo sapiens OX=9606 GN=DDX54 PE=1 SV=2" "0.005" "False" "2.327" "1" "1" "1" "1" "881" "98.5" "10.02" "3.24" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00270, Pf00271, Pf08147" "79039" "ENSG00000123064" "DDX54" "hsa:79039; Q86YT8; Q8TDD1; Q9BRZ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888778230352659976" "False" "High" "IsMasterProtein" "O14908" "PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2" "0.005" "False" "2.326" "4" "1" "1" "1" "333" "36.0" "6.28" "2.52" "1" "cell-cell signaling;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00595" "10755" "ENSG00000123159" "GIPC1" "A8K4I3; A8MZG3; hsa:10755; O14908; Q9BTC9" "VEGFA-VEGFR2 signaling" "FGFR1b ligand binding and activation; FGFR1c ligand binding and activation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7218272349989461582" "False" "High" "IsMasterProtein" "Q9H211" "DNA replication factor Cdt1 OS=Homo sapiens OX=9606 GN=CDT1 PE=1 SV=3" "0.005" "False" "2.326" "2" "1" "1" "1" "546" "60.4" "9.77" "2.45" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08839, Pf16679" "81620" "ENSG00000167513" "CDT1" "hsa:81620; Q86XX9; Q96CJ5; Q96GK5; Q96H67; Q96HE6; Q9BWM0; Q9H211" "Retinoblastoma gene in cancer; DNA replication" "Assembly of the pre-replicative complex; Orc1 removal from chromatin; Activation of the pre-replicative complex; G1/S-Specific Transcription" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2021793089049175464" "False" "High" "IsMasterProtein" "Q9HD67" "Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3" "0.005" "False" "2.325" "0" "1" "1" "1" "2058" "237.2" "6.21" "2.92" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00169, Pf00373, Pf00612, Pf00784, Pf00788, Pf16735, Pf18597" "4651" "ENSG00000145555" "MYO10" "A7E2D1; hsa:4651; O94893; Q8IVX5; Q9HD67; Q9NYM7; Q9P110; Q9P111; Q9UHF6" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.005" "False" "2.324" "2" "1" "1" "1" "312" "34.8" "8.37" "3.17" "1" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104701307196402264" "False" "High" "IsMasterProtein" "Q96PE3" "Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1" "0.005" "False" "2.322" "1" "1" "2" "1" "977" "109.9" "6.96" "2.16" "1" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "3631" "ENSG00000040933" "INPP4A" "hsa:3631; O15326; Q13187; Q53TD8; Q8TC02; Q96PE3" "Insulin signaling" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "190648059904117416" "False" "High" "IsMasterProtein" "Q9UQ90" "Mitochondrial inner membrane m-AAA protease component paraplegin OS=Homo sapiens OX=9606 GN=SPG7 PE=1 SV=2" "0.005" "False" "2.321" "2" "1" "2" "1" "795" "88.2" "8.69" "1.63" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "6687" "ENSG00000197912" "SPG7" "hsa:6687; O75756; Q2TB70; Q58F00; Q96IB0; Q9UQ90" "" "Mitochondrial protein degradation; Processing of SMDT1" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5819226307907089360" "False" "High" "IsMasterProtein" "Q99996" "A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9 PE=1 SV=4" "0.005" "False" "2.318" "0" "1" "1" "1" "3907" "452.7" "4.98" "2.39" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10495" "10142" "ENSG00000127914" "AKAP9" "A4D1F0; A4D1F2; A4D1F4; hsa:10142; O14869; O43355; O94895; Q75N20; Q99996; Q9UQH3; Q9UQQ4; Q9Y6B8; Q9Y6Y2" "G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection" "Signaling by BRAF and RAF1 fusions; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Phase 3 - rapid repolarisation; Phase 2 - plateau phase" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.005" "False" "2.317" "8" "1" "1" "1" "102" "11.2" "9.32" "2.52" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3972867758103870648" "False" "High" "IsMasterProtein" "P49619" "Diacylglycerol kinase gamma OS=Homo sapiens OX=9606 GN=DGKG PE=1 SV=3" "0.005" "False" "2.317" "2" "1" "2" "1" "791" "89.1" "6.80" "2.52" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00130, Pf00609, Pf00781, Pf14513" "1608" "ENSG00000058866" "DGKG" "B2RAH4; hsa:1608; P49619; Q2M1H4; Q5FWG1" "" "Effects of PIP2 hydrolysis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2978485946285835937" "False" "High" "IsMasterProtein" "Q8NHH9" "Atlastin-2 OS=Homo sapiens OX=9606 GN=ATL2 PE=1 SV=2" "0.005" "False" "2.312" "1" "1" "1" "1" "583" "66.2" "5.48" "2.11" "1" "cell organization and biogenesis" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "64225" "ENSG00000119787" "ATL2" "B7Z1X2; B7Z7X8; hsa:64225; Q4ZG30; Q7Z630; Q8NHH8; Q8NHH9; Q9H5M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.005" "False" "2.305" "2" "1" "1" "1" "476" "54.7" "9.03" "2.15" "1" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.005" "False" "2.302" "9" "1" "1" "1" "89" "10.4" "7.21" "1.96" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "" "Mitochondrial protein import; Mitochondrial protein degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8081850607027736323" "False" "High" "IsMasterProtein" "Q9P0J1" "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDP1 PE=1 SV=3" "0.005" "False" "2.297" "2" "1" "1" "1" "537" "61.0" "6.67" "2.36" "1" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "54704" "ENSG00000164951" "PDP1" "B3KX71; hsa:54704; J3KPU0; Q5U5K1; Q9P0J1" "Orexin receptor pathway; Glucose metabolism in triple-negative breast cancer cells" "Regulation of pyruvate dehydrogenase (PDH) complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8813199514956100081" "False" "High" "IsMasterProtein" "O94822" "E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6" "0.005" "False" "2.289" "1" "1" "2" "1" "1766" "200.4" "6.25" "4.53" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "" "26046" "ENSG00000198862; ENSG00000291534" "LTN1" "A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; O94822; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309622094588707554" "False" "High" "IsMasterProtein" "Q9UHK0" "FMR1-interacting protein NUFIP1 OS=Homo sapiens OX=9606 GN=NUFIP1 PE=1 SV=2" "0.005" "False" "2.288" "2" "1" "1" "1" "495" "56.3" "9.13" "2.59" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10453" "26747" "ENSG00000083635" "NUFIP1" "hsa:26747; Q8WVM5; Q96SG1; Q9UHK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428917072824426789" "False" "High" "IsMasterProtein" "Q8NDV7" "Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2" "0.005" "False" "2.287" "1" "1" "1" "1" "1962" "210.2" "7.01" "2.08" "1" "stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf10427, Pf16608" "27327" "ENSG00000090905" "TNRC6A" "C9JAR8; hsa:27327; O15408; Q658L5; Q6NVB5; Q8NDV7; Q8NEZ0; Q8TBT8; Q8TCR0; Q9NV59; Q9P268" "" "MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Ca2+ pathway; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8250639024737902778" "False" "High" "IsMasterProtein" "O14727" "Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2" "0.005" "False" "2.276" "1" "1" "1" "1" "1248" "141.7" "6.40" "2.17" "1" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00619, Pf00931, Pf17908, Pf21296" "317" "ENSG00000120868" "APAF1" "B2RMX8; hsa:317; O14727; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9" "miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Neutrophil degranulation; Transcriptional Regulation by E2F6; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.005" "False" "2.276" "2" "1" "1" "1" "464" "53.3" "8.57" "2.61" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.005" "False" "2.276" "4" "1" "1" "1" "282" "31.5" "4.55" "2.66" "1" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.005" "False" "2.276" "3" "1" "1" "1" "291" "33.6" "8.28" "2.24" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "2q13 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921315881662704994" "False" "High" "IsMasterProtein" "O15040" "Tectonin beta-propeller repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=TECPR2 PE=1 SV=4" "0.005" "False" "2.275" "1" "1" "1" "1" "1411" "153.8" "5.55" "2.60" "1" "other metabolic processes;transport" "other cell component" "" "Pf06462, Pf19193" "9895" "ENSG00000196663" "TECPR2" "A5PKY3; A6NFY9; A7E2X3; H0YMM9; hsa:9895; O15040; Q9UEG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9045329245485250049" "False" "High" "IsMasterProtein" "Q9BW66" "Cyclin-dependent kinase 2-interacting protein OS=Homo sapiens OX=9606 GN=CINP PE=1 SV=1" "0.005" "False" "2.274" "4" "1" "1" "1" "212" "24.3" "6.28" "3.00" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "" "51550" "ENSG00000100865" "CINP" "F5H7P3; F5H8A7; hsa:51550; Q9BW66; Q9NPF9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201775609484186021" "False" "High" "IsMasterProtein" "O75385" "Serine/threonine-protein kinase ULK1 OS=Homo sapiens OX=9606 GN=ULK1 PE=1 SV=2" "0.005" "False" "2.264" "1" "1" "1" "1" "1050" "112.6" "8.79" "2.61" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12063, Pf21127" "8408" "ENSG00000177169" "ULK1" "hsa:8408; O75385; Q9UQ28" "Target of rapamycin signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "RAB GEFs exchange GTP for GDP on RABs; Regulation of TNFR1 signaling; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy" "20" "0" "1.112" "0.933" "1.186" "1.241" "0.969" "1.225" "1.278" "1.157" "1.136" "65.1" "72.4" "60.8" "77.2" "80.8" "63.1" "79.8" "83.2" "75.4" "74.0" "" "" "" "" "" "" "" "" "" "" "65.1" "61.3" "38.4" "56.3" "66.2" "49.0" "61.5" "71.6" "58.8" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6352204715538572597" "False" "High" "IsMasterProtein" "Q2VPB7" "AP-5 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP5B1 PE=1 SV=4" "0.005" "False" "2.263" "1" "1" "1" "1" "878" "93.9" "5.92" "2.83" "1" "transport" "other membranes;other cytoplasmic organelle" "" "Pf21587, Pf21588, Pf21589, Pf21590" "91056" "ENSG00000254470" "AP5B1" "A1L0S6; H6WUK2; hsa:91056; Q0D2Q2; Q2VPB7; Q8N3J7; Q8WYH6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5281205603675225167" "False" "High" "IsMasterProtein" "Q9NX76" "CKLF-like MARVEL transmembrane domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CMTM6 PE=1 SV=1" "0.005" "False" "2.259" "5" "1" "1" "1" "183" "20.4" "5.29" "2.88" "1" "transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "" "Pf01284" "54918" "ENSG00000091317" "CMTM6" "hsa:54918; Q6IAC4; Q9NX76" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000189900637042825" "False" "High" "IsMasterProtein" "Q6JQN1" "Acyl-CoA dehydrogenase family member 10 OS=Homo sapiens OX=9606 GN=ACAD10 PE=1 SV=1" "0.005" "False" "2.258" "1" "1" "1" "1" "1059" "118.8" "8.06" "2.64" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00441, Pf00702, Pf01636, Pf02770, Pf02771" "80724" "ENSG00000111271" "ACAD10" "G3XAJ0; hsa:80724; Q6JQN1; Q8N828; Q8NAP2; Q96BX5" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5948729275611586048" "False" "High" "IsMasterProtein" "Q70IA6" "MOB kinase activator 2 OS=Homo sapiens OX=9606 GN=MOB2 PE=1 SV=1" "0.006" "False" "2.256" "3" "1" "1" "1" "237" "26.9" "6.79" "2.56" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "81532" "ENSG00000182208; ENSG00000291442" "MOB2" "B4DKP3; hsa:81532; Q70IA6; Q96M67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.006" "False" "2.251" "10" "1" "1" "1" "133" "15.2" "5.80" "2.36" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2071252542434870891" "False" "High" "IsMasterProtein" "Q5VU43" "Myomegalin OS=Homo sapiens OX=9606 GN=PDE4DIP PE=1 SV=3" "0.006" "False" "2.242" "0" "1" "1" "1" "2346" "264.9" "5.47" "2.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06758, Pf07989" "9659" "ENSG00000178104" "PDE4DIP" "A0A0A0MRM0; A0A0C4DFQ0; A2RU15; E9PL24; hsa:9659; O75042; O75065; Q2YDC1; Q5VU42; Q5VU43; Q5VU44; Q5VU45; Q5VU46; Q5VU47; Q5VU48; Q5VU49; Q68DU2; Q6AZ93; Q6PK88; Q86T40; Q86TB2; Q8N3W0; Q8TAY9; Q9HCP2; Q9HCP3; Q9HCP4; Q9HCP5" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45093919059166366" "False" "High" "IsMasterProtein" "O96018" "Amyloid-beta A4 precursor protein-binding family A member 3 OS=Homo sapiens OX=9606 GN=APBA3 PE=1 SV=1" "0.006" "False" "2.238" "2" "1" "2" "1" "575" "61.4" "4.94" "4.72" "1" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00595, Pf00640" "9546" "ENSG00000011132" "APBA3" "hsa:9546; O60483; O96018; Q9UPZ2" "" "Neurexins and neuroligins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010506436641867552" "False" "High" "IsMasterProtein" "Q8WWW0" "Ras association domain-containing protein 5 OS=Homo sapiens OX=9606 GN=RASSF5 PE=1 SV=1" "0.006" "False" "2.233" "2" "1" "1" "1" "418" "47.1" "9.14" "3.35" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00130, Pf00788, Pf16517" "83593" "ENSG00000266094" "RASSF5" "A8K1E6; hsa:83593; Q5SY32; Q8WWV9; Q8WWW0; Q8WXF4; Q9BT99" "Fibrin complement receptor 3 signaling pathway; Ras signaling; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "" "5" "0" "1.039" "0.903" "0.917" "1.053" "0.885" "0.929" "1.109" "0.841" "0.902" "144.1" "149.7" "130.1" "132.2" "151.7" "127.6" "133.9" "159.8" "121.2" "130.0" "" "" "" "" "" "" "" "" "" "" "144.1" "126.6" "82.3" "96.4" "124.3" "99.1" "103.2" "137.4" "94.6" "116.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2588914150961402946" "False" "High" "IsMasterProtein" "Q9H492" "Microtubule-associated proteins 1A/1B light chain 3A OS=Homo sapiens OX=9606 GN=MAP1LC3A PE=1 SV=2" "0.006" "False" "2.228" "6" "1" "1" "1" "121" "14.3" "8.68" "2.20" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "84557" "ENSG00000101460" "MAP1LC3A" "E1P5P4; E1P5P5; hsa:84557; Q9BXW5; Q9H492" "Nanoparticle triggered autophagic cell death; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; CAMKK2 pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343796778633741074" "False" "High" "IsMasterProtein" "Q9NPI1" "Bromodomain-containing protein 7 OS=Homo sapiens OX=9606 GN=BRD7 PE=1 SV=1" "0.006" "False" "2.227" "1" "1" "1" "1" "651" "74.1" "6.39" "2.57" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf12024" "29117" "ENSG00000166164" "BRD7" "hsa:29117; Q4VC09; Q8N2L9; Q96KA4; Q9BV48; Q9NPI1; Q9UH59" "" "Regulation of TP53 Activity through Acetylation" "1" "0" "1.114" "0.830" "0.975" "1.184" "0.909" "1.143" "1.341" "0.862" "1.000" "38.3" "42.7" "31.8" "37.3" "45.3" "34.8" "43.8" "51.4" "33.0" "38.3" "" "" "" "" "" "" "" "" "" "" "38.3" "36.1" "20.1" "27.2" "37.1" "27.0" "33.8" "44.2" "25.8" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8887953044378161653" "False" "High" "IsMasterProtein" "Q9UPR0" "Inactive phospholipase C-like protein 2 OS=Homo sapiens OX=9606 GN=PLCL2 PE=1 SV=2" "0.006" "False" "2.225" "1" "1" "1" "1" "1127" "125.8" "6.90" "2.76" "1" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23228" "ENSG00000154822; ENSG00000284017" "PLCL2" "A8K5V4; hsa:23228; Q8N498; Q9H8L0; Q9UFP9; Q9UPR0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7972073683050353884" "False" "High" "IsMasterProtein" "Q9NYP3" "Protein downstream neighbor of Son OS=Homo sapiens OX=9606 GN=DONSON PE=1 SV=2" "0.006" "False" "2.221" "1" "1" "1" "1" "566" "62.7" "8.66" "2.54" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "" "" "29980" "ENSG00000159147" "DONSON" "hsa:29980; Q8NC53; Q9NSR9; Q9NVZ5; Q9NYP1; Q9NYP2; Q9NYP3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.006" "False" "2.217" "8" "1" "1" "1" "123" "14.5" "11.05" "3.28" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569145288368118726" "False" "High" "IsMasterProtein" "Q9NZE8" "Large ribosomal subunit protein bL35m OS=Homo sapiens OX=9606 GN=MRPL35 PE=1 SV=3" "0.006" "False" "2.206" "4" "1" "1" "1" "188" "21.5" "11.30" "1.94" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01632" "51318" "ENSG00000132313" "MRPL35" "A6NKV6; B2RB93; hsa:51318; Q658U7; Q8WWA2; Q9NZE8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "763377976952146126" "False" "High" "IsMasterProtein" "Q6PF04" "Zinc finger protein 613 OS=Homo sapiens OX=9606 GN=ZNF613 PE=1 SV=2" "0.006" "False" "2.206" "1" "1" "1" "1" "617" "70.1" "8.92" "2.68" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "79898" "ENSG00000176024" "ZNF613" "hsa:79898; Q6PF04; Q96SS9" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4583007171926660229" "False" "High" "IsMasterProtein" "Q9H1I8" "Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3" "0.006" "False" "2.206" "1" "1" "2" "1" "757" "86.3" "5.16" "5.57" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf02845" "84164" "ENSG00000100325" "ASCC2" "B7Z8E0; F5H6J9; hsa:84164; Q4TT54; Q8TAZ0; Q9H1I8; Q9H711; Q9H9D6" "" "ALKBH3 mediated reversal of alkylation damage" "1" "0" "1.072" "1.075" "1.064" "1.089" "1.041" "1.096" "1.070" "1.035" "1.042" "146.5" "157.0" "157.4" "156.0" "159.5" "152.5" "160.6" "156.8" "151.7" "152.7" "" "" "" "" "" "" "" "" "" "" "146.5" "132.8" "99.6" "113.7" "130.7" "118.5" "123.8" "134.8" "118.4" "137.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-499196435734005468" "False" "High" "IsMasterProtein" "Q96GJ1" "tRNA (uracil-5-)-methyltransferase homolog B OS=Homo sapiens OX=9606 GN=TRMT2B PE=1 SV=1" "0.006" "False" "2.195" "2" "1" "1" "1" "504" "56.4" "8.81" "1.72" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf05958" "79979" "ENSG00000188917" "TRMT2B" "A6NDG5; A6NEI9; A6NMG6; hsa:79979; Q5JPF0; Q5JVY6; Q96GJ1; Q96HU7; Q96IH9; Q9H9K2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "257698658833668232" "False" "High" "IsMasterProtein" "A7E2V4" "Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZSWIM8 PE=1 SV=1" "0.006" "False" "2.195" "0" "1" "1" "1" "1837" "197.2" "6.80" "2.95" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf21055" "23053" "ENSG00000214655" "ZSWIM8" "A7E2V4; B2RP37; hsa:23053; O94987; Q17RS8; Q2TAB8; Q6P439; Q8IW81; Q8NB34; Q9H8F3" "" "Regulation of expression of SLITs and ROBOs" "1" "0" "1.112" "0.747" "0.943" "0.966" "0.784" "1.057" "1.058" "0.836" "0.936" "135.7" "150.9" "101.4" "127.9" "131.0" "106.4" "143.4" "143.5" "113.5" "127.0" "" "" "" "" "" "" "" "" "" "" "135.7" "127.6" "64.1" "93.2" "107.3" "82.6" "110.6" "123.4" "88.6" "114.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.006" "False" "2.194" "4" "1" "1" "1" "188" "21.6" "9.77" "2.93" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "" "Glutamate Neurotransmitter Release Cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.006" "False" "2.194" "1" "1" "1" "1" "785" "80.6" "7.34" "2.90" "1" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "42" "0" "1.056" "0.944" "1.192" "1.118" "0.924" "1.014" "1.221" "0.870" "1.112" "80.4" "84.9" "75.9" "95.9" "89.9" "74.3" "81.5" "98.2" "70.0" "89.4" "" "" "" "" "" "" "" "" "" "" "80.4" "71.8" "48.0" "69.9" "73.7" "57.7" "62.8" "84.4" "54.6" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054198857384115692" "False" "High" "IsMasterProtein" "O14492" "SH2B adapter protein 2 OS=Homo sapiens OX=9606 GN=SH2B2 PE=1 SV=2" "0.006" "False" "2.190" "2" "1" "1" "1" "632" "67.7" "6.27" "2.89" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf08916" "10603" "ENSG00000160999" "SH2B2" "A0A0A0MTI2; A6ND74; O14492" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling" "Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production" "5" "0" "0.834" "0.608" "0.880" "0.967" "0.729" "0.888" "0.760" "0.721" "0.721" "50.9" "42.5" "31.0" "44.8" "49.2" "37.1" "45.2" "38.7" "36.7" "36.7" "" "" "" "" "" "" "" "" "" "" "50.9" "35.9" "19.6" "32.7" "40.3" "28.8" "34.9" "33.3" "28.7" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.006" "False" "2.186" "10" "1" "3" "1" "70" "8.2" "10.10" "6.91" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "1.113" "1.284" "1.188" "1.119" "1.488" "1.330" "1.075" "1.742" "1.158" "40.7" "45.3" "52.3" "48.4" "45.6" "60.6" "54.2" "43.8" "71.0" "47.2" "" "" "" "" "" "" "" "" "" "" "40.7" "38.4" "33.1" "35.3" "37.4" "47.1" "41.8" "37.7" "55.4" "42.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8613494787005004283" "False" "High" "IsMasterProtein" "Q9BWJ5" "Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1" "0.006" "False" "2.185" "13" "1" "1" "1" "86" "10.1" "6.35" "3.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07189" "83443" "ENSG00000169976" "SF3B5" "B2R568; hsa:83443; Q7RTV1; Q9BWJ5" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2659436389650332532" "False" "High" "IsMasterProtein" "Q8TEQ0" "Sorting nexin-29 OS=Homo sapiens OX=9606 GN=SNX29 PE=1 SV=3" "0.006" "False" "2.183" "1" "1" "1" "1" "813" "91.2" "6.21" "2.28" "1" "" "" "other molecular function" "Pf00787, Pf02759" "92017" "ENSG00000048471" "SNX29" "B5MDW2; hsa:92017; Q8N2X2; Q8TEQ0; Q9HA26" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "High" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.006" "False" "2.176" "3" "1" "1" "1" "253" "28.0" "5.81" "2.84" "1" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "1.094" "1.591" "1.291" "1.183" "1.587" "1.232" "1.488" "1.447" "1.504" "54.6" "59.7" "86.9" "70.5" "64.6" "86.7" "67.3" "81.3" "79.0" "82.1" "" "" "" "" "" "" "" "" "" "" "54.6" "50.5" "55.0" "51.4" "52.9" "67.3" "51.9" "69.9" "61.7" "73.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.006" "False" "2.175" "1" "1" "1" "1" "979" "104.7" "6.29" "2.29" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "Alstrom syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5475559016249233817" "False" "High" "IsMasterProtein" "Q9NVT9" "Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1" "0.006" "False" "2.175" "3" "1" "1" "1" "282" "31.3" "5.74" "2.56" "1" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00514" "55156" "ENSG00000104442" "ARMC1" "B4E2W7; hsa:55156; Q9H018; Q9H820; Q9NVT9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.006" "False" "2.174" "3" "1" "1" "1" "302" "33.8" "6.67" "3.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "1.150" "0.929" "1.042" "1.175" "0.968" "1.028" "0.948" "0.965" "1.103" "108.5" "124.8" "100.8" "113.1" "127.5" "105.1" "111.5" "102.9" "104.7" "119.6" "" "" "" "" "" "" "" "" "" "" "108.5" "105.6" "63.7" "82.5" "104.4" "81.6" "86.0" "88.4" "81.7" "107.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6902866621778883125" "False" "High" "IsMasterProtein" "P04004" "Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 SV=1" "0.006" "True" "2.174" "3" "1" "1" "1" "478" "54.3" "5.80" "2.35" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00045, Pf01033" "7448" "ENSG00000109072" "VTN" "B2R7G0; hsa:7448; P01141; P04004; Q9BSH7" "Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity" "Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750052983451588697" "False" "High" "IsMasterProtein" "O43166" "Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4" "0.007" "False" "2.170" "0" "1" "1" "1" "1804" "199.9" "8.19" "2.34" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "26037" "ENSG00000197555" "SIPA1L1" "hsa:26037; J3KP19; O43166; O95321; Q9UDU4; Q9UNU4" "" "Neurexins and neuroligins" "1" "0" "1.057" "1.493" "1.135" "1.121" "1.327" "1.018" "0.894" "1.418" "1.041" "43.1" "45.6" "64.4" "49.0" "48.4" "57.2" "43.9" "38.6" "61.1" "44.9" "" "" "" "" "" "" "" "" "" "" "43.1" "38.6" "40.7" "35.7" "39.6" "44.4" "33.8" "33.2" "47.7" "40.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7182714032381137149" "False" "High" "IsMasterProtein" "P55058" "Phospholipid transfer protein OS=Homo sapiens OX=9606 GN=PLTP PE=1 SV=1" "0.007" "False" "2.165" "2" "1" "1" "1" "493" "54.7" "7.01" "2.51" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus" "transporter activity;other molecular function" "Pf01273, Pf02886" "5360" "ENSG00000100979" "PLTP" "A8K006; B4DDD5; B4DRB4; E1P5N8; E7EV16; hsa:5360; P55058; Q8WTT1; Q9BR07; Q9BSH8" "PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Cholesterol metabolism" "" "10" "0" "1.098" "1.235" "1.265" "1.326" "0.982" "1.018" "1.084" "1.136" "1.093" "23.6" "25.9" "29.1" "29.8" "31.3" "23.1" "24.0" "25.6" "26.8" "25.8" "" "" "" "" "" "" "" "" "" "" "23.6" "21.9" "18.4" "21.7" "25.6" "18.0" "18.5" "22.0" "20.9" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1123362264700484507" "False" "High" "IsMasterProtein" "Q9Y3R0" "Glutamate receptor-interacting protein 1 OS=Homo sapiens OX=9606 GN=GRIP1 PE=1 SV=3" "0.007" "False" "2.163" "1" "1" "2" "1" "1128" "122.3" "6.47" "4.68" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00595, Pf17820" "23426" "ENSG00000155974" "GRIP1" "C9JT59; hsa:23426; Q1RLM0; Q9Y3R0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system" "Trafficking of GluR2-containing AMPA receptors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1649578185394976597" "False" "High" "IsMasterProtein" "Q9UHC1" "DNA mismatch repair protein Mlh3 OS=Homo sapiens OX=9606 GN=MLH3 PE=1 SV=3" "0.007" "False" "2.157" "1" "1" "1" "1" "1453" "163.6" "6.73" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf02518, Pf08676" "27030" "ENSG00000119684" "MLH3" "hsa:27030; P49751; Q56DK9; Q9P292; Q9UHC0; Q9UHC1" "Male infertility" "Meiotic recombination" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "High" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.007" "False" "2.155" "8" "1" "1" "1" "112" "13.2" "9.99" "2.05" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "409285405643847618" "False" "High" "IsMasterProtein" "Q96N21" "AP-4 complex accessory subunit Tepsin OS=Homo sapiens OX=9606 GN=TEPSIN PE=1 SV=1" "0.007" "False" "2.154" "2" "1" "1" "1" "525" "55.1" "7.03" "2.68" "1" "" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01417" "146705" "ENSG00000167302" "TEPSIN" "hsa:146705; Q6ZQU0; Q6ZSQ9; Q96N21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.007" "False" "2.154" "2" "1" "1" "1" "392" "43.9" "8.91" "2.63" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7198210632893501960" "False" "High" "IsMasterProtein" "Q07864" "DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5" "0.007" "False" "2.152" "0" "1" "1" "1" "2286" "261.4" "6.39" "1.89" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08490" "5426" "ENSG00000177084" "POLE" "hsa:5426; Q07864; Q13533; Q86VH9" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7618289525843205014" "False" "High" "IsMasterProtein" "Q7L8W6" "Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3" "0.007" "False" "2.151" "3" "1" "1" "1" "267" "30.3" "5.40" "2.89" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01902" "89978" "ENSG00000134146" "DPH6" "B3KWG1; hsa:89978; Q7L8W6; Q96HJ6" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.141" "0.960" "1.408" "1.153" "1.093" "1.385" "1.241" "0.859" "1.221" "54.2" "61.9" "52.0" "76.3" "62.5" "59.2" "75.1" "67.2" "46.5" "66.2" "" "" "" "" "" "" "" "" "" "" "54.2" "52.3" "32.9" "55.6" "51.2" "46.0" "57.9" "57.8" "36.3" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711116662832737595" "False" "High" "IsMasterProtein" "Q53EZ4" "Centrosomal protein of 55 kDa OS=Homo sapiens OX=9606 GN=CEP55 PE=1 SV=3" "0.007" "False" "2.147" "2" "1" "1" "1" "464" "54.1" "7.01" "2.76" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf12180" "55165" "ENSG00000138180" "CEP55" "B2RDG8; D3DR37; hsa:55165; Q32WF5; Q3MV20; Q53EZ4; Q5VY28; Q6N034; Q96H32; Q9NVS7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.007" "False" "2.146" "9" "1" "1" "1" "129" "14.2" "9.07" "2.47" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-130690685770980429" "False" "High" "IsMasterProtein" "Q9NWS6" "Protein FAM118A OS=Homo sapiens OX=9606 GN=FAM118A PE=1 SV=2" "0.007" "False" "2.146" "3" "1" "1" "1" "357" "40.2" "6.09" "2.05" "1" "" "other membranes" "other molecular function" "Pf13289" "55007" "ENSG00000100376" "FAM118A" "B3KWG4; B4DY02; hsa:55007; Q5TII5; Q96CY3; Q9NWS6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485687817967320227" "False" "High" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "0.007" "False" "2.145" "4" "1" "1" "1" "293" "33.2" "8.10" "2.80" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "0.979" "0.975" "0.824" "0.910" "0.954" "0.873" "0.918" "0.830" "0.943" "38.7" "37.9" "37.8" "31.9" "35.3" "37.0" "33.8" "35.6" "32.2" "36.5" "" "" "" "" "" "" "" "" "" "" "38.7" "32.1" "23.9" "23.3" "28.9" "28.7" "26.1" "30.6" "25.1" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172225001989641453" "False" "High" "IsMasterProtein" "Q9UNW1" "Multiple inositol polyphosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=MINPP1 PE=1 SV=1" "0.007" "False" "2.142" "1" "1" "1" "1" "487" "55.0" "7.81" "2.87" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00328" "9562" "ENSG00000107789" "MINPP1" "F5H683; hsa:9562; O95172; O95286; Q59EJ2; Q9UGA3; Q9UNW1" "" "Synthesis of IPs in the ER lumen" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4531692626450091838" "False" "High" "IsMasterProtein" "Q05BQ5" "MBT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBTD1 PE=1 SV=2" "0.007" "False" "2.140" "1" "1" "1" "1" "628" "70.5" "7.77" "2.13" "1" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02820, Pf21319" "54799" "ENSG00000011258" "MBTD1" "hsa:54799; Q05BQ5; Q6ZVU7; Q9NXU1" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7225540634492564749" "False" "High" "IsMasterProtein" "Cont_Q0VCM5" "Inter-alpha-trypsin inhibitor heavy chain H1 OS=Bos taurus OX=9913 GN=ITIH1 PE=1 SV=1" "0.007" "True" "2.139" "1" "1" "1" "1" "906" "101.2" "7.40" "2.79" "1" "other metabolic processes" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "508356" "ENSBTAG00000007843" "ITIH1" "bta:508356; Q0VCM5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2596521025155403540" "False" "High" "IsMasterProtein" "Q9BXM9" "FSD1-like protein OS=Homo sapiens OX=9606 GN=FSD1L PE=1 SV=2" "0.008" "False" "2.137" "2" "1" "1" "1" "530" "59.5" "6.20" "2.94" "1" "" "" "" "Pf00622" "83856" "ENSG00000106701" "FSD1L" "A2A338; A6NKH7; B7Z5S6; B7Z5W3; hsa:83856; Q5T879; Q5T880; Q9BXM9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2922734994360900835" "False" "High" "IsMasterProtein" "P54198" "Protein HIRA OS=Homo sapiens OX=9606 GN=HIRA PE=1 SV=2" "0.008" "False" "2.136" "1" "1" "1" "1" "1017" "111.8" "8.07" "2.75" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf07569" "7290" "ENSG00000100084" "HIRA" "hsa:7290; P54198; Q05BU9; Q8IXN2" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); Replacement of protamines by nucleosomes in the male pronucleus" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1090044883093451685" "False" "High" "IsMasterProtein" "Q6PGQ7" "Protein aurora borealis OS=Homo sapiens OX=9606 GN=BORA PE=1 SV=2" "0.008" "False" "2.135" "1" "1" "1" "1" "559" "61.2" "4.94" "2.38" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15280" "79866" "ENSG00000136122" "BORA" "B4DQ30; hsa:79866; Q5W0P3; Q5W0P4; Q6PGQ7; Q86YC6; Q96IW9; Q9H640" "" "Regulation of PLK1 Activity at G2/M Transition" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594022568560112109" "False" "High" "IsMasterProtein" "Q14627" "Interleukin-13 receptor subunit alpha-2 OS=Homo sapiens OX=9606 GN=IL13RA2 PE=1 SV=1" "0.008" "False" "2.133" "2" "1" "1" "1" "380" "44.1" "4.97" "0.00" "1" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf09240" "3598" "ENSG00000123496" "IL13RA2" "A8K7E2; hsa:3598; O00667; Q14627" "" "Interleukin-4 and Interleukin-13 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.008" "False" "2.130" "0" "1" "1" "1" "2961" "330.9" "5.95" "2.44" "1" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "1.106" "1.111" "1.180" "1.185" "1.354" "1.169" "1.357" "1.405" "1.321" "37.5" "41.4" "41.6" "44.2" "44.4" "50.8" "43.8" "50.9" "52.7" "49.5" "" "" "" "" "" "" "" "" "" "" "37.5" "35.1" "26.3" "32.2" "36.4" "39.4" "33.8" "43.7" "41.1" "44.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "High" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.009" "False" "2.120" "4" "1" "1" "1" "180" "20.4" "8.51" "2.85" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.239" "1.141" "1.042" "1.196" "1.329" "1.071" "1.027" "1.282" "1.391" "119.4" "147.9" "136.2" "124.4" "142.8" "158.7" "127.9" "122.6" "153.1" "166.1" "" "" "" "" "" "" "" "" "" "" "119.4" "125.1" "86.1" "90.7" "117.0" "123.3" "98.6" "105.4" "119.5" "149.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "High" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.009" "False" "2.117" "4" "1" "1" "1" "217" "24.3" "8.59" "2.84" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "" "Ubiquinol biosynthesis" "1" "0" "1.156" "0.972" "0.979" "1.115" "1.045" "1.054" "0.971" "0.937" "1.260" "101.4" "117.2" "98.6" "99.2" "113.0" "106.0" "106.8" "98.4" "95.0" "127.8" "" "" "" "" "" "" "" "" "" "" "101.4" "99.1" "62.3" "72.4" "92.6" "82.3" "82.4" "84.6" "74.1" "114.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1798322026652807896" "False" "High" "IsMasterProtein" "Q5VTU8" "ATP synthase subunit epsilon-like protein, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1EP2 PE=1 SV=1" "0.009" "False" "2.115" "14" "1" "1" "1" "51" "5.8" "10.14" "3.22" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "" "" "ATP5F1EP2" "Q5VTU8" "" "" "0" "0" "0.944" "1.017" "0.870" "0.926" "0.933" "0.937" "0.879" "0.988" "1.021" "191.9" "181.2" "195.1" "166.9" "177.8" "179.0" "179.8" "168.7" "189.6" "196.0" "" "" "" "" "" "" "" "" "" "" "191.9" "153.3" "123.4" "121.7" "145.6" "139.0" "138.6" "145.1" "148.0" "176.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.009" "False" "2.112" "2" "1" "1" "1" "476" "53.0" "7.23" "2.53" "1" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2190048182398586679" "False" "High" "IsMasterProtein" "Q9NRX5" "Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1" "0.009" "False" "2.108" "2" "1" "1" "1" "453" "50.5" "5.85" "2.35" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03348" "57515" "ENSG00000111897" "SERINC1" "B3KY69; E1P565; hsa:57515; O75655; Q7Z2F5; Q8TAG1; Q9NRX5; Q9NTH8; Q9ULG7" "Sphingolipid pathway" "Serine biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3706953300411127023" "False" "High" "IsMasterProtein" "Cont_Q1RMN8" "Immunoglobulin light chain, lambda gene cluster OS=Bos taurus OX=9913 GN=IGL PE=2 SV=1" "0.009" "True" "2.105" "3" "1" "1" "1" "234" "24.5" "7.62" "2.82" "1" "" "" "" "Pf07654, Pf07686" "" "" "IGL@" "Q1RMN8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7832305992449282077" "False" "High" "IsMasterProtein" "Q8NHJ6" "Leukocyte immunoglobulin-like receptor subfamily B member 4 OS=Homo sapiens OX=9606 GN=LILRB4 PE=1 SV=3" "0.009" "False" "2.104" "2" "1" "1" "1" "448" "49.3" "6.67" "2.46" "1" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00047, Pf13895" "11006" "ENSG00000186818; ENSG00000275730" "LILRB4" "A8MVL8; hsa:11006; O15468; O75021; Q6FGQ9; Q8N1C7; Q8NHJ6; Q8NHL5" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "1" "0" "1.147" "0.826" "1.292" "1.069" "0.860" "1.190" "1.117" "0.701" "1.089" "38.1" "43.7" "31.5" "49.2" "40.7" "32.8" "45.3" "42.6" "26.7" "41.5" "" "" "" "" "" "" "" "" "" "" "38.1" "37.0" "19.9" "35.9" "33.4" "25.4" "35.0" "36.6" "20.8" "37.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.009" "False" "2.103" "5" "1" "1" "1" "159" "17.6" "5.26" "3.04" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2133311852660354058" "False" "High" "IsMasterProtein" "P49795" "Regulator of G-protein signaling 19 OS=Homo sapiens OX=9606 GN=RGS19 PE=1 SV=1" "0.009" "False" "2.101" "6" "1" "1" "1" "217" "24.6" "5.62" "2.18" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00615" "10287" "ENSG00000171700" "RGS19" "A8K216; E1P5G9; hsa:10287; P49795; Q53XN0; Q8TD60" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7468753572846518438" "False" "High" "IsMasterProtein" "Q9NYF0" "Dapper homolog 1 OS=Homo sapiens OX=9606 GN=DACT1 PE=1 SV=2" "0.009" "False" "2.087" "1" "1" "1" "1" "836" "90.1" "8.69" "2.46" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15268" "51339" "ENSG00000165617" "DACT1" "A8MYJ2; hsa:51339; Q86TY0; Q9NYF0" "" "Degradation of DVL" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3152501174739967590" "False" "High" "IsMasterProtein" "Q8IXT5" "RNA-binding protein 12B OS=Homo sapiens OX=9606 GN=RBM12B PE=1 SV=2" "0.009" "False" "2.087" "1" "1" "1" "1" "1001" "118.0" "6.81" "2.52" "1" "other biological processes" "nucleus;other cell component" "" "Pf00076" "389677" "ENSG00000183808" "RBM12B" "A8MYB5; hsa:389677; Q8IXT5" "" "" "0" "0" "0.995" "0.852" "1.011" "0.995" "1.007" "1.086" "1.225" "0.989" "0.948" "60.6" "60.3" "51.6" "61.2" "60.3" "61.0" "65.8" "74.2" "59.9" "57.4" "" "" "" "" "" "" "" "" "" "" "60.6" "51.0" "32.6" "44.6" "49.4" "47.4" "50.7" "63.8" "46.8" "51.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "High" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.010" "False" "2.081" "1" "1" "1" "1" "1056" "116.2" "5.48" "0.00" "1" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "2q13 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.010" "False" "2.081" "6" "1" "1" "1" "131" "14.7" "5.10" "2.55" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "Acute viral myocarditis" "" "1" "0" "0.998" "1.277" "1.401" "1.187" "0.995" "1.092" "1.006" "1.154" "0.911" "54.2" "54.0" "69.2" "75.9" "64.3" "53.9" "59.2" "54.5" "62.5" "49.3" "" "" "" "" "" "" "" "" "" "" "54.2" "45.7" "43.8" "55.3" "52.7" "41.9" "45.6" "46.8" "48.8" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2913038286527379435" "False" "High" "IsMasterProtein" "Q6PL45" "BRICHOS domain-containing protein 5 OS=Homo sapiens OX=9606 GN=BRICD5 PE=1 SV=3" "0.010" "False" "2.080" "3" "1" "2" "1" "260" "28.5" "7.30" "5.09" "1" "other biological processes" "non-structural extracellular;other membranes" "" "Pf04089" "283870" "ENSG00000182685" "BRICD5" "C9J7K2; hsa:283870; Q6PL45; Q8IXU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3098042065705187363" "False" "High" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "0.010" "False" "2.080" "1" "1" "1" "1" "605" "68.2" "4.74" "2.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "IL-18 signaling pathway" "Condensation of Prophase Chromosomes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626223979709161938" "False" "High" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "0.010" "False" "2.075" "2" "1" "1" "1" "385" "44.3" "5.38" "3.23" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.010" "False" "2.074" "4" "1" "1" "1" "221" "26.1" "9.79" "3.25" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "1.148" "1.248" "1.187" "1.161" "1.514" "1.324" "0.995" "1.242" "1.179" "40.0" "46.0" "50.0" "47.6" "46.5" "60.6" "53.0" "39.8" "49.7" "47.2" "" "" "" "" "" "" "" "" "" "" "40.0" "38.9" "31.6" "34.7" "38.1" "47.1" "40.9" "34.2" "38.8" "42.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-226173209616136915" "False" "High" "IsMasterProtein" "Q96D53" "Atypical kinase COQ8B, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8B PE=1 SV=2" "0.010" "False" "2.073" "2" "1" "1" "1" "544" "60.0" "7.23" "2.18" "1" "other metabolic processes;developmental processes" "plasma membrane;other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf03109" "79934" "ENSG00000123815" "COQ8B" "hsa:79934; Q8TAJ1; Q96D53; Q9HA52" "Nephrotic syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.010" "False" "2.071" "6" "1" "1" "1" "194" "21.8" "8.15" "2.96" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "" "RAB geranylgeranylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "High" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.010" "False" "2.066" "5" "1" "1" "1" "171" "20.0" "8.92" "2.15" "1" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "0.963" "0.718" "0.764" "0.598" "0.807" "1.246" "1.218" "0.917" "1.068" "19.1" "18.4" "13.7" "14.6" "11.4" "15.4" "23.8" "23.2" "17.5" "20.4" "" "" "" "" "" "" "" "" "" "" "19.1" "15.5" "8.7" "10.6" "9.3" "11.9" "18.3" "20.0" "13.6" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "High" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.010" "False" "2.063" "1" "1" "1" "1" "1082" "120.1" "7.28" "2.26" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "mRNA processing" "" "1" "0" "1.307" "0.988" "1.229" "0.991" "1.060" "1.216" "1.113" "1.147" "1.069" "25.1" "32.8" "24.8" "30.8" "24.9" "26.6" "30.5" "27.9" "28.8" "26.8" "" "" "" "" "" "" "" "" "" "" "25.1" "27.7" "15.7" "22.5" "20.4" "20.7" "23.5" "24.0" "22.5" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.010" "False" "2.062" "1" "1" "1" "1" "1097" "115.6" "4.40" "0.00" "1" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "" "VLDL clearance" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665398799840712854" "False" "High" "IsMasterProtein" "Q5VWJ9" "Sorting nexin-30 OS=Homo sapiens OX=9606 GN=SNX30 PE=1 SV=1" "0.010" "False" "2.061" "3" "1" "1" "1" "437" "49.6" "5.35" "2.30" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf03114" "401548" "ENSG00000148158" "SNX30" "hsa:401548; Q5VWJ9" "" "" "0" "0" "0.925" "1.042" "1.293" "1.232" "1.153" "1.354" "1.340" "0.752" "1.163" "30.5" "28.2" "31.8" "39.4" "37.6" "35.2" "41.3" "40.9" "22.9" "35.5" "" "" "" "" "" "" "" "" "" "" "30.5" "23.9" "20.1" "28.8" "30.8" "27.3" "31.8" "35.2" "17.9" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8127793230594197368" "False" "High" "IsMasterProtein" "Q9ULH1" "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" "0.010" "False" "2.054" "1" "1" "1" "1" "1129" "125.4" "7.31" "2.28" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf14604, Pf16746" "50807" "ENSG00000153317" "ASAP1" "B2RNV3; hsa:50807; Q9ULH1" "EGF/EGFR signaling pathway; CCL18 signaling pathway" "VxPx cargo-targeting to cilium" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.010" "False" "2.052" "3" "1" "1" "1" "258" "29.2" "9.01" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "1.033" "0.847" "0.895" "0.904" "0.803" "0.965" "0.866" "0.805" "0.893" "142.8" "147.6" "121.0" "127.9" "129.1" "114.7" "137.8" "123.7" "115.0" "127.5" "" "" "" "" "" "" "" "" "" "" "142.8" "124.8" "76.5" "93.3" "105.8" "89.1" "106.2" "106.3" "89.8" "114.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.010" "False" "2.052" "1" "1" "1" "1" "1057" "118.5" "6.19" "2.67" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6814802731580382634" "False" "High" "IsMasterProtein" "Q6SJ96" "TATA box-binding protein-like 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=2" "0.010" "False" "2.048" "2" "1" "1" "1" "343" "38.0" "5.74" "2.42" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "387332" "ENSG00000182521" "TBPL2" "hsa:387332; Q17RU8; Q6SJ96" "" "Germ layer formation at gastrulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.010" "False" "2.047" "2" "1" "1" "1" "519" "59.1" "5.76" "2.24" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Hematopoietic stem cell differentiation" "Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "0.911" "0.836" "0.898" "1.018" "0.975" "0.988" "1.023" "1.015" "1.061" "62.6" "57.0" "52.3" "56.2" "63.7" "61.0" "61.9" "64.0" "63.6" "66.4" "" "" "" "" "" "" "" "" "" "" "62.6" "48.2" "33.1" "41.0" "52.2" "47.4" "47.7" "55.1" "49.6" "59.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "High" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.010" "False" "2.043" "1" "1" "1" "1" "1449" "160.4" "10.89" "2.79" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5062583023050280776" "False" "High" "IsMasterProtein" "Q8NDF8" "Terminal nucleotidyltransferase 4B OS=Homo sapiens OX=9606 GN=TENT4B PE=1 SV=2" "0.010" "False" "2.043" "2" "1" "1" "1" "572" "63.2" "8.98" "1.97" "1" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf03828" "64282" "ENSG00000121274" "TENT4B" "B4DV38; hsa:64282; Q8NDF8; Q9NW67; Q9Y6C0" "15q25 copy number variation" "" "1" "0" "0.980" "0.956" "1.045" "1.101" "0.914" "0.867" "1.141" "0.955" "1.058" "46.7" "45.7" "44.6" "48.8" "51.4" "42.7" "40.5" "53.3" "44.6" "49.4" "" "" "" "" "" "" "" "" "" "" "46.7" "38.7" "28.2" "35.6" "42.1" "33.1" "31.2" "45.8" "34.8" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.010" "False" "2.040" "2" "1" "1" "1" "340" "37.3" "8.73" "2.47" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.010" "False" "2.040" "4" "1" "1" "1" "250" "27.9" "4.88" "0.00" "1" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "" "MHC class II antigen presentation; Interferon gamma signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-948672987785726372" "False" "High" "IsMasterProtein" "Q9BT25" "HAUS augmin-like complex subunit 8 OS=Homo sapiens OX=9606 GN=HAUS8 PE=1 SV=3" "0.010" "False" "2.039" "2" "1" "1" "1" "410" "44.8" "7.06" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "93323" "ENSG00000131351" "HAUS8" "B4DJA7; C9JBZ4; hsa:93323; Q49AC4; Q86WF0; Q96FX3; Q9BT25" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.097" "1.084" "1.018" "1.128" "0.937" "1.222" "0.908" "0.920" "1.084" "55.7" "61.1" "60.4" "56.7" "62.8" "52.2" "68.1" "50.6" "51.3" "60.4" "" "" "" "" "" "" "" "" "" "" "55.7" "51.7" "38.2" "41.4" "51.5" "40.6" "52.5" "43.5" "40.0" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "High" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.010" "False" "2.039" "9" "1" "1" "1" "79" "9.5" "7.87" "2.71" "1" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "" "Mitochondrial protein import" "1" "0" "0.995" "0.689" "1.055" "1.173" "0.911" "1.182" "1.094" "0.647" "0.944" "106.2" "105.7" "73.1" "112.0" "124.6" "96.7" "125.5" "116.1" "68.7" "100.2" "" "" "" "" "" "" "" "" "" "" "106.2" "89.4" "46.2" "81.7" "102.1" "75.1" "96.8" "99.8" "53.6" "90.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.010" "False" "2.038" "2" "1" "1" "1" "500" "53.9" "8.66" "3.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431267486707138909" "False" "High" "IsMasterProtein" "Q8TEA7" "TBC domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=TBCK PE=1 SV=4" "0.010" "False" "2.036" "1" "1" "1" "1" "893" "100.6" "6.58" "1.91" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00566, Pf00581" "93627" "ENSG00000145348" "TBCK" "B9A6J1; hsa:93627; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8TEA7; Q8WW57; Q96GV6; Q9P080" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4126622846664947622" "False" "High" "IsMasterProtein" "Q96H35" "Probable RNA-binding protein 18 OS=Homo sapiens OX=9606 GN=RBM18 PE=1 SV=1" "0.010" "False" "2.032" "5" "1" "1" "1" "190" "21.6" "9.44" "2.21" "1" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "92400" "ENSG00000119446" "RBM18" "B3KQ89; hsa:92400; Q96H35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043676364934071043" "False" "High" "IsMasterProtein" "Q14254" "Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2" "0.010" "False" "2.030" "2" "1" "1" "1" "428" "47.0" "5.25" "2.36" "1" "cell adhesion;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "" "Pf01145" "2319" "ENSG00000132589" "FLOT2" "hsa:2319; Q14254" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Regulation of necroptotic cell death; RND1 GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RND3 GTPase cycle; Synaptic adhesion-like molecules" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9154021296598643510" "False" "High" "IsMasterProtein" "Q495B1" "Ankyrin repeat and death domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKDD1A PE=1 SV=2" "0.010" "False" "2.028" "2" "1" "1" "1" "522" "57.5" "6.71" "0.00" "1" "signal transduction" "" "" "Pf12796" "348094" "ENSG00000166839" "ANKDD1A" "hsa:348094; Q495B1; Q495B2; Q495B3; Q8N7A0; Q8NBS5" "" "" "0" "0" "1.226" "0.899" "1.124" "1.112" "1.022" "1.005" "0.959" "1.017" "1.100" "156.6" "192.0" "140.8" "176.1" "174.2" "160.0" "157.5" "150.3" "159.3" "172.3" "" "" "" "" "" "" "" "" "" "" "156.6" "162.4" "89.1" "128.4" "142.7" "124.3" "121.4" "129.2" "124.3" "154.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1149947407616018825" "False" "High" "IsMasterProtein" "Q9NTX7" "E3 ubiquitin-protein ligase RNF146 OS=Homo sapiens OX=9606 GN=RNF146 PE=1 SV=1" "0.010" "False" "2.027" "4" "1" "1" "1" "359" "38.9" "5.33" "0.00" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02825, Pf13920" "81847" "ENSG00000118518" "RNF146" "E1P572; hsa:81847; Q6FIB2; Q7L8H4; Q96K03; Q96T06; Q9NTX6; Q9NTX7" "" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.010" "False" "2.024" "1" "1" "1" "1" "993" "112.8" "5.57" "2.50" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2631004439744677845" "False" "High" "IsMasterProtein" "P04637" "Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4" "0.010" "False" "2.022" "2" "1" "1" "1" "393" "43.6" "6.79" "2.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00870, Pf07710, Pf08563, Pf18521" "7157" "ENSG00000141510" "TP53" "hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Hereditary leiomyomatosis and renal cell carcinoma pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in progeria; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Zygotic genome activation (ZGA); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Regulation of TP53 Degradation; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional activation of cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability" "116" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2598464737050709238" "False" "High" "IsMasterProtein" "Q96LD8" "Sentrin-specific protease 8 OS=Homo sapiens OX=9606 GN=SENP8 PE=1 SV=1" "0.010" "False" "2.021" "3" "1" "1" "1" "212" "24.1" "5.97" "3.33" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf02902" "123228" "ENSG00000166192" "SENP8" "hsa:123228; Q96LD8; Q96QA4" "" "Neddylation; UCH proteinases" "2" "0" "0.947" "0.975" "1.033" "0.963" "1.100" "0.998" "0.961" "0.960" "0.954" "138.6" "131.2" "135.1" "143.1" "133.4" "152.4" "138.3" "133.1" "133.1" "132.3" "" "" "" "" "" "" "" "" "" "" "138.6" "111.0" "85.4" "104.3" "109.3" "118.3" "106.6" "114.4" "103.9" "118.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.010" "False" "2.021" "7" "1" "1" "1" "107" "12.1" "9.64" "3.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.920" "0.881" "0.839" "0.858" "0.900" "0.890" "0.886" "0.836" "0.821" "212.2" "195.2" "187.1" "178.0" "182.2" "191.0" "188.9" "188.0" "177.4" "174.3" "" "" "" "" "" "" "" "" "" "" "212.2" "165.1" "118.3" "129.8" "149.2" "148.4" "145.6" "161.6" "138.4" "156.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764296312378698476" "False" "High" "IsMasterProtein" "Q9UHJ3" "Scm-like with four MBT domains protein 1 OS=Homo sapiens OX=9606 GN=SFMBT1 PE=1 SV=2" "0.010" "False" "2.014" "1" "1" "1" "1" "866" "98.1" "6.21" "2.85" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140" "51460" "ENSG00000163935" "SFMBT1" "hsa:51460; Q402F7; Q96C73; Q9UHJ3; Q9Y4Q9" "" "" "0" "0" "1.099" "0.882" "1.159" "1.056" "0.977" "1.273" "1.185" "0.936" "0.956" "67.5" "74.2" "59.5" "78.3" "71.3" "66.0" "85.9" "80.0" "63.2" "64.5" "" "" "" "" "" "" "" "" "" "" "67.5" "62.8" "37.6" "57.1" "58.4" "51.2" "66.2" "68.8" "49.4" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9132064026440102154" "False" "High" "IsMasterProtein" "Q8NCD3" "Holliday junction recognition protein OS=Homo sapiens OX=9606 GN=HJURP PE=1 SV=2" "0.010" "False" "2.011" "1" "1" "1" "1" "748" "83.5" "9.31" "2.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10384, Pf12346, Pf12347" "55355" "ENSG00000123485" "HJURP" "A8IRH5; B4DWR0; B4DZV4; hsa:55355; Q8NCD3; Q9BUT2; Q9NSL8" "2q37 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6386992515294996358" "False" "High" "IsMasterProtein" "Q8IUZ5" "5-phosphohydroxy-L-lysine phospho-lyase OS=Homo sapiens OX=9606 GN=PHYKPL PE=1 SV=1" "0.010" "False" "2.009" "3" "1" "1" "1" "450" "49.7" "6.76" "2.61" "1" "" "mitochondrion" "other molecular function" "Pf00202" "85007" "ENSG00000175309" "PHYKPL" "A8K7P6; B3KN36; D3DWP9; hsa:85007; Q8IUZ5; Q8WYS6; Q96HW8" "" "Lysine catabolism; Collagen degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751858567189414303" "False" "Medium" "IsMasterProtein" "Q9Y4U1" "Cyanocobalamin reductase / alkylcobalamin dealkylase OS=Homo sapiens OX=9606 GN=MMACHC PE=1 SV=3" "0.010" "False" "2.005" "3" "1" "1" "1" "282" "31.7" "7.81" "2.68" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf16690" "25974" "ENSG00000132763" "MMACHC" "hsa:25974; Q5T157; Q9BRQ7; Q9Y4U1" "" "Cobalamin (Cbl) metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC" "3" "0" "1.115" "0.689" "0.969" "1.142" "0.864" "0.986" "1.117" "0.827" "0.957" "110.7" "123.4" "76.2" "107.3" "126.4" "95.6" "109.1" "123.7" "91.6" "105.9" "" "" "" "" "" "" "" "" "" "" "110.7" "104.4" "48.2" "78.2" "103.5" "74.2" "84.1" "106.3" "71.5" "95.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163626551938173047" "False" "Medium" "IsMasterProtein" "P27987" "Inositol-trisphosphate 3-kinase B OS=Homo sapiens OX=9606 GN=ITPKB PE=1 SV=5" "0.010" "False" "2.004" "1" "1" "1" "1" "946" "102.3" "8.43" "2.84" "1" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "3707" "ENSG00000143772" "ITPKB" "hsa:3707; P27987; Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47" "CCL18 signaling pathway" "Synthesis of IP3 and IP4 in the cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "Medium" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.010" "False" "1.994" "2" "1" "1" "1" "384" "43.4" "5.96" "2.79" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "Ciliary landscape" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8314832949912610149" "False" "Medium" "IsMasterProtein" "Q9H0T7" "Ras-related protein Rab-17 OS=Homo sapiens OX=9606 GN=RAB17 PE=1 SV=2" "0.010" "False" "1.993" "5" "1" "1" "1" "212" "23.5" "7.84" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "64284" "ENSG00000124839" "RAB17" "hsa:64284; Q53QV6; Q6IA73; Q6PJZ0; Q9BVU1; Q9H0T7; Q9H9U9" "2q37 copy number variation syndrome" "RAB geranylgeranylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8492326486630770538" "False" "Medium" "IsMasterProtein" "Q8NFA0" "Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens OX=9606 GN=USP32 PE=1 SV=1" "0.010" "False" "1.992" "1" "1" "1" "1" "1604" "181.5" "6.44" "2.04" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf06337, Pf13202, Pf14836" "84669" "ENSG00000170832" "USP32" "hsa:84669; Q7Z5T3; Q8NFA0; Q9BX85; Q9Y591" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1242134690800435233" "False" "Medium" "IsMasterProtein" "Q155Q3" "Dixin OS=Homo sapiens OX=9606 GN=DIXDC1 PE=1 SV=2" "0.010" "False" "1.990" "1" "1" "1" "1" "683" "77.4" "6.24" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00778" "85458" "ENSG00000150764" "DIXDC1" "A1A5D8; E9PRV4; hsa:85458; Q155Q3; Q6P2J8; Q6PIK4; Q86SR7; Q8IVY4; Q96N69; Q9C0C8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "Medium" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.010" "False" "1.988" "1" "1" "1" "1" "703" "77.9" "6.24" "3.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "12" "0" "1.077" "1.222" "1.082" "1.051" "1.160" "0.924" "1.217" "1.187" "1.085" "68.6" "73.9" "83.8" "74.2" "72.1" "79.6" "63.4" "83.5" "81.5" "74.5" "" "" "" "" "" "" "" "" "" "" "68.6" "62.5" "53.0" "54.1" "59.1" "61.8" "48.9" "71.8" "63.6" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "Medium" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.011" "False" "1.982" "0" "1" "1" "1" "3114" "357.3" "5.10" "2.41" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Gastric cancer network 1; Ciliopathies" "Polo-like kinase mediated events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "0.992" "0.698" "1.163" "1.157" "0.845" "1.258" "1.090" "1.056" "1.032" "75.7" "75.1" "52.8" "88.1" "87.6" "64.0" "95.2" "82.5" "79.9" "78.1" "" "" "" "" "" "" "" "" "" "" "75.7" "63.5" "33.4" "64.2" "71.8" "49.7" "73.4" "71.0" "62.4" "70.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5928345399775878911" "False" "Medium" "IsMasterProtein" "Q9H5Z1" "Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens OX=9606 GN=DHX35 PE=1 SV=2" "0.011" "False" "1.971" "1" "1" "1" "1" "703" "78.9" "8.59" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00271, Pf04408, Pf07717, Pf21010" "60625" "ENSG00000101452" "DHX35" "A2RTX3; B4E0J0; F5GXM6; hsa:60625; Q5THR0; Q9H4H7; Q9H5Z1; Q9H6T6" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990155463246362264" "False" "Medium" "IsMasterProtein" "Q8NHB8" "Olfactory receptor 5K2 OS=Homo sapiens OX=9606 GN=OR5K2 PE=1 SV=3" "0.012" "False" "1.967" "2" "1" "1" "1" "316" "35.7" "8.06" "2.76" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "402135" "ENSG00000231861" "OR5K2" "B2RN70; hsa:402135; Q6IF47; Q8NHB8" "" "Expression and translocation of olfactory receptors" "1" "0" "1.220" "1.360" "1.156" "1.292" "1.558" "1.347" "1.224" "1.352" "1.193" "102.9" "125.5" "139.9" "119.0" "133.0" "160.3" "138.6" "125.9" "139.2" "122.7" "" "" "" "" "" "" "" "" "" "" "102.9" "106.2" "88.5" "86.7" "109.0" "124.5" "106.8" "108.3" "108.6" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033266282732166818" "False" "Medium" "IsMasterProtein" "Q9Y663" "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1" "0.012" "False" "1.965" "2" "1" "1" "1" "406" "44.9" "9.50" "2.86" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00685" "9955" "ENSG00000153976" "HS3ST3A1" "A8K7N2; hsa:9955; Q9Y663" "Glycosaminoglycan synthesis in fibroblasts; Metapathway biotransformation Phase I and II" "HS-GAG biosynthesis" "3" "0" "1.193" "0.960" "1.171" "1.064" "1.122" "1.220" "1.249" "1.212" "1.190" "55.6" "66.3" "53.4" "65.1" "59.2" "62.4" "67.8" "69.4" "67.4" "66.2" "" "" "" "" "" "" "" "" "" "" "55.6" "56.1" "33.7" "47.5" "48.5" "48.4" "52.3" "59.7" "52.6" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3215128447752590217" "False" "Medium" "IsMasterProtein" "A2RUS2" "DENN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2" "0.012" "False" "1.965" "1" "1" "1" "1" "1198" "135.8" "7.06" "2.61" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02141, Pf03456" "22898" "ENSG00000105339" "DENND3" "A2RUS2; B7ZM28; hsa:22898; O94947; Q2TAM7; Q6ZMS6; Q96DK3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7426344905124172545" "False" "Medium" "IsMasterProtein" "Q9BR61" "Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1" "0.012" "False" "1.963" "2" "1" "1" "1" "282" "31.1" "5.11" "2.69" "1" "" "cytosol" "other molecular function" "Pf00887, Pf12796" "84320" "ENSG00000230124" "ACBD6" "hsa:84320; Q9BR61" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.883" "0.802" "0.913" "0.944" "0.921" "1.101" "0.976" "0.787" "0.913" "104.2" "91.9" "83.6" "95.1" "98.4" "95.9" "114.7" "101.6" "82.0" "95.1" "" "" "" "" "" "" "" "" "" "" "104.2" "77.8" "52.8" "69.4" "80.6" "74.5" "88.4" "87.4" "64.0" "85.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7273665205180060624" "False" "Medium" "IsMasterProtein" "O14830" "Serine/threonine-protein phosphatase with EF-hands 2 OS=Homo sapiens OX=9606 GN=PPEF2 PE=1 SV=2" "0.012" "False" "1.953" "2" "1" "1" "1" "753" "86.5" "7.14" "1.64" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00036, Pf00149, Pf08321, Pf13202" "5470" "ENSG00000156194" "PPEF2" "hsa:5470; O14830; O14831" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739885640391199971" "False" "Medium" "IsMasterProtein" "Q8IY57" "YY1-associated factor 2 OS=Homo sapiens OX=9606 GN=YAF2 PE=1 SV=3" "0.012" "False" "1.951" "14" "1" "1" "1" "180" "19.9" "9.72" "0.00" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "10138" "ENSG00000015153" "YAF2" "A8K5P0; B4DFU3; G3V465; hsa:10138; Q8IY57; Q99710" "" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-3558019273629961963" "False" "Medium" "IsMasterProtein" "Q13424" "Alpha-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTA1 PE=1 SV=1" "0.012" "False" "1.948" "2" "1" "1" "1" "505" "53.9" "6.80" "2.50" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6640" "ENSG00000101400" "SNTA1" "A8K7H9; B4DX40; E1P5N1; hsa:6640; Q13424; Q16438" "13q12.12 copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "2" "0" "1.131" "1.215" "1.272" "1.163" "1.016" "1.181" "1.333" "1.182" "1.193" "70.1" "79.3" "85.2" "89.1" "81.5" "71.2" "82.8" "93.4" "82.9" "83.6" "" "" "" "" "" "" "" "" "" "" "70.1" "67.1" "53.9" "65.0" "66.8" "55.3" "63.8" "80.3" "64.7" "75.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "Medium" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.012" "False" "1.947" "2" "1" "1" "1" "693" "76.4" "8.54" "2.84" "1" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "Downstream TCR signaling; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623935666392123134" "False" "Medium" "IsMasterProtein" "Q8N653" "Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens OX=9606 GN=LZTR1 PE=1 SV=2" "0.012" "False" "1.946" "1" "1" "1" "1" "840" "94.7" "6.57" "2.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00651, Pf01344, Pf13415, Pf13418" "8216" "ENSG00000099949" "LZTR1" "hsa:8216; Q14776; Q20WK0; Q8N653" "22q11.2 copy number variation syndrome" "" "1" "0" "0.809" "0.689" "0.797" "0.908" "0.729" "0.878" "0.994" "0.691" "0.883" "160.4" "129.8" "110.6" "127.8" "145.6" "116.9" "140.9" "159.4" "110.9" "141.7" "" "" "" "" "" "" "" "" "" "" "160.4" "109.8" "69.9" "93.2" "119.3" "90.8" "108.6" "137.1" "86.5" "127.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2082394650260842040" "False" "Medium" "IsMasterProtein" "Q6P4A8" "Phospholipase B-like 1 OS=Homo sapiens OX=9606 GN=PLBD1 PE=1 SV=2" "0.012" "False" "1.945" "2" "1" "1" "1" "553" "63.2" "9.06" "2.22" "1" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf04916" "79887" "ENSG00000121316" "PLBD1" "A8K4E9; hsa:79887; Q6P4A8; Q9BVV3; Q9H625" "" "Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6282194941215119925" "False" "Medium" "IsMasterProtein" "Q9HAW0" "Transcription factor IIIB 50 kDa subunit OS=Homo sapiens OX=9606 GN=BRF2 PE=1 SV=1" "0.012" "False" "1.945" "2" "1" "1" "1" "419" "46.5" "7.94" "2.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08271" "55290" "ENSG00000104221" "BRF2" "B2RD62; B4DFZ6; D3DSW6; hsa:55290; Q9H2Y3; Q9H3B3; Q9HAW0; Q9NUY6" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5850729463523374244" "False" "Medium" "IsMasterProtein" "Q6UWL6" "Kin of IRRE-like protein 2 OS=Homo sapiens OX=9606 GN=KIRREL2 PE=1 SV=3" "0.012" "False" "1.944" "1" "1" "1" "1" "708" "75.0" "6.73" "2.39" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf07679, Pf08205, Pf13927" "84063" "ENSG00000126259" "KIRREL2" "C9JHF1; C9JJ76; F1T0I2; hsa:84063; Q6P1R1; Q6UWL6; Q7Z5P1; Q7Z5P2; Q96IQ8; Q9H0T1" "Primary focal segmental glomerulosclerosis (FSGS)" "Nephrin family interactions" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8783162572127248995" "False" "Medium" "IsMasterProtein" "Q9H4A5" "Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1" "0.012" "False" "1.944" "2" "1" "1" "1" "285" "32.7" "5.83" "2.78" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05719" "55204" "ENSG00000143457" "GOLPH3L" "B1AN09; B7Z6N3; hsa:55204; Q9H4A5; Q9NVK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1768337099241243287" "False" "Medium" "IsMasterProtein" "Q08ET2" "Sialic acid-binding Ig-like lectin 14 OS=Homo sapiens OX=9606 GN=SIGLEC14 PE=1 SV=1" "0.012" "False" "1.943" "2" "1" "1" "1" "396" "43.9" "7.96" "2.46" "1" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf07686, Pf08205, Pf13895" "100049587" "ENSG00000254415" "SIGLEC14" "hsa:100049587; Q08ET2; Q6UXG0" "" "Neutrophil degranulation; DAP12 interactions" "2" "0" "1.335" "1.410" "1.172" "1.323" "1.323" "1.331" "1.264" "1.298" "1.328" "62.0" "82.8" "87.4" "72.7" "82.1" "82.1" "82.5" "78.4" "80.5" "82.4" "" "" "" "" "" "" "" "" "" "" "62.0" "70.1" "55.3" "53.0" "67.2" "63.7" "63.6" "67.4" "62.8" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3056828042948797118" "False" "Medium" "IsMasterProtein" "Q9Y5B6" "PAX3- and PAX7-binding protein 1 OS=Homo sapiens OX=9606 GN=PAXBP1 PE=1 SV=2" "0.012" "False" "1.942" "2" "1" "1" "1" "917" "104.7" "5.68" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf07842" "94104" "ENSG00000159086; ENSG00000263141" "PAXBP1" "D3DSE7; hsa:94104; Q96DU8; Q9NYQ0; Q9Y5B6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "Medium" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.012" "False" "1.939" "2" "1" "1" "1" "458" "52.7" "9.11" "2.67" "1" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-470190640123372826" "False" "Medium" "IsMasterProtein" "Q8WXD2" "Secretogranin-3 OS=Homo sapiens OX=9606 GN=SCG3 PE=1 SV=3" "0.012" "False" "1.929" "1" "1" "1" "1" "468" "53.0" "5.03" "2.77" "1" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "" "Pf15467" "29106" "ENSG00000104112" "SCG3" "A8K2B0; B3KQP6; B4DK99; F5H3R8; hsa:29106; Q8WXD2; Q96C83; Q96GE8; Q9Y6G7" "" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1794648964700596183" "False" "Medium" "IsMasterProtein" "Q00013" "55 kDa erythrocyte membrane protein OS=Homo sapiens OX=9606 GN=MPP1 PE=1 SV=2" "0.012" "False" "1.928" "3" "1" "1" "1" "466" "52.3" "7.37" "0.00" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;kinase activity" "Pf00018, Pf00595, Pf00625" "4354" "ENSG00000130830" "MPP1" "B4DZV5; G3XAI1; hsa:4354; Q00013; Q2TSB6; Q5J7V5" "MECP2 and associated Rett syndrome" "Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2086395098636375665" "False" "Medium" "IsMasterProtein" "Q96Q89" "Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3" "0.012" "False" "1.928" "0" "1" "1" "1" "1820" "210.5" "5.67" "2.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9585" "ENSG00000138182" "KIF20B" "A8MXM7; hsa:9585; O43277; Q09471; Q2KQ73; Q32NE1; Q561V3; Q58EX8; Q5T9M8; Q5T9M9; Q5T9N0; Q5T9N1; Q7KZ68; Q7Z5E0; Q7Z5E1; Q7Z6M9; Q86X82; Q96Q89; Q9H3R8; Q9H6Q9; Q9H755; Q9NTC1; Q9UFR5" "Gastric cancer network 1" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "0.946" "0.636" "1.096" "1.129" "0.651" "0.925" "1.148" "0.858" "1.061" "55.2" "52.2" "35.1" "60.6" "62.4" "36.0" "51.1" "63.4" "47.4" "58.6" "" "" "" "" "" "" "" "" "" "" "55.2" "44.2" "22.2" "44.2" "51.1" "27.9" "39.4" "54.5" "37.0" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "Medium" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.012" "False" "1.927" "2" "1" "1" "1" "482" "53.5" "8.51" "2.47" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1674970657433919693" "False" "Medium" "IsMasterProtein" "P51159" "Ras-related protein Rab-27A OS=Homo sapiens OX=9606 GN=RAB27A PE=1 SV=3" "0.012" "False" "1.926" "5" "1" "1" "1" "221" "24.9" "5.22" "2.65" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5873" "ENSG00000069974" "RAB27A" "hsa:5873; O00195; P51159; Q6FI40; Q9UIR9; Q9Y5U3" "Deregulation of Rab and Rab effector genes in bladder cancer; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; 2q37 copy number variation syndrome" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Insulin processing" "7" "0" "1.136" "1.030" "0.923" "1.017" "0.992" "0.813" "0.804" "0.979" "1.048" "28.4" "32.3" "29.3" "26.2" "28.9" "28.2" "23.1" "22.9" "27.8" "29.8" "" "" "" "" "" "" "" "" "" "" "28.4" "27.3" "18.5" "19.1" "23.7" "21.9" "17.8" "19.7" "21.7" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8871370198028658557" "False" "Medium" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "0.012" "False" "1.926" "2" "1" "1" "1" "288" "33.6" "11.25" "2.98" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "Medium" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.012" "False" "1.925" "6" "1" "1" "1" "115" "12.4" "4.37" "2.61" "1" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "17q12 copy number variation syndrome" "" "1" "0" "1.222" "1.263" "1.095" "1.095" "1.497" "1.001" "1.124" "1.163" "1.139" "39.0" "47.6" "49.3" "42.7" "42.7" "58.4" "39.0" "43.8" "45.3" "44.4" "" "" "" "" "" "" "" "" "" "" "39.0" "40.3" "31.1" "31.1" "35.0" "45.3" "30.1" "37.7" "35.4" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4077783620514139312" "False" "Medium" "IsMasterProtein" "Q15650" "Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4" "0.012" "False" "1.925" "2" "1" "1" "1" "581" "66.1" "7.85" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04266, Pf06221" "9325" "ENSG00000103671" "TRIP4" "B2RAS0; hsa:9325; Q15650; Q96ED7; Q9UKH0" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "Medium" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.012" "False" "1.922" "1" "1" "1" "1" "1907" "213.6" "4.84" "2.95" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "Medium" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.012" "False" "1.919" "4" "1" "1" "1" "160" "18.6" "10.49" "2.96" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "Medium" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.012" "False" "1.918" "4" "1" "1" "1" "361" "38.3" "4.72" "2.22" "1" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "Acute viral myocarditis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3487009987400899106" "False" "Medium" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "0.012" "False" "1.910" "2" "1" "1" "1" "313" "34.6" "9.32" "2.93" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "Base excision repair; DNA repair pathways, full network" "Chromatin modifications during the maternal to zygotic transition (MZT)" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2807988249818990777" "False" "Medium" "IsMasterProtein" "P78545" "ETS-related transcription factor Elf-3 OS=Homo sapiens OX=9606 GN=ELF3 PE=1 SV=1" "0.012" "False" "1.907" "2" "1" "1" "1" "371" "41.4" "5.77" "2.52" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "1999" "ENSG00000163435" "ELF3" "B2R5Q6; hsa:1999; P78545; Q6IAP8; Q7RU03; Q7Z3X2; Q8NFG2; Q99718" "" "Pre-NOTCH Transcription and Translation" "1" "0" "1.121" "0.832" "1.120" "0.965" "1.165" "1.092" "1.144" "1.062" "1.122" "80.1" "89.8" "66.6" "89.6" "77.2" "93.2" "87.4" "91.6" "85.0" "89.8" "" "" "" "" "" "" "" "" "" "" "80.1" "75.9" "42.1" "65.3" "63.3" "72.4" "67.4" "78.7" "66.4" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "Medium" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.012" "False" "1.905" "0" "1" "1" "1" "1871" "215.9" "6.21" "2.06" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "Mesodermal commitment pathway" "RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "1.096" "1.100" "1.039" "1.392" "1.300" "0.890" "0.986" "1.253" "1.147" "53.6" "58.7" "58.9" "55.6" "74.5" "69.6" "47.7" "52.8" "67.1" "61.4" "" "" "" "" "" "" "" "" "" "" "53.6" "49.7" "37.3" "40.6" "61.1" "54.1" "36.7" "45.4" "52.4" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "Medium" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.012" "False" "1.904" "1" "1" "1" "1" "494" "53.7" "4.87" "2.10" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1737151228857093329" "False" "Medium" "IsMasterProtein" "A6NNY8" "Ubiquitin carboxyl-terminal hydrolase 27 OS=Homo sapiens OX=9606 GN=USP27X PE=1 SV=3" "0.013" "False" "1.899" "2" "1" "1" "1" "438" "49.6" "7.18" "2.63" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "389856" "ENSG00000273820" "USP27X" "A6NNY8; hsa:389856" "" "" "0" "0" "1.055" "1.108" "1.119" "1.067" "1.086" "1.136" "1.172" "1.073" "1.026" "98.9" "104.4" "109.6" "110.7" "105.6" "107.5" "112.3" "115.9" "106.1" "101.5" "" "" "" "" "" "" "" "" "" "" "98.9" "88.3" "69.3" "80.7" "86.5" "83.4" "86.6" "99.7" "82.8" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "Medium" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.013" "False" "1.894" "3" "1" "1" "1" "268" "29.0" "5.40" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3309717020774859274" "False" "Medium" "IsMasterProtein" "Q96GQ7" "Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens OX=9606 GN=DDX27 PE=1 SV=2" "0.013" "False" "1.890" "1" "1" "1" "1" "796" "89.8" "9.28" "3.02" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "55661" "" "DDX27" "A0AVB6; B7ZLY1; Q5VXM7; Q8WYG4; Q969N7; Q96F57; Q96GQ7; Q96L97; Q9BWY9; Q9BXF0; Q9H990; Q9NWU3; Q9P0C2; Q9UGD6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "Medium" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.013" "False" "1.885" "1" "1" "1" "1" "547" "59.5" "5.43" "2.64" "1" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Ebola virus infection in host" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "Medium" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.013" "False" "1.880" "12" "1" "1" "1" "106" "11.7" "6.79" "2.01" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369587105980304302" "False" "Medium" "IsMasterProtein" "P08F94" "Fibrocystin OS=Homo sapiens OX=9606 GN=PKHD1 PE=1 SV=1" "0.013" "False" "1.876" "0" "1" "1" "1" "4074" "446.4" "6.57" "1.93" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01833, Pf10162, Pf13229" "5314" "ENSG00000170927" "PKHD1" "hsa:5314; P08F94; Q5VUA2; Q5VUA3; Q5VWV1; Q86Z26; Q8TCZ9" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "1.276" "1.130" "1.096" "1.031" "0.995" "0.903" "1.303" "0.858" "1.160" "12.6" "16.1" "14.2" "13.8" "13.0" "12.5" "11.4" "16.4" "10.8" "14.6" "" "" "" "" "" "" "" "" "" "" "12.6" "13.6" "9.0" "10.1" "10.6" "9.7" "8.8" "14.1" "8.4" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7398915680383575894" "False" "Medium" "IsMasterProtein" "Q5BKX5" "Actin maturation protease OS=Homo sapiens OX=9606 GN=ACTMAP PE=1 SV=2" "0.013" "False" "1.875" "3" "1" "1" "1" "351" "37.8" "7.47" "2.41" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf21646" "284325" "ENSG00000188493" "ACTMAP" "A8MSZ5; B4DNU7; hsa:284325; Q5BKX5" "" "" "0" "0" "0.977" "0.960" "1.017" "1.080" "1.058" "0.998" "1.119" "1.053" "1.073" "76.1" "74.4" "73.1" "77.4" "82.2" "80.6" "76.0" "85.2" "80.2" "81.7" "" "" "" "" "" "" "" "" "" "" "76.1" "62.9" "46.2" "56.5" "67.4" "62.6" "58.6" "73.2" "62.6" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "Medium" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.013" "False" "1.874" "4" "1" "1" "1" "220" "23.3" "6.61" "3.27" "1" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "1.199" "1.117" "1.031" "1.076" "1.034" "1.199" "1.130" "0.891" "1.150" "73.7" "88.4" "82.3" "76.0" "79.3" "76.2" "88.4" "83.3" "65.7" "84.7" "" "" "" "" "" "" "" "" "" "" "73.7" "74.8" "52.1" "55.4" "65.0" "59.2" "68.1" "71.6" "51.3" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4026716302863274085" "False" "Medium" "IsMasterProtein" "Q5T5X7" "BEN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=BEND3 PE=1 SV=1" "0.013" "False" "1.871" "1" "1" "1" "1" "828" "94.4" "5.43" "2.06" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10523" "57673" "ENSG00000178409" "BEND3" "A2RRH2; hsa:57673; Q5T5X7; Q9HCL9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1909180657852220732" "False" "Medium" "IsMasterProtein" "P57679" "EvC complex member EVC OS=Homo sapiens OX=9606 GN=EVC PE=1 SV=1" "0.013" "False" "1.871" "1" "1" "2" "1" "992" "111.9" "6.73" "4.15" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "" "" "2121" "ENSG00000072840" "EVC" "hsa:2121; P57679" "Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "Activation of SMO" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1704533537262305790" "False" "Medium" "IsMasterProtein" "Q5VXH5" "PRAME family member 7 OS=Homo sapiens OX=9606 GN=PRAMEF7 PE=2 SV=2" "0.013" "False" "1.868" "3" "1" "1" "1" "474" "53.6" "6.38" "2.07" "1" "other biological processes" "other cell component" "" "" "441871" "ENSG00000204510; ENSG00000279195" "PRAMEF7" "A0A087X1I7; A0A0A6YYA1; B9EIP0; hsa:441871; Q5VXH5" "" "" "0" "0" "0.967" "0.858" "0.852" "1.178" "1.340" "1.556" "1.026" "0.988" "1.068" "158.9" "153.6" "136.3" "135.3" "187.1" "212.9" "247.2" "163.0" "156.9" "169.6" "" "" "" "" "" "" "" "" "" "" "158.9" "130.0" "86.2" "98.7" "153.3" "165.4" "190.6" "140.2" "122.5" "152.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6434237713970420089" "False" "Medium" "IsMasterProtein" "Q9Y291" "Small ribosomal subunit protein mS33 OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1" "0.013" "False" "1.867" "8" "1" "1" "1" "106" "12.6" "10.11" "1.87" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08293" "51650" "ENSG00000090263" "MRPS33" "hsa:51650; Q9Y291" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300467232994524401" "False" "Medium" "IsMasterProtein" "Q8NBX0" "Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens OX=9606 GN=SCCPDH PE=1 SV=1" "0.013" "False" "1.867" "2" "1" "1" "1" "429" "47.1" "9.14" "2.66" "1" "other metabolic processes" "non-structural extracellular;other cell component" "other molecular function" "Pf03435" "51097" "ENSG00000143653" "SCCPDH" "hsa:51097; Q8NBX0; Q8TAR0; Q9Y363" "" "Platelet degranulation" "1" "0" "1.094" "1.090" "1.080" "1.174" "1.076" "1.017" "1.076" "1.121" "1.026" "146.5" "160.3" "159.6" "158.2" "172.0" "157.6" "149.0" "157.7" "164.2" "150.4" "" "" "" "" "" "" "" "" "" "" "146.5" "135.6" "100.9" "115.4" "140.9" "122.4" "114.9" "135.6" "128.2" "135.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7265627926791616515" "False" "Medium" "IsMasterProtein" "Q96RY5" "Protein cramped-like OS=Homo sapiens OX=9606 GN=CRAMP1 PE=1 SV=3" "0.014" "False" "1.857" "1" "1" "1" "1" "1269" "134.6" "7.87" "2.20" "1" "developmental processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "57585" "ENSG00000007545" "CRAMP1" "A8MZL1; B1AJY1; hsa:57585; Q8NDN1; Q96RY5; Q9P2C1" "" "" "0" "0" "0.896" "0.753" "1.004" "0.884" "0.792" "0.820" "0.885" "0.829" "0.944" "66.0" "59.2" "49.7" "66.3" "58.4" "52.3" "54.2" "58.4" "54.7" "62.3" "" "" "" "" "" "" "" "" "" "" "66.0" "50.0" "31.4" "48.3" "47.8" "40.6" "41.8" "50.2" "42.7" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9095276718227916136" "False" "Medium" "IsMasterProtein" "Q8IUG5" "Unconventional myosin-XVIIIb OS=Homo sapiens OX=9606 GN=MYO18B PE=1 SV=2" "0.014" "False" "1.855" "0" "1" "1" "1" "2567" "285.0" "6.86" "0.00" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063" "84700" "ENSG00000133454" "MYO18B" "A0A075B6F5; B2RWP3; F5GXR6; F5GYU7; hsa:84700; Q8IUG5; Q8NDI8; Q8TE65; Q8WWS0; Q96KH2; Q96KR8; Q96KR9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7815504497160521648" "False" "Medium" "IsMasterProtein" "Q01826" "DNA-binding protein SATB1 OS=Homo sapiens OX=9606 GN=SATB1 PE=1 SV=1" "0.014" "False" "1.854" "1" "1" "1" "1" "763" "85.9" "6.54" "3.44" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376, Pf16534, Pf16557" "6304" "ENSG00000182568" "SATB1" "B3KXF1; C9JTR6; hsa:6304; Q01826; Q59EQ0" "Vitamin D receptor pathway" "SUMOylation of chromatin organization proteins; Apoptotic cleavage of cellular proteins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1393050946975624808" "False" "Medium" "IsMasterProtein" "Q9HBE1" "POZ-, AT hook-, and zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=PATZ1 PE=1 SV=1" "0.014" "False" "1.853" "1" "1" "1" "1" "687" "74.0" "8.35" "2.52" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912, Pf16637" "23598" "ENSG00000100105" "PATZ1" "hsa:23598; Q9HBE1; Q9HBE2; Q9HBE3; Q9P1A9; Q9UDU0; Q9Y529" "Androgen receptor signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "Medium" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.014" "False" "1.852" "3" "1" "1" "1" "320" "36.2" "6.16" "2.89" "1" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8030741050122894286" "False" "Medium" "IsMasterProtein" "Q9NRH2" "SNF-related serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SNRK PE=1 SV=2" "0.014" "False" "1.850" "2" "1" "1" "1" "765" "84.2" "7.06" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "54861" "ENSG00000163788" "SNRK" "B2RAV6; hsa:54861; Q14706; Q68D15; Q6IQ46; Q9NRH2; Q9NXI7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7979244283854796707" "False" "Medium" "IsMasterProtein" "Q96S90" "LysM and putative peptidoglycan-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LYSMD1 PE=1 SV=1" "0.014" "False" "1.842" "5" "1" "1" "1" "227" "25.0" "8.57" "2.24" "1" "" "nucleus" "" "Pf01476" "388695" "ENSG00000163155" "LYSMD1" "B4DQA1; hsa:388695; Q69YX9; Q96S90" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "Medium" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.014" "False" "1.838" "5" "1" "1" "1" "158" "18.0" "8.68" "2.13" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.207" "1.001" "1.043" "1.150" "1.153" "1.187" "1.089" "1.114" "1.016" "51.3" "61.9" "51.3" "53.5" "59.0" "59.2" "60.9" "55.9" "57.2" "52.2" "" "" "" "" "" "" "" "" "" "" "51.3" "52.4" "32.5" "39.0" "48.4" "45.9" "46.9" "48.1" "44.6" "46.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1822880503447006764" "False" "Medium" "IsMasterProtein" "Q9NX04" "AFG2-interacting ribosome maturation factor OS=Homo sapiens OX=9606 GN=AIRIM PE=1 SV=1" "0.014" "False" "1.838" "4" "1" "1" "1" "203" "23.4" "5.67" "2.73" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15011" "54955" "ENSG00000116922" "AIRIM" "D3DPT1; Q8WVD1; Q9NX04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266136317046350400" "False" "Medium" "IsMasterProtein" "Q70Z53" "Protein FRA10AC1 OS=Homo sapiens OX=9606 GN=FRA10AC1 PE=1 SV=3" "0.014" "False" "1.834" "2" "1" "1" "1" "315" "37.5" "8.10" "2.54" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf09725" "118924" "ENSG00000148690" "FRA10AC1" "C9JCR4; C9JCR5; C9JMY4; hsa:118924; Q70Z49; Q70Z50; Q70Z51; Q70Z52; Q70Z53; Q8N293; Q8WVH5; Q96JQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "Medium" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.014" "False" "1.832" "2" "1" "1" "1" "420" "48.4" "8.00" "2.08" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "Medium" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.014" "False" "1.830" "3" "1" "1" "1" "287" "32.4" "5.87" "2.00" "1" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1543956144810928637" "False" "Medium" "IsMasterProtein" "Q6UB98" "Ankyrin repeat domain-containing protein 12 OS=Homo sapiens OX=9606 GN=ANKRD12 PE=1 SV=3" "0.014" "False" "1.829" "1" "1" "1" "1" "2062" "235.5" "7.01" "2.60" "1" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23253" "ENSG00000101745" "ANKRD12" "hsa:23253; O94951; Q658K1; Q6QMF7; Q6UB98; Q9H231; Q9H784" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "Medium" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.014" "False" "1.829" "3" "1" "1" "1" "220" "23.3" "9.17" "1.93" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Retinoblastoma gene in cancer; Notch signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288678854882700202" "False" "Medium" "IsMasterProtein" "Q7Z3C6" "Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3" "0.014" "False" "1.827" "2" "1" "1" "1" "839" "94.4" "6.67" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf04109" "79065" "ENSG00000198925" "ATG9A" "hsa:79065; Q3ZAQ6; Q6P0N7; Q7Z317; Q7Z320; Q7Z3C6; Q8NDK6; Q8WU65; Q9BVL5; Q9H6L1; Q9HAG7" "Autophagy; Primary ovarian insufficiency" "Macroautophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "-8204272869155150803" "False" "Medium" "IsMasterProtein" "O96015" "Dynein axonemal light chain 4 OS=Homo sapiens OX=9606 GN=DNAL4 PE=1 SV=1" "0.014" "False" "1.820" "8" "1" "1" "1" "105" "12.0" "5.49" "2.11" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01221" "10126" "ENSG00000100246" "DNAL4" "hsa:10126; O96015; Q6FGB2; Q6FGD0" "" "Retrograde neurotrophin signalling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8565311044506647969" "False" "Medium" "IsMasterProtein" "Q7RTN6" "STE20-related kinase adapter protein alpha OS=Homo sapiens OX=9606 GN=STRADA PE=1 SV=1" "0.014" "False" "1.819" "2" "1" "1" "1" "431" "48.3" "6.48" "2.27" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00069" "92335" "ENSG00000266173" "STRADA" "B4DDE3; B4DW17; hsa:92335; J3KTC9; Q5JPI2; Q7RTN6; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Energy dependent regulation of mTOR by LKB1-AMPK" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "Medium" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.014" "False" "1.818" "2" "1" "1" "1" "465" "53.2" "7.85" "2.19" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "" "tRNA processing in the nucleus" "1" "0" "1.061" "0.856" "1.166" "0.975" "0.843" "0.921" "0.973" "1.083" "0.890" "111.8" "118.6" "95.7" "130.4" "109.1" "94.2" "103.0" "108.8" "121.0" "99.5" "" "" "" "" "" "" "" "" "" "" "111.8" "100.3" "60.5" "95.0" "89.3" "73.2" "79.4" "93.6" "94.5" "89.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5609078604117945067" "False" "Medium" "IsMasterProtein" "Q9H777" "Zinc phosphodiesterase ELAC protein 1 OS=Homo sapiens OX=9606 GN=ELAC1 PE=1 SV=2" "0.014" "False" "1.817" "2" "1" "1" "1" "363" "40.0" "6.79" "2.87" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00753" "55520" "ENSG00000141642" "ELAC1" "hsa:55520; Q9H777; Q9NS99" "" "" "0" "0" "0.161" "0.167" "0.174" "0.169" "0.199" "0.177" "0.173" "0.205" "0.163" "565.9" "91.2" "94.5" "98.4" "95.7" "112.6" "100.4" "98.0" "116.0" "92.0" "" "" "" "" "" "" "" "" "" "" "565.9" "77.2" "59.7" "71.7" "78.4" "87.4" "77.4" "84.2" "90.5" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "Medium" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.014" "False" "1.817" "3" "1" "1" "1" "301" "33.8" "8.88" "2.53" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "Medium" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.014" "False" "1.816" "2" "1" "1" "1" "298" "32.5" "6.32" "2.68" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Disorders of fructose metabolism; Polyol pathway" "Fructose catabolism; Essential fructosuria" "4" "0" "1.054" "1.130" "1.124" "1.148" "1.134" "1.059" "1.167" "1.338" "1.110" "78.6" "82.9" "88.8" "88.4" "90.3" "89.2" "83.3" "91.8" "105.2" "87.3" "" "" "" "" "" "" "" "" "" "" "78.6" "70.1" "56.2" "64.5" "74.0" "69.3" "64.2" "78.9" "82.1" "78.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175514539462856121" "False" "Medium" "IsMasterProtein" "Q9BT67" "NEDD4 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=NDFIP1 PE=1 SV=1" "0.014" "False" "1.813" "3" "1" "1" "1" "221" "24.9" "4.68" "2.41" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10176" "80762" "ENSG00000131507" "NDFIP1" "B2RDB8; D3DQF0; hsa:80762; Q658T8; Q8N2E3; Q8N2F9; Q9BT67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "Medium" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.014" "False" "1.812" "2" "1" "1" "1" "518" "58.4" "9.11" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1415915778275113183" "False" "Medium" "IsMasterProtein" "Q7L273" "BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1" "0.014" "False" "1.811" "3" "1" "1" "1" "389" "42.5" "6.37" "2.01" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "" "other molecular function" "Pf00805, Pf02214, Pf11834" "54793" "ENSG00000104756" "KCTD9" "hsa:54793; Q6NUM8; Q7L273; Q9NXV4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4224982315492592647" "False" "Medium" "IsMasterProtein" "A6NIE6" "Putative RRN3-like protein RRN3P2 OS=Homo sapiens OX=9606 GN=RRN3P2 PE=5 SV=3" "0.014" "False" "1.809" "3" "1" "1" "1" "340" "38.0" "5.17" "3.26" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf05327" "" "" "RRN3P2" "A6NIE6" "" "" "0" "0" "1.032" "1.119" "0.972" "1.131" "1.045" "1.197" "1.208" "1.083" "1.193" "108.6" "112.1" "121.5" "105.6" "122.9" "113.5" "130.0" "131.3" "117.7" "129.7" "" "" "" "" "" "" "" "" "" "" "108.6" "94.9" "76.8" "77.0" "100.7" "88.2" "100.2" "112.9" "91.9" "116.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4147633016877369960" "False" "Medium" "IsMasterProtein" "Q9UQ52" "Contactin-6 OS=Homo sapiens OX=9606 GN=CNTN6 PE=1 SV=1" "0.014" "False" "1.805" "1" "1" "2" "1" "1028" "113.9" "6.00" "5.67" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00041, Pf07679, Pf13927" "27255" "ENSG00000134115" "CNTN6" "hsa:27255; Q2KHM2; Q9UQ52" "Pathways affected in adenoid cystic carcinoma; Canonical and non-canonical Notch signaling" "CHL1 interactions" "3" "0" "1.213" "1.027" "0.871" "1.055" "1.012" "0.857" "1.108" "1.132" "1.093" "63.9" "77.5" "65.6" "55.7" "67.4" "64.7" "54.8" "70.8" "72.3" "69.9" "" "" "" "" "" "" "" "" "" "" "63.9" "65.6" "41.5" "40.6" "55.2" "50.2" "42.2" "60.8" "56.5" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7969959000989021007" "False" "Medium" "IsMasterProtein" "P38935" "DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3" "0.014" "False" "1.804" "1" "1" "2" "1" "993" "109.1" "8.97" "2.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01424, Pf01428, Pf13086, Pf13087, Pf21138" "3508" "ENSG00000132740" "IGHMBP2" "A0PJD2; hsa:3508; P38935; Q00443; Q14177" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "Medium" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.014" "False" "1.804" "9" "1" "1" "1" "75" "8.7" "5.45" "2.96" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin cytoskeleton" "VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "8" "0" "1.058" "0.948" "1.018" "1.159" "1.042" "1.281" "1.040" "0.916" "0.984" "66.9" "70.8" "63.4" "68.2" "77.6" "69.8" "85.8" "69.6" "61.3" "65.9" "" "" "" "" "" "" "" "" "" "" "66.9" "59.9" "40.1" "49.7" "63.6" "54.2" "66.1" "59.8" "47.9" "59.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7226837977459101745" "False" "Medium" "IsMasterProtein" "P27701" "CD82 antigen OS=Homo sapiens OX=9606 GN=CD82 PE=1 SV=1" "0.014" "False" "1.798" "4" "1" "1" "1" "267" "29.6" "5.24" "2.49" "1" "" "plasma membrane;other membranes" "" "Pf00335" "3732" "ENSG00000085117" "CD82" "D3DQN6; E9PC70; hsa:3732; P27701; Q7Z2D4; Q7Z5N2" "16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "Medium" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.014" "False" "1.798" "2" "1" "1" "1" "429" "48.7" "5.60" "2.77" "1" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "Neutrophil degranulation; Glycosphingolipid catabolism" "4" "0" "1.072" "0.922" "1.102" "1.054" "1.077" "1.252" "1.056" "1.208" "1.043" "89.0" "95.4" "82.0" "98.1" "93.8" "95.8" "111.4" "93.9" "107.4" "92.8" "" "" "" "" "" "" "" "" "" "" "89.0" "80.7" "51.8" "71.5" "76.8" "74.4" "85.9" "80.7" "83.9" "83.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6685478821626723375" "False" "Medium" "IsMasterProtein" "Q9BUB4" "tRNA-specific adenosine deaminase 1 OS=Homo sapiens OX=9606 GN=ADAT1 PE=1 SV=1" "0.014" "False" "1.797" "2" "1" "1" "1" "502" "55.4" "9.01" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf02137" "23536" "ENSG00000065457" "ADAT1" "hsa:23536; Q9BUB4; Q9NVB7; Q9UNG3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026902710649246041" "False" "Medium" "IsMasterProtein" "P14151" "L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 SV=2" "0.014" "False" "1.788" "2" "1" "1" "1" "372" "42.2" "6.60" "1.74" "1" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00008, Pf00059, Pf00084" "6402" "ENSG00000188404" "SELL" "A0A024R8Z0; B2R6Q8; hsa:6402; P14151; P15023; Q9UJ43" "Complement system; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4785441576023643711" "False" "Medium" "IsMasterProtein" "Q96EF6" "F-box only protein 17 OS=Homo sapiens OX=9606 GN=FBXO17 PE=1 SV=1" "0.014" "False" "1.787" "5" "1" "1" "1" "278" "31.5" "8.10" "2.25" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf04300, Pf12937" "115290" "ENSG00000269190; ENSG00000282954" "FBXO17" "hsa:115290; Q96EF6; Q96LQ4" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.127" "1.127" "1.336" "1.391" "1.071" "1.601" "1.324" "0.860" "0.962" "26.5" "29.9" "29.9" "35.4" "36.9" "28.4" "42.5" "35.1" "22.8" "25.5" "" "" "" "" "" "" "" "" "" "" "26.5" "25.3" "18.9" "25.8" "30.2" "22.1" "32.7" "30.2" "17.8" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986352754293277242" "False" "Medium" "IsMasterProtein" "P61513" "Large ribosomal subunit protein eL43 OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "0.014" "False" "1.785" "9" "1" "1" "1" "92" "10.3" "10.43" "2.71" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Selenocysteine synthesis; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2649804679537679892" "False" "Medium" "IsMasterProtein" "Q9H7P9" "Pleckstrin homology domain-containing family G member 2 OS=Homo sapiens OX=9606 GN=PLEKHG2 PE=1 SV=3" "0.014" "False" "1.783" "1" "1" "1" "1" "1386" "147.9" "5.86" "2.48" "1" "cell organization and biogenesis" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "64857" "ENSG00000090924" "PLEKHG2" "B8ZZK6; C9J0Y4; hsa:64857; Q6DHV6; Q96BU2; Q96D18; Q9H699; Q9H7P9" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "Medium" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.014" "False" "1.782" "1" "1" "1" "1" "758" "83.6" "6.48" "2.85" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "" "Cristae formation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "Medium" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.014" "False" "1.782" "3" "1" "1" "1" "277" "32.0" "8.66" "3.35" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Genetic causes of porto-sinusoidal vascular disease" "Purine salvage" "2" "0" "1.007" "1.119" "1.151" "1.042" "1.164" "0.883" "1.041" "1.058" "1.073" "141.9" "142.9" "158.8" "163.3" "147.9" "165.2" "125.4" "147.7" "150.1" "152.3" "" "" "" "" "" "" "" "" "" "" "141.9" "120.9" "100.4" "119.1" "121.1" "128.3" "96.6" "127.0" "117.2" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8249329923731337218" "False" "Medium" "IsMasterProtein" "Q86U38" "Nucleolar protein 9 OS=Homo sapiens OX=9606 GN=NOP9 PE=1 SV=1" "0.014" "False" "1.781" "1" "1" "1" "1" "636" "69.4" "7.28" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "" "" "161424" "ENSG00000196943; ENSG00000285326" "NOP9" "A8MY76; hsa:161424; Q86U38; Q8IVF0; Q8TBS6" "" "" "0" "0" "1.179" "0.777" "0.995" "1.216" "0.838" "1.322" "1.369" "1.196" "0.889" "28.2" "33.2" "21.9" "28.1" "34.3" "23.6" "37.3" "38.6" "33.7" "25.1" "" "" "" "" "" "" "" "" "" "" "28.2" "28.1" "13.8" "20.5" "28.1" "18.3" "28.7" "33.2" "26.3" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "Medium" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.014" "False" "1.776" "0" "1" "1" "1" "3664" "402.0" "7.64" "2.93" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "Notch signaling pathway" "RHOBTB1 GTPase cycle" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7828527280741994957" "False" "Medium" "IsMasterProtein" "O75971" "snRNA-activating protein complex subunit 5 OS=Homo sapiens OX=9606 GN=SNAPC5 PE=1 SV=1" "0.014" "False" "1.776" "7" "1" "1" "1" "98" "11.3" "4.58" "2.38" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15497" "10302" "ENSG00000174446" "SNAPC5" "A8K7N6; hsa:10302; O75971; Q96CF3" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8926153379063192295" "False" "Medium" "IsMasterProtein" "C9J202" "Putative glycosyltransferase ALG1L2 OS=Homo sapiens OX=9606 GN=ALG1L2 PE=3 SV=1" "0.014" "False" "1.776" "4" "1" "1" "1" "215" "24.1" "5.76" "2.36" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00534" "644974" "ENSG00000251287" "ALG1L2" "C9J202; hsa:644974" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2814328454838082789" "False" "Medium" "IsMasterProtein" "Q6P087" "Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3" "0.014" "False" "1.774" "2" "1" "1" "1" "351" "38.4" "10.32" "2.90" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00849" "285367" "ENSG00000156990" "RPUSD3" "B4DS39; hsa:285367; Q6P087; Q6P6A9; Q8N1B2; Q8NAV3" "" "" "0" "0" "0.824" "0.996" "1.059" "0.979" "0.989" "0.908" "0.893" "1.104" "0.927" "55.4" "45.7" "55.2" "58.7" "54.2" "54.8" "50.3" "49.5" "61.2" "51.4" "" "" "" "" "" "" "" "" "" "" "55.4" "38.6" "34.9" "42.8" "44.4" "42.6" "38.8" "42.6" "47.8" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "Medium" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.015" "False" "1.763" "2" "1" "3" "1" "375" "41.4" "5.31" "1.83" "1" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7456705785760582485" "False" "Medium" "IsMasterProtein" "Q9BYJ4" "E3 ubiquitin-protein ligase TRIM34 OS=Homo sapiens OX=9606 GN=TRIM34 PE=1 SV=2" "0.015" "False" "1.761" "1" "1" "1" "1" "488" "56.8" "7.44" "2.54" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "53840" "ENSG00000258659" "TRIM34" "D3DQS7; hsa:53840; Q9BYJ4; Q9C016; Q9HCR0; Q9HCR1; Q9HCR2" "" "Interferon gamma signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "Medium" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.015" "False" "1.760" "4" "1" "1" "1" "378" "41.7" "5.78" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "Nephrotic syndrome; 15q25 copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322757000964109044" "False" "Medium" "IsMasterProtein" "A4D1F6" "Leucine-rich repeat and death domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRD1 PE=1 SV=2" "0.015" "False" "1.759" "1" "1" "1" "1" "860" "98.0" "7.46" "2.19" "1" "signal transduction" "" "" "Pf00560, Pf13855" "401387" "ENSG00000240720" "LRRD1" "A4D1F6; B7ZMM9; hsa:401387; Q49AT9" "" "" "0" "0" "1.153" "1.122" "1.069" "1.253" "1.113" "1.337" "1.299" "1.356" "1.262" "66.6" "76.8" "74.7" "71.2" "83.5" "74.1" "89.0" "86.5" "90.3" "84.0" "" "" "" "" "" "" "" "" "" "" "66.6" "65.0" "47.2" "51.9" "68.4" "57.6" "68.6" "74.4" "70.5" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2072306986524889695" "False" "Medium" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "0.016" "False" "1.758" "4" "1" "1" "1" "245" "28.2" "6.93" "2.15" "1" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.546" "0.934" "1.381" "1.487" "1.136" "1.209" "1.185" "1.142" "1.152" "35.0" "54.1" "32.7" "48.3" "52.0" "39.8" "42.3" "41.5" "40.0" "40.3" "" "" "" "" "" "" "" "" "" "" "35.0" "45.8" "20.7" "35.2" "42.6" "30.9" "32.6" "35.6" "31.2" "36.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5312560653861073020" "False" "Medium" "IsMasterProtein" "P82932" "Small ribosomal subunit protein bS6m OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "0.016" "False" "1.757" "6" "1" "1" "1" "125" "14.2" "9.26" "2.52" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "Medium" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.016" "False" "1.756" "3" "1" "1" "1" "259" "28.5" "8.43" "2.48" "1" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "334815564542611035" "False" "Medium" "IsMasterProtein" "Q9BTF0" "THUMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THUMPD2 PE=1 SV=2" "0.016" "False" "1.756" "2" "1" "1" "1" "503" "56.4" "7.81" "2.43" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "80745" "ENSG00000138050" "THUMPD2" "A8K7I7; hsa:80745; Q53TT8; Q53TV0; Q9BTF0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295020939105715533" "False" "Medium" "IsMasterProtein" "Q9NRS6" "Sorting nexin-15 OS=Homo sapiens OX=9606 GN=SNX15 PE=1 SV=1" "0.016" "False" "1.754" "4" "1" "1" "1" "342" "38.3" "5.19" "3.01" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00787, Pf04212" "29907" "ENSG00000110025" "SNX15" "E5KQS6; hsa:29907; Q9NRS5; Q9NRS6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6216659800236310345" "False" "Medium" "IsMasterProtein" "Q9H1Z4" "WD repeat-containing protein 13 OS=Homo sapiens OX=9606 GN=WDR13 PE=1 SV=3" "0.016" "False" "1.752" "3" "1" "1" "1" "485" "53.7" "9.23" "2.67" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus" "other molecular function" "Pf00400" "64743" "ENSG00000101940" "WDR13" "hsa:64743; Q06DW8; Q06DX0; Q06DX1; Q9BUL7; Q9H1Z4; Q9NWW4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5297574850053295946" "False" "Medium" "IsMasterProtein" "Q6NX49" "Zinc finger protein 544 OS=Homo sapiens OX=9606 GN=ZNF544 PE=1 SV=1" "0.016" "False" "1.750" "1" "1" "1" "1" "715" "81.7" "7.84" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "27300" "ENSG00000198131" "ZNF544" "A8K6J1; hsa:27300; Q6NX49; Q9UEX4" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187595421119904315" "False" "Medium" "IsMasterProtein" "Q96K31" "Uncharacterized protein C8orf76 OS=Homo sapiens OX=9606 GN=C8orf76 PE=1 SV=1" "0.016" "False" "1.748" "2" "1" "1" "1" "380" "43.2" "5.43" "1.86" "1" "" "" "" "Pf17826" "84933" "ENSG00000189376" "C8orf76" "hsa:84933; Q53HC1; Q96K31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6333685787667816615" "False" "Medium" "IsMasterProtein" "Q5T011" "KICSTOR complex protein SZT2 OS=Homo sapiens OX=9606 GN=SZT2 PE=1 SV=3" "0.016" "False" "1.746" "0" "1" "1" "1" "3432" "377.8" "6.27" "2.24" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "" "23334" "ENSG00000198198" "SZT2" "A0PJK5; A7E2X4; hsa:23334; O75055; Q5JUY7; Q5T011; Q5T012; Q5XKC7; Q6ZNI8; Q6ZT24; Q7Z636; Q8NAY9; Q9H5H7; Q9UFQ8" "" "Amino acids regulate mTORC1" "1" "0" "1.696" "0.964" "1.260" "1.137" "1.174" "1.147" "1.160" "0.878" "1.091" "15.1" "25.6" "14.5" "19.0" "17.1" "17.7" "17.3" "17.5" "13.2" "16.4" "" "" "" "" "" "" "" "" "" "" "15.1" "21.6" "9.2" "13.8" "14.0" "13.7" "13.3" "15.0" "10.3" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "Medium" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.016" "False" "1.735" "0" "1" "1" "1" "1960" "211.6" "9.04" "2.81" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "Matrix metalloproteinases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8247855334061398620" "False" "Medium" "IsMasterProtein" "Q9H4K7" "Mitochondrial ribosome-associated GTPase 2 OS=Homo sapiens OX=9606 GN=MTG2 PE=1 SV=1" "0.017" "False" "1.734" "2" "1" "1" "1" "406" "43.9" "9.45" "2.31" "1" "other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01018, Pf01926" "26164" "ENSG00000101181" "MTG2" "A6NDR3; B4DR85; hsa:26164; Q96I17; Q9H4K7; Q9NVG9; Q9UFR4" "" "" "0" "0" "1.272" "0.747" "1.209" "1.019" "0.748" "1.150" "1.035" "1.068" "1.097" "50.7" "64.5" "37.9" "61.3" "51.7" "38.0" "58.4" "52.5" "54.2" "55.7" "" "" "" "" "" "" "" "" "" "" "50.7" "54.6" "24.0" "44.7" "42.3" "29.5" "45.0" "45.1" "42.3" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797732752713602243" "False" "Medium" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "0.017" "False" "1.729" "2" "1" "1" "1" "365" "41.2" "10.70" "1.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-228772176721817864" "False" "Medium" "IsMasterProtein" "Q96HY6" "DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2" "0.017" "False" "1.726" "3" "1" "1" "1" "314" "35.6" "5.12" "2.22" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09756" "65992" "ENSG00000198171" "DDRGK1" "A6NIU5; C9JSZ5; hsa:65992; Q96HY6; Q9BW47" "" "RHOA GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3685684818087556165" "False" "Medium" "IsMasterProtein" "P49755" "Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2" "0.017" "False" "1.724" "3" "1" "1" "1" "219" "25.0" "7.44" "3.22" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01105" "10972" "ENSG00000170348" "TMED10" "B2R605; hsa:10972; P49755; Q15602; Q16536; Q86TC2; Q86TS5" "mRNA processing; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; Cargo concentration in the ER" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2884598250412237239" "False" "Medium" "IsMasterProtein" "Q9Y4D7" "Plexin-D1 OS=Homo sapiens OX=9606 GN=PLXND1 PE=1 SV=3" "0.017" "False" "1.723" "0" "1" "1" "1" "1925" "211.9" "7.15" "2.86" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf20170" "23129" "ENSG00000004399" "PLXND1" "A7E2C6; C9JPZ6; hsa:23129; Q6PJS9; Q8IZJ2; Q9BTQ2; Q9Y4D7" "Neurogenesis regulation in the olfactory epithelium" "NOTCH3 Intracellular Domain Regulates Transcription; RND2 GTPase cycle; Other semaphorin interactions" "4" "0" "1.162" "1.064" "1.099" "1.192" "1.215" "1.184" "1.189" "1.161" "1.161" "156.6" "182.1" "166.7" "172.2" "186.7" "190.3" "185.4" "186.3" "181.9" "181.8" "" "" "" "" "" "" "" "" "" "" "156.6" "154.0" "105.4" "125.5" "153.0" "147.7" "142.9" "160.2" "142.0" "163.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8147219015132361751" "False" "Medium" "IsMasterProtein" "Q96A19" "Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2" "0.017" "False" "1.721" "2" "1" "1" "1" "550" "62.6" "5.58" "3.07" "1" "" "cytoskeleton" "" "Pf01576" "92922" "ENSG00000135736" "CCDC102A" "hsa:92922; Q96A19; Q9BT74" "" "" "0" "0" "1.126" "1.336" "1.209" "1.143" "1.507" "1.328" "1.331" "1.135" "1.106" "58.5" "65.8" "78.1" "70.7" "66.8" "88.1" "77.6" "77.8" "66.4" "64.7" "" "" "" "" "" "" "" "" "" "" "58.5" "55.7" "49.4" "51.5" "54.8" "68.4" "59.8" "66.9" "51.8" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8604308957137322217" "False" "Medium" "IsMasterProtein" "Q8IXQ5" "Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2" "0.017" "False" "1.720" "2" "1" "1" "1" "586" "65.9" "6.48" "2.59" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55975" "ENSG00000122550" "KLHL7" "A4D144; B7Z5I9; G5E9G3; hsa:55975; Q7Z765; Q8IXQ5; Q96MV2; Q9BQF8; Q9UDQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5445595242509398747" "False" "Medium" "IsMasterProtein" "Q9UQL6" "Histone deacetylase 5 OS=Homo sapiens OX=9606 GN=HDAC5 PE=1 SV=2" "0.017" "False" "1.719" "1" "1" "1" "1" "1122" "121.9" "6.24" "1.98" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "10014" "ENSG00000108840" "HDAC5" "C9JFV9; hsa:10014; O60340; O60528; Q96DY4; Q9UQL6" "MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription" "14" "0" "1.324" "1.141" "1.350" "1.203" "0.991" "1.315" "1.334" "1.250" "1.138" "42.7" "56.6" "48.7" "57.7" "51.4" "42.4" "56.2" "57.0" "53.4" "48.6" "" "" "" "" "" "" "" "" "" "" "42.7" "47.9" "30.8" "42.1" "42.1" "32.9" "43.3" "49.0" "41.7" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8759036951300063870" "False" "Medium" "IsMasterProtein" "Q6ZT12" "E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens OX=9606 GN=UBR3 PE=1 SV=2" "0.017" "False" "1.715" "0" "1" "1" "1" "1888" "212.3" "6.10" "2.34" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf02207, Pf18995" "130507" "ENSG00000144357" "UBR3" "B4DZR7; Q2KHN5; Q6ZR55; Q6ZSC2; Q6ZT12; Q8IVE7; Q8ND96" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8162637103249760299" "False" "Medium" "IsMasterProtein" "Q14CB8" "Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1" "0.017" "False" "1.715" "2" "1" "1" "1" "494" "55.7" "9.36" "2.44" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "84986" "ENSG00000213390" "ARHGAP19" "A1XCP1; B4DZR1; hsa:84986; Q14CB8; Q14CF2; Q5J8M2; Q5T460; Q5T462; Q68DG6; Q8N9X1; Q8NF34; Q8TEK1" "" "RHOA GTPase cycle" "1" "0" "1.030" "0.689" "0.903" "0.915" "0.729" "1.073" "0.908" "0.651" "0.881" "93.5" "96.3" "64.4" "84.4" "85.6" "68.2" "100.3" "84.9" "60.9" "82.4" "" "" "" "" "" "" "" "" "" "" "93.5" "81.4" "40.8" "61.5" "70.1" "52.9" "77.3" "73.0" "47.5" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5021864284547303722" "False" "Medium" "IsMasterProtein" "Q96GD4" "Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3" "0.018" "False" "1.710" "2" "1" "1" "1" "344" "39.3" "9.29" "2.39" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9212" "ENSG00000178999" "AURKB" "B4DNM4; C7G533; C7G534; C7G535; D3DTR4; hsa:9212; J9JID1; O14630; O60446; O95083; Q96DV5; Q96GD4; Q9UQ46" "Microtubule cytoskeleton regulation; ATM signaling in development and disease" "Regulation of TP53 Activity through Phosphorylation; RHO GTPases Activate Formins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of MECP2 expression and activity; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "644829122365316147" "False" "Medium" "IsMasterProtein" "A5PLL1" "Ankyrin repeat domain-containing protein 34B OS=Homo sapiens OX=9606 GN=ANKRD34B PE=1 SV=3" "0.018" "False" "1.710" "2" "1" "1" "1" "514" "56.4" "7.71" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf12796, Pf13637" "340120" "ENSG00000189127" "ANKRD34B" "A5PLL1; B2RPH1; hsa:340120; Q68D79" "" "" "0" "0" "1.001" "1.224" "0.977" "1.095" "1.015" "1.001" "0.945" "1.116" "0.851" "162.3" "162.4" "198.6" "158.5" "177.7" "164.8" "162.4" "153.3" "181.1" "138.0" "" "" "" "" "" "" "" "" "" "" "162.3" "137.4" "125.6" "115.6" "145.6" "128.0" "125.2" "131.8" "141.3" "124.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256219212228257535" "False" "Medium" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "0.018" "False" "1.707" "2" "1" "1" "1" "373" "42.0" "6.89" "2.84" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "TNF-alpha signaling pathway; Amino acid metabolism; Cell lineage map for neuronal differentiation" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "5" "0" "1.022" "0.952" "1.034" "0.977" "0.971" "0.985" "1.076" "1.012" "1.002" "311.1" "317.9" "296.0" "321.7" "304.0" "302.0" "306.4" "334.6" "314.8" "311.8" "" "" "" "" "" "" "" "" "" "" "311.1" "268.9" "187.2" "234.5" "249.1" "234.5" "236.2" "287.7" "245.7" "280.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9221829543246918026" "False" "Medium" "IsMasterProtein" "P23763" "Vesicle-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=VAMP1 PE=1 SV=1" "0.018" "False" "1.701" "6" "1" "1" "1" "118" "12.9" "6.65" "2.85" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6843" "ENSG00000139190" "VAMP1" "A8MVP3; D3DUR3; hsa:6843; O75468; P23763; Q15857; Q6FG94; Q8IVC9" "" "Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "3" "0" "0.976" "1.108" "1.035" "1.032" "1.135" "1.185" "1.053" "0.843" "0.921" "74.9" "73.0" "82.9" "77.5" "77.3" "85.0" "88.7" "78.9" "63.1" "68.9" "" "" "" "" "" "" "" "" "" "" "74.9" "61.8" "52.4" "56.5" "63.3" "66.0" "68.4" "67.8" "49.3" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "Medium" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.018" "False" "1.697" "2" "1" "1" "1" "578" "63.7" "7.36" "2.10" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "" "Peroxisomal protein import; Alpha-oxidation of phytanate" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4456949863882440957" "False" "Medium" "IsMasterProtein" "Q86XH1" "Dynein regulatory complex protein 11 OS=Homo sapiens OX=9606 GN=IQCA1 PE=1 SV=1" "0.018" "False" "1.696" "1" "1" "1" "1" "822" "95.3" "9.47" "2.47" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf00004" "79781" "ENSG00000132321" "IQCA1" "B4DFH9; E7EWQ0; hsa:79781; Q4G164; Q53R37; Q53RV3; Q86XH1; Q96NS7; Q9H680" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908933075179858623" "False" "Medium" "IsMasterProtein" "Cont_A2I7N3" "Serpin A3-7 OS=Bos taurus OX=9913 GN=SERPINA3-7 PE=3 SV=1" "0.018" "True" "1.696" "2" "1" "1" "1" "417" "46.9" "6.34" "2.95" "1" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "" "" "SERPINA3-7" "A2I7N3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "Medium" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.018" "False" "1.693" "6" "1" "1" "1" "206" "23.6" "9.94" "2.12" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1762816792767039111" "False" "Medium" "IsMasterProtein" "Q9UJJ7" "RNA pseudouridylate synthase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RPUSD1 PE=1 SV=1" "0.019" "False" "1.687" "3" "1" "1" "1" "312" "34.7" "7.05" "2.46" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00849" "113000" "ENSG00000007376" "RPUSD1" "D3DU66; hsa:113000; Q9UJJ7" "" "" "0" "0" "0.942" "0.979" "1.177" "1.051" "0.753" "1.046" "1.111" "0.804" "1.018" "59.8" "56.3" "58.5" "70.4" "62.8" "45.0" "62.5" "66.4" "48.1" "60.9" "" "" "" "" "" "" "" "" "" "" "59.8" "47.6" "37.0" "51.3" "51.5" "34.9" "48.2" "57.1" "37.5" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "Medium" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.019" "False" "1.687" "1" "1" "1" "1" "1626" "183.2" "8.00" "2.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "" "SUMOylation of DNA replication proteins" "1" "0" "1.016" "2.076" "1.326" "0.529" "2.185" "1.333" "1.151" "2.230" "1.427" "11.8" "12.0" "24.5" "15.6" "6.2" "25.8" "15.7" "13.6" "26.3" "16.8" "" "" "" "" "" "" "" "" "" "" "11.8" "10.1" "15.5" "11.4" "5.1" "20.0" "12.1" "11.7" "20.5" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5283956025556149786" "False" "Medium" "IsMasterProtein" "Q6PIF6" "Unconventional myosin-VIIb OS=Homo sapiens OX=9606 GN=MYO7B PE=1 SV=2" "0.019" "False" "1.681" "0" "1" "1" "1" "2116" "241.4" "8.57" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00373, Pf00612, Pf00784, Pf07653" "4648" "ENSG00000169994" "MYO7B" "Q14786; Q6PIF6; Q8TEE1" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-4833474538863443704" "False" "Medium" "IsMasterProtein" "Q9NXZ2" "Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens OX=9606 GN=DDX43 PE=1 SV=2" "0.019" "False" "1.681" "2" "1" "1" "1" "648" "72.8" "8.75" "2.14" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00270, Pf00271" "55510" "ENSG00000080007" "DDX43" "B4E0C8; hsa:55510; Q6NXR1; Q9NXZ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3317416548883557326" "False" "Medium" "IsMasterProtein" "P00533" "Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2" "0.019" "False" "1.678" "1" "1" "1" "1" "1210" "134.2" "6.68" "2.62" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00757, Pf01030, Pf07714, Pf14843, Pf21314" "1956" "ENSG00000146648" "EGFR" "hsa:1956; O00688; O00732; P00533; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7; Q9UMD8; Q9UMG5" "Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q37 copy number variation syndrome; TROP2 regulatory signaling; TAR syndrome; NF1 copy number variation syndrome ; HDAC6 interactions in the central nervous system; ErbB signaling pathway" "HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; PIP3 activates AKT signaling; Respiratory syncytial virus (RSV) attachment and entry; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Cargo recognition for clathrin-mediated endocytosis; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants" "84" "0" "0.941" "1.095" "1.133" "1.107" "1.217" "1.101" "1.052" "1.116" "1.139" "106.5" "100.2" "116.6" "120.7" "117.9" "129.6" "117.3" "112.1" "118.9" "121.4" "" "" "" "" "" "" "" "" "" "" "106.5" "84.8" "73.8" "88.0" "96.6" "100.7" "90.4" "96.4" "92.8" "109.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "Medium" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.019" "False" "1.674" "1" "1" "1" "1" "1016" "108.0" "8.28" "3.00" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7114362037868025430" "False" "Medium" "IsMasterProtein" "Q5THK1" "Protein PRR14L OS=Homo sapiens OX=9606 GN=PRR14L PE=1 SV=1" "0.019" "False" "1.672" "0" "1" "1" "1" "2151" "237.2" "6.33" "1.95" "1" "" "" "" "Pf15386" "253143" "ENSG00000183530" "PRR14L" "hsa:253143; Q5THK1; Q5THK4; Q6ZNN1; Q6ZWH0; Q8IW74; Q9H5T4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265371385321756616" "False" "Medium" "IsMasterProtein" "P0C671" "Protein BNIP5 OS=Homo sapiens OX=9606 GN=BNIP5 PE=1 SV=1" "0.020" "False" "1.670" "2" "1" "2" "1" "652" "71.9" "8.47" "4.75" "1" "" "" "" "Pf15661" "389384" "ENSG00000189325" "BNIP5" "B2RTY8; P0C671" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "Medium" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.020" "False" "1.668" "4" "1" "1" "1" "312" "32.8" "7.81" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9041670959328439504" "False" "Medium" "IsMasterProtein" "Q13487" "snRNA-activating protein complex subunit 2 OS=Homo sapiens OX=9606 GN=SNAPC2 PE=1 SV=1" "0.020" "False" "1.668" "3" "1" "1" "1" "334" "35.5" "6.01" "2.53" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf11035" "6618" "ENSG00000104976" "SNAPC2" "B2RBZ6; D6W663; hsa:6618; Q13486; Q13487" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3754382258737944185" "False" "Medium" "IsMasterProtein" "Q9Y546" "Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1" "0.020" "False" "1.667" "2" "1" "1" "1" "428" "48.5" "7.46" "2.21" "1" "" "" "" "Pf13516" "115353" "ENSG00000116212" "LRRC42" "D3DQ46; hsa:115353; Q8N2Q8; Q9Y546" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5567467987070279927" "False" "Medium" "IsMasterProtein" "Q96CV9" "Optineurin OS=Homo sapiens OX=9606 GN=OPTN PE=1 SV=3" "0.020" "False" "1.661" "2" "1" "1" "1" "577" "65.9" "5.17" "1.97" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11577, Pf16516, Pf18414" "10133" "ENSG00000123240" "OPTN" "B3KP00; D3DRS4; D3DRS8; hsa:10133; Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q96CV9; Q9UET9; Q9UEV4; Q9Y218" "HDAC6 interactions in the central nervous system" "Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PLK1 Activity at G2/M Transition; TNFR1-induced NF-kappa-B signaling pathway; TBC/RABGAPs" "6" "0" "1.156" "0.609" "1.478" "1.253" "1.156" "1.030" "1.210" "1.254" "0.749" "11.8" "13.6" "7.2" "17.4" "14.7" "13.6" "12.1" "14.2" "14.8" "8.8" "" "" "" "" "" "" "" "" "" "" "11.8" "11.5" "4.5" "12.7" "12.1" "10.6" "9.3" "12.2" "11.5" "7.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8617908927917494365" "False" "Medium" "IsMasterProtein" "O14639" "Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1 PE=1 SV=3" "0.020" "False" "1.661" "1" "1" "1" "1" "778" "87.6" "8.59" "2.87" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "3983" "ENSG00000099204" "ABLIM1" "A6NI16; A6NJ06; A8MXA9; B3KVH2; hsa:3983; O14639; Q15039; Q5JVV1; Q5JVV2; Q5T6N2; Q5T6N3; Q5T6N5; Q68CQ9; Q9BUP1" "Male infertility" "DCC mediated attractive signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256135523585103311" "False" "Medium" "IsMasterProtein" "Q86XL3" "Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4" "0.021" "False" "1.657" "1" "1" "1" "1" "938" "104.1" "7.09" "1.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00023, Pf01693, Pf03020" "23141" "ENSG00000176915" "ANKLE2" "A8KAG3; B3KN97; B3KSF8; hsa:23141; O75176; Q6P6A5; Q86XL3; Q8TAZ9; Q96DH4" "" "RHOG GTPase cycle; RAC2 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "2126851971965856372" "False" "Medium" "IsMasterProtein" "Q9BSU1" "Phagosome assembly factor 1 OS=Homo sapiens OX=9606 GN=PHAF1 PE=1 SV=1" "0.021" "False" "1.648" "2" "1" "1" "1" "422" "47.5" "7.72" "1.90" "1" "transport" "other membranes;ER/Golgi;other cell component" "" "Pf03676" "80262" "ENSG00000125149" "PHAF1" "hsa:80262; Q9BSU1; Q9HA86" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531745898464633118" "False" "Medium" "IsMasterProtein" "Q6P3S6" "F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1" "0.021" "False" "1.647" "2" "1" "1" "1" "717" "77.8" "7.43" "3.04" "1" "" "other cell component" "other molecular function" "Pf12937, Pf13415, Pf13854" "54455" "ENSG00000037637; ENSG00000291375" "FBXO42" "B3KP30; hsa:54455; Q5TEU8; Q6P3S6; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4" "" "" "0" "0" "0.969" "0.903" "1.089" "1.166" "1.038" "1.143" "1.178" "1.077" "0.886" "39.3" "38.1" "35.5" "42.8" "45.8" "40.8" "44.9" "46.3" "42.3" "34.8" "" "" "" "" "" "" "" "" "" "" "39.3" "32.2" "22.4" "31.2" "37.5" "31.7" "34.6" "39.8" "33.0" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "Medium" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.021" "False" "1.646" "1" "1" "1" "1" "773" "86.0" "5.95" "2.97" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8775009623055408679" "False" "Medium" "IsMasterProtein" "Q5BKY9" "Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1" "0.021" "False" "1.643" "4" "1" "1" "1" "247" "28.4" "10.02" "2.27" "1" "" "" "" "" "257415" "ENSG00000234545" "FAM133B" "B2R994; hsa:257415; Q05D67; Q5BKY9; Q6P5S6; Q8N0W8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2680076105729962099" "False" "Medium" "IsMasterProtein" "Q8NCM8" "Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC2H1 PE=1 SV=4" "0.020" "False" "1.637" "0" "1" "1" "1" "4307" "492.3" "6.54" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf18198, Pf18199, Pf21264" "79659" "ENSG00000187240" "DYNC2H1" "hsa:79659; O00432; Q16693; Q3C1U8; Q4AC93; Q6ZMX7; Q6ZUM6; Q7Z363; Q8N977; Q8NCM8; Q92815; Q9HAE4" "Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption; Bardet-Biedl syndrome" "Intraflagellar transport; Hedgehog 'off' state" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660821909293433044" "False" "Medium" "IsMasterProtein" "Q9NRW4" "Dual specificity protein phosphatase 22 OS=Homo sapiens OX=9606 GN=DUSP22 PE=1 SV=1" "0.020" "False" "1.634" "8" "1" "1" "1" "184" "20.9" "8.10" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00782" "56940" "ENSG00000112679" "DUSP22" "B4DK56; hsa:56940; Q59GW2; Q5VWR2; Q96AR1; Q9NRW4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "Medium" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.020" "False" "1.633" "2" "1" "1" "1" "438" "48.1" "8.06" "2.87" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Fatty acid beta-oxidation; Tryptophan metabolism" "Lysine catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6594093010420554285" "False" "Medium" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.021" "False" "1.630" "2" "1" "1" "1" "460" "51.5" "5.41" "2.66" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "23" "0" "0.920" "1.087" "1.124" "0.966" "0.804" "1.010" "1.007" "0.782" "0.873" "62.8" "57.8" "68.3" "70.6" "60.7" "50.5" "63.5" "63.3" "49.1" "54.9" "" "" "" "" "" "" "" "" "" "" "62.8" "48.9" "43.2" "51.5" "49.7" "39.2" "48.9" "54.4" "38.3" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "Medium" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.021" "False" "1.626" "3" "1" "1" "1" "494" "54.6" "7.23" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "Medium" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.021" "False" "1.625" "1" "1" "1" "1" "770" "86.8" "6.67" "3.29" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1066675422461662542" "False" "Medium" "IsMasterProtein" "Q8WVE0" "EEF1A lysine methyltransferase 1 OS=Homo sapiens OX=9606 GN=EEF1AKMT1 PE=1 SV=1" "0.023" "False" "1.612" "5" "1" "1" "1" "214" "24.5" "4.55" "2.30" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf10237" "221143" "ENSG00000150456" "EEF1AKMT1" "B5G4V1; hsa:221143; Q8WVE0" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3784875960281055954" "False" "Medium" "IsMasterProtein" "O00311" "Cell division cycle 7-related protein kinase OS=Homo sapiens OX=9606 GN=CDC7 PE=1 SV=1" "0.023" "False" "1.611" "2" "1" "1" "1" "574" "63.8" "8.73" "2.91" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8317" "ENSG00000097046" "CDC7" "D3DT31; hsa:8317; O00311; O00558; Q5T5U5" "Cell cycle; Retinoblastoma gene in cancer; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7669461572813091295" "False" "Medium" "IsMasterProtein" "Q5D0E6" "DALR anticodon-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=DALRD3 PE=1 SV=2" "0.022" "False" "1.610" "2" "1" "1" "1" "543" "59.3" "7.42" "1.83" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf05746" "55152" "ENSG00000178149" "DALRD3" "hsa:55152; Q5D0E6; Q7Z5S7; Q86WY1; Q8N105; Q8NA89; Q9NVU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "Medium" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.022" "False" "1.610" "3" "1" "1" "1" "260" "29.4" "5.21" "2.72" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Allograft rejection; Ebola virus infection in host" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "9" "0" "0.807" "1.357" "1.135" "1.026" "1.272" "1.041" "1.091" "1.202" "1.053" "90.8" "73.3" "123.3" "103.1" "93.1" "115.5" "94.5" "99.1" "109.1" "95.6" "" "" "" "" "" "" "" "" "" "" "90.8" "62.0" "77.9" "75.2" "76.3" "89.7" "72.9" "85.2" "85.2" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7915225463395773870" "False" "Medium" "IsMasterProtein" "Q9NS39" "Double-stranded RNA-specific editase B2 OS=Homo sapiens OX=9606 GN=ADARB2 PE=1 SV=1" "0.023" "False" "1.610" "1" "1" "1" "1" "739" "80.6" "10.17" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137" "105" "ENSG00000185736" "ADARB2" "B2RPJ5; hsa:105; Q5VUT6; Q5VW42; Q9NS39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3271098639454742173" "False" "Medium" "IsMasterProtein" "Q9H9B4" "Sideroflexin-1 OS=Homo sapiens OX=9606 GN=SFXN1 PE=1 SV=4" "0.023" "False" "1.608" "3" "1" "1" "1" "322" "35.6" "9.07" "2.79" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf03820" "94081" "ENSG00000164466" "SFXN1" "B3KPW3; D3DQN2; hsa:94081; Q9H9B4; Q9HA53" "Metabolic Epileptic Disorders" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5225742282828706661" "False" "Medium" "IsMasterProtein" "Q8NDH2" "Leucine-rich repeat transmembrane protein CCDC168 OS=Homo sapiens OX=9606 GN=CCDC168 PE=1 SV=3" "0.024" "False" "1.584" "0" "1" "1" "1" "7081" "801.4" "8.79" "0.00" "1" "" "other membranes" "" "Pf15804" "643677" "ENSG00000175820" "CCDC168" "hsa:643677; Q8N800; Q8NDH2" "" "" "0" "0" "1.159" "1.257" "1.068" "0.977" "1.208" "1.066" "0.926" "1.545" "1.012" "18.7" "21.6" "23.5" "20.0" "18.2" "22.6" "19.9" "17.3" "28.9" "18.9" "" "" "" "" "" "" "" "" "" "" "18.7" "18.3" "14.8" "14.6" "14.9" "17.5" "15.3" "14.9" "22.5" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "Medium" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.024" "False" "1.580" "1" "1" "1" "1" "894" "103.7" "8.65" "2.82" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.178" "1.005" "1.109" "1.080" "1.061" "1.199" "1.080" "1.079" "1.099" "103.2" "121.5" "103.7" "114.4" "111.4" "109.5" "123.7" "111.4" "111.3" "113.5" "" "" "" "" "" "" "" "" "" "" "103.2" "102.8" "65.6" "83.4" "91.3" "85.1" "95.4" "95.8" "86.9" "102.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6450770185944886404" "False" "Medium" "IsMasterProtein" "Q504Q3" "PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Homo sapiens OX=9606 GN=PAN2 PE=1 SV=3" "0.024" "False" "1.580" "1" "1" "1" "1" "1202" "135.3" "5.99" "2.17" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929, Pf13423, Pf20770" "9924" "ENSG00000135473" "PAN2" "hsa:9924; O75189; Q504Q3; Q76E12; Q8IVE1" "Ectoderm differentiation; Ectoderm differentiation" "Deadenylation of mRNA" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-419593273491942870" "False" "Medium" "IsMasterProtein" "P0C7P3" "Protein SLFN14 OS=Homo sapiens OX=9606 GN=SLFN14 PE=1 SV=2" "0.024" "False" "1.579" "1" "1" "2" "1" "912" "103.8" "8.24" "4.34" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04326, Pf17057, Pf21026" "342618" "ENSG00000236320" "SLFN14" "B2RTW9; hsa:342618; P0C7P3" "17q12 copy number variation syndrome" "" "1" "0" "1.124" "0.973" "0.933" "1.014" "0.954" "1.020" "1.083" "1.048" "0.872" "73.9" "83.1" "71.9" "69.0" "74.9" "70.5" "75.4" "80.1" "77.5" "64.4" "" "" "" "" "" "" "" "" "" "" "73.9" "70.3" "45.5" "50.3" "61.4" "54.8" "58.1" "68.9" "60.5" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4333754145708475207" "False" "Medium" "IsMasterProtein" "Q9UKT8" "F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2" "0.024" "False" "1.578" "2" "1" "1" "1" "454" "51.5" "6.58" "2.73" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00400, Pf00646" "26190" "ENSG00000119402" "FBXW2" "B3KRL8; hsa:26190; Q4VXH2; Q7Z4V6; Q8WV51; Q9HA09; Q9UKA3; Q9UKT8" "Wnt signaling pathway and pluripotency" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4063662808380045850" "False" "Medium" "IsMasterProtein" "Q6DKI1" "Ribosomal protein uL30-like OS=Homo sapiens OX=9606 GN=RPL7L1 PE=1 SV=2" "0.024" "False" "1.575" "4" "1" "1" "1" "255" "29.7" "10.52" "2.52" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf00327, Pf08079" "285855" "ENSG00000146223" "RPL7L1" "A8K7D4; B7Z652; hsa:285855; Q5TFZ5; Q6DKI1; Q6PEK3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785524813624673912" "False" "Medium" "IsMasterProtein" "P19086" "Guanine nucleotide-binding protein G(z) subunit alpha OS=Homo sapiens OX=9606 GN=GNAZ PE=1 SV=3" "0.024" "False" "1.573" "2" "1" "1" "1" "355" "40.9" "7.61" "2.26" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2781" "ENSG00000128266" "GNAZ" "B2R6C1; P19086; Q4QRJ6" "Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "10" "0" "0.988" "0.802" "0.975" "1.180" "1.046" "1.139" "1.021" "0.868" "0.964" "69.9" "69.1" "56.0" "68.2" "82.5" "73.1" "79.6" "71.4" "60.7" "67.4" "" "" "" "" "" "" "" "" "" "" "69.9" "58.5" "35.4" "49.7" "67.6" "56.8" "61.4" "61.4" "47.4" "60.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "Medium" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.024" "False" "1.572" "2" "1" "1" "1" "505" "54.5" "7.88" "2.19" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "Medium" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.024" "False" "1.572" "3" "1" "1" "1" "234" "26.2" "5.49" "2.08" "1" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7572022130176331113" "False" "Medium" "IsMasterProtein" "Q9H840" "Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1" "0.024" "False" "1.571" "5" "1" "1" "1" "131" "14.5" "7.40" "2.84" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf11095" "79760" "ENSG00000142252" "GEMIN7" "hsa:79760; Q6IA34; Q9H840" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "1.103" "0.888" "1.105" "1.065" "0.981" "1.135" "1.104" "0.974" "0.949" "154.7" "170.7" "137.5" "171.0" "164.8" "151.8" "175.6" "170.8" "150.7" "146.8" "" "" "" "" "" "" "" "" "" "" "154.7" "144.4" "86.9" "124.7" "135.0" "117.9" "135.3" "146.8" "117.6" "132.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "Medium" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.024" "False" "1.571" "2" "1" "1" "1" "349" "39.3" "7.52" "3.38" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8053733980906491982" "False" "Medium" "IsMasterProtein" "P40200" "T-cell surface protein tactile OS=Homo sapiens OX=9606 GN=CD96 PE=1 SV=2" "0.024" "False" "1.568" "1" "1" "1" "1" "585" "65.6" "7.12" "2.33" "1" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "10225" "ENSG00000153283" "CD96" "hsa:10225; P40200; Q5JPB3" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7269919126570467546" "False" "Medium" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "0.024" "False" "1.568" "5" "1" "1" "1" "161" "17.9" "7.99" "2.60" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "Eukaryotic transcription initiation" "HATs acetylate histones; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "1.066" "1.215" "0.960" "1.375" "1.167" "1.568" "1.509" "1.048" "1.450" "21.2" "22.6" "25.7" "20.4" "29.1" "24.7" "33.2" "32.0" "22.2" "30.7" "" "" "" "" "" "" "" "" "" "" "21.2" "19.1" "16.3" "14.8" "23.9" "19.2" "25.6" "27.5" "17.3" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2432573518127271622" "False" "Medium" "IsMasterProtein" "Q6UUV7" "CREB-regulated transcription coactivator 3 OS=Homo sapiens OX=9606 GN=CRTC3 PE=1 SV=2" "0.024" "False" "1.568" "1" "1" "1" "1" "619" "66.9" "6.84" "2.35" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "64784" "ENSG00000140577" "CRTC3" "hsa:64784; Q6DK61; Q6DK62; Q6UUV7; Q8NF38; Q9H6U2" "" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "3" "0" "1.171" "1.184" "1.007" "0.950" "1.153" "0.764" "1.071" "1.429" "1.064" "26.8" "31.4" "31.7" "27.0" "25.4" "30.9" "20.4" "28.7" "38.3" "28.5" "" "" "" "" "" "" "" "" "" "" "26.8" "26.5" "20.0" "19.7" "20.8" "24.0" "15.8" "24.7" "29.9" "25.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3685516950624911126" "False" "Medium" "IsMasterProtein" "Q5TGL8" "PX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PXDC1 PE=1 SV=3" "0.024" "False" "1.561" "10" "1" "2" "1" "231" "26.5" "5.03" "2.11" "1" "" "" "other molecular function" "" "221749" "ENSG00000168994" "PXDC1" "A8K0N3; hsa:221749; Q5TGL8; Q6PGP0; Q86XB7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "362946439677958782" "False" "Medium" "IsMasterProtein" "Q9Y679" "Lipid droplet-regulating VLDL assembly factor AUP1 OS=Homo sapiens OX=9606 GN=AUP1 PE=1 SV=2" "0.024" "False" "1.561" "2" "1" "1" "1" "410" "45.8" "8.65" "3.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "550" "ENSG00000115307" "AUP1" "C0H5W8; hsa:550; Q9H866; Q9UNQ6; Q9Y679; Q9Y685" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "Medium" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.024" "False" "1.560" "0" "1" "1" "1" "1901" "210.4" "5.39" "2.49" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "G protein signaling pathways" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1233208040052068453" "False" "Medium" "IsMasterProtein" "Q5T2R2" "All trans-polyprenyl-diphosphate synthase PDSS1 OS=Homo sapiens OX=9606 GN=PDSS1 PE=1 SV=1" "0.024" "False" "1.559" "2" "1" "1" "1" "415" "46.2" "9.00" "3.08" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00348" "23590" "ENSG00000148459" "PDSS1" "hsa:23590; Q53F75; Q5T2R2; Q6P473; Q86WQ8; Q9Y2W5" "" "Ubiquinol biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "975023732252916358" "False" "Medium" "IsMasterProtein" "P42081" "T-lymphocyte activation antigen CD86 OS=Homo sapiens OX=9606 GN=CD86 PE=1 SV=2" "0.024" "False" "1.558" "3" "1" "1" "1" "329" "37.7" "6.92" "0.00" "1" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton" "signal transduction activity or receptor binding;other molecular function" "Pf07686" "942" "ENSG00000114013" "CD86" "A0N0P0; B7Z2F3; B7Z702; E7ETN5; E9PC27; hsa:942; P42081; Q13655; Q6FHB1; Q6GTS4; Q7M4L5" "Allograft rejection; IL-3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Macrophage markers; Control of immune tolerance by vasoactive intestinal peptide; Inflammatory response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Cancer immunotherapy by CTLA4 blockade; Cell interactions of the pancreatic cancer microenvironment; Toll-like receptor signaling pathway" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interleukin-10 signaling; CD28 dependent PI3K/Akt signaling; CTLA4 inhibitory signaling; CD28 dependent Vav1 pathway" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463522735319849849" "False" "Medium" "IsMasterProtein" "O15031" "Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3" "0.025" "False" "1.553" "0" "1" "1" "1" "1838" "205.0" "6.24" "2.06" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf20170" "23654" "ENSG00000196576" "PLXNB2" "A6QRH0; hsa:23654; O15031; Q7KZU3; Q9BSU7" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2917798265732116081" "False" "Medium" "IsMasterProtein" "Q8NI38" "NF-kappa-B inhibitor delta OS=Homo sapiens OX=9606 GN=NFKBID PE=1 SV=1" "0.026" "False" "1.547" "2" "1" "1" "1" "313" "33.5" "7.43" "2.40" "1" "stress response;signal transduction;other biological processes" "nucleus" "" "Pf12796, Pf13857" "84807" "ENSG00000167604" "NFKBID" "hsa:84807; Q8NI38; Q8NI39; Q9BRG9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124474899174263242" "False" "Medium" "IsMasterProtein" "Q08AF3" "Schlafen family member 5 OS=Homo sapiens OX=9606 GN=SLFN5 PE=1 SV=1" "0.026" "False" "1.546" "1" "1" "1" "1" "891" "101.0" "8.22" "2.28" "1" "other biological processes" "nucleus" "other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "162394" "ENSG00000166750" "SLFN5" "hsa:162394; Q08AF2; Q08AF3; Q8WU54; Q96A82" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300831258650065566" "False" "Medium" "IsMasterProtein" "Q9P281" "BAH and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BAHCC1 PE=1 SV=4" "0.026" "False" "1.544" "0" "1" "1" "1" "2639" "279.8" "8.78" "3.36" "1" "" "" "other molecular function" "Pf01426, Pf21744" "57597" "ENSG00000266074" "BAHCC1" "A0A075B747; hsa:57597; Q5U629; Q9P281" "" "" "0" "0" "1.190" "1.352" "1.416" "1.263" "1.314" "1.309" "1.265" "1.276" "1.204" "75.6" "90.0" "102.2" "107.1" "95.5" "99.3" "99.0" "95.7" "96.5" "91.0" "" "" "" "" "" "" "" "" "" "" "75.6" "76.1" "64.6" "78.1" "78.2" "77.1" "76.3" "82.2" "75.3" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5668169265399271149" "False" "Medium" "IsMasterProtein" "Q8N9N5" "Protein BANP OS=Homo sapiens OX=9606 GN=BANP PE=1 SV=3" "0.026" "False" "1.543" "1" "1" "1" "1" "519" "56.5" "5.49" "2.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf10523" "54971" "ENSG00000172530" "BANP" "A8MU25; A8MX25; B2RCF7; B4DNJ9; F5GZM0; hsa:54971; Q8N9N5; Q96GJ7; Q9NWY1" "" "Regulation of TP53 Activity through Association with Co-factors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927192011377040522" "False" "Medium" "IsMasterProtein" "Q2NL68" "Proline and serine-rich protein 3 OS=Homo sapiens OX=9606 GN=PROSER3 PE=1 SV=1" "0.026" "False" "1.541" "2" "1" "3" "1" "480" "51.0" "7.14" "4.76" "1" "" "cytoskeleton;other cell component" "" "" "148137" "ENSG00000167595" "PROSER3" "hsa:148137; Q2NL68; Q8NDI3; Q8WWC8; Q96NL4" "" "" "0" "0" "0.906" "1.235" "1.194" "1.146" "1.256" "1.176" "1.245" "1.164" "1.212" "79.6" "72.1" "98.4" "95.1" "91.3" "100.0" "93.7" "99.1" "92.7" "96.5" "" "" "" "" "" "" "" "" "" "" "79.6" "61.0" "62.2" "69.4" "74.8" "77.7" "72.2" "85.2" "72.3" "86.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558457419742153856" "False" "Medium" "IsMasterProtein" "P53567" "CCAAT/enhancer-binding protein gamma OS=Homo sapiens OX=9606 GN=CEBPG PE=1 SV=1" "0.027" "False" "1.534" "5" "1" "1" "1" "150" "16.4" "9.77" "2.50" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1054" "ENSG00000153879" "CEBPG" "B2R946; hsa:1054; P53567; Q5U052" "Differentiation of white and brown adipocyte; Transcriptional cascade regulating adipogenesis" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "Medium" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.028" "False" "1.531" "5" "1" "2" "1" "153" "16.3" "9.83" "2.45" "1" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "15q25 copy number variation" "" "1" "0" "0.899" "1.023" "0.984" "1.094" "0.998" "1.135" "1.188" "1.204" "1.107" "79.3" "71.3" "81.2" "78.0" "86.8" "79.2" "90.1" "94.2" "95.5" "87.8" "" "" "" "" "" "" "" "" "" "" "79.3" "60.3" "51.3" "56.9" "71.1" "61.5" "69.4" "81.0" "74.6" "79.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "813954222595635444" "False" "Medium" "IsMasterProtein" "Q9H668" "CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2" "0.028" "False" "1.530" "3" "1" "1" "1" "368" "42.1" "6.07" "2.63" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf01336, Pf09170" "79991" "ENSG00000107960" "STN1" "D3DR99; hsa:79991; Q5TCZ0; Q9H668" "Lung fibrosis" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation" "3" "0" "0.918" "0.983" "0.922" "1.008" "0.858" "1.027" "1.012" "1.103" "1.039" "112.9" "103.7" "111.1" "104.1" "113.9" "96.9" "115.9" "114.3" "124.6" "117.4" "" "" "" "" "" "" "" "" "" "" "112.9" "87.7" "70.2" "75.9" "93.3" "75.2" "89.4" "98.3" "97.2" "105.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652063056633213151" "False" "Medium" "IsMasterProtein" "Q9Y4C4" "Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2" "0.028" "False" "1.524" "1" "1" "2" "1" "1052" "116.9" "7.88" "4.98" "1" "stress response;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13855" "9258" "ENSG00000147324" "MFHAS1" "hsa:9258; Q96CI0; Q9Y4C4" "8p23.1 copy number variation syndrome" "" "1" "0" "1.071" "0.899" "0.976" "1.088" "0.870" "1.043" "1.008" "0.865" "0.962" "93.9" "100.6" "84.4" "91.7" "102.2" "81.7" "98.0" "94.7" "81.3" "90.3" "" "" "" "" "" "" "" "" "" "" "93.9" "85.1" "53.4" "66.9" "83.7" "63.5" "75.5" "81.4" "63.5" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "Medium" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.028" "False" "1.523" "1" "1" "2" "1" "745" "82.3" "5.40" "4.30" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.047" "1.014" "1.209" "1.182" "1.064" "1.142" "1.006" "1.078" "1.154" "150.0" "157.1" "152.1" "181.3" "177.3" "159.6" "171.2" "150.9" "161.7" "173.1" "" "" "" "" "" "" "" "" "" "" "150.0" "132.9" "96.2" "132.2" "145.3" "123.9" "132.0" "129.7" "126.2" "155.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "Medium" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.028" "False" "1.521" "1" "1" "1" "1" "794" "88.9" "6.48" "0.00" "1" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "Not Found" "High" "1" "" "-6407451735781727026" "False" "Medium" "IsMasterProtein" "Q8N5S1" "Mitochondrial carrier protein SCaMC-3L OS=Homo sapiens OX=9606 GN=SLC25A41 PE=1 SV=2" "0.028" "False" "1.521" "4" "1" "1" "1" "370" "40.8" "9.22" "1.87" "1" "transport" "other membranes;mitochondrion" "transporter activity" "Pf00153" "284427" "ENSG00000181240" "SLC25A41" "A8MQ40; D6W642; hsa:284427; Q8N5S1; Q8N7R4" "" "" "0" "0" "1.107" "1.222" "1.220" "1.356" "1.207" "1.005" "1.142" "1.253" "1.230" "37.8" "41.8" "46.2" "46.1" "51.3" "45.6" "38.0" "43.2" "47.3" "46.5" "" "" "" "" "" "" "" "" "" "" "37.8" "35.4" "29.2" "33.6" "42.0" "35.4" "29.3" "37.1" "37.0" "41.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3192969394575095847" "False" "Medium" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.029" "False" "1.516" "2" "1" "1" "1" "334" "37.2" "9.47" "2.59" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "Medium" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.029" "False" "1.512" "2" "1" "1" "1" "383" "43.5" "5.81" "2.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "5q35 copy number variation" "Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; G2/M DNA damage checkpoint" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "Medium" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.029" "False" "1.510" "2" "1" "1" "1" "300" "34.8" "6.14" "2.51" "1" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "4" "0" "0.932" "1.123" "1.014" "0.854" "0.927" "0.872" "0.904" "0.971" "0.958" "33.6" "31.3" "37.7" "34.0" "28.7" "31.1" "29.3" "30.3" "32.6" "32.1" "" "" "" "" "" "" "" "" "" "" "33.6" "26.5" "23.8" "24.8" "23.5" "24.2" "22.6" "26.1" "25.4" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2555590194794136668" "False" "Medium" "IsMasterProtein" "Q9C073" "Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1" "0.029" "False" "1.508" "2" "1" "1" "1" "453" "48.3" "8.31" "2.13" "1" "" "" "" "Pf15388" "81558" "ENSG00000121104" "FAM117A" "B7Z7Q3; hsa:81558; Q9C073" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "Medium" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.029" "False" "1.500" "2" "1" "1" "1" "508" "59.3" "10.39" "2.16" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "mRNA processing" "" "1" "0" "1.163" "0.947" "1.190" "0.933" "1.103" "1.327" "0.888" "1.052" "0.918" "60.6" "70.5" "57.4" "72.2" "56.6" "66.8" "80.5" "53.9" "63.8" "55.7" "" "" "" "" "" "" "" "" "" "" "60.6" "59.7" "36.3" "52.6" "46.4" "51.9" "62.0" "46.3" "49.8" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566997630735090852" "False" "Medium" "IsMasterProtein" "Q8NHU6" "Tudor domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TDRD7 PE=1 SV=2" "0.029" "False" "1.493" "1" "1" "1" "1" "1098" "123.5" "7.21" "3.40" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00567, Pf12872" "23424" "ENSG00000196116" "TDRD7" "A6NCI6; B2RBX3; B4DG99; B4DXF7; E7EQD4; hsa:23424; Q5VV27; Q8NHU6; Q96JT1; Q9UFF0; Q9Y2M3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4276327742936350895" "False" "Medium" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "0.029" "False" "1.487" "1" "1" "1" "1" "1327" "149.5" "8.16" "2.51" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "Medium" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.029" "False" "1.484" "4" "1" "1" "1" "248" "28.1" "6.90" "2.24" "1" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "1.138" "0.852" "0.959" "1.089" "0.955" "1.082" "1.086" "0.929" "1.132" "56.1" "63.9" "47.8" "53.8" "61.1" "53.6" "60.7" "60.9" "52.1" "63.5" "" "" "" "" "" "" "" "" "" "" "56.1" "54.0" "30.2" "39.2" "50.1" "41.6" "46.8" "52.4" "40.7" "57.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "Medium" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.029" "False" "1.483" "4" "1" "1" "1" "160" "19.0" "5.20" "2.42" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "Medium" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.029" "False" "1.481" "5" "1" "1" "1" "145" "16.3" "8.60" "2.60" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "3" "0" "1.140" "1.028" "1.132" "1.171" "1.185" "1.251" "1.148" "1.064" "1.082" "75.6" "86.2" "77.8" "85.6" "88.6" "89.6" "94.7" "86.8" "80.5" "81.9" "" "" "" "" "" "" "" "" "" "" "75.6" "73.0" "49.2" "62.4" "72.6" "69.6" "73.0" "74.7" "62.8" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1620287855834413498" "False" "Medium" "IsMasterProtein" "Q86XE3" "Calcium uptake protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=MICU3 PE=1 SV=1" "0.029" "False" "1.481" "2" "1" "1" "1" "530" "60.7" "8.21" "2.92" "1" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13499" "286097" "ENSG00000155970" "MICU3" "hsa:286097; Q86XE3; Q8IYZ3" "" "Processing of SMDT1" "2" "0" "0.986" "1.059" "1.040" "1.079" "1.074" "1.025" "1.005" "0.956" "1.035" "176.9" "174.5" "187.4" "183.9" "190.9" "190.1" "181.3" "177.9" "169.1" "183.2" "" "" "" "" "" "" "" "" "" "" "176.9" "147.6" "118.5" "134.1" "156.4" "147.6" "139.7" "152.9" "132.0" "164.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6472218816476808193" "False" "Medium" "IsMasterProtein" "Q5TCZ1" "SH3 and PX domain-containing protein 2A OS=Homo sapiens OX=9606 GN=SH3PXD2A PE=1 SV=1" "0.030" "False" "1.473" "1" "1" "1" "1" "1133" "125.2" "8.90" "2.47" "1" "other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf07653" "9644" "ENSG00000107957" "SH3PXD2A" "D3DR98; hsa:9644; O43302; Q5TCZ1; Q5TCZ2; Q5TDQ8" "" "CDC42 GTPase cycle; Invadopodia formation" "2" "0" "1.180" "0.983" "0.917" "1.069" "1.070" "0.918" "1.017" "1.223" "1.078" "126.9" "149.8" "124.8" "116.4" "135.7" "135.9" "116.5" "129.1" "155.2" "136.7" "" "" "" "" "" "" "" "" "" "" "126.9" "126.7" "78.9" "84.9" "111.2" "105.5" "89.8" "111.0" "121.2" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "308542735586844623" "False" "Medium" "IsMasterProtein" "Q53FP2" "Novel acetylcholine receptor chaperone OS=Homo sapiens OX=9606 GN=TMEM35A PE=1 SV=2" "0.030" "False" "1.470" "4" "1" "1" "1" "167" "18.4" "10.08" "2.41" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "59353" "ENSG00000126950" "TMEM35A" "hsa:59353; Q53FP2; Q9H7Y3" "" "" "0" "0" "1.146" "1.141" "1.016" "1.196" "0.906" "0.986" "1.047" "0.984" "0.808" "61.6" "70.5" "70.2" "62.5" "73.6" "55.8" "60.7" "64.4" "60.5" "49.7" "" "" "" "" "" "" "" "" "" "" "61.6" "59.7" "44.4" "45.6" "60.3" "43.3" "46.8" "55.4" "47.3" "44.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000438294968273418" "False" "Medium" "IsMasterProtein" "Q9H173" "Nucleotide exchange factor SIL1 OS=Homo sapiens OX=9606 GN=SIL1 PE=1 SV=1" "0.030" "False" "1.467" "2" "1" "1" "1" "461" "52.1" "5.36" "2.22" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "other molecular function" "Pf08609" "64374" "ENSG00000120725" "SIL1" "D3DQC2; hsa:64374; Q8N2L3; Q9H173" "Primary ovarian insufficiency" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-279239733910497261" "False" "Medium" "IsMasterProtein" "Q8NAV1" "Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1" "0.030" "False" "1.466" "4" "1" "2" "1" "312" "37.5" "9.96" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371, Pf12871" "84950" "ENSG00000134748" "PRPF38A" "hsa:84950; Q8NAV1; Q96JW1; Q9BVZ8" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "Medium" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.030" "False" "1.464" "0" "1" "1" "1" "1644" "185.0" "7.97" "2.21" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3752183774953564252" "False" "Medium" "IsMasterProtein" "Q8WY36" "HMG box transcription factor BBX OS=Homo sapiens OX=9606 GN=BBX PE=1 SV=1" "0.030" "False" "1.464" "1" "1" "1" "1" "941" "105.1" "8.79" "2.67" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09667" "56987" "ENSG00000114439" "BBX" "A2RRM7; hsa:56987; Q2TAJ1; Q7L3J8; Q7LBY8; Q8NDB0; Q8WY35; Q8WY36; Q9H0J6" "" "" "0" "0" "0.968" "1.059" "0.944" "1.067" "0.774" "0.962" "1.085" "0.826" "0.816" "51.4" "49.7" "54.4" "48.5" "54.8" "39.7" "49.4" "55.7" "42.4" "41.9" "" "" "" "" "" "" "" "" "" "" "51.4" "42.0" "34.4" "35.4" "44.9" "30.9" "38.1" "47.9" "33.1" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "485577591804044204" "False" "Medium" "IsMasterProtein" "Q96Q45" "Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2" "0.030" "False" "1.463" "2" "1" "1" "1" "408" "45.5" "6.47" "2.30" "1" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf15383" "65062" "ENSG00000155755" "TMEM237" "B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; hsa:65062; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1; Q96Q45" "Joubert syndrome; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7056878073192047652" "False" "Medium" "IsMasterProtein" "Q96JM7" "Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens OX=9606 GN=L3MBTL3 PE=1 SV=2" "0.030" "False" "1.459" "1" "1" "1" "1" "780" "88.3" "6.46" "2.63" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820" "84456" "ENSG00000198945" "L3MBTL3" "hsa:84456; Q4VXE1; Q5VUM9; Q6P9B5; Q96JM7" "" "" "0" "0" "1.147" "1.269" "1.164" "1.536" "0.818" "1.084" "1.326" "1.338" "0.920" "27.7" "31.8" "35.2" "32.3" "42.6" "22.7" "30.1" "36.8" "37.1" "25.5" "" "" "" "" "" "" "" "" "" "" "27.7" "26.9" "22.3" "23.6" "34.9" "17.6" "23.2" "31.6" "29.0" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "Medium" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.030" "False" "1.456" "3" "1" "1" "1" "220" "24.9" "8.60" "0.00" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7985947186271226833" "False" "Medium" "IsMasterProtein" "Q9UPW0" "Forkhead box protein J3 OS=Homo sapiens OX=9606 GN=FOXJ3 PE=1 SV=2" "0.030" "False" "1.453" "1" "1" "1" "1" "622" "68.9" "7.09" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "22887" "ENSG00000198815" "FOXJ3" "A7MBL7; A7MD18; D3DPW2; hsa:22887; Q9NSS7; Q9UPW0" "" "" "0" "0" "0.940" "0.962" "0.991" "0.961" "1.006" "0.966" "0.968" "0.912" "0.914" "253.2" "238.1" "243.6" "251.0" "243.2" "254.6" "244.5" "245.1" "231.0" "231.5" "" "" "" "" "" "" "" "" "" "" "253.2" "201.4" "154.0" "183.0" "199.3" "197.7" "188.5" "210.7" "180.3" "208.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7125243051286610373" "False" "Medium" "IsMasterProtein" "Q96SN8" "CDK5 regulatory subunit-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK5RAP2 PE=1 SV=5" "0.030" "False" "1.445" "0" "1" "1" "1" "1893" "214.9" "5.58" "1.83" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07989" "55755" "ENSG00000136861" "CDK5RAP2" "hsa:55755; Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q96SN8; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "Medium" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.030" "False" "1.444" "2" "1" "1" "1" "726" "80.7" "5.62" "3.09" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "2" "0" "0.984" "1.049" "1.067" "0.934" "0.939" "1.031" "0.984" "1.094" "1.110" "68.0" "66.9" "71.4" "72.6" "63.5" "63.9" "70.2" "66.9" "74.4" "75.5" "" "" "" "" "" "" "" "" "" "" "68.0" "56.6" "45.1" "52.9" "52.0" "49.6" "54.1" "57.5" "58.1" "67.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3724111757375065163" "False" "Medium" "IsMasterProtein" "Q9P0W2" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related OS=Homo sapiens OX=9606 GN=HMG20B PE=1 SV=1" "0.030" "False" "1.444" "3" "1" "1" "1" "317" "35.8" "9.35" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "10362" "ENSG00000064961" "HMG20B" "A6NMS5; D6W616; hsa:10362; Q6IBP8; Q8NBD5; Q9HD21; Q9P0W2; Q9Y491; Q9Y4A2" "" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; HDACs deacetylate histones" "3" "0" "1.118" "0.793" "1.204" "1.175" "1.116" "1.179" "1.250" "1.107" "1.242" "67.7" "75.7" "53.7" "81.6" "79.6" "75.6" "79.9" "84.7" "75.0" "84.2" "" "" "" "" "" "" "" "" "" "" "67.7" "64.1" "34.0" "59.5" "65.2" "58.7" "61.6" "72.8" "58.5" "75.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8320420744586431417" "False" "Medium" "IsMasterProtein" "Q5JV73" "FERM and PDZ domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FRMPD3 PE=1 SV=3" "0.030" "False" "1.441" "1" "1" "2" "1" "1777" "195.5" "8.25" "5.45" "1" "" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373, Pf00595, Pf21477" "" "ENSG00000147234" "FRMPD3" "A0A804HKI5; hsa:84443; Q5JV73; Q96JK8" "" "Neutrophil degranulation" "1" "0" "1.067" "0.886" "1.053" "1.169" "0.995" "1.211" "1.155" "0.824" "0.982" "344.4" "367.4" "305.3" "362.6" "402.5" "342.6" "417.1" "397.6" "283.8" "338.1" "" "" "" "" "" "" "" "" "" "" "344.4" "310.9" "193.0" "264.4" "329.8" "266.0" "321.5" "341.9" "221.5" "303.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4316199333645663287" "False" "Medium" "IsMasterProtein" "Q9NPG3" "Ubinuclein-1 OS=Homo sapiens OX=9606 GN=UBN1 PE=1 SV=2" "0.030" "False" "1.441" "1" "1" "1" "1" "1134" "121.4" "9.33" "2.72" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf08729, Pf14075" "29855" "ENSG00000118900" "UBN1" "B7Z6D3; D3DUE8; hsa:29855; Q13079; Q9NPG3; Q9P1P7" "15q11q13 copy number variation" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "Medium" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.030" "False" "1.439" "5" "1" "1" "1" "141" "15.8" "5.11" "2.60" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2116736278876107348" "False" "Medium" "IsMasterProtein" "Q8IW45" "ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Homo sapiens OX=9606 GN=NAXD PE=1 SV=1" "0.030" "False" "1.438" "2" "1" "1" "1" "347" "36.6" "8.06" "2.33" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01256" "55739" "ENSG00000213995" "NAXD" "B4DXT4; hsa:55739; Q5T9X3; Q8IW45; Q9H7W1; Q9NVF5" "" "Nicotinamide salvaging" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "Medium" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.031" "False" "1.432" "0" "1" "1" "1" "1464" "164.1" "6.32" "2.39" "1" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "" "RND2 GTPase cycle" "1" "0" "0.986" "0.760" "1.052" "1.033" "1.055" "0.888" "1.042" "0.855" "0.958" "82.4" "81.3" "62.7" "86.7" "85.2" "86.9" "73.2" "85.9" "70.4" "78.9" "" "" "" "" "" "" "" "" "" "" "82.4" "68.7" "39.6" "63.2" "69.8" "67.5" "56.4" "73.8" "55.0" "71.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621682819040714037" "False" "Medium" "IsMasterProtein" "Q5T4F7" "Secreted frizzled-related protein 5 OS=Homo sapiens OX=9606 GN=SFRP5 PE=1 SV=3" "0.031" "False" "1.430" "3" "1" "1" "1" "317" "35.5" "8.56" "1.98" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01392, Pf01759" "6425" "ENSG00000120057" "SFRP5" "hsa:6425; O14780; Q5T4F7; Q86TH7" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "" "4" "0" "1.538" "1.621" "1.061" "1.248" "1.037" "1.064" "0.887" "1.274" "1.437" "27.8" "42.8" "45.1" "29.5" "34.7" "28.9" "29.6" "24.7" "35.5" "40.0" "" "" "" "" "" "" "" "" "" "" "27.8" "36.2" "28.5" "21.5" "28.5" "22.4" "22.8" "21.2" "27.7" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7680065627734331684" "False" "Medium" "IsMasterProtein" "Q3KRA6" "UPF0538 protein C2orf76 OS=Homo sapiens OX=9606 GN=C2orf76 PE=1 SV=3" "0.031" "False" "1.428" "6" "1" "1" "1" "126" "14.6" "6.93" "2.33" "1" "" "" "" "Pf10209" "130355" "ENSG00000186132" "C2orf76" "B7ZLS8; hsa:130355; Q3KRA6; Q4VC35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6804468331770006905" "False" "Medium" "IsMasterProtein" "Q96BR6" "Zinc finger protein 669 OS=Homo sapiens OX=9606 GN=ZNF669 PE=1 SV=2" "0.031" "False" "1.422" "2" "1" "1" "1" "464" "52.6" "8.72" "2.09" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13465" "79862" "ENSG00000188295" "ZNF669" "B3KP94; hsa:79862; Q5VT39; Q96BR6; Q9H9Q6" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3081851764267628818" "False" "Medium" "IsMasterProtein" "Q9Y2P8" "RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens OX=9606 GN=RCL1 PE=1 SV=3" "0.032" "False" "1.420" "2" "1" "1" "1" "373" "40.8" "9.26" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01137, Pf05189" "10171" "ENSG00000120158" "RCL1" "D3DRI2; hsa:10171; Q5VYW9; Q5VZU1; Q9H9D0; Q9NY00; Q9P044; Q9Y2P8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.206" "1.925" "0.972" "1.382" "2.143" "1.217" "1.108" "1.873" "1.578" "43.6" "52.6" "83.9" "42.3" "60.2" "93.4" "53.0" "48.3" "81.6" "68.8" "" "" "" "" "" "" "" "" "" "" "43.6" "44.5" "53.0" "30.9" "49.3" "72.5" "40.9" "41.5" "63.7" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5854084735450090801" "False" "Medium" "IsMasterProtein" "Q9UMD9" "Collagen alpha-1(XVII) chain OS=Homo sapiens OX=9606 GN=COL17A1 PE=1 SV=3" "0.032" "False" "1.420" "1" "1" "1" "1" "1497" "150.3" "8.79" "2.34" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01391" "1308" "ENSG00000065618" "COL17A1" "hsa:1308; Q02802; Q5JV36; Q99018; Q9NQK9; Q9UC14; Q9UMD9" "" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; Type I hemidesmosome assembly" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8929546298446422087" "False" "Medium" "IsMasterProtein" "Q8N9Z2" "Coiled-coil domain-containing protein 71L OS=Homo sapiens OX=9606 GN=CCDC71L PE=1 SV=2" "0.032" "False" "1.418" "4" "1" "1" "1" "235" "26.2" "11.71" "0.00" "1" "" "" "" "Pf15374" "168455" "ENSG00000253276" "CCDC71L" "hsa:168455; Q7Z756; Q8N9Z2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "Medium" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.032" "False" "1.411" "3" "1" "1" "1" "283" "31.8" "9.92" "2.50" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Sphingolipid metabolism in senescence" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "3" "0" "0.928" "0.983" "1.031" "1.072" "1.215" "0.907" "1.068" "1.080" "1.002" "143.9" "133.5" "141.5" "148.3" "154.3" "174.8" "130.5" "153.7" "155.4" "144.2" "" "" "" "" "" "" "" "" "" "" "143.9" "113.0" "89.5" "108.1" "126.4" "135.8" "100.6" "132.1" "121.3" "129.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7453155325725910333" "False" "Medium" "IsMasterProtein" "Q9Y2K2" "Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4" "0.032" "False" "1.408" "1" "1" "1" "1" "1321" "144.8" "6.79" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "23387" "ENSG00000160584" "SIK3" "A1A5A8; H0Y494; hsa:23387; J3KPC8; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50; Q9Y2K2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1173585387388503519" "False" "Medium" "IsMasterProtein" "Q9NSC7" "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST6GALNAC1 PE=1 SV=1" "0.032" "False" "1.407" "2" "1" "1" "1" "600" "68.5" "9.92" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00777" "55808" "ENSG00000070526" "ST6GALNAC1" "hsa:55808; Q6UW90; Q9NSC6; Q9NSC7" "Pancreatic cancer subtypes" "Sialic acid metabolism" "2" "0" "1.146" "1.306" "1.310" "1.344" "1.118" "1.335" "1.348" "1.461" "1.269" "60.7" "69.6" "79.3" "79.6" "81.6" "67.9" "81.1" "81.9" "88.7" "77.1" "" "" "" "" "" "" "" "" "" "" "60.7" "58.9" "50.2" "58.0" "66.9" "52.7" "62.5" "70.4" "69.3" "69.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2490175227447477528" "False" "Medium" "IsMasterProtein" "A0A8I5KY20" "Coiled-coil domain-containing 92B OS=Homo sapiens OX=9606 GN=CCDC92B PE=1 SV=1" "0.032" "False" "1.406" "3" "1" "1" "1" "255" "28.6" "9.77" "2.72" "1" "" "" "" "Pf14916" "" "ENSG00000277200" "CCDC92B" "A0A8I5KY20" "" "" "0" "0" "1.077" "1.848" "1.024" "1.090" "2.181" "1.198" "1.010" "1.793" "1.085" "140.8" "151.6" "260.2" "144.1" "153.5" "307.0" "168.7" "142.2" "252.5" "152.8" "" "" "" "" "" "" "" "" "" "" "140.8" "128.3" "164.5" "105.1" "125.7" "238.4" "130.1" "122.2" "197.1" "137.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5766524597252777546" "False" "Medium" "IsMasterProtein" "Q9BX66" "Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SORBS1 PE=1 SV=3" "0.033" "False" "1.402" "1" "1" "1" "1" "1292" "142.4" "6.84" "1.79" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00018, Pf02208, Pf07653, Pf14604" "10580" "ENSG00000095637" "SORBS1" "A0AED4; A6NEK3; A6NID8; A6NJS4; A7MD40; D3DR42; hsa:10580; O43857; Q5T923; Q5T924; Q5T927; Q5T928; Q5T929; Q5T930; Q5T931; Q5T932; Q7LBE5; Q8IVK0; Q8IVQ4; Q96KF3; Q96KF4; Q9BX64; Q9BX65; Q9BX66; Q9P2Q0; Q9UFT2; Q9UHN7; Q9Y338" "Integrin-mediated cell adhesion; PPAR signaling pathway; Insulin signaling" "Smooth Muscle Contraction" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5583372795952313284" "False" "Medium" "IsMasterProtein" "Q12889" "Oviduct-specific glycoprotein OS=Homo sapiens OX=9606 GN=OVGP1 PE=1 SV=1" "0.033" "False" "1.399" "2" "1" "1" "1" "678" "75.4" "8.78" "0.00" "1" "other metabolic processes;other biological processes" "non-structural extracellular;extracellular matrix;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00704" "5016" "ENSG00000085465" "OVGP1" "A0AV19; B9EGE1; Q12889; Q15841" "" "Interaction With Cumulus Cells And The Zona Pellucida" "1" "0" "1.367" "0.752" "1.280" "1.361" "1.357" "1.381" "1.563" "1.140" "1.344" "22.5" "30.7" "16.9" "28.7" "30.6" "30.5" "31.0" "35.1" "25.6" "30.2" "" "" "" "" "" "" "" "" "" "" "22.5" "26.0" "10.7" "21.0" "25.1" "23.7" "23.9" "30.2" "20.0" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8458810131294421202" "False" "Medium" "IsMasterProtein" "Q96IK1" "Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2" "0.033" "False" "1.396" "4" "1" "1" "1" "185" "19.2" "6.33" "2.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05205" "91272" "ENSG00000145919" "BOD1" "B4DXH8; hsa:91272; Q96IK1; Q9BTW1" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "Medium" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.033" "False" "1.395" "0" "1" "1" "1" "34350" "3813.7" "6.35" "2.24" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "Platelet degranulation ; Striated Muscle Contraction" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3392290766648390097" "False" "Medium" "IsMasterProtein" "Q9UPP1" "Histone lysine demethylase PHF8 OS=Homo sapiens OX=9606 GN=PHF8 PE=1 SV=3" "0.033" "False" "1.395" "1" "1" "1" "1" "1060" "117.8" "8.72" "2.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf02373, Pf17811" "23133" "ENSG00000172943" "PHF8" "B3KMV4; B7Z911; hsa:23133; Q5H9U5; Q5JPR9; Q5JPS0; Q5JPS2; Q5JPS3; Q5VUJ4; Q7Z6D4; Q9HAH2; Q9UPP1" "Ectoderm differentiation" "HDMs demethylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6473886272279589766" "False" "Medium" "IsMasterProtein" "Q9Y2X9" "Zinc finger protein 281 OS=Homo sapiens OX=9606 GN=ZNF281 PE=1 SV=1" "0.033" "False" "1.394" "1" "1" "1" "1" "895" "96.9" "8.48" "2.31" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "23528" "ENSG00000162702" "ZNF281" "A6NF48; B3KMX2; hsa:23528; Q5RKW5; Q9NY92; Q9Y2X9" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247298943909741836" "False" "Medium" "IsMasterProtein" "Q5C9Z4" "Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1" "0.033" "False" "1.394" "2" "1" "1" "1" "860" "96.2" "8.10" "0.00" "1" "other biological processes" "nucleus" "" "Pf02847, Pf02854" "64434" "ENSG00000146909" "NOM1" "hsa:64434; Q5C9Z4; Q96I08" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8933587294849828607" "False" "Medium" "IsMasterProtein" "P35247" "Pulmonary surfactant-associated protein D OS=Homo sapiens OX=9606 GN=SFTPD PE=1 SV=3" "0.033" "False" "1.393" "4" "1" "1" "1" "375" "37.7" "6.60" "0.00" "1" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00059, Pf01391, Pf09006" "6441" "ENSG00000133661" "SFTPD" "hsa:6441; P35247; Q5T0M3; Q6FH08; Q86YK9; Q8TCD8; Q9UCJ2; Q9UCJ3" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Toll Like Receptor 4 (TLR4) Cascade; Regulation of TLR by endogenous ligand; Signal regulatory protein family interactions; SARS-CoV-1 activates/modulates innate immune responses; Toll Like Receptor TLR1:TLR2 Cascade; Surfactant metabolism; Defective CSF2RB causes SMDP5; Defective CSF2RA causes SMDP4" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7784023466259841542" "False" "Medium" "IsMasterProtein" "B0I1T2" "Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2" "0.033" "False" "1.392" "1" "1" "1" "1" "1018" "116.4" "8.73" "1.67" "1" "cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "64005" "ENSG00000136286" "MYO1G" "B0I1T2; hsa:64005; Q8TEI9; Q8TES2; Q96BE2; Q96RI5; Q96RI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "Medium" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.033" "False" "1.389" "1" "1" "1" "1" "1630" "174.8" "5.07" "2.13" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "RND2 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; Asymmetric localization of PCP proteins; RHOJ GTPase cycle; RND3 GTPase cycle" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "Medium" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.033" "False" "1.388" "2" "1" "1" "1" "325" "34.3" "8.54" "2.52" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Amino acid metabolism" "Peroxisomal protein import; Synthesis of Ketone Bodies" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7140956900049477078" "False" "Medium" "IsMasterProtein" "Q8IZC7" "Zinc finger protein 101 OS=Homo sapiens OX=9606 GN=ZNF101 PE=1 SV=1" "0.033" "False" "1.388" "2" "1" "1" "1" "436" "50.3" "9.57" "2.66" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "94039" "ENSG00000181896" "ZNF101" "C9JU83; hsa:94039; Q0VDG9; Q8IZC7" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "Medium" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.033" "False" "1.387" "4" "1" "1" "1" "157" "17.2" "8.91" "2.54" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6579369189662832735" "False" "Medium" "IsMasterProtein" "Q8IX04" "Ubiquitin-conjugating enzyme E2 variant 3 OS=Homo sapiens OX=9606 GN=UEVLD PE=1 SV=2" "0.033" "False" "1.386" "2" "1" "1" "1" "471" "52.2" "7.09" "1.84" "1" "protein metabolism;other metabolic processes;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00056, Pf02866, Pf05743" "55293" "ENSG00000151116" "UEVLD" "B2RB69; B4DL43; F5H6L6; H7BYD6; hsa:55293; Q6P2F0; Q8IX04; Q96FF5; Q9NUX7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6055341473087174016" "False" "Medium" "IsMasterProtein" "Q14563" "Semaphorin-3A OS=Homo sapiens OX=9606 GN=SEMA3A PE=1 SV=1" "0.034" "False" "1.383" "1" "1" "1" "1" "771" "88.8" "7.42" "2.35" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding" "Pf01403, Pf18452" "10371" "ENSG00000075213" "SEMA3A" "hsa:10371; Q14563" "Clock-controlled autophagy in bone metabolism" "CRMPs in Sema3A signaling; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3320992659371118958" "False" "Medium" "IsMasterProtein" "Q15392" "Delta(24)-sterol reductase OS=Homo sapiens OX=9606 GN=DHCR24 PE=1 SV=2" "0.034" "False" "1.382" "2" "1" "1" "1" "516" "60.1" "8.16" "2.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01565" "1718" "ENSG00000116133" "DHCR24" "B7Z817; D3DQ51; hsa:1718; Q15392; Q9HBA8" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2567358102546487352" "False" "Medium" "IsMasterProtein" "Q9GZT5" "Protein Wnt-10a OS=Homo sapiens OX=9606 GN=WNT10A PE=1 SV=1" "0.034" "False" "1.380" "2" "1" "1" "1" "417" "46.4" "9.04" "2.34" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf00110" "80326" "ENSG00000135925" "WNT10A" "hsa:80326; Q53S44; Q96TA7; Q9GZT5; Q9H7S8" "Alzheimer's disease and miRNA effects; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "Class B/2 (Secretin family receptors); WNT ligand biogenesis and trafficking" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787871547147205381" "False" "Medium" "IsMasterProtein" "Q86WI3" "Protein NLRC5 OS=Homo sapiens OX=9606 GN=NLRC5 PE=1 SV=3" "0.034" "False" "1.376" "1" "1" "1" "1" "1866" "204.5" "6.44" "2.04" "1" "stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00560, Pf05729, Pf13516, Pf17776, Pf18461" "84166" "ENSG00000140853" "NLRC5" "B5MEF1; C9JMD8; hsa:84166; Q6P4A6; Q86VM7; Q86WI3; Q8NF42; Q8TEE2; Q8TEJ1; Q969L7" "" "Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2959311852295820305" "False" "Medium" "IsMasterProtein" "Q6TFL3" "Coiled-coil domain-containing protein 171 OS=Homo sapiens OX=9606 GN=CCDC171 PE=1 SV=1" "0.034" "False" "1.375" "1" "1" "1" "1" "1326" "152.7" "6.81" "2.70" "1" "" "" "" "" "203238" "ENSG00000164989" "CCDC171" "B7ZM22; Q5SU58; Q6P1W1; Q6TFL3; Q6ZR13; Q8N1Z4; Q8N8L3; Q8TBR2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "Medium" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.034" "False" "1.369" "2" "1" "1" "1" "383" "42.1" "8.73" "1.74" "1" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "Medium" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.035" "False" "1.366" "2" "1" "1" "1" "477" "50.7" "8.16" "2.86" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316251485158664462" "False" "Medium" "IsMasterProtein" "Q8N8A6" "ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3" "0.035" "False" "1.365" "3" "1" "1" "1" "666" "72.4" "8.16" "2.31" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "317781" "ENSG00000185163; ENSG00000288503" "DDX51" "A8MPT9; hsa:317781; Q5CZ71; Q8IXK5; Q8N8A6; Q96ED1" "" "" "0" "0" "1.233" "0.839" "1.291" "0.883" "1.720" "1.476" "1.230" "1.138" "1.553" "14.1" "17.4" "11.8" "18.2" "12.5" "24.3" "20.8" "17.4" "16.1" "21.9" "" "" "" "" "" "" "" "" "" "" "14.1" "14.7" "7.5" "13.3" "10.2" "18.8" "16.1" "14.9" "12.5" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "Medium" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.035" "False" "1.363" "1" "1" "1" "1" "591" "64.0" "9.73" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "RHOG GTPase cycle; RAC2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865861446448502197" "False" "Medium" "IsMasterProtein" "Q9Y2U9" "Kelch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KLHDC2 PE=1 SV=1" "0.035" "False" "1.362" "2" "1" "1" "1" "406" "46.1" "6.61" "1.63" "1" "protein metabolism;other metabolic processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf13418" "23588" "ENSG00000165516" "KLHDC2" "B3KPF9; hsa:23588; Q6IAF0; Q86TY9; Q9Y2U9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4034364937765710536" "False" "Medium" "IsMasterProtein" "Q9UPV0" "Centrosomal protein of 164 kDa OS=Homo sapiens OX=9606 GN=CEP164 PE=1 SV=3" "0.035" "False" "1.361" "1" "1" "1" "1" "1460" "164.2" "5.36" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "" "22897" "ENSG00000110274" "CEP164" "hsa:22897; Q6PKH9; Q7Z2X9; Q9NVS0; Q9UFJ6; Q9UPV0" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4343387826804369897" "False" "Medium" "IsMasterProtein" "Q9BRT8" "Zinc-regulated GTPase metalloprotein activator 1A OS=Homo sapiens OX=9606 GN=ZNG1A PE=1 SV=1" "0.035" "False" "1.354" "2" "1" "1" "1" "395" "44.0" "4.86" "2.52" "1" "developmental processes" "nucleus;other cell component" "other molecular function" "Pf02492, Pf07683" "55871" "ENSG00000172785" "ZNG1A" "A2RU55; A8K3N3; B0AZR4; hsa:55871; Q49AJ1; Q5VVK2; Q6VBU6; Q7Z5Z0; Q7Z652; Q9BRT8; Q9BY38; Q9NYD0" "" "" "0" "0" "1.028" "0.851" "1.084" "0.792" "0.942" "1.010" "0.932" "0.655" "0.943" "83.9" "86.2" "71.4" "90.9" "66.4" "79.0" "84.7" "78.2" "54.9" "79.1" "" "" "" "" "" "" "" "" "" "" "83.9" "73.0" "45.1" "66.3" "54.4" "61.4" "65.3" "67.2" "42.9" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2083271912742150867" "False" "Medium" "IsMasterProtein" "O14948" "Transcription factor EC OS=Homo sapiens OX=9606 GN=TFEC PE=1 SV=1" "0.035" "False" "1.353" "2" "1" "1" "1" "347" "38.8" "5.49" "2.56" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851" "22797" "ENSG00000105967" "TFEC" "B2R8X5; hsa:22797; O14948; Q5H9U8; Q709A4; Q8N6J9" "" "" "0" "0" "1.050" "1.054" "0.948" "1.153" "1.005" "1.343" "1.255" "0.836" "0.996" "63.9" "67.1" "67.3" "60.5" "73.6" "64.2" "85.8" "80.2" "53.4" "63.6" "" "" "" "" "" "" "" "" "" "" "63.9" "56.8" "42.6" "44.1" "60.3" "49.8" "66.1" "68.9" "41.7" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "Medium" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.035" "False" "1.351" "3" "1" "1" "1" "259" "29.8" "7.68" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3431457210334272148" "False" "Medium" "IsMasterProtein" "Q75QN2" "Integrator complex subunit 8 OS=Homo sapiens OX=9606 GN=INTS8 PE=1 SV=1" "0.035" "False" "1.351" "1" "1" "1" "1" "995" "113.0" "7.05" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "" "55656" "ENSG00000164941" "INTS8" "B2RN92; hsa:55656; Q5RKZ3; Q6P1R5; Q75QN2; Q7Z314; Q9NVS6; Q9NWY7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1129741956035432017" "False" "Medium" "IsMasterProtein" "Q9NY74" "Ewing's tumor-associated antigen 1 OS=Homo sapiens OX=9606 GN=ETAA1 PE=1 SV=2" "0.036" "False" "1.348" "2" "1" "1" "1" "926" "103.4" "7.62" "2.18" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity" "Pf15350" "54465" "ENSG00000143971" "ETAA1" "hsa:54465; Q05BT7; Q53SC4; Q9NY74" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6623999782056256246" "False" "Medium" "IsMasterProtein" "O95180" "Voltage-dependent T-type calcium channel subunit alpha-1H OS=Homo sapiens OX=9606 GN=CACNA1H PE=1 SV=4" "0.036" "False" "1.347" "0" "1" "1" "1" "2353" "259.0" "7.37" "0.00" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00520" "8912" "ENSG00000196557" "CACNA1H" "B5ME00; F8WFD1; hsa:8912; O95180; O95802; Q8WWI6; Q96QI6; Q96RZ9; Q9NYY4; Q9NYY5" "Corticotropin-releasing hormone signaling pathway; MAPK signaling pathway; Acetaminophen in analgesia and antipyresis" "NCAM1 interactions; Smooth Muscle Contraction" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703115990630937278" "False" "Medium" "IsMasterProtein" "Q8IYN2" "Transcription elongation factor A protein-like 8 OS=Homo sapiens OX=9606 GN=TCEAL8 PE=1 SV=1" "0.036" "False" "1.344" "6" "1" "1" "1" "117" "13.6" "5.39" "2.33" "1" "" "nucleus" "" "Pf04538" "90843" "ENSG00000180964" "TCEAL8" "hsa:90843; Q8IYN2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4144599890288946510" "False" "Medium" "IsMasterProtein" "O15480" "Melanoma-associated antigen B3 OS=Homo sapiens OX=9606 GN=MAGEB3 PE=1 SV=2" "0.037" "False" "1.343" "4" "1" "1" "1" "346" "39.2" "10.07" "0.00" "1" "other biological processes" "nucleus" "" "Pf01454, Pf12440" "4114" "ENSG00000198798" "MAGEB3" "A0AVE4; B3KQ52; hsa:4114; O15480; O75861" "" "" "0" "0" "1.284" "1.364" "0.968" "1.138" "1.488" "0.963" "1.467" "1.690" "1.212" "24.5" "31.4" "33.4" "23.7" "27.8" "36.4" "23.5" "35.9" "41.3" "29.6" "" "" "" "" "" "" "" "" "" "" "24.5" "26.6" "21.1" "17.3" "22.8" "28.3" "18.2" "30.8" "32.3" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "Medium" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.036" "False" "1.342" "3" "1" "1" "1" "256" "29.5" "7.08" "1.90" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4042052557542696256" "False" "Medium" "IsMasterProtein" "Q8TAP8" "Protein phosphatase 1 regulatory subunit 35 OS=Homo sapiens OX=9606 GN=PPP1R35 PE=1 SV=1" "0.036" "False" "1.342" "3" "1" "1" "1" "253" "27.9" "8.68" "2.74" "1" "developmental processes;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf15503" "221908" "ENSG00000160813" "PPP1R35" "A4D2C5; hsa:221908; Q8TAP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "Medium" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.037" "False" "1.339" "4" "1" "1" "1" "170" "19.5" "5.30" "2.13" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "87908875284979576" "False" "Medium" "IsMasterProtein" "Q9UNA4" "DNA polymerase iota OS=Homo sapiens OX=9606 GN=POLI PE=1 SV=3" "0.037" "False" "1.338" "2" "1" "1" "1" "740" "83.0" "6.07" "1.61" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00817, Pf11799" "11201" "ENSG00000101751" "POLI" "hsa:11201; Q8N590; Q9H0S1; Q9NYH6; Q9UNA4" "DNA repair pathways, full network" "Termination of translesion DNA synthesis; Translesion synthesis by POLI" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4942829277642129799" "False" "Medium" "IsMasterProtein" "Q8WXG9" "Adhesion G-protein coupled receptor V1 OS=Homo sapiens OX=9606 GN=ADGRV1 PE=1 SV=2" "0.037" "False" "1.337" "0" "1" "1" "1" "6306" "692.6" "4.64" "2.18" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00002, Pf03160, Pf03736, Pf13385" "84059" "ENSG00000164199" "ADGRV1" "hsa:84059; O75171; Q8TF58; Q8WXG9; Q9H0X5; Q9UL61" "GPCRs, other" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7425401848780502306" "False" "Medium" "IsMasterProtein" "Q8NDW4" "Zinc finger protein 248 OS=Homo sapiens OX=9606 GN=ZNF248 PE=1 SV=1" "0.037" "False" "1.336" "2" "1" "1" "1" "579" "67.0" "8.25" "3.61" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "57209" "ENSG00000198105" "ZNF248" "hsa:57209; Q8NDV8; Q8NDW4; Q9UMP3" "" "Generic Transcription Pathway" "1" "0" "8.529" "0.816" "4.585" "4.014" "4.927" "2.956" "0.711" "3.685" "2.450" "49.1" "418.7" "40.1" "225.1" "197.0" "241.9" "145.1" "34.9" "180.9" "120.3" "" "" "" "" "" "" "" "" "" "" "49.1" "354.2" "25.3" "164.1" "161.4" "187.8" "111.9" "30.0" "141.2" "108.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5314510564682491561" "False" "Medium" "IsMasterProtein" "Q6ZV29" "Patatin-like phospholipase domain-containing protein 7 OS=Homo sapiens OX=9606 GN=PNPLA7 PE=1 SV=4" "0.037" "False" "1.336" "1" "1" "1" "1" "1317" "145.6" "7.74" "0.00" "1" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00027, Pf01734" "375775" "ENSG00000130653" "PNPLA7" "B5MDD3; hsa:375775; Q5T364; Q658X0; Q658Y3; Q6ZTS1; Q6ZV29; Q86YU8; Q8TAY5; Q96N75; Q9H7N5" "" "Glycerophospholipid catabolism" "1" "0" "0.916" "1.209" "1.057" "1.137" "1.249" "1.159" "1.196" "1.237" "1.311" "35.5" "32.6" "43.0" "37.6" "40.4" "44.4" "41.2" "42.5" "44.0" "46.6" "" "" "" "" "" "" "" "" "" "" "35.5" "27.6" "27.2" "27.4" "33.1" "34.5" "31.7" "36.6" "34.3" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4764537187769056573" "False" "Medium" "IsMasterProtein" "Q96N87" "Inactive sodium-dependent neutral amino acid transporter B(0)AT3 OS=Homo sapiens OX=9606 GN=SLC6A18 PE=2 SV=2" "0.037" "False" "1.333" "2" "1" "1" "1" "628" "70.9" "7.30" "1.89" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00209" "348932" "ENSG00000164363" "SLC6A18" "hsa:348932; Q96N87" "Nuclear receptors meta-pathway; NRF2 pathway; Proximal tubule transport" "Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane; Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria; Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "Medium" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.037" "False" "1.333" "1" "1" "1" "1" "596" "65.4" "6.28" "2.19" "1" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "Nuclear Receptor transcription pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "Medium" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.037" "False" "1.332" "2" "1" "1" "1" "346" "37.2" "6.28" "2.32" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "" "Neutrophil degranulation" "1" "0" "0.982" "0.992" "0.930" "1.055" "1.082" "1.004" "1.136" "0.909" "1.070" "100.7" "98.9" "99.9" "93.7" "106.2" "108.9" "101.1" "114.4" "91.5" "107.8" "" "" "" "" "" "" "" "" "" "" "100.7" "83.6" "63.1" "68.3" "87.0" "84.6" "77.9" "98.4" "71.5" "96.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441989282213060776" "False" "Medium" "IsMasterProtein" "Q16552" "Interleukin-17A OS=Homo sapiens OX=9606 GN=IL17A PE=1 SV=1" "0.037" "False" "1.331" "5" "1" "1" "1" "155" "17.5" "8.50" "2.42" "1" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf06083" "3605" "ENSG00000112115" "IL17A" "hsa:3605; Q16552; Q5T2P0" "IL-17 signaling pathway; Allograft rejection; Development and heterogeneity of the ILC family; Prostaglandin signaling; Overview of proinflammatory and profibrotic mediators; Th17 cell differentiation pathway; Comprehensive IL-17A signaling; COVID-19 and endothelial cell senescence; Neurogenesis regulation in the olfactory epithelium; Immune infiltration in pancreatic cancer; IL-26 signaling pathways; T-cell receptor signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interleukin-4 and Interleukin-13 signaling; Interleukin-17 signaling" "15" "0" "1.050" "0.862" "0.989" "1.102" "0.967" "1.001" "0.917" "1.058" "0.987" "49.4" "51.8" "42.5" "48.8" "54.4" "47.7" "49.4" "45.3" "52.2" "48.7" "" "" "" "" "" "" "" "" "" "" "49.4" "43.8" "26.9" "35.6" "44.6" "37.1" "38.1" "38.9" "40.8" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5758445270937965663" "False" "Medium" "IsMasterProtein" "Q9BXY5" "Calcyphosin-2 OS=Homo sapiens OX=9606 GN=CAPS2 PE=1 SV=3" "0.037" "False" "1.330" "2" "1" "1" "1" "538" "61.7" "8.76" "2.21" "1" "" "" "other molecular function" "Pf13499" "84698" "ENSG00000180881" "CAPS2" "A0A8V8TPT3; hsa:84698; Q6PH84; Q8N242; Q8NAY5; Q9BXY5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "Medium" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.037" "False" "1.330" "5" "1" "1" "1" "182" "20.6" "5.21" "2.70" "1" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "1.135" "1.184" "1.069" "1.083" "1.124" "1.239" "1.112" "1.171" "1.063" "37.7" "42.8" "44.7" "40.3" "40.8" "42.4" "46.7" "41.9" "44.1" "40.1" "" "" "" "" "" "" "" "" "" "" "37.7" "36.2" "28.2" "29.4" "33.5" "32.9" "36.0" "36.0" "34.5" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5989894444069785887" "False" "Medium" "IsMasterProtein" "Q9H9D4" "Zinc finger protein 408 OS=Homo sapiens OX=9606 GN=ZNF408 PE=1 SV=1" "0.037" "False" "1.329" "2" "1" "1" "1" "720" "78.4" "7.24" "2.13" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf21549" "79797" "ENSG00000175213" "ZNF408" "hsa:79797; Q9H9D4" "" "" "0" "0" "1.207" "0.961" "1.289" "1.452" "1.437" "1.511" "1.189" "1.002" "1.137" "26.6" "32.2" "25.6" "34.3" "38.7" "38.3" "40.3" "31.7" "26.7" "30.3" "" "" "" "" "" "" "" "" "" "" "26.6" "27.2" "16.2" "25.0" "31.7" "29.7" "31.0" "27.2" "20.8" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097674846330682720" "False" "Medium" "IsMasterProtein" "O15037" "Protein KHNYN OS=Homo sapiens OX=9606 GN=KHNYN PE=1 SV=3" "0.037" "False" "1.328" "1" "1" "1" "1" "678" "74.5" "7.02" "0.00" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977" "23351" "ENSG00000100441" "KHNYN" "hsa:23351; O15037; Q86TZ6; Q8IUQ2; Q96BA9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501426655381340633" "False" "Medium" "IsMasterProtein" "Q9P1Z0" "Zinc finger and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZBTB4 PE=1 SV=3" "0.037" "False" "1.328" "2" "1" "1" "1" "1013" "105.0" "8.37" "0.00" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "57659" "ENSG00000174282; ENSG00000283868" "ZBTB4" "B3KVL6; hsa:57659; Q7Z697; Q86XJ4; Q8N4V8; Q9P1Z0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2896751395551910999" "False" "Medium" "IsMasterProtein" "O95236" "Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3" "0.037" "False" "1.328" "2" "1" "1" "1" "402" "44.3" "8.16" "2.46" "1" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other cell component" "transporter activity;other molecular function" "Pf05461" "80833" "ENSG00000128284" "APOL3" "B1AHI4; B1AHI5; hsa:80833; O95236; Q5U5N4; Q9BQ82; Q9BQA3" "" "" "0" "0" "1.036" "1.010" "1.157" "1.188" "1.059" "1.249" "1.134" "0.955" "0.932" "82.8" "85.8" "83.6" "95.8" "98.3" "87.6" "103.4" "93.9" "79.0" "77.2" "" "" "" "" "" "" "" "" "" "" "82.8" "72.6" "52.9" "69.9" "80.6" "68.1" "79.7" "80.7" "61.7" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Medium" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.037" "False" "1.327" "1" "1" "2" "1" "904" "102.1" "7.77" "5.62" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "1.037" "0.909" "0.977" "0.929" "0.986" "0.901" "0.974" "0.982" "0.983" "202.8" "210.2" "184.4" "198.1" "188.4" "199.9" "182.7" "197.5" "199.2" "199.4" "" "" "" "" "" "" "" "" "" "" "202.8" "177.9" "116.6" "144.5" "154.4" "155.3" "140.9" "169.8" "155.5" "179.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "138932936592921501" "False" "Medium" "IsMasterProtein" "Q9ULJ3" "Zinc finger and BTB domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZBTB21 PE=1 SV=2" "0.037" "False" "1.325" "1" "1" "1" "1" "1066" "118.8" "8.29" "2.96" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf18450" "49854" "ENSG00000173276" "ZBTB21" "hsa:49854; Q5R2W1; Q5R2W2; Q6P4R0; Q9ULJ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6481772682994678680" "False" "Medium" "IsMasterProtein" "Q5VYJ5" "MAM and LDL-receptor class A domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MALRD1 PE=1 SV=4" "0.037" "False" "1.324" "1" "1" "1" "1" "2156" "240.9" "5.22" "0.00" "1" "other biological processes" "other membranes;ER/Golgi" "" "Pf00008, Pf00057, Pf00629" "340895" "ENSG00000204740" "MALRD1" "B7ZBP2; hsa:340895; Q5VYJ5; R9WAE9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6651828163835198711" "False" "Medium" "IsMasterProtein" "O95997" "Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1" "0.037" "False" "1.324" "3" "1" "1" "1" "202" "22.0" "6.60" "2.67" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04856" "9232" "ENSG00000164611" "PTTG1" "hsa:9232; O95997" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8825052418605142423" "False" "Medium" "IsMasterProtein" "Q8TF30" "WASP homolog-associated protein with actin, membranes and microtubules OS=Homo sapiens OX=9606 GN=WHAMM PE=1 SV=2" "0.037" "False" "1.323" "1" "1" "1" "1" "809" "90.9" "7.08" "2.34" "1" "cell adhesion;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf15871, Pf15920" "123720" "ENSG00000156232" "WHAMM" "hsa:123720; Q8N1J9; Q8TF30" "15q25 copy number variation" "RHOD GTPase cycle" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1659957143710920919" "False" "Medium" "IsMasterProtein" "Q8TF46" "DIS3-like exonuclease 1 OS=Homo sapiens OX=9606 GN=DIS3L PE=1 SV=2" "0.037" "False" "1.322" "1" "1" "1" "1" "1054" "120.7" "6.54" "1.98" "1" "RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17215, Pf17216, Pf17849" "115752" "ENSG00000166938" "DIS3L" "hsa:115752; Q8N1N8; Q8TF46; Q8WTU9; Q96CM7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "Medium" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.037" "False" "1.321" "10" "1" "1" "1" "111" "13.5" "8.78" "0.00" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.846" "0.418" "0.782" "1.104" "0.956" "0.651" "1.115" "0.903" "0.856" "18.0" "15.2" "7.5" "14.1" "19.9" "17.2" "11.7" "20.1" "16.2" "15.4" "" "" "" "" "" "" "" "" "" "" "18.0" "12.9" "4.8" "10.3" "16.3" "13.4" "9.0" "17.2" "12.7" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "Medium" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.037" "False" "1.321" "1" "1" "1" "1" "559" "61.6" "6.46" "2.42" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; RAC1 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945002004547854697" "False" "Medium" "IsMasterProtein" "Q8N7B6" "PACRG-like protein OS=Homo sapiens OX=9606 GN=PACRGL PE=1 SV=2" "0.038" "False" "1.316" "5" "1" "1" "1" "248" "27.1" "9.67" "2.25" "1" "" "" "" "Pf10274" "133015" "ENSG00000163138" "PACRGL" "B2RDB9; B4DFF8; B4DMN7; hsa:133015; Q8N7B6; Q8TBA8" "" "" "0" "0" "1.110" "0.701" "1.222" "0.954" "0.994" "0.984" "0.932" "0.918" "0.763" "21.3" "23.6" "14.9" "26.0" "20.3" "21.1" "20.9" "19.8" "19.5" "16.2" "" "" "" "" "" "" "" "" "" "" "21.3" "20.0" "9.4" "19.0" "16.6" "16.4" "16.1" "17.1" "15.2" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194224885782159223" "False" "Medium" "IsMasterProtein" "Q92611" "ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Homo sapiens OX=9606 GN=EDEM1 PE=1 SV=1" "0.038" "False" "1.315" "2" "1" "1" "1" "657" "73.7" "6.92" "2.08" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01532" "9695" "ENSG00000134109" "EDEM1" "A8K9C8; B4DXP3; hsa:9695; Q92611" "Photodynamic therapy-induced unfolded protein response" "ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes" "3" "0" "1.258" "0.992" "1.287" "1.119" "1.211" "0.899" "1.321" "0.871" "0.848" "24.4" "30.7" "24.2" "31.4" "27.3" "29.5" "21.9" "32.2" "21.2" "20.7" "" "" "" "" "" "" "" "" "" "" "24.4" "25.9" "15.3" "22.9" "22.3" "22.9" "16.9" "27.7" "16.6" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "Medium" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.038" "False" "1.313" "4" "1" "1" "1" "228" "24.8" "9.63" "3.49" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "0.923" "1.077" "0.916" "0.877" "0.963" "0.997" "1.053" "1.071" "1.065" "239.5" "221.1" "257.9" "219.4" "210.0" "230.7" "238.9" "252.3" "256.6" "255.2" "" "" "" "" "" "" "" "" "" "" "239.5" "187.0" "163.1" "160.0" "172.1" "179.2" "184.2" "216.9" "200.3" "229.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6381027269296732412" "False" "Medium" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "0.038" "False" "1.310" "1" "1" "1" "1" "1133" "128.8" "7.14" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "Genes related to primary cilium development (based on CRISPR)" "RAB GEFs exchange GTP for GDP on RABs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8634807858830786890" "False" "Medium" "IsMasterProtein" "Q9BYW1" "Solute carrier family 2, facilitated glucose transporter member 11 OS=Homo sapiens OX=9606 GN=SLC2A11 PE=1 SV=1" "0.038" "False" "1.309" "2" "1" "1" "1" "496" "53.7" "8.18" "0.00" "1" "transport" "plasma membrane;other membranes;nucleus;other cell component" "transporter activity" "Pf00083" "66035" "ENSG00000133460; ENSG00000275744" "SLC2A11" "E9PH55; hsa:66035; Q542Y4; Q6ICJ5; Q8WXF9; Q8WYM4; Q9BYW1" "Nuclear receptors meta-pathway; NRF2 pathway" "Cellular hexose transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7567103960318727217" "False" "Medium" "IsMasterProtein" "Q08999" "Retinoblastoma-like protein 2 OS=Homo sapiens OX=9606 GN=RBL2 PE=1 SV=3" "0.039" "False" "1.308" "1" "1" "1" "1" "1139" "128.3" "7.44" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf11934" "5934" "ENSG00000103479" "RBL2" "B7Z913; hsa:5934; Q08999; Q15073; Q16084; Q8NE70; Q92812" "Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Adipogenesis; TGF-beta signaling pathway; PI3K-Akt signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway; DNA damage response (only ATM dependent); Monoamine transport" "Cyclin D associated events in G1; FOXO-mediated transcription of cell cycle genes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "18" "0" "1.100" "1.095" "1.111" "1.097" "1.255" "1.148" "1.120" "1.071" "1.045" "119.9" "131.8" "131.2" "133.2" "131.5" "150.4" "137.6" "134.2" "128.4" "125.2" "" "" "" "" "" "" "" "" "" "" "119.9" "111.5" "83.0" "97.1" "107.7" "116.8" "106.1" "115.4" "100.2" "112.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2490705323878985968" "False" "Medium" "IsMasterProtein" "Q96M29" "Tektin-5 OS=Homo sapiens OX=9606 GN=TEKT5 PE=1 SV=1" "0.040" "False" "1.307" "2" "1" "1" "1" "485" "56.3" "7.14" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton" "" "Pf03148" "146279" "ENSG00000153060" "TEKT5" "A1L3Z3; hsa:146279; Q96M29" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "Medium" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.040" "False" "1.305" "0" "1" "1" "1" "3969" "431.5" "9.09" "2.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "Histone modifications" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "6" "0" "0.985" "1.369" "1.018" "1.035" "1.710" "1.197" "1.075" "1.366" "1.335" "33.9" "33.3" "46.3" "34.5" "35.1" "57.9" "40.5" "36.4" "46.2" "45.2" "" "" "" "" "" "" "" "" "" "" "33.9" "28.2" "29.3" "25.1" "28.7" "45.0" "31.2" "31.3" "36.1" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547605808650954540" "False" "Medium" "IsMasterProtein" "Q01955" "Collagen alpha-3(IV) chain OS=Homo sapiens OX=9606 GN=COL4A3 PE=1 SV=3" "0.040" "False" "1.305" "1" "1" "1" "1" "1670" "161.7" "9.16" "2.53" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf01391, Pf01413" "1285" "ENSG00000169031" "COL4A3" "hsa:1285; Q01955; Q53QQ1; Q53R14; Q53RW8; Q9BQT2; Q9NYC4; Q9UDJ9; Q9UDK9; Q9UDL0; Q9UDL1" "Primary focal segmental glomerulosclerosis (FSGS); PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Small cell lung cancer; Nephrotic syndrome; Pleural mesothelioma" "Collagen degradation; Signaling by PDGF; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; Laminin interactions; Anchoring fibril formation; Crosslinking of collagen fibrils" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1082810895474363705" "False" "Medium" "IsMasterProtein" "P06746" "DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3" "0.040" "False" "1.304" "2" "1" "1" "1" "335" "38.2" "8.95" "2.23" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "5423" "ENSG00000070501" "POLB" "B2RC78; hsa:5423; P06746; Q3KP48; Q6FI34" "Male infertility; Base excision repair; DNA repair pathways, full network" "Ub-specific processing proteases; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5113146668834443448" "False" "Medium" "IsMasterProtein" "Q9NRG4" "N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2" "0.040" "False" "1.303" "2" "1" "1" "1" "433" "49.7" "6.71" "2.40" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "56950" "ENSG00000143499" "SMYD2" "B2R9P9; hsa:56950; I6L9H7; Q4V765; Q5VSH9; Q96AI4; Q9NRG4" "Histone modifications" "PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4499853183750270737" "False" "Medium" "IsMasterProtein" "O60284" "Suppression of tumorigenicity 18 protein OS=Homo sapiens OX=9606 GN=ST18 PE=1 SV=1" "0.040" "False" "1.301" "1" "1" "1" "1" "1047" "115.1" "6.06" "2.19" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01530, Pf08474" "9705" "ENSG00000147488" "ST18" "hsa:9705; O60284; Q17RY1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5936229442522610236" "False" "Medium" "IsMasterProtein" "Q9H204" "Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1" "0.040" "False" "1.297" "4" "1" "1" "1" "178" "19.5" "5.58" "3.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity" "Pf11594" "80306" "ENSG00000118579" "MED28" "hsa:80306; Q9BZJ5; Q9H204" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.988" "0.888" "0.985" "0.997" "0.835" "1.072" "0.995" "0.825" "0.989" "85.6" "84.6" "76.1" "84.4" "85.4" "71.5" "91.8" "85.2" "70.7" "84.7" "" "" "" "" "" "" "" "" "" "" "85.6" "71.6" "48.1" "61.5" "70.0" "55.6" "70.8" "73.3" "55.2" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5837225809424381126" "False" "Medium" "IsMasterProtein" "P51826" "AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3" "0.040" "False" "1.296" "1" "1" "1" "1" "1226" "133.4" "8.10" "2.85" "1" "developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05110, Pf18875, Pf18876" "3899" "ENSG00000144218" "AFF3" "B7ZM46; B9EGL9; D3DVI6; P51826; Q53RD6; Q53S47; Q53SI6; Q53TB9; Q59F27; Q8IWJ5" "" "" "0" "0" "1.015" "0.750" "0.948" "0.801" "0.740" "0.995" "0.822" "1.047" "0.835" "91.6" "93.0" "68.7" "86.8" "73.4" "67.8" "91.2" "75.3" "95.9" "76.5" "" "" "" "" "" "" "" "" "" "" "91.6" "78.7" "43.4" "63.3" "60.1" "52.7" "70.3" "64.7" "74.9" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-813312959545056598" "False" "Medium" "IsMasterProtein" "Q96DT7" "Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2" "0.040" "False" "1.296" "2" "1" "1" "1" "871" "94.8" "5.16" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "65986" "ENSG00000205189" "ZBTB10" "A4FVD0; hsa:65986; Q86W96; Q8IXI9; Q96DT7; Q96MH9" "" "" "0" "0" "0.385" "0.185" "0.286" "0.429" "0.247" "0.305" "0.281" "1.206" "0.130" "229.2" "88.3" "42.5" "65.5" "98.5" "56.7" "69.9" "64.4" "276.4" "29.8" "" "" "" "" "" "" "" "" "" "" "229.2" "74.7" "26.9" "47.8" "80.7" "44.1" "53.9" "55.3" "215.7" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "244400377751924858" "False" "Medium" "IsMasterProtein" "Q9HCE0" "Ectopic P granules protein 5 homolog OS=Homo sapiens OX=9606 GN=EPG5 PE=1 SV=2" "0.040" "False" "1.296" "0" "1" "1" "1" "2579" "292.3" "6.43" "2.20" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other cytoplasmic organelle;other cell component" "" "" "57724" "ENSG00000152223" "EPG5" "A2BDF3; hsa:57724; Q9H8C8; Q9HCE0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627729805625974118" "False" "Medium" "IsMasterProtein" "Q96M34" "Testis-specific expressed protein 55 OS=Homo sapiens OX=9606 GN=TEX55 PE=1 SV=2" "0.040" "False" "1.296" "3" "1" "1" "1" "536" "60.1" "5.80" "2.41" "1" "" "nucleus" "" "Pf17819" "152405" "ENSG00000163424" "TEX55" "A1L4B7; hsa:152405; Q96M34" "" "" "0" "0" "1.986" "1.016" "1.385" "1.541" "1.593" "1.124" "0.993" "1.672" "1.278" "27.9" "55.3" "28.3" "38.6" "42.9" "44.4" "31.3" "27.7" "46.6" "35.6" "" "" "" "" "" "" "" "" "" "" "27.9" "46.8" "17.9" "28.1" "35.2" "34.5" "24.1" "23.8" "36.4" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756006190892429286" "False" "Medium" "IsMasterProtein" "P33260" "Cytochrome P450 2C18 OS=Homo sapiens OX=9606 GN=CYP2C18 PE=1 SV=3" "0.040" "False" "1.295" "2" "1" "1" "1" "490" "55.7" "7.20" "2.86" "1" "other metabolic processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00067" "1562" "ENSG00000108242" "CYP2C18" "B2R8K2; hsa:1562; P33260; Q16703; Q16751; Q4VAT5; Q6GRG1" "Oxidation by cytochrome P450; Eicosanoid metabolism via cytochrome P450 monooxygenases pathway; Metapathway biotransformation Phase I and II" "Xenobiotics" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5366408655713326940" "False" "Medium" "IsMasterProtein" "Q07817" "Bcl-2-like protein 1 OS=Homo sapiens OX=9606 GN=BCL2L1 PE=1 SV=1" "0.040" "False" "1.288" "4" "1" "1" "1" "233" "26.0" "4.93" "2.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00452, Pf02180" "598" "ENSG00000171552" "BCL2L1" "E1P5L6; hsa:598; Q07817; Q5CZ89; Q5TE65; Q92976" "Leptin signaling pathway; IL-7 signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); IL-3 signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; lncRNA-mediated mechanisms of therapeutic resistance; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis" "Interleukin-4 and Interleukin-13 signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; RAS processing; NFE2L2 regulating tumorigenic genes; The NLRP1 inflammasome; STAT5 activation downstream of FLT3 ITD mutants; SARS-CoV-1-mediated effects on programmed cell death" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1933221655195887303" "False" "Medium" "IsMasterProtein" "Q9ULX9" "Transcription factor MafF OS=Homo sapiens OX=9606 GN=MAFF PE=1 SV=2" "0.040" "False" "1.280" "4" "1" "1" "1" "164" "17.7" "9.80" "2.33" "1" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "23764" "ENSG00000185022" "MAFF" "B4DV49; hsa:23764; Q9ULX9; Q9Y525" "Nuclear receptors meta-pathway; NRF2 pathway; Myometrial relaxation and contraction pathways; Ethanol metabolism production of ROS by CYP2E1; Orexin receptor pathway" "Factors involved in megakaryocyte development and platelet production" "6" "0" "1.237" "0.848" "1.271" "1.104" "1.034" "1.084" "0.965" "0.956" "1.110" "42.4" "52.4" "35.9" "53.9" "46.8" "43.8" "45.9" "40.9" "40.5" "47.0" "" "" "" "" "" "" "" "" "" "" "42.4" "44.4" "22.7" "39.3" "38.3" "34.0" "35.4" "35.2" "31.6" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417113921000243817" "False" "Medium" "IsMasterProtein" "Q5JPI3" "Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1" "0.040" "False" "1.278" "3" "1" "1" "1" "329" "37.5" "6.47" "1.98" "1" "other biological processes" "nucleus" "" "Pf15008" "285237" "ENSG00000179021" "C3orf38" "B2R8X6; hsa:285237; Q5JPI3; Q8TC85" "" "" "0" "0" "1.247" "1.344" "1.342" "1.369" "1.228" "1.095" "1.205" "1.354" "1.281" "50.5" "62.9" "67.8" "67.7" "69.1" "62.0" "55.2" "60.8" "68.3" "64.7" "" "" "" "" "" "" "" "" "" "" "50.5" "53.2" "42.9" "49.4" "56.6" "48.1" "42.6" "52.3" "53.3" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1043933861816378704" "False" "Medium" "IsMasterProtein" "O60303" "Katanin-interacting protein OS=Homo sapiens OX=9606 GN=KATNIP PE=1 SV=4" "0.041" "False" "1.278" "1" "1" "1" "1" "1618" "180.8" "5.87" "0.00" "1" "transport" "cytoskeleton;other cell component" "" "Pf14652" "23247" "ENSG00000047578" "KATNIP" "A7E2C2; hsa:23247; O60303" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5788706850486751146" "False" "Medium" "IsMasterProtein" "O95672" "Endothelin-converting enzyme-like 1 OS=Homo sapiens OX=9606 GN=ECEL1 PE=1 SV=3" "0.041" "False" "1.278" "1" "1" "1" "1" "775" "87.7" "7.03" "1.88" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf01431, Pf05649" "9427" "ENSG00000171551" "ECEL1" "hsa:9427; O95672; Q45UD9; Q53RF9; Q6UW86; Q86TH4; Q9NY95" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "Medium" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.041" "False" "1.276" "1" "1" "1" "1" "1214" "136.0" "6.71" "1.89" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "IL-18 signaling pathway" "RHOQ GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "Medium" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.041" "False" "1.275" "1" "1" "1" "1" "718" "78.9" "8.27" "3.33" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "3" "0" "1.036" "1.105" "0.809" "0.779" "1.065" "0.867" "0.780" "1.077" "0.973" "76.2" "79.0" "84.2" "61.7" "59.4" "81.2" "66.1" "59.4" "82.1" "74.1" "" "" "" "" "" "" "" "" "" "" "76.2" "66.8" "53.2" "45.0" "48.6" "63.1" "50.9" "51.1" "64.1" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6995869173039839710" "False" "Medium" "IsMasterProtein" "P19099" "Cytochrome P450 11B2, mitochondrial OS=Homo sapiens OX=9606 GN=CYP11B2 PE=1 SV=3" "0.041" "False" "1.274" "2" "1" "2" "1" "503" "57.5" "9.39" "2.04" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00067" "1585" "ENSG00000179142" "CYP11B2" "B0ZBE4; hsa:1585; P19099; Q16726" "Oxidation by cytochrome P450; Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism; Nephrotic syndrome; FGF23 signaling in hypophosphatemic rickets and related disorders; Orexin receptor pathway; ACE inhibitor pathway; Metapathway biotransformation Phase I and II" "Endogenous sterols; Glucocorticoid biosynthesis; Mineralocorticoid biosynthesis; Defective CYP11B2 causes CMO-1 deficiency" "11" "0" "0.962" "1.003" "1.011" "1.157" "1.019" "1.138" "1.141" "1.024" "0.907" "208.1" "200.3" "208.7" "210.5" "240.9" "212.2" "236.8" "237.5" "213.2" "188.9" "" "" "" "" "" "" "" "" "" "" "208.1" "169.5" "131.9" "153.5" "197.4" "164.8" "182.6" "204.2" "166.4" "169.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "Medium" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.041" "False" "1.273" "2" "1" "1" "1" "390" "44.3" "8.53" "2.41" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Cell surface interactions at the vascular wall; Transcriptional regulation of white adipocyte differentiation; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "95" "0" "1.210" "0.885" "0.985" "0.983" "0.944" "1.148" "1.177" "0.893" "0.984" "52.4" "63.4" "46.4" "51.6" "51.5" "49.5" "60.2" "61.7" "46.8" "51.6" "" "" "" "" "" "" "" "" "" "" "52.4" "53.6" "29.3" "37.6" "42.2" "38.4" "46.4" "53.0" "36.5" "46.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8548442612232049091" "False" "Medium" "IsMasterProtein" "Q9NY46" "Sodium channel protein type 3 subunit alpha OS=Homo sapiens OX=9606 GN=SCN3A PE=1 SV=2" "0.041" "False" "1.273" "1" "1" "1" "1" "2000" "226.1" "5.80" "2.28" "1" "stress response;transport" "plasma membrane;other membranes;cytosol" "transporter activity" "Pf00520, Pf06512, Pf11933" "6328" "ENSG00000153253" "SCN3A" "hsa:6328; Q16142; Q53SX0; Q9BZB3; Q9C006; Q9NY46; Q9NYK2; Q9P2J1; Q9UPD1; Q9Y6P4" "" "Sensory perception of sweet, bitter, and umami (glutamate) taste; Interaction between L1 and Ankyrins; Phase 0 - rapid depolarisation" "3" "0" "1.246" "1.344" "1.064" "1.319" "1.502" "1.238" "1.140" "1.198" "1.438" "38.5" "47.9" "51.7" "40.9" "50.8" "57.8" "47.6" "43.9" "46.1" "55.3" "" "" "" "" "" "" "" "" "" "" "38.5" "40.6" "32.7" "29.9" "41.6" "44.9" "36.7" "37.7" "36.0" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705031560039491715" "False" "Medium" "IsMasterProtein" "Q8IUQ4" "E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens OX=9606 GN=SIAH1 PE=1 SV=2" "0.041" "False" "1.271" "3" "1" "1" "1" "282" "31.1" "6.80" "2.70" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03145, Pf21361, Pf21362" "6477" "ENSG00000196470" "SIAH1" "A0FKF3; hsa:6477; O43269; Q49A58; Q8IUQ4; Q92880" "Parkin-ubiquitin proteasomal system pathway; miRNA regulation of p53 pathway in prostate cancer; HIPK2 in kidney fibrosis; 16p11.2 proximal deletion syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; Netrin-1 signaling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1218234531041792336" "False" "Medium" "IsMasterProtein" "Q8NHY6" "Zinc finger protein 28 homolog OS=Homo sapiens OX=9606 GN=ZFP28 PE=1 SV=1" "0.041" "False" "1.265" "1" "1" "1" "1" "868" "98.6" "9.32" "2.32" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "140612" "ENSG00000196867" "ZFP28" "A0JNV6; hsa:140612; K7ES88; Q8NHU8; Q8NHY6; Q9BY30; Q9P2B6" "Orexin receptor pathway" "Generic Transcription Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "Medium" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.042" "False" "1.264" "2" "1" "1" "1" "403" "43.5" "8.53" "2.47" "1" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "0.963" "1.080" "1.096" "1.053" "1.019" "1.059" "1.184" "0.884" "1.082" "51.8" "49.9" "55.9" "56.8" "54.5" "52.8" "54.9" "61.3" "45.8" "56.0" "" "" "" "" "" "" "" "" "" "" "51.8" "42.2" "35.4" "41.4" "44.7" "41.0" "42.3" "52.7" "35.7" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "Medium" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.042" "False" "1.261" "1" "1" "1" "1" "1353" "150.4" "7.71" "0.00" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6357047433893441772" "False" "Medium" "IsMasterProtein" "P36222" "Chitinase-3-like protein 1 OS=Homo sapiens OX=9606 GN=CHI3L1 PE=1 SV=2" "0.042" "False" "1.260" "2" "1" "1" "1" "383" "42.6" "8.46" "0.00" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf00704" "1116" "ENSG00000133048" "CHI3L1" "B2R7B0; hsa:1116; P30923; P36222; Q8IVA4; Q96HI7" "Mammary gland development pathway - Involution (Stage 4 of 4)" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "Medium" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.042" "False" "1.257" "3" "1" "1" "1" "316" "35.7" "6.11" "1.79" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765317392758550042" "False" "Medium" "IsMasterProtein" "Q3T8J9" "GON-4-like protein OS=Homo sapiens OX=9606 GN=GON4L PE=1 SV=1" "0.042" "False" "1.257" "0" "1" "1" "1" "2241" "248.5" "5.01" "0.00" "1" "other biological processes" "nucleus" "other molecular function" "Pf02671, Pf21227" "54856" "ENSG00000116580" "GON4L" "B7ZBL4; hsa:54856; Q14C93; Q3T8J8; Q3T8J9; Q5VYZ5; Q5W0D5; Q6AWA6; Q6P1Q6; Q7Z3L3; Q8IY79; Q9BQI1; Q9HCG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8564696200648567911" "False" "Medium" "IsMasterProtein" "O60930" "Ribonuclease H1 OS=Homo sapiens OX=9606 GN=RNASEH1 PE=1 SV=2" "0.043" "False" "1.252" "3" "1" "1" "1" "286" "32.0" "9.16" "2.27" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00075, Pf01693" "246243" "ENSG00000171865" "RNASEH1" "B3KQU4; hsa:246243; O60523; O60857; O60930; Q57Z93; Q5U0C1; Q6FHD4" "" "" "0" "0" "0.877" "1.119" "1.126" "0.929" "0.992" "1.176" "1.179" "1.211" "1.182" "38.3" "33.6" "42.8" "43.1" "35.6" "38.0" "45.0" "45.1" "46.4" "45.3" "" "" "" "" "" "" "" "" "" "" "38.3" "28.4" "27.1" "31.4" "29.1" "29.5" "34.7" "38.8" "36.2" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277143730567108241" "False" "Medium" "IsMasterProtein" "Q7Z6L1" "Tectonin beta-propeller repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TECPR1 PE=1 SV=1" "0.043" "False" "1.249" "1" "1" "1" "1" "1165" "129.6" "6.24" "2.01" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf06398, Pf06462, Pf19193" "25851" "ENSG00000205356" "TECPR1" "A8KAD1; B3KPZ1; C9J024; F5GX57; hsa:25851; Q7Z6L1; Q96EB0; Q9P2I9; Q9UFR6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "Medium" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.043" "False" "1.247" "1" "1" "1" "1" "660" "74.4" "8.16" "2.40" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "TYSND1 cleaves peroxisomal proteins" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805151388024258847" "False" "Medium" "IsMasterProtein" "Cont_Q28107" "Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=1 SV=1" "0.043" "True" "1.245" "0" "1" "1" "1" "2211" "248.8" "5.83" "2.67" "1" "stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00754, Pf06049, Pf07732" "280687" "" "F5" "bta:280687; Q28107; Q28108" "" "" "0" "0" "0.968" "1.269" "1.537" "1.254" "1.709" "1.198" "1.172" "1.554" "1.291" "19.2" "18.6" "24.4" "29.5" "24.1" "32.8" "23.0" "22.5" "29.9" "24.8" "" "" "" "" "" "" "" "" "" "" "19.2" "15.7" "15.4" "21.5" "19.7" "25.5" "17.8" "19.4" "23.3" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "Medium" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.043" "False" "1.243" "4" "1" "1" "1" "227" "24.4" "6.89" "2.80" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357573527050383496" "False" "Medium" "IsMasterProtein" "Q9BYX4" "Interferon-induced helicase C domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IFIH1 PE=1 SV=3" "0.043" "False" "1.241" "1" "1" "1" "1" "1025" "116.6" "5.52" "2.25" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00271, Pf00619, Pf04851, Pf11648, Pf16739, Pf18119" "64135" "ENSG00000115267" "IFIH1" "hsa:64135; Q2NKL6; Q6DC96; Q86X56; Q96MX8; Q9BYX4; Q9H3G6" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Lung pathology of COVID-19; 1p36 copy number variation syndrome" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; Ub-specific processing proteases; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; Evasion by RSV of host interferon responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2838998273344652041" "False" "Medium" "IsMasterProtein" "Q14999" "Cullin-7 OS=Homo sapiens OX=9606 GN=CUL7 PE=1 SV=2" "0.044" "False" "1.239" "1" "1" "1" "1" "1698" "191.0" "5.87" "3.33" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00888, Pf03256, Pf11515" "9820" "ENSG00000044090" "CUL7" "B4DYZ0; F5H0L1; hsa:9820; Q14999; Q5T654" "" "XBP1(S) activates chaperone genes; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "1.029" "1.064" "0.840" "0.784" "0.898" "0.785" "0.742" "1.050" "0.705" "90.3" "92.9" "96.1" "75.9" "70.8" "81.1" "70.9" "67.0" "94.7" "63.7" "" "" "" "" "" "" "" "" "" "" "90.3" "78.6" "60.7" "55.3" "58.0" "63.0" "54.6" "57.6" "73.9" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4395241715335713801" "False" "Medium" "IsMasterProtein" "Q13595" "Transformer-2 protein homolog alpha OS=Homo sapiens OX=9606 GN=TRA2A PE=1 SV=1" "0.044" "False" "1.238" "2" "1" "1" "1" "282" "32.7" "11.27" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "29896" "ENSG00000164548" "TRA2A" "B4DQI6; B4DUA9; E9PD75; hsa:29896; Q13595" "Orexin receptor pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6666677363642983444" "False" "Medium" "IsMasterProtein" "O75182" "Paired amphipathic helix protein Sin3b OS=Homo sapiens OX=9606 GN=SIN3B PE=1 SV=2" "0.044" "False" "1.235" "1" "1" "1" "1" "1162" "133.0" "6.93" "0.00" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf02671, Pf08295, Pf16879" "23309" "ENSG00000127511" "SIN3B" "hsa:23309; O75182; Q2NL91; Q68GC2; Q6P4B8; Q8TB34; Q9BSC8" "" "NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "-9177042423302536619" "False" "Medium" "IsMasterProtein" "Q5FWF6" "Zinc finger protein 789 OS=Homo sapiens OX=9606 GN=ZNF789 PE=1 SV=3" "0.044" "False" "1.234" "3" "1" "1" "1" "425" "50.0" "9.10" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "285989" "ENSG00000198556" "ZNF789" "A4D282; A6NH61; hsa:285989; Q5FWF6; Q6ZMZ9" "" "" "0" "0" "1.050" "0.944" "1.303" "1.133" "0.873" "1.143" "0.923" "0.933" "0.826" "22.5" "23.6" "21.2" "29.3" "25.5" "19.6" "25.7" "20.7" "21.0" "18.6" "" "" "" "" "" "" "" "" "" "" "22.5" "20.0" "13.4" "21.3" "20.9" "15.2" "19.8" "17.8" "16.4" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "Medium" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.044" "False" "1.234" "4" "1" "1" "1" "199" "21.9" "5.88" "2.81" "1" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "1.101" "1.118" "0.951" "1.175" "0.936" "0.895" "0.974" "1.375" "1.054" "82.7" "91.0" "92.4" "78.6" "97.2" "77.4" "74.0" "80.5" "113.6" "87.2" "" "" "" "" "" "" "" "" "" "" "82.7" "77.0" "58.4" "57.3" "79.6" "60.1" "57.0" "69.2" "88.7" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6787199481091963945" "False" "Medium" "IsMasterProtein" "P04053" "DNA nucleotidylexotransferase OS=Homo sapiens OX=9606 GN=DNTT PE=1 SV=3" "0.044" "False" "1.233" "3" "1" "1" "1" "509" "58.5" "8.43" "1.60" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01909, Pf10391, Pf14716, Pf14791" "1791" "ENSG00000107447" "DNTT" "hsa:1791; P04053; Q53FH1; Q5W103; Q96E50" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-365130110010146810" "False" "Medium" "IsMasterProtein" "O43345" "Zinc finger protein 208 OS=Homo sapiens OX=9606 GN=ZNF208 PE=1 SV=2" "0.044" "False" "1.231" "1" "1" "1" "1" "1280" "147.4" "9.01" "2.47" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13465, Pf13912" "7757" "ENSG00000160321" "ZNF208" "hsa:7757; O43345" "" "Generic Transcription Pathway" "1" "0" "1.060" "1.029" "0.988" "0.954" "1.033" "0.957" "0.907" "0.782" "0.793" "106.9" "113.4" "110.0" "105.6" "102.0" "110.4" "102.3" "97.0" "83.6" "84.7" "" "" "" "" "" "" "" "" "" "" "106.9" "95.9" "69.6" "77.0" "83.6" "85.8" "78.9" "83.4" "65.2" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6039342044264890236" "False" "Medium" "IsMasterProtein" "Q99808" "Equilibrative nucleoside transporter 1 OS=Homo sapiens OX=9606 GN=SLC29A1 PE=1 SV=3" "0.045" "False" "1.228" "2" "1" "1" "1" "456" "50.2" "8.29" "0.00" "1" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01733" "2030" "ENSG00000112759" "SLC29A1" "B3KQV7; B3KQY5; hsa:2030; Q5T9W9; Q99808; Q9UJY2" "Fluoropyrimidine activity" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Azathioprine ADME; Ribavirin ADME" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529217331400882174" "False" "Medium" "IsMasterProtein" "Q8TC05" "Nuclear protein MDM1 OS=Homo sapiens OX=9606 GN=MDM1 PE=1 SV=2" "0.045" "False" "1.226" "1" "1" "1" "1" "714" "80.7" "9.11" "2.56" "1" "developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15501" "56890" "ENSG00000111554" "MDM1" "B4DM65; E7EPQ3; hsa:56890; O43406; Q8TC05; Q8WTV9; Q9NR04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4112349772012703994" "False" "Medium" "IsMasterProtein" "Q9BRP7" "Ferredoxin-fold anticodon-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FDXACB1 PE=1 SV=3" "0.045" "False" "1.226" "1" "1" "1" "1" "624" "70.4" "6.76" "2.76" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf03147, Pf10354" "91893" "ENSG00000255561" "FDXACB1" "A0PJW7; B4DUU2; hsa:91893; Q9BRP7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7933737644312691090" "False" "Medium" "IsMasterProtein" "Q8TBY9" "Cilia- and flagella-associated protein 251 OS=Homo sapiens OX=9606 GN=CFAP251 PE=1 SV=2" "0.045" "False" "1.226" "1" "1" "1" "1" "1149" "129.9" "5.08" "0.00" "1" "other biological processes" "cytoskeleton" "" "Pf00400" "144406" "ENSG00000158023" "CFAP251" "C9J1W2; hsa:144406; Q8IYA3; Q8N898; Q8NDE7; Q8TBY9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625086563387438209" "False" "Medium" "IsMasterProtein" "Q8NAV2" "Uncharacterized protein C8orf58 OS=Homo sapiens OX=9606 GN=C8orf58 PE=1 SV=2" "0.045" "False" "1.223" "2" "1" "1" "1" "365" "39.6" "8.28" "2.41" "1" "" "" "" "Pf15552" "541565" "ENSG00000241852" "C8orf58" "B4DI44; hsa:541565; Q8NAV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2524487954234531318" "False" "Medium" "IsMasterProtein" "Q9Y6N7" "Roundabout homolog 1 OS=Homo sapiens OX=9606 GN=ROBO1 PE=1 SV=1" "0.045" "False" "1.222" "1" "1" "1" "1" "1651" "180.8" "6.04" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf07679, Pf13927" "6091" "ENSG00000169855" "ROBO1" "B2RXI1; D3DU36; E9PD49; hsa:6091; Q1RMC7; Q7Z300; Q9BUS7; Q9Y6N7" "Development of ureteric collection system; Cell lineage map for neuronal differentiation" "Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity" "11" "0" "0.929" "0.852" "0.988" "1.036" "0.921" "0.973" "0.926" "0.908" "1.112" "55.8" "51.8" "47.5" "55.1" "57.8" "51.4" "54.3" "51.7" "50.7" "62.0" "" "" "" "" "" "" "" "" "" "" "55.8" "43.8" "30.0" "40.2" "47.4" "39.9" "41.8" "44.4" "39.5" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5162723049460562380" "False" "Medium" "IsMasterProtein" "Q9BPU6" "Dihydropyrimidinase-related protein 5 OS=Homo sapiens OX=9606 GN=DPYSL5 PE=1 SV=1" "0.045" "False" "1.221" "1" "1" "1" "1" "564" "61.4" "7.20" "2.86" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01979" "56896" "ENSG00000157851" "DPYSL5" "hsa:56896; Q8TCL6; Q9BPU6; Q9NQC4; Q9NRY9" "" "CRMPs in Sema3A signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "Medium" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.045" "False" "1.218" "8" "1" "1" "1" "90" "10.3" "6.29" "3.17" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "0.982" "1.040" "1.204" "0.981" "1.274" "1.378" "1.029" "0.816" "0.879" "47.4" "46.6" "49.3" "57.1" "46.5" "60.4" "65.3" "48.8" "38.7" "41.7" "" "" "" "" "" "" "" "" "" "" "47.4" "39.4" "31.2" "41.6" "38.1" "46.9" "50.3" "41.9" "30.2" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2689761144797840992" "False" "Medium" "IsMasterProtein" "Q5T8A7" "Protein phosphatase 1 regulatory subunit 26 OS=Homo sapiens OX=9606 GN=PPP1R26 PE=1 SV=1" "0.046" "False" "1.217" "0" "1" "1" "1" "1209" "127.3" "8.59" "2.71" "1" "" "nucleus" "enzyme regulator activity" "Pf15740" "9858" "ENSG00000196422" "PPP1R26" "hsa:9858; Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3" "" "" "0" "0" "0.800" "0.979" "0.902" "0.935" "0.989" "0.909" "0.991" "1.000" "1.136" "94.8" "75.9" "92.8" "85.6" "88.7" "93.8" "86.2" "94.0" "94.9" "107.7" "" "" "" "" "" "" "" "" "" "" "94.8" "64.2" "58.7" "62.4" "72.7" "72.8" "66.4" "80.8" "74.1" "96.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2965457832063428151" "False" "Medium" "IsMasterProtein" "A8MW92" "PHD finger protein 20-like protein 1 OS=Homo sapiens OX=9606 GN=PHF20L1 PE=1 SV=2" "0.046" "False" "1.216" "1" "1" "1" "1" "1017" "114.9" "6.83" "2.37" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf16660, Pf18104, Pf20826" "51105" "ENSG00000129292" "PHF20L1" "A8MW92; A8MZC9; hsa:51105; Q86U89; Q86W43; Q96BT0; Q9H702; Q9HBK3; Q9NYR3; Q9Y381" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1651387541730598869" "False" "Medium" "IsMasterProtein" "Q5VVM6" "Coiled-coil domain-containing protein 30 OS=Homo sapiens OX=9606 GN=CCDC30 PE=1 SV=1" "0.046" "False" "1.215" "1" "1" "1" "1" "783" "91.3" "5.77" "2.23" "1" "" "" "" "Pf15742" "728621" "ENSG00000186409" "CCDC30" "hsa:728621; Q14F06; Q5VVM5; Q5VVM6" "" "" "0" "0" "1.426" "1.057" "1.441" "1.255" "1.526" "1.228" "1.549" "1.458" "1.751" "18.8" "26.8" "19.9" "27.1" "23.6" "28.7" "23.1" "29.1" "27.4" "32.9" "" "" "" "" "" "" "" "" "" "" "18.8" "22.7" "12.6" "19.7" "19.3" "22.3" "17.8" "25.0" "21.4" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6558795401348188313" "False" "Medium" "IsMasterProtein" "Q14CM0" "FERM and PDZ domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FRMPD4 PE=1 SV=1" "0.046" "False" "1.215" "1" "1" "1" "1" "1322" "144.3" "5.25" "0.00" "1" "other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00373, Pf00595, Pf21477" "9758" "ENSG00000169933" "FRMPD4" "A8K0X9; hsa:9758; O15032; Q14CM0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2219943473093868916" "False" "Medium" "IsMasterProtein" "P41247" "Patatin-like phospholipase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PNPLA4 PE=1 SV=3" "0.046" "False" "1.214" "4" "1" "1" "1" "253" "28.0" "9.11" "1.73" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01734" "8228" "ENSG00000006757" "PNPLA4" "A8K1H3; B4E362; hsa:8228; P41247; Q8WW83" "" "Triglyceride catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8728536622393012499" "False" "Medium" "IsMasterProtein" "Q8TE82" "SH3 domain and tetratricopeptide repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=SH3TC1 PE=1 SV=3" "0.046" "False" "1.214" "1" "1" "1" "1" "1336" "146.9" "6.25" "2.21" "1" "" "" "" "Pf00018" "54436" "ENSG00000125089" "SH3TC1" "hsa:54436; Q4W5G5; Q8TE82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-210569023749279335" "False" "Medium" "IsMasterProtein" "Q01484" "Ankyrin-2 OS=Homo sapiens OX=9606 GN=ANK2 PE=1 SV=4" "0.046" "False" "1.213" "0" "1" "1" "1" "3957" "433.4" "5.14" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00023, Pf00531, Pf00791, Pf17809" "287" "ENSG00000145362" "ANK2" "hsa:287; Q01484; Q01485; Q08AC7; Q08AC8; Q7Z3L5" "" "Interaction between L1 and Ankyrins; COPI-mediated anterograde transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7838023985597056986" "False" "Medium" "IsMasterProtein" "Q9NP08" "Homeobox protein HMX1 OS=Homo sapiens OX=9606 GN=HMX1 PE=1 SV=2" "0.046" "False" "1.213" "2" "1" "1" "1" "348" "36.1" "6.65" "1.72" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3166" "ENSG00000215612; ENSG00000288204" "HMX1" "hsa:3166; Q9NP08" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4710494010830770987" "False" "Medium" "IsMasterProtein" "Q8NFX7" "Syntaxin-binding protein 6 OS=Homo sapiens OX=9606 GN=STXBP6 PE=1 SV=2" "0.046" "False" "1.213" "4" "1" "1" "1" "210" "23.5" "9.04" "2.91" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cell component" "" "Pf00957, Pf15277" "29091" "ENSG00000168952" "STXBP6" "D3DS78; hsa:29091; Q8N3H1; Q8N8D5; Q8NFX7; Q96GF3; Q9P008" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.046" "False" "1.212" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.14" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.229" "1.141" "1.333" "1.299" "0.977" "1.203" "1.074" "0.980" "0.804" "82.0" "100.7" "93.5" "109.3" "106.5" "80.1" "98.6" "88.1" "80.3" "65.9" "" "" "" "" "" "" "" "" "" "" "82.0" "85.2" "59.1" "79.7" "87.3" "62.2" "76.0" "75.7" "62.7" "59.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "103112105648951971" "False" "Medium" "IsMasterProtein" "Q8NB16" "Mixed lineage kinase domain-like protein OS=Homo sapiens OX=9606 GN=MLKL PE=1 SV=1" "0.047" "False" "1.210" "1" "1" "1" "1" "471" "54.4" "8.82" "2.44" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07714" "197259" "ENSG00000168404" "MLKL" "A6NCE4; hsa:197259; Q8N6V0; Q8NB16" "DNA damage response (only ATM dependent)" "Regulation of necroptotic cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis" "5" "0" "1.269" "1.010" "1.378" "1.019" "1.003" "1.372" "1.009" "1.101" "1.082" "38.9" "49.4" "39.3" "53.6" "39.6" "39.0" "53.4" "39.2" "42.8" "42.1" "" "" "" "" "" "" "" "" "" "" "38.9" "41.8" "24.8" "39.1" "32.5" "30.3" "41.1" "33.7" "33.4" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8810939646490420813" "False" "Medium" "IsMasterProtein" "P0C646" "Olfactory receptor 52Z1P OS=Homo sapiens OX=9606 GN=OR52Z1P PE=3 SV=2" "0.047" "False" "1.208" "3" "1" "1" "1" "298" "33.4" "8.65" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "" "" "OR52Z1P" "A0A087X1Z4; P0C646" "" "Expression and translocation of olfactory receptors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5567026577194719019" "False" "Medium" "IsMasterProtein" "Q9Y2Z9" "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Homo sapiens OX=9606 GN=COQ6 PE=1 SV=2" "0.047" "False" "1.206" "2" "1" "1" "1" "468" "50.8" "7.30" "1.92" "1" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf01494" "51004" "ENSG00000119723" "COQ6" "B7Z3K8; hsa:51004; Q53GG6; Q86U30; Q96CA1; Q96CK2; Q9Y2Z9" "Nephrotic syndrome" "Ubiquinol biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5785991462990838568" "False" "Medium" "IsMasterProtein" "Q96MR9" "Zinc finger protein 560 OS=Homo sapiens OX=9606 GN=ZNF560 PE=1 SV=2" "0.047" "False" "1.206" "1" "1" "1" "1" "790" "91.1" "8.69" "2.22" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "147741" "ENSG00000198028" "ZNF560" "hsa:147741; Q495S9; Q495T1; Q96MR9" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "Medium" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.047" "False" "1.205" "1" "1" "1" "1" "738" "80.5" "6.92" "2.13" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "0.804" "0.941" "1.108" "1.154" "1.069" "1.116" "1.073" "1.055" "0.972" "51.4" "41.3" "48.3" "56.9" "59.3" "54.9" "57.3" "55.1" "54.2" "49.9" "" "" "" "" "" "" "" "" "" "" "51.4" "35.0" "30.6" "41.5" "48.6" "42.7" "44.2" "47.4" "42.3" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3619599461952727215" "False" "Medium" "IsMasterProtein" "O00300" "Tumor necrosis factor receptor superfamily member 11B OS=Homo sapiens OX=9606 GN=TNFRSF11B PE=1 SV=3" "0.047" "False" "1.205" "2" "1" "1" "1" "401" "46.0" "8.29" "2.94" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00020, Pf00531" "4982" "ENSG00000164761" "TNFRSF11B" "B2R9A8; hsa:4982; O00300; O60236; Q53FX6; Q9UHP4" "Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Clock-controlled autophagy in bone metabolism; Monoamine transport" "TNFs bind their physiological receptors" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200993166108458048" "False" "Medium" "IsMasterProtein" "P29728" "2'-5'-oligoadenylate synthase 2 OS=Homo sapiens OX=9606 GN=OAS2 PE=1 SV=3" "0.047" "False" "1.202" "2" "1" "1" "1" "719" "82.4" "8.25" "2.31" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf10421" "4939" "ENSG00000111335" "OAS2" "A8K9T1; hsa:4939; P29728; Q6PJ33; Q86XX8" "Non-genomic actions of 1,25 dihydroxyvitamin D3; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction" "RSV-host interactions; OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling" "8" "0" "1.106" "0.832" "1.116" "1.023" "1.007" "1.032" "0.995" "0.993" "0.950" "58.5" "64.6" "48.7" "65.2" "59.8" "58.9" "60.3" "58.2" "58.1" "55.5" "" "" "" "" "" "" "" "" "" "" "58.5" "54.7" "30.8" "47.6" "49.0" "45.7" "46.5" "50.0" "45.3" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-850089972800723912" "False" "Medium" "IsMasterProtein" "Q8N4T0" "Carboxypeptidase A6 OS=Homo sapiens OX=9606 GN=CPA6 PE=1 SV=2" "0.048" "False" "1.196" "3" "1" "1" "1" "437" "51.0" "9.52" "2.18" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf00246, Pf02244" "57094" "ENSG00000165078" "CPA6" "hsa:57094; Q8N4T0; Q8NEX8; Q8TDE8; Q9NRI9" "" "" "0" "0" "1.156" "1.563" "1.203" "1.081" "1.270" "1.090" "0.944" "1.376" "1.078" "21.6" "25.0" "33.8" "26.0" "23.3" "27.4" "23.5" "20.4" "29.7" "23.3" "" "" "" "" "" "" "" "" "" "" "21.6" "21.1" "21.3" "18.9" "19.1" "21.3" "18.1" "17.5" "23.2" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2468179521518421534" "False" "Medium" "IsMasterProtein" "Q14117" "Dihydropyrimidinase OS=Homo sapiens OX=9606 GN=DPYS PE=1 SV=1" "0.049" "False" "1.191" "2" "1" "1" "1" "519" "56.6" "7.27" "0.00" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "1807" "ENSG00000147647" "DPYS" "hsa:1807; Q14117" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine catabolism" "3" "0" "1.004" "1.064" "1.143" "1.072" "1.156" "0.939" "1.233" "1.464" "1.284" "43.8" "44.0" "46.6" "50.1" "46.9" "50.6" "41.1" "54.0" "64.1" "56.2" "" "" "" "" "" "" "" "" "" "" "43.8" "37.2" "29.5" "36.5" "38.5" "39.3" "31.7" "46.4" "50.0" "50.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3648988752962304061" "False" "Medium" "IsMasterProtein" "Q96DY2" "Dynein regulatory complex protein 10 OS=Homo sapiens OX=9606 GN=IQCD PE=1 SV=2" "0.049" "False" "1.189" "2" "1" "1" "1" "449" "52.3" "9.25" "2.31" "1" "" "cytoskeleton;other cell component" "" "Pf00612" "115811" "ENSG00000166578" "IQCD" "hsa:115811; Q6ZSU0; Q96DY2" "" "" "0" "0" "0.938" "1.184" "0.994" "0.976" "1.306" "0.991" "1.040" "1.143" "1.089" "106.6" "100.0" "126.2" "106.0" "104.1" "139.2" "105.6" "110.8" "121.9" "116.1" "" "" "" "" "" "" "" "" "" "" "106.6" "84.6" "79.8" "77.3" "85.3" "108.1" "81.4" "95.3" "95.1" "104.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1892003299666365822" "False" "Medium" "IsMasterProtein" "P60484" "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1" "0.049" "False" "1.188" "2" "1" "1" "1" "403" "47.1" "6.37" "1.70" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102, Pf10409" "5728" "ENSG00000171862; ENSG00000284792" "PTEN" "B2R904; F2YHV0; O00633; O02679; P60484; Q6ICT7" "Androgen receptor signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; T cell receptor and co-stimulatory signaling; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Breast cancer pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; DNA damage response (only ATM dependent)" "Synthesis of PIPs at the plasma membrane; Downstream TCR signaling; TP53 Regulates Metabolic Genes; Ub-specific processing proteases; Regulation of PTEN stability and activity; Transcriptional Regulation by MECP2; Synthesis of IP3 and IP4 in the cytosol; Ovarian tumor domain proteases; Negative regulation of the PI3K/AKT network; Regulation of PTEN localization; PTEN Loss of Function in Cancer; Regulation of PTEN mRNA translation" "55" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "Medium" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.049" "False" "1.186" "11" "1" "1" "1" "56" "6.7" "10.13" "2.22" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "748867624032995252" "False" "Medium" "IsMasterProtein" "Q9H6S3" "Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens OX=9606 GN=EPS8L2 PE=1 SV=2" "0.050" "False" "1.185" "2" "1" "1" "1" "715" "80.6" "6.84" "2.29" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00018, Pf08416, Pf18016" "64787" "ENSG00000177106" "EPS8L2" "B3KSX1; B7ZKL3; hsa:64787; Q53GM8; Q8WYW7; Q96K06; Q9H6K9; Q9H6S3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "Medium" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.050" "False" "1.183" "2" "1" "1" "1" "356" "37.7" "4.84" "1.67" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5229695507308408464" "False" "Low" "IsMasterProtein" "Q86SQ4" "Adhesion G-protein coupled receptor G6 OS=Homo sapiens OX=9606 GN=ADGRG6 PE=1 SV=3" "0.050" "False" "1.180" "1" "1" "1" "1" "1221" "136.6" "7.87" "2.19" "1" "developmental processes;signal transduction" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00002, Pf00354, Pf00431, Pf01825" "57211" "ENSG00000112414" "ADGRG6" "hsa:57211; Q5TGN7; Q6DHZ4; Q6F3F5; Q6F3F6; Q6F3F7; Q6F3F8; Q6MZU7; Q86SQ4; Q8IXA4; Q8NC14; Q96JW0" "" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "1" "0" "1.109" "1.005" "1.046" "1.219" "0.996" "1.037" "1.061" "1.107" "1.237" "110.5" "122.6" "111.1" "115.6" "134.7" "110.0" "114.5" "117.3" "122.3" "136.6" "" "" "" "" "" "" "" "" "" "" "110.5" "103.7" "70.2" "84.3" "110.3" "85.4" "88.3" "100.8" "95.5" "122.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4719252290076381373" "False" "Low" "IsMasterProtein" "Cont_A7E3W2" "Galectin-3-binding protein OS=Bos taurus OX=9913 GN=LGALS3BP PE=1 SV=1" "0.050" "True" "1.179" "2" "1" "1" "1" "555" "62.1" "5.60" "0.00" "1" "cell adhesion" "non-structural extracellular;other membranes" "" "Pf00530, Pf07707" "531137" "ENSBTAG00000001368" "LGALS3BP" "A7E3W2; bta:531137; Q2KJF4" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7274845657669851" "False" "Low" "IsMasterProtein" "Q9BQE6" "LBH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LBHD1 PE=1 SV=3" "0.051" "False" "1.174" "4" "1" "1" "1" "289" "31.5" "4.60" "2.19" "1" "other biological processes" "nucleus" "" "Pf15317" "79081" "ENSG00000162194" "LBHD1" "hsa:79081; Q96NA4; Q9BQE6" "" "" "0" "0" "1.032" "1.045" "0.939" "1.069" "1.165" "0.969" "1.035" "1.049" "0.920" "45.2" "46.6" "47.2" "42.4" "48.3" "52.7" "43.8" "46.7" "47.4" "41.6" "" "" "" "" "" "" "" "" "" "" "45.2" "39.4" "29.8" "30.9" "39.6" "40.9" "33.8" "40.2" "37.0" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8396758372392866228" "False" "Low" "IsMasterProtein" "P0CW24" "Paraneoplastic antigen-like protein 6A OS=Homo sapiens OX=9606 GN=PNMA6A PE=1 SV=2" "0.051" "False" "1.173" "2" "1" "1" "1" "399" "43.8" "5.30" "2.64" "1" "" "" "" "Pf14893, Pf20846" "84968" "ENSG00000235961" "PNMA6A" "A8K1G4; D3DWT8; hsa:84968; P0CW24; P0CW26; Q96A40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3248097022098349972" "False" "Low" "IsMasterProtein" "Q7L985" "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 OS=Homo sapiens OX=9606 GN=LINGO2 PE=1 SV=1" "0.051" "False" "1.173" "1" "1" "1" "1" "606" "68.0" "8.13" "2.52" "1" "other biological processes" "non-structural extracellular;extracellular matrix;other membranes" "" "Pf07679, Pf13855" "158038" "ENSG00000174482" "LINGO2" "A8K4K7; B2RPM5; hsa:158038; Q6ZMD0; Q7L985" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2644612551078172980" "False" "Low" "IsMasterProtein" "Q9NYQ3" "2-Hydroxyacid oxidase 2 OS=Homo sapiens OX=9606 GN=HAO2 PE=1 SV=1" "0.051" "False" "1.172" "2" "1" "1" "1" "351" "38.8" "7.64" "2.43" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01070" "51179" "ENSG00000116882" "HAO2" "hsa:51179; Q2TU86; Q5QP00; Q9NYQ3; Q9UJS6" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3625667710298946358" "False" "Low" "IsMasterProtein" "Q9UJ99" "Cadherin-22 OS=Homo sapiens OX=9606 GN=CDH22 PE=1 SV=2" "0.051" "False" "1.172" "1" "1" "1" "1" "828" "89.0" "4.81" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf01049" "64405" "ENSG00000149654" "CDH22" "B9EGK7; hsa:64405; O43205; Q9UJ99" "Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-303142054863253165" "False" "Low" "IsMasterProtein" "Q67FW5" "Queuosine-tRNA galactosyltransferase OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=1 SV=3" "0.051" "False" "1.171" "3" "1" "1" "1" "346" "39.4" "7.78" "0.00" "1" "" "" "other molecular function" "Pf00535" "146712" "ENSG00000175711; ENSG00000277033" "B3GNTL1" "hsa:146712; Q67FW5; Q6GV30; Q8WUT3" "" "O-linked glycosylation of mucins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669899273063133091" "False" "Low" "IsMasterProtein" "Q9H3G5" "Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2" "0.051" "False" "1.171" "2" "1" "1" "1" "476" "54.1" "5.62" "2.85" "1" "protein metabolism" "" "other molecular function" "Pf00450" "54504" "ENSG00000106066" "CPVL" "A4D1A4; hsa:54504; Q6UX20; Q8NBL7; Q96AR7; Q9H3G5; Q9HB41" "" "" "0" "0" "1.103" "1.021" "0.906" "0.969" "1.097" "0.849" "1.011" "1.074" "0.932" "36.1" "39.8" "36.8" "32.7" "34.9" "39.6" "30.6" "36.4" "38.7" "33.6" "" "" "" "" "" "" "" "" "" "" "36.1" "33.6" "23.3" "23.8" "28.6" "30.7" "23.6" "31.3" "30.2" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1526003586708487303" "False" "Low" "IsMasterProtein" "A6NNT2" "Uncharacterized protein C16orf96 OS=Homo sapiens OX=9606 GN=C16orf96 PE=1 SV=3" "0.051" "False" "1.170" "1" "1" "1" "1" "1141" "125.0" "7.03" "1.79" "1" "" "" "" "Pf16043" "342346" "ENSG00000205832" "C16orf96" "A6NNT2; C9JH24" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6807656584660258937" "False" "Low" "IsMasterProtein" "O14514" "Adhesion G protein-coupled receptor B1 OS=Homo sapiens OX=9606 GN=ADGRB1 PE=1 SV=2" "0.051" "False" "1.170" "1" "1" "1" "1" "1584" "173.4" "7.88" "2.43" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00002, Pf00090, Pf01825, Pf02793, Pf16489, Pf19188" "575" "ENSG00000181790" "ADGRB1" "hsa:575; O14514" "p53 transcriptional gene network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8683427190247271421" "False" "Low" "IsMasterProtein" "P15428" "15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Homo sapiens OX=9606 GN=HPGD PE=1 SV=1" "0.051" "False" "1.169" "5" "1" "1" "1" "266" "29.0" "5.86" "2.14" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00106" "3248" "ENSG00000164120" "HPGD" "B4DTA4; B4DU74; B4DV57; D3DP43; E7EV11; hsa:3248; O00749; P15428; Q06F08; Q12998" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence; Prostaglandin synthesis and regulation" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Synthesis of Lipoxins (LX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1742287606696080479" "False" "Low" "IsMasterProtein" "Q8NAA4" "Protein Atg16l2 OS=Homo sapiens OX=9606 GN=ATG16L2 PE=1 SV=2" "0.051" "False" "1.169" "2" "1" "1" "1" "619" "69.0" "9.03" "2.04" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00400, Pf08614" "89849" "ENSG00000168010" "ATG16L2" "A5PL30; B2RPK5; hsa:89849; Q658V4; Q6PID3; Q8NAA4; Q8NBG0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6907811581051477229" "False" "Low" "IsMasterProtein" "Q9P2J9" "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDP2 PE=1 SV=2" "0.052" "False" "1.167" "1" "1" "1" "1" "529" "59.9" "6.07" "2.20" "1" "" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00481" "57546" "ENSG00000172840" "PDP2" "A8K924; hsa:57546; Q9P2J9" "TCA cycle in senescence" "Regulation of pyruvate dehydrogenase (PDH) complex" "2" "0" "0.888" "0.944" "1.339" "1.113" "1.057" "0.934" "1.109" "0.899" "1.053" "42.9" "38.1" "40.5" "57.4" "47.7" "45.3" "40.0" "47.5" "38.5" "45.1" "" "" "" "" "" "" "" "" "" "" "42.9" "32.2" "25.6" "41.9" "39.1" "35.2" "30.9" "40.9" "30.1" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8989956548169889758" "False" "Low" "IsMasterProtein" "Q14C87" "Transmembrane protein 132D OS=Homo sapiens OX=9606 GN=TMEM132D PE=1 SV=1" "0.052" "False" "1.166" "1" "1" "1" "1" "1099" "122.2" "5.73" "0.00" "1" "" "other membranes" "" "Pf15705, Pf15706, Pf16070" "121256" "ENSG00000151952" "TMEM132D" "Q14C87; Q14C96; Q76M59; Q8N1W9; Q8N3Q5; Q8TF57" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666785379209993331" "False" "Low" "IsMasterProtein" "Q92813" "Type II iodothyronine deiodinase OS=Homo sapiens OX=9606 GN=DIO2 PE=1 SV=4" "0.052" "False" "1.166" "4" "1" "1" "1" "273" "30.5" "8.02" "2.28" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00837" "1734" "ENSG00000211448" "DIO2" "B9EGK0; G3V315; hsa:1734; Q6B0A3; Q92813; Q9HCP7; Q9HCP8; Q9P1W4; Q9UDZ1" "Selenium micronutrient network; Selenium metabolism and selenoproteins; Angiopoietin-like protein 8 regulatory pathway; Thyroid hormones production and peripheral downstream signaling effects; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis; Osteoarthritic chondrocyte hypertrophy" "Regulation of thyroid hormone activity" "8" "0" "1.056" "0.972" "1.198" "1.115" "0.925" "1.107" "1.095" "1.002" "1.028" "129.3" "136.5" "125.7" "154.9" "144.1" "119.6" "143.1" "141.6" "129.6" "133.0" "" "" "" "" "" "" "" "" "" "" "129.3" "115.5" "79.5" "113.0" "118.1" "92.9" "110.3" "121.8" "101.1" "119.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505033836213331142" "False" "Low" "IsMasterProtein" "P08910" "Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1" "0.052" "False" "1.165" "3" "1" "1" "1" "425" "48.3" "6.70" "0.00" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00561" "11057" "ENSG00000140526" "ABHD2" "P08910; Q53G48; Q53GU0; Q5FVD9; Q8TC79" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""